Journal of Clinical Periodontology最新文献

{"title":"Systemic Lipidomics Identifies Altered Ceramide-Phospholipid Balance Associated With Periodontitis Severity: A Cross-Sectional Study With 12-Year Follow-Up.","authors":"Minja Tuomivaara, Anne-Mari Halme, Muhammed Manzoor, Elina Salasuo, Susanna Paju, Päivi Mäntylä, Kåre Buhlin, Laura Lahdentausta-Suomalainen, Reijo Laaksonen, Juha Sinisalo, Pirkko Pussinen, Aino Salminen","doi":"10.1111/jcpe.70182","DOIUrl":"https://doi.org/10.1111/jcpe.70182","url":null,"abstract":"<p><strong>Aim: </strong>To investigate whether periodontitis stage and grade are associated with circulating active lipid mediators and whether baseline lipid species predict periodontitis progression.</p><p><strong>Materials and methods: </strong>The study included 473 Finnish participants from the Parogene cohort undergoing coronary angiography, with 12-year follow-up data available for 117 individuals. Periodontal status was assessed clinically and radiographically. Plasma ceramides (Cer) and phosphocholines (PC) were quantified by LC-MS/MS, and cardiovascular risk scores (CERT1 and CERT2) were calculated.</p><p><strong>Results: </strong>Several Cer:Cer and Cer:PC ratios increased with periodontitis stage, grade and edentulousness, whereas most PC species decreased. Cer(d18:1/16:0)/PC(16:0/22:5), Cer(d18:1/18:0)/Cer(d18:1/24:0), Cer(d18:1/18:0)/PC(16:0/22:5) and Cer(d18:1/24:1)/PC(16:0/22:5) were associated with all periodontal measures. CERT2 was independently associated with both stage and grade. In cross-sectional analyses, periodontitis was associated with multiple lipid species both directly and indirectly through systemic inflammation. In longitudinal analyses, baseline lipid levels did not predict periodontitis progression.</p><p><strong>Conclusion: </strong>Periodontitis severity was found to be associated with systemic ceramide and phospholipid profiles, particularly Cer:PC ratios, whereas baseline lipid levels were not associated with subsequent disease progression. These findings suggest that systemic inflammation substantially mediates the relationship between periodontitis and circulating lipid species, linking periodontitis with broader disturbances in lipidomic homeostasis.</p>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":" ","pages":""},"PeriodicalIF":8.3,"publicationDate":"2026-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148663975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":" Porphyromonas gingivalis Drives Trained Immunity via the Glycolysis– SIRT1 Axis to Aggravate Colitis","authors":"Bin Lu, Hanxin Que, Tianhao Chen, Pengcheng Ye, Mengting Wu, Li Yu, Fangchun Shou, Chengxiang Luo, Junjie Bao, Chenyue Jiang, Cheng Zheng, Yi Wang, Hui Deng","doi":"10.1111/jcpe.70179","DOIUrl":"https://doi.org/10.1111/jcpe.70179","url":null,"abstract":"Aim To investigate whether <jats:styled-content style=\"fixed-case\"> <jats:italic>Porphyromonas gingivalis</jats:italic> </jats:styled-content> aggravates colitis through trained immunity, and to elucidate the underlying metabolic and epigenetic mechanisms. Materials and Methods In vivo, bone marrow from <jats:styled-content style=\"fixed-case\"> <jats:italic>P. gingivalis</jats:italic> </jats:styled-content> ‐infected mice was transplanted into recipient mice, followed by induction of colitis. In vitro, macrophages trained with <jats:styled-content style=\"fixed-case\"> <jats:italic>P. gingivalis</jats:italic> </jats:styled-content> were subjected to lipopolysaccharide (LPS) re‐stimulation to assess inflammatory cytokine production. Histone acetylation and untargeted metabolomic analysis were examined in <jats:styled-content style=\"fixed-case\"> <jats:italic>P. gingivalis</jats:italic> </jats:styled-content> ‐infected macrophages. Results Recipient mice transplanted with bone marrow from <jats:styled-content style=\"fixed-case\"> <jats:italic>P. gingivalis</jats:italic> </jats:styled-content> ‐infected donors developed more severe colitis. Moreover, macrophages trained with <jats:styled-content style=\"fixed-case\"> <jats:italic>P. gingivalis</jats:italic> </jats:styled-content> showed an enhanced inflammatory response upon LPS re‐stimulation. Mechanistically, histone H3 lysine 27 acetylation (H3K27ac) was markedly increased following <jats:styled-content style=\"fixed-case\"> <jats:italic>P. gingivalis</jats:italic> </jats:styled-content> infection and remained elevated after its removal. Furthermore, <jats:styled-content style=\"fixed-case\"> <jats:italic>P. gingivalis</jats:italic> </jats:styled-content> drives a metabolic shift towards glycolysis, which reduces nicotinamide adenine dinucleotide (NAD <jats:sup>+</jats:sup> ) levels and sirtuin 1 (SIRT1) activity, thereby attenuating SIRT1‐mediated deacetylation of H3K27ac. Inhibiting glycolysis or activating SIRT1 reversed <jats:styled-content style=\"fixed-case\"> <jats:italic>P. gingivalis</jats:italic> </jats:styled-content> ‐induced trained immunity and alleviated the aggravated colitis phenotype. Conclusions <jats:styled-content style=\"fixed-case\"> <jats:italic>P. gingivalis</jats:italic> </jats:styled-content> induces trained immunity via the glycolysis–SIRT1 axis and aggravates colitis. These findings provide a novel explanation for the persistent risk of colitis associated with periodontitis.