Journal of Clinical Periodontology最新文献

{"title":"Tooth Loss During Supportive Periodontal Care (SPC): A Three Decades Retrospective Study in a University Setting","authors":"M. Cyris,&nbsp;P. Bartels,&nbsp;M. Kahl,&nbsp;C. Springer,&nbsp;S. Sälzer,&nbsp;K. Fawzy El-Sayed,&nbsp;C. E. Dörfer,&nbsp;Li-Li Zhou,&nbsp;C. Graetz","doi":"10.1111/jcpe.70173","DOIUrl":"10.1111/jcpe.70173","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This retrospective cohort study evaluate tooth loss and predictors during exceptionally long term supportive periodontal care (SPC), focusing on residual disease severity at SPC initiation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Seventy patients maintained under SPC for &gt; 30 years were analysed using negative binomial regression (log[SPC-duration] offset) and Cox proportional hazards models (clustered by patient).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Over a mean SPC duration of 36.1 ± 3.0 [30–43] years, 63 patients lost 322 teeth (4.6 ± 4.2 per patient; 0.13 ± 0.12 per patient-year). Despite advanced baseline disease (stage III/IV: 97%), 35-year molar survival was 77% for FI 0 versus 51% for FI II–III. Tooth loss rate was significantly associated with PPD ≥ 6 mm (IRR 1.012; 95% CI 1.003–1.021; <i>p</i> = 0.009) and molar FI II–III (IRR 1.178; 95% CI 1.050–1.321; <i>p</i> = 0.005). A tooth-level Cox model confirmed elevated hazard for PPD ≥ 6 mm (HR 4.02; 95% CI 2.10–7.69) and FI II–III (HR 2.87; 95% CI 1.61–5.11). However, predictive accuracy was modest (PPV 36%–55%), indicating these markers reflect population-level risk rather than individual prognosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Tooth loss remained low over &gt; 30 years of SPC even for molars with advanced FI, while residual disease severity modulated this risk. Given strong survivorship bias (3.3% of eligible patients), generalisability beyond university-based specialist care is limited.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 9","pages":"1481-1490"},"PeriodicalIF":8.3,"publicationDate":"2026-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70173","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148498739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontal Status and the Risk of All-Cause Dementia, Alzheimer's Disease and Vascular Dementia in a Community: The Hisayama Study.","authors":"Michiko Furuta, Tomoyuki Ohara, Satoko Sakata, Mao Shibata, Emi Oishi, Yoshihiko Furuta, Shinya Kageyama, Mikari Asakawa, Yoshihiro Shimazaki, Toru Takeshita, Toshiharu Ninomiya","doi":"10.1111/jcpe.70185","DOIUrl":"https://doi.org/10.1111/jcpe.70185","url":null,"abstract":"<p><strong>Aim: </strong>This study examined the associations of periodontal status with incident dementia and its subtypes in a Japanese community.</p><p><strong>Materials and methods: </strong>The 1396 participants aged ≥ 60 years without dementia were followed for 10 years. Periodontal status at baseline and 5 years was assessed using mean probing pocket depth (PPD), clinical attachment level (CAL) and percentage of bleeding on probing (%BOP), categorized into quartiles. Cox proportional hazards and time-varying Cox models were used.</p><p><strong>Results: </strong>During follow-up, 267 participants developed dementia; 194 and 51 had Alzheimer's disease (AD) and vascular dementia (VaD), respectively. Compared with the lowest quartile, the highest quartiles of PPD, CAL and %BOP at baseline were associated with increased dementia risk (hazard ratio 1.72 [95% confidence interval 1.18-2.46], 1.59 [1.07-2.38] and 1.56 [1.09-2.22], respectively, all p for trend < 0.05). Elevated %BOP was associated with AD risk (p for trend = 0.023). Higher PPD tended to be associated with VaD (p for trend = 0.076). Similar associations for all-cause dementia were observed in time-varying Cox analyses.</p><p><strong>Conclusions: </strong>Poor periodontal status was associated with dementia in older Japanese adults. These findings highlight the potential public health importance of preventing periodontitis to reduce the risk of dementia.