Journal of Clinical Periodontology最新文献

{"title":"A Multi-Centre Randomised Controlled Trial Comparing dPTFE Membrane to Collagen Membrane in Lateral Bone Augmentation at Single Sites in the Anterior Maxilla: 1-Year Results.","authors":"Matthijs Hindryckx,Thomas De Bruyckere,Stefanie De Buyser,Lorenz Seyssens,Retis Shtino,Faris Younes,Jan Cosyn","doi":"10.1111/jcpe.14174","DOIUrl":"https://doi.org/10.1111/jcpe.14174","url":null,"abstract":"AIMTo compare a dense polytetrafluoroethylene (dPTFE) membrane with a collagen membrane in guided bone regeneration for lateral bone augmentation at single sites in the anterior maxilla in terms of alveolar width, height, complications, need for additional therapy and implant outcomes.MATERIALS AND METHODSPatients with a class 4 defect at a single site in the anterior maxilla (15-25) were recruited at five centres. Following flap elevation and conditioning of the recipient site, they were randomly allocated to the dPTFE membrane group or the collagen membrane group. Nine months following bone augmentation, re-entry was performed and implants were placed. Alveolar dimensions were assessed on superimposed cone-beam computed tomography images taken prior to surgery, immediately post operation and at 9 months. Implant outcomes were registered 1 year after bone augmentation.RESULTSThirty-six patients were randomised (dPTFE membrane group: 8 females, 10 males, mean age 39; collagen membrane group: 14 females, 4 males, mean age 51) and all complied until the 1-year follow-up. At 9 months, the estimated marginal mean alveolar width was not significantly different between the groups (estimated marginal mean difference at 3 mm below the crest: 0.65 mm; 95% CI: -0.82 to 2.12; p = 0.381). Infection occurred in 6/18 patients treated with a dPTFE membrane and in 0/18 patients treated with a collagen membrane (p = 0.019). Infection occurred in every centre and had a negative impact on the alveolar width at 9 months, despite taking anti-infective measures in every patient and additional bone augmentation in two patients. Implants could be installed in a prosthetically driven position, integrated uneventfully and yielded minimal marginal bone loss.CONCLUSIONdPTFE membrane and collagen membrane are both effective in lateral bone augmentation. However, dPTFE membrane is more prone to infection than collagen membrane, thereby increasing the need for additional therapy.TRIAL REGISTRATIONClinicalTrials.gov identifier: NCT05426616.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"67 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Synergetic Effect of Periodontal Therapy and TNF‐α Inhibitor for the Treatment of Comorbid Periodontitis and Psoriasis","authors":"Crystal Marruganti, Carlo Gaeta, Chiara Falciani, Elisa Cinotti, Pietro Rubegni, Mario Alovisi, Nicola Scotti, Andrea Baldi, Cristiana Bellan, Chiara Defraia, Elena Bertaggia, Fabio Fiorino, Silvia Valensin, Erika Bellini, Antonella De Rosa, Filippo Graziani, Francesco D'Aiuto, Simone Grandini","doi":"10.1111/jcpe.14102","DOIUrl":"https://doi.org/10.1111/jcpe.14102","url":null,"abstract":"AimTo assess the adjunctive effect of periodontal therapy on psoriasis‐related outcomes in a combined experimental model of ligature‐induced periodontitis and Imiquimod (IMQ)‐induced psoriasis. Also, this experiment aimed to study the impact of TNF‐α inhibitors on the periodontium.MethodsFifty‐six C57/BL6J mice were randomly allocated to seven experimental groups: (a) control group (P–Pso–) with no treatment; (b) periodontitis (P+Pso–) with periodontal therapy; (c) periodontitis (P+Pso–) with TNF‐α inhibitor; (d) psoriasis (P–Pso+) with TNF‐α inhibitor; (e) periodontitis and psoriasis (P+Pso+) with periodontal therapy; (f) P+Pso+ with TNF‐α inhibitor; and (g) P+Pso+ with both periodontal therapy and TNF‐α inhibitor. Samples (maxilla, dorsal skin and blood) were harvested immediately after death. Measures of periodontitis distance between the cemento‐enamel junction and alveolar bone crest (CEJ–ABC) and number of osteoclasts and psoriasis (epidermal thickness and infiltrate cells (per 0.03mm<jats:sup>2</jats:sup>)) severity, as well as systemic inflammation (IL‐6, IL‐17A and TNF‐α) were collected.ResultsIn the P+Pso+ group, a significant adjunctive effect of periodontal therapy to TNF‐α inhibitors was found in the reduction of epidermal