Journal of Clinical Periodontology最新文献

{"title":"Childhood Famine Exposure and Late-Life Edentulism: Evidence From Natural Experiments.","authors":"Sebastian-Edgar Baumeister, Colman McGrath, Thomas Kocher, Gustavo G Nascimento","doi":"10.1111/jcpe.70190","DOIUrl":"10.1111/jcpe.70190","url":null,"abstract":"<p><strong>Aim: </strong>To examine whether childhood famine exposure affects late-life edentulism using natural experiments from Asia, Europe and America.</p><p><strong>Materials and methods: </strong>We utilised historical famines as exogenous shocks. Data were pooled from 10 population-based studies across eight countries (165,586 participants). Because the famine-exposed cohort is older at survey than the comparison cohort, we separated famine exposure from the birth-cohort age gradient using a regression discontinuity in time, an interrupted time series, a region-of-birth famine-intensity difference-in-differences, a pre-famine comparison cohort and applied negative controls.</p><p><strong>Results: </strong>The crude positive association (risk ratio [RR] 1.69) was eliminated after adjustment for current age (RR 1.07, 95% confidence interval (CI) 0.92-1.23), and the famine cohort did not differ from the older pre-famine cohort (RR 0.97). The regression discontinuity (+0.13% points, 95% CI: -1.50 to +1.77), interrupted time series (-4.01% points, p = 0.15) and the region-of-birth difference-in-differences in the two Chinese cohorts (unadjusted, both p ≥ 0.07) were null, as were all negative controls.</p><p><strong>Conclusions: </strong>Once the birth-cohort age gradient is accounted for, childhood famine exposure shows no detectable effect on late-life edentulism; the crude positive association is largely explained by age confounding, which cross-sectional famine-cohort comparisons do not address.</p>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":" ","pages":"1673-1680"},"PeriodicalIF":8.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13658044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoral Ultrasonography for Mid-Buccal Probing Depth Assessment: A Proof-of-Concept Clinical Agreement Study.","authors":"Sefa Aydindogan, Metehan Ozdemir, Yunus Emre Balaban, Elif Mutafcılar Velioğlu, Sema S Hakki, Kaan Orhan","doi":"10.1111/jcpe.70215","DOIUrl":"https://doi.org/10.1111/jcpe.70215","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the agreement between ultrasound-derived gingival sulcus depth (uGSD) and clinical probing depth (PD) at standardised mid-buccal sites as a proof-of-concept study.</p><p><strong>Materials and methods: </strong>Mid-buccal measurements were obtained from 963 sites in 69 participants (767 anterior, 127 premolars, 69 first molars) using an 18-MHz ultrasound transducer and a UNC-15 probe. uGSD was measured on B-mode images; reliability was assessed by two trained examiners. Agreement was evaluated using intra-class correlation coefficient (ICC), Bland-Altman analysis and mean absolute error (MAE). Generalised estimating equations and clustered ICCs accounted for within-patient clustering. Subgroups included PD strata, bleeding, tooth type, calculus, restorations (prosthetic crowns/orthodontic attachments) and smoking.</p><p><strong>Results: </strong>Ultrasound measurements showed high reliability (ICCs > 0.90). Agreement between uGSD and clinical PD was strong (ICC = 0.942; 95% CI: 0.935-0.949), with negligible mean difference (+0.023 mm) and low MAE (0.29 ± 0.32 mm). Subgroup ICCs ranged from 0.786 to 0.952; 85.0% of sites differed by ≤ 0.50 mm and 96.7% by ≤ 1.00 mm. Molar sites showed the highest MAE (0.38 mm) and slight underestimation (-0.123 mm).</p><p><strong>Conclusion: </strong>Intraoral ultrasonography showed high agreement with clinical PD at standardised mid-buccal sites in anterior teeth, premolars and first molars. It may serve as a non-invasive adjunct to conventional probing; however, broader studies are needed across complex sites and examiner experience levels.