Journal of Clinical Periodontology最新文献

{"title":"Unveiling the Link Between Oral Microbiome Diversity and Biological Ageing: A Cross‐Sectional Study","authors":"Jiarui Hou, Anli Weng, Zhiwen Yang, Xuchun Huang, Wenting Chen, Xiaoyun Wang","doi":"10.1111/jcpe.14172","DOIUrl":"https://doi.org/10.1111/jcpe.14172","url":null,"abstract":"AimTo investigate the relationship between oral microbiome diversity and biological ageing acceleration in a nationally representative U.S. sample.MethodsData from 7716 participants in NHANES (2009–2012) were analysed. Oral microbiome diversity was assessed, and biological ageing acceleration was calculated using a validated algorithm. Generalised linear models, restricted cubic splines and smooth curve fitting were applied to evaluate associations.ResultsHigher α‐diversity of the oral microbiome was significantly negatively correlated with biological ageing acceleration. Stratified analyses revealed that this protective effect was particularly pronounced in men and individuals with hypertension and diabetes. β‐Diversity analysis showed significant differences in the association between microbial community composition and biological ageing acceleration, with immune functions potentially modulating these effects. Furthermore, key intervals of α‐diversity were identified, which may serve as potential targets for future research on delaying ageing.ConclusionsIn the general U.S. population, greater oral microbiome diversity was associated with lower biological ageing acceleration, especially among men and those with hypertension and diabetes. This association was also observed in Mexican and Hispanic populations.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"85 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Clinical Efficacy of Copine 7‐Derived Peptides for Naturally Occurring Periodontitis in Dogs","authors":"Se Eun Kim, Hyeonu Sung, Sehan Shin, Jinhee Bae, Giyeon Kim, Dong‐Seol Lee, Han Woong Kim, Jin‐Seok Seo, Song Yi Roh, Su‐Jin Park, Chul Son, Seong Min Roh, Jeongmin Park, Joo‐Cheol Park","doi":"10.1111/jcpe.14200","DOIUrl":"https://doi.org/10.1111/jcpe.14200","url":null,"abstract":"AimTo assess the efficacy of copine7‐derived peptide (CPNE7‐DP) applied in conjunction with non‐surgical dental treatments in improving naturally occurring periodontitis in dogs.Materials and MethodsThis study included 24 client‐owned dogs with mild to moderate periodontitis, randomly assigned to three groups: CPNE7‐DP; a placebo control group receiving carrier material; and a negative control group left untreated. Experimental agents were applied after professional dental cleaning. Clinical assessments were conducted at Weeks 0, 4 and 8, which involved measurements of gingival index (GI), periodontal pocket depth (PPD), clinical attachment loss (CAL) and bleeding on probing (BoP). Alveolar bone loss (ABL) was evaluated using intraoral radiographs.ResultsApplication of CPNE7‐DP resulted in a significant improvement in GI, PPD, CAL and BoP compared with both placebo and negative control groups. ABL was significantly reduced in the CPNE7‐DP group. These clinical outcomes indicated the potential regenerative effects of CPNE7‐DP on periodontal tissues.ConclusionsTopical application of CPNE7‐DP in conjunction with non‐surgical dental treatments was effective in reducing gingival inflammation, PPD, CAL and ABL in dogs with naturally occurring periodontitis. These findings suggest the potential of CPNE7‐DP as an effective adjunctive therapeutic agent for periodontal treatment.Trial Registration: Approved by the Institutional Animal Care and Use Committee of Seoul National University (SNU‐220520‐5‐1)","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"13 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scandinavian and North American Moist Snuff and Periodontitis: A Systematic Review and Meta-Analysis.","authors":"Mai Soon Solberg,Anne Isine Bolstad,Stein Atle Lie,Siddharth Shanbhag,Dagmar Fosså Bunæs","doi":"10.1111/jcpe.14197","DOIUrl":"https://doi.org/10.1111/jcpe.14197","url":null,"abstract":"AIMTo answer the focused PECOS question: in humans (P), what is the effect of Scandinavian or North American moist snuff (MS) (E), in comparison to non-use (C), in terms of periodontitis (O) as