Journal of Clinical Periodontology最新文献

Stability of Augmented Bone and Its Influencing Factors After Simultaneous Guided Bone Regeneration With Implant Placement in the Posterior Mandible: A Retrospective Study 后下颌骨同时引导骨再生与种植体植入后增强骨的稳定性及其影响因素：回顾性研究

IF 6.7 1区医学

Journal of Clinical Periodontology Pub Date : 2025-07-11 DOI: 10.1111/jcpe.14206

Xiaoyu Chen, Wenting Qi, Siyuan Wang, Antian Xu, Hongye Lu, Xiaoting Shen, Fuming He

{"title":"Stability of Augmented Bone and Its Influencing Factors After Simultaneous Guided Bone Regeneration With Implant Placement in the Posterior Mandible: A Retrospective Study","authors":"Xiaoyu Chen, Wenting Qi, Siyuan Wang, Antian Xu, Hongye Lu, Xiaoting Shen, Fuming He","doi":"10.1111/jcpe.14206","DOIUrl":"https://doi.org/10.1111/jcpe.14206","url":null,"abstract":"AimTo analyse the stability of augmented bone and its influencing factors after simultaneous guided bone regeneration (GBR) with implant placement in the posterior mandible.Materials and MethodsA total of 165 implants in 102 patients were included. General information, peri‐implant soft‐tissue parameters and complications were recorded. Cone‐beam computed tomography images at preoperative (T0), immediate postoperative (T1), post‐healing (T2) and the latest follow‐up (T3) were collected. Buccal bone width, height, bone distance (BD) and augmented bone volume (ABV) were assessed. Bone augmentation range was classified into inside‐contour (IC) group and outside‐contour (OC) group based on BD values. Factors influencing the augmented bone volume resorption rate (ABV%) were analysed.ResultsDuring the follow‐up period of 12–88 months, the mean ABV% was 47.56% ± 20.29%, predominantly occurring between T1 and T2. The OC group showed higher ABV% compared to the IC group (p < 0.001). BD of the IC and 0–1 mm OC groups was less than 0, while BD of the 1–2 and > 2 mm OC groups was near 0 at T3. Bone augmentation range (p < 0.001), non‐contained defects (p = 0.001) and 2‐mm healing abutments (p = 0.008) significantly influenced ABV%.ConclusionsSimultaneous GBR with implant placement in the posterior mandible provided predictable volumetric stability of the augmented bone. OC grafts resorbed towards individual phenotypical dimensions, whereas 1–2 mm over‐augmentation might optimise contour maintenance. Non‐contained defects compromised volumetric stability, while the 2‐mm healing abutments enhanced stability compared to cover screws.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"149 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144603083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

