Journal of Clinical Periodontology最新文献

{"title":"Correction to “Activation of PGC-1 Alpha-Dependent Mitochondrial Biogenesis Supports Therapeutic Effects of Silibinin Against Type I Diabetic Periodontitis”","authors":"","doi":"10.1111/jcpe.14148","DOIUrl":"10.1111/jcpe.14148","url":null,"abstract":"<p>Xiaoyu, S., P. Yifan, L. Xumin, M. Yixin, C. Yang, S. Lixi, H. Xinhua, C. Liang, C. Shuhong, C. Zelin, C. Pan, S. Zhongchen, W. Daniel, W. Gang, J. Yinhui, and H. Shengbin. 2023. “Activation of PGC-1 Alpha-Dependent Mitochondrial Biogenesis Supports Therapeutic Effects of Silibinin Against Type I Diabetic Periodontitis.” <i>Journal of Clinical Periodontology</i> 50, no. 7: 964–979. https://doi.org/10.1111/jcpe.13811.</p><p>We apologise for this error.</p>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 5","pages":"799"},"PeriodicalIF":5.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14148","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic Azithromycin as an Adjunct to Non-Surgical Subgingival Instrumentation in the Treatment of Stage III/IV, Grade C Periodontitis: 12-Month Clinical, Microbiological and Cytokine Results of a Randomised Controlled Trial","authors":"Srinivas Sulugodu Ramachandra,&nbsp;Valerie Woodford,&nbsp;Pingping Han,&nbsp;Ryan S. B. Lee,&nbsp;Sašo Ivanovski","doi":"10.1111/jcpe.14150","DOIUrl":"10.1111/jcpe.14150","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate the clinical, microbial and cytokine changes following the use of oral azithromycin as an adjunct to non-surgical subgingival instrumentation (NSI) in stage III/IV, grade C periodontitis through a triple-blind, parallel-armed, randomised controlled trial.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>A total of 52 patients with stage III/IV grade C periodontitis were randomly allocated to two groups receiving NSI with or without adjunctive azithromycin. The primary outcome was changes in the periodontal inflamed surface area (PISA) values over 12 months, and the secondary outcomes included changes in pocket depth (PD), clinical attachment loss (CAL), percentage of sites with PD of 1–3, 4–5, ≥ 5 and ≥ 6 mm, subgingival periodontal pathogens, cytokine levels and patient-reported outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At 3 and 12 months, there were no statistically significant differences in the reduction in PISA or other clinical parameters between the groups. At 3 months, the levels of several periodontal pathogens were significantly reduced in the azithromycin group. No significant differences were observed in the levels of periodontal pathogens at 12 months except for <i>\u0000 Prevotella intermedia.</i> No significant differences were observed for the studied cytokines at 3 and 12 months.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The results of this study do not support the use of systemic azithromycin in stage III/IV, grade C periodontitis.</p>\u0000 \u0000 <p>\u0000 <b>Trial Registration:</b> The trial was registered prospectively in the Australia New Zealand Clinical Trial Registry, ACTRN12619000560190. https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=374699\u0000 </p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 5","pages":"666-680"},"PeriodicalIF":5.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14150","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging Applications of Digital Technologies for Periodontal Screening, Diagnosis and Prognosis in the Dental Setting","authors":"Roberto Farina,&nbsp;Anna Simonelli,&nbsp;Leonardo Trombelli,&nbsp;Johanna B. Ettmayer,&nbsp;Jan L. Schmid,&nbsp;Christoph A. Ramseier","doi":"10.1111/jcpe.14156","DOIUrl":"10.1111/jcpe.14156","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To comprehensively review digital technologies (including artificial intelligence, AI) for periodontal screening, diagnosis and prognosis in the dental setting, focusing on accuracy metrics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Two separate literature searches were conducted for periodontal screening and diagnosis (part I, scoping review) and prognosis (part II, systematic approach). PubMed, Scopus and Embase databases were searched.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In part I, 40 studies evaluated AI and advanced imaging on different substrata. The combination of AI with 2D radiographs was the most frequently investigated and demonstrated a high level of periodontitis detection and stage definition. In part II, eight studies, identified as having a high risk of bias, tested supervised machine learning models using 6–74 predictors. The models demonstrated variable predictive accuracy, often outperforming traditional risk assessment tools and classical statistical models in the few studies evaluating such comparisons.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>AI and advanced imaging techniques are promising for periodontal screening, diagnosis and prognosis in the dental setting, although the evidence remains inconsistent and inconclusive. In addition, AI-driven analysis of 2D radiographs (for diagnosis and staging of periodontitis), neural networks and the aggregation of multiple algorithms (for predicting tooth-related outcomes) appear to be the most promising approaches entering clinical application.