Journal of Controlled Release最新文献

{"title":"Self-enhanced ROS-responsive camptothecin prodrug nanoparticles elicit safe and efficient intravesical instillation therapy of bladder cancer","authors":"Kunpeng Liu ,&nbsp;Binbin Jiao ,&nbsp;Guan Zhang ,&nbsp;Zhihua Gan ,&nbsp;Shicong Lai ,&nbsp;Zhenshan Ding ,&nbsp;Qingsong Yu","doi":"10.1016/j.jconrel.2025.113905","DOIUrl":"10.1016/j.jconrel.2025.113905","url":null,"abstract":"<div><div>Bladder cancer remains a significant clinical challenge, necessitating the development of innovative therapeutic strategies. Recent advancements have highlighted the potential of reactive oxygen species (ROS)-responsive drug delivery systems in cancer therapy. In this study, we introduce a novel treatment approach utilizing a ROS-responsive camptothecin (CPT) prodrug encapsulated within a chitosan nanocarrier, named CACPT. Cinnamaldehyde (CA), acting as a ROS generator, forms thioketal bonds with CPT to create a prodrug that responds selectively to the elevated ROS levels within the tumor microenvironment. Upon exposure to high ROS conditions, these thioketal bonds are cleaved, resulting in the simultaneous release of CPT and CA. The liberated CA further enhances ROS production, establishing a positive feedback loop that amplifies the therapeutic effect. The use of amphiphilic chitosan nanocarriers enhances the retention and penetration of the prodrug within bladder tissue, optimizing its therapeutic potential. Our experimental findings demonstrate that this self-enhanced ROS-responsive release promotes increased cellular uptake and significantly enhances the anticancer efficacy of CACPT. These results position CACPT as a promising candidate for intravesical therapy in bladder cancer, potentially overcoming current limitations in treatment options. The innovative combination of ROS-responsive mechanisms and chitosan nanocarriers represents a paradigm shift in bladder cancer therapeutics, offering a multifaceted approach with substantial promise for clinical translation.</div></div>","PeriodicalId":15450,"journal":{"name":"Journal of Controlled Release","volume":"384 ","pages":"Article 113905"},"PeriodicalIF":10.5,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Double-layered core-shell microneedle patch integrated with microparticles for long-acting treatment of osteoporosis","authors":"Bo Xu, Suohui Zhang, Han Liu, Guozhong Yang, Zequan Zhou, Yunhua Gao","doi":"10.1016/j.jconrel.2025.113898","DOIUrl":"https://doi.org/10.1016/j.jconrel.2025.113898","url":null,"abstract":"Osteoporosis is one of the most common diseases affecting the elderly, particularly postmenopausal women. It significantly increases the risk of fractures, reduces quality of life, and adds to the medical burden. Traditional formulations, such as alfacalcidol (ALF) capsules and tablets, have limitations, including difficulties in swallowing and patient resistance to long-term medication use, highlighting the urgent need for a sustained-release ALF formulation. To address this, we developed a double-layered core-shell microneedle patch integrated with ALF-loaded microparticles for the long-acting treatment of osteoporosis. This system aims to reduce administration frequency and improve patient compliance. After application for just 5 min, the patch can be removed, leaving the microneedle tips embedded in the skin. The core-shell structure of the tip consists of a core made of ALF-loaded polylactic-<em>co</em>-glycolic acid (PLGA) microparticles and a shell composed of ethylcellulose (EC). This structure acts as a drug reservoir within the skin, enabling for sustained release of ALF over 14 days. Compared to commercially available ALF tablets which require daily administration, the long-acting ALF double-layered core-shell microneedle patch (ALF-DCSMN) delivers a lower systemic drug dose while demonstrating comparable or better efficacy in increasing bone mass and improving trabecular microstructure. Notably, ALF-DCSMN only requires semimonthly administration. Overall, these promising results suggest that the ALF-DCSMN is a safe, effective, and user-friendly transdermal formulation for the long-acting treatment of osteoporosis.","PeriodicalId":15450,"journal":{"name":"Journal