KAT6A Promotes Macrophage Inflammation and Periodontitis KAT6A促进巨噬细胞炎症和牙周炎

IF 6.7 1区医学

Journal of Clinical Periodontology Pub Date : 2025-07-10 DOI: 10.1111/jcpe.14203

Shi‐Jia Huang, Shuo Xu, Hui‐Lin Ye, Lu‐Jun Zhou, Yong‐Li Wang, Sheng‐Zhong Duan

{"title":"KAT6A Promotes Macrophage Inflammation and Periodontitis","authors":"Shi‐Jia Huang, Shuo Xu, Hui‐Lin Ye, Lu‐Jun Zhou, Yong‐Li Wang, Sheng‐Zhong Duan","doi":"10.1111/jcpe.14203","DOIUrl":"https://doi.org/10.1111/jcpe.14203","url":null,"abstract":"Both epigenetic modification and immunoregulation play important roles in periodontitis (PD). However, the function of macrophage lysine acetyltransferase 6A (KAT6A) in PD remains unknown. In this study, we first analysed single‐cell RNA sequencing data and demonstrated up‐regulated KAT6A expression in periodontal tissue macrophages of PD patients. Subsequently, macrophage KAT6A knockout (MK6AKO) mice were generated and subjected to PD induction by a combination of molar ligation and application of Porphyromonas gingivalis (Pg). Morphological analyses showed significantly decreased alveolar bone resorption in MK6AKO mice, and qRT‐PCR analysis showed markedly attenuated expression of inflammatory genes in the gingiva of MK6AKO mice compared to littermate mice after PD induction. RNA‐seq of peritoneal macrophages stimulated with Pg lipopolysaccharides (Pg‐LPS) unveiled down‐regulation of inflammatory pathways, particularly the interleukin 17 pathway in MK6AKO macrophages. Flow cytometry analysis detected a notable reduction of neutrophils in the gingiva of MK6AKO mice after PD induction. Furthermore, using the Cut&tag technique, we identified reduced histone H3K27 acetylation levels at nuclear factor kappa‐B binding sites on promoters of interleukin 1β and tumour necrosis factor in MK6AKO macrophages treated with Pg‐LPS. In summary, our study highlights the significant role of KAT6A in modulating macrophage phenotypes and the progression of PD, suggesting the therapeutic potential of targeting KAT6A.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"109 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144593896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Periodontal Condition With Serum C‐Reactive Protein Levels: The Role of Serum Apolipoproteins' Concentration 牙周状况与血清C反应蛋白水平的关系：血清载脂蛋白浓度的作用

IF 6.7 1区医学

Journal of Clinical Periodontology Pub Date : 2025-07-10 DOI: 10.1111/jcpe.14202

Anniina Haro, Tuomas Saxlin, Anna Liisa Suominen, Antti Jula, Pekka Ylöstalo

{"title":"Association of Periodontal Condition With Serum C‐Reactive Protein Levels: The Role of Serum Apolipoproteins' Concentration","authors":"Anniina Haro, Tuomas Saxlin, Anna Liisa Suominen, Antti Jula, Pekka Ylöstalo","doi":"10.1111/jcpe.14202","DOIUrl":"https://doi.org/10.1111/jcpe.14202","url":null,"abstract":"AimTo investigate whether the systemic inflammatory response against inflammatory conditions in the periodontium is related to serum apolipoprotein B (ApoB) and A1 (ApoA1) concentrations.Material and MethodsThe study consisted of the Health 2000 Survey participants (n = 2709) aged 30–49 years. The inflammatory condition of the periodontium was assessed by means of the number of teeth with deepened (≥ 4 mm) and deep (≥ 6 mm) periodontal pockets. Systemic inflammation was measured by serum C‐reactive protein (CRP) levels. The role of ApoB and ApoA1 was studied by performing regression analyses and stratified analyses (according to the median values).ResultsIn logistic regression analyses, the number of teeth with deepened (≥ 4 mm) periodontal pockets was associated with serum CRP levels among those participants whose serum ApoB concentration was ≥ 1.12 g/L. When the participants' ApoB concentration was < 1.12 g/L, such an association between deepened periodontal pockets and CRP was not observed. The direction or strength of the association between periodontal pockets and CRP was not essentially different in the ApoA1 strata.ConclusionSystemic response against poor periodontal condition varied between individuals. The variation appeared to be related more to the serum concentration of ApoB than ApoA1.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"51 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144603085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Treatment Endpoints After Active Periodontal Treatment and 10 Years of Supportive Periodontal Care: A Retrospective Cohort Study 积极牙周治疗和10年支持牙周护理后的临床治疗终点：一项回顾性队列研究