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"16 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148596263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Site‐Resolved Gingival Microcirculation and Colour Features in Health and Early Inflammation","authors":"Mengning Bi, Hairui Li, Yu Xie, Xiaoyu Yu, Wen Gu, Andrea Roccuzzo, Yuan Li, Maurizio S. Tonetti","doi":"10.1111/jcpe.70171","DOIUrl":"https://doi.org/10.1111/jcpe.70171","url":null,"abstract":"Aim To characterise site‐level gingival microcirculation in health and early inflammation without clinical attachment loss (CAL), and to evaluate its relationship with probing‐derived clinical parameters and scan‐derived gingival colour metrics. Materials and Methods In this cross‐sectional observational study, gingival microcirculation was assessed at five maxillary anterior interdental papillae and matched keratinised gingival (KG) sites using a combined laser Doppler flowmetry and tissue spectrophotometry system (O2C), providing oxygen saturation (SO <jats:sub>2</jats:sub> ), relative haemoglobin (Hb) and blood flow (Flow). Gingival papilla colour was extracted from intraoral scans and converted to CIE <jats:italic>L</jats:italic> * <jats:italic>a</jats:italic> * <jats:italic>b</jats:italic> * metrics. The primary analysis was restricted to sites without clinical attachment loss (CAL = 0 mm), with BOP used as a site‐level indicator of gingival inflammation. Site comparisons, correlations and mixed‐effects models were performed. Results Seventy‐four young adults were included. Three‐hundred and forty‐six papilla sites and their matched KG sites were analysed. KG sites showed higher SO <jats:sub>2</jats:sub> , Hb and Flow than papilla sites. Papilla microcirculation showed substantial heterogeneity, with both between‐participant and within‐participant/site‐level variance components. Clinical alignment was limited: papillary Hb was associated with probing depth (PD) and bleeding on probing (BOP), whereas Flow showed weaker associations and SO <jats:sub>2</jats:sub> showed no significant association. In mixed‐effects models, conventional clinical indices accounted for only a small proportion of the variance in papillary microcirculation. Among colour metrics, lightness ( <jats:italic>L</jats:italic> *) showed the clearest clinical pattern, being inversely associated with BOP, PD and papillary Hb. Conclusions In early gingival inflammation, papillary microcirculation is a measurable and heterogeneous site‐level feature that is only partly captured by routine probing‐derived parameters. Scan‐derived gingival colour, particularly lightness, provides complementary information on local inflammatory status. Additional studies are needed to properly characterise microcirculation and tissue colour across the full health–disease spectrum.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"120 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148589023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Dietary Inflammatory Index and Periodontal Inflammation in Community-Dwelling Older Adults in Japan: The Otassha Study","authors":"Akihiro Yuguchi,&nbsp;Masanori Iwasaki,&nbsp;Maki Shirobe,&nbsp;Yurie Mikami,&nbsp;Misato Hayakawa,&nbsp;Keiko Motokawa,&nbsp;Yoshiko Motohashi,&nbsp;Yuki Ohara,&nbsp;Ayako Edahiro,&nbsp;Hisashi Kawai,&nbsp;Yoshinori Fujiwara,&nbsp;Kazushige Ihara,&nbsp;Yutaka Watanabe,&nbsp;Hiroyuki Sasai,&nbsp;Shuichi Obuchi,&nbsp;Hirohiko Hirano","doi":"10.1111/jcpe.70140","DOIUrl":"10.1111/jcpe.70140","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To investigate the association between the dietary inflammatory index (DII) and periodontal inflammation (periodontal inflamed surface area [PISA]) in community-dwelling older adults in Japan.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>DII scores, derived from a validated questionnaire-based dietary assessment, were categorised into quartiles. Linear regression models were used to assess the associations between DII (exposure) and log-transformed PISA (outcome) calculated from full-mouth periodontal examinations. Restricted cubic spline (RCS) models were applied to examine potential nonlinearity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the 466 participants (mean age = 73.1 years), the median PISA was 37.8 mm², and the median values for whole-mouth average probing pocket depth, clinical attachment loss and bleeding on probing were 1.8 mm, 2.0 mm and 3.3%, respectively. After adjustment for covariates, participants in the third [regression coefficient (95% confidence interval) = 0.49 (0.03–0.95)] and fourth [0.83 (0.34–1.32)] DII quartiles had significantly higher PISA values. Although the test for nonlinearity was not significant, the RCS analysis revealed a largely flat association below DII ≈ −1.5, followed by a near-linear increase with increasing DII.