Journal of Clinical Periodontology最新文献

{"title":"Evaluating the Performance and Implementation of the 2018 Classification of Periodontal Diseases: A Systematic Review and Survey","authors":"Nicola X. West,&nbsp;Alexander Gormley,&nbsp;Alexander J. Pollard,&nbsp;Rossana Izzetti,&nbsp;Crystal Marruganti,&nbsp;Filippo Graziani","doi":"10.1111/jcpe.14170","DOIUrl":"10.1111/jcpe.14170","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate the performance and implementation of the 2018 Classification of Periodontal Diseases for periodontitis through systematic review and survey methodology.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A two-part systematic review was conducted. Part 1 aimed, with descriptive statistics, to evaluate performance metrics of the 2018 Classification, including diagnostic accuracy, prognostic performance and examiner reliability. Part 2 used thematic analysis to elucidate facilitators and barriers to the implementation of the classification. A survey collected evidence of barriers, facilitators and local implementation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Part 1 of this review included 14 individual studies of moderate risk of bias. Eight studies examined diagnostic accuracy, three studies examined prognostic efficacy and three studies examined inter-/intra-rater reliability. Part 2 included 33 individual studies with data considered at high risk of bias. The survey returned 1113 responses. The thematic analysis in Part 2 led to seven findings, five related to facilitators and two concerning barriers to the implementation. Survey results showed that 78% of respondents currently use the classification, but the most common concerns relate to its complexity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The 2018 Classification performs well as a classification in comparison with previous classifications. Specific identified barriers have potentially limited the comprehensive uptake of the classification.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 S29","pages":"34-57"},"PeriodicalIF":5.8,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14170","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143920069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-Emptive Analgesia for Periodontal and Implant-Related Surgery: A Systematic Review and Meta-Analysis","authors":"Christos Gousias,&nbsp;Zainab Alsuwaiyan,&nbsp;Alissa Fial,&nbsp;Shengtong Han,&nbsp;Dimitris N. Tatakis,&nbsp;Vrisiis Kofina","doi":"10.1111/jcpe.14157","DOIUrl":"10.1111/jcpe.14157","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This systematic review aimed to answer the question: In patients undergoing periodontal and peri-implant surgery, gingival augmentation, implant site development or placement, are pre-emptive analgesics effective in controlling post-operative pain compared with patients not receiving pre-emptive medications?</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>After comprehensive electronic and manual literature searches, randomised placebo-controlled clinical trials on adults undergoing the aforementioned surgeries were included. A meta-analysis was performed comparing pain (standardised mean difference) between pre-emptive medication and placebo at post-operative hours 1, 3, 6, 8, 24 and 72.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Two reviewers screened 1995 titles, included 18 studies in the systematic review (open flap debridement, osseous, mucogingival, unspecified periodontal surgery, implant placement; 1008 patients) and 7 studies in the meta-analysis. Non-steroidal anti-inflammatory drugs, acetaminophen and corticosteroids were prescribed 8 h to immediately pre-operatively and post-operatively until 12 h after the first dose. A clinically significant pain reduction peaked at 3 h (−0.81 [95% CI: −1.03, −0.58]; 9 study arms, <i>n</i> = 165 drug vs. <i>n</i> = 96 placebo patients) and was significant until 8 h (−0.54 [95% CI: −0.79, −0.28]; 7 study arms, <i>n</i> = 126 drug vs. <i>n</i> = 96 placebo patients), with moderate certainty of evidence (GRADE assessment).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Pre-emptive analgesia can reduce pain for up to 8 h following periodontal and implant placement surgery.