</p>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":" ","pages":""},"PeriodicalIF":8.3,"publicationDate":"2026-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148764468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival and Risk Factors of Implants Placed in Sites of Previous Failures—A Nationwide Retrospective Cohort Study","authors":"Thabet Asbi,&nbsp;Doron Haim,&nbsp;Isabelle Meinster,&nbsp;Shai Cahana,&nbsp;Cinthya Massari Grecco,&nbsp;Hadar Better,&nbsp;Ronit Almog,&nbsp;Hadar Zigdon-Giladi,&nbsp;Jamil A. Shibli","doi":"10.1111/jcpe.70162","DOIUrl":"10.1111/jcpe.70162","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To assess the survival rates of dental implants placed in previously failed sites and identify systemic, site-specific and implant-related factors associated with implant loss.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study included all dental implants (177,410 implants in 59,238 patients) placed between 2014 and 2023 within a nationwide dental network. Implant sequence (first, second, third or subsequent placement at the same site) was identified. Implant survival was assessed using Kaplan–Meier analysis and log-rank test. The Andersen–Gill extension of the Cox proportional hazards model was used in a multivariable analysis to identify independent predictors of failure. Separate Andersen–Gill Cox models were fitted for early and late failures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Overall implant survival was 97.5% after a mean follow-up of 4.61 ± 2.72 years. Survival declined progressively with repeated placement, from 97.6% (169,990/174,187) for first implants to 92.2% (2748/2980) for second implants and 88.5% (215/243) for third or subsequent implants (<i>p</i> &lt; 0.001). The hazard of failure was 4.6 times higher for second implants (HR 4.60; 95% CI, 3.98–5.32; <i>p</i> &lt; 0.001) and 5.7 times higher for third or later implants (HR 5.71; 95% CI, 3.68–8.87; <i>p</i> &lt; 0.001), compared to the first implants. Independent predictors of failure included smoking, male sex, penicillin allergy, narrow diameter and maxillary placement. The association between implant sequence and failure differed by time after implantation. The hazard of early failure was 6.80 times higher for second implants (95% CI, 5.78–8.00; <i>p</i> &lt; 0.001) and 9.27 times higher for third or later implants (95% CI, 5.57–15.45; <i>p</i> &lt; 0.001), compared to the first implants. The hazard of late failure was 1.93 times higher for second implants (HR 1.93; 95% CI, 1.40–2.65; <i>p</i> &lt; 0.001) and 2.63 times higher for third or later implants (HR 2.63; 95% CI, 1.24–5.58; <i>p</i> = 0.011), compared to the first implants.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Reimplantation showed relatively favourable survival; however, failure risk increased with each successive implant placed at the same site, particularly early failures. Additionally, smoking, male sex, penicillin allergy, short and narrow implants and maxillary location were independent predictors of failure.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 9","pages":"1459-1471"},"PeriodicalIF":8.3,"publicationDate":"2026-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148440911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ten-Year Results of a Prospective Case Series on Immediately Provisionalized One-Piece Alumina-Toughened Zirconia (ATZ) Oral Implants for Single-Tooth Restoration and Three-Unit Fixed Dental Prostheses","authors":"Ralf-Joachim Kohal,&nbsp;Sebastian B. M. Patzelt,&nbsp;Benedikt C. Spies,&nbsp;Taro Iwasaki,&nbsp;Kei Kubochi,&nbsp;Kirstin Vach,&nbsp;Marc Balmer","doi":"10.1111/jcpe.70156","DOIUrl":"10.1111/jcpe.70156","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>The intention of this 10-year prospective case series investigation was to clinically and radiographically investigate the outcomes of a one-piece alumina-toughened zirconia oral implant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Twenty seven patients received one implant each for single crown restorations (SC), while 13 patients received two implants for a three-unit fixed dental prosthesis (FDP). Eighteen implants were placed in the upper jaw, with four implants in the upper anterior region and nine in the premolar region. The 35 implants of the lower jaw were placed in the premolar (<i>n</i> = 15) or molar region. Follow-up assessments were performed at final restoration insertion (RI), after 1, 5 and 10 years. Peri-implant soft tissue parameters were evaluated, and the peri-implant bone assessed at implant placement, final RI and at the 1-, 5- and 10-year follow-ups. Statistical analysis