Shuanglong Wang, Mei Yu, Qingfeng Kong, Zhiyuan Leng
{"title":"Contrast-Enhanced Ultrasound Findings in Primary Hepatic Leiomyosarcoma: A Case Misdiagnosed as Liver Abscess.","authors":"Shuanglong Wang, Mei Yu, Qingfeng Kong, Zhiyuan Leng","doi":"10.1002/jcu.70036","DOIUrl":"https://doi.org/10.1002/jcu.70036","url":null,"abstract":"<p><p>Primary hepatic leiomyosarcoma (PHLS) is a rare malignant tumor of mesenchymal origin in the liver, with nonspecific clinical manifestations. High fever as the initial symptom is uncommon, making it easily misdiagnosed as a liver abscess. In this case, the tumor was initially mistaken for a liver abscess. Contrast-enhanced ultrasound (CEUS) corrected the diagnosis and helped avoid inappropriate treatment.</p>","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144816790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dynamic Ultrasound Imaging of Extensor Pollicis Brevis Hypertrophy in Proximal Intersection Syndrome: A Case Report and Literature Review.","authors":"Daoukas Stavros, Galanis Dimitrios, Mathew Benoy, Malliaropoulos Nikos","doi":"10.1002/jcu.70018","DOIUrl":"https://doi.org/10.1002/jcu.70018","url":null,"abstract":"<p><p>This case report presents an atypical presentation of proximal intersection syndrome and provides ultrasound-based evidence of extensor pollicis brevis muscle belly hypertrophy with associated edema in a non-athletic population. While occupationally induced PIS has been previously documented, the patient's symptoms in this case were linked to repetitive lifting tasks involving prolonged extension of the first metacarpophalangeal joint with a wide grip. Dynamic ultrasound assessment revealed radial displacement of the second compartment tendons by the extensor pollicis brevis muscle during the aggravating movement. This finding suggests a novel pathomechanism, potentially driven by mechanical friction and stress between the first and second dorsal compartments, warranting further investigation.</p>","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144816791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jin-Li Wang, Jian Dong, Si-Rui Wang, Chun-Li Cao, Jin Tong, WenXiao Li, Ting-Ting Du, Ting-Ting He, Xiao-Wu Yuan, Jun Li, Hong Zhai
{"title":"Reliability of Ultrasonic Hepatorenal Indices in Assessing Hepatic Steatosis: A Systematic Review and Meta-Analysis.","authors":"Jin-Li Wang, Jian Dong, Si-Rui Wang, Chun-Li Cao, Jin Tong, WenXiao Li, Ting-Ting Du, Ting-Ting He, Xiao-Wu Yuan, Jun Li, Hong Zhai","doi":"10.1002/jcu.70006","DOIUrl":"https://doi.org/10.1002/jcu.70006","url":null,"abstract":"<p><p>The accuracy of the ultrasound hepatorenal index (HRI) in diagnosing hepatic steatosis has varied significantly in different clinical trials. Therefore, we conducted a meta-analysis aimed at exploring the diagnostic accuracy of ultrasound HRI in the quantitative assessment of hepatic steatosis. Thirteen eligible studies published up to May 3, 2025, were obtained through a comprehensive search. We conducted a meta-analysis using a random-effects bivariate model to investigate the diagnostic accuracy of the ultrasound HRI in assessing hepatic steatosis. A total of 1496 cases were included that used liver biopsy or MRI-PDFF as the reference standard to determine the presence of hepatic steatosis. We synthesized the sensitivity, specificity, likelihood ratio, diagnostic advantage ratio, and area under the curve of the included studies to assess the performance of the HRI as a diagnostic tool. The meta-analysis demonstrated that ultrasound HRI had good performance in evaluating hepatic steatosis. However, there were significant differences in diagnostic performance and optimal cut-off values among the included studies, indicating the need for consensus on the optimal cut-off value for diagnosing hepatic steatosis. As an auxiliary means of ultrasonic analysis, ultrasonic HRI has achieved a good diagnostic effect in detecting hepatic steatosis.</p>","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sheng Han, Shuwen Sun, Teng Zhang, Yanyan Zhang, Haibin Shi, Yali Wang, Cuiwei Wang
