Journal of Clinical Periodontology最新文献

{"title":"Efficacy of Injectable Bone Fillers for Alveolar Ridge Preservation: A Histomorphometrical Analysis.","authors":"Frank Schwarz,Ausra Ramanauskaite,Karina Obreja,Jonas Lorenz,Robert Sader,Puria Parvini","doi":"10.1111/jcpe.14162","DOIUrl":"https://doi.org/10.1111/jcpe.14162","url":null,"abstract":"AIMTo assess the efficacy of injectable bone fillers for alveolar ridge preservation (ARP).MATERIALS AND METHODSThe mandibular premolars (P2, P3, P4) were bilaterally assigned to ARP in a total of n = 9 beagle dogs. Each P was decapitated and hemisected under preservation of the mesial (i.e., devitalization and filling with calcium hydroxide) and removal of the distal root. The resulting 6 extraction sockets were randomly allocated to a total of four injectable test materials (i.e., bovine bone particles + porcine collagen, lyophilized materials reconstituted with either blood or saline [T1, T2, T4]; or ready-to-use wet material [T3]) and one control material (collagenated bovine bone mineral) (C) as well as one negative control group (N). Primary wound closure was ensured in all test and C groups. At 12 weeks, dissected blocks were prepared for histomorphometrical analyses. Buccal bone height (BBH) was defined as a primary outcome. Lingual bone height (LBH), buccal and lingual bone wall width (BBW and LBW 1, 3 and 5 mm infracrestally), surface area of bone and particles, fibrous tissues, and bone marrows were defined as secondary outcomes. Between-group comparisons were assessed using ANOVA and Mann-Whitney tests.RESULTSAfter 12 weeks, all groups were associated with similar BBH values (BBH: 14.1, 14.0, 13.7, 13.8, 14.3 and 114.2 mm in the T1, T2, T3, T4, C and N groups, respectively; p > 0.05 for all between-group comparisons). The BBW and LBW measurements were comparable among the groups. ARP sites showed a trend towards higher area measurements of bone and particle surfaces compared with the N group (11.5, 11.6, 13.1, 12.5, 9.1 mm2 in T1, T2, T3, T4, C and N groups, respectively). C, T1, T2, T3 and T4 particles were associated with a similar marked grade of osteoconduction and osteointegration within the former extraction socket area.CONCLUSIONSWithin its limitations, the present study has pointed to the similar efficacy of injectable bone fillers for ARP compared with the particulated bone substitute and negative control.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"39 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143822687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Biomarkers for Periodontal Diseases: A Systematic Review.","authors":"H Dommisch, D Hoedke, E M-C Lu, A Schäfer, G Richter, J Kang, L Nibali","doi":"10.1111/jcpe.14149","DOIUrl":"https://doi.org/10.1111/jcpe.14149","url":null,"abstract":"<p><strong>Aims: </strong>To identify genetic biomarkers that may be used in the diagnosis, prevention or management of different forms of periodontal disease.</p><p><strong>Materials and methods: </strong>Following protocol registration and PICOTS (patient, intervention, comparison, outcome, time, studies) questions, a systematic search of the literature was conducted (PudMed, Ovid), resulting in 1592 papers screened by two reviewers. Diagnostic data were extracted or calculated from included papers and compared with clinically determined diagnoses, disease progression and/or response to treatment.</p><p><strong>Results: </strong>A total of 607 articles met the inclusion criteria, including 10 reporting data on gingivitis and 597 on periodontitis. Only two papers reported diagnostic performance data, while for 41 articles on large candidate gene studies, diagnostic performance could be calculated from the reported data. No study using chair-side tests was identified. Low to moderate values for sensitivity, specificity, positive and negative predictive value and diagnostic accuracy were found.</p><p><strong>Conclusion: </strong>No genetic diagnostic test of clinical value emerged for periodontal diagnosis, prevention or prediction of disease resolution. Thus, potential future applications of polygenic risk scores that encode susceptibility, as well as single-marker testing for monogenic or oligogenic forms of periodontal diseases, are discussed.