</p>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":" ","pages":""},"PeriodicalIF":8.3,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149194185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Local Factors and Implant‐Related Complications: A Population‐Sampled Cross‐Sectional Analysis","authors":"Erik Klepsland Mauland, Dagmar Fosså Bunæs, Stein‐Atle Lie, Anders Verket","doi":"10.1111/jcpe.70209","DOIUrl":"https://doi.org/10.1111/jcpe.70209","url":null,"abstract":"Aim To investigate the role of local factors and the association with peri‐implantitis and peri‐implant soft‐tissue dehiscence (PISTD). Materials and Methods A randomly selected sample of Norwegian patients who underwent implant therapy in 2014 was examined (242 patients; 732 implants). Clinical and radiographic parameters were recorded, including soft‐tissue phenotype, mucosal margin mobility, connection type, platform switching, emergence angle, implant location and presence of adjacent teeth. To account for clustering of implants within patients, mixed‐effects logistic regression models were applied. Results Mucosal margin mobility, bone‐level implants without platform switching, emergence angle &gt; 45°, anterior implant location and daily smoking were identified as significant risk indicators for peri‐implantitis. Thin soft‐tissue phenotype, mucosal margin mobility, absence of adjacent teeth, peri‐implantitis and external connection were detected as significant indicators for PISTD. Peri‐implantitis and PISTD were present in 8.7% and 25.0% of implants, respectively. Conclusions Local factors and soft‐tissue‐related parameters, many modifiable during treatment planning, were associated with peri‐implantitis and PISTD. Particular attention should be given to soft‐tissue phenotype, connection design, platform switching and prosthetic emergence angle. The relationship between systemic and local risk factors should be further investigated.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"11 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Serum Levels of Vitamin D and Periodontal Inflammation in Community‐Dwelling Older Japanese Adults: The Otassha Study”","authors":"","doi":"10.1111/jcpe.70212","DOIUrl":"https://doi.org/10.1111/jcpe.70212","url":null,"abstract":"","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"30 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shotgun Metagenomic Analysis Reveals Taxonomic and Functional Transitions in the Salivary Microbiome During Periodontal Disease Progression","authors":"Muhammed Manzoor,&nbsp;Jaakko Leskelä,&nbsp;Eija Könönen,&nbsp;Leo Lahti,&nbsp;Jukka Putaala,&nbsp;Pirkko J. Pussinen,&nbsp;Susanna Paju","doi":"10.1111/jcpe.70184","DOIUrl":"10.1111/jcpe.70184","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To characterise multi-kingdom salivary microbiome profiles across clinically defined periodontal states and identify stage-specific taxonomic and functional alterations using shotgun metagenomic sequencing.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>In this cross-sectional study, 204 adults (mean age 40.3 ± 7.6 years) from the SECRETO study (NCT01934725) underwent clinical and radiographic oral examinations and were classified into six periodontal groups: periodontal health, localised gingivitis, generalised gingivitis, gingivitis with pockets, mild periodontitis (Stages I–II) and severe periodontitis (Stages III–IV). Saliva samples were analysed using shotgun metagenomic sequencing to evaluate microbial diversity, taxonomic composition and functional pathways.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Beta diversity differed between periodontal health and the different disease states (Bray–Curtis: <i>p</i> = 0.049; Jaccard: <i>p</i> = 0.043). Gingivitis with pockets and severe periodontitis showed a significant enrichment of disease-associated species \u0000 <i>Porphyromonas gingivalis</i>\u0000 , \u0000 <i>Tannerella forsythia</i>\u0000 , \u0000 <i>Treponema denticola</i>\u0000 , \u0000 <i>Porphyromonas endodontalis</i>\u0000 , \u0000 <i>Fusobacterium nucleatum</i>\u0000 and \u0000 <i>Parvimonas micra</i>\u0000 . Among non-bacterial taxa, <i>Candida</i>, <i>Moineauvirus</i>, <i>Pyricularia</i> and <i>Roseolovirus</i> were the predominant genera. A composite metagenomic classifier showed high discriminative performance for gingivitis with pockets (AUC = 0.90; 95% CI: 0.770–1.000) and severe periodontitis (AUC = 0.865; 95% CI: 0.762–0.968).