IF 6.7 1区医学

Journal of Clinical Periodontology Pub Date : 2025-07-09 DOI: 10.1111/jcpe.14179

Mario Schröder, Max Buchinger, Iulia Dahmer, Peter Eickholz, Hari Petsos

{"title":"Clinical Treatment Endpoints After Active Periodontal Treatment and 10 Years of Supportive Periodontal Care: A Retrospective Cohort Study","authors":"Mario Schröder, Max Buchinger, Iulia Dahmer, Peter Eickholz, Hari Petsos","doi":"10.1111/jcpe.14179","DOIUrl":"https://doi.org/10.1111/jcpe.14179","url":null,"abstract":"ObjectivesComparing periodontal stability following active periodontal treatment (APT/T1) and 120 ± 12 months of supportive periodontal care (SPC/T2) using four clinical endpoints (CEPs).MethodsCEP1: pocket probing depths (PPD) ≤ 4 mm, no sites with ≥ 4 mm with bleeding on probing (BOP), and total BOP < 10%; CEP2: no PPD > 4 mm with BOP or PPD ≥ 6 mm; CEP3: ≤ 4 sites with PPD ≥ 5 mm; CEP4: ≤ 5 teeth with PPD ≥ 5 mm. Assuming CEPs are mutually exclusive, patient‐ and tooth‐related parameters (e.g., periodontal tooth loss: PTL) were compared. Using receiver operating characteristic analysis for the prediction of PTL as a cutoff for CEP was assessed.ResultsFrom 128 patients (age 65.5 ± 10.5 years; 83 stage III, 45 stage IV; 47 grade B, 81 grade C), 7 achieved CEP1, 23 CEP2, 45 CEP3, 23 CEP4, 30 noCEP at T1. At T2, six patients reached CEP1, 37 CEP2, 38 CEP3, 35 CEP4, 12 noCEP. For noCEP, the number of sites with PPD > 5 mm increased significantly, and PTL was higher compared to CEP1, CEP2 and CEP3 (p < 0.001).ConclusionsWhile achieving CEP1 is possible through comprehensive APT, treating a chronic disease often leads to less ideal CEP2/CEP3. Achieving CEP1, CEP2 or CEP3 after APT made no observable difference regarding PTL.Trial Registration: The study is registered with the United States National Library of Medicine in the clinical trials database (URL: https://clinicaltrials.gov; NCT03048045)","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"33 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endpoints of Periodontal Therapy in Elderly Patients With Stage III/IV Periodontitis and Their Oral Health–Related Quality of Life Following 10 Years of Supportive Periodontal Therapy 老年III/IV期牙周炎患者的牙周治疗终点及10年牙周支持性治疗后口腔健康相关生活质量

IF 6.7 1区医学

Journal of Clinical Periodontology Pub Date : 2025-07-07 DOI: 10.1111/jcpe.14198

Caspar Victor Bumm, Sophie Gaenesch, Florian Nagler, Iris Frasheri, Falk Schwendicke, Vinay Pitchika, Christina Ern, Richard Heym, Charlotte Wetzel, Matthias Folwaczny, Nils Werner

{"title":"Endpoints of Periodontal Therapy in Elderly Patients With Stage III/IV Periodontitis and Their Oral Health–Related Quality of Life Following 10 Years of Supportive Periodontal Therapy","authors":"Caspar Victor Bumm, Sophie Gaenesch, Florian Nagler, Iris Frasheri, Falk Schwendicke, Vinay Pitchika, Christina Ern, Richard Heym, Charlotte Wetzel, Matthias Folwaczny, Nils Werner","doi":"10.1111/jcpe.14198","DOIUrl":"https://doi.org/10.1111/jcpe.14198","url":null,"abstract":"AimTo investigate clinical endpoints of periodontal therapy after steps 1 and 2 of therapy and their association with oral health–related quality of life (OHRQoL) following long‐term supportive periodontal therapy (SPT).Materials and MethodsForty‐seven patients receiving SPT for 126 ± 30 months were included. Clinical endpoints of therapy, as proposed by the EFP (PPD ≤ 3 mm, ≤ 5 mm without bleeding on probing), and a treat‐to‐target endpoint (T2T; ≤ 4 sites with PPD of ≥ 5 mm) were determined following steps 1 and 2 of therapy (T1) and were associated with patients' OHRQoL using the Oral Health Impact Profile (OHIP)‐14 as well as tooth loss (TL) and self‐reported tooth migration 126 ± 30 months after step 2 (T2).ResultsOne patient achieved the EFP endpoint and 16 achieved T2T, and 30 patients failed to achieve any endpoint at T1. OHRQoL at T2 did not differ significantly between patients achieving or not achieving the endpoints (p = 0.485). Self‐reported tooth migration during the examination period was significantly associated with poorer OHRQoL (p = 0.009).ConclusionsOHRQoL has become a major subject of periodontal research. Within the limitations of this study, achieving clinical endpoints does not seem to affect patients' OHRQoL following long‐term SPT. Patients reporting on tooth migration, however, showed significantly reduced OHRQoL. Besides clinical endpoints, functional and aesthetic complaints of periodontally compromised patients should be considered when evaluating the success of therapy.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"685 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the Link Between Oral Microbiome Diversity and Biological Ageing: A Cross‐Sectional Study 揭示口腔微生物群多样性与生物老化之间的联系：一项横断面研究

