Journal of Clinical Periodontology最新文献

{"title":"The Association of Periodontal Inflammation and Systemic Health Indicators: A Machine Learning Approach","authors":"Yumeng Yan,&nbsp;Praveen Sharma,&nbsp;Jeanie Suvan,&nbsp;Francesco D'Aiuto","doi":"10.1111/jcpe.70000","DOIUrl":"10.1111/jcpe.70000","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The relationship between oral and systemic inflammation has profound implications for understanding the broader health impacts of periodontitis. The aim of this study was to (a) explore the association between periodontal inflammation and markers of systemic inflammation and metabolic health, and (b) preliminarily assess periodontal status based on systemic health indicators using machine learning techniques.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data from a cross-sectional cohort (<i>N</i> = 667) were modelled (simple/multiple linear, fractional polynomial, logistic and random forest regression) to examine the association between systemic and periodontal measures. Three classifiers—random forest (RF), support vector machine (SVM) and gradient boosting (GB)—were used using periodontal inflamed surface area (PISA) and demographic and anthropometric variables (age, gender, ethnicity, body mass index [BMI] and smoking habits) as inputs to predict systemic inflammation (defined using serum C-reactive protein [CRP] levels). The best performing classification models (evaluated using area under the curve, AUC analyses) were validated using a second nationally representative dataset from the National Health and Nutrition Examination Surveys (NHANES) 2001–2002 and 2003–2004 combined datasets (<i>N</i> = 2288). Next, RF, SVM and GB were employed incorporating a set of systemic parameters (including serum CRP and lipid profiles) to predict the diagnosis of periodontitis. The best performing classification models were then validated using the NHANES 2009–2010 (<i>N</i> = 664) dataset.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A nonlinear trend of CRP levels and PISA was confirmed by fractional polynomial regression (<i>p</i> = 0.008). Further, multiple linear regression analyses (adjusted for age, gender, ethnicity, BMI and smoking habits) confirmed a statistically significant relationship between log-transformed CRP levels and PISA (<i>p</i> &lt; 0.0001). Logistic regression confirmed a relationship between PISA and low-density lipoprotein (LDL) in both crude and adjusted models. Among the classification models, SVM showed the highest performance in distinguishing CRP &lt; 2 mg/L from CRP ≥ 2 mg/L (AUC = 0.71). The SVM model was successfully replicated in the NHANES 2001–2002 and 2003–2004 waves (AUC = 0.74). Prediction of periodontitis status (case vs. control) based on systemic indicators using the SVM model achieved the best performance with a mean AUC of 0.82. This was partially confirmed after external validation using the 2009–2010 NHANES dataset (AUC of 0.72).</p>\u0000 </section>\u0000 \u0000 ","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 10","pages":"1466-1477"},"PeriodicalIF":6.8,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70000","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Placement of Patient-Specific One-Piece Drill-Free Fully Digital Designed Dental Implants: A Feasibility Study","authors":"Giuseppe Alexandre Romito,&nbsp;Mohamed Ahmed Hassan,&nbsp;Marina Nogueira de Castro Galvão Corrente,&nbsp;Julia Dahdal Aoun,&nbsp;Vitor Marques Sapata,&nbsp;Roger Nishyama,&nbsp;Cristina Cunha Villar","doi":"10.1111/jcpe.14204","DOIUrl":"10.1111/jcpe.14204","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>CBCT and CAD/CAM technologies have allowed the development of patient-specific implants requiring no drilling. This prospective study evaluated the safety and effectiveness of a novel, drill-free, one-piece root-analogue implant designed using a digital workflow and manufactured additively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Patients with non-restorable maxillary anterior or premolar teeth requiring extraction and implant placement were included. Implant design was based on pre-extraction cone-beam computed tomography (CBCT) and optical impressions of the target tooth, adjacent teeth and opposing dentition, and post-extraction scanning of the extracted tooth. Within 14 days post extraction, the implant was designed, manufactured and placed into the alveolar socket, and a temporary crown was installed out of occlusion. The final crown was installed after 3 months. Clinical parameters, including plaque index, gingival index, bleeding on probing, suppuration, peri-implant mucosal margin position, probing depth, probing depth relative to the implant platform and keratinised tissue, were collected at 3, 6, 9, 12 and 24 months post loading. Radiographic measurements as well as patient- and clinician-reported outcomes were also assessed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study cohort comprised 12 patients. The cumulative implant survival and success rates reached 100% and 90%, respectively. Clinical and radiographic parameters consistently indicated healthy peri-implant tissues. Patient-reported outcomes demonstrated high satisfaction and minimal discomfort. Visual analogue scale (VAS) scores for overall satisfaction remained high, with a median of 10 at final restoration delivery (95% CI: 10.00–10.00) and at the 24-month follow-up (95% CI: 9.70–10.01).