{"title":"Periodontal Inflammation and Serum Inflammatory Markers in Community‐Dwelling Older Adults in Japan: The Otassha Study","authors":"Masanori Iwasaki, Maki Shirobe, Yuki Ohara, Keiko Motokawa, Takashi Shida, Yoshiko Motohashi, Ayako Edahiro, Hisashi Kawai, Yoshinori Fujiwara, Kazushige Ihara, Yutaka Watanabe, Hiroyuki Sasai, Shuichi Obuchi, Hirohiko Hirano","doi":"10.1111/jcpe.14177","DOIUrl":"https://doi.org/10.1111/jcpe.14177","url":null,"abstract":"AimTo investigate the associations between periodontal inflammation—as determined by the periodontal inflamed surface area (PISA)—and serum inflammatory markers in community‐dwelling older adults in Japan.Materials and MethodsThis cross‐sectional study included 470 adults (mean age: 73.1 years). The composite inflammatory marker <jats:italic>z</jats:italic>‐score (CIMZ) was calculated as the sum of the participants' individual <jats:italic>z</jats:italic>‐scores for C‐reactive protein (CRP), interleukin‐1beta (IL‐1β), IL‐6 and tumour necrosis factor‐α (TNF‐α). The associations of PISA (quartiles) with individual biomarkers (continuous, log‐transformed) and CIMZ (dichotomized, highest quartile or not) were assessed using linear or Poisson regression models.ResultsCompared with participants in the lowest PISA quartile (Q1), those in Q3 and Q4 had significantly (<jats:italic>p</jats:italic> < 0.05) higher CRP and IL‐6 levels. Statistically significant linear trends (<jats:italic>p</jats:italic><jats:sub>trend</jats:sub> < 0.05) across the PISA quartiles were observed for CRP and IL‐6. The multivariable adjusted prevalence ratios (95% confidence intervals) of high CIMZ (reference: Q1) were 1.20 (0.68–2.14), 1.66 (0.96–2.88) and 1.90 (1.08–3.34) (<jats:italic>p</jats:italic><jats:sub>trend</jats:sub> = 0.01) in individuals in PISA Q2–Q4.ConclusionsOlder adults with high periodontal inflammation had high serum CRP and IL‐6 concentrations and composite summary inflammatory indicator values. Periodontal inflammation is a potential modifiable factor of elevated inflammatory status among older adults in Japan.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"24 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143926288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pre‐Emptive Analgesia for Periodontal and Implant‐Related Surgery: A Systematic Review and Meta‐Analysis","authors":"Christos Gousias, Zainab Alsuwaiyan, Alissa Fial, Shengtong Han, Dimitris N. Tatakis, Vrisiis Kofina","doi":"10.1111/jcpe.14157","DOIUrl":"https://doi.org/10.1111/jcpe.14157","url":null,"abstract":"ObjectiveThis systematic review aimed to answer the question: In patients undergoing periodontal and peri‐implant surgery, gingival augmentation, implant site development or placement, are pre‐emptive analgesics effective in controlling post‐operative pain compared with patients not receiving pre‐emptive medications?Materials and MethodsAfter comprehensive electronic and manual literature searches, randomised placebo‐controlled clinical trials on adults undergoing the aforementioned surgeries were included. A meta‐analysis was performed comparing pain (standardised mean difference) between pre‐emptive medication and placebo at post‐operative hours 1, 3, 6, 8, 24 and 72.ResultsTwo reviewers screened 1995 titles, included 18 studies in the systematic review (open flap debridement, osseous, mucogingival, unspecified periodontal surgery, implant placement; 1008 patients) and 7 studies in the meta‐analysis. Non‐steroidal anti‐inflammatory drugs, acetaminophen and corticosteroids were prescribed 8 h to immediately pre‐operatively and post‐operatively until 12 h after the first dose. A clinically significant pain reduction peaked at 3 h (−0.81 [95% CI: −1.03, −0.58]; 9 study arms, <jats:italic>n</jats:italic> = 165 drug vs. <jats:italic>n</jats:italic> = 96 placebo patients) and was significant until 8 h (−0.54 [95% CI: −0.79, −0.28]; 7 study arms, <jats:italic>n</jats:italic> = 126 drug vs. <jats:italic>n</jats:italic> = 96 placebo patients), with moderate certainty of evidence (GRADE assessment).ConclusionPre‐emptive analgesia can reduce pain for up to 8 h following periodontal and implant placement surgery.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"13 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143920070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicola X. West, Alexander Gormley, Alexander J. Pollard, Rossana Izzetti, Crystal Marruganti, Filippo Graziani