IF 6.7 1区医学

Journal of Clinical Periodontology Pub Date : 2025-07-07 DOI: 10.1111/jcpe.14172

Jiarui Hou, Anli Weng, Zhiwen Yang, Xuchun Huang, Wenting Chen, Xiaoyun Wang

{"title":"Unveiling the Link Between Oral Microbiome Diversity and Biological Ageing: A Cross‐Sectional Study","authors":"Jiarui Hou, Anli Weng, Zhiwen Yang, Xuchun Huang, Wenting Chen, Xiaoyun Wang","doi":"10.1111/jcpe.14172","DOIUrl":"https://doi.org/10.1111/jcpe.14172","url":null,"abstract":"AimTo investigate the relationship between oral microbiome diversity and biological ageing acceleration in a nationally representative U.S. sample.MethodsData from 7716 participants in NHANES (2009–2012) were analysed. Oral microbiome diversity was assessed, and biological ageing acceleration was calculated using a validated algorithm. Generalised linear models, restricted cubic splines and smooth curve fitting were applied to evaluate associations.ResultsHigher α‐diversity of the oral microbiome was significantly negatively correlated with biological ageing acceleration. Stratified analyses revealed that this protective effect was particularly pronounced in men and individuals with hypertension and diabetes. β‐Diversity analysis showed significant differences in the association between microbial community composition and biological ageing acceleration, with immune functions potentially modulating these effects. Furthermore, key intervals of α‐diversity were identified, which may serve as potential targets for future research on delaying ageing.ConclusionsIn the general U.S. population, greater oral microbiome diversity was associated with lower biological ageing acceleration, especially among men and those with hypertension and diabetes. This association was also observed in Mexican and Hispanic populations.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"85 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the Clinical Efficacy of Copine 7‐Derived Peptides for Naturally Occurring Periodontitis in Dogs 评价Copine - 7衍生肽治疗犬自然牙周炎的临床疗效

IF 6.7 1区医学

Journal of Clinical Periodontology Pub Date : 2025-07-07 DOI: 10.1111/jcpe.14200

Se Eun Kim, Hyeonu Sung, Sehan Shin, Jinhee Bae, Giyeon Kim, Dong‐Seol Lee, Han Woong Kim, Jin‐Seok Seo, Song Yi Roh, Su‐Jin Park, Chul Son, Seong Min Roh, Jeongmin Park, Joo‐Cheol Park

{"title":"Evaluation of the Clinical Efficacy of Copine 7‐Derived Peptides for Naturally Occurring Periodontitis in Dogs","authors":"Se Eun Kim, Hyeonu Sung, Sehan Shin, Jinhee Bae, Giyeon Kim, Dong‐Seol Lee, Han Woong Kim, Jin‐Seok Seo, Song Yi Roh, Su‐Jin Park, Chul Son, Seong Min Roh, Jeongmin Park, Joo‐Cheol Park","doi":"10.1111/jcpe.14200","DOIUrl":"https://doi.org/10.1111/jcpe.14200","url":null,"abstract":"AimTo assess the efficacy of copine7‐derived peptide (CPNE7‐DP) applied in conjunction with non‐surgical dental treatments in improving naturally occurring periodontitis in dogs.Materials and MethodsThis study included 24 client‐owned dogs with mild to moderate periodontitis, randomly assigned to three groups: CPNE7‐DP; a placebo control group receiving carrier material; and a negative control group left untreated. Experimental agents were applied after professional dental cleaning. Clinical assessments were conducted at Weeks 0, 4 and 8, which involved measurements of gingival index (GI), periodontal pocket depth (PPD), clinical attachment loss (CAL) and bleeding on probing (BoP). Alveolar bone loss (ABL) was evaluated using intraoral radiographs.ResultsApplication of CPNE7‐DP resulted in a significant improvement in GI, PPD, CAL and BoP compared with both placebo and negative control groups. ABL was significantly reduced in the CPNE7‐DP group. These clinical outcomes indicated the potential regenerative effects of CPNE7‐DP on periodontal tissues.ConclusionsTopical application of CPNE7‐DP in conjunction with non‐surgical dental treatments was effective in reducing gingival inflammation, PPD, CAL and ABL in dogs with naturally occurring periodontitis. These findings suggest the potential of CPNE7‐DP as an effective adjunctive therapeutic agent for periodontal treatment.Trial Registration: Approved by the Institutional Animal Care and Use Committee of Seoul National University (SNU‐220520‐5‐1)","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"13 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scandinavian and North American Moist Snuff and Periodontitis: A Systematic Review and Meta-Analysis. 斯堪的纳维亚和北美湿鼻烟和牙周炎：系统回顾和荟萃分析。

