Journal of Clinical Periodontology最新文献

{"title":"Efficacy of Adjunctive Agents in the Management of Biofilm-Induced Gingivitis: A Systematic Review and Meta-Analysis.","authors":"Elena Figuero, Crystal Marruganti, Nagore Ambrosio, Rossana Izzetti, Jorge Serrano, Filippo Graziani","doi":"10.1111/jcpe.70121","DOIUrl":"https://doi.org/10.1111/jcpe.70121","url":null,"abstract":"<p><strong>Aim: </strong>In systemically healthy humans with gingivitis, what is the efficacy of active agents compared to negative control/placebo when used adjunctively to mechanical biofilm control in terms of changes in gingivitis/bleeding indices and/or disease resolution in randomised controlled clinical trials (RCTs) with at least 3-months follow-up?</p><p><strong>Material and methods: </strong>Electronic searches, study selection, data extraction, risk of bias analysis, meta-analyses and certainty of the evidence were performed (GRADE).</p><p><strong>Results: </strong>Seventy-two RCTs were included (antiseptics n = 71; systemic intake n = 1). High heterogeneity was found in the definition of gingivitis. Antiseptic agents showed greater reductions in bleeding (%) than control groups at 3 months (n_comparison [n_c] = 19; weighted mean differences [WMD] = 10.66%; p < 0.001) and 6 months (n_c = 20; WMD = 10.79%; p < 0.001). Gingivitis resolution was rarely determined. Prevalence of local adverse effect (tooth-related and soft-tissue-related) varied from 0% to 13.1%. Systemic effects were scarcely evaluated.</p><p><strong>Conclusions: </strong>In adults with gingivitis, the adjunctive use of specific antiseptics determined higher reduction of gingival inflammation at 3 months (moderate evidence for stannous fluoride and low-to-very low for chlorhexidine, essential oils or cetylpyridinium chloride [CPC]) and 6 months (moderate for chlorhexidine, low for CPC and very low for essential oils) over placebo/negative controls. Adverse effects are neither frequently nor extensively reported. Gingivitis resolution is rarely reported and achieved.</p>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147874304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 6","pages":""},"PeriodicalIF":6.8,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148074753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 6","pages":""},"PeriodicalIF":6.8,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148077178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Periodontal Abscesses and Endodontic-Periodontal Lesions-A Systematic Review.","authors":"Henrik Dommisch,Daniela Hoedke,Marina Dourou,Elena Calciolari,David Herrera,Selena Toma","doi":"10.1111/jcpe.70135","DOIUrl":"https://doi.org/10.1111/jcpe.70135","url":null,"abstract":"AIMTo evaluate the management of periodontal abscesses and endodontic-periodontal lesions (EPLs).METHODSSeven focused questions addressed outcomes such as pocket depth (PD), bleeding on probing (BOP), tooth loss or ovoid elevation. The literature search covered three electronic databases and manual sources for intervention studies. Meta-analyses were not feasible.RESULTSFor periodontal abscesses and EPLs, a total of 987 and 545 articles were identified, and 17 and 44 were selected for full-text analysis, respectively. For periodontal abscesses, three randomised clinical trials (RCTs) and two prospective case series were included, and it was shown that combined approaches led to reductions in PD of 2-3 mm, BOP from 100% to 30%-44% and ovoid elevation from 92%-100% to 0%-11%. Abscess recurrence was found in 13.3%-23% within 15 months follow-up. For EPLs, nine RCTs, six prospective and two retrospective studies and one case series were included, and the overall synthesis showed that PD reductions ranged from 2.5 to 9.3 mm and tooth loss rate from 0% to 25% (3-120 months follow-up). Low to high risk of bias was evident.CONCLUSIONSPeriodontal abscesses can effectively be managed by initial drainage, followed by periodontal therapy, based on limited and weak evidence. For EPLs, endodontic and periodontal (non-surgical and surgical) interventions have been investigated, alone or in combination, but the heterogeneity of study designs and small sample sizes preclude strong conclusions.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"32 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147731417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Edentulism With Subsequent Biological Age: A Cohort Study","authors":"Yusuke Matsuyama,&nbsp;Sakura Kiuchi,&nbsp;Jun Aida","doi":"10.1111/jcpe.70106","DOIUrl":"10.1111/jcpe.70106","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Biological ageing is characterised by a gradual decline in physiological functions, resulting in increased susceptibility to diseases and mortality. We investigated the relationship between edentulism and biological ageing among adults in England.