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These patient-specific, root-analogue implants demonstrated both safety and effectiveness, along with high patient satisfaction rates up to 24 months post loading.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 10","pages":"1374-1385"},"PeriodicalIF":6.8,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14204","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Surgical Periodontal Therapy Modulates Oral Microbiome in Primary Immunodeficient Children","authors":"Abish S. Stephen,&nbsp;Stacy Worrall,&nbsp;Cheryl Somani,&nbsp;Robert P. Allaker,&nbsp;Janet Davies,&nbsp;Luigi Nibali,&nbsp;Nikolaos Donos","doi":"10.1111/jcpe.14201","DOIUrl":"10.1111/jcpe.14201","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aim</h3>\u0000 \u0000 <p>Primary Immunodeficiencies (PIDs) arise from rare genetic defects affecting humoral and cellular immunity, which can lead to reduced dental plaque control. This study aimed to characterise the subgingival dental plaque microbiome in neutropenic PID children compared to healthy controls and assess their response to non-surgical periodontal therapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Subgingival plaque was collected from three first molars and one first incisor at baseline and 6 months post therapy from children with PID (<i>n</i> = 24) and systematically healthy control participants (<i>n</i> = 24) who were recruited from Great Ormond Street Hospital and Barts Health NHS Trust, respectively. The subgingival microbiome was profiled using an Illumina metabarcoding approach on the bacterial 16S rRNA gene V1–V2 region.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Significant shifts in community structure were observed post therapy, as measured by alpha and beta diversities. An increase in <i>Rothia</i> spp., <i>Neisseria</i> spp. and <i>Actinomyces</i> spp. was noted in PID children post therapy, consistent with clinical improvements. Baseline blood absolute neutrophil counts in PID children were positively associated with \u0000 <i>Streptococcus cristatus</i>\u0000 and <i>Gemella</i> spp., and negatively with <i>Saccharibacteria, Capnocytophaga</i> and <i>Porphyromonas</i> spp., highlighting key host–microbial relationships.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Non-surgical periodontal therapy modulated the subgingival microbiota in neutropenic PID children, revealing novel host–microbial interactions important for the oral microbiome in health.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 10","pages":"1410-1418"},"PeriodicalIF":6.8,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14201","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Loci Associated With Periodontitis: The FinnGen Study Based on National Health Registers","authors":"Aino Salminen,&nbsp;Kati Hyvärinen,&nbsp;Jarmo Ritari,&nbsp;Ana Caetano,&nbsp;Oleg Kambur,&nbsp;Päivi Mäntylä,&nbsp;Mustafa Yilmaz,&nbsp;Juha Sinisalo,&nbsp;FinnGen,&nbsp;Markus Perola,&nbsp;Aki Havulinna,&nbsp;Luigi Nibali,&nbsp;Ulvi Kahraman Gürsoy,&nbsp;Pirkko J. Pussinen","doi":"10.1111/jcpe.14193","DOIUrl":"10.1111/jcpe.14193","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To perform a genome-wide association study (GWAS) for periodontitis in the FinnGen cohort, as genetic factors contribute to periodontitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>We included nearly 250,000 Finnish individuals who had visited a dentist in the public healthcare sector for a clinical oral examination. We designed three periodontitis phenotypes based on diagnosis and procedure codes and CPI indexes in national health registers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We identified 11 independent genetic loci associated with periodontitis, among which 6 were common and novel. A locus near the <i>FST</i> gene was associated with two phenotypes, whereas other lead SNPs were located near <i>ARL15</i>, <i>MFHAS1</i>, <i>DEFB130A</i> and <i>APOE</i>. Additionally, all phenotypes in the discovery and replication cohorts were