Ugo Maria Pierucci, Irene Paraboschi, Matthieu Peycelon, Chryso P Katsoufis, Alireza Alam, Gabriele Tonni, Mark D Kilby, Gloria Pelizzo, Rodrigo Ruano
{"title":"Comparison of Three Different Staging Systems Capable of Predicting the Severity of Congenital Lower Urinary Tract Obstruction (LUTO) and Its Prognosis.","authors":"Ugo Maria Pierucci, Irene Paraboschi, Matthieu Peycelon, Chryso P Katsoufis, Alireza Alam, Gabriele Tonni, Mark D Kilby, Gloria Pelizzo, Rodrigo Ruano","doi":"10.1002/jcu.70045","DOIUrl":"https://doi.org/10.1002/jcu.70045","url":null,"abstract":"<p><p>Lower urinary tract obstruction (LUTO) is a rare but severe fetal condition associated with significant morbidity and long-term renal risk. Several prenatal staging systems have been proposed to guide management and predict outcomes, yet their comparative prognostic value remains uncertain. This review provides a structured evaluation of three staging systems currently used in clinical practice: those proposed by Ruano, Fontanella, and Nassr. Ruano's system integrates detailed ultrasound findings and biochemical markers, providing explicit stage-specific management recommendations and guidance for specific prenatal therapy. Fontanella's approach depends solely on ultrasound parameters, specifically bladder volume and the gestational timing of oligohydramnios onset, without incorporating biochemical markers or offering clear treatment guidelines. Nassr's score employs both ultrasound and biochemical data within a numerical scoring framework, focusing primarily on identifying severe cases that might benefit from prenatal intervention. Each system has distinct strengths and limitations. Further multicenter validation studies are necessary to determine which staging system most effectively predicts clinical outcomes and optimally guides management for fetuses diagnosed with LUTO.</p>","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gianluca Scotti, Maria Escolino, Claudia Di Mento, Ciro Esposito, Mauro Porcaro, Pasquale Somma, Beatrice Mauriello, Ciro Imbimbo, Felice Crocetto
{"title":"Saving the Testis: A Multimodal Approach to Testicular Epidermoid Cysts in the Adolescent Age Group.","authors":"Gianluca Scotti, Maria Escolino, Claudia Di Mento, Ciro Esposito, Mauro Porcaro, Pasquale Somma, Beatrice Mauriello, Ciro Imbimbo, Felice Crocetto","doi":"10.1002/jcu.70044","DOIUrl":"https://doi.org/10.1002/jcu.70044","url":null,"abstract":"<p><p>Testicular epidermoid cysts (TECs) are rare benign intratesticular lesions that can clinically and radiologically mimic malignant germ cell tumors. We report two cases of adolescent males presenting with painless testicular nodules. Imaging findings-characteristic concentric echogenic rings, absence of vascularity, and normal tumor markers-suggested TECs. In both cases, intraoperative frozen section confirmed the diagnosis, revealing cystic lesions lined by squamous epithelium and filled with lamellar keratin, allowing for testis-sparing surgery. These cases highlight the importance of combining imaging, serum biomarkers, and intraoperative pathology to support conservative management of benign testicular masses.</p>","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preliminary Exploration of Random Flipped Classroom and Simulation Skills Training in Standardized Training for Ultrasound Medical Residents Under the Background of Hierarchical and Progressive Teaching.","authors":"Ceng Wang, Yi Zheng, Cui Xiong, Litao Sun","doi":"10.1002/jcu.70049","DOIUrl":"https://doi.org/10.1002/jcu.70049","url":null,"abstract":"<p><strong>Background: </strong>The random flipped classroom is developed from the standard flipped course. In the random flipped classroom, students engage with class content outside of class, and one student is selected to lead the class activity during class time. This study aimed to train ultrasound residents with the random flipped classroom combined with simulation skills training, which overcame the limitations of the standard flipped classroom, achieving a better clinical performance of ultrasound residents.