Journal of Clinical Periodontology最新文献

{"title":"The Effect of Tobacco Smoking on Tooth Loss: A Systematic Review and Meta-Analysis","authors":"Ziqi Chen,&nbsp;Gagandeep Kaur,&nbsp;Nadia Kaunein,&nbsp;Claireta Handoko,&nbsp;Marco A. Peres,&nbsp;Melissa Russell,&nbsp;Ankur Singh","doi":"10.1111/jcpe.70110","DOIUrl":"10.1111/jcpe.70110","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This systematic review aims to examine the causal effect of tobacco smoking on tooth loss. Further, the impact of different frequencies, intensities and lifetime exposures to tobacco smoking on tooth loss and whether the relationship differs by socioeconomic status (SES) are reviewed in the sub-group analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>An electronic search was conducted in Embase (Ovid), Ovid MEDLINE and Web of Science for studies published up to May 2025. No limits on publication dates were applied. This review included case–control and cohort studies that reported the effect of tobacco smoking on tooth loss. Risk of Bias of included studies was assessed by ROBINS-E assessment tool.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 30 studies were included in this systematic review. The meta-analysis from five studies indicated that current smokers have 1.41 times higher risk of tooth loss (RR 1.41, 95% CI: 1.24–1.60) than nonsmokers (sample size range: 273–34,975, <i>n</i> = 5). Past smoking also increases the risk of having tooth loss (RR 1.21, 95% CI: 1.07–1.37) (sample size range: 547–34,975, <i>n</i> = 2). None of the studies examined the effect of smoking on tooth loss by different SES.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This systematic review highlights the importance and urgency of quitting smoking for better oral health.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 5","pages":"784-805"},"PeriodicalIF":6.8,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70110","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147465373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral-Rinse-Sourced Microbiota in Oral Health and Diseases in a Representative US Adult Population: Implications for Diagnostics","authors":"Yu Xie,&nbsp;Alejandro Artacho,&nbsp;Xiaoyu Yu,&nbsp;Mengning Bi,&nbsp;Hairui Li,&nbsp;Yuan Li,&nbsp;Andrea Roccuzzo,&nbsp;Alex Mira,&nbsp;Bob T. Rosier,&nbsp;Maurizio S. Tonetti","doi":"10.1111/jcpe.70101","DOIUrl":"10.1111/jcpe.70101","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To investigate the associations between oral-rinse microbiota and distinct oral conditions, and further evaluate its potential ability to distinguish periodontitis severity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Oral-rinse-sourced microbiota with 16S ribosomal RNA sequencing from 3770 adults in US National Health and Nutrition Examination Survey 2009–2012 were analysed across oral health, caries, periodontitis, co-existing caries and periodontitis and edentulism. Diagnostic potential of the oral-rinse microbiota for periodontitis severity was evaluated using multi-class random forest (RF) model with internal validation and external validation in an independent cohort (<i>n</i> = 392).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Oral condition accounted for substantial variance in oral-rinse microbiota, revealing disease or tooth loss–associated shifts. Increasing acidogenic/aciduric taxa (<i>Veillonella</i>, <i>Lactobacillus</i>, <i>Atopobium</i>) or periodontitis-associated taxa (<i>Filifactor</i>, <i>Treponema</i>, <i>Tannerella</i>) were identified in caries-only or periodontitis-only groups, respectively, while the co-existing disease group showed overlapping shifts. Taxa shifted dose-dependently with increasing periodontitis severity. The RF model achieved moderate performance in identifying severe periodontitis, with the area under the receiver operating characteristic curve (AUROC) of 0.81 (0.75–0.87) internally and 0.83 (0.77–0.88) externally. Key contributing taxa aligned with established periodontitis-associated genera, supporting model interpretability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Based on our results, oral-rinse microbiota captures disease-specific signatures across oral conditions, supporting its potential as a non-invasive tool to monitor oral microbial ecology and assess periodontitis severity at the population level.