was conducted to compare differences over time and between groups (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Three implants were lost in the SC patient group and none in the FDP group, yielding a cumulative survival rate of 94.3% for SC and FDP combined. The mean marginal bone loss of the remaining implants was 0.99 mm (implant placement to 10 years: <i>p</i> &lt; 0.001) (0.61 mm for SC and 1.26 mm for FDP; difference: <i>p</i> &lt; 0.05). Probing depth at implant sites increased (<i>p</i> = 0.006), the plaque index remained stable (<i>p</i> = 0.639) and the bleeding showed a significant decrease (<i>p</i> &lt; 0.001), each from RI to the 10-year follow-up after loading. Patients experienced significant improvements in function, aesthetics, sense, speech and self-esteem from pretreatment up to the 10-year follow-up (all <i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The high implant survival rate observed after 10 years substantiates the clinical applicability of the investigated implant system.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 9","pages":"1403-1412"},"PeriodicalIF":8.3,"publicationDate":"2026-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70156","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148271623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Efficacy of Narrow-Diameter Tissue-Level Implants for Molar Replacement: A 1-Year Randomised Controlled Trial","authors":"Hyun-Woo Park,&nbsp;Seung Ha Yoo,&nbsp;Seung-Hyun Park,&nbsp;Jae-Kook Cha,&nbsp;Ui-Won Jung,&nbsp;Mariano Sanz","doi":"10.1111/jcpe.70170","DOIUrl":"10.1111/jcpe.70170","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To compare 1-year clinical and radiographic outcomes of narrow- versus wide-diameter tissue-level implants for single molar replacement.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This two-arm randomised controlled trial enrolled 20 patients (23 implants) in one sextant. Participants received either 3.5-mm narrow-diameter implants (NDI, <i>n</i> = 12) or 5.0-mm wide-diameter implants (WDI, <i>n</i> = 11) using a tissue-level design with computer-guided surgery. The primary outcome was marginal bone loss (MBL) at 1 year assessed by periapical radiographs. Secondary outcomes included operation time, pre-allocation analysis of augmentation requirement, clinical peri-implant parameters, hard- and soft-tissue dimensions, mucosal recession and buccal soft-tissue contour and implant stability. Non-inferiority margin for MBL was 0.5 mm.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>All 23 implants achieved 100% survival. Mean MBL was 0.39 ± 0.29 mm for NDI and 0.48 ± 0.31 mm for WDI (upper 95% confidence interval [CI]: 0.176 mm), confirming non-inferiority of NDI. Operation time was shorter in this cohort for NDI (20.3 ± 9.3 min) than WDI (28.8 ± 15.3 min; one-sided <i>p</i> = 0.049). Peri-implant clinical parameters were comparable.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>NDI showed non-inferiority to WDI in MBL at 1 year while reducing operative time, supporting NDIs as a viable and efficacious alternative for anatomically restricted posterior sites.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>Korean ClinicalResearch Information Service Number: KCT00094155</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 9","pages":"1434-1442"},"PeriodicalIF":8.3,"publicationDate":"2026-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70170","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical, Radiographic and Patient-Centred Outcomes of MINST Versus MIST With Enamel Matrix Derivative in Class II Mandibular Furcation Defects: A Randomised Controlled Trial","authors":"Georgios S. Chatzopoulos,&nbsp;Eleftherios G. Kaklamanos,&nbsp;Ioannis Vouros,&nbsp;Georgios Mikrogeorgis,&nbsp;Aikaterini-Elissavet Doufexi,&nbsp;Lazaros Tsalikis","doi":"10.1111/jcpe.70167","DOIUrl":"10.1111/jcpe.70167","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Aims&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To evaluate whether minimally invasive non-surgical therapy (MINST) with flapless application of enamel matrix derivative (EMD) achieves non-inferior clinical and radiographic outcomes compared to minimally invasive surgical technique (MIST) + EMD, while improving patient-reported outcome measures (PROMs).