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Diets with greater inflammatory potential were associated with higher periodontal inflammatory burdens among older adults in Japan. DII may serve as a modifiable dietary indicator to support periodontal health in ageing populations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 8","pages":"1312-1322"},"PeriodicalIF":8.3,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147941408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontitis and Stroke Onset, Medical Costs and Length of Hospital Stay: A 5-Year Cohort Study","authors":"Mizuki Saito,&nbsp;Yoshihiro Shimazaki,&nbsp;Toshiya Nonoyama,&nbsp;Yoshinori Inamoto","doi":"10.1111/jcpe.70153","DOIUrl":"10.1111/jcpe.70153","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To evaluate the longitudinal association between periodontitis and stroke onset using medical claims data and also to assess the relationship between periodontitis and stroke-related medical costs and length of hospital stay.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>In total, 1997 individuals aged 75 or 80 years were included. The association between periodontitis and stroke onset over a 5-year period was evaluated using a Cox proportional hazards model, with stroke onset as the dependent variable and periodontitis as the independent variable. Restricted mean survival time (RMST) was compared across periodontitis severity groups. In addition, generalised linear models were used to evaluate the relationships of periodontitis with stroke-related medical costs and length of hospital stay among participants who experienced a stroke during the follow-up period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Participants with severe periodontitis had a significantly higher hazard ratio for stroke onset after 23 months of follow-up compared to those without periodontitis and exhibited a significantly reduced RMST for stroke onset. Among 80-year-old participants, those with periodontitis incurred significantly higher treatment costs and spent more days in health care compared to participants without periodontitis. No significant associations were observed among 75-year-old participants.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our findings suggest that periodontitis may be associated with the incidence and severity of stroke, potentially impacting the increased medical care costs associated with stroke.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 8","pages":"1323-1331"},"PeriodicalIF":8.3,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70153","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148239474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Assessment of Tooth Survival After Treatment of Endodontic-Periodontal Lesions: A Retrospective Study","authors":"Fumihiko Kimura,&nbsp;Risako Mikami,&nbsp;Koji Mizutani,&nbsp;Daisuke Kido,&nbsp;Kohei Takeda,&nbsp;Keita Nakagawa,&nbsp;Shu Takemura,&nbsp;Hiromi Kominato,&nbsp;Natsumi Saito,&nbsp;Tatsuro Seike,&nbsp;Eri Sakaniwa,&nbsp;Ayu Sugiyama,&nbsp;Tomoki Nogami,&nbsp;Satoshi Watanabe,&nbsp;Jun Aida,&nbsp;Takanori Iwata","doi":"10.1111/jcpe.70142","DOIUrl":"10.1111/jcpe.70142","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This retrospective cohort study aimed to identify pretreatment prognostic factors for tooth survival in teeth with endodontic-periodontal lesions (EPLs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Teeth with EPLs treated according to a standardised clinical protocol involving periodontal and endodontic treatments were included. Clinical parameters were measured, and the EPL grade was classified according to the 2017 World Workshop criteria. Based on the radiographic characteristics, lesions were categorised as I-shaped (unilateral intrabony defect without apparent apical radiolucency), J-shaped (unilateral intrabony defect with apical radiolucency) and U-shaped (bilateral intrabony defects with apical radiolucency). Survival-time analysis was performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 187 teeth included, 117 survived over the mean observation period of 3.1 ± 2.1 years (maximum, 8.4 years). The estimated 1- and 5-year tooth survival rates were 83.8% and 58.9%, respectively. Multivariate analysis identified age, EPL grade, probing depth (PD), periapical index, bone loss and I-J-U subclassification as significant prognostic factors for tooth survival. The I-J-U subclassification was significantly associated with tooth survival, suggesting its potential value in prognostic assessment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This retrospective cohort study identified age, EPL grade, PD and radiographic shape of bone loss as predicting factors for tooth survival in teeth with EPLs.