{"title":"Prediction Model of Ki67 Proliferation Level in Hepatocellular Carcinoma Based on Contrast-Enhanced Ultrasound.","authors":"Sheng Han, Shuwen Sun, Teng Zhang, Yanyan Zhang, Haibin Shi, Yali Wang, Cuiwei Wang","doi":"10.1002/jcu.70027","DOIUrl":"https://doi.org/10.1002/jcu.70027","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the correlation between contrast-enhanced ultrasound (CEUS) features and Ki-67 expression in patients with hepatocellular carcinoma (HCC).</p><p><strong>Methods: </strong>It was a retrospective analysis involving 94 patients with HCC receiving surgeries and diagnosed by postoperative pathology from January 2020 to December 2021. All patients were examined by preoperative CEUS and postoperative Ki-67 immunohistochemistry. Divided by the cut-off of the Ki-67 labeling index, HCC patients were assigned into the low (n = 46) and high Ki-67 expression groups (n = 48). Clinical data and imaging features of CEUS were compared between groups. Finally, a CEUS-based model in predicting abnormal Ki-67 expression in HCC was created.</p><p><strong>Results: </strong>Significant differences showed in the age of onset, alpha fetoprotein (AFP), des-gamma-carboxy prothrombin (DCP), number of lesions, maximum diameter, peripheral hypoechoic halo, boundary, morphology, serrated edge, and internal necrosis between groups (p < 0.05). TIC analysis showed significant differences in the ascending slope (AS), half of the decay time (DT/2), descending slope (DS) and area under the curve (AUC) between groups as well (p < 0.05). Multivariate logistic regression analysis revealed that the number of lesions (OR = 3.845, 95% CI 1.315-11.248, p = 0.014), maximum diameter (OR = 1.064, 95% CI 1.030-1.098, p < 0.001), boundary (OR = 7.017, 95% CI 1.638-30.072, p = 0.009), and morphology (OR = 5.970, 95% CI 1.154-30.879, p = 0.03) were significantly correlated with Ki-67 expression in HCC patients. DS was negatively correlated with Ki-67 expression (OR = 0.000, 95% CI 0.000-0.108, p = 0.013). The AUC of the CEUS-based prediction model was 0.949 (95% CI 0.906-0.992).</p><p><strong>Conclusions: </strong>CEUS images plus TIC analysis provide valuable information to predict preoperative Ki-67 expression in HCC patients, thus favoring clinical management to improve patients' prognosis.</p>","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shuai Gao, Junpu Qu, Rong Wu, Hai Du, Xia Xu, Meilan Zhang, Jing Li
{"title":"A Study on the Value of Ultrasound Imaging Features in Predicting Intraplaque Hemorrhage in Carotid Arteries.","authors":"Shuai Gao, Junpu Qu, Rong Wu, Hai Du, Xia Xu, Meilan Zhang, Jing Li","doi":"10.1002/jcu.70026","DOIUrl":"https://doi.org/10.1002/jcu.70026","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluated the predictive value of ultrasound imaging features for intraplaque hemorrhage (IPH) in carotid atherosclerotic plaques, using high-resolution magnetic resonance vessel wall imaging (HRMR-VWI) as the gold standard.</p><p><strong>Materials and methods: </strong>This prospective study assessed 70 carotid plaques from 56 patients who underwent conventional ultrasound, contrast-enhanced ultrasound (CEUS), and high-resolution magnetic resonance vessel wall imaging (HRMR-VWI). Ultrasound features, including plaque echogenicity (PE), plaque ulceration (PU), juxtaluminal black area (JBA), normalized wall index (NWI), and lumen stenosis rate (LSR), among others, were systematically recorded. Logistic regression and receiver operating characteristic (ROC) curve analyses were conducted to evaluate the diagnostic and predictive value of these features for IPH.