of Controlled Release","volume":"5 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intestinal retentive delivery system for improved disease therapy","authors":"Xin Wu ,&nbsp;Wantao Wu ,&nbsp;Jutaek Nam ,&nbsp;Lei Rong ,&nbsp;Kai Han","doi":"10.1016/j.jconrel.2025.113903","DOIUrl":"10.1016/j.jconrel.2025.113903","url":null,"abstract":"<div><div>Oral drug delivery systems (DDSs) show great advantages in patient compliance due to their convenience and non-invasiveness. Typically, oral DDSs are designed to deliver drugs to the specific gastrointestinal region, and normalize the dysregulated intestinal niche <em>in situ</em>, or facilitate their transport across the biological barriers including mucus and epithelial layers. Prolonging the residence time of oral DDSs in the gastrointestinal tract is indispensable in realizing these goals. However, the hostile gastric environment is not suitable for the retention of susceptible drugs. Intestinal retentive DDSs are promising alternatives for the oral delivery of these drugs. Moreover, intestinal retentive DDSs can provide opportunities for the regulation of mucosal immunity and gut microbiota. In this review, we briefly describe the general information of intestinal transit time and its influencing factors. We next summarize the recent advances of engineering strategies in prolonging the intestinal retention of oral DDSs at nano-, micro-, and macro-scales. While the underlying mechanisms of intestinal retention remain incompletely understood, we discuss the potential theories and evidence. In addition, we discuss how this prolonged retention of oral DDSs modulates the intestinal environment <em>in situ</em> and the systemic immunity.</div></div>","PeriodicalId":15450,"journal":{"name":"Journal of Controlled Release","volume":"384 ","pages":"Article 113903"},"PeriodicalIF":10.5,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel cationic liposome-formulated toll like receptor (TLR) 7/8 agonist enhances the efficacy of a vaccine against fentanyl toxicity","authors":"Fatima A. Hamid ,&nbsp;Nguyet-Minh Nguyen Le ,&nbsp;Daihyun Song ,&nbsp;Hardik Amin ,&nbsp;Linda Hicks ,&nbsp;Sophia Bird ,&nbsp;Karthik Siram ,&nbsp;Brooke Hoppe ,&nbsp;Borries Demeler ,&nbsp;Jay T. Evans ,&nbsp;David J. Burkhart ,&nbsp;Marco Pravetoni","doi":"10.1016/j.jconrel.2025.113901","DOIUrl":"10.1016/j.jconrel.2025.113901","url":null,"abstract":"<div><div>The U.S. opioid epidemic is an extraordinary public health crisis that started in 1990 and significantly accelerated in the last decade. Since 2020, over 100,000 fatal drug overdoses have been reported annually, and 75% of those involved fentanyl and its analogs (F/FA). Accelerating the translation of innovative, effective, and safe treatments is needed to augment existing measures to counteract such a crisis. Active immunization against F/FA and other opioids represents a promising therapeutic and prophylactic strategy for opioid use disorder (OUD) and opioid-induced overdose toxicity. Previously we demonstrated that a vaccine against F/FA comprising a fentanyl-based hapten (F) conjugated to the diphtheria cross-reactive material (CRM), admixed with the novel lipidated toll-like receptor 7/8 (TLR7/8) agonist INI-4001 adsorbed on Alhydrogel® (alum) induced high-affinity fentanyl-specific polyclonal antibodies that protected against fentanyl-induced pharmacological effects in mice, rats, and mini-pigs. Here, INI-4001 was formulated into liposomes with different surface charges, and their impact on F-CRM adsorption, INI-4001 adjuvanticity, and vaccine efficacy were explored. Additionally, as the role of innate immunity in mediating the efficacy of addiction vaccines is largely unknown, we tested these formulations on the activation of innate immunity <em>in vitro</em>. Cationic INI-4001 liposomes surpassed other liposomal and aluminum-based formulations of INI-4001 by enhancing the efficacy of fentanyl vaccines and protecting rats against bradycardia and respiratory depression by blocking the distribution of fentanyl to the brain. Fentanyl vaccines adjuvanted with either cationic INI-4001 liposomes or the aqueous INI-4001 adsorbed to alum induced significant surface expression of co-stimulatory molecules and maturation markers in a murine dendritic cell line (JAWS II), while the former was superior in enhancing the macrophages surface expression of CD40, CD86 and inducible nitric oxide synthase (iNOS), indicative of maturation and activation. These results warrant further investigation of liposome-based formulations of TLR7/8 agonists for improving the efficacy of vaccines targeting F/FA and other drug targets of public health interest.