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 8","pages":"1167-1195"},"PeriodicalIF":5.8,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143920070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Capitalising on Tax Variation to Estimate the Effect of Alcohol Consumption on Edentulism","authors":"Sebastian-Edgar Baumeister,&nbsp;Birte Holtfreter,&nbsp;Thomas Kocher,&nbsp;Gustavo G. Nascimento","doi":"10.1111/jcpe.14176","DOIUrl":"10.1111/jcpe.14176","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To estimate alcohol consumption's effect on edentulism using state alcohol taxes as an instrumental variable (IV).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Analysis of 514,357 U.S. Behavioural Risk Factor Surveillance System participants (2003–2006, 2008, 2010, 2012) linked to state alcohol taxes. We used IV regression modelling to assess the relationship between alcohol consumption and edentulism, plus potential mediators (body mass index, dental visits) and a positive control (coronary heart disease). Robustness to imperfect exogeneity was evaluated through sensitivity analyses and falsification testing using IV analysis on individuals under the age of 16 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A 1.1-drink increment per day was associated with a 12% higher risk of edentulism (95% confidence interval: 9%–16%). Alcohol consumption was positively associated with body mass index, dental visits and coronary heart disease. No significant effect on edentulism was observed in the negative control population (individuals aged &lt; 16 years).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The findings of this quasi-experimental study suggest that alcohol consumption increases the risk of edentulism.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 8","pages":"1108-1114"},"PeriodicalIF":5.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14176","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143914930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consensus Report of the 20th European Workshop on Periodontology: Contemporary and Emerging Technologies in Periodontal Diagnosis","authors":"David Herrera,&nbsp;Maurizio S. Tonetti,&nbsp;Iain Chapple,&nbsp;Moritz Kebschull,&nbsp;Panos N. Papapanou,&nbsp;Anton Sculean,&nbsp;Loreto Abusleme,&nbsp;Mario Aimetti,&nbsp;Georgios Belibasakis,&nbsp;Juan Blanco,&nbsp;Nagihan Bostanci,&nbsp;Philippe Bouchard,&nbsp;Nurcan Buduneli,&nbsp;Elena Calciolari,&nbsp;Maria Clotilde Carra,&nbsp;Tali Chackartchi,&nbsp;Bettina Dannewitz,&nbsp;Monique Danser,&nbsp;Ke Deng,&nbsp;Jan Derks,&nbsp;Thomas Dietrich,&nbsp;Nicola Discepoli,&nbsp;Kimon Divaris,&nbsp;Henrik Dommisch,&nbsp;Nikos Donos,&nbsp;Nicolás Dutzan,&nbsp;Peter Eickholz,&nbsp;Bahar Eren Kuru,&nbsp;Ricardo Faria Almeida,&nbsp;Roberto Farina,&nbsp;Balazs Feher,&nbsp;Elena Figuero,&nbsp;William Giannobile,&nbsp;Marjolaine Gosset,&nbsp;Filippo Graziani,&nbsp;Ulvi K. Gursoy,&nbsp;Daniel Hagenfeld,&nbsp;Karin Jepsen,&nbsp;Sören Jepsen,&nbsp;Purnima Kumar,&nbsp;Marja L. Laine,&nbsp;France Lambert,&nbsp;Niklaus P. Lang,&nbsp;Yuan Li,&nbsp;Bruno Loos,&nbsp;Phoebus Madianos,&nbsp;Paula Matesanz,&nbsp;Brian Mealey,&nbsp;Ana Molina,&nbsp;Eduardo Montero,&nbsp;Luigi Nibali,&nbsp;Philip Preshaw,&nbsp;Mia Rakic,&nbsp;Christoph Ramseier,&nbsp;Giovanni Salvi,&nbsp;Nerea Sánchez,&nbsp;Ignacio Sanz-Sánchez,&nbsp;Lior Shapira,&nbsp;Andreas Stavropoulos,&nbsp;Faleh Tamimi,&nbsp;Wim Teughels,&nbsp;Cristiano Tomasi,&nbsp;Leonardo Trombelli,&nbsp;Spyros Vassilopoulos,&nbsp;Anders Verket,&nbsp;Nicola West,&nbsp;Peter Windisch,&nbsp;Mariano Sanz","doi":"10.1111/jcpe.14152","DOIUrl":"10.1111/jcpe.14152","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>This Consensus Workshop dealt with diagnostic methodologies in the context of surveillance, screening, assessment of stage and grade, prognosis, monitoring and prediction of periodontal status. Several elements provided the impetus for the workshop, including the limited quality of available research on diagnostic tests, the rapid development of new technologies, the implementation of the 2018 classification and the declarations of the World Health Organisation on diagnosis and oral health.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To update and evaluate the evidence on diagnostic methods, considering recent advances in knowledge and the implementation of the 2018 classification.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The European Workshop Committee of the European Federation of Periodontology guided the development of a consensus report after commissioning eight systematic reviews within three working groups. The reviews were discussed during the in-person consensus meeting involving 70 participants from 21 different countries.