</p><p><strong>Methods: </strong>Thirty students undergoing standardized training for resident physicians in the department of ultrasound medicine at our hospital were selected and randomly assigned to two groups. Group A entered the random flipped classroom combined with simulation skills training, while Group B received traditional teaching methods. After 2 months of training, both groups underwent theoretical and practical assessments. Subsequently, the teaching methods were switched between the groups for an additional 2 months, followed by another round of assessments. The results from both training stages were then analyzed comparatively.</p><p><strong>Results: </strong>There were no statistically significant differences in baseline characteristics between the two groups of students. After the first stage, the theoretical and skill scores of Group A were higher than those of Group B, which were statistically significant. Following the exchange of training modes between Group A and Group B in the second stage, Group B's theoretical and skill scores showed significant improvements compared to their performance in the first stage. However, there was no significant difference in assessment scores between Group B and Group A in the second stage.</p><p><strong>Conclusions: </strong>Random flipped classroom and simulation skills training could effectively improve clinical performance of both theory and skills among ultrasound residents in standardized training, indicating its potential for broader implementation.</p>","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multimodal Imaging Evaluation of Left Ventricular Sub-Mitral Muscular Diverticulum.","authors":"Na Wang, Yudong Peng","doi":"10.1002/jcu.70043","DOIUrl":"https://doi.org/10.1002/jcu.70043","url":null,"abstract":"<p><p>Left ventricular diverticulum is a very rare congenital cardiac malformation. Due to variations in the size, location, and morphology of the diverticulum, the clinical symptoms of patients differ significantly. Herein, we present a case of a 44-year-old male patient in whom a sub-mitral valve muscular diverticulum of the left ventricle was incidentally discovered during cardiac imaging performed for other conditions. The unique feature is that this diverticulum protruded into the ventricular chamber. This particular type of diverticulum has not been previously reported.</p>","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vinitra Dayalan, R Sri Ramya, Tejo Pratap Oleti, Arati Singh, Geeta Kolar, D Sai Kiran, Mehul A Shah, Sai Kumar Thaduka
{"title":"Antenatal Urinary Tract Dilatation Assessment Using \"UTD Classification System\" and Its Association With Post-Natal Outcomes in a Tertiary Care Center: A Prospective Observational Study.","authors":"Vinitra Dayalan, R Sri Ramya, Tejo Pratap Oleti, Arati Singh, Geeta Kolar, D Sai Kiran, Mehul A Shah, Sai Kumar Thaduka","doi":"10.1002/jcu.70039","DOIUrl":"https://doi.org/10.1002/jcu.70039","url":null,"abstract":"<p><strong>Objectives: </strong>To study the antenatal follow-up of fetal urinary tract dilation (UTD) and its post-natal outcomes using the standard \"UTD Classification System.\"</p><p><strong>Methodology: </strong>In this prospective observational study, fetuses diagnosed with urinary tract dilatation were classified based on the multidisciplinary \"UTD Classification System\" and were followed up throughout the pregnancy and postnatally for 1 year. We excluded fetuses with additional structural abnormalities, genetic disorders, or intrauterine fetal death.</p><p><strong>Results: </strong>During the study period, 46 108 antenatal scans were conducted; according to the eligibility criteria, 593 fetuses were included for analysis, with 81% belonging to the A1 group and 19% to the A2-3 group. The rate of antenatal resolution was significantly higher in the A1 group (64%) compared to the A2-3 group (3%) (p < 0.05). The female gender was protective and had higher spontaneous prenatal resolution among UTD A1 fetuses. However, post-natal persistence at 1 year (49% vs. 0.2%) and the need for surgery (32% vs. 1%) were higher in the A2-3 group. Higher maximum anteroposterior renal pelvic diameter (APRPD) and ureteric abnormalities in the last scan were independent predictors for surgery.</p><p><strong>Conclusion: </strong>Ours is one of the largest prospective studies on UTD classification. Key points noted in this study are that most of the resolving UTDs were from UTD A1, and obstructive uropathies were from the UTD A2-3 group. Higher maximum APRPD and ureteric abnormalities were independent predictors for surgery in the UTD A2-3 group.