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data were drawn from participants in the English Longitudinal Study of Ageing who completed three consecutive biennial waves (waves 2–3–4 or 4–5–6), yielding 1889 individuals providing 2390 three-wave panel observations (mean age at baseline 68.1; men 47.7%). Edentulism was assessed in waves 3 and 5. Biological ageing was estimated using the Klemera and Doubal method, integrating multiple biomarkers assessed in waves 2, 4 and 6. Linear regression with clustered standard errors was employed to evaluate the association between edentulism and biological age in the subsequent wave (i.e., 2 years after the assessment of edentulism). Models were adjusted for pre-exposure confounders, including biological age, gender, socioeconomic status, existing health conditions and functional limitation assessed in the prior wave (i.e., 2 years before the assessment of edentulism).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Participants with edentulism exhibited a 5.8-year greater biological age than those with some remaining teeth in the subsequent waves. After adjusting for confounding variables, edentulism was associated with a 0.82-year greater biological age than those with some remaining teeth (95% confidence interval: 0.40–1.24) in the subsequent waves.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Edentulism was longitudinally associated with a greater biological age. Strategies that incorporate oral health promotion, particularly the prevention of tooth loss, may contribute to healthy ageing.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 5","pages":"752-759"},"PeriodicalIF":6.8,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70106","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 6","pages":"933-946"},"PeriodicalIF":6.8,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148080139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Untargeted Metabolomic and Lipidomic Profiles of Gingival Crevicular Fluid in the Context of Periodontitis","authors":"Caroline H. Henderzahs,&nbsp;Chiaki Yamada,&nbsp;Alexandr Morozov,&nbsp;Thelmalane Yalartai,&nbsp;Vanchit John,&nbsp;Hawra AlQallaf,&nbsp;Alexandru Movila","doi":"10.1111/jcpe.70105","DOIUrl":"10.1111/jcpe.70105","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim(s)</h3>\u0000 \u0000 <p>This cross-sectional clinical study aimed to explore the untargeted metabolomic and lipidomic profiles in gingival crevicular fluid (GCF) obtained from healthy individuals and patients with periodontitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>GCF was collected from 17 periodontally healthy and 19 periodontitis patients. For the unbiased characterisation of positively and negatively charged polar metabolite and lipid compounds, we employed hydrophilic interaction and reversed-phase liquid chromatography/mass spectrometry platforms, followed by a semisupervised deep learning-based approach for metabolomic peak curation and data analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 256 metabolites were identified with Metabolomics Standards Initiative (MSI) confidence Levels 1–3, including 198 elevated and 58 diminished compounds in periodontal lesions (<i>q</i> &lt; 0.05, |log₂-transformed Fold Change (FC)| &gt; 1). Periodontitis samples exhibited a significant positive accumulation of purine degradation and ceramide metabolites, along with a negative regulation of oxy fatty acids metabolism. Additionally, we observed a significant increase in established periodontitis biomarkers, including N-acetylneuraminic acid, citrulline and 2-pyrrolidineacetic acid. The study also characterised distinct differences in bacterial and fungal metabolite profiles between the healthy and diseased samples.