associated with genetic variations in the HLA region. Furthermore, imputed HLA allele frequencies identified independent associations between <i>HLA-DRB1</i>, <i>HLA-DPB1</i> and <i>HLA-DQA1</i> and periodontitis. Based on single-cell RNA sequencing, the expression of genes near our lead SNPs across all three phenotypes was particularly enriched in gingival cell lineages important in the pathogenesis of periodontitis. Phenotypical and genetic correlations revealed associations between periodontitis and bacterial diseases, as well as autoimmune and cardiometabolic phenotypes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our GWAS suggests that genetic variation contributing to immune dysregulation is involved in the pathogenesis of periodontitis, which has considerable genetic similarity with other complex traits.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 9","pages":"1263-1275"},"PeriodicalIF":6.8,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14193","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144664263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Periodontal Benefits of Alveolar Ridge Augmentation With Xenograft Following Third Molar Extraction: A Randomised Controlled Trial","authors":"Su Sheng Quach,&nbsp;Nigel Johnson,&nbsp;Raahib Dudhia,&nbsp;Anthony Puljich,&nbsp;Sašo Ivanovski,&nbsp;Ryan S. B. Lee","doi":"10.1111/jcpe.14205","DOIUrl":"10.1111/jcpe.14205","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate the effect of deproteinised bovine bone mineral with collagen (DBBM-C) grafting on periodontal healing at the distal aspect of the second molar (D2M) during adjacent third molar extraction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Forty-two sites in 28 patients were randomly allocated into two groups. The test group (18 sites) received DBBM-C grafting during extraction, whereas the control group (24 sites) received extraction alone. The patients were reviewed 6 months postoperatively, and the D2M and extraction sites were evaluated by both linear and volumetric cone beam computed tomography measurements.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Nine patients dropped out (14 sites) and two patients were excluded (4 sites), leaving a total of 17 patients (24 sites) who were reviewed after 6 months. Both groups showed significant healing when examining the linear measurements (except at the disto-lingual aspect of the second molar) and the defined volumes of interest. There were, however, no significant differences between the groups in the linear or volumetric outcome analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Within the limitations of the study, the use of DBBM-C during third molar extraction did not improve periodontal healing at the D2M. This trial was registered in April 2020 in the Australian New Zealand Clinical Trials Registry under code ACTRN12620000497909 (https://anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12620000497909).</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 10","pages":"1419-1429"},"PeriodicalIF":6.8,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14205","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144622174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stability of Augmented Bone and Its Influencing Factors After Simultaneous Guided Bone Regeneration With Implant Placement in the Posterior Mandible: A Retrospective Study","authors":"Xiaoyu Chen,&nbsp;Wenting Qi,&nbsp;Siyuan Wang,&nbsp;Antian Xu,&nbsp;Hongye Lu,&nbsp;Xiaoting Shen,&nbsp;Fuming He","doi":"10.1111/jcpe.14206","DOIUrl":"10.1111/jcpe.14206","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To analyse the stability of augmented bone and its influencing factors after simultaneous guided bone regeneration (GBR) with implant placement in the posterior mandible.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A total of 165 implants in 102 patients were included. General information, peri-implant soft-tissue parameters and complications were recorded. Cone-beam computed tomography images at preoperative (T0), immediate postoperative (T1), post-healing (T2) and the latest follow-up (T3) were collected. Buccal bone width, height, bone distance (BD) and augmented bone volume (ABV) were assessed. Bone augmentation range was classified into inside-contour (IC) group and outside-contour (OC) group based on BD values. Factors influencing the augmented bone volume resorption rate (ABV%) were analysed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>During the follow-up period of 12–88 months, the mean ABV% was 47.56% ± 20.29%, predominantly occurring between T1 and T2. The OC group showed higher ABV% compared to the IC group (<i>p</i> &lt; 0.001). BD of the IC and 0–1 mm OC groups was less than 0, while BD of the 1–2 and &gt; 2 mm OC groups was near 0 at T3. Bone augmentation range (<i>p</i> &lt; 0.001), non-contained defects (<i>p</i> = 0.001) and 2-mm healing abutments (<i>p</i> = 0.008) significantly influenced ABV%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Simultaneous GBR with implant placement in the posterior mandible provided predictable volumetric stability of the augmented bone. OC grafts resorbed towards individual phenotypical dimensions, whereas 1–2 mm over-augmentation might optimise contour maintenance. Non-contained defects compromised volumetric stability, while the 2-mm healing abutments enhanced stability compared to cover screws.