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 8","pages":"1289-1300"},"PeriodicalIF":8.3,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70142","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147972829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonsteroidal Anti-Inflammatory Drugs and the Risk of Periodontitis Among Adults With Osteoarthritis: A Target Trial Emulation","authors":"Ignacio Leiva-Escobar,&nbsp;Aiswarya Puzhakkara Chennas,&nbsp;Zoheir Alayash,&nbsp;Stefan Lars Reckelkamm,&nbsp;Birte Holtfreter,&nbsp;Thomas Kocher,&nbsp;Sebastian-Edgar Baumeister,&nbsp;Michael Nolde","doi":"10.1111/jcpe.70145","DOIUrl":"10.1111/jcpe.70145","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Nonsteroidal anti-inflammatory drugs (NSAIDs) may mitigate periodontal tissue breakdown through cyclooxygenase (COX) inhibition; however, their long-term effects on the risk of periodontitis remain unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We emulated target trials using US electronic health records (1995–2019) to compare the 5-year risk of incident periodontitis among adults with osteoarthritis-initiating NSAIDs versus acetaminophen. Eligible individuals had osteoarthritis, no prior periodontitis and no recent use of either medication. We estimated the risk of periodontitis using a pooled logistic regression model, adjusting for confounding via inverse probability weighting. Additionally, we conducted a subgroup analysis by NSAID COX selectivity, along with a negative control outcome analysis examining dental caries.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The 5-year risk difference (NSAIDs – acetaminophen) was 0.13% (95% CI: −0.32%, 0.58%). Similar findings were observed across subgroups compared with acetaminophen: non-selective NSAIDs, 0.11% (95% CI: −0.36%, 0.59%); preferential COX-2 NSAIDs, 0.10% (95% CI: −0.71%, 0.92%). The 5-year risk difference for dental caries was −0.27% (95% CI: −1.01%, 0.50%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>We found no evidence that initiating NSAIDs, compared with acetaminophen, influenced the 5-year risk of periodontitis, and no differences by COX selectivity. Our findings align with inconclusive evidence from smaller studies on NSAIDs as adjuncts in periodontitis treatment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 8","pages":"1301-1311"},"PeriodicalIF":8.3,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70145","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148005324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salivary Microbiota From a Periodontitis Donor Is Associated With Altered IgA-Related Immune Features in Germ-Free Mice","authors":"K. Irie,&nbsp;T. Azuma,&nbsp;R. Minoshima,&nbsp;Y. Mochida,&nbsp;R. Yamada,&nbsp;K. Nanashima,&nbsp;S. Fuchida,&nbsp;N. Kubota,&nbsp;K. Tsukinoki,&nbsp;Y. Sato,&nbsp;T. Tomofuji,&nbsp;T. Yamamoto","doi":"10.1111/jcpe.70146","DOIUrl":"10.1111/jcpe.70146","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The oral microbiota has been implicated in mucosal immune regulation; however, its causal impact on salivary gland–associated immune features remains incompletely understood. In this proof-of-concept study, germ-free (GF) mice were colonised with salivary microbiota derived from either a periodontitis donor or a periodontally healthy donor, and IgA-associated immune readouts were evaluated across multiple compartments.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>GF mice were orally colonised with saliva-derived microbiota from a periodontitis patient or a periodontally healthy donor (or PBS). Total IgA in saliva, serum and faeces were quantified by ELISA. Cervical lymph nodes and blood were analysed by flow cytometry. Submandibular glands underwent histology and bulk RNA-seq.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Mice receiving microbiota from a periodontitis donor exhibited altered IgA levels in saliva, serum and faeces, increased faecal lipocalin-2, changes in innate immune cell distributions and increased CD138⁺ cell signals and IgA immunoreactivity in the submandibular glands. Transcriptomic analysis revealed heterogeneous expression of individual IgA-related genes, with coordinated patterns observed at the level of IgA/mucosal defence–related gene sets.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings indicate that salivary microbiota from a periodontitis donor are associated with altered IgA-related immune features under GF conditions. While limited by the use of a single donor per group, this study provides proof-of-concept evidence supporting a potential role of oral microbiota in shaping salivary gland–associated immune characteristics.