thickening and inflammatory infiltrate of the dorsal skin (<jats:italic>p</jats:italic> &lt; 0.05). Similarly, treatment with TNF‐α inhibitor resulted in a significant adjunctive effect to periodontal therapy in the reduction of alveolar bone loss (<jats:italic>p</jats:italic> &lt; 0.05). These changes were accompanied by a significant decrease in the circulating levels of IL‐6 and IL‐17A when both periodontal therapy and TNF‐α inhibitor were administered.ConclusionsThe combination of periodontal therapy and TNF‐α inhibitor showed a positive synergetic effect in the treatment of comorbid experimental ligature‐induced periodontitis and IMQ‐induced psoriasis via the reduction of systemic inflammation.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"33 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three‐Year Outcomes of Dental Implants With a Hybrid Surface Macro‐Design Placed in Patients With History of Periodontitis: A Randomised Clinical Trial","authors":"Benjamín Serrano, Ignacio Sanz‐Sánchez, Eduardo Montero, Mariano Sanz","doi":"10.1111/jcpe.14153","DOIUrl":"https://doi.org/10.1111/jcpe.14153","url":null,"abstract":"AimThis randomised controlled trial (RCT) with a 3‐year follow‐up was aimed at assessing the clinical and radiographic outcomes of implants with either a hybrid or moderately rough macro‐surface design placed in patients with a history of periodontitis.Material and MethodsForty periodontitis subjects with a stable periodontal condition were included and randomly assigned to receive either a hybrid implant with a machined‐collar surface (HS) or a conventional implant with a moderately rough‐collar surface up to the shoulder (RS). Radiographic, clinical, microbiological and patient‐related outcome measurements (PROMs) were assessed at baseline (implant loading) and 3, 6, 12, 24 and 36 months post‐loading.ResultsThirty‐six patients (17 and 19, in the test and control groups, respectively) completed the three‐year follow‐up. At this visit, mean marginal bone level (MBL) changes were −0.08 (SD 0.2) and 0.02 (SD 0.28) mm for the test and control groups, respectively, with only three patients exhibiting MBLs exceeding 1 mm and only one implant with a peri‐implantitis diagnosis. Patients in both groups showed a high degree of satisfaction, and implants in both groups harboured a similar proportion and counts of measured periodontal pathogens. No significant differences were observed between the two groups regarding any of the radiographic, clinical or microbiological variables.ConclusionsAt the three‐year follow‐up, both implant groups demonstrated high peri‐implant bone stability, as well as a low incidence of peri‐implant diseases.Trial Registration: <jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" xlink:href=\"http://clinicaltrials.gov\">ClinicalTrials.gov</jats:ext-link> (identifier NCT05010382). <jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" xlink:href=\"https://clinicaltrials.gov/ct2/show/NCT05010382?cond=peri-implantitis&amp;cntry=ES&amp;city=Madrid&amp;draw=2&amp;rank=5\">https://clinicaltrials.gov/ct2/show/NCT05010382?cond=peri‐implantitis&amp;cntry=ES&amp;city=Madrid&amp;draw=2&amp;rank=5</jats:ext-link>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"3 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Host Markers of Periodontal Diseases: Meta‐Analysis of Diagnostic Accuracy Studies","authors":"Mia Rakic, Elena Calciolari, Melissa M. Grant, Sandro Radovanovic, Nagihan Bostanci, Philip M. Preshaw","doi":"10.1111/jcpe.14167","DOIUrl":"https://doi.org/10.1111/jcpe.14167","url":null,"abstract":"ObjectiveTo identify host markers with optimal diagnostic performance for clinical implementation in the diagnosis of periodontal diseases and prediction of future disease progression and/or disease resolution.Material and MethodsCross‐sectional and prospective studies with ≥ 20 participants per group, reporting diagnostic accuracy (e.g., area under the curve [AUC]) of host markers for periodontal diagnosis (focused question 1 [FQ1]), periodontitis progression/relapse (FQ2) or resolution (FQ3) were searched in three electronic databases. Meta‐analyses estimating diagnostic accuracy (DA) for individual host markers and for grouped salivary and gingival crevicular fluid (GCF) markers independently were performed whenever two or more studies were