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 10","pages":"1430-1441"},"PeriodicalIF":6.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144603083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Periodontal Condition With Serum C-Reactive Protein Levels: The Role of Serum Apolipoproteins' Concentration","authors":"Anniina Haro,&nbsp;Tuomas Saxlin,&nbsp;Anna Liisa Suominen,&nbsp;Antti Jula,&nbsp;Pekka Ylöstalo","doi":"10.1111/jcpe.14202","DOIUrl":"10.1111/jcpe.14202","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To investigate whether the systemic inflammatory response against inflammatory conditions in the periodontium is related to serum apolipoprotein B (ApoB) and A1 (ApoA1) concentrations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>The study consisted of the Health 2000 Survey participants (<i>n</i> = 2709) aged 30–49 years. The inflammatory condition of the periodontium was assessed by means of the number of teeth with deepened (≥ 4 mm) and deep (≥ 6 mm) periodontal pockets. Systemic inflammation was measured by serum C-reactive protein (CRP) levels. The role of ApoB and ApoA1 was studied by performing regression analyses and stratified analyses (according to the median values).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In logistic regression analyses, the number of teeth with deepened (≥ 4 mm) periodontal pockets was associated with serum CRP levels among those participants whose serum ApoB concentration was ≥ 1.12 g/L. When the participants' ApoB concentration was &lt; 1.12 g/L, such an association between deepened periodontal pockets and CRP was not observed. The direction or strength of the association between periodontal pockets and CRP was not essentially different in the ApoA1 strata.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Systemic response against poor periodontal condition varied between individuals. The variation appeared to be related more to the serum concentration of ApoB than ApoA1.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 10","pages":"1454-1465"},"PeriodicalIF":6.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14202","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144603085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KAT6A Promotes Macrophage Inflammation and Periodontitis","authors":"Shi-Jia Huang,&nbsp;Shuo Xu,&nbsp;Hui-Lin Ye,&nbsp;Lu-Jun Zhou,&nbsp;Yong-Li Wang,&nbsp;Sheng-Zhong Duan","doi":"10.1111/jcpe.14203","DOIUrl":"10.1111/jcpe.14203","url":null,"abstract":"<div>\u0000 \u0000 <p>Both epigenetic modification and immunoregulation play important roles in periodontitis (PD). However, the function of macrophage lysine acetyltransferase 6A (KAT6A) in PD remains unknown. In this study, we first analysed single-cell RNA sequencing data and demonstrated up-regulated KAT6A expression in periodontal tissue macrophages of PD patients. Subsequently, macrophage KAT6A knockout (MK6AKO) mice were generated and subjected to PD induction by a combination of molar ligation and application of \u0000 <i>Porphyromonas gingivalis</i>\u0000 (<i>Pg</i>). Morphological analyses showed significantly decreased alveolar bone resorption in MK6AKO mice, and qRT-PCR analysis showed markedly attenuated expression of inflammatory genes in the gingiva of MK6AKO mice compared to littermate mice after PD induction. RNA-seq of peritoneal macrophages stimulated with <i>Pg</i> lipopolysaccharides (<i>Pg</i>-LPS) unveiled down-regulation of inflammatory pathways, particularly the interleukin 17 pathway in MK6AKO macrophages. Flow cytometry analysis detected a notable reduction of neutrophils in the gingiva of MK6AKO mice after PD induction. Furthermore, using the Cut&amp;tag technique, we identified reduced histone H3K27 acetylation levels at nuclear factor kappa-B binding sites on promoters of interleukin 1β and tumour necrosis factor in MK6AKO macrophages treated with <i>Pg</i>-LPS. In summary, our study highlights the significant role of KAT6A in modulating macrophage phenotypes and the progression of PD, suggesting the therapeutic potential of targeting KAT6A.