Journal of Clinical Periodontology最新文献

{"title":"Periodontal Care Is Associated With a Lower Risk of Dialysis Initiation in Middle-Aged Patients With Type 2 Diabetes Mellitus: A 6-Year Follow-Up Cohort Study Based on a Nationwide Healthcare Database","authors":"Taro Kusama,&nbsp;Yudai Tamada,&nbsp;Ken Osaka,&nbsp;Kenji Takeuch","doi":"10.1111/jcpe.14105","DOIUrl":"10.1111/jcpe.14105","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the association between dental attendance with periodontal care and the risk of dialysis initiation in patients with type 2 diabetes mellitus (T2D).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective cohort study used data from the Japan Medical Data Center (JMDC) claims database (January 2015 to August 2022). Patients with T2D, aged 40–74, were included. Dental attendance with periodontal care and initiation of dialysis were used as the exposure and outcome variables, respectively. We fitted the Cox proportional hazards model, including potential confounders, to estimate hazard ratios (HRs) and 95% confidence intervals (95%CIs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 99,273 participants (mean age = 54.4 years [SD = 7.8], male = 71.9%), the incidence rate of dialysis initiation was 0.92 per 1000 person-years. After adjusting for all covariates, those with periodontal care (HR = 0.68 [95%CI = 0.51–0.91] for ≥ 1 time/year and HR = 0.56 [95%CI = 0.41–0.77] for ≥ 1 time/6 months) had a significantly lower risk of dialysis initiation compared to those without dental attendance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Periodontal disease care in patients with T2D is associated with a reduced risk of dialysis initiation by 32%–44%. This suggests that integrating periodontal care into diabetes management may help prevent the progression of diabetic nephropathy and improve patient outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 5","pages":"717-726"},"PeriodicalIF":5.8,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Retrospective Study of Stabilizing Bridges in Patients With Stages III and IV Periodontitis: Up to 35 Years of Clinical Audit","authors":"Øystein Fardal,&nbsp;Jostein Grytten","doi":"10.1111/jcpe.14116","DOIUrl":"10.1111/jcpe.14116","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background/Aim</h3>\u0000 \u0000 <p>Studies on large cross-arch bridges in patients with severe periodontitis show that such bridges can stabilize the periodontal condition. However, it is not known if these bridges will reduce long-term tooth loss and what factors are important for their long-term survival. The aim of the study was to study all patients with Stages III/IV periodontitis who received cross-arch bridges for up 35 years in a private practice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>All patients referred for periodontal treatment from 1986 who received cross-arch bridges with observation period of minimum 7 years were assessed. All dropouts were accounted for.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Ninety-eight patients (1.7% of the patient population) with 111 bridges were observed (57 females and 37 males). Age at bridge construction was 55.4 years (SD = 7.1, range 39–79). Failure rate was 14.4% at 16.1 years (SD = 4.0 range 10–22). Reasons for failure were poor oral hygiene (<i>p</i> = 0.0093) and complications such as caries, endontics, porcelain fractures and gingival retractions during maintenance therapy (<i>p</i> = 0.0059). Fewer abutment teeth were lost from the bridges than teeth from the same and opposing arches (8.8% vs. 34.4% and 25.4%) (<i>p</i> &lt; 0.0001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Cross-arch bridges constructed for patients with Stages III and IV periodontitis were successful in terms of longevity, low failure rates, tooth preservation and patient satisfaction.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 6","pages":"826-835"},"PeriodicalIF":5.8,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14116","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontal Probing Depth Trajectory in 10 Years of Follow-Up as Associated With Tooth Loss","authors":"Peter Meisel,&nbsp;Henry Völzke,&nbsp;Thomas Kocher","doi":"10.1111/jcpe.14117","DOIUrl":"10.1111/jcpe.14117","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To elucidate whether ranked probing depth (PD) data translate into ranked PD outcomes after 10 years of follow-up and the associated tooth loss.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>From the Study of Health in Pomerania (SHIP-START), all participants were retrospectively included with complete PD measurements in both baseline and 10-year follow-up, comprising 1887 participants. The trajectory of percentile-based quintiles of mean PD measurements was followed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Quintiles of mean PD at baseline were, in a dose dependent manner, associated with the number of teeth at baseline, number of teeth after 10 years and involved risk of tooth loss. The trajectory of membership to individual PD quintiles indicated that the majority of participants remained in or near their baseline quintile after reaching the 10-year end analysis. Periodontal risk factors assessed at baseline continued to affect PD outcomes at follow-up. Two categories of tooth loss were identified: 1–2 teeth lost versus ≥ 3 teeth and differentiated by baseline PD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>PD severity ranked within this population translates, in a dose-dependent manner, to follow-up tooth loss even after many years. This underlines the prospective importance of pocket probing in the dental practice. Ranked PD offers a simple measure to identify patients at high risk of tooth loss.