demonstrated in clinical studies (S)?METHODSElectronic databases (MEDLINE, EMBASE and Cochrane) and grey literature were searched for relevant studies reporting clinical and/or patient-reported periodontal outcomes. Qualitative and quantitative syntheses (random-effects meta-analysis with pooled odds ratios [ORs] or effect sizes [ESs] and 95% confidence intervals [CIs]) were performed to determine the associations between MS use and primary (periodontitis) or secondary outcomes (gingival recession, gingivitis). Risk of bias (Newcastle-Ottawa scale) and certainty of evidence (GRADE) were assessed.RESULTSTwenty-two mostly cross-sectional studies from Sweden (n = 11), the United States (n = 10) and Norway (n = 1) were included. MS use was most frequently associated with buccal recession. Qualitatively, an association between MS use and periodontitis (n = 16) was judged to be unlikely. Based on studies with high clinical heterogeneity, no significant associations were found between MS use and periodontitis (n = 2 [12,775 participants], OR = 1.49 [CI: 0.71-3.16]), recessions (n = 9 [3719 participants], ES = -0.04 [CI: -0.98 to 0.90]) or gingivitis (n = 3 [1429 participants], ES = 0.09 [CI: -0.36 to 0.55]). The certainty of evidence was judged to be very low.CONCLUSIONThe current evidence, mostly based on cross-sectional studies and very low certainty, suggests that Scandinavian or North American MS use is not associated with periodontitis.PROSPEROCRD42023417652.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"243 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144488268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging Technologies and Algorithms for Periodontal Screening and Risk of Disease Progression in Non-Dental Settings: A Scoping Review","authors":"Eduardo Montero,&nbsp;Nerea Sánchez,&nbsp;Ignacio Sanz-Sánchez,&nbsp;Mercedes López-Durán,&nbsp;Ana Carrillo de Albornoz,&nbsp;Thomas Dietrich","doi":"10.1111/jcpe.14168","DOIUrl":"10.1111/jcpe.14168","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate different tools to screen for periodontal diseases and/or evaluate the risk for disease progression in non-dental clinical settings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>The PRISMA Extension for Scoping Reviews (PRISMA-ScR) guideline was followed. A systematic search was conducted on three databases. In order to provide a comprehensive picture of periodontal diseases (Population) screening and risk assessment tools (Concept) in non-dental settings (Context), the available information was identified and presented in terms of the sources of data/domains assessed and, eventually, how the tools/algorithms were validated. The risk of bias was assessed using the QUADAS-2 tool.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 5313 articles were identified for abstract screening. Finally, 102 were included for data synthesis. The included studies were classified into domains/clusters. Only two studies focused on risk assessment for disease progression. Algorithms designed to screen for gingivitis tended to present low sensitivity values, while the screening performance improved for periodontitis, particularly for severe periodontitis. Validated self-reported questionnaires plus socio-demographic determinants (e.g., age), certain biomarkers in saliva (e.g., activated matrix metalloproteinase-8, aMMP-8) and artificial intelligence (AI) algorithms based on orthopantomographs (OPGs) present the best screening capacity for periodontitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Screening for periodontitis in non-dental settings is feasible. Validated self-reported questionnaires remain the gold standard for screening severe periodontitis in non-dental settings, although AI algorithms based on biomarkers in saliva, or derived from OPGs, have shown promising results.