</p>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 10","pages":"1499-1508"},"PeriodicalIF":6.8,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144593896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Treatment Endpoints After Active Periodontal Treatment and 10 Years of Supportive Periodontal Care: A Retrospective Cohort Study","authors":"Mario Schröder,&nbsp;Max Buchinger,&nbsp;Iulia Dahmer,&nbsp;Peter Eickholz,&nbsp;Hari Petsos","doi":"10.1111/jcpe.14179","DOIUrl":"10.1111/jcpe.14179","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Comparing periodontal stability following active periodontal treatment (APT/T1) and 120 ± 12 months of supportive periodontal care (SPC/T2) using four clinical endpoints (CEPs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>CEP1: pocket probing depths (PPD) ≤ 4 mm, no sites with ≥ 4 mm with bleeding on probing (BOP), and total BOP &lt; 10%; CEP2: no PPD &gt; 4 mm with BOP or PPD ≥ 6 mm; CEP3: ≤ 4 sites with PPD ≥ 5 mm; CEP4: ≤ 5 teeth with PPD ≥ 5 mm. Assuming CEPs are mutually exclusive, patient- and tooth-related parameters (e.g., periodontal tooth loss: PTL) were compared. Using receiver operating characteristic analysis for the prediction of PTL as a cutoff for CEP was assessed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>From 128 patients (age 65.5 ± 10.5 years; 83 stage III, 45 stage IV; 47 grade B, 81 grade C), 7 achieved CEP1, 23 CEP2, 45 CEP3, 23 CEP4, 30 noCEP at T1. At T2, six patients reached CEP1, 37 CEP2, 38 CEP3, 35 CEP4, 12 noCEP. For noCEP, the number of sites with PPD &gt; 5 mm increased significantly, and PTL was higher compared to CEP1, CEP2 and CEP3 (<i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>While achieving CEP1 is possible through comprehensive APT, treating a chronic disease often leads to less ideal CEP2/CEP3. Achieving CEP1, CEP2 or CEP3 after APT made no observable difference regarding PTL.</p>\u0000 \u0000 <p>\u0000 <b>Trial Registration:</b> The study is registered with the United States National Library of Medicine in the clinical trials database (URL: https://clinicaltrials.gov; NCT03048045)</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 10","pages":"1386-1397"},"PeriodicalIF":6.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14179","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endpoints of Periodontal Therapy in Elderly Patients With Stage III/IV Periodontitis and Their Oral Health–Related Quality of Life Following 10 Years of Supportive Periodontal Therapy","authors":"Caspar Victor Bumm,&nbsp;Sophie Gaenesch,&nbsp;Florian Nagler,&nbsp;Iris Frasheri,&nbsp;Falk Schwendicke,&nbsp;Vinay Pitchika,&nbsp;Christina Ern,&nbsp;Richard Heym,&nbsp;Charlotte Wetzel,&nbsp;Matthias Folwaczny,&nbsp;Nils Werner","doi":"10.1111/jcpe.14198","DOIUrl":"10.1111/jcpe.14198","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To investigate clinical endpoints of periodontal therapy after steps 1 and 2 of therapy and their association with oral health–related quality of life (OHRQoL) following long-term supportive periodontal therapy (SPT).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Forty-seven patients receiving SPT for 126 ± 30 months were included. Clinical endpoints of therapy, as proposed by the EFP (PPD ≤ 3 mm, ≤ 5 mm without bleeding on probing), and a treat-to-target endpoint (T2T; ≤ 4 sites with PPD of ≥ 5 mm) were determined following steps 1 and 2 of therapy (T1) and were associated with patients' OHRQoL using the Oral Health Impact Profile (OHIP)-14 as well as tooth loss (TL) and self-reported tooth migration 126 ± 30 months after step 2 (T2).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>One patient achieved the EFP endpoint and 16 achieved T2T, and 30 patients failed to achieve any endpoint at T1. OHRQoL at T2 did not differ significantly between patients achieving or not achieving the endpoints (<i>p</i> = 0.485). Self-reported tooth migration during the examination period was significantly associated with poorer OHRQoL (<i>p</i> = 0.009).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>OHRQoL has become a major subject of periodontal research. Within the limitations of this study, achieving clinical endpoints does not seem to affect patients' OHRQoL following long-term SPT. Patients reporting on tooth migration, however, showed significantly reduced OHRQoL. Besides clinical endpoints, functional and aesthetic complaints of periodontally compromised patients should be considered when evaluating the success of therapy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 10","pages":"1398-1409"},"PeriodicalIF":6.8,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14198","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}