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 S29","pages":"211-245"},"PeriodicalIF":5.8,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methods for Clinical Assessment in Periodontal Diagnostics: A Systematic Review","authors":"I. H. Stødle,&nbsp;J.-C. Imber,&nbsp;S. V. Shanbhag,&nbsp;G. E. Salvi,&nbsp;A. Verket,&nbsp;A. Stähli","doi":"10.1111/jcpe.14145","DOIUrl":"10.1111/jcpe.14145","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This systematic review aimed to answer the following PECOS questions: In human subjects with untreated periodontitis (Q1) or enrolled in supportive periodontal care (SPC) (Q2) (P), are there clinical assessment methods (E) other than the contemporary manual probe (C) that increase diagnostic accuracy or reliability when examining/screening for periodontitis (Q1) or when monitoring disease stability or progression (Q2) (O) as demonstrated in clinical studies (S)?</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>A single search strategy was devised to identify relevant studies addressing Q1 and Q2 from four electronic databases. The main clinical parameters considered were probing depth (PD) and clinical attachment level (CAL). Risk of bias (RoB) was assessed using a modified Newcastle-Ottawa scale.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 5417 identified titles, 26 studies were finally included. The evidence revealed that manual probes generally yielded higher PD values, while pressure-sensitive/electronic probes demonstrated a trend for higher inter- and intra-examiner reproducibility. No clear trend for the superiority of one probe over the other could be identified for Q1 or Q2.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The outcomes of the present systematic review indicated no clear benefit from the use of pressure-sensitive/electronic probes over contemporary manual probes. Manual probes remain the clinical standard for the diagnosis and monitoring of periodontitis patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 S29","pages":"58-73"},"PeriodicalIF":5.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol Consumption, Risk of Periodontitis and Change of Periodontal Parameters in a Population-Based Cohort Study","authors":"Sebastian-Edgar Baumeister,&nbsp;Janka Schössow,&nbsp;Gustavo G. Nascimento,&nbsp;Henry Völzke,&nbsp;Thomas Kocher,&nbsp;Birte Holtfreter","doi":"10.1111/jcpe.14154","DOIUrl":"10.1111/jcpe.14154","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To investigate the association of alcohol consumption with periodontitis risk and change in periodontal parameters over time.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Using data from 1285 participants of two population cohort studies embedded in the Study of Health in Pomerania, we associated baseline average alcohol consumption with incident periodontitis measured after a median follow-up time of 5.0 years, adjusting for confounding and selection bias using multivariable regression and multiple imputation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Baseline alcohol intake was prospectively associated with a higher risk of periodontitis (relative risk of 1.08 (95% confidence interval: 1.06, 1.10) and 1.23 (1.17, 1.28) for 30 and 60 g per day (g/day) versus 10 g/day), deeper periodontal pockets, higher clinical attachment levels (CAL) and a higher proportion of sites with probing depths and CAL ≥ 3 mm and ≥ 4 mm.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our results support the hypothesis that higher alcohol intake modestly increases the risk of periodontitis. Sensitivity analysis suggested that unmeasured confounding and selection bias could explain the observed association.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 7","pages":"1024-1031"},"PeriodicalIF":5.8,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14154","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Osseous Morphology Following Non-Surgical Periodontal Therapy: A Possible Paradigm Shift for the Treatment of Intrabony Defects?","authors":"Luigi Nibali,&nbsp;Pierpaolo Cortellini","doi":"10.1111/jcpe.14141","DOIUrl":"10.1111/jcpe.14141","url":null,"abstract":"<p>Sub-gingival non-surgical periodontal therapy (NSPT) constitutes step 2 of periodontal therapy, aiming to disrupt the subgingival microbial biofilm and resolve or reduce inflammation of the supracrestal periodontal tissues. A plethora of original studies and reviews have been published over several decades, highlighting its fundamental importance in periodontal therapy and in tooth survival. Evidence shows that step 2 therapy leads to probing pocket depth reduction, associated with increase in gingival recession, clinical attachment level gain and improvements in patient-reported outcome measures, as well as to a reduction in local and, to some extent, systemic inflammatory markers. In cases of intrabony defects, NSPT has traditionally been considered a necessary step to improve periodontal tissue tone and reduce inflammation, thus paving the way for the surgical step, such as periodontal regeneration. This commentary presents compelling arguments for a paradigm shift showing that step 2 therapy also leads to changes in osseous morphology, particularly evident in, but probably not limited to, intrabony defects. This introduces a new dawn, where attempts should be made to understand the mechanisms behind this phenomenon and to maximise the potential of non-surgical therapy to achieve disease resolution and defect/pocket improvements while reducing patient morbidity even in complex periodontal defects.