Evaluation of the Clinical Efficacy of Copine 7‐Derived Peptides for Naturally Occurring Periodontitis in Dogs

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology Pub Date : 2025-07-07 DOI:10.1111/jcpe.14200

Se Eun Kim, Hyeonu Sung, Sehan Shin, Jinhee Bae, Giyeon Kim, Dong‐Seol Lee, Han Woong Kim, Jin‐Seok Seo, Song Yi Roh, Su‐Jin Park, Chul Son, Seong Min Roh, Jeongmin Park, Joo‐Cheol Park

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Abstract

AimTo assess the efficacy of copine7‐derived peptide (CPNE7‐DP) applied in conjunction with non‐surgical dental treatments in improving naturally occurring periodontitis in dogs.Materials and MethodsThis study included 24 client‐owned dogs with mild to moderate periodontitis, randomly assigned to three groups: CPNE7‐DP; a placebo control group receiving carrier material; and a negative control group left untreated. Experimental agents were applied after professional dental cleaning. Clinical assessments were conducted at Weeks 0, 4 and 8, which involved measurements of gingival index (GI), periodontal pocket depth (PPD), clinical attachment loss (CAL) and bleeding on probing (BoP). Alveolar bone loss (ABL) was evaluated using intraoral radiographs.ResultsApplication of CPNE7‐DP resulted in a significant improvement in GI, PPD, CAL and BoP compared with both placebo and negative control groups. ABL was significantly reduced in the CPNE7‐DP group. These clinical outcomes indicated the potential regenerative effects of CPNE7‐DP on periodontal tissues.ConclusionsTopical application of CPNE7‐DP in conjunction with non‐surgical dental treatments was effective in reducing gingival inflammation, PPD, CAL and ABL in dogs with naturally occurring periodontitis. These findings suggest the potential of CPNE7‐DP as an effective adjunctive therapeutic agent for periodontal treatment.Trial Registration: Approved by the Institutional Animal Care and Use Committee of Seoul National University (SNU‐220520‐5‐1)

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评价Copine - 7衍生肽治疗犬自然牙周炎的临床疗效

目的评价copine7衍生肽（CPNE7 - DP）联合非手术牙科治疗对犬自然牙周炎的疗效。材料和方法本研究纳入24只患有轻度至中度牙周炎的犬，随机分为三组：CPNE7‐DP；安慰剂对照组接受载体材料；阴性对照组不进行治疗。专业洗牙后使用实验药剂。在第0、4和8周进行临床评估，包括测量牙龈指数（GI）、牙周袋深度（PPD）、临床附着丧失（CAL）和探诊出血（BoP）。用口内x线片评估牙槽骨丢失（ABL）。结果与安慰剂组和阴性对照组相比，应用CPNE7‐DP可显著改善GI、PPD、CAL和BoP。CPNE7 - DP组ABL显著降低。这些临床结果表明CPNE7‐DP对牙周组织有潜在的再生作用。结论临床应用CPNE7 - DP结合非手术治疗可有效减少自然牙周炎犬的牙龈炎症、PPD、CAL和ABL。这些发现提示CPNE7‐DP作为牙周治疗的有效辅助治疗剂的潜力。试验注册：由首尔国立大学机构动物护理和使用委员会批准（SNU‐220520‐5‐1）

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来源期刊

Journal of Clinical Periodontology 医学-牙科与口腔外科

CiteScore

13.30

自引率

10.40%

发文量

175

审稿时长

3-8 weeks

期刊介绍： Journal of Clinical Periodontology was founded by the British, Dutch, French, German, Scandinavian, and Swiss Societies of Periodontology. The aim of the Journal of Clinical Periodontology is to provide the platform for exchange of scientific and clinical progress in the field of Periodontology and allied disciplines, and to do so at the highest possible level. The Journal also aims to facilitate the application of new scientific knowledge to the daily practice of the concerned disciplines and addresses both practicing clinicians and academics. The Journal is the official publication of the European Federation of Periodontology but wishes to retain its international scope. The Journal publishes original contributions of high scientific merit in the fields of periodontology and implant dentistry. Its scope encompasses the physiology and pathology of the periodontium, the tissue integration of dental implants, the biology and the modulation of periodontal and alveolar bone healing and regeneration, diagnosis, epidemiology, prevention and therapy of periodontal disease, the clinical aspects of tooth replacement with dental implants, and the comprehensive rehabilitation of the periodontal patient. Review articles by experts on new developments in basic and applied periodontal science and associated dental disciplines, advances in periodontal or implant techniques and procedures, and case reports which illustrate important new information are also welcome.