</p>","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ultrasound Findings of a Brown Tumor in the Metatarsal Bone due to Primary Hyperparathyroidism: A Case Report.","authors":"Jiahao Fu, Chao Chen, Suhong Shen, Zhuo Fu, Fengqin Geng, Pai Xu, Wenjing Guo","doi":"10.1002/jcu.70035","DOIUrl":"https://doi.org/10.1002/jcu.70035","url":null,"abstract":"<p><p>Brown tumor is a benign, nonneoplastic lesion resulting from hyperparathyroidism, typically found in long bones, clavicles, ribs, pelvis, and the mandible. We present a case of brown tumor secondary to primary hyperparathyroidism, with the initial presentation in the right metatarsal bone. We then describe and summarize the characteristic ultrasound features of brown tumors observed in this case. Ultrasound can detect characteristic bone destruction and typical cystic formations in the diagnosis of brown tumors, providing valuable information for the diagnosis of this condition.</p>","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Accuracy of Bowel Ultrasound for Detecting Inflammatory Bowel Disease at a Tertiary Hospital in Central South Africa.","authors":"Amanda Hendricks, Henra Muller","doi":"10.1002/jcu.70041","DOIUrl":"https://doi.org/10.1002/jcu.70041","url":null,"abstract":"<p><strong>Background: </strong>To prevent complications, early diagnosis and treatment of inflammatory bowel disease (IBD) are crucial. The gold standard for diagnosis is colonoscopy with biopsy, which is invasive and costly. Bowel ultrasound (BUS) is a non-invasive and accurate diagnostic imaging tool. Thus, the aim of this study was to evaluate the accuracy of BUS in detecting IBD, compared to the gold standard of colonoscopy with biopsy.</p><p><strong>Objectives: </strong>A BUS imaging protocol for IBD was used to make a preliminary diagnosis of IBD with a BUS scan. The preliminary diagnoses were compared to the confirmatory diagnoses that used histology.</p><p><strong>Method: </strong>A radiologist made a preliminary diagnosis using the instrument BUS parameter measurements. Fisher's exact test (p = 0.05) was performed to determine if an association existed between the preliminary IBD diagnosis and confirmation. The accuracy of BUS diagnosis was calculated for the individual parameters and the preliminary ultrasound diagnosis.</p><p><strong>Results: </strong>Of the participants, 47 (61%) were diagnosed with IBD, and 30 (39%) were negative. The majority had thickened bowel walls and increased bowel wall vascularity. The BUS parameters of bowel wall thickness and vascularity accuracy were above 80%. Bowel wall stratification, haustration, fatty wrapping, peristalsis, mesenteric lymph nodes, and free fluid ranged between 66% and 71%. The overall accuracy of BUS parameters exceeded 80%.</p><p><strong>Conclusion: </strong>The potential of using BUS parameters as a sifting or screening tool should be considered in the workup to expedite the diagnosis of IBD.</p><p><strong>Contribution: </strong>The identification and description of BUS parameters for ultrasound diagnosis of IBD may facilitate the diagnosis and monitoring of IBD.</p>","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elisabet Baldrich, Montse Comas, Alicia Maldonado, Marcos Blasco, Josep-Maria Manresa-Domínguez, Maria Iniguez-Cruz, Antoni Borrell
{"title":"Efficacy of Fetal Ear Length as a Prenatal Marker of Chromosomal Anomalies: A Prospective, Multicenter Cohort Study in a Southern European Population.","authors":"Elisabet Baldrich, Montse Comas, Alicia Maldonado, Marcos Blasco, Josep-Maria Manresa-Domínguez, Maria Iniguez-Cruz, Antoni Borrell","doi":"10.1002/jcu.70040","DOIUrl":"https://doi.org/10.1002/jcu.70040","url":null,"abstract":"<p><strong>Objective: </strong>To develop a nomogram of fetal ear length (FEL) by gestational age in a healthy pregnant Southern European population and assess its potential as a prenatal ultrasound marker of chromosomal anomalies in this demographic.</p><p><strong>Methods: </strong>This prospective, multicenter cohort study included low-risk pregnancies from 11 + 2 to 34 + 6 gestational age. A nomogram was constructed based on gestational age for healthy fetuses with normal perinatal outcomes. Intraobserver and interobserver reliability were evaluated. To assess the efficacy of FEL as a marker of chromosomal anomalies, a multivariate logistic regression analysis was performed; sensitivity and specificity were calculated.