Journal of Clinical Periodontology最新文献

{"title":"Operative Times, Costs and Patient‐Related Outcome Measures in Vertical Ridge Augmentation With Customised Reinforced PTFE Mesh Versus CAD/CAM Titanium Mesh: Secondary Analysis of a Randomised Clinical Trial","authors":"Alessandro Cucchi, Sofia Bettini, Lucia Tedeschi, Debora Franceschi, Istvan Urban, Antonino Fiorino, Giuseppe Corinaldesi","doi":"10.1111/jcpe.14185","DOIUrl":"https://doi.org/10.1111/jcpe.14185","url":null,"abstract":"AimThis secondary analysis of a randomised clinical trial aimed to investigate vertical ridge augmentation (VRA) by comparing complication rates (primary outcome), times, costs and patient‐reported outcome measures (PROMs) between customised Ti‐reinforced PTFE mesh and customised CAD/CAM titanium mesh.Materials and MethodsPatients with vertical bone defects were randomly assigned to alveolar bone augmentation using either Ti‐PTFE mesh or Ti mesh (T0). After 6–9 months, barriers were removed, and computer‐guided surgery was performed to place implants in the augmented sites (T1). Complications, times, costs and PROMs (anxiety, pain, anti‐inflammatory drug dosage, limitations in daily functions) were assessed and analysed.ResultsForty‐eight of 50 patients completed the bone augmentation surgery as per protocol. The estimated difference in healing complications was −0.04% (CI: −0.22 to 0.13), confirming the non‐inferiority of Ti meshes to PTFE meshes. The estimated differences were −3.50 min (CI: −23.49 to 16.49) for total operative time (<jats:italic>p</jats:italic> = 0.688); €17.37 (−77.25 to 111.99) for costs (<jats:italic>p</jats:italic> = 0.130); −0.17 (CI: −0.80 to 0.47) for anti‐inflammatory drug usage (<jats:italic>p</jats:italic> = 0.299); 0.56 (CI: −1.97 to 0.85) for pain levels (<jats:italic>p</jats:italic> = 0.565); and −0.13 (CI: −0.61 to 0.36) for limitations in daily functions (<jats:italic>p</jats:italic> = 0.528), on the day after surgery.ConclusionOutcomes were favourable, which encourage the use of both medical devices with low complication rates and both digital approaches, resulting in favourable operative times and PROMs.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"97 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial Markers for Diagnosis and Risk Assessment for Periodontal Diseases: A Systematic Literature Search and Narrative Synthesis","authors":"Nagihan Bostanci, Daniel Manoil, Wannes Van Holm, Georgios N. Belibasakis, Wim Teughels","doi":"10.1111/jcpe.14183","DOIUrl":"https://doi.org/10.1111/jcpe.14183","url":null,"abstract":"AimTo examine the accuracy of microbiological biomarkers in diagnosing periodontal diseases, specifically addressing three focus questions: (FQ1) distinguishing health from disease; (FQ2) predicting disease progression; and (FQ3) assessing treatment outcomes.Materials and MethodsA PRISMA‐guided search in MEDLINE, EMBAS and WEB OF SCIENCE included cross‐sectional and longitudinal studies (e.g., randomised controlled trials, cohort studies) with ≥ 20 participants per group. Eligible studies involved individuals diagnosed with periodontal health, gingivitis or periodontitis, based on well‐defined clinical criteria, and utilised microbiological analyses of oral fluids and/or dental plaque. Diagnostic accuracy had to be evaluated using sensitivity, specificity or area under the receiver operating characteristic (ROC) curve (AUC), or alternatively, data for their computation had to be provided.ResultsThirty‐one studies were included, mostly cross‐sectional or case–control, with significant variability in sampling sites, microbial analyses and diagnostic definitions, complicating direct comparisons. Frequently investigated biomarkers included <jats:styled-content style=\"fixed-case\"><jats:italic>Aggregatibacter actinomycetemcomitans</jats:italic></jats:styled-content> (JP2 genotype), <jats:styled-content style=\"fixed-case\"><jats:italic>Porphyromonas gingivalis</jats:italic></jats:styled-content>, <jats:styled-content style=\"fixed-case\"><jats:italic>Tannerella forsythia</jats:italic></jats:styled-content> and <jats:styled-content style=\"fixed-case\"><jats:italic>Treponema denticola</jats:italic></jats:styled-content>. The highest diagnostic accuracy (AUC &gt; 0.95) was achieved through composite microbiome‐based metrics such as the subgingival microbial dysbiosis index. However, methodological heterogeneity and inconsistent criteria limited reliability.ConclusionAlthough microbiological biomarkers hold promise for periodontal disease diagnostics and monitoring, current evidence is insufficient for clinical implementation. Future research should standardise methodologies, sampling protocols and diagnostic criteria to ensure robust validation and facilitate integration into precision dentistry.