identified.ResultsSixty‐one eligible studies were identified, of which 13 were included in meta‐analyses for FQ1 (discrimination between health and periodontitis). Matrix metalloproteinase‐8 (MMP‐8) was the most reported biomarker in both saliva and GCF, with comparable AUC (0.70–0.90), sensitivity (0.49–0.84) and specificity (0.62–0.79) in both sample types. Cytokines had good ability for discrimination of periodontitis/gingivitis versus health, although they were substantially less accurate for periodontitis versus gingivitis. Combinations of cytokines and MMPs tended to increase overall diagnostic accuracy but without significant improvement in the case of periodontitis/gingivitis discrimination. Bone markers were the best performing group of salivary markers (AUC = 0.91) when compared to cytokines (AUC = 0.86) and MMPs (AUC = 0.77). GCF microRNAs (MiRs) were a singly meta‐analysed group of biomarkers demonstrating AUC = 0.79.ConclusionReported studies on host periodontal markers exhibit serious limitations regarding clinical and validation standards, being the main cause for lack of progress in clinical implementation of biomarkers in periodontal classification. Disease‐specific markers such as bone markers showed better diagnostic performance (from limited number of studies) for the diagnosis of periodontitis when compared to cytokines and MMPs.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"7 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143849608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Method for Volumetric Analysis of Soft‐Tissue Changes Using Three‐Dimensional Imaging in Patients With Periodontitis","authors":"Aleksandar Pupovac, Davor Kuiš, Ivana Mišković, Stjepan Špalj, Alexei Zhurov, Jelena Prpić","doi":"10.1111/jcpe.14118","DOIUrl":"https://doi.org/10.1111/jcpe.14118","url":null,"abstract":"AimsTo quantify changes in soft‐tissue volume induced by non‐surgical periodontal therapy (NSPT) in patients with periodontitis and correlate them with clinical parameters and smoking. A new digital approach is investigated because standard periodontal clinical assessment methods are unable to accurately capture volumetric changes.Materials and MethodsThirty‐nine subjects with periodontitis aged 27–70 years (median 48; 51% females; 49% smokers) were included. All subjects underwent clinical examination and intraoral scanning at baseline and 8 weeks after NSPT. Digital models were superimposed, and changes in volume were analysed and correlated with clinical parameters.ResultsNSPT reduced soft‐tissue volume in both smokers and non‐smokers (<jats:italic>p</jats:italic> &lt; 0.001). Non‐smokers had a higher median change in volume than smokers (267.4 vs. 210.5 mm<jats:sup>3</jats:sup>), without statistically significant differences. Periodontal clinical parameters linearly correlated with soft‐tissue volume changes. In multiple linear regression, a higher initial proportion of pockets ≥ 5 mm was the only predictor of volume change when the effects of change in plaque score, smoking status, age and sex were controlled for (<jats:italic>p</jats:italic> = 0.015).ConclusionNSPT resulted in comparable reductions in soft‐tissue volume for both smokers and non‐smokers, which was confirmed by a new digital approach.Trial Registration: <jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" xlink:href=\"http://clinicaltrials.gov\">ClinicalTrials.gov</jats:ext-link>: NCT05719519, 25.01.2023","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"19 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143836694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Buccal Bone Resorption in Areas With or Without Keratinized Tissue and Different Mucosal Thickness at Implants in Healed Sites: An Experimental Animal Study","authors":"Antonio Liñares, Hong Jin Tan, Fernando Muñoz, Dragana Rakasevic, Yago Leira, Juan Blanco","doi":"10.1111/jcpe.14140","DOIUrl":"https://doi.org/10.1111/jcpe.14140","url":null,"abstract":"AimTo evaluate early buccal bone resorption (BBR) in areas with or without buccal keratinized tissue (KT), and different mucosal thickness (MT) following implant placement at healed sites.Materials and MethodsIn 9 beagle dogs, three months following the hemimaxilla third and fourth premolars extraction, full‐thickness flaps were elevated and two tissue‐level implants were