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Salivary multi-kingdom microbiome transitions closely reflect the progression of periodontal disease and provide promising biomarkers for identifying at-risk individuals.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 11","pages":"1650-1662"},"PeriodicalIF":8.3,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70184","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148701271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Palatal Donor-Site Healing and Patient-Reported Outcome Measures Following Chitosan and Injectable Platelet-Rich Fibrin-Enriched Chitosan Application Compared with Gelatine Sponge: A Three-Arm Randomised Controlled Clinical Trial","authors":"Ayse Ege Selman,&nbsp;Bahar Alkaya,&nbsp;Burcu Karaduman,&nbsp;Mustafa Ozcan,&nbsp;Mehmet Cenk Haytac","doi":"10.1111/jcpe.70194","DOIUrl":"10.1111/jcpe.70194","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To compare clinical outcomes and patient-reported outcome measures (PROMs) of palatal donor-site healing following the use of an absorbable gelatine sponge, a chitosan sponge or an injectable platelet-rich fibrin (i-PRF)-enriched chitosan sponge after free gingival graft harvesting.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>In this three-arm randomised controlled clinical study, a total of 68 patients were allocated to three groups: i-PRF + chitosan (<i>n</i> = 22), chitosan (<i>n</i> = 23) and gelatine sponge (control; <i>n</i> = 23). The primary outcome was the palatal early healing index (PEHI). Secondary outcomes included PROMs, namely postoperative pain, burning sensation and changes in dietary habits, which were evaluated using a visual analogue scale (VAS) at postoperative days 7, 14, 28 and 56. Bleeding and painkiller consumption were recorded daily. Colour match was assessed using VAS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Both chitosan-containing groups showed significantly higher PEHI scores, particularly on days 14 and 28, than the control group (<i>p</i> &lt; 0.001). At Day 14, the median PEHI scores were 8.0 (Q1–Q3: 7.0–8.0; 95% CI for the median: 7.0–8.0), 8.0 (Q1–Q3: 8.0–9.0; 95% CI: 8.0–9.0) and 9.0 (Q1–Q3:8.0–9.0; 95% CI: 8.0–9.0) in the control, chitosan and i-PRF-enriched chitosan groups, respectively. The i-PRF + chitosan group showed significantly lower pain and burning sensation during early healing and less changes on dietary habits on days 3 and 7 compared with the other groups (<i>p</i> &lt; 0.05). Bleeding and painkiller consumption were similar among groups (<i>p</i> &gt; 0.05). Both test groups showed significantly better colour match than the control group at days 14, 28 and 56 (<i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Within the limitations of the present study, chitosan improved early palatal wound healing, while the addition of i-PRF enhanced patient comfort. Both chitosan-containing approaches resulted in improved colour match compared with control. Nevertheless, further studies incorporating histological and biomolecular assessments of wound healing are needed to confirm these findings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 11","pages":"1702-1711"},"PeriodicalIF":8.3,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70194","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome Measures and ID-COSM Reporting Standards in Alveolar Ridge Augmentation: A Systematic Review of Clinical Trials","authors":"Khushboo Kalani,&nbsp;Hamoun Sabri,&nbsp;Maaham Lodhi,&nbsp;Pranav Kataria,&nbsp;Shivam Patel,&nbsp;Lucrezia Parma-Benfenati,&nbsp;Muhammad H. A. Saleh","doi":"10.1111/jcpe.70176","DOIUrl":"10.1111/jcpe.70176","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate outcome measures in clinical studies on alveolar ridge augmentation (ARA) and map them to the Implant Dentistry Core Outcome Set and Measurement (ID-COSM) framework and the Food and Drug Administration (FDA) terminology.