</div></div>","PeriodicalId":15450,"journal":{"name":"Journal of Controlled Release","volume":"384 ","pages":"Article 113901"},"PeriodicalIF":10.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rational design of stimuli responsive nanoparticle systems for the controlled, intracellular delivery of immunotherapeutic and chemotherapeutic agents","authors":"Dennis Huang ,&nbsp;Ishaan Duggal ,&nbsp;Brandon Chau Matthews ,&nbsp;Elaine Lee ,&nbsp;Eric Tong ,&nbsp;Nicholas A. Peppas","doi":"10.1016/j.jconrel.2025.113878","DOIUrl":"10.1016/j.jconrel.2025.113878","url":null,"abstract":"<div><div>Advanced cancer therapeutic strategies are rapidly evolving due to a better fundamental understanding of cancer cell biology and the complex tumor microenvironment. There is a need for better rational design of bioresponsive nanotherapeutics to take cues from the tumor microenvironment and better facilitate the intracellular delivery of multiple cancer therapeutic agents. Biodegradable, cationic nanogels were synthesized via a UV-initiated free radical emulsion polymerization to impart environmentally responsive behavior for the intracellular delivery of immunotherapeutic and chemotherapeutic agents. The 2-(diethylamino) ethyl methacrylate based copolymeric nanogels exhibited pH responsive behavior that was optimized for the pH gradient of the tumor microenvironment and endosomal compartments of cancer cells. Then, the cationic nanogels were assessed for their ability to load and release various chemotherapeutic and immunotherapeutic agents. Finally, the copolymeric nanoparticle system was evaluated in vitro for biocompatibility, cellular internalization, and therapeutic efficacy. This combination treatment strategy will provide an excellent foundation for the rational design and development of the next generation of drug delivery systems.</div></div>","PeriodicalId":15450,"journal":{"name":"Journal of Controlled Release","volume":"384 ","pages":"Article 113878"},"PeriodicalIF":10.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymer-based coating of adeno-associated viral particles as a new strategy to evade immune response for DMD treatment","authors":"María Stampa-López Pinto ,&nbsp;Laia Martí-Melero ,&nbsp;Jennifer Fernandez-Alarcon ,&nbsp;Giovanni Sitia ,&nbsp;Cristina Fornaguera ,&nbsp;Salvador Borrós ,&nbsp;Marta Guerra-Rebollo","doi":"10.1016/j.jconrel.2025.113896","DOIUrl":"10.1016/j.jconrel.2025.113896","url":null,"abstract":"<div><div>Duchenne muscular dystrophy (DMD) is a severe genetic disorder caused by mutations in the dystrophin gene, leading to progressive muscle degeneration. Gene therapy using adeno-associated virus (AAV) vectors holds potential for treating DMD, but challenges such as immune responses and limited efficacy hinder its success. This study proposes a novel approach to improve AAV-based gene therapy by coating AAV vectors with a modified poly(β-amino ester) (pBAE) polymer featuring an NHS-activated acid moiety. The pBAE coating increases the positive surface charge of AAV particles, enhancing their transduction efficiency in muscle cells and reducing interactions with neutralizing antibodies. In vitro and in vivo studies demonstrate that pBAE-coated AAVs exhibit improved transduction efficiency, stability under physiological conditions, and targeted muscle tissue expression. Additionally, the coating protects AAV from neutralizing antibodies and reduces their production, addressing significant limitations in AAV-based gene therapy. This strategy represents a promising advancement in enhancing the efficacy and safety of gene therapy for DMD and potentially other genetic disorders.</div></div>","PeriodicalId":15450,"journal":{"name":"Journal of Controlled Release","volume":"384 ","pages":"Article 113896"},"PeriodicalIF":10.