inserted. Before suturing, each dog was randomly assigned into 3 groups (control, non‐keratinized tissue, NKT and non‐keratinized tissue plus connective tissue graft, NKT‐CTG). In both experimental groups (NKT and NKT‐CTG), buccal KT was excised. In the NKT‐CTG group, a CTG was sutured to the buccal alveolar mucosa flap (BF) and coronally repositioned around the implant neck, while in the NKT group, only the BF was repositioned. BF with a 2 mm KT band was repositioned around the implants in the control group. Buccal bone thickness (BBT), MT and KT width were measured clinically at baseline. Three months later, BBR and MT were analysed histologically.ResultsMucosal thickness at surgery was similar in NKT and control groups (1.33 ± 0.26 mm and 1.67 ± 0.52 mm, respectively). In the NKT‐CTG group, MT was 2.50 ± 0.45. The mean BBT measured at the mid‐buccal region was about 1 mm in the 3 groups. Three months later, early BBR was observed in all groups, with mean values of 0.91 mm ± 0.62 (control), 1.11 mm ± 0.69 (NKT) and 1.10 mm ± 0.58 (NKT‐CTG). The mean values of MT at a 1.5 mm distance from the marginal mucosa were 1.20 mm ± 0.69 (control), 2.18 mm ± 0.53 (NKT) and 3.45 mm ± 1.33 (NKT‐CTG).ConclusionsWithin the limitations of the present investigation, the presence or absence of KT did not affect early BBR. CTG placed in the zones without KT did not prevent early BBR.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"1 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143836744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient‐Centred Preferences for Autonomy and Information‐Seeking Among Periodontal Patients in Dental Decision Making","authors":"Ji‐Young Jung, Kyung‐A Ko, Franz J. Strauss, Jae‐Hong Lee, Jun‐Hewk Kim, Jung‐Seok Lee","doi":"10.1111/jcpe.14166","DOIUrl":"https://doi.org/10.1111/jcpe.14166","url":null,"abstract":"Background and AimManaging periodontal disease often involves complex decisions involving multiple treatment options, and patient autonomy significantly influences this decision‐making process. This study aimed to characterise the autonomy and information‐seeking preferences among patients diagnosed with stage III/IV periodontitis, and to identify the factors influencing these preferences.Materials and MethodsThe survey included 96 patients diagnosed with periodontal disease, all of whom underwent periodontal treatment or tooth extraction between May 2021 and February 2022. Participants completed a self‐administered questionnaire incorporating the Autonomy Preference Index (API) to assess their decision‐making and information‐seeking preferences, along with demographic information, using a 5‐point Likert scale.ResultsDecision‐making preferences were centrally distributed, with a score of 2.87 ± 0.47 (mean ± SD), indicating that most periodontal patients favoured a collaborative decision‐making model. In contrast, information‐seeking preferences were skewed, with a strong concentration towards the higher end of information preferences; the score was 4.55 ± 0.08. Lower age (<jats:italic>p</jats:italic> = 0.008) was associated with a preference for greater autonomy, while the financial burden (<jats:italic>p</jats:italic> = 0.034) was linked to reduced information‐seeking preferences. Patients' autonomy remained relatively consistent across different periodontal clinical scenarios.ConclusionThese findings suggest that periodontitis patients prefer to be well informed and share decision‐making responsibilities with healthcare professionals after their diagnosis. Factors such as age and financial burden affect their autonomy, involvement and desire for information.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"16 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143841304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macrophage Depletion Reduces Bone Loss and Alters Inflammatory Responses: A Mouse Peri‐Implantitis Model","authors":"Ofir Ginesin, Benjamin R. Coyac, Ofri Doppelt‐Flikshtain, Yaniv Mayer, Eran Gabay, Tal Berg, Yotam Bar‐On, Hadar Zigdon‐Giladi","doi":"10.1111/jcpe.14120","DOIUrl":"https://doi.org/10.1111/jcpe.14120","url":null,"abstract":"AimTo evaluate the impact of macrophage depletion on bone loss and inflammatory responses in a mouse model of peri‐implantitis, assessing macrophage depletion potential as a therapeutic strategy.Materials