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"89 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosomes Derived From Human Gingival Mesenchymal Stem Cells Induce Metabolic Reprogramming of Inflammatory Macrophages","authors":"Jialu Wang, Yingzhe Hu, Zhiguo Wang, Chun Fan, Ye Liu, Yutong Xie, Lubin Liu, Jingshu Yang, Quanchen Xu","doi":"10.1111/jcpe.14184","DOIUrl":"https://doi.org/10.1111/jcpe.14184","url":null,"abstract":"AimTo investigate the influence and mechanism of exosomes derived from human gingival mesenchymal stem cells (GMSC‐Exo) regulating macrophage polarisation through metabolic reprogramming.Materials and MethodsHuman acute monocytic leukaemia cells (THP‐1)‐derived macrophages were treated with GMSC‐Exo or <jats:styled-content style=\"fixed-case\"><jats:italic>Porphyromonas gingivalis</jats:italic></jats:styled-content> lipopolysaccharide (<jats:italic>P.g</jats:italic>‐LPS) in vitro. Metabolic inhibitors were used to study the role of metabolic reprogramming in GMSC‐Exo‐induced polarisation, while the hypoxia‐inducible factor‐1 alpha (HIF‐1α) modulators were employed to explore the HIF‐1α signalling pathway's impact on macrophage metabolic reprogramming. The impact of GMSC‐Exo on periodontitis and macrophage metabolism was assessed using a rat model in vivo.ResultsIn vitro experiments confirmed that GMSC‐Exo promoted the polarisation of macrophages from pro‐inflammatory M1 type (classically activated) to anti‐inflammatory M2 type (alternatively activated) by promoting metabolic reprogramming (glycolysis to oxidative phosphorylation). In this process, the activation of the HIF‐1α signalling pathway was inhibited. In vivo experiments revealed that GMSC‐Exo could regulate the inflammatory microenvironment of periodontal tissue and the metabolic pattern of macrophages.ConclusionBy inhibiting the activation of HIF‐1α signalling pathway, GMSC‐Exo trigger metabolic reprogramming in macrophages, thereby regulating the macrophage transformation from pro‐inflammatory M1 phenotype to anti‐inflammatory M2 phenotype. This change enhances the local inflammatory environment, aiding tissue repair and regeneration.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"10 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Randomized Controlled Study on the Treatment of Isolated Interdental Intrabony Defects Using the Modified Minimally Invasive Surgical Technique With or Without a Collagen-Enriched Bovine-Derived Xenograft: A 2-Year Analysis.","authors":"Yuzhe Sun,Haidong Zhang,Churen Zhang,Xiaochi Chang,Hongqiao Zhao,Xiangyu Sun,Pierpaolo Cortellini,Kaining Liu,Jianxia Hou","doi":"10.1111/jcpe.14178","DOIUrl":"https://doi.org/10.1111/jcpe.14178","url":null,"abstract":"AIMThis study aimed to evaluate the efficacy of the modified minimally invasive surgical technique (M-MIST) combined with a collagen-enriched bovine-derived xenograft (CEBDX) for the treatment of isolated interdental intrabony defects.MATERIALS AND METHODSThis is a randomized controlled trial including 40 isolated interdental intrabony defects in 40 patients. The test group received M-MIST and CEBDX, and the control group received M-MIST alone. Re-evaluations were performed 1 and 2 years after surgery, with probing depth (PD) and clinical attachment level (CAL) measured at the buccal/labial and lingual/palatal sides of the defects as at baseline. Periapical radiographs and CBCT were also performed to evaluate the radiographic bone changes of the defects.RESULTSThirty-eight defects were evaluated at the 1- and 2-year follow-ups, and both groups showed statistically significant improvements in PD, CAL and radiographic bone volume. The test group exhibited increased PD reduction (3.95 ± 1.39 mm vs. 2.95 ± 1.51 mm, p = 0.041) and CAL gain (3.58 vs. 2.53 mm on average, p = 0.043) at the buccal side of the defects. No difference was found at the lingual side. A significantly greater radiographic bone volume gain (17.77 ± 11.44 mm3 vs. 8.63 ± 7.10 mm3, p = 0.011) was found in the test group at the 2-year follow-up.CONCLUSIONSM-MIST was effective both alone and with CEBDX. The addition of CEBDX significantly improved radiographic bone volume gain and PD reduction, and CAL gain at the buccal side of the defects.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"32 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential Response to Non-Surgical Periodontal Therapy Between Intrabony and Suprabony Defects: A Retrospective Analysis.","authors":"Alessandro Cuozzo,Mishika Arora,Lorenzo Marini,Joshua Hurley,Zainab Malaki,Jing Kang,Luca Ramaglia,Luigi Nibali","doi":"10.1111/jcpe.14181","DOIUrl":"https://doi.org/10.1111/jcpe.14181","url":null,"abstract":"AIMTo assess the clinical response to Non-Surgical Periodontal Therapy (NSPT) between suprabony and intrabony defects.MATERIALS AND METHODSTotally 200 NSPT patients' records from the King's College London-Oral, Dental and Craniofacial Biobank were included. Periapical radiographs of sites with Periodontal Probing Depth (PPD) > 4 mm were assessed. Changes in periodontal measurements between baseline and three-month re-evaluation were examined and compared across suprabony and intrabony sites. Multilevel analysis was carried out to assess the relative contribution of site-, tooth-, patient- and treatment-related factors on the clinical outcomes.RESULTSAlthough intrabony defects showed higher PPD reduction after NSPT compared with suprabony defects, this was a function of initial deeper PPD. In fact, suprabony defects outperformed intrabony defects for 'pocket closure' at every initial PPD threshold and overall were 2.60 times more likely to achieve 'pocket closure'. Defect morphology was one of several factors affecting treatment outcomes. The relative contribution to 'pocket closure' was 64.9% for site-, 26.1% for patient-, 9.0% for tooth- and 1% for treatment-related factors.CONCLUSIONBone defect morphology influences clinical outcome of NSPT, with suprabony defects being twice as likely to achieve pocket closure and resulting in 0.6 mm more PPD reduction compared with intrabony defects.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"40 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144097742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increasing Serum Vitamin D Levels Reduces Gingival Crevicular Fluid Matrix Metalloproteinase-9 Levels in Periodontal Health and Diseases.","authors":"Vusal Gurbanov,Ayla Öztürk,Fatma Doğruel,Hatice Saraçoğlu,Cevat Yazıcı","doi":"10.1111/jcpe.14175","DOIUrl":"https://doi.org/10.1111/jcpe.14175","url":null,"abstract":"AIMSTo investigate whether restoring serum vitamin D levels in a population requiring supplementation affects matrix metalloproteinase-9 (MMP-9) levels in the gingival crevicular fluid (GCF) of individuals with periodontal health, gingivitis and periodontitis.MATERIALS AND METHODSThis prospective cohort study enrolled 101 participants with vitamin D deficiency, including those with periodontitis (34) and gingivitis (34) and healthy individuals (33). The periodontal status was evaluated using radiographic and clinical assessments of probing depth, clinical attachment loss, gingival index and plaque index. The analysis of MMP-9 levels in the GCF collected from the same dental sites was performed at baseline and 1 month post supplementation.RESULTSAfter 1 month of vitamin D supplementation, a significant decrease in GCF MMP-9 levels was observed across all groups, with the most notable reduction observed in the periodontitis group. The healthy group exhibited the highest percentage reduction at 47%. Linear regression analysis confirmed that changes in vitamin D levels and pocket depth influenced MMP-9 alterations in the GCF.CONCLUSIONSRestoration of vitamin D levels in vitamin D-deficient patients to the recommended average level (30 ng/mL), according to established guidelines, led to decreased MMP-9 levels in individuals with different periodontal statuses (healthy, gingivitis or periodontitis), potentially mitigating periodontal risks.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"14 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Radiological Markers of Periodontal Status and Risk of Cognitive Decline and Incident Dementia.","authors":"Sam Asher,Anna Liisa Suominen,Ruth Stephen,Tiia Ngandu,Seppo Koskinen,Alina Solomon","doi":"10.1111/jcpe.14173","DOIUrl":"https://doi.org/10.1111/jcpe.14173","url":null,"abstract":"AIMThere is evidence linking tooth loss with dementia; however, similar findings for periodontitis are inconclusive.MATERIAL AND METHODSWe conducted cross-sectional (N = 4046) and longitudinal analyses (N = 2769) on data from the Health 2000 and 2011 surveys for establishing any associations of periodontal health with baseline cognition, 11-year risk of cognitive decline and 15-year risk of incident dementia (N = 4073; study period from 1 September 2000 to 31 December 2015). Periodontal health was assessed via multiple clinical and radiographic markers. Based on periodontal pocket depths (PPDs), we defined periodontitis as moderate or severe. Cognitive tests at baseline and follow-up were administered, and dementia diagnoses until 2015 were retrieved from health registers. Analyses included logistic and Cox proportional regression, accounting for reverse causality.RESULTSCross-sectionally, moderate periodontitis was associated with lower overall cognition (OR = 1.19:1.02-1.40), verbal fluency (OR = 1.16:1.00-1.35) and immediate recall (OR = 1.22:1.04-1.42); PPD with lower overall cognition (OR = 1.22:1.04-1.43) and verbal fluency (OR = 1.18:1.02-1.38); and bleeding on probing (BOP) with verbal fluency (OR = 1.26:1.07-1.48) and immediate recall (OR = 1.22:1.02-1.45). Longitudinally, moderate periodontitis was associated with the risk of decline in immediate recall (OR = 1.29:1.04-1.60) and severe periodontitis with verbal fluency (OR = 1.46:1.01-2.11); PPD with immediate recall (OR = 1.23:1.00-1.53); and BOP with verbal fluency (OR = 1.31:1.05-1.63). Edentulism was associated with multiple cognitive tests (OR range:1.71-1.88). No associations with the risk of incident dementia were observed.CONCLUSIONSPoor periodontal health may increase the risk of cognitive decline. Future studies into the underlying mechanisms are warranted.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"55 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"E-Poster | Research Presentation","authors":"","doi":"10.1111/jcpe.14160","DOIUrl":"https://doi.org/10.1111/jcpe.14160","url":null,"abstract":"","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 S28","pages":"162-377"},"PeriodicalIF":5.8,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143939479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Prolonged Fasting on the Oral Microbiome in Patients With Metabolic Syndrome: An Exploratory Secondary Analysis.","authors":"C L Pappe,S Kleine Bardenhorst,K Prior,N Steckhan,A Michalsen,B Ehmke,H Dommisch,D Hagenfeld","doi":"10.1111/jcpe.14171","DOIUrl":"https://doi.org/10.1111/jcpe.14171","url":null,"abstract":"AIMTo evaluate the effect of prolonged fasting on the oral microbiome in patients with metabolic syndrome (MetS).MATERIALS AND METHODSThis follow-up study evaluated changes in the oral microbiome in a sub-cohort of 42 patients with MetS during prolonged fasting. Periodontal parameters such as bleeding on probing (BOP), plaque index (PI) and gingival crevicular fluid (GCF) measured in Periotron units (PU) as well as supra- and subgingival plaque samples were taken at baseline (T1), after 5-10 days of prolonged fasting (T2) and at 4-5-month follow-up (T3). Sequencing of the V4 hypervariable region of the 16S rRNA gene was performed to analyse the microbiome composition.RESULTSSignificant reductions were observed in BOP: 36.4% ± 18.2% to 30.4% ± 15.6% (p = 0.01), PI: 66.9% ± 19.5% to 58.8% ± 23.4% (p < 0.01) and GCF: 83.6 ± 27.8 PU to 67.9 ± 30.3 PU (p < 0.01) post fasting. Microbiome α- and β-diversity did not change significantly. However, significant changes in specific bacterial genera were noted: Lachnospiraceae [G-3] increased only in subgingival samples; Eikenella and Peptostreptococcaceae [XI][G-7] increased; while Mitsuokella and Atopobium decreased in both sub- and supra-gingival samples.CONCLUSIONWithin the constraints of this analysis, prolonged fasting was found to be associated with reduced periodontal inflammation and selected shifts in the oral microbial composition. Larger controlled trials are needed to confirm these exploratory findings and determine their clinical relevance.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"96 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143945178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EuroPerio11 Author Index","authors":"","doi":"10.1111/jcpe.14163","DOIUrl":"https://doi.org/10.1111/jcpe.14163","url":null,"abstract":"","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 S28","pages":"581-608"},"PeriodicalIF":5.8,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143939481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}