</p><p><strong>Results: </strong>PU, JBA, and NWI were identified as independent risk factors for intraplaque hemorrhage (IPH), with odds ratios (ORs) of 7.43 (95% CI: 2.15-25.67, p = 0.002), 4.90 (95% CI: 1.42-16.92, p = 0.012), and 2.55 (95% CI: 1.19-5.45, p = 0.016), respectively. Among individual predictors, NWI showed the highest diagnostic performance, with an area under the curve (AUC) of 0.78 (95% CI: 0.67-0.89). A combined diagnostic model incorporating PU, JBA, and NWI significantly improved performance, achieving an AUC of 0.86 (95% CI: 0.77-0.95), a sensitivity of 81.82%, and a specificity of 78.38%.</p><p><strong>Conclusion: </strong>Ultrasound imaging features, particularly PU, JBA, and NWI, are valuable predictors of IPH in carotid atherosclerotic plaques. Combined analysis of these features significantly enhances diagnostic accuracy. These findings underscore the potential of ultrasound as a cost-effective, noninvasive modality for early IPH detection and stroke risk assessment.</p>","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter to the Editor Regarding \"Fetal Gastroschisis: Review From Diagnosis to Delivery\".","authors":"Oktay Ulusoy","doi":"10.1002/jcu.70037","DOIUrl":"https://doi.org/10.1002/jcu.70037","url":null,"abstract":"","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Heqing Guo, M Hua Yuan, M Bowen Zhao, B Qiqi Hua, B Linhua Wang
{"title":"Ultrasound-Based Z Score and Pulmonary Valve/Aortic Valve Diameter Ratio Improving the Predictive Value of Fetal Aortic Stenosis.","authors":"M Heqing Guo, M Hua Yuan, M Bowen Zhao, B Qiqi Hua, B Linhua Wang","doi":"10.1002/jcu.70028","DOIUrl":"https://doi.org/10.1002/jcu.70028","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate the predictive value of the ultrasound-based Z score for the aortic valve (AV) diameter, pulmonary valve (PV) Z score, and the PV/AV ratio in diagnosing aortic stenosis (AS) in fetuses.</p><p><strong>Methods: </strong>A prospective study of 24 singleton fetuses with suspected AS who underwent two or more fetal echocardiograms was enrolled. Based on the pregnancy outcomes, the prenatal cases were divided into two groups: the AS group and the false-positive group. Electronic spatiotemporal image correlation (eSTIC) technology was used to measure AV and PV of all fetuses, and the AV and PV Z scores, along with the PV/AV ratio, were calculated, compared, and analyzed.</p><p><strong>Results: </strong>In the AS group, significant differences were found between the first and second echocardiograms regarding the AV Z score, PV Z score, and PV/AV ratio. In the false-positive group, only the PV Z score and PV/AV ratio showed significant differences. In the first echocardiogram, the AV Z score and PV/AV ratio significantly differed between the AS and false-positive groups. In the second echocardiogram, only the AV Z score showed differences. An AV Z score < -2.46 showed high sensitivity (89.5%) and specificity (100%) for AS diagnosis. When combined with a PV/AV ratio > 1.64, the predictive value increased.</p><p><strong>Conclusion: </strong>Fetal echocardiography with an AV Z score <-2.46 and a PV/AV ratio > 1.64 provides a higher predictive value for diagnosing AS in fetuses.</p>","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiao-Yong Zhang, Ren-Bo Jin, Guo-Zhen Dang, Wei Ning