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chitosan and mannose-modified dual-functional mRNA-LNP vaccines for robust systemic and mucosal immune responses","authors":"Jing Yi ,&nbsp;Yicheng Lu ,&nbsp;Nan Liu ,&nbsp;Zengming Wang ,&nbsp;Hui Zhang ,&nbsp;Haonan Xing ,&nbsp;Meng Li ,&nbsp;Lili Jin ,&nbsp;Aiping Zheng","doi":"10.1016/j.jconrel.2025.113891","DOIUrl":"10.1016/j.jconrel.2025.113891","url":null,"abstract":"<div><div>Mucosal vaccination plays a crucial role in activating frontline immune responses, preventing infection and transmission of respiratory pathogens. However, the development of effective mRNA mucosal vaccines faces multiple challenges, including mucosal barriers, suboptimal immune cell targeting, and limited induction of mucosal immunity. In this study, we develop a dual-functional mRNA-LNP-CS+Man vaccine by utilizing DMG-PEG2000-Chitosan and DMG-PEG2000-Mannose, capable of penetrating the pulmonary mucosal barrier and targeting immune cells in the lungs. The results show that, following intratracheal administration, mRNA-LNP-CS+Man exhibits prolonged retention in the lungs for up to 72 h, with widespread distribution across the entire lung and achieving high mRNA transfection throughout the lung, particularly in immune cells. After two immunizations, the vaccine induces strong systemic and mucosal immune responses compared to the unmodified LNP, including efficient production of IgG and IgG2a in serum, IgG and SIgA in bronchoalveolar lavage fluid, and Th1-type cytokines. Significant activation of lung germinal center B (GC B) cells and tissue-resident memory T (TRM) cells were observed, alongside the establishment of effective immune memory. The vaccine demonstrates strong protective efficacy against SARS-CoV-2 D614G pseudovirus in the lungs, offering a novel strategy for mRNA mucosal vaccine development.</div></div>","PeriodicalId":15450,"journal":{"name":"Journal of Controlled Release","volume":"384 ","pages":"Article 113891"},"PeriodicalIF":10.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peptide-based nanoassembly enhances ferroptosis in cancer to overcome paclitaxel resistance","authors":"Congcong Lin ,&nbsp;Jiamin Sun ,&nbsp;Yun Yang ,&nbsp;Xinyao Pan ,&nbsp;Shiyu Wang ,&nbsp;Xiaoyang Li ,&nbsp;Yan Zhang ,&nbsp;Huile Gao ,&nbsp;Chunli Gan","doi":"10.1016/j.jconrel.2025.113895","DOIUrl":"10.1016/j.jconrel.2025.113895","url":null,"abstract":"<div><div>The development of chemotherapy resistance poses a major challenge in cancer therapy. Ferroptosis, a unique type of cell death, offers a promising strategy to combat this resistance. Herein, a peptide-based nanoassembly (PTX@CPG) consisting of paclitaxel (PTX), chlorin e6 (Ce6), and FFVLKPLGLAGK-(PEG8)₃ was constructed to promote ferroptosis through reactive oxygen species (ROS) accumulation and overcome chemoresistance. Specifically, the small-sized PTX@CPG nanoparticles effectively penetrate tumors, where the microenvironment-responsive peptide is selectively cleaved by the high expression of matrix metalloproteinase 2. This process facilitates the targeted release of PTX and its reassembly into nanofibers, improving the tumor retention of Ce6 and enhancing its cellular uptake. The synergistic therapeutic effects of PTX in combination with photodynamic therapy on triple-negative breast cancer cells were validated through both <em>in vitro</em> and <em>in vivo</em> experiments. Impressively, upon laser irradiation, PTX@CPG significantly increased ROS production, thereby amplifying the ferroptosis-inducing effects of PTX. Moreover, ferroptosis triggered by PTX@CPG with laser reduced the levels of P-glycoprotein and glutathione peroxidase 4, contributing to the alleviation of chemoresistance. Overall, PTX@CPG with laser demonstrated effective spatial targeting and drug retention, enhancing ferroptosis through ROS accumulation and showcasing a promising approach for overcoming chemotherapy resistance in cancer therapy.</div></div>","PeriodicalId":15450,"journal":{"name":"Journal of Controlled Release","volume":"384 ","pages":"Article 113895"},"PeriodicalIF":10.