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Materials and Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Following CONSORT guidelines, 40 patients with mandibular Grade II furcation defects were randomised to MINST (&lt;i&gt;n&lt;/i&gt; = 20) or MIST (&lt;i&gt;n&lt;/i&gt; = 20) with EMD. Probing pocket depth (PPD), clinical attachment level (CAL) and cone-beam computed tomography (CBCT) horizontal/vertical bone loss were assessed at baseline and 9 months. PROMs (visual analogue score [VAS] and Oral Health Impact Profile [OHIP-14]) were recorded longitudinally.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;At 9 months, the mean PPD reduction was 2.20 ± 2.24 mm in the MIST group and 2.15 ± 1.76 mm in the MINST group. The adjusted mean difference was −0.22 mm (95% CI: −1.43 to 0.99 mm). The one-sided non-inferiority &lt;i&gt;p&lt;/i&gt;-value was 0.025. As the upper bound of the confidence interval remained below the prespecified non-inferiority margin, MINST was considered non-inferior to MIST for the primary outcome. When evaluated against the strict +1.0 mm margin, MINST achieved statistical non-inferiority for gingival recession (&lt;i&gt;p&lt;/i&gt; = 0.003) and vertical bone gain (&lt;i&gt;p&lt;/i&gt; = 0.015). However, non-inferiority could not be formally established for CAL (&lt;i&gt;p&lt;/i&gt; = 0.067) or horizontal bone gain (&lt;i&gt;p&lt;/i&gt; = 0.157). PROMs revealed significantly lower root hypersensitivity and improved oral-health-related quality of life in the MINST group at 2 weeks; however, these differences were not sustained at later timepoints.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Within the limitations of this randomised controlled trial, MINST with EMD showed clinical and radiographic outcomes generally comparable to MIST in mandibular Class II furcation defects. While non-inferiority against a strict 1.0 mm margin was successfully established for the primary outcome (PPD) and specific secondary parameters, it could not be formally confirmed for CAL or horizontal bone gain. MINST was associated with significantly improved short-term PROMs during the early healing phase.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Trial Registration&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;ClinicalTrials.gov identifier: NCT05541614&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 ","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 9","pages":"1413-1422"},"PeriodicalIF":8.3,"publicationDate":"2026-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70167","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148415516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-Reported Periodontal Symptoms and Clinical Periodontal Status in Older Adults With and Without Dementia: A Population-Based Diagnostic Accuracy Study","authors":"Tomoaki Mameno,&nbsp;Naoko Otsuki,&nbsp;Satoko Takeuchi,&nbsp;Sho Takeda,&nbsp;Tomoaki Iwayama,&nbsp;Masahide Takedachi,&nbsp;Ryohei Yamamoto,&nbsp;Kazunori Ikebe","doi":"10.1111/jcpe.70168","DOIUrl":"10.1111/jcpe.70168","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate the diagnostic accuracy of self-reported periodontal symptoms compared to clinical periodontal status among older adults with and without dementia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This cross-sectional study included adults ≥ 75 years of age who underwent public dental checkups in Japan. Self-reported gingival bleeding and tooth mobility were assessed as index tests against conceptually matched clinical reference standards: bleeding on probing (BOP) and clinically evaluated tooth mobility (Miller Grade ≥ II), respectively. Dementia status was obtained from health records. Sensitivity, specificity, positive and negative predictive values and area under the receiver operating characteristic curve (AUC) were calculated overall and stratified by dementia status.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 158,990 participants (3.9% with dementia), 61.2% were BOP-positive and 22.5% had Miller Grade ≥ II tooth mobility. Self-reported gingival bleeding showed poor diagnostic accuracy for BOP-positive status (AUC: 0.54; sensitivity: 0.24; specificity: 0.85). Self-reported tooth mobility showed higher but limited accuracy for Miller Grade ≥ II (AUC: 0.66; sensitivity: 0.43; specificity: 0.90), with lower accuracy in participants with dementia (AUC: 0.61) than in those without dementia (AUC: 0.67).