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 6","pages":"859-867"},"PeriodicalIF":5.8,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14117","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persisting Chronic Periodontal Disease as a Risk Factor for Cardiovascular Disease: A Nationwide Population-Based Cohort Study","authors":"Jung-Hyun Park,&nbsp;Gwang Hyun Leem,&nbsp;Jin-Woo Kim,&nbsp;Tae-Jin Song","doi":"10.1111/jcpe.14107","DOIUrl":"10.1111/jcpe.14107","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>Epidemiological studies have consistently established a positive association between periodontal disease (PD) and cardiovascular disease (CVD). However, large-scale investigations exploring the impact of changes in PD status on CVD risk are scarce. This study aimed to investigate the association between the dynamics in PD and the risk of incident CVD in a nationally representative population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Utilising data from the Korean National Health Insurance Service, a cohort of 1,242,570 participants who underwent oral health exams in 2003 and a follow-up exam in 2005–2006 was analysed. Participants were categorized into groups based on changes in PD status: absent, improvement, onset and persistent. Cox proportional hazard models were employed to assess the multivariate-adjusted hazard ratios (HRs) for composite CVD outcomes, including death, myocardial infarction and stroke.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Over a mean follow-up of 14.4 years, 79,810 (6.4%) cases of composite CVD occurred, including 14,296 (1.2%) myocardial infarctions, 3247 (0.3%) hemorrhagic strokes and 8900 (0.7%) ischemic strokes. Individuals with persistent PD showed the highest risk of CVD (HR: 1.04, 95% CI: 1.03–1.06, <i>p</i> &lt; 0.001). In the pairwise comparisons, the PD improvement group exhibited a lower composite CVD risk than the PD persistent group (HR: 0.97, 95% CI: 0.96–0.99, <i>p</i> = 0.010); similarly, the PD onset group showed a lower risk than the PD persistent group (HR: 0.94, 95% CI: 0.93–0.96, <i>p</i> &lt; 0.001). This pattern was consistent in the risk of death, with both the PD improvement and PD onset groups showing a lower risk of death than the PD persistent group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study suggests the dynamic nature of PD as a potential modifiable risk factor for CVD. Individuals with chronically persistent PD showed an elevated incidence risk of CVD, emphasizing the importance of managing PD in preventive strategies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 3","pages":"375-386"},"PeriodicalIF":5.8,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142887906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Accuracy of Novel Protein Biomarkers in Saliva to Detect Periodontitis Using Untargeted ‘SWATH’ Mass Spectrometry","authors":"T. Blanco-Pintos,&nbsp;A. Regueira-Iglesias,&nbsp;M. Relvas,&nbsp;M. Alonso-Sampedro,&nbsp;S. B. Bravo,&nbsp;C. Balsa-Castro,&nbsp;I. Tomás","doi":"10.1111/jcpe.14103","DOIUrl":"10.1111/jcpe.14103","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To discover new salivary biomarkers to diagnose periodontitis and evaluate the impact of age and smoking on predictive capacity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Saliva samples were collected from 44 healthy periodontal individuals and 41 with periodontitis. Samples were analysed by sequential window acquisition of all theoretical mass spectra (SWATH-MS), and proteins were identified by employing the UniProt database. The diagnostic capacity of the molecules was determined with generalized additive models. The models obtained were single-protein unadjusted and adjusted for age and smoking status, besides two-protein combinations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Eight single salivary proteins had a bias-corrected accuracy (bc-ACC) of 78.8%–86.8% (bc-sensitivity/bc-specificity of 62.5%–86.9%/60.9%–98.1%) to diagnose periodontitis. Predictive capacity increased more by adjusting for age (bc-ACC: 94.1%–98.2%; bc-sensitivity/bc-specificity: 90.2%–98.6%/93.6%–97.2%) than smoking (bc-ACC: 83.9%–90.4%; bc-sensitivity/bc-specificity: 73.6%–89.9%/76.2%–96.4%). These proteins were keratin, type II cytoskeletal 1, protein S100-A8, β-2-microglobulin, neutrophil defensin 1, lysozyme C, ubiquitin-60S ribosomal protein L40, isoform 2 of tropomyosin α-3 chain and resistin. Two dual combinations showed bc-sensitivity/bc-specificity of &gt; 90%: β-2-microglobulin with profilin-1, and lysozyme C with zymogen granule protein 16 homologue B.