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Working Group 1 discussed innovations in traditional diagnostic approaches, justified manual probing as the reference standard and assessed the value of image-based methods. Working Group 2 analysed diagnostic tests based on microbial and host biomarkers and genetic diagnostic tests. Working Group 3 covered emerging technologies to be used within dental and non-dental clinical settings, focusing principally on the impact of questionnaire-based assessments and artificial intelligence systems (AIS) in interpreting different data modalities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Although manual periodontal probing is firmly established as the reference standard, additional approaches based on imaging, biomarkers, host genetics, questionnaires and the development of emerging applied data science methods (e.g., AIS) are increasingly integrated in periodontal diagnostics.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 S29","pages":"4-33"},"PeriodicalIF":5.8,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14152","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143905813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of Clinical Parameters in Predicting/Diagnosing Peri-Implant Bone Loss","authors":"Mario Romandini,&nbsp;Cristina Lima,&nbsp;Miguel Moreno,&nbsp;Mariano Sanz","doi":"10.1111/jcpe.14095","DOIUrl":"10.1111/jcpe.14095","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Aim&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To determine whether clinical parameters can serve as (i) predictive tools (before occurrence) and (ii) diagnostic tools (after occurrence) of peri-implant bone loss.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Materials and Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A representative cohort of 72 patients with 298 implants was evaluated at baseline and after a mean follow-up period of 3.9 years. Peri-implant bone loss &gt; 1 mm between the two examinations represented the reference standard. The accuracy of the following clinical parameters in predicting (at baseline) or diagnosing (at follow-up) peri-implant bone loss was assessed: presence of bleeding (BoP) or suppuration (SoP) on probing, visual signs of redness or swelling, BoP extent (number of sites with BoP) and severity (modified Bleeding Index—mBI), probing pocket depth (PPD) at various cut-offs, peri-implant soft-tissue dehiscence (PISTD) and changes in PPD/PISTD over time. Predictive/diagnostic performance was evaluated using mixed model logistic regression analyses and reporting sensitivity, specificity, positive/negative predictive values and area under the curve (AUC) values.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Bone loss &gt; 1 mm was observed in 9.4% of implants and was frequently preceded by BoP (sensitivity = 96.4%; specificity = 7.4%). At follow-up, bone loss was always associated with the concomitant presence of BoP (sensitivity = 100.0%; specificity = 14.4%).&lt;/p&gt;\u0000 \u0000 &lt;p&gt;In predicting the future occurrence of peri-implant bone loss, high sensitivity (94.4%) was also noted for visual redness at baseline, although its specificity was low (25.9%). Conversely, high specificity but low sensitivity was observed for BoP at 6 sites (sensitivity = 25.0%; specificity = 88.1%) and SoP (sensitivity = 14.3%; specificity = 91.5%).&lt;/p&gt;\u0000 \u0000 &lt;p&gt;For diagnosing recent peri-implant bone loss, high specificity was noted for SoP (100.0%), profuse bleeding (91.9%), BoP at 6 sites (87.0%), PPD ≥ 6 mm (81.9%), changes in PPD (95.9%) and changes in PISTD (91.5%). However, all these parameters showed limited sensitivity. The best diagnostic accuracy was achieved using a combined criterion of site-specific PPD or PISTD increases &gt; 1 mm over time (sensitivity = 82.1%; specificity = 70.0%; AUC = 0.76).