</p><p><strong>Results: </strong>A total of 1923 FEL measurements were obtained from 1331 singleton pregnancies. Using data from healthy fetuses, a nomogram was constructed through linear regression analysis. Measurement feasibility was excellent, with intra- and interobserver correlation coefficients of 0.996 (95% confidence interval [CI]: 0.995-0.997) and 0.998 (95% CI: 0.978-0.999), respectively. FEL achieved a sensitivity of 81.8% and a specificity of 49.8% in detecting chromosomal anomalies. Multivariate logistic regression indicated that FEL ≤ 5th percentile significantly increased the likelihood of detecting chromosomal anomalies (odds ratio = 3.11); although the wide 95% CI (1.92-10.7) suggests a cautious interpretation of this finding.</p><p><strong>Conclusions: </strong>While FEL demonstrates potential as a prenatal marker of chromosomal anomalies, its clinical utility remains limited due to moderate sensitivity and specificity. Further studies are warranted to refine its diagnostic value in routine screening practices.</p>","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eyad Bitar, Aimann Surak, Rula Agarushi, Dawn Pepper, Matt Hicks, Abbas Hyderi, Lisa K Hornberger, Luke Eckersley, Kumar Kumaran
{"title":"Assessing the Utility of Targeted Neonatal Echocardiography for Congenital Heart Disease Detection: Retrospective Cohort Analysis.","authors":"Eyad Bitar, Aimann Surak, Rula Agarushi, Dawn Pepper, Matt Hicks, Abbas Hyderi, Lisa K Hornberger, Luke Eckersley, Kumar Kumaran","doi":"10.1002/jcu.70032","DOIUrl":"https://doi.org/10.1002/jcu.70032","url":null,"abstract":"<p><strong>Purpose: </strong>Targeted neonatal echocardiography (TNE) is increasingly utilized by neonatologists to assess hemodynamics, particularly when cardiology-performed echocardiography (CPE) is unavailable. It is crucial that TNE screens and identifies structural abnormalities. This study evaluated the agreement between TNE and CPE in detecting significant congenital heart disease (CHD).</p><p><strong>Methods: </strong>This retrospective, single-center cohort study included infants who underwent TNE between 2015 and 2019 and had at least one complete CPE before discharge. Infants with a known CHD diagnosis prior to TNE were excluded. Atrial septal defects (ASD) < 3 mm, peripheral pulmonary stenosis, and patent ductus arteriosus were excluded. Agreement between TNE and CPE was assessed using correlation coefficients and kappa statistics.</p><p><strong>Results: </strong>A total of 339 infants with 954 TNE scans were included. TNE identified CHD in 41 infants, with all but one (a false positive bicuspid aortic valve) confirmed by CPE. TNE missed CHD in 29 infants (31 lesions), mostly minor, with only one case (pulmonary stenosis) requiring intervention. The overall agreement was 91.15%, with a kappa of 0.68 (p < 0.0001).</p><p><strong>Conclusion: </strong>TNE demonstrated good agreement with CPE in detecting significant CHD in a low-risk neonatal population. Most missed lesions were minor, underscoring the importance of ongoing training and quality assurance.</p>","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lingna She, Man Yang, Heming Wu, Kaiyi Liu, Liyan Chen
{"title":"Prenatal Ultrasound Findings of X-Linked Hypohidrotic Ectodermal Dysplasia: A Case Report.","authors":"Lingna She, Man Yang, Heming Wu, Kaiyi Liu, Liyan Chen","doi":"10.1002/jcu.70033","DOIUrl":"https://doi.org/10.1002/jcu.70033","url":null,"abstract":"<p><p>X-linked hypohidrotic ectodermal dysplasia (HED) is a rare congenital hereditary disorder primarily affecting ectodermal-derived organs, including hair, sweat glands, and teeth. This case report presents a prenatal diagnosis of HED in a fetus without a familial history or parental phenotypic manifestations. The critical prenatal ultrasound finding was an abnormality in the alveolar bone. Genetic testing confirmed the fetus as a hemizygote for a mutation in the ectodysplasin A gene. This comprehensive study delineates the prenatal ultrasound observations, genetic testing outcomes, and post-mortem pathological findings associated with this syndrome. We also highlight essential considerations for early diagnosis through prenatal ultrasound examinations.</p>","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}