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings suggest that untargeted metabolomic screening of GCF may significantly improve our understanding of biochemical changes between healthy tissue and periodontitis. This knowledge is pivotal for the development of a precision paradigm in periodontitis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 5","pages":"774-783"},"PeriodicalIF":6.8,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Tobacco Smoking on Tooth Loss: A Systematic Review and Meta-Analysis","authors":"Ziqi Chen,&nbsp;Gagandeep Kaur,&nbsp;Nadia Kaunein,&nbsp;Claireta Handoko,&nbsp;Marco A. Peres,&nbsp;Melissa Russell,&nbsp;Ankur Singh","doi":"10.1111/jcpe.70110","DOIUrl":"10.1111/jcpe.70110","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This systematic review aims to examine the causal effect of tobacco smoking on tooth loss. Further, the impact of different frequencies, intensities and lifetime exposures to tobacco smoking on tooth loss and whether the relationship differs by socioeconomic status (SES) are reviewed in the sub-group analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>An electronic search was conducted in Embase (Ovid), Ovid MEDLINE and Web of Science for studies published up to May 2025. No limits on publication dates were applied. This review included case–control and cohort studies that reported the effect of tobacco smoking on tooth loss. Risk of Bias of included studies was assessed by ROBINS-E assessment tool.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 30 studies were included in this systematic review. The meta-analysis from five studies indicated that current smokers have 1.41 times higher risk of tooth loss (RR 1.41, 95% CI: 1.24–1.60) than nonsmokers (sample size range: 273–34,975, <i>n</i> = 5). Past smoking also increases the risk of having tooth loss (RR 1.21, 95% CI: 1.07–1.37) (sample size range: 547–34,975, <i>n</i> = 2). None of the studies examined the effect of smoking on tooth loss by different SES.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This systematic review highlights the importance and urgency of quitting smoking for better oral health.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 5","pages":"784-805"},"PeriodicalIF":6.8,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70110","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147465373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 6","pages":"933-946"},"PeriodicalIF":6.8,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148080138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral-Rinse-Sourced Microbiota in Oral Health and Diseases in a Representative US Adult Population: Implications for Diagnostics","authors":"Yu Xie,&nbsp;Alejandro Artacho,&nbsp;Xiaoyu Yu,&nbsp;Mengning Bi,&nbsp;Hairui Li,&nbsp;Yuan Li,&nbsp;Andrea Roccuzzo,&nbsp;Alex Mira,&nbsp;Bob T. Rosier,&nbsp;Maurizio S. Tonetti","doi":"10.1111/jcpe.70101","DOIUrl":"10.1111/jcpe.70101","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To investigate the associations between oral-rinse microbiota and distinct oral conditions, and further evaluate its potential ability to distinguish periodontitis severity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Oral-rinse-sourced microbiota with 16S ribosomal RNA sequencing from 3770 adults in US National Health and Nutrition Examination Survey 2009–2012 were analysed across oral health, caries, periodontitis, co-existing caries and periodontitis and edentulism. Diagnostic potential of the oral-rinse microbiota for periodontitis severity was evaluated using multi-class random forest (RF) model with internal validation and external validation in an independent cohort (<i>n</i> = 392).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Oral condition accounted for substantial variance in oral-rinse microbiota, revealing disease or tooth loss–associated shifts. Increasing acidogenic/aciduric taxa (<i>Veillonella</i>, <i>Lactobacillus</i>, <i>Atopobium</i>) or periodontitis-associated taxa (<i>Filifactor</i>, <i>Treponema</i>, <i>Tannerella</i>) were identified in caries-only or periodontitis-only groups, respectively, while the co-existing disease group showed overlapping shifts. Taxa shifted dose-dependently with increasing periodontitis severity. The RF model achieved moderate performance in identifying severe periodontitis, with the area under the receiver operating characteristic curve (AUROC) of 0.81 (0.75–0.87) internally and 0.83 (0.77–0.88) externally. Key contributing taxa aligned with established periodontitis-associated genera, supporting model interpretability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Based on our results, oral-rinse microbiota captures disease-specific signatures across oral conditions, supporting its potential as a non-invasive tool to monitor oral microbial ecology and assess periodontitis severity at the population level.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 5","pages":"760-773"},"PeriodicalIF":6.8,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70101","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145968458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}