{"title":"Timely Diagnosis of Kawasaki Disease Shock Syndrome Based on Positive Transthoracic Echocardiography.","authors":"Xiao-Yong Zhang, Ren-Bo Jin, Guo-Zhen Dang, Wei Ning","doi":"10.1002/jcu.70030","DOIUrl":"https://doi.org/10.1002/jcu.70030","url":null,"abstract":"<p><p>In this article, we describe a Kawasaki disease shock syndrome (KDSS) in a 14-year-old girl, who presented with a fever for 8 days and annular erythema on her back for 2 days. Mycoplasma pneumoniae antibodies were positive. Chest computed tomography showed no abnormalities in the lungs and mediastinum. Treatment with antibiotic drugs proved ineffective. The C-reactive protein(CRP) level was high, and the troponin I and N-terminal brain natriuretic peptide precursor (NT-proBNP) levels were significantly elevated. It was not until transthoracic echocardiography detected bilateral dilation of the coronary artery and right coronary artery diameter z score 3.16 (z score ≥ 2.5) on day 9 of the fever, which was consistent with the changes in Kawasaki disease, that the diagnosis of incomplete Kawasaki disease (IKD) and KDSS was made. Our aim is to accentuate the value of positive transthoracic echocardiography in the diagnosis of IKD and KDSS.</p>","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144794600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jeung Hui Pyo, Soo Jin Cho, Jaehwan Jee, Goeun Park, Joonghyun Ahn, Kyunga Kim, Mira Kang, Aladar D Ronaszeki, Pál Novák Kaposi, Elio Damato, Patrizia Pacini, Carmen Solitoand, Vito Cantisani, Young Hye Byun
{"title":"Ethnic Differences in the Diagnostic Accuracy of a Quantitative Ultrasound-Derived Fat Fraction Estimator for Hepatic Steatosis: External Validation in Asian and Caucasian Cohorts.","authors":"Jeung Hui Pyo, Soo Jin Cho, Jaehwan Jee, Goeun Park, Joonghyun Ahn, Kyunga Kim, Mira Kang, Aladar D Ronaszeki, Pál Novák Kaposi, Elio Damato, Patrizia Pacini, Carmen Solitoand, Vito Cantisani, Young Hye Byun","doi":"10.1002/jcu.70024","DOIUrl":"https://doi.org/10.1002/jcu.70024","url":null,"abstract":"<p><strong>Purpose: </strong>Ultrasound fat fraction estimation (USFF) using quantitative ultrasonography (QUS) is a promising method for assessing liver fat in metabolic dysfunction-associated steatotic liver disease (MASLD). However, its performance across different ethnicities remains unclear. This study aimed to externally validate and compare USFF accuracy in Asian and Caucasian cohorts.</p><p><strong>Methods: </strong>This retrospective analysis used QUS data from three institutions. Participants underwent QUS and magnetic resonance imaging of the proton density fat fraction (MRI-PDFF), the reference standard. A multivariable regression model was developed using two QUS parameters. Linear regression was used to estimate fat fraction, with adjusted R<sup>2</sup> values assessing model fit. The diagnostic performance of USFF for hepatic fat content thresholds (≥ 5%, ≥ 10%, ≥ 20%) was evaluated using the area under the receiver operating characteristic curve (AUC).</p><p><strong>Results: </strong>The development set included 427 South Korean participants, while the validation set comprised 100 from Hungary and 79 from Italy. R<sup>2</sup> values were 0.689, 0.702, and 0.485 for the development, internal validation, and external validation sets, respectively. AUC for detecting hepatic steatosis (MRI-PDFF ≥ 5%) was 0.939 (development) and 0.863 (external validation). Using a cutoff > 0.513, USFF achieved 85.1% sensitivity and 87.4% specificity.</p><p><strong>Conclusion: </strong>USFF is effective but shows variability across populations, highlighting the need for ethnicity-specific models.</p>","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Can We Rely on Anatomical Landmarks in the Fetal Brain to Define a Short Corpus Callosum?","authors":"Romain Corroenne, Houman Mahallati, Anne-Elodie Millischer, David Grevent, Dario Paladini, Laurent J Salomon","doi":"10.1002/jcu.70029","DOIUrl":"https://doi.org/10.1002/jcu.70029","url":null,"abstract":"","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144794599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}