</p>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-Driven Detection and Measurement of Keratinized Gingiva in Dental Photographs: Validation Using Reference Retainers.","authors":"Ya-Chi Chen, Ling Chen, Yu-Lin Lai, Wei-Ting Chang, Shyh-Yuan Lee","doi":"10.1111/jcpe.14164","DOIUrl":"https://doi.org/10.1111/jcpe.14164","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate a deep learning (DL) model for detecting keratinized gingiva (KG) in dental photographs and validate its clinical applicability using reference retainers for calibration.</p><p><strong>Materials and methods: </strong>A total of 576 sextant photographs were selected from 32 subjects, each with three sets of photographs: iodine-stained, unstained and line-marked retainers. Relative keratinized gingiva width (rKGW) was measured using visual, functional and histochemical staining methods with reference retainers. A pre-trained DeepLabv3 model with ResNet50 backbone was fine-tuned to predict KG areas, which were then applied to the photographs with line-marked retainers for subsequent rKGW measurement.</p><p><strong>Results: </strong>The AI model achieved a Dice coefficient of 93.30% and an accuracy of 93.32%. Using histochemical measurements as gold standards, the absolute differences in rKGW of AI measurements were statistically insignificant with visual (p = 0.935) and functional (p = 0.979) measurements. The adjusted difference between AI and histochemical measurements was 0.377 mm. AI closely matched histochemical measurements in the maxillary anterior region (0.011 mm, p = 0.903) but was significantly higher in the maxillary posterior region (0.327 mm, p < 0.05).</p><p><strong>Conclusions: </strong>The proposed AI model is the first to reliably identify full-mouth KG, validated thoroughly using reference retainers. However, predictions for posterior teeth warrant further improvement.</p>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Real-World Evidence Study Evaluating Oral-Health-Related Quality of Life Following the Use of Anti-Sensitivity Toothpaste for Self-Reported Dentine Hypersensitivity Management.","authors":"Roberta Grimaldi, Sarah R Baker, Parth Shah, Edwin Sanchez, Gilbert Shanga, Paola R Gomez-Pereira, Charlie R Parkinson","doi":"10.1111/jcpe.14155","DOIUrl":"https://doi.org/10.1111/jcpe.14155","url":null,"abstract":"<p><strong>Aims: </strong>To evaluate the impact of an anti-sensitivity toothpaste on the oral-health-related quality of life (OHrQoL) in a real-world (RW) setting.</p><p><strong>Materials and methods: </strong>This was a decentralised, prospective, 24-week, open-label study in participants with self-reported dentine hypersensitivity (DH). A total of 655 enrolled participants used a 5% potassium nitrate toothpaste per label instructions and completed the Dentine Hypersensitivity Experience Questionnaire (DHEQ) and Numerical Pain Rating Scale (NPRS) monthly for 24 weeks and numerical scale for satisfaction of self-management of DH at 24 weeks. An ANOVA model was used to assess changes from baseline, overall and within subgroups (age ≤ 40, > 40 years, DH diagnosis confirmed or not by a dentist, use of sensitivity toothpaste [non-user, intermittent and current users] and DH frequency [frequent: several times a week; less frequent: less than once a week]).</p><p><strong>Results: </strong>The intent-to-treat population included 577 participants. At each timepoint, compared to baseline, improvements were statistically significant for all measures of OHrQoL (p < 0.0001, except Global Oral Health) and for NPRS (p < 0.0001) in the overall population and among subgroups (p < 0.05). All participants were highly satisfied with the product for self-management of DH.</p><p><strong>Conclusions: </strong>This study showed the effectiveness of an anti-sensitivity toothpaste in improving OHrQoL and self-reported DH in an RW setting, as measured by a validated questionnaire.</p>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Activation of PGC‐1 Alpha‐Dependent Mitochondrial Biogenesis Supports Therapeutic Effects of Silibinin Against Type I Diabetic Periodontitis”","authors":"","doi":"10.1111/jcpe.14148","DOIUrl":"https://doi.org/10.1111/jcpe.14148","url":null,"abstract":"","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"28 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic Azithromycin as an Adjunct to Non-Surgical Subgingival Instrumentation in the Treatment of Stage III/IV, Grade C Periodontitis: 12-Month Clinical, Microbiological and Cytokine Results of a Randomised Controlled Trial.","authors":"Srinivas Sulugodu Ramachandra, Valerie Woodford, Pingping Han, Ryan S B Lee, Sašo Ivanovski","doi":"10.1111/jcpe.14150","DOIUrl":"https://doi.org/10.1111/jcpe.14150","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the clinical, microbial and cytokine changes following the use of oral azithromycin as an adjunct to non-surgical subgingival instrumentation (NSI) in stage III/IV, grade C periodontitis through a triple-blind, parallel-armed, randomised controlled trial.