IF 6.7 1区医学

Journal of Clinical Periodontology Pub Date : 2025-06-25 DOI: 10.1111/jcpe.14197

Mai Soon Solberg,Anne Isine Bolstad,Stein Atle Lie,Siddharth Shanbhag,Dagmar Fosså Bunæs

{"title":"Scandinavian and North American Moist Snuff and Periodontitis: A Systematic Review and Meta-Analysis.","authors":"Mai Soon Solberg,Anne Isine Bolstad,Stein Atle Lie,Siddharth Shanbhag,Dagmar Fosså Bunæs","doi":"10.1111/jcpe.14197","DOIUrl":"https://doi.org/10.1111/jcpe.14197","url":null,"abstract":"AIMTo answer the focused PECOS question: in humans (P), what is the effect of Scandinavian or North American moist snuff (MS) (E), in comparison to non-use (C), in terms of periodontitis (O) as demonstrated in clinical studies (S)?METHODSElectronic databases (MEDLINE, EMBASE and Cochrane) and grey literature were searched for relevant studies reporting clinical and/or patient-reported periodontal outcomes. Qualitative and quantitative syntheses (random-effects meta-analysis with pooled odds ratios [ORs] or effect sizes [ESs] and 95% confidence intervals [CIs]) were performed to determine the associations between MS use and primary (periodontitis) or secondary outcomes (gingival recession, gingivitis). Risk of bias (Newcastle-Ottawa scale) and certainty of evidence (GRADE) were assessed.RESULTSTwenty-two mostly cross-sectional studies from Sweden (n = 11), the United States (n = 10) and Norway (n = 1) were included. MS use was most frequently associated with buccal recession. Qualitatively, an association between MS use and periodontitis (n = 16) was judged to be unlikely. Based on studies with high clinical heterogeneity, no significant associations were found between MS use and periodontitis (n = 2 [12,775 participants], OR = 1.49 [CI: 0.71-3.16]), recessions (n = 9 [3719 participants], ES = -0.04 [CI: -0.98 to 0.90]) or gingivitis (n = 3 [1429 participants], ES = 0.09 [CI: -0.36 to 0.55]). The certainty of evidence was judged to be very low.CONCLUSIONThe current evidence, mostly based on cross-sectional studies and very low certainty, suggests that Scandinavian or North American MS use is not associated with periodontitis.PROSPEROCRD42023417652.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"243 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144488268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging Technologies and Algorithms for Periodontal Screening and Risk of Disease Progression in Non-Dental Settings: A Scoping Review. 新兴技术和算法牙周筛查和疾病进展的风险在非牙科设置：范围审查。

IF 6.7 1区医学

Journal of Clinical Periodontology Pub Date : 2025-06-25 DOI: 10.1111/jcpe.14168

Eduardo Montero,Nerea Sánchez,Ignacio Sanz-Sánchez,Mercedes López-Durán,Ana Carrillo de Albornoz,Thomas Dietrich