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 5","pages":"760-773"},"PeriodicalIF":6.8,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70101","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145968458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Biologics for Surgical Treatment of Periodontal Suprabony Defects: A Systematic Review and Meta-Analysis of Controlled Clinical Trials","authors":"Sahar Baniameri,&nbsp;Parham Hazrati,&nbsp;Hamoun Sabri,&nbsp;Abdusalam E. Alrmali,&nbsp;Lucrezia Parma-Benfenati,&nbsp;Saeed A. ElRefaei,&nbsp;Hom-Lay Wang,&nbsp;Muhammad H. A. Saleh","doi":"10.1111/jcpe.70078","DOIUrl":"10.1111/jcpe.70078","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Limited bone support in suprabony defects hinders predictable regeneration, but adjunctive biologics can improve results. This systematic review and meta-analysis aimed to evaluate the clinical efficacy of adjunctive biologics combined with open flap debridement (OFD) compared with OFD alone when treating suprabony defects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A systematic literature search was performed to identify controlled trials evaluating adult patients presenting horizontal periodontal defects. The primary outcome included residual probing depth (PD). Random-effects meta-analyses were performed; heterogeneity was assessed using <i>I</i>\u0000 ² statistics; risk of bias was evaluated using Cochrane RoB-2; and evidence of quality was appraised via the GRADE framework.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Nine studies comprising 303 patients were included. Adjunctive use of biologics—including enamel matrix derivative (EMD), platelet-rich fibrin (PRF) and hyaluronic acid (HA)—significantly enhanced clinical outcomes compared to OFD alone, with pooled mean differences favouring EMD and PRF for both residual PD (−0.89 and −0.42 mm) and clinical attachment level (CAL) (−1.32 and −0.69 mm). While subgroup differences were observed, notably with EMD, high heterogeneity was present for CAL and PD, and evidence of certainty ranged from low to very low.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Adjunctive biologics improve clinical outcomes in suprabony periodontal defects; however, rigorous standardised trials are needed for reaching firm conclusions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 5","pages":"735-751"},"PeriodicalIF":6.8,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70078","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145971832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Residual Pockets in Stage III and IV Periodontitis Using an Oscillating Chitosan Device With or Without a Chitosan Gel—A Randomised Parallel-Arms Clinical Trial","authors":"Ole Klein,&nbsp;Maria G. Balta,&nbsp;Johan Caspar Wohlfahrt","doi":"10.1111/jcpe.70086","DOIUrl":"10.1111/jcpe.70086","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To compare non-surgical subgingival re-instrumentation with an oscillating chitosan brush (OCB), with and without a novel chitosan hydrogel (LGX), in residual or recurrent pockets in step 3 or 4 of stage III–IV periodontitis patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Patients presenting with residual 5–8 mm probing pocket depth (PPD) and modified bleeding on probing (mBOP) scores of 2 or 3 at 3–8 teeth were randomly assigned to treatment with either an OCB alone or OCB combined with LGX gel. Treatment was repeated at 3 months. Examinations took place at baseline (BL) and at 1 (Tp1), 3 (Tp2) and 6 months (Tp3) thereafter. Primary outcomes comprised changes in PPD, mBOP and pocket closure (PC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Thirty-eight patients were included in the analysis. Both treatments resulted in significant PPD and mBOP reductions at all follow-ups. However, sites treated with adjunctive LGX resulted in significantly greater PPD reductions and higher rates of PC compared to OCB alone (Tp2: PPD reductions 1.55 vs. 1.04, <i>p</i> &lt; 0.001; PC: 67.1% vs. 46.4%, <i>p</i> &lt; 0.001; Tp3: PPD reductions 1.73 vs. 1.33, <i>p</i> = 0.001; PC: 76.8% vs. 60.8%, <i>p</i> &lt; 0.01).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Adjunctive LGX gel application enhanced the efficacy of repeated subgingival re-instrumentation with OCB, reducing the need for additional step 3 interventions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>\u0000 ClinicalTrials.gov identification number: NCT05773911, first submitted: 2022-09-15 (https://clinicaltrials.gov/study/NCT05773911)</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 5","pages":"706-718"},"PeriodicalIF":6.8,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-Tissue Bacteriome and Cellular Profiles in Periodontal Granulation Tissue From Osseous Defects and Extraction Sockets","authors":"Tianfan Cheng,&nbsp;Tianle Li,&nbsp;Tsz Yung Wong,&nbsp;Beibei Chen,&nbsp;Chongshan Liao,&nbsp;Xun Ding,&nbsp;Hui Chen,&nbsp;Wei Qiao,&nbsp;George Pelekos,&nbsp;Lijian Jin","doi":"10.1111/jcpe.70108","DOIUrl":"10.1111/jcpe.70108","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To investigate the intra-tissue bacteriome and cell profiles within periodontal granulation tissue (PGT) for exploring the biological essence and translational potentials.