</p><p><strong>Material and methods: </strong>A total of 52 patients with stage III/IV grade C periodontitis were randomly allocated to two groups receiving NSI with or without adjunctive azithromycin. The primary outcome was changes in the periodontal inflamed surface area (PISA) values over 12 months, and the secondary outcomes included changes in pocket depth (PD), clinical attachment loss (CAL), percentage of sites with PD of 1-3, 4-5, ≥ 5 and ≥ 6 mm, subgingival periodontal pathogens, cytokine levels and patient-reported outcomes.</p><p><strong>Results: </strong>At 3 and 12 months, there were no statistically significant differences in the reduction in PISA or other clinical parameters between the groups. At 3 months, the levels of several periodontal pathogens were significantly reduced in the azithromycin group. No significant differences were observed in the levels of periodontal pathogens at 12 months except for Prevotella intermedia. No significant differences were observed for the studied cytokines at 3 and 12 months.</p><p><strong>Conclusion: </strong>The results of this study do not support the use of systemic azithromycin in stage III/IV, grade C periodontitis.</p><p><strong>Trial registration: </strong>The trial was registered prospectively in the Australia New Zealand Clinical Trial Registry, ACTRN12619000560190. https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=374699.</p>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging Applications of Digital Technologies for Periodontal Screening, Diagnosis and Prognosis in the Dental Setting","authors":"Roberto Farina, Anna Simonelli, Leonardo Trombelli, Johanna B. Ettmayer, Jan L. Schmid, Christoph A. Ramseier","doi":"10.1111/jcpe.14156","DOIUrl":"https://doi.org/10.1111/jcpe.14156","url":null,"abstract":"AimTo comprehensively review digital technologies (including artificial intelligence, AI) for periodontal screening, diagnosis and prognosis in the dental setting, focusing on accuracy metrics.Materials and MethodsTwo separate literature searches were conducted for periodontal screening and diagnosis (part I, scoping review) and prognosis (part II, systematic approach). PubMed, Scopus and Embase databases were searched.ResultsIn part I, 40 studies evaluated AI and advanced imaging on different substrata. The combination of AI with 2D radiographs was the most frequently investigated and demonstrated a high level of periodontitis detection and stage definition. In part II, eight studies, identified as having a high risk of bias, tested supervised machine learning models using 6–74 predictors. The models demonstrated variable predictive accuracy, often outperforming traditional risk assessment tools and classical statistical models in the few studies evaluating such comparisons.ConclusionsAI and advanced imaging techniques are promising for periodontal screening, diagnosis and prognosis in the dental setting, although the evidence remains inconsistent and inconclusive. In addition, AI‐driven analysis of 2D radiographs (for diagnosis and staging of periodontitis), neural networks and the aggregation of multiple algorithms (for predicting tooth‐related outcomes) appear to be the most promising approaches entering clinical application.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"56 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methods for Clinical Assessment in Periodontal Diagnostics: A Systematic Review","authors":"I. H. Stødle, J.