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 S29","pages":"246-291"},"PeriodicalIF":5.8,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of Subgingival Plaque Microbiome in Japanese Older Adults With Healthy Gingiva.","authors":"Tomoki Akatsu,Hatsumi Souno,Akihiko Fujii,Yoshihiko Minegishi,Noriyasu Ota,Yoshihisa Yamashita","doi":"10.1111/jcpe.14192","DOIUrl":"https://doi.org/10.1111/jcpe.14192","url":null,"abstract":"AIMTo elucidate the characteristics of the subgingival plaque microbiome in older adults without gingival inflammation.MATERIALS AND METHODSSubgingival plaque from 180 participants was collected and analysed using 16S rRNA sequencing. Based on the clinical parameters at the sampling sites, participants were categorised as healthy (gingival index [GI] = 0, maximum probing pocket depth [PPDmax] ≤ 2.0 and gingival recession [GR] = 0) or non-healthy (GI > 0, or PPDmax > 2.0 or GR > 0). Each group was further stratified by age into younger (< 65 years) and older (≥ 65 years) subgroups. We performed diversity and linear discriminant effect size (LEfSe) analyses to elucidate microbiome characteristics of healthy older adults.RESULTSWe observed differences in α-diversity and β-diversity between younger and older individuals only in the healthy group. Healthy older individuals showed a lower α-diversity index, indicating a healthy-like profile shift and also a significantly greater difference in β-diversity from the non-healthy group than the healthy younger subgroup. LEfSe analysis indicated that six amplicon sequence variants (ASVs), such as Rothia dentocariosa, Neisseria perflava and Actinomyces sp. HMT-448, were predominant in the healthy older subgroup.CONCLUSIONMaintaining lower α-diversity, with an abundance of R. dentocariosa and N. perflava, which are possible nitrate-reducing bacteria, may contribute to lifelong healthy gingiva by preventing microbial dysbiosis.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"7 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Recombinant Human Epidermal Growth Factor on Healing of Palatal Donor Sites: A Randomised, Controlled, Double‐Blinded, Single‐Centre Clinical Trial (EGF TRIAL)","authors":"Saravanan Sampoornam Pape Reddy, Delfin Lovelina Francis, Ruchi Harish, Kumara Raja, Sukhbir Singh Chopra","doi":"10.1111/jcpe.14187","DOIUrl":"https://doi.org/10.1111/jcpe.14187","url":null,"abstract":"AimTo assess the efficacy of topical rhEGF on healing outcomes at palatal soft‐tissue donor sites.Materials and MethodsThis randomised, controlled clinical trial included 60 patients who required harvesting of palatal soft‐tissue grafts. Out of two groups, the intervention group received rhEGF gel (60 μg/application for 5 days) and the comparator group received a placebo gel. Wound healing was assessed by wound area reduction and palatal early healing index (PEHI). Post‐operative pain was assessed using the numerical rating scale (NRS; 0–10), including donor site complications. Measurements were recorded daily for the first 5 days and at 2, 4 and 8 weeks post‐operatively.ResultsFifty‐five participants completed the trial, with dropouts in both groups (intervention [<jats:italic>n</jats:italic> = 3], control [<jats:italic>n</jats:italic> = 2]). The test group showed significantly faster healing, as evidenced by higher PEHI scores (<jats:italic>p</jats:italic> = 0.0011) and greater wound area reduction (<jats:italic>p</jats:italic> = 0.0057). Post‐operative pain was reduced significantly in the rhEGF group, and pain was nearly absent from day 2 onwards (<jats:italic>p</jats:italic> = 0.0004). No adverse effects were reported in the intervention group, whereas three participants in the control group experienced prolonged post‐operative pain.ConclusionsTopical rhEGF for 5 days significantly enhanced palatal donor site healing, reduced the wound area and alleviated post‐operative pain.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"25 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontitis and Subgingival Plaque Microbiota Associated With Brain Grey Matter Volume and Cognitive Impairment","authors":"Wenrui Wang, Yufei Tao, Wanqiu Zhu, Ziwen Gao, Yuqing Li, Wei Ye, Yun Lu, Xiao Chen, Ju Ma, Shanshan Zhou, Xiaohu Li, Yongqiang Yu, Xiaoshu Li","doi":"10.1111/jcpe.14196","DOIUrl":"https://doi.org/10.1111/jcpe.14196","url":null,"abstract":"AimTo explore if periodontitis and subgingival plaque microbiota have a relation with brain regional grey matter volume (rGMV) and their association with impaired cognition.Material and MethodsClinical periodontal data, subgingival plaque, cognitive test and brain MRI data were collected from 137 participants. rGMVs were compared