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 8","pages":"1355-1363"},"PeriodicalIF":8.3,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148005336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Outcomes of 6-mm Short Implants Supporting Splinted Crowns in Posterior Regions: A 12-Year Prospective Multi-Centre Single-Cohort Study","authors":"Diyuan Wei,&nbsp;Huiping Sui,&nbsp;Han Zhang,&nbsp;Zhihui Tang,&nbsp;Xiao Zhang,&nbsp;Huanxin Meng,&nbsp;Jie Han","doi":"10.1111/jcpe.70144","DOIUrl":"10.1111/jcpe.70144","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To assess the clinical, radiographic and patient-reported outcomes (PROs) of 6-mm short implants supporting splinted crowns in posterior regions at 12 years following early prosthetic loading.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This prospective study enrolled 45 patients (95 implants; Ø4 × 6 mm) across three centres. Participants received 2–3 implants in posterior regions, with all prosthetically rehabilitated via screw-retained splinted crowns following a 6-week healing period. Clinical and radiographic parameters were assessed at implant placement, prosthetic loading and post-loading intervals (6/12/24/36/60/96/144 months). Biological and mechanical complications were documented at each revisit. PROs were collected at the 12-year follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Thirty-nine patients completed the 12-year follow-up, including three evaluated remotely. Mean marginal bone level change was −0.09 ± 0.26 mm. Seven implants failed, with four occurring before early loading and the other three after 5 years post loading. The cumulative survival rate was 92.6%. Prevalences of peri-implant mucositis and peri-implantitis were 37.8% and 2.7% at the implant level, corresponding to 50.0% and 5.6% at the patient level, respectively, while mechanical complication prevalence was 31.1%. Patients were highly satisfied with implant treatment at the final follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Six-mm short implants supporting early loaded splinted crowns in posterior regions could achieve stable clinical outcomes and marginal bone levels with high satisfaction over a 12-year follow-up period.</p>\u0000 \u0000 <p><b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT01346696</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 8","pages":"1278-1288"},"PeriodicalIF":8.3,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148030866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic Antibiotics in the Surgical Treatment of Peri-Implantitis: Impact on the Salivary Microbiome","authors":"Caroline Riben Grundström,&nbsp;Bodil Lund,&nbsp;Nagihan Bostanci,&nbsp;Angelika Silbereisen,&nbsp;Alexandra Pennhag,&nbsp;Ina Schuppe Koistinen,&nbsp;Yinghua Zha,&nbsp;Anastasios Damdimopoulos,&nbsp;Georgios N. Belibasakis,&nbsp;Margareta Hultin","doi":"10.1111/jcpe.70143","DOIUrl":"10.1111/jcpe.70143","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To exploratorily compare the shifts in the salivary microbiome composition after administration of two combined systemic antibiotic regimens used in the surgical treatment of peri-implantitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A subset of 27 patients treated surgically for peri-implantitis with an adjunctive 7-day course of systemic antibiotics were included (group A, amoxicillin and metronidazole; group B, phenoxymethylpenicillin and metronidazole). Unstimulated saliva was collected before surgery followed by 8 days, 14 days, 6 months and 12 months post surgery. Microbiome profiling was performed using standardised and automated pipelines for DNA extraction and whole genome shotgun sequencing (WGS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>WGS identified 498 species across 194 genera and 16 phyla, with Firmicutes and Actinobacteria being the most abundant. A distinct decrease in alpha diversity was observed on Day 8 relative to baseline across both antibiotic regimens, with signs of richness recovery by Day 14. Alpha and beta diversity analyses showed no statistically significant differences between interventions over the 12-month observation period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Both adjunctive antibiotic regimens applied in the surgical treatment of peri-implantitis caused comparable ecological disturbances in the salivary microbiome, with no microbiological or clinical evidence supporting the superiority of one regimen over the other.</p>\u0000 \u0000 <p><b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT02185209</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 8","pages":"1265-1277"},"PeriodicalIF":8.3,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70143","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148015740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}