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CD44-targeted RIP3 gene delivery strategy for enhanced cancer therapy via necroptosis and immune modulation","authors":"Sang Eun Kim, Soyeon Bak, Jung Hee Park, Ji Eun Lee, Yun Ji Lee, Min Seok Park, Soyeon Ko, Hani Choi, Kyung Hee Jung, Kun Na, Soon-Sun Hong","doi":"10.1016/j.jconrel.2025.113872","DOIUrl":"https://doi.org/10.1016/j.jconrel.2025.113872","url":null,"abstract":"Receptor-interacting protein kinase 3 (RIP3)-mediated necroptosis has attracted interest as a potential target for cancer therapy as it boosts tumor immunogenicity. Here, we synthesized a pH-sensitive polymer (CA) by conjugating aminopropyl imidazole (API) to chondroitin sulfate (CHS) for RIP3 gene delivery. CA can target cancer cells due to the specific binding ability of CHS to CD44 which is overexpressed in cancer cells. In addition, the introduction of API conferred pH sensitivity, facilitating efficient endosomal escape and enhancing gene delivery efficiency. Increased levels of high mobility group box-1, EEA1, and Rab5 and high activation of RIP3/mixed-lineage kinase domain-like pseudokinase signaling were observed in the CA-shielded RIP3 complex (CA-PEI/RIP3)-treated groups. Significant tumor selectivity and ablation efficacy of CA-PEI/RIP3 were confirmed in A549 xenografts and LLC1 orthotopic lung cancer mouse models. Furthermore, CA-PEI/RIP3-induced necroptotic cell death could enhance the immune response by increasing phagocytosis of dendritic cells (DCs), resulting in large numbers of CD4+ and CD8+ T cells and mature DCs infiltrating tumor tissues and lymph nodes. Collectively, CA-PEI/RIP3 showed significant potential in cancer gene therapy due to the enhanced transfection efficiency and the tumor-targeting properties of CA, providing a safe and robust strategy to activate the immune response for cancer immunotherapy.","PeriodicalId":15450,"journal":{"name":"Journal of Controlled Release","volume":"1 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene therapy and nanomedicine for meningioma treatment","authors":"Deepshikha Shahdeo ,&nbsp;Taskeen Iqbal Janjua ,&nbsp;Matthieu Peyre ,&nbsp;Ritu Kulshreshtha ,&nbsp;Amirali Popat PhD (Professor)","doi":"10.1016/j.jconrel.2025.113881","DOIUrl":"10.1016/j.jconrel.2025.113881","url":null,"abstract":"<div><div>Meningioma, a prevalent central nervous system (CNS) tumor, exhibits a broad spectrum of clinical behavior, ranging from benign to aggressive. Although surgical resection remains a viable treatment option for most cases, higher-grade meningiomas often require a multifaceted therapeutic approach. Gene therapies have shown potential for use in clinical intervention for the treatment of several types of cancer. Small nucleic acid molecules such as small interfering RNAs (siRNAs) and microRNAs (miRNAs) can restore aberrant gene expression and selectively silence oncogenic drivers. However, their clinical application could be improved by addressing challenges such as molecular instability, off-target toxicity, and limited bioavailability.</div><div>Despite the rapid progress in nanotechnology that has significantly improved the gene therapy delivery system, its use for meningioma treatment has lagged behind. The lag in research can be attributed to the critical need for a deeper understanding of the molecular landscape of meningioma and its relative resistance to conventional chemotherapy.</div><div>Therefore, our review article focuses on the complex molecular landscape of meningioma and highlights the challenges in its treatment and management. We also discuss the current gene therapy approaches for meningioma, exploring ongoing clinical trials and elucidating the mechanism of emerging therapies. Furthermore, we investigate the potential of nanomedicine in enhancing gene therapy for meningioma, highlighting the need for innovative delivery techniques. This comprehensive analysis not only outlines the status of the therapy in meningioma but also offers valuable insights into the future research direction and their clinical translation.</div></div>","PeriodicalId":15450,"journal":{"name":"Journal of Controlled Release","volume":"384 ","pages":"Article 113881"},"PeriodicalIF":10.5,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}