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>PGT samples were collected from 49 patients with severe periodontitis—including those from osseous defects (GT) during periodontal surgery, extraction sockets (ST) and extracted root surfaces (RT) during tooth extraction—while the excised pocket wall (PT) from surgical sites served as the control for diseased tissues. These samples underwent 16S rRNA sequencing, single-cell sequencing and histological assessment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>GT and PT exhibited periodontal health–associated, commensal-enriched bacteriome profiles, while RT and ST showed worse local periodontal condition, enriched periodontopathogens but depleted commensals. Notably, GT contained a higher proportion of mesenchymal stem cells (MSCs) and fibroblasts while fewer natural killer cells than in PT and ST. Pseudotime trajectory analysis revealed endothelial and epithelial differentiation fates from mesenchymal progenitors across tissues. Moreover, there were less inflammatory infiltration and immunoreactivity of CD4⁺ and NKG2D⁺ in GT than in PT and ST.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our findings suggest potential periodontal health–associated features of GT regarding clinical, bacteriome and cellular attributes. Future translational study is warranted to explore GT as an alternative source of MSCs for periodontal regeneration.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 5","pages":"806-820"},"PeriodicalIF":6.8,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70108","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147276383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Adjunctive Systemic Antibiotics on the Outcomes of Non-Surgical Periodontal Therapy: A Retrospective Cohort Study","authors":"Georgios S. Chatzopoulos,&nbsp;Larry F. Wolff","doi":"10.1111/jcpe.70117","DOIUrl":"10.1111/jcpe.70117","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate the real-world comparative effectiveness of various adjunctive systemic antibiotic regimens in combination with scaling and root planing (SRP) using a large, multi-centre retrospective cohort.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Electronic health records were used retrospectively to categorise periodontitis patients into ‘SRP Only’ or ‘SRP + Antibiotic’ groups based on prescriptions within 7 days of therapy. Primary outcomes included changes in probing depth (PD), clinical attachment level (CAL), percentage of sites with PD ≥ 4 mm and bleeding on probing (BOP). Secondary outcomes assessed tooth-level worsening in mobility or furcation status.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 3125 patients, the amoxicillin + metronidazole combination was found to be statistically superior to SRP alone for reducing PD, BOP and residual disease burden. It significantly reduced the odds of worsening tooth mobility by 63% and furcation involvement by 50%. While azithromycin and doxycycline improved CAL, the benefits of the amoxicillin + metronidazole combination were most pronounced in Stage III/IV (severe) periodontitis (−11.4% residual burden reduction, OR 4.55 for clinical success), compared to a modest effect in Stage I/II disease (−3.8%, <i>p</i> = 0.030).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Adjunctive systemic antibiotics, particularly the amoxicillin + metronidazole combination, significantly enhance clinical outcomes in non-surgical periodontitis treatment compared to SRP alone, with the greatest benefits seen in severe disease.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 5","pages":"719-734"},"PeriodicalIF":6.8,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70117","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147465372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Free Gingival Grafts With or Without Xenogeneic Collagen Matrix Increase Peri-Implant Keratinised Mucosa in Reconstructed Maxillae: A 1-Year Prospective Cohort Study","authors":"Xiancheng Zeng,&nbsp;Yanjun Ge,&nbsp;Jiayun Dong,&nbsp;Jianfeng Liufu,&nbsp;Xiaofeng Shan,&nbsp;Ruifang Lu","doi":"10.1111/jcpe.70113","DOIUrl":"10.1111/jcpe.70113","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate peri-implant keratinised mucosa augmentation using free gingival grafts (FGG) versus a combined FGG/xenogeneic collagen matrix (XCM) approach in reconstructed maxillae.