and MethodsUsing 6‐week‐old male C57BL/6 mice, peri‐implantitis was induced by placing a silk ligature around osteointegrated dental implants. Mice were divided into three groups: Healthy control (Healthy group); peri‐implantitis with liposomal phosphate‐buffered saline (PBS group); and peri‐implantitis with liposomal clodronate for macrophage depletion (CLOD group). Two weeks after ligature placement, micro‐CT, histological and real‐time PCR analyses were performed to assess bone density, leukocyte infiltration and cytokine levels.ResultsThe CLOD group showed a significantly higher bone‐to‐implant contact (74%) and bone volume relative to total volume (79%) compared to the PBS group (53% and 54%, respectively) and Healthy group (64% and 66%, respectively). Histological analysis revealed significantly reduced leukocyte and macrophage counts in the CLOD group. Additionally, TNF‐α and IL‐10 levels were significantly decreased in the CLOD group compared with the PBS group.ConclusionMacrophage depletion effectively reduces bone loss and inflammation in peri‐implantitis. This study highlights targeting macrophages as a promising approach for managing peri‐implantitis, although further research is needed to optimize therapeutic strategies.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"115 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143836692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to ‘Interrupted Time Series Analysis of Chronic Periodontitis‐Related Procedures Before and After the Scaling Reimbursement Policy in Korea’","authors":"","doi":"10.1111/jcpe.14136","DOIUrl":"https://doi.org/10.1111/jcpe.14136","url":null,"abstract":"","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"26 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143836693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Injectable Bone Fillers for Alveolar Ridge Preservation: A Histomorphometrical Analysis.","authors":"Frank Schwarz,Ausra Ramanauskaite,Karina Obreja,Jonas Lorenz,Robert Sader,Puria Parvini","doi":"10.1111/jcpe.14162","DOIUrl":"https://doi.org/10.1111/jcpe.14162","url":null,"abstract":"AIMTo assess the efficacy of injectable bone fillers for alveolar ridge preservation (ARP).MATERIALS AND METHODSThe mandibular premolars (P2, P3, P4) were bilaterally assigned to ARP in a total of n = 9 beagle dogs. Each P was decapitated and hemisected under preservation of the mesial (i.e., devitalization and filling with calcium hydroxide) and removal of the distal root. The resulting 6 extraction sockets were randomly allocated to a total of four injectable test materials (i.e., bovine bone particles + porcine collagen, lyophilized materials reconstituted with either blood or saline [T1, T2, T4]; or ready-to-use wet material [T3]) and one control material (collagenated bovine bone mineral) (C) as well as one negative control group (N). Primary wound closure was ensured in all test and C groups. At 12 weeks, dissected blocks were prepared for histomorphometrical analyses. Buccal bone height (BBH) was defined as a primary outcome. Lingual bone height (LBH), buccal and lingual bone wall width (BBW and LBW 1, 3 and 5 mm infracrestally), surface area of bone and particles, fibrous tissues, and bone marrows were defined as secondary outcomes. Between-group comparisons were assessed using ANOVA and Mann-Whitney tests.RESULTSAfter 12 weeks, all groups were associated with similar BBH values (BBH: 14.1, 14.0, 13.7, 13.8, 14.3 and 114.2 mm in the T1, T2, T3, T4, C and N groups, respectively; p > 0.05 for all between-group comparisons). The BBW and LBW measurements were comparable among the groups. ARP sites showed a trend towards higher area measurements of bone and particle surfaces compared with the N group (11.5, 11.6, 13.1, 12.5, 9.1 mm2 in T1, T2, T3, T4, C and N groups, respectively). C, T1, T2, T3 and T4 particles were associated with a similar marked grade of osteoconduction and osteointegration within the former extraction socket area.CONCLUSIONSWithin its limitations, the present study has pointed to the similar efficacy of injectable bone fillers for ARP compared with the particulated bone substitute and negative control.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"39 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143822687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}