among groups and subgroups with different periodontal conditions. Correlation analyses and multivariate linear regression were conducted to explore the relationship betweem rGMV, clinical periodontal indices, subgingival plaque microbiota and cognition. The random forest method was used to find the best model for cognition status prediction.ResultsThere were significant differences in rGMV of the left calcarine fissure and the surrounding cortex, bilateral lingual, left inferior parietal marginal, left superior parietal, left lenticular nucleus pallidum, left posterior orbital gyrus, left cuneus and left middle frontal gyrus of orbital part among groups with different periodontal conditions. In whole and subgroup analyses, the major trends were the same: patients with severe periodontitis had smaller rGMV. The clinical indicators of periodontitis and the composition of the subgingival microbiota were associated with rGMV and impaired cognition. Further, cognitive prediction model accuracy was improved by adding periodontitis‐related information.ConclusionsSubgingival plaque microbiota and periodontitis were associated with rGMV and cognitive decline.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"25 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glomerular Haematopoietic Prostaglandin D Synthase-Prostaglandin D2 Axis Contributes to the Periodontitis-Related Exacerbation of Diabetic Nephropathy in KK-Ay Mice","authors":"Kohei Sato,&nbsp;Takanori Shinjo,&nbsp;Tatsuro Zeze,&nbsp;Al-kafee Ahmed,&nbsp;Honoka Otsuka,&nbsp;Hisashi Yokomizo,&nbsp;Naoichi Sato,&nbsp;Mio Imagawa,&nbsp;Yuki Nishimura,&nbsp;Naoaki Ryo,&nbsp;Akiko Yamashita,&nbsp;Takao Fukuda,&nbsp;Terukazu Sanui,&nbsp;Misaki Iwashita,&nbsp;Fusanori Nishimura","doi":"10.1111/jcpe.14180","DOIUrl":"10.1111/jcpe.14180","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>Recent clinical studies have proposed a potential association between chronic kidney diseases, including diabetic nephropathy (DN) and periodontitis. Nevertheless, the causal relationship of periodontitis with DN and the underlying molecular mechanisms remain unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Ligature-induced experimental periodontitis (LIP) was induced in KK-A^y mice to investigate the molecular mechanisms underlying the LIP-mediated aggravation of glomerular pathology in DN. Outpatients with type 2 diabetes (T2D) at Kyushu University Hospital were recruited to confirm the association of renal dysfunction and periodontitis with a urinary factor identified by RNA sequencing (RNA-seq) in the mouse glomeruli.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>LIP aggravated renal dysfunction and glomerular pathologies in KK-A^y mice. RNA-seq in the glomeruli revealed haematopoietic prostaglandin D synthase (HPGDS) as the possible factor bridging periodontitis with DN progression. Glomerular PGD2 levels in KK-Ay mice were significantly elevated by LIP. Oral administration of an HPGDS inhibitor, HQL-79, successfully prevented LIP-mediated DN progression in KK-A^y mice by lowering glomerular PGD2 levels. Urinary HPGDS-to-creatinine ratio could be associated with renal dysfunction and periodontitis in outpatients with T2D.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Periodontitis may contribute to DN progression via the glomerular HPGDS–PGD2 axis. These results suggest a novel mechanism in periodontitis-related DN progression.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 8","pages":"1211-1220"},"PeriodicalIF":5.8,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14180","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TREM-1 Pathway Biomarkers for Classification of Periodontal Diseases and Monitoring of Treatment Response in Grade B and C Periodontitis.","authors":"Angelika Silbereisen,Ronaldo Lira-Junior,Beral Afacan,Ozgen-Veli Özturk,Gülnur Emingil,Nagihan Bostanci","doi":"10.1111/jcpe.14195","DOIUrl":"https://doi.org/10.1111/jcpe.14195","url":null,"abstract":"BACKGROUNDThis study investigated the diagnostic potential of salivary triggering receptor expressed on myeloid cells (TREM)-1, peptidoglycan recognition protein 1 (PGLYRP1) and interleukin (IL)-1β for periodontitis patients and their ability to predict treatment outcome.METHODSSystemically