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This prospective, non-randomised cohort study included patients with vascularised bone flap reconstructed maxillae. Keratinised mucosa width (KMW) was measured pre-operatively (baseline), immediately after operation and at 1 year. The primary outcome was buccal KMW gain, which was analysed using adjusted mixed-effects models with random intercepts. Exploratory histological evaluation was performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty-five patients (76 implants) were included. Baseline buccal KMW was 0.00 ± 0.00 mm (FGG) and 0.02 ± 0.15 mm (FGG/XCM). At 1 year, it increased to 4.00 ± 1.60 mm (FGG) and 2.51 ± 1.22 mm (FGG/XCM). The adjusted mean difference in buccal KMW gain was 0.84 mm (95% CI: −0.09 to 1.77 mm; <i>p</i> = 0.074); 97% and 93% of implants achieved palatal KMW ≥ 2 mm, respectively (adjusted <i>p</i> = 0.803). Vestibular depth positively predicted buccal KMW gain. Histologically, FGG sites exhibited features of orthokeratinised epithelium, whereas XCM sites resembled parakeratinised epithelium.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>KMW increased in both approaches. Although buccal KMW gain tended to be greater with the FGG approach, the non-randomised design and potential residual confounding limit definitive comparisons.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>ChiCTR2000041104</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 5","pages":"694-705"},"PeriodicalIF":6.8,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147461775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment Outcome of Surgical Protocols for Peri-Implantitis: A Retrospective Cohort Study in a Specialised University Centre","authors":"Wenjie Zhou,&nbsp;Ausra Ramanauskaite,&nbsp;Clemens Raabe,&nbsp;Emilio A. Cafferata,&nbsp;Neelam Lingwal,&nbsp;Frank Schwarz","doi":"10.1111/jcpe.70115","DOIUrl":"10.1111/jcpe.70115","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To explore the treatment outcome of surgical peri-implantitis protocols in a university-based setting.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Four-hundred and six implants in 223 patients were surgically treated by four trained surgeons using open-flap debridement (OFD, 37 implants), implantoplasty (Impl, 39 implants), reconstructive surgery (Rec, 241 implants) or a combined approach (Comb, 89 implants). Treatment success after 1 year (maximum probing depth (max PD) ≤ 5 mm, bleeding on probing (BOP) at ≤ 1 site and no suppuration) was the primary outcome. Logistic regression was used to explore associations between patient-/implant-related factors, treatment modalities and treatment success, implant loss and surgical retreatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Treatment was successful in 54.7% of implants after 1 year: OFD 62.5%, Impl 58.3%, Rec 55.4%, Comb 48.3%, with no significant group differences. Over a mean follow-up of 30.80 ± 19.62 months, 40 implants (9.9%) were lost and 38 (9.4%) required surgical retreatment. In exploratory multivariable analyses, systemic antibiotic use (pre-operative: OR = 3.54, <i>p</i> = 0.04; pre- and post-operative: OR = 4.49, <i>p =</i> 0.02) and surgeon experience (OR = 0.12, <i>p</i> = 0.003) showed associations with treatment success. Molar site (OR = 3.21, <i>p</i> = 0.03), antibiotic (pre- and post-operative: OR = 3.13, <i>p</i> = 0.02) and baseline suppuration (OR = 4.51, <i>p</i> = 0.002) were associated with implant loss. Surgical retreatment was associated with overdenture (OR = 3.59, <i>p</i> = 0.003) and max PD at baseline (OR = 1.30, <i>p</i> = 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Surgical peri-implantitis outcome was associated with systemic antibiotic, surgeon, molar site, overdenture, baseline suppuration and PD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 5","pages":"658-680"},"PeriodicalIF":6.8,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70115","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147461773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Reconstructive Peri-Implantitis Treatment for 3- and 4-Wall Bone Defects: A Single-Blind Randomised Controlled Trial With a 1-Year Follow-Up.","authors":"Jarno Hakkers,Yvonne C M de