</p>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 6","pages":"836-842"},"PeriodicalIF":5.8,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14141","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiological, Inflammatory and Clinical Outcome of Citric Acid Passivated Definitive Abutments: Interim 12-Month Results From a Randomised Controlled Clinical Trial","authors":"Javi Vilarrasa,&nbsp;Carlos Pereira Couto,&nbsp;Gerard Àlvarez,&nbsp;Neus Carrió,&nbsp;Javier Gil,&nbsp;Vanessa Blanc,&nbsp;José Nart","doi":"10.1111/jcpe.14146","DOIUrl":"10.1111/jcpe.14146","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To assess the efficacy of citric acid passivation on implant abutments by evaluating their impact on bacterial load, microbiome composition, inflammatory response, and clinical and radiographic outcomes compared with control abutments over a 12-month follow-up period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Implants were placed subcrestally in the posterior sextants and randomly assigned to receive a 2-mm high definitive abutment, either with citric acid passivation (CA group) or without (CTR group). Final restorations were delivered after 12 weeks. Samples of the peri-implant crevicular fluid were collected at 3, 6 and 12 months for microbiological and inflammatory analysis. Clinical and radiographic measurements were also performed at these intervals. The primary outcome was total bacterial quantification (log CFU/mL).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Data from 17 patients in the CA group and 16 in the CTR group were analysed. At 12 months, there were no significant differences in total bacterial load between groups (<i>p</i> = 0.689). The biofilm was predominantly composed of commensal bacterial genera in both groups throughout the study period. Although no significant differences were observed in the microbiome alpha- and beta-diversity (<i>p</i> &gt; 0.05), the microbiome within study time points showed an increased beta-diversity in the CA group at 12 months (<i>p</i> = 0.019). CA abutments also showed a higher differential abundance of peri-implant pathogenic bacterial genera at 12 months. At the 6-month mark, the CA group exhibited a trend toward lower IL-1β levels compared with the CTR group (<i>p</i> = 0.072). No significant differences were noted in other clinical or radiographic parameters.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Citric acid passivation of definitive abutments does not enhance the microbiological or inflammatory profiles in the short term. Further studies are needed to explore the potential benefits of citric acid passivation on implant abutments.</p>\u0000 \u0000 <p>\u0000 <b>Trial Registration:</b> Initially registered on clinicatrials.gov (NCT05592327)</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 6","pages":"813-825"},"PeriodicalIF":5.8,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-Centre External Validation of a Nomogram for 10-Year Periodontal Tooth Loss Prediction","authors":"Matteo Serroni,&nbsp;Andrea Ravidà,&nbsp;Pasquale Santamaria,&nbsp;Debora R. Dias,&nbsp;Guo-Liang Cheng,&nbsp;Samar Shaikh,&nbsp;Nima David Natanzi,&nbsp;Muhammad H. A. Saleh,&nbsp;Luigi Nibali,&nbsp;Giuseppe Troiano","doi":"10.1111/jcpe.14143","DOIUrl":"10.1111/jcpe.14143","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To externally validate the potential applicability of the 2018 classification of periodontal diseases as a risk assessment tool, through the use of a nomogram built on a multivariate predictor model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Data from 459 patients with periodontitis, across four cohorts (three in the United States, and one in the United Kingdom), were retrospectively analysed. After staging and grading periodontitis before active periodontal therapy (APT), patients were categorised by the model as having ‘low tooth loss’ (≤ 1 teeth lost due periodontal reasons [TLP]) or ‘high tooth loss’ (≥ 2 TLP) at a 10-year follow-up. Model discrimination was evaluated using the area under the receiver operating characteristic (AUC-ROC) curve. Calibration was assessed through calibration plots, calibration-in-the-large (CITL), calibration slope and the expected:observed (E:O) ratio. Recalibration methods, including Temperature Scaling, Isotonic Regression and Beta Calibration, were also tested.