{"title":"Evaluating the Performance and Implementation of the 2018 Classification of Periodontal Diseases: A Systematic Review and Survey","authors":"Nicola X. West, Alexander Gormley, Alexander J. Pollard, Rossana Izzetti, Crystal Marruganti, Filippo Graziani","doi":"10.1111/jcpe.14170","DOIUrl":"https://doi.org/10.1111/jcpe.14170","url":null,"abstract":"AimTo evaluate the performance and implementation of the 2018 Classification of Periodontal Diseases for periodontitis through systematic review and survey methodology.Materials and MethodsA two‐part systematic review was conducted. Part 1 aimed, with descriptive statistics, to evaluate performance metrics of the 2018 Classification, including diagnostic accuracy, prognostic performance and examiner reliability. Part 2 used thematic analysis to elucidate facilitators and barriers to the implementation of the classification. A survey collected evidence of barriers, facilitators and local implementation.ResultsPart 1 of this review included 14 individual studies of moderate risk of bias. Eight studies examined diagnostic accuracy, three studies examined prognostic efficacy and three studies examined inter‐/intra‐rater reliability. Part 2 included 33 individual studies with data considered at high risk of bias. The survey returned 1113 responses. The thematic analysis in Part 2 led to seven findings, five related to facilitators and two concerning barriers to the implementation. Survey results showed that 78% of respondents currently use the classification, but the most common concerns relate to its complexity.ConclusionsThe 2018 Classification performs well as a classification in comparison with previous classifications. Specific identified barriers have potentially limited the comprehensive uptake of the classification.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143920069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sebastian-Edgar Baumeister,Birte Holtfreter,Thomas Kocher,Gustavo G Nascimento
{"title":"Capitalising on Tax Variation to Estimate the Effect of Alcohol Consumption on Edentulism.","authors":"Sebastian-Edgar Baumeister,Birte Holtfreter,Thomas Kocher,Gustavo G Nascimento","doi":"10.1111/jcpe.14176","DOIUrl":"https://doi.org/10.1111/jcpe.14176","url":null,"abstract":"AIMTo estimate alcohol consumption's effect on edentulism using state alcohol taxes as an instrumental variable (IV).MATERIAL AND METHODSAnalysis of 514,357 U.S. Behavioural Risk Factor Surveillance System participants (2003-2006, 2008, 2010, 2012) linked to state alcohol taxes. We used IV regression modelling to assess the relationship between alcohol consumption and edentulism, plus potential mediators (body mass index, dental visits) and a positive control (coronary heart disease). Robustness to imperfect exogeneity was evaluated through sensitivity analyses and falsification testing using IV analysis on individuals under the age of 16 years.RESULTSA 1.1-drink increment per day was associated with a 12% higher risk of edentulism (95% confidence interval: 9%-16%). Alcohol consumption was positively associated with body mass index, dental visits and coronary heart disease. No significant effect on edentulism was observed in the negative control population (individuals aged < 16 years).CONCLUSIONThe findings of this quasi-experimental study suggest that alcohol consumption increases the risk of edentulism.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"9 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143914930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David Herrera, Maurizio S. Tonetti, Iain Chapple, Moritz Kebschull, Panos N. Papapanou, Anton Sculean, Loreto Abusleme, Mario Aimetti, Georgios Belibasakis, Juan Blanco, Nagihan Bostanci, Philippe Bouchard, Nurcan Buduneli, Elena Calciolari, Maria Clotilde Carra, Tali Chackartchi, Bettina Dannewitz, Monique Danser, Coral Deng, Jan Derks, Thomas Dietrich, Nicola Discepoli, Kimon Divaris, Henrik Dommisch, Nikos Donos, Nicolás Dutzan, Peter Eickholz, Bahar Eren Kuru, Ricardo Faria Almeida, Roberto Farina, Balazs Feher, Elena Figuero, William Giannobile, Marjolaine Gosset, Filippo Graziani, Ulvi K. Gursoy, Daniel Hagenfeld, Karin Jepsen, Sören Jepsen, Purnima Kumar, Marja L. Laine, France Lambert, Niklaus P. Lang, Yuan Li, Bruno Loos, Phoebus Madianos, Paula Matesanz, Brian Mealey, Ana Molina, Eduardo Montero, Luigi Nibali, Philip Preshaw, Mia Rakic, Christoph Ramseier, Giovanni Salvi, Nerea Sánchez, Ignacio Sanz‐Sánchez, Lior Shapira, Andreas Stavropoulos, Faleh Tamimi, Wim Teughels, Cristiano Tomasi, Leonardo Trombelli, Spyros Vassilopoulos, Anders Verket, Nicola West, Peter Windisch, Mariano Sanz