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Clinical signs considered indicative of peri-implant mucositis (presence of BoP, visual redness) usually precede peri-implant bone loss. Implants with a recent history of bone loss always present with co","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 8","pages":"1070-1081"},"PeriodicalIF":5.8,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14095","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143905739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Multi-Centre Randomised Controlled Trial Comparing dPTFE Membrane to Collagen Membrane in Lateral Bone Augmentation at Single Sites in the Anterior Maxilla: 1-Year Results","authors":"Matthijs Hindryckx,&nbsp;Thomas De Bruyckere,&nbsp;Stefanie De Buyser,&nbsp;Lorenz Seyssens,&nbsp;Retis Shtino,&nbsp;Faris Younes,&nbsp;Jan Cosyn","doi":"10.1111/jcpe.14174","DOIUrl":"10.1111/jcpe.14174","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To compare a dense polytetrafluoroethylene (dPTFE) membrane with a collagen membrane in guided bone regeneration for lateral bone augmentation at single sites in the anterior maxilla in terms of alveolar width, height, complications, need for additional therapy and implant outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Patients with a class 4 defect at a single site in the anterior maxilla (15–25) were recruited at five centres. Following flap elevation and conditioning of the recipient site, they were randomly allocated to the dPTFE membrane group or the collagen membrane group. Nine months following bone augmentation, re-entry was performed and implants were placed. Alveolar dimensions were assessed on superimposed cone-beam computed tomography images taken prior to surgery, immediately post operation and at 9 months. Implant outcomes were registered 1 year after bone augmentation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Thirty-six patients were randomised (dPTFE membrane group: 8 females, 10 males, mean age 39; collagen membrane group: 14 females, 4 males, mean age 51) and all complied until the 1-year follow-up. At 9 months, the estimated marginal mean alveolar width was not significantly different between the groups (estimated marginal mean difference at 3 mm below the crest: 0.65 mm; 95% CI: −0.82 to 2.12; <i>p</i> = 0.381). Infection occurred in 6/18 patients treated with a dPTFE membrane and in 0/18 patients treated with a collagen membrane (<i>p</i> = 0.019). Infection occurred in every centre and had a negative impact on the alveolar width at 9 months, despite taking anti-infective measures in every patient and additional bone augmentation in two patients. Implants could be installed in a prosthetically driven position, integrated uneventfully and yielded minimal marginal bone loss.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>dPTFE membrane and collagen membrane are both effective in lateral bone augmentation. However, dPTFE membrane is more prone to infection than collagen membrane, thereby increasing the need for additional therapy.</p>\u0000 \u0000 <p>\u0000 <b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT05426616</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 8","pages":"1136-1146"},"PeriodicalIF":5.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Synergetic Effect of Periodontal Therapy and TNF-α Inhibitor for the Treatment of Comorbid Periodontitis and Psoriasis","authors":"Crystal Marruganti,&nbsp;Carlo Gaeta,&nbsp;Chiara Falciani,&nbsp;Elisa Cinotti,&nbsp;Pietro Rubegni,&nbsp;Mario Alovisi,&nbsp;Nicola Scotti,&nbsp;Andrea Baldi,&nbsp;Cristiana Bellan,&nbsp;Chiara Defraia,&nbsp;Elena Bertaggia,&nbsp;Fabio Fiorino,&nbsp;Silvia Valensin,&nbsp;Erika Bellini,&nbsp;Antonella De Rosa,&nbsp;Filippo Graziani,&nbsp;Francesco D'Aiuto,&nbsp;Simone Grandini","doi":"10.1111/jcpe.14102","DOIUrl":"10.1111/jcpe.14102","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To assess the adjunctive effect of periodontal therapy on psoriasis-related outcomes in a combined experimental model of ligature-induced periodontitis and Imiquimod (IMQ)-induced psoriasis. Also, this experiment aimed to study the impact of TNF-α inhibitors on the periodontium.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Fifty-six C57/BL6J mice were randomly allocated to seven experimental groups: (a) control group (P–Pso–) with no treatment; (b) periodontitis (P+Pso–) with periodontal therapy; (c) periodontitis (P+Pso–) with TNF-α inhibitor; (d) psoriasis (P–Pso+) with TNF-α inhibitor; (e) periodontitis and psoriasis (P+Pso+) with periodontal therapy; (f) P+Pso+ with TNF-α inhibitor; and (g) P+Pso+ with both periodontal therapy and TNF-α inhibitor. Samples (maxilla, dorsal skin and blood) were harvested immediately after death. Measures of periodontitis distance between the cemento-enamel junction and alveolar bone crest (CEJ–ABC) and number of osteoclasts and psoriasis (epidermal thickness and infiltrate cells (per 0.03mm²)) severity, as well as systemic inflammation (IL-6, IL-17A and TNF-α) were collected.