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A systematic search was carried out across four databases through June 2025. Randomised and non-randomised clinical trials, prospective clinical studies, cohort studies and pilot clinical studies evaluating ARA performed before or simultaneously with implant placement were included. Extracted outcomes were mapped to ID-COSM domains, subdomains and specific outcomes, and all were classified into FDA-style outcome types. Risk of bias (RoB) was assessed using Domain 4 of RoB 2.0/ROBINS-I, and associations between RoB and completeness of outcome reporting were analysed with Spearman's rank correlation and Kruskal–Wallis tests (α = 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Four hundred and twenty-nine studies were included, predominantly randomised controlled trials (56.4%). Less than half of the studies fulfilled the mandatory ID-COSM domains (47.6%), and none reported all nine subdomains. For mandatory outcomes, surgical complications (52.7%) and implant placement feasibility (48.3%) were more frequently reported than bone dimensional changes (33.8%), and peri-implant bone stability was reported in only 11.0% of studies. For FDA categorisation, clinician-reported outcomes (86.3%) and biomarkers (87.7%) predominated, while patient-reported outcomes were reported in 31.9% of studies. Observer-reported or performance outcomes were completely absent. Lower risk of bias was associated with more complete reporting of outcomes across domains, subdomains and specific outcomes (<i>p</i> = 0.032, 0.017 and 0.009, respectively).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Outcome reporting for ARA trials is highly heterogeneous and poorly aligned with the standardised minimum outcomes recommended by ID-COSM and FDA categorisation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 11","pages":"1638-1649"},"PeriodicalIF":8.3,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70176","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Crestal Soft‐Tissue Augmentation Prior to or Simultaneously With Implant Placement on Peri‐Implant Tissue Dimensions: Histological Outcomes of an Experimental In Vivo Study","authors":"Yifan Zhang, Seo Young Park, Seung Ha Yoo, Soo‐Lim Bae, Aspasia Pachiou, Ui‐Won Jung, Daniel S. Thoma","doi":"10.1111/jcpe.70211","DOIUrl":"https://doi.org/10.1111/jcpe.70211","url":null,"abstract":"Aim To histologically assess the effect of the timing of soft‐tissue augmentation (prior to or simultaneously with implant placement) and the type of grafting material on peri‐implant soft‐tissue dimensions. Materials and Methods Mandibular molars (M1, M2, M3) were bilaterally extracted in six beagle dogs. Eight weeks after extraction, one mandibular side received primary soft‐tissue augmentation with an autogenous subepithelial connective tissue graft (SCTG) or a collagen‐based graft substitute (CG x1D), or no augmentation. At Week 16, implants were placed at these sites without flap. On the contralateral side, implants were placed with flap elevation simultaneously with SCTG or CG x1D, or no augmentation. Animals were sacrificed at Week 36. Histometric outcomes were analysed using linear mixed‐effects models with dog as a random intercept; significant six‐group effects were followed by Tukey‐adjusted pairwise comparisons. Results All six groups showed crestal bone remodelling apical to the implant shoulder. The AFL group consistently exhibited the greatest peri‐implant soft‐tissue dimensions. Significant overall group effects were identified for lingual fBIC‐M ( <jats:italic>F</jats:italic> = 3.58, <jats:italic>p</jats:italic> = 0.014) and lingual IS‐M ( <jats:italic>F</jats:italic> = 4.46, <jats:italic>p</jats:italic> = 0.005), with AFL significantly exceeding FL and FC at both outcomes. SCTG sites showed significantly greater lingual fBIC‐M and IS‐M than collagen substitute sites ( <jats:italic>p</jats:italic> = 0.013 and <jats:italic>p</jats:italic> = 0.012, respectively). Conclusions Prior soft‐tissue augmentation with an autogenous graft before flapless implant placement (AFL) resulted in more favourable peri‐implant soft‐tissue dimensions. Both autogenous grafts and collagen substitutes contribute to soft‐tissue volume gains around implants. Clinical trials are warranted to confirm these findings.