Recent advances and challenges of injectable hydrogels in drug delivery

IF 10.5 1区医学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Journal of Controlled Release Pub Date : 2025-07-09 DOI:10.1016/j.jconrel.2025.114021

Anna Guo , Qiannan Cao , Huapan Fang , Huayu Tian

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Abstract

Injectable hydrogels, serving as multifunctional biomaterials, exhibit exceptional shear-thinning behavior, tunable mechanical properties, and biocompatibility, attributed to their dynamic porous network structure and biomimetic microenvironment characteristics. It can be used as a drug carrier to achieve precise delivery and controlled release, and regulate cell behavior through biomimetic microenvironment, which has important application prospects in minimally invasive therapy and regenerative medicine. This review systematically describes their classifications, preparation methods, functional modifications, performance optimization and the latest advances including drug and cell delivery, and tissue engineering. Moreover, the current challenges associated with their clinical translation are also discussed, along with strategies to overcome these hurdles. Finally, the future research directions of injectable hydrogels are outlined, with an emphasis on enhancing their clinical applicability and overcoming current technological and clinical barriers to promote the widespread use in precision medicine and personalized therapies. This work will provide valuable insights for the design and application of injectable hydrogel-based biomaterials in biomedicine.

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注射水凝胶在给药中的最新进展和挑战

可注射水凝胶作为多功能生物材料，由于其动态多孔网络结构和仿生微环境特征，具有优异的剪切减薄行为、可调节的机械性能和生物相容性。它可以作为药物载体实现精准给药和控释，通过仿生微环境调节细胞行为，在微创治疗和再生医学中具有重要的应用前景。本文系统地介绍了它们的分类、制备方法、功能修饰、性能优化以及药物和细胞传递、组织工程等方面的最新进展。此外，还讨论了目前与临床翻译相关的挑战，以及克服这些障碍的策略。最后，展望了可注射水凝胶未来的研究方向，重点是提高其临床适用性，克服目前的技术和临床障碍，促进其在精准医疗和个性化治疗中的广泛应用。这项工作将为可注射水凝胶生物材料的设计和应用提供有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Controlled Release 医学-化学综合

CiteScore

18.50

自引率

5.60%

发文量

700

审稿时长

39 days

期刊介绍： The Journal of Controlled Release (JCR) proudly serves as the Official Journal of the Controlled Release Society and the Japan Society of Drug Delivery System. Dedicated to the broad field of delivery science and technology, JCR publishes high-quality research articles covering drug delivery systems and all facets of formulations. This includes the physicochemical and biological properties of drugs, design and characterization of dosage forms, release mechanisms, in vivo testing, and formulation research and development across pharmaceutical, diagnostic, agricultural, environmental, cosmetic, and food industries. Priority is given to manuscripts that contribute to the fundamental understanding of principles or demonstrate the advantages of novel technologies in terms of safety and efficacy over current clinical standards. JCR strives to be a leading platform for advancements in delivery science and technology.