Waal,Barzi Gareb,Henny J A Meijer,Gerry M Raghoebar","doi":"10.1111/jcpe.70123","DOIUrl":"https://doi.org/10.1111/jcpe.70123","url":null,"abstract":"AIMTo evaluate the effect of a reconstructive procedure during surgical treatment of peri-implantitis in 3- or 4-wall bone defects on clinical and radiographic outcomes after 1 year follow-up.MATERIALS AND METHODSFifty-two patients with peri-implantitis were randomly assigned to surgical treatment with (n = 27) or without (n = 25) a reconstructive procedure using autologous bone, xenograft and a collagen membrane. Primary outcomes were the mean peri-implant probing depth (PPD) and radiographic marginal bone level (MBL). Bleeding on probing (BoP) was the prespecified primary outcome in the original protocol; the present report emphasises PPD and MBL outcomes relevant to reconstructive treatment. Secondary outcomes included BoP, disease resolution (composite treatment outcome), suppuration (SoP), mid-buccal recession (Midbuc REC) and keratinised mucosa (Midbuc KM). Data were analysed using multilevel mixed-effects models.RESULTSMixed-effects models showed that patients in the test group showed enhanced marginal bone levels at all follow-ups (β = -0.85 to -1.65 mm; p ≤ 0.04) and less mid-buccal recession (β = -1.06 to -1.68 mm; p ≤ 0.01) compared to the control group. No significant differences were observed for PPD, BoP, SoP, Midbuc KM or disease resolution.CONCLUSIONWhile the adjunctive reconstructive procedure did not significantly influence peri-implant PPD, BoP, SoP or disease resolution, it was associated with improved radiographic marginal bone levels and reduced mid-buccal soft-tissue recession.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"68 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147695186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet-Rich Fibrin (PRF) Promotes Maxillary Sinus Bone Regeneration: A Randomised Clinical Trial and Proteomic Analysis","authors":"Sheng Chen,&nbsp;Huixin Lv,&nbsp;Sicong Ren,&nbsp;Yihan Wang,&nbsp;Jing Zhou,&nbsp;Siyu Chen,&nbsp;Xiuyu Liu,&nbsp;Jiameng Zhang,&nbsp;Yuanxin Guo,&nbsp;Jingxia Chen,&nbsp;Jiaxin Luo,&nbsp;Yangfan Pei,&nbsp;Dixin He,&nbsp;Jingjie Zhai,&nbsp;Yanmin Zhou","doi":"10.1111/jcpe.70103","DOIUrl":"10.1111/jcpe.70103","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To compare the percentage of new bone formation as the primary outcome of bone regeneration at 6 months after maxillary sinus floor elevation (MSFE) using platelet-rich fibrin (PRF) combined with deproteinised bovine bone mineral (DBBM) versus DBBM alone, and to explore the molecular mechanisms through which PRF modulates osteogenesis in the maxillary sinus.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Forty patients undergoing MSFE were randomly allocated to two groups: DBBM alone or PRF + DBBM. Six months post MSFE, bone core samples were harvested during implant placement. Clinical outcomes included implant stability and postoperative complications. Radiographic analyses quantified graft height and volumetric changes. Bone regeneration was evaluated by micro-computed tomography (micro-CT) and histomorphometry, while osteogenic marker expression was examined using RT-qPCR and immunofluorescence. Proteomic profiling, followed by Western blot validation, was performed to identify signalling pathways associated with PRF-induced osteogenesis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The PRF + DBBM group (<i>n</i> = 20; 42 implants) showed significantly higher primary implant stability (71.85 ± 4.96 vs. 67.65 ± 5.19, <i>p</i> &lt; 0.05). Histological analysis revealed a significantly greater amount of newly formed bone with improved quality, as indicated by higher new bone formation (28.81% ± 4.41% vs. 22.44% ± 4.40%, <i>p</i> &lt; 0.001) and increased bone maturity (57.05% ± 7.76% vs. 49.17% ± 7.09%, <i>p</i> &lt; 0.01) compared to the DBBM group (<i>n</i> = 20; 45 implants). Molecular assays showed up-regulated osteogenic gene and protein expression, with activation of TGF-β, PI3K–Akt and complement and coagulation cascade pathways.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>PRF combined with DBBM resulted in improved new bone formation in the maxillary sinus compared to DBBM alone and showed superior healing outcomes, potentially mediated by key growth factors and the complement protein C1q.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 5","pages":"681-693"},"PeriodicalIF":6.8,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146215578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}