healthy, non-smokers with gingivitis (n = 31), stage III periodontitis (34 grade B: n = 34, grade C: n = 24) and healthy controls (n = 34) were recruited. Periodontitis patients (n = 42) underwent non-surgical periodontal treatment. Saliva was collected at baseline (T0) and post-treatment (T1, T3, T6). Biomarkers were measured using immunoassays. Periodontitis patients were categorised into responders (n = 19) and non-responders (n = 23) based on the number of residual pockets ≥ 5 mm with bleeding on probing at T6.RESULTSTREM-1 was higher in periodontitis than in gingivitis and health, and in periodontitis grade B than in gingivitis (p < 0.05). PGLYRP1 and IL-1β were higher in periodontitis and gingivitis compared to controls (p < 0.01). All biomarkers discriminated periodontitis from health (AUC ≥ 0.9) with high sensitivity (82.1%-92.8%) and specificity (83.3%-88.9%). TREM-1 differentiated periodontitis from gingivitis (AUC = 0.72) with high sensitivity (92.8%) but low specificity (58.1%). Baseline biomarkers did not predict treatment outcome (AUC ≤ 0.61), while T1 levels showed moderate potential (AUC ≥ 0.71).CONCLUSIONSSalivary TREM-1 pathway biomarkers offer diagnostic value for periodontitis, are modulated by therapy but show limited ability to predict treatment outcome.STUDY REGISTRATIONThe study has been registered in ClinicalTrials.gov (ID: NCT06715176, 4 December 2024).","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"87 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aesthetics and Patient-Reported Outcomes in Periodontology and Implant Dentistry: Consensus Report.","authors":"Maurizio Tonetti, Mariano Sanz, Francesco Cairo, Jose Nart, Iain Chapple, Mario Aimetti, Sofia Aroca, Gustavo Avila-Ortiz, Juan Blanco, Antonio Bujaldón, Raffaele Cavalcanti, Pierpaolo Cortellini, Jan Cosyn, Monique Danser, Massimo de Sanctis, Jan Derks, Henrik Dommisch, Elena Figuero, Rodolfo Gianserra, Filippo Graziani, Søren Jepsen, Moritz Kebschull, France Lambert, Eduardo Montero, Nadja Naenni, Ian Needleman, Andrea Pilloni, Ausra Ramanauskaite, Mario Roccuzzo, Ignacio Sanz-Martín, Ignacio Sanz-Sánchez, Frank Schwarz, Anton Sculean, Martina Stefanini, Daniel Thoma, Leonardo Trombelli, Cristina Valles, Nicola West, Giovanni Zucchelli, Otto Zuhr, David Herrera","doi":"10.1111/jcpe.14182","DOIUrl":"https://doi.org/10.1111/jcpe.14182","url":null,"abstract":"<p><strong>Background: </strong>Aesthetics and patient-reported experiences (PREs) and outcomes (PROs) influence treatment choices, but have been largely overlooked in periodontology and implant dentistry. This consensus conference evaluated these factors by focusing on gingival recession defects (GRDs), immediate or early/delayed implant placement and peri-implant buccal soft-tissue dehiscences.</p><p><strong>Methods: </strong>The workshop discussions were informed by five specifically commissioned systematic reviews covering PREs, PROs and clinician-reported outcomes (CROs), including effectiveness, aesthetics and other concerns.</p><p><strong>Results: </strong>Following treatments such as coronally advanced flaps (CAFs) with a connective tissue graft (CTG) for root coverage (RC), a positive correlation was noted between clinician-reported aesthetic scores and RC measures for GRDs. However, a corresponding correlation for patient-reported aesthetic perceptions was not evident. In dental implant procedures, the addition of a CTG immediately after implant placement significantly mitigated the apical shift in the mid-facial mucosal level. However, clinician- and patient-reported aesthetic scores were not reflective of these changes. Neither set of scores captured the impact of grafting on improving peri-implant soft-tissue volume. In the treatment of peri-implant dehiscences, soft-tissue augmentation (STA), using CTG beneath CAF, resulted in favourable outcomes in clinician- and patient-perceived aesthetics.</p><p><strong>Conclusions: </strong>Clinician and patient views provide complementary perspectives for evidence-based clinical decision making. They need to be integrated into select interventions. Specific trials are needed encompassing PREs, PROs and CROs and reporting benefits and harms.</p>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}