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In the P+Pso+ group, a significant adjunctive effect of periodontal therapy to TNF-α inhibitors was found in the reduction of epidermal thickening and inflammatory infiltrate of the dorsal skin (<i>p</i> &lt; 0.05). Similarly, treatment with TNF-α inhibitor resulted in a significant adjunctive effect to periodontal therapy in the reduction of alveolar bone loss (<i>p</i> &lt; 0.05). These changes were accompanied by a significant decrease in the circulating levels of IL-6 and IL-17A when both periodontal therapy and TNF-α inhibitor were administered.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The combination of periodontal therapy and TNF-α inhibitor showed a positive synergetic effect in the treatment of comorbid experimental ligature-induced periodontitis and IMQ-induced psoriasis via the reduction of systemic inflammation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 6","pages":"907-919"},"PeriodicalIF":5.8,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14102","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-Year Outcomes of Dental Implants With a Hybrid Surface Macro-Design Placed in Patients With History of Periodontitis: A Randomised Clinical Trial","authors":"Benjamín Serrano,&nbsp;Ignacio Sanz-Sánchez,&nbsp;Eduardo Montero,&nbsp;Mariano Sanz","doi":"10.1111/jcpe.14153","DOIUrl":"10.1111/jcpe.14153","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This randomised controlled trial (RCT) with a 3-year follow-up was aimed at assessing the clinical and radiographic outcomes of implants with either a hybrid or moderately rough macro-surface design placed in patients with a history of periodontitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Forty periodontitis subjects with a stable periodontal condition were included and randomly assigned to receive either a hybrid implant with a machined-collar surface (HS) or a conventional implant with a moderately rough-collar surface up to the shoulder (RS). Radiographic, clinical, microbiological and patient-related outcome measurements (PROMs) were assessed at baseline (implant loading) and 3, 6, 12, 24 and 36 months post-loading.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Thirty-six patients (17 and 19, in the test and control groups, respectively) completed the three-year follow-up. At this visit, mean marginal bone level (MBL) changes were −0.08 (SD 0.2) and 0.02 (SD 0.28) mm for the test and control groups, respectively, with only three patients exhibiting MBLs exceeding 1 mm and only one implant with a peri-implantitis diagnosis. Patients in both groups showed a high degree of satisfaction, and implants in both groups harboured a similar proportion and counts of measured periodontal pathogens. No significant differences were observed between the two groups regarding any of the radiographic, clinical or microbiological variables.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>At the three-year follow-up, both implant groups demonstrated high peri-implant bone stability, as well as a low incidence of peri-implant diseases.</p>\u0000 \u0000 <p>\u0000 <b>Trial Registration:</b> ClinicalTrials.gov (identifier NCT05010382). https://clinicaltrials.gov/ct2/show/NCT05010382?cond=peri-implantitis&amp;cntry=ES&amp;city=Madrid&amp;draw=2&amp;rank=5\u0000 </p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 6","pages":"802-812"},"PeriodicalIF":5.8,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Host Markers of Periodontal Diseases: Meta-Analysis of Diagnostic Accuracy Studies","authors":"Mia Rakic,&nbsp;Elena Calciolari,&nbsp;Melissa M. Grant,&nbsp;Sandro Radovanovic,&nbsp;Nagihan Bostanci,&nbsp;Philip M. Preshaw","doi":"10.1111/jcpe.14167","DOIUrl":"10.1111/jcpe.14167","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To identify host markers with optimal diagnostic performance for clinical implementation in the diagnosis of periodontal diseases and prediction of future disease progression and/or disease resolution.