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Self-reported periodontal symptoms showed limited diagnostic accuracy in adults aged ≥ 75 years, with the awareness gap most pronounced for tooth mobility in individuals with dementia.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 9","pages":"1472-1480"},"PeriodicalIF":8.3,"publicationDate":"2026-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70168","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Pilot Comparative Study of Multi-Contrast Dental MRI and CBCT: Clinical Correlates of Disease Status and Inflammatory Burden in Periodontitis","authors":"Nouha Tekiki,&nbsp;Arne Lauer,&nbsp;Katharina Hartung,&nbsp;Marietta Kirchner,&nbsp;Luisa Schulte,&nbsp;Hao Li,&nbsp;Alexander Juerchott,&nbsp;Meysam Sohani,&nbsp;Christopher Herpel,&nbsp;Maurice Ruetters,&nbsp;Mathias Nittka,&nbsp;Sabine Heiland,&nbsp;Martin Bendszus,&nbsp;Tim Hilgenfeld","doi":"10.1111/jcpe.70151","DOIUrl":"10.1111/jcpe.70151","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate the reliability of multi-contrast dental MRI (dMRI) for periodontal lesion assessment in comparison to cone-beam computed tomography (CBCT). Associations between imaging findings and clinical indicators of periodontal inflammation (i.e., bleeding on probing [BOP], periodontal probing depth [PPD] and periodontal inflamed surface area [PISA]) were analysed to explore the potential of dMRI to reflect disease status and inflammatory burden.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>In this prospective study, patients with severe periodontitis underwent clinical examination, CBCT and 3T dMRI. Site-level detectability of periodontal osseous defects and/or marrow signal changes at the six standard clinical probing sites per tooth, as well as tooth-level lesion volumetry, were evaluated across CBCT, T1-weighted (T1W), contrast-enhanced T1W and T2-weighted (T2W). Reliability (κ, ICC) and clinical-imaging associations (Kruskal–Wallis and mixed-effect models) were analysed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Nineteen patients with severe periodontitis stages III and IV were included. Reliability of dMRI matched CBCT (site-level <i>κ</i> = 0.631–0.771; tooth-level ICC = 0.832–0.973). Increasing PPD and BOP raised lesion detectability and volumes across all modalities, with dMRI being consistently more sensitive than CBCT. T1W MRI showed lesions and bone loss similar to CBCT and was unaffected by BOP (<i>p</i> = 0.132) or PPD (<i>p</i> = 0.252). T2W MRI identified most lesions regardless of PPD and reflected high correlations with BOP (<i>p</i> &lt; 0.05), PPD (<i>p</i> &lt; 0.001) and PISA (<i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Reliability of dMRI for lesion identification and quantification was comparable to that of CBCT. The presence of T2W marrow oedema at sites with a CBCT-normal periodontal ligament space and no radiographically detectable bone loss may represent a promising imaging marker for early periodontal disease recognition and assessment of inflammatory burden.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 9","pages":"1382-1392"},"PeriodicalIF":8.3,"publicationDate":"2026-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70151","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148271571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Local Sodium Tanshinone IIA Sulfonate Attenuates Periodontal Bone Loss by Modulating Inflammatory, Immune and Osteoclastogenic Signalling","authors":"Rafael Scaf de Molon,&nbsp;Raquel Mantuaneli Scarel-Caminaga,&nbsp;François Isnaldo Dias Caldeira,&nbsp;Edilson Ervolino,&nbsp;Erica Dorigatti de Avila,&nbsp;Paula Aboud Barbugli,&nbsp;Gabriela Ezequiel Oliveira,&nbsp;Joao Pedro Franco-Moura,&nbsp;Leticia Helena Theodoro,&nbsp;Joni Augusto Cirelli,&nbsp;Sotirios Tetradis,&nbsp;Alpdogan Kantarci","doi":"10.1111/jcpe.70159","DOIUrl":"10.1111/jcpe.70159","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To investigate whether local administration of sodium tanshinone IIA sulfonate (STS) modulates periodontal inflammation, alveolar bone loss, immune response and bone remodelling–related signalling pathways in a ligature-induced murine model of periodontitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Sixty C57BL/6J male mice were randomly assigned to four groups: control group (C), periodontitis (P), low-dose (1 