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"10 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Artificial Intelligence Match Human Expertise in Long-Term Periodontal Prognosis? A Comparative Accuracy Study","authors":"Pablo Antonio López-Galindo,&nbsp;Giuseppe Troiano,&nbsp;Matteo Serroni,&nbsp;Debora R. Dias,&nbsp;Pasquale Santamaría,&nbsp;Luigi Nibali,&nbsp;Gustavo Avila-Ortiz,&nbsp;Andrea Ravidà","doi":"10.1111/jcpe.70191","DOIUrl":"10.1111/jcpe.70191","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To compare the prognostic performance of an artificial intelligence (AI) model with that of experienced clinicians in predicting tooth loss over a 10-year period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>An AI model trained on structured clinical and radiographic data was compared with 12 periodontists and 11 general dentists (GDs), who independently assigned prognostic scores (0–10 scale) to 300 teeth with known 10-year outcomes. AI and clinician performance were evaluated under a fixed threshold and group-specific optimal thresholds. Accuracy, sensitivity, specificity, predictive values, area under the receiver operating characteristic curve and calibration were used for comparison.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Using the fixed threshold (score &gt; 5 = survival), clinicians achieved higher overall accuracy than AI (75.6% periodontists, 74.9% GDs, 69.2% AI; <i>p</i> &lt; 0.05), with sensitivity low and comparable across groups (14.7%–22.7%). Using group-specific optimal thresholds, AI achieved the highest accuracy for all-cause tooth loss (67.5%) and performed comparably to GDs for periodontitis-related tooth loss (76.2% vs. 76.3%). Calibration was substantially worse for AI (Brier score 0.247) than for periodontists and GDs (0.171, 0.170). Individually, AI performance overlapped with that of several clinicians.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Clinicians outperformed AI under a fixed threshold, but AI performance was comparable to clinicians using optimal thresholds, situating AI within the range of experienced clinicians despite modest overall predictive ability.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 11","pages":"1712-1721"},"PeriodicalIF":8.3,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70191","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148768315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontal Status and the Risk of All-Cause Dementia, Alzheimer's Disease and Vascular Dementia in a Community: The Hisayama Study","authors":"Michiko Furuta,&nbsp;Tomoyuki Ohara,&nbsp;Satoko Sakata,&nbsp;Mao Shibata,&nbsp;Emi Oishi,&nbsp;Yoshihiko Furuta,&nbsp;Shinya Kageyama,&nbsp;Mikari Asakawa,&nbsp;Yoshihiro Shimazaki,&nbsp;Toru Takeshita,&nbsp;Toshiharu Ninomiya","doi":"10.1111/jcpe.70185","DOIUrl":"10.1111/jcpe.70185","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study examined the associations of periodontal status with incident dementia and its subtypes in a Japanese community.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>The 1396 participants aged ≥ 60 years without dementia were followed for 10 years. Periodontal status at baseline and 5 years was assessed using mean probing pocket depth (PPD), clinical attachment level (CAL) and percentage of bleeding on probing (%BOP), categorized into quartiles. Cox proportional hazards and time-varying Cox models were used.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>During follow-up, 267 participants developed dementia; 194 and 51 had Alzheimer's disease (AD) and vascular dementia (VaD), respectively. Compared with the lowest quartile, the highest quartiles of PPD, CAL and %BOP at baseline were associated with increased dementia risk (hazard ratio 1.72 [95% confidence interval 1.18–2.46], 1.59 [1.07–2.38] and 1.56 [1.09–2.22], respectively, all <i>p</i> for trend &lt; 0.05). Elevated %BOP was associated with AD risk (<i>p</i> for trend = 0.023). Higher PPD tended to be associated with VaD (<i>p</i> for trend = 0.076). Similar associations for all-cause dementia were observed in time-varying Cox analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Poor periodontal status was associated with dementia in older Japanese adults. These findings highlight the potential public health importance of preventing periodontitis to reduce the risk of dementia.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 11","pages":"1663-1672"},"PeriodicalIF":8.3,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70185","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148754575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}