‐C. Imber, S. V. Shanbhag, G. E. Salvi, A. Verket, A. Stähli","doi":"10.1111/jcpe.14145","DOIUrl":"https://doi.org/10.1111/jcpe.14145","url":null,"abstract":"AimThis systematic review aimed to answer the following PECOS questions: In human subjects with untreated periodontitis (Q1) or enrolled in supportive periodontal care (SPC) (Q2) (P), are there clinical assessment methods (E) other than the contemporary manual probe (C) that increase diagnostic accuracy or reliability when examining/screening for periodontitis (Q1) or when monitoring disease stability or progression (Q2) (O) as demonstrated in clinical studies (S)?Material and MethodsA single search strategy was devised to identify relevant studies addressing Q1 and Q2 from four electronic databases. The main clinical parameters considered were probing depth (PD) and clinical attachment level (CAL). Risk of bias (RoB) was assessed using a modified Newcastle‐Ottawa scale.ResultsOf the 5417 identified titles, 26 studies were finally included. The evidence revealed that manual probes generally yielded higher PD values, while pressure‐sensitive/electronic probes demonstrated a trend for higher inter‐ and intra‐examiner reproducibility. No clear trend for the superiority of one probe over the other could be identified for Q1 or Q2.ConclusionsThe outcomes of the present systematic review indicated no clear benefit from the use of pressure‐sensitive/electronic probes over contemporary manual probes. Manual probes remain the clinical standard for the diagnosis and monitoring of periodontitis patients.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"33 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol Consumption, Risk of Periodontitis and Change of Periodontal Parameters in a Population‐Based Cohort Study","authors":"Sebastian‐Edgar Baumeister, Janka Schössow, Gustavo G. Nascimento, Henry Völzke, Thomas Kocher, Birte Holtfreter","doi":"10.1111/jcpe.14154","DOIUrl":"https://doi.org/10.1111/jcpe.14154","url":null,"abstract":"AimTo investigate the association of alcohol consumption with periodontitis risk and change in periodontal parameters over time.MethodsUsing data from 1285 participants of two population cohort studies embedded in the Study of Health in Pomerania, we associated baseline average alcohol consumption with incident periodontitis measured after a median follow‐up time of 5.0 years, adjusting for confounding and selection bias using multivariable regression and multiple imputation.ResultsBaseline alcohol intake was prospectively associated with a higher risk of periodontitis (relative risk of 1.08 (95% confidence interval: 1.06, 1.10) and 1.23 (1.17, 1.28) for 30 and 60 g per day (g/day) versus 10 g/day), deeper periodontal pockets, higher clinical attachment levels (CAL) and a higher proportion of sites with probing depths and CAL ≥ 3 mm and ≥ 4 mm.ConclusionsOur results support the hypothesis that higher alcohol intake modestly increases the risk of periodontitis. Sensitivity analysis suggested that unmeasured confounding and selection bias could explain the observed association.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"17 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Osseous Morphology Following Non‐Surgical Periodontal Therapy: A Possible Paradigm Shift for the Treatment of Intrabony Defects?","authors":"Luigi Nibali, Pierpaolo Cortellini","doi":"10.1111/jcpe.14141","DOIUrl":"https://doi.org/10.1111/jcpe.14141","url":null,"abstract":"Sub‐gingival non‐surgical periodontal therapy (NSPT) constitutes step 2 of periodontal therapy, aiming to disrupt the subgingival microbial biofilm and resolve or reduce inflammation of the supracrestal periodontal tissues. A plethora of original studies and reviews have been published over several decades, highlighting its fundamental importance in periodontal therapy and in tooth survival. Evidence shows that step 2 therapy leads to probing pocket depth reduction, associated with increase in gingival recession, clinical attachment level gain and improvements in patient‐reported outcome measures, as well as to a reduction in local and, to some extent, systemic inflammatory markers. In cases of intrabony defects, NSPT has traditionally been considered a necessary step to improve periodontal tissue tone and reduce inflammation, thus paving the way for the surgical step, such as periodontal regeneration. This commentary presents compelling arguments for a paradigm shift showing that step 2 therapy also leads to changes in osseous morphology, particularly evident in, but probably not limited to, intrabony defects. This introduces a new dawn, where attempts should be made to understand the mechanisms behind this phenomenon and to maximise the potential of non‐surgical therapy to achieve disease resolution and defect/pocket improvements while reducing patient morbidity even in complex periodontal defects.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"19 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}