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>New salivary biomarkers show good or excellent ability to diagnose periodontitis. Age has a more significant influence on the accuracy of the single biomarkers than smoking, with results comparable to two-protein combinations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 2","pages":"199-214"},"PeriodicalIF":5.8,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14103","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142887870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Comparative Evaluation of a Reinstructed GPT-4o Model Specialized in Periodontology","authors":"Francesco Fanelli,&nbsp;Muhammad Saleh,&nbsp;Pasquale Santamaria,&nbsp;Khrystyna Zhurakivska,&nbsp;Luigi Nibali,&nbsp;Giuseppe Troiano","doi":"10.1111/jcpe.14101","DOIUrl":"10.1111/jcpe.14101","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Artificial intelligence (AI) has the potential to enhance healthcare practices, including periodontology, by improving diagnostics, treatment planning and patient care. This study introduces ‘PerioGPT’, a specialized AI model designed to provide up-to-date periodontal knowledge using GPT-4o and a novel retrieval-augmented generation (RAG) system.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>PerioGPT was evaluated in two phases. First, its performance was compared against those of five other chatbots using 50 periodontal questions from specialists, followed by a validation with 71 questions from the 2023–2024 ‘In-Service Examination’ of the American Academy of Periodontology (AAP). The second phase focused on assessing PerioGPT's generative capacity, specifically its ability to create complex and accurate periodontal questions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>PerioGPT outperformed other chatbots, achieving a higher accuracy rate (81.16%) and generating more complex and precise questions with a mean complexity score of 3.81 ± 0.965 and an accuracy score of 4.35 ± 0.898. These results demonstrate PerioGPT's potential as a leading tool for creating reliable clinical queries in periodontology.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study underscores the transformative potential of AI in periodontology, illustrating that specialized models can offer significant advantages over general language models for both educational and clinical applications. The findings highlight that tailoring AI technologies to specific medical fields may improve performance and relevance.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 5","pages":"707-716"},"PeriodicalIF":5.8,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14101","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142887908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cathepsin B Modulates Alzheimer's Disease Pathology Through SAPK/JNK Signals Following Administration of Porphyromonas gingivalis-Derived Outer Membrane Vesicles","authors":"Muzhou Jiang,&nbsp;Ziming Ge,&nbsp;Shoucheng Yin,&nbsp;Yanqing Liu,&nbsp;Hanyu Gao,&nbsp;Lijie Lu,&nbsp;Hongyan Wang,&nbsp;Chen Li,&nbsp;Junjun Ni,&nbsp;Yaping Pan,&nbsp;Li Lin","doi":"10.1111/jcpe.14109","DOIUrl":"10.1111/jcpe.14109","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>\u0000 \u0000 <i>Porphyromonas gingivalis</i>\u0000 , a consensus periodontal pathogen, is thought to be involved in Alzheimer's disease (AD) progression, and \u0000 <i>P. gingivalis</i>\u0000 -derived outer membrane vesicles (<i>Pg</i>OMVs) are a key toxic factor in inducing AD pathology. This study aimed to clarify the regulatory mechanism underlying the <i>Pg</i>OMV-induced AD-like phenotype.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>We intraperitoneally injected <i>Pg</i>OMVs into the periphery of wild-type and <i>CatB</i> knockout mice for 4 or 8 weeks to assess the effect of CatB on <i>Pg</i>OMV-induced AD pathology. Mice were evaluated for cognitive change, tau phosphorylation, microglial activation, neuroinflammation and synapse loss. Microglial and primary neuron culture were prepared to verify the in vivo results.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>CatB deficiency significantly alleviated <i>Pg</i>OMV-induced cognitive dysfunction, microglia-mediated neuroinflammation, tau hyperphosphorylation and synapse loss. Subsequent transcriptomic analysis, immunofluorescence and immunoblotting suggested that CatB modulates microglia-mediated neuroinflammation through stress-activated protein kinases (SAPK)/Jun amino-terminal kinases (JNK) signals after administration of <i>Pg</i>OMVs, which in turn regulates neuronal tau phosphorylation and synapse loss in a SAPK/JNK-dependent manner.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our study unveils a previously unknown role of CatB in regulating <i>Pg</i>OMV-induced AD pathology.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 3","pages":"434-456"},"PeriodicalIF":5.8,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142887902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone Regeneration After Sinus Floor Elevation in an Intact Sinus or a Sinus With Prior Large Membrane Perforation: A Preclinical Study Using a Rabbit Sinus Model","authors":"Sunmin Lee,&nbsp;Jong-Hyuk Chung,&nbsp;Daniel S. Thoma,&nbsp;Ronald E. Jung,&nbsp;Ui-Won Jung,&nbsp;Seung-Yun Shin,&nbsp;Hyun-Chang Lim","doi":"10.1111/jcpe.14108","DOIUrl":"10.1111/jcpe.14108","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To determine bone regeneration following sinus floor elevation (SFE) at sites with or without prior sinus membrane perforation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>The sinus membranes in the maxillary sinuses