Journal of Clinical Periodontology最新文献

{"title":"Cost Effectiveness of Two Short Implants Versus One Short Implant With a Cantilever in the Posterior Region: 7.5-Year Follow-Up of a Randomised Controlled Trial.","authors":"Franz J Strauss,Lucia Schiavon,Nadja Naenni,Riccardo D Kraus,Gustavo Sáenz-Ravello,Nicolas Müller,Ronald E Jung,Daniel S Thoma","doi":"10.1111/jcpe.70039","DOIUrl":"https://doi.org/10.1111/jcpe.70039","url":null,"abstract":"AIMTo compare long-term clinical and radiographic outcomes of a single short implant (6 mm) supporting a cantilevered restoration versus two adjacent short implants with non-splinted single crowns over a 7.5-year follow-up and determine which approach is more cost effective.MATERIALS AND METHODSA total of 36 patients with at least a two-tooth gap in the posterior region were randomised to receive either one short implant with a cantilever prosthesis (ONE-C) or two short implants with individual crowns (TWO). Fixed restorations were placed 3-6 months post implantation, and patients were evaluated at baseline and at 6 months and 1, 3, 5 and 7.5 years. Kaplan-Meier curves, mixed-effects models and cost-effectiveness models were used to compare the groups.RESULTSTwenty-five patients (15 in ONE-C, 10 in TWO) completed the 7.5-year follow-up. Implant survival was 83.3% in group ONE-C and 86.6% in group TWO, with no significant differences between the groups (p = 0.772). No statistically significant differences were found between groups for marginal bone levels (mean difference -0.16 [95% CI: -0.7 to 0.3] p = 0.57), probing depth (mean difference -0.13 [95% CI: -0.5 to 0.3] p = 0.58), bleeding on probing (mean difference 0.0 [95% CI: -0.0; 0.2] p = 0.31) or plaque levels (mean difference -0.0 [95% CI: -0.1 to 0.1] p = 0.93). Technical complications were more frequent in the ONE-C group (64%) than in the TWO group (36%).CONCLUSIONBoth treatment approaches showed comparable clinical and radiographic outcomes. Short implants supporting cantilever restorations were generally more cost effective than two short implants but exhibited higher early complication and failure rates, likely related to mechanical overload.TRIAL REGISTRATIONClinicalTrials.gov Identifier: NCT01649531.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"22 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of Robotic Computer-Assisted Implant Surgery Combined With Transcrestal Sinus Floor Elevation for Single-Tooth Implants: A Retrospective Case Series.","authors":"Jieyong Jia,Liangzhi Du,Longlong He,Zhe Li,Yuncong Li,Chengpeng Lv","doi":"10.1111/jcpe.70038","DOIUrl":"https://doi.org/10.1111/jcpe.70038","url":null,"abstract":"AIMTo evaluate the accuracy and safety of robotic computer-assisted implant surgery (r-CAIS) for transcrestal sinus floor elevation (TSFE) in single-tooth implant placement.MATERIALS AND METHODSIn this retrospective case series, we assessed the positional accuracy of r-CAIS combined with TSFE in the posterior maxilla. Preoperative and postoperative cone-beam computed tomography (CBCT) scans were used to determine implant positioning accuracy. Subgroup analyses evaluated the effects of various factors on accuