Journal of Clinical Periodontology最新文献

Familial Patterns of Oral–Gut Dysbiosis and Systemic Markers in Periodontitis 牙周炎患者口腔-肠道生态失调和全身标志物的家族性模式

IF 6.7 1区医学

Journal of Clinical Periodontology Pub Date : 2025-10-09 DOI: 10.1111/jcpe.70047

Hélvis E. S. Paz, Mabelle F. Monteiro, Camila S. Stolf, Cássia F. Araújo, Angelika Silbereisen, Mauro P. Santamaria, Nagihan Bostanci, Renato C. V. Casarin

{"title":"Familial Patterns of Oral–Gut Dysbiosis and Systemic Markers in Periodontitis","authors":"Hélvis E. S. Paz, Mabelle F. Monteiro, Camila S. Stolf, Cássia F. Araújo, Angelika Silbereisen, Mauro P. Santamaria, Nagihan Bostanci, Renato C. V. Casarin","doi":"10.1111/jcpe.70047","DOIUrl":"https://doi.org/10.1111/jcpe.70047","url":null,"abstract":"AimTo investigate whether periodontitis in parents is associated with differences in the faecal microbiome and systemic markers in both themselves and their children.MethodsEighty participants were divided into four groups (n = 20): parents with periodontitis (PP); healthy parents (PC); and their respective children (CP, CC). Clinical periodontal parameters were recorded. Saliva and faecal bacterial DNA were analysed via 16S rRNA sequencing. Salivary lactoferrin, faecal calprotectin, gingival crevicular fluid cytokines (IFN‐γ, IL‐10, IL‐17, IL‐1β, IL‐4, TNF‐α) and urinary intestinal permeability markers (claudin‐2, ‐3, ‐4, haptoglobin) were quantified.ResultsParents with periodontitis showed distinct faecal microbiota profiles, which were mirrored in their children and significantly differed from controls. Claudin‐2 levels were elevated in both PP and CP groups (p < 0.05) and positively correlated with the oral dysbiosis index and the faecal Firmicutes/Bacteroidetes ratio.ConclusionsParental periodontal health appears to influence the faecal microbiome and systemic markers in the offspring. These findings highlight a potential pathway for oral–gut microbial transmission and its relevance to systemic health, warranting further investigation.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"62 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterising the Periodontal Granulation Tissue Using scRNAseq 用scRNAseq表征牙周肉芽组织

IF 6.7 1区医学

Journal of Clinical Periodontology Pub Date : 2025-10-07 DOI: 10.1111/jcpe.70048

Wentao Zhu, Kathy Fung, Pawan Dhami, Paul Sharpe, Jan Krivanek, Luigi Nibali, Cheng Zhang, Vitor C. M. Neves

{"title":"Characterising the Periodontal Granulation Tissue Using scRNAseq","authors":"Wentao Zhu, Kathy Fung, Pawan Dhami, Paul Sharpe, Jan Krivanek, Luigi Nibali, Cheng Zhang, Vitor C. M. Neves","doi":"10.1111/jcpe.70048","DOIUrl":"https://doi.org/10.1111/jcpe.70048","url":null,"abstract":"AimTo investigate the cellular composition and molecular mechanisms of periodontal granulation tissue formation using single‐cell RNA sequencing (scRNA‐seq), aiming to enhance the understanding of periodontal disease pathogenesis and identify potential targets for regenerative therapies.Materials and MethodsGranulation tissue samples were collected from patients undergoing periodontal surgery (n = 3). Fresh tissues were processed into single‐cell suspensions and subjected to scRNA‐seq. The data were integrated and compared with existing datasets from healthy gingiva and periodontal ligament. Computational analyses were performed and validated through immunofluorescence staining.ResultsTen distinct cell clusters were identified across the samples. Granulation tissue exhibited a higher abundance of immune cells compared to healthy tissues. A novel endothelial cell subpopulation, exclusive to granulation tissue, was discovered and characterised by NOTCH3 expression and involvement in ossification pathways. Additionally, granulation tissue fibroblast subpopulations demonstrated a progenitor‐like state, characterised by extracellular matrix reorganisation and low differentiation, similar to cancer‐associated fibroblasts.ConclusionThis study identified a novel endothelial subpopulation offering new insights into the disease's pathogenesis and presenting potential targets for regenerative therapies. These findings will help advance the understanding of periodontal disease granulation tissue formation and provide information for the development of materials to modulate specific cellular pathways to improve periodontal disease management.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"30 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Barriers to Periodontal Treatment Adherence in Patients With Periodontitis to Inform Development of a Digital Companion: A Qualitative Study. 探索牙周炎患者牙周治疗依从性的障碍，为数字伴侣的发展提供信息：一项定性研究。

IF 6.7 1区医学

Journal of Clinical Periodontology Pub Date : 2025-10-07 DOI: 10.1111/jcpe.70044

Lina Weinert,Nihad El Sayed,Michel Wensing,Bettina Dannewitz,Stefan Listl

{"title":"Exploring Barriers to Periodontal Treatment Adherence in Patients With Periodontitis to Inform Development of a Digital Companion: A Qualitative Study.","authors":"Lina Weinert,Nihad El Sayed,Michel Wensing,Bettina Dannewitz,Stefan Listl","doi":"10.1111/jcpe.70044","DOIUrl":"https://doi.org/10.1111/jcpe.70044","url":null,"abstract":"AIMThe objectives of this study were to gain a comprehensive understanding of patients' barriers to adherence to periodontal treatment and to derive intervention functions for a digital companion to support them through their therapy journey.MATERIALS AND METHODSA qualitative study incorporating patient and expert interviews was designed. Data were analysed using thematic analysis. Barriers to therapy adherence and functions for a digital intervention were synthesised with the help of the Capability, Opportunity and Motivation behaviour change model.RESULTSBarriers related to periodontal therapy are a lack of awareness of the patients' own responsibility and prioritisation of individual oral health, lack of time to both instruct as well as learn and perform better oral hygiene and lack of knowledge about disease characteristics and ideal habits. Participants expected that a digital intervention should incorporate personalised and comprehensive educational material, possibilities to visually document progress, simple descriptions of oral hygiene tasks, reminders and the inclusion of prompts for self-reflection.CONCLUSIONWhile a digital health companion has the potential to address the aforementioned barriers, future research should also aim to develop strategies to focus on health systems barriers (e.g., financing and workforce arrangements) as these can influence patient engagement and adherence.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"49 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Subgingival Host-Microbial Landscape in Mothers With Periodontitis and Their At-Risk Offspring. 牙周炎母亲及其危险后代的龈下宿主-微生物景观。

IF 6.7 1区医学

Journal of Clinical Periodontology Pub Date : 2025-10-02 DOI: 10.1111/jcpe.70045

Hélvis E S Paz,Camila S Stolf,Kai Bao,Mabelle F Monteiro,Lucas M Carvalho,Angelika Silbereisen,Georgios N Belibasakis,Renato C V Casarin,Nagihan Bostanci

{"title":"The Subgingival Host-Microbial Landscape in Mothers With Periodontitis and Their At-Risk Offspring.","authors":"Hélvis E S Paz,Camila S Stolf,Kai Bao,Mabelle F Monteiro,Lucas M Carvalho,Angelika Silbereisen,Georgios N Belibasakis,Renato C V Casarin,Nagihan Bostanci","doi":"10.1111/jcpe.70045","DOIUrl":"https://doi.org/10.1111/jcpe.70045","url":null,"abstract":"AIMTo evaluate the subgingival proteome and microbiome of mothers with periodontitis and their offspring, thereby assessing signatures of periodontal diseases.METHODSForty participants in four groups were included: mothers with periodontitis and their offspring, as well as periodontally healthy mothers and their offspring. Periodontal clinical parameters were assessed. Gingival crevicular fluid (GCF) and subgingival biofilm were collected from the same sites. Proteome from GCF was investigated by liquid chromatography-tandem mass spectrometry with data-independent acquisition (DIA-PASEF). Bacterial DNA from subgingival biofilms was sequenced using the 16S rRNA gene for taxonomy assignment.RESULTSOverall, 6147 bacterial and human proteins (≥ 2 peptides) were quantified. Despite the absence of attachment loss, the offspring of mothers with periodontitis presented with similar proteotypes as their mothers, characterised by up-regulation of inflammatory response cascades and down-regulation of epithelial barrier proteins. They also displayed higher colonisation patterns by periodontopathogens while presenting with increased expression of bacterial virulence proteins compared with controls.CONCLUSIONThe study showed that the maternal periodontal microbiome and proteome associate with those of the offspring and relate to maternal periodontal status. These early ecological events may potentially promote offspring's susceptibility to dysbiosis and may predispose them to periodontitis.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to ‘Bone Regeneration After Sinus Floor Elevation in an Intact Sinus or a Sinus With Prior Large Membrane Perforation: A Preclinical Study Using a Rabbit Sinus Model’ “完整鼻窦底抬高或先前有大膜穿孔的鼻窦骨再生的纠正：兔鼻窦模型的临床前研究”

IF 6.7 1区医学

Journal of Clinical Periodontology Pub Date : 2025-09-29 DOI: 10.1111/jcpe.70014

引用次数: 0

The Association of Periodontitis With Risk of Prevalent and Incident Metabolic Syndrome. 牙周炎与流行和偶发代谢综合征风险的关系。

IF 6.7 1区医学

Journal of Clinical Periodontology Pub Date : 2025-09-23 DOI: 10.1111/jcpe.70042

Jenni Kinnunen,Kari Koponen,Oleg Kambur,Muhammed Manzoor,Katariina Aarnisalo,Verneri Nissilä,Satu Männistö,Veikko Salomaa,Pekka Jousilahti,Eija Könönen,Ulvi Kahraman Gürsoy,Aki S Havulinna,Aino Salminen,Pirkko Pussinen

{"title":"The Association of Periodontitis With Risk of Prevalent and Incident Metabolic Syndrome.","authors":"Jenni Kinnunen,Kari Koponen,Oleg Kambur,Muhammed Manzoor,Katariina Aarnisalo,Verneri Nissilä,Satu Männistö,Veikko Salomaa,Pekka Jousilahti,Eija Könönen,Ulvi Kahraman Gürsoy,Aki S Havulinna,Aino Salminen,Pirkko Pussinen","doi":"10.1111/jcpe.70042","DOIUrl":"https://doi.org/10.1111/jcpe.70042","url":null,"abstract":"AIMTo investigate whether periodontitis is associated with prevalent and incident metabolic syndrome (MetS).MATERIALS AND METHODSThe baseline study included 4183 individuals from a population-based survey (DILGOM) in 2007 and follow-up of 1047 participants with clinical re-examination in 2014. The risk of periodontitis was assessed with saliva biomarkers using a validated, three-group cumulative risk score for periodontitis (CRS I, II and III).RESULTSIn fully adjusted models, CRS III was associated with prevalent MetS (OR: 1.35, 95% CI [1.11-1.65]), high waist circumference (1.55 95% CI [1.26-1.91]), high blood pressure (1.29 95% CI [1.05-1.59]) and the number of MetS components (β: 0.18, 95% CI [0.06-0.30]). Among participants without MetS at baseline (n = 618), 128 (20.7%) developed MetS during follow-up. In the fully adjusted model, CRS III trended positively with incident MetS (RR: 1.55, 95% CI [ 0.96-2.51]) in the whole population and had a significant positive association in women (2.06, 95% CI [1.08-3.94]), and in non-smokers (1.78, 95% CI [1.01-3.14]). The risk between CRS and incident MetS was mediated via systemic inflammation.CONCLUSIONPeriodontitis is associated with an increased risk of having metabolic syndrome and, in particular, clearly with the number of MetS components: abdominal obesity, hyperglycaemia and hypertension. Systemic inflammation may elucidate the observed higher risk of incident MetS.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"17 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145127023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut Microbial Metabolite Butyrate Regulates Treg/Th17 Cell Balance to Alleviate Diabetic Periodontitis 肠道微生物代谢物丁酸调节Treg/Th17细胞平衡减轻糖尿病牙周炎

IF 6.7 1区医学

Journal of Clinical Periodontology Pub Date : 2025-09-22 DOI: 10.1111/jcpe.70041

Wenying Yang, Yanling Zhang, Yifan Xu, Jing Diao, Shuguo Zheng, Chao Yuan

{"title":"Gut Microbial Metabolite Butyrate Regulates Treg/Th17 Cell Balance to Alleviate Diabetic Periodontitis","authors":"Wenying Yang, Yanling Zhang, Yifan Xu, Jing Diao, Shuguo Zheng, Chao Yuan","doi":"10.1111/jcpe.70041","DOIUrl":"https://doi.org/10.1111/jcpe.70041","url":null,"abstract":"AimTo investigate whether the gut microbiota–derived metabolite butyrate alleviates the progression of diabetic periodontitis by modulating the Treg/Th17 cell balance.Materials and MethodsA diabetic periodontitis mouse model was established to assess alveolar bone loss, Treg/Th17 cell subsets, colonic histopathology, faecal microbiota composition and short‐chain fatty acid (SCFA) levels. To investigate microbial causality and therapeutic potential, faecal microbiota transplantation (FMT) and butyrate supplementation were conducted.ResultsMice with diabetic periodontitis exhibited a disrupted Treg/Th17 balance accompanied by colonic epithelial damage and a decreased abundance of SCFA‐producing gut microbiota. Faecal SCFA levels showed a downward trend, although the reduction in butyrate was not significant. FMT from diabetic periodontitis mice aggravated periodontal destruction, impaired the colonic mucus barrier and further disturbed Treg/Th17 homeostasis in the recipient mice. These effects were associated with a decrease in SCFA‐producing bacteria and faecal butyrate levels. Moreover, butyrate supplementation significantly alleviated periodontal destruction and restored the Treg/Th17 balance.ConclusionGut microbiota dysbiosis contributes to diabetic periodontitis progression through disruption of the Treg/Th17 balance, whereas butyrate, as an immunomodulatory SCFA, may alleviate periodontal tissue destruction by restoring this balance.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"30 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145116483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cost Effectiveness of Two Short Implants Versus One Short Implant With a Cantilever in the Posterior Region: 7.5-Year Follow-Up of a Randomised Controlled Trial. 两个短种植体与一个短种植体的成本效益与后区悬臂：7.5年随访的随机对照试验。

IF 6.7 1区医学

Journal of Clinical Periodontology Pub Date : 2025-09-21 DOI: 10.1111/jcpe.70039

Franz J Strauss,Lucia Schiavon,Nadja Naenni,Riccardo D Kraus,Gustavo Sáenz-Ravello,Nicolas Müller,Ronald E Jung,Daniel S Thoma

{"title":"Cost Effectiveness of Two Short Implants Versus One Short Implant With a Cantilever in the Posterior Region: 7.5-Year Follow-Up of a Randomised Controlled Trial.","authors":"Franz J Strauss,Lucia Schiavon,Nadja Naenni,Riccardo D Kraus,Gustavo Sáenz-Ravello,Nicolas Müller,Ronald E Jung,Daniel S Thoma","doi":"10.1111/jcpe.70039","DOIUrl":"https://doi.org/10.1111/jcpe.70039","url":null,"abstract":"AIMTo compare long-term clinical and radiographic outcomes of a single short implant (6 mm) supporting a cantilevered restoration versus two adjacent short implants with non-splinted single crowns over a 7.5-year follow-up and determine which approach is more cost effective.MATERIALS AND METHODSA total of 36 patients with at least a two-tooth gap in the posterior region were randomised to receive either one short implant with a cantilever prosthesis (ONE-C) or two short implants with individual crowns (TWO). Fixed restorations were placed 3-6 months post implantation, and patients were evaluated at baseline and at 6 months and 1, 3, 5 and 7.5 years. Kaplan-Meier curves, mixed-effects models and cost-effectiveness models were used to compare the groups.RESULTSTwenty-five patients (15 in ONE-C, 10 in TWO) completed the 7.5-year follow-up. Implant survival was 83.3% in group ONE-C and 86.6% in group TWO, with no significant differences between the groups (p = 0.772). No statistically significant differences were found between groups for marginal bone levels (mean difference -0.16 [95% CI: -0.7 to 0.3] p = 0.57), probing depth (mean difference -0.13 [95% CI: -0.5 to 0.3] p = 0.58), bleeding on probing (mean difference 0.0 [95% CI: -0.0; 0.2] p = 0.31) or plaque levels (mean difference -0.0 [95% CI: -0.1 to 0.1] p = 0.93). Technical complications were more frequent in the ONE-C group (64%) than in the TWO group (36%).CONCLUSIONBoth treatment approaches showed comparable clinical and radiographic outcomes. Short implants supporting cantilever restorations were generally more cost effective than two short implants but exhibited higher early complication and failure rates, likely related to mechanical overload.TRIAL REGISTRATIONClinicalTrials.gov Identifier: NCT01649531.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"22 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accuracy of Robotic Computer-Assisted Implant Surgery Combined With Transcrestal Sinus Floor Elevation for Single-Tooth Implants: A Retrospective Case Series. 机器人计算机辅助种植手术结合经瓣窦底抬高治疗单牙种植体的准确性：回顾性病例系列。

IF 6.7 1区医学

Journal of Clinical Periodontology Pub Date : 2025-09-18 DOI: 10.1111/jcpe.70038

Jieyong Jia,Liangzhi Du,Longlong He,Zhe Li,Yuncong Li,Chengpeng Lv

{"title":"Accuracy of Robotic Computer-Assisted Implant Surgery Combined With Transcrestal Sinus Floor Elevation for Single-Tooth Implants: A Retrospective Case Series.","authors":"Jieyong Jia,Liangzhi Du,Longlong He,Zhe Li,Yuncong Li,Chengpeng Lv","doi":"10.1111/jcpe.70038","DOIUrl":"https://doi.org/10.1111/jcpe.70038","url":null,"abstract":"AIMTo evaluate the accuracy and safety of robotic computer-assisted implant surgery (r-CAIS) for transcrestal sinus floor elevation (TSFE) in single-tooth implant placement.MATERIALS AND METHODSIn this retrospective case series, we assessed the positional accuracy of r-CAIS combined with TSFE in the posterior maxilla. Preoperative and postoperative cone-beam computed tomography (CBCT) scans were used to determine implant positioning accuracy. Subgroup analyses evaluated the effects of various factors on accuracy. Additionally, complications were recorded and evaluated.RESULTSA total of 40 patients and 40 implants were included. Only one case (Case XIX) exhibited a Schneiderian membrane perforation, resulting in a perforation rate of 2.5% (1/40). The mean global coronal and apical deviations were 0.50 ± 0.22 mm and 0.54 ± 0.21 mm, respectively, with an angular deviation of 1.25° ± 0.61°. A linear mixed model (LMM) analysis revealed no statistically significant differences between subgroups (implant position, side of arch, bone quality, implant type, implant size and registration method) and implant deviations (p > 0.05).CONCLUSIONSr-CAIS showed excellent accuracy and safety for TSFE in single-tooth implant placement. This study suggests r-CAIS can achieve favourable clinical outcomes, although further clinical evidence is needed to confirm its broader efficacy.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"38 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145083475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of the Probiotic Limosilactobacillus reuteri as an Adjunct to Subgingival Instrumentation in the Treatment of Periodontitis Patients With Diabetes: A Randomised Clinical Trial. 使用益生菌罗伊氏乳杆菌作为牙龈下器械治疗糖尿病牙周炎患者的辅助：一项随机临床试验。

IF 6.7 1区医学

Journal of Clinical Periodontology Pub Date : 2025-09-17 DOI: 10.1111/jcpe.70035

Rocío Bujaldón,Eduardo Montero,Juan Daniel Gamonal,Alejandro Abuelo,María José Marín,Margarita Iniesta,Mariano Sanz,David Herrera

{"title":"Use of the Probiotic Limosilactobacillus reuteri as an Adjunct to Subgingival Instrumentation in the Treatment of Periodontitis Patients With Diabetes: A Randomised Clinical Trial.","authors":"Rocío Bujaldón,Eduardo Montero,Juan Daniel Gamonal,Alejandro Abuelo,María José Marín,Margarita Iniesta,Mariano Sanz,David Herrera","doi":"10.1111/jcpe.70035","DOIUrl":"https://doi.org/10.1111/jcpe.70035","url":null,"abstract":"AIMTo evaluate the clinical and microbiological effects of a Limosilactobacillus reuteri-based probiotic as an adjunct to subgingival instrumentation in untreated periodontitis patients with diabetes.METHODSA 6-month, randomised, triple-blinded clinical trial was conducted involving 40 patients, receiving steps 1 and 2 of periodontal therapy, including subgingival instrumentation, and randomised to receive tablets containing L. reuteri or placebo, for 3 months. Clinical and microbiological outcomes as well as glycosylated haemoglobin (HbA1c) concentrations were evaluated at baseline and at 3 and 6 months after therapy.RESULTSAt 6 months, both groups showed statistically significant reductions in the primary outcome (mean probing depth), with reductions of 0.9 mm in the probiotic group and 0.8 mm in the placebo group, with no significant differences between them. Both groups exhibited reductions in HbA1c levels after 6 months, more in the probiotic group (-0.6% vs. -0.1%), with statistically significant inter-group differences (-0.5%; 95% confidence interval [-1.0; 0.0]; p < 0.001). Microbiological outcomes were similar.CONCLUSIONSThe adjunctive use of a L. reuteri-based probiotic did not provide additional clinical or microbiological benefits, compared to placebo, following subgingival instrumentation in patients with periodontitis and diabetes. However, statistically significant differences in HbA1c levels were observed, with larger reductions in the probiotic group, suggesting a potential systemic benefit.TRIAL REGISTRATIONThe protocol was approved by the Clinical Research Ethics Committee (CEIC) of Hospital Clínico de San Carlos (internal code 19/101-R_X) and registered a priori in ClinicalTrials.gov (identifier NCT04069611).","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"50 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145071650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0