of 12 rabbits were intentionally perforated (≥ 5 mm) on one side, followed by application of a collagen matrix. SFE was performed on both sinuses after 8 weeks of healing, presenting two groups: SFE with a previous large sinus membrane perforation (group SFE_Perf), and in an intact sinus (group SFE). The animals were euthanized at 2 and 4 weeks after SFE. Micro-computed tomographic and histomorphometric analyses were performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The amount of newly formed bone within the augmented area did not differ significantly between the two groups at 2 weeks and 4 weeks (4.7 ± 1.0 mm² vs. 5.3 ± 1.4 mm² and 9.2 ± 1.7 mm² vs. 10.8 ± 2.2 mm², respectively, mean ± SD; <i>p</i> &gt; 0.05). However, the amount of newly formed bone near the middle of the sinus membranes was significantly greater in group SFE than in group SFE_Perf (<i>p</i> &lt; 0.05). There was no significant difference in the augmented volume. Fewer subepithelial glands and denser collagen fibres within the sinus membranes were observed in group SFE_Perf than in group SFE.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>A large perforation of the sinus membrane followed by an 8-week healing period did not jeopardize new bone formation following SFE.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 3","pages":"421-433"},"PeriodicalIF":5.8,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Effect of Smoking and Cessation on Tooth Loss","authors":"Sebastian-Edgar Baumeister,&nbsp;Stefan Listl,&nbsp;Birte Holtfreter,&nbsp;Gustavo G. Nascimento,&nbsp;Fabio R. M. Leite","doi":"10.1111/jcpe.14106","DOIUrl":"10.1111/jcpe.14106","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To estimate the causal effects of smoking and cessation on tooth loss using instrumental variable (IV) analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Data from the Behavioural Risk Factor Surveillance System (BRFSS), conducted from 1995 to 2006, 2008, 2010, and 2012 in 50 U.S. states and Washington DC, were merged with cigarette pack prices and smoking ban data from the CDC ‘Tax Burden on Tobacco’ and ‘State Tobacco Activities Tracking and Evaluation’ (STATE) System. Prices and bans served as IVs for ever smoking and cessation in a control function IV model for self-reported edentulism and loss of 6+ teeth. IV models were adjusted for age, sex, race/ethnicity, educational attainment, type 2 diabetes, state unemployment rates, state health expenditures, and state fixed effects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Ever smoking cigarettes increased the risk of edentulism by 2.6% (95% CI: 2.3%–2.8%) and the risk of loss of 6+ teeth by 10.7% (95% CI: 10.0%–11.3%). Smoking cessation reduced risks of edentulism and loss of 6+ teeth by 7.6% (95% CI: −7.8% to −742%) and 13.5% (95% CI: −13.7% to 13.3%), respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study provides robust evidence that smoking increases tooth loss risk, while cessation significantly reduces it, emphasizing the oral health benefits of tobacco control policies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 4","pages":"539-546"},"PeriodicalIF":5.8,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14106","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Single-Cell Genomics to Animal Models of Periodontitis and Peri-Implantitis","authors":"Akira Hasuike,&nbsp;Quinn T. Easter,&nbsp;Daniel Clark,&nbsp;Kevin M. Byrd","doi":"10.1111/jcpe.14093","DOIUrl":"10.1111/jcpe.14093","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This narrative review aims to synthesize current knowledge on integrating single-cell genomics technologies with animal models of periodontitis and peri-implantitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Review</h3>\u0000 \u0000 <p>Single-cell RNA sequencing (scRNAseq) reveals cellular heterogeneity and specific cell roles in periodontitis and peri-implantitis, overcoming the limitations of bulk RNA sequencing. Under controlled conditions and genetic manipulation, animal models facilitate studying disease progression, gene functions and systemic disease links, aiding targeted therapy development. Knockout models have started to elucidate the impact of genetic mutations on periodontal disease and host responses. scRNAseq in animal models has been used to examine connections between periodontitis and systemic diseases, revealing altered immune environments and cellular interactions. Emerging studies are now applying these methods to animal models of peri-implantitis. Integrating these datasets into single-cell and spatially resolved atlases will enable future meta-analyses, providing deeper insights into disease mechanisms considering factors such as sex, strain, and age.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Integrating scRNAseq with animal models advances the understanding of periodontitis and peri-implantitis pathogenesis and precision therapies. The combined use of single-cell and spatial genomics and scRNAseq will further enhance data insights significantly for drug discovery and preclinical testing, making these technologies pivotal in validating animal models and translating findings into clinical practice.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 2","pages":"268-279"},"PeriodicalIF":5.8,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}