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Cross-sectional and prospective studies with ≥ 20 participants per group, reporting diagnostic accuracy (e.g., area under the curve [AUC]) of host markers for periodontal diagnosis (focused question 1 [FQ1]), periodontitis progression/relapse (FQ2) or resolution (FQ3) were searched in three electronic databases. Meta-analyses estimating diagnostic accuracy (DA) for individual host markers and for grouped salivary and gingival crevicular fluid (GCF) markers independently were performed whenever two or more studies were identified.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Sixty-one eligible studies were identified, of which 13 were included in meta-analyses for FQ1 (discrimination between health and periodontitis). Matrix metalloproteinase-8 (MMP-8) was the most reported biomarker in both saliva and GCF, with comparable AUC (0.70–0.90), sensitivity (0.49–0.84) and specificity (0.62–0.79) in both sample types. Cytokines had good ability for discrimination of periodontitis/gingivitis versus health, although they were substantially less accurate for periodontitis versus gingivitis. Combinations of cytokines and MMPs tended to increase overall diagnostic accuracy but without significant improvement in the case of periodontitis/gingivitis discrimination. Bone markers were the best performing group of salivary markers (AUC = 0.91) when compared to cytokines (AUC = 0.86) and MMPs (AUC = 0.77). GCF microRNAs (MiRs) were a singly meta-analysed group of biomarkers demonstrating AUC = 0.79.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Reported studies on host periodontal markers exhibit serious limitations regarding clinical and validation standards, being the main cause for lack of progress in clinical implementation of biomarkers in periodontal classification. Disease-specific markers such as bone markers showed better diagnostic performance (from limited number of studies) for the diagnosis of periodontitis when compared to cytokines and MMPs.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 S29","pages":"155-181"},"PeriodicalIF":5.8,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143849608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-Centred Preferences for Autonomy and Information-Seeking Among Periodontal Patients in Dental Decision Making","authors":"Ji-Young Jung,&nbsp;Kyung-A Ko,&nbsp;Franz J. Strauss,&nbsp;Jae-Hong Lee,&nbsp;Jun-Hewk Kim,&nbsp;Jung-Seok Lee","doi":"10.1111/jcpe.14166","DOIUrl":"10.1111/jcpe.14166","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aim</h3>\u0000 \u0000 <p>Managing periodontal disease often involves complex decisions involving multiple treatment options, and patient autonomy significantly influences this decision-making process. This study aimed to characterise the autonomy and information-seeking preferences among patients diagnosed with stage III/IV periodontitis, and to identify the factors influencing these preferences.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>The survey included 96 patients diagnosed with periodontal disease, all of whom underwent periodontal treatment or tooth extraction between May 2021 and February 2022. Participants completed a self-administered questionnaire incorporating the Autonomy Preference Index (API) to assess their decision-making and information-seeking preferences, along with demographic information, using a 5-point Likert scale.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Decision-making preferences were centrally distributed, with a score of 2.87 ± 0.47 (mean ± SD), indicating that most periodontal patients favoured a collaborative decision-making model. In contrast, information-seeking preferences were skewed, with a strong concentration towards the higher end of information preferences; the score was 4.55 ± 0.08. Lower age (<i>p</i> = 0.008) was associated with a preference for greater autonomy, while the financial burden (<i>p</i> = 0.034) was linked to reduced information-seeking preferences. Patients' autonomy remained relatively consistent across different periodontal clinical scenarios.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These findings suggest that periodontitis patients prefer to be well informed and share decision-making responsibilities with healthcare professionals after their diagnosis. Factors such as age and financial burden affect their autonomy, involvement and desire for information.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 7","pages":"960-970"},"PeriodicalIF":5.8,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14166","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143841304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}