{"title":"Consensus Report of the 20th European Workshop on Periodontology: Contemporary and Emerging Technologies in Periodontal Diagnosis","authors":"David Herrera, Maurizio S. Tonetti, Iain Chapple, Moritz Kebschull, Panos N. Papapanou, Anton Sculean, Loreto Abusleme, Mario Aimetti, Georgios Belibasakis, Juan Blanco, Nagihan Bostanci, Philippe Bouchard, Nurcan Buduneli, Elena Calciolari, Maria Clotilde Carra, Tali Chackartchi, Bettina Dannewitz, Monique Danser, Coral Deng, Jan Derks, Thomas Dietrich, Nicola Discepoli, Kimon Divaris, Henrik Dommisch, Nikos Donos, Nicolás Dutzan, Peter Eickholz, Bahar Eren Kuru, Ricardo Faria Almeida, Roberto Farina, Balazs Feher, Elena Figuero, William Giannobile, Marjolaine Gosset, Filippo Graziani, Ulvi K. Gursoy, Daniel Hagenfeld, Karin Jepsen, Sören Jepsen, Purnima Kumar, Marja L. Laine, France Lambert, Niklaus P. Lang, Yuan Li, Bruno Loos, Phoebus Madianos, Paula Matesanz, Brian Mealey, Ana Molina, Eduardo Montero, Luigi Nibali, Philip Preshaw, Mia Rakic, Christoph Ramseier, Giovanni Salvi, Nerea Sánchez, Ignacio Sanz‐Sánchez, Lior Shapira, Andreas Stavropoulos, Faleh Tamimi, Wim Teughels, Cristiano Tomasi, Leonardo Trombelli, Spyros Vassilopoulos, Anders Verket, Nicola West, Peter Windisch, Mariano Sanz","doi":"10.1111/jcpe.14152","DOIUrl":"https://doi.org/10.1111/jcpe.14152","url":null,"abstract":"BackgroundThis Consensus Workshop dealt with diagnostic methodologies in the context of surveillance, screening, assessment of stage and grade, prognosis, monitoring and prediction of periodontal status. Several elements provided the impetus for the workshop, including the limited quality of available research on diagnostic tests, the rapid development of new technologies, the implementation of the 2018 classification and the declarations of the World Health Organisation on diagnosis and oral health.AimTo update and evaluate the evidence on diagnostic methods, considering recent advances in knowledge and the implementation of the 2018 classification.MethodsThe European Workshop Committee of the European Federation of Periodontology guided the development of a consensus report after commissioning eight systematic reviews within three working groups. The reviews were discussed during the in‐person consensus meeting involving 70 participants from 21 different countries.ResultsWorking Group 1 discussed innovations in traditional diagnostic approaches, justified manual probing as the reference standard and assessed the value of image‐based methods. Working Group 2 analysed diagnostic tests based on microbial and host biomarkers and genetic diagnostic tests. Working Group 3 covered emerging technologies to be used within dental and non‐dental clinical settings, focusing principally on the impact of questionnaire‐based assessments and artificial intelligence systems (AIS) in interpreting different data modalities.ConclusionAlthough manual periodontal probing is firmly established as the reference standard, additional approaches based on imaging, biomarkers, host genetics, questionnaires and the development of emerging applied data science methods (e.g., AIS) are increasingly integrated in periodontal diagnostics.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"113 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143905813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mario Romandini, Cristina Lima, Miguel Moreno, Mariano Sanz
{"title":"Accuracy of Clinical Parameters in Predicting/Diagnosing Peri‐Implant Bone Loss","authors":"Mario Romandini, Cristina Lima, Miguel Moreno, Mariano Sanz","doi":"10.1111/jcpe.14095","DOIUrl":"https://doi.org/10.1111/jcpe.14095","url":null,"abstract":"AimTo determine whether clinical parameters can serve as (i) predictive tools (before occurrence) and (ii) diagnostic tools (after occurrence) of peri‐implant bone loss.Materials and MethodsA representative cohort of 72 patients with 298 implants was evaluated at baseline and after a mean follow‐up period of 3.9 years. Peri‐implant bone loss > 1 mm between the two examinations represented the reference standard. The accuracy of the following clinical parameters in predicting (at baseline) or diagnosing (at follow‐up) peri‐implant bone loss was assessed: presence of bleeding (BoP) or suppuration (SoP) on probing, visual signs of redness or swelling, BoP extent (number of sites with BoP) and severity (modified Bleeding Index—mBI), probing pocket depth (PPD) at various cut‐offs, peri‐implant soft‐tissue dehiscence (PISTD) and changes in PPD/PISTD over time. Predictive/diagnostic performance was evaluated using mixed model logistic regression analyses and reporting