{"title":"Emerging Technologies and Algorithms for Periodontal Screening and Risk of Disease Progression in Non-Dental Settings: A Scoping Review.","authors":"Eduardo Montero,Nerea Sánchez,Ignacio Sanz-Sánchez,Mercedes López-Durán,Ana Carrillo de Albornoz,Thomas Dietrich","doi":"10.1111/jcpe.14168","DOIUrl":"https://doi.org/10.1111/jcpe.14168","url":null,"abstract":"AIMTo evaluate different tools to screen for periodontal diseases and/or evaluate the risk for disease progression in non-dental clinical settings.MATERIALS AND METHODSThe PRISMA Extension for Scoping Reviews (PRISMA-ScR) guideline was followed. A systematic search was conducted on three databases. In order to provide a comprehensive picture of periodontal diseases (Population) screening and risk assessment tools (Concept) in non-dental settings (Context), the available information was identified and presented in terms of the sources of data/domains assessed and, eventually, how the tools/algorithms were validated. The risk of bias was assessed using the QUADAS-2 tool.RESULTSA total of 5313 articles were identified for abstract screening. Finally, 102 were included for data synthesis. The included studies were classified into domains/clusters. Only two studies focused on risk assessment for disease progression. Algorithms designed to screen for gingivitis tended to present low sensitivity values, while the screening performance improved for periodontitis, particularly for severe periodontitis. Validated self-reported questionnaires plus socio-demographic determinants (e.g., age), certain biomarkers in saliva (e.g., activated matrix metalloproteinase-8, aMMP-8) and artificial intelligence (AI) algorithms based on orthopantomographs (OPGs) present the best screening capacity for periodontitis.CONCLUSIONSScreening for periodontitis in non-dental settings is feasible. Validated self-reported questionnaires remain the gold standard for screening severe periodontitis in non-dental settings, although AI algorithms based on biomarkers in saliva, or derived from OPGs, have shown promising results.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"639 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics of Subgingival Plaque Microbiome in Japanese Older Adults With Healthy Gingiva. 具有健康牙龈的日本老年人龈下菌斑微生物群特征

IF 6.7 1区医学

Journal of Clinical Periodontology Pub Date : 2025-06-24 DOI: 10.1111/jcpe.14192

Tomoki Akatsu,Hatsumi Souno,Akihiko Fujii,Yoshihiko Minegishi,Noriyasu Ota,Yoshihisa Yamashita

{"title":"Characteristics of Subgingival Plaque Microbiome in Japanese Older Adults With Healthy Gingiva.","authors":"Tomoki Akatsu,Hatsumi Souno,Akihiko Fujii,Yoshihiko Minegishi,Noriyasu Ota,Yoshihisa Yamashita","doi":"10.1111/jcpe.14192","DOIUrl":"https://doi.org/10.1111/jcpe.14192","url":null,"abstract":"AIMTo elucidate the characteristics of the subgingival plaque microbiome in older adults without gingival inflammation.MATERIALS AND METHODSSubgingival plaque from 180 participants was collected and analysed using 16S rRNA sequencing. Based on the clinical parameters at the sampling sites, participants were categorised as healthy (gingival index [GI] = 0, maximum probing pocket depth [PPDmax] ≤ 2.0 and gingival recession [GR] = 0) or non-healthy (GI > 0, or PPDmax > 2.0 or GR > 0). Each group was further stratified by age into younger (< 65 years) and older (≥ 65 years) subgroups. We performed diversity and linear discriminant effect size (LEfSe) analyses to elucidate microbiome characteristics of healthy older adults.RESULTSWe observed differences in α-diversity and β-diversity between younger and older individuals only in the healthy group. Healthy older individuals showed a lower α-diversity index, indicating a healthy-like profile shift and also a significantly greater difference in β-diversity from the non-healthy group than the healthy younger subgroup. LEfSe analysis indicated that six amplicon sequence variants (ASVs), such as Rothia dentocariosa, Neisseria perflava and Actinomyces sp. HMT-448, were predominant in the healthy older subgroup.CONCLUSIONMaintaining lower α-diversity, with an abundance of R. dentocariosa and N. perflava, which are possible nitrate-reducing bacteria, may contribute to lifelong healthy gingiva by preventing microbial dysbiosis.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"7 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0