mg/kg) tanshinone (STS1) and high-dose (5 mg/kg) tanshinone treatment (STS5). Experimental periodontitis was induced by bilateral placement of ligatures around the first maxillary molars in the P, STS1 and STS5 groups. STS or vehicle was administered locally to the gingival tissues 2 days before disease induction and continued until the end of the experiment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>STS significantly attenuated periodontal bone loss, preserved bone microarchitecture, reduced inflammatory infiltrate and maintained collagen organisation. Mechanistically, STS suppressed RANKL-dependent osteoclastogenesis by down-regulating RANKL, CTSK, MMP-9, OSCAR and NFATc1 mRNA expression while restoring the RANKL/OPG balance, thereby limiting osteoclast differentiation and activity. In parallel, STS attenuated inflammatory signalling by inhibiting NF-κB pathway activation, as reflected by reduced NF-κB protein levels, stabilisation of its inhibitory regulator IκBα as well as suppression of IL-6, TNF-α and TGF-β gene expression, followed by a trend towards reduced IFN-γ gene levels. STS further modulated macrophage polarisation by reducing M1-like macrophages, as shown by decreased F4/80⁺CD80⁺ signal, while CD206 immunoreactivity increased. At the protein level, STS reduced TRAP, CTSK and NFATc1 expression while restoring RUNX2.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>STS effectively suppresses periodontal inflammation and alveolar bone destruction by modulating inflammatory signalling and attenuating M1-like macrophage polarisation, inhibiting osteoclastogenesis and partially restoring osteogenic pathways.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 9","pages":"1443-1458"},"PeriodicalIF":8.3,"publicationDate":"2026-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70159","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148379769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Orthodontic Tooth Movement on Intrabony Periodontal Defects After Guided Tissue Regeneration. Part II: The Evaluation of Clinical and Radiological Parameters in a Randomised Controlled Clinical Trial.","authors":"Pal Nagy, Andrea Dobos, Balint Nemes, Krisztian Kover, Peter Windisch","doi":"10.1111/jcpe.70183","DOIUrl":"https://doi.org/10.1111/jcpe.70183","url":null,"abstract":"<p><strong>Aim: </strong>To clinically and radiologically evaluate the healing capacity of intrabony periodontal defects treated with guided tissue regeneration (GTR) with or without the combination of orthodontic tooth movement (OTM).</p><p><strong>Materials and methods: </strong>Thirty-four individuals presenting with periodontal intrabony defects (IDs) and pathological tooth migration (PTM) were included in this randomised controlled clinical trial. Extended, coronally advanced flaps and GTR (collagen membrane and bovine bone mineral) were used to treat IDs. After surgery, patients were randomly allocated to either the test group (n = 17) with an early (1 week postoperatively) initiation of OTM or the control group (n = 17) without any tooth movement. Outcome variables comprised changes in clinical attachment level (CAL), probing pocket depth (PPD), gingival recession (GR), probing bone level and intrabony component (IC).</p><p><strong>Results: </strong>Both groups yielded statistically significant CAL gain (4.0 ± 2.0 mm in the test group and 4.4 ± 1.3 mm in the control group) and PPD reduction (3.9 ± 1.4 and 4.9 ± 1.7 mm, respectively) as well as IC reduction. However, only the control group showed a significant increase in GR and crestal bone loss from baseline to the endpoint. The change in IC was -4.3 ± 2.0 mm in the test group and -4.6 ± 1.8 mm in the control group, corresponding to 66% and 64.5% intrabony fill, respectively. All evaluated parameters showed comparable changes between the two groups, with no evidence of clinically meaningful differences.</p><p><strong>Conclusions: </strong>GTR combined with OTM resulted in similar clinical endpoint parameters after 9 months of healing compared with GTR alone. This clinical result confirms the histological findings (Part I article) that early initiation of OTM is feasible.</p>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":" ","pages":""},"PeriodicalIF":8.3,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148669923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}