sensitivity, specificity, positive/negative predictive values and area under the curve (AUC) values.ResultsBone loss > 1 mm was observed in 9.4% of implants and was frequently preceded by BoP (sensitivity = 96.4%; specificity = 7.4%). At follow‐up, bone loss was always associated with the concomitant presence of BoP (sensitivity = 100.0%; specificity = 14.4%).In predicting the future occurrence of peri‐implant bone loss, high sensitivity (94.4%) was also noted for visual redness at baseline, although its specificity was low (25.9%). Conversely, high specificity but low sensitivity was observed for BoP at 6 sites (sensitivity = 25.0%; specificity = 88.1%) and SoP (sensitivity = 14.3%; specificity = 91.5%).For diagnosing recent peri‐implant bone loss, high specificity was noted for SoP (100.0%), profuse bleeding (91.9%), BoP at 6 sites (87.0%), PPD ≥ 6 mm (81.9%), changes in PPD (95.9%) and changes in PISTD (91.5%). However, all these parameters showed limited sensitivity. The best diagnostic accuracy was achieved using a combined criterion of site‐specific PPD or PISTD increases > 1 mm over time (sensitivity = 82.1%; specificity = 70.0%; AUC = 0.76).ConclusionsClinical signs considered indicative of peri‐implant mucositis (presence of BoP, visual redness) usually precede peri‐implant bone loss. Implants with a recent history of bone loss always present with concomitant BoP. However, the predictive/diagnostic value of detecting one or two spots of BoP is limited by its low specificity. Implants with BoP at six sites or SoP are more likely to exhibit bone loss over time. During follow‐up, BoP at six sites, profuse bleeding, SoP, PPD ≥ 6 mm, or increases in PPD/PISTD over time have high specificity for diagnosis of recent peri‐implant bone loss.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"1 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143905739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matthijs Hindryckx,Thomas De Bruyckere,Stefanie De Buyser,Lorenz Seyssens,Retis Shtino,Faris Younes,Jan Cosyn
{"title":"A Multi-Centre Randomised Controlled Trial Comparing dPTFE Membrane to Collagen Membrane in Lateral Bone Augmentation at Single Sites in the Anterior Maxilla: 1-Year Results.","authors":"Matthijs Hindryckx,Thomas De Bruyckere,Stefanie De Buyser,Lorenz Seyssens,Retis Shtino,Faris Younes,Jan Cosyn","doi":"10.1111/jcpe.14174","DOIUrl":"https://doi.org/10.1111/jcpe.14174","url":null,"abstract":"AIMTo compare a dense polytetrafluoroethylene (dPTFE) membrane with a collagen membrane in guided bone regeneration for lateral bone augmentation at single sites in the anterior maxilla in terms of alveolar width, height, complications, need for additional therapy and implant outcomes.MATERIALS AND METHODSPatients with a class 4 defect at a single site in the anterior maxilla (15-25) were recruited at five centres. Following flap elevation and conditioning of the recipient site, they were randomly allocated to the dPTFE membrane group or the collagen membrane group. Nine months following bone augmentation, re-entry was performed and implants were placed. Alveolar dimensions were assessed on superimposed cone-beam computed tomography images taken prior to surgery, immediately post operation and at 9 months. Implant outcomes were registered 1 year after bone augmentation.RESULTSThirty-six patients were randomised (dPTFE membrane group: 8 females, 10 males, mean age 39; collagen membrane group: 14 females, 4 males, mean age 51) and all complied until the 1-year follow-up. At 9 months, the estimated marginal mean alveolar width was not significantly different between the groups (estimated marginal mean difference at 3 mm below the crest: 0.65 mm; 95% CI: -0.82 to 2.12; p = 0.381). Infection occurred in 6/18 patients treated with a dPTFE membrane and in 0/18 patients treated with a collagen membrane (p = 0.019). Infection occurred in every centre and had a negative impact on the alveolar width at 9 months, despite taking anti-infective measures in every patient and additional bone augmentation in two patients. Implants could be installed in a prosthetically driven position, integrated uneventfully and yielded minimal marginal bone loss.CONCLUSIONdPTFE membrane and collagen membrane are both effective in lateral bone augmentation. However, dPTFE membrane is more prone to infection than collagen membrane, thereby increasing the need for additional therapy.TRIAL REGISTRATIONClinicalTrials.gov identifier: NCT05426616.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"67 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}