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The original nomogram yielded an aggregate AUC-ROC 0.72 but showed poor calibration. Isotonic recalibration improved the AUC-ROC to 0.77 and enhanced calibration metrics, achieving an <i>E</i>-statistic of 1.00, CITL of 0.00 and a calibration slope of 1.00.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>A nomogram based on the components of the 2018 periodontal disease classification can serve as a prognostic tool with cross-site applicability across clinical settings in industrialised countries, accurately predicting the 10-year risk of tooth loss due to periodontitis from the initial assessment conducted before the start of APT.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 7","pages":"1044-1055"},"PeriodicalIF":5.8,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14143","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intermittent Fasting Regimes Reduce Gingival Inflammation: A Three-Arm Clinical Trial","authors":"C. L. Pappe,&nbsp;J. Maetschker,&nbsp;S. Dujardin,&nbsp;B. Peters,&nbsp;O. Pivovarova-Ramich,&nbsp;F. Kandil,&nbsp;A. Michalsen,&nbsp;C. Breinlinger,&nbsp;N. Steckhan,&nbsp;D. Koppold,&nbsp;H. Dommisch","doi":"10.1111/jcpe.14151","DOIUrl":"10.1111/jcpe.14151","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate the effect of religious Bahá'í dry fasting (BF) or 16:8 time-restricted eating (TRE) compared with a regular diet (CG) on periodontal parameters during a modified experimentally induced gingivitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>All participants were asked to refrain from oral hygiene (3 sextant) for 9 days (T1–T2) and were followed for a total of 19 days (T3) while adhering to fasting or a regular diet and resuming oral hygiene. The primary outcome was bleeding on probing in the test sextant (BOP_s), Rustogi plaque index (RPI), gingival crevicular fluid (GCF), blood pressure (BP), body weight (BW), HbA1c and C-reactive protein (CRP) were measured (T1–T3) and ANCOVA and post hoc comparison were applied.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Sixty-six healthy participants were recruited. Forty-three were randomly assigned to TRE (<i>n</i> = 22) and CG (<i>n</i> = 21), while 23 followed BF, avoiding food and drinks during the day. At T2, BF demonstrated significantly less increase in BOP_s, and GCF increased in CG only. Analysis revealed significant differences in change for BOP_s between BF and CG (−9.48% [−17.18; −1.79]) and BF and TRE (−9.19% [−15.07; −3.32]) as well as for GCF between BF and CG (−0.06 μL [−7.22; −0.66]) and TRE and CG (−0.08 μL [−0.17; −0.00]).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study indicates beneficial effects of different fasting protocols on oral experimental gingivitis and metabolic parameters, but results are limited by randomisation issues and potential bias in the BF group.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 5","pages":"681-694"},"PeriodicalIF":5.8,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14151","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontitis History Shapes the Early Peri-Implant Microbiome Formation: A Metagenomic Analysis","authors":"Miao Wang,&nbsp;Yi Bing Liu,&nbsp;Wai Man Tong,&nbsp;Wai Keung Leung,&nbsp;Long Long He,&nbsp;Xin Xu,&nbsp;Dan Xu,&nbsp;Qin Zhou","doi":"10.1111/jcpe.14147","DOIUrl":"10.1111/jcpe.14147","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aims to investigate the early alterations in microbiome construction and succession around dental implants in both periodontally healthy individuals and patients with a history of periodontitis during the first month after implant–crown placement.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Ninety-five subgingival plaque samples were collected from 10 periodontally compromised patients (PCP) and nine periodontally healthy patients (PHP) at four time points with a 1-week interval and analysed using dynamic metagenomic analysis. The study compared the formation and temporal change in the peri-implant microbiome in the PCP and PHP groups during the first month after the implant crown placement. A two-year follow-up examination was conducted to assess the clinical outcomes of early peri-implant dysbiosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results showed that PCP groups exhibited distinctively dysbiotic features in their peri-implant microbiome upon initial establishment, with an earlier and elevated emergence of periodontopathogens. This dysbiosis in the PCP group was associated with significantly higher modified sulcus bleeding index (mBI) scores compared with the PHP group. <i>Neisseria</i> was identified as a key driver of early peri-implant dysbiosis in patients with a periodontitis history.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study established the first microbial link between periodontitis history and early peri-implant dysbiosis, highlighting the importance of early prevention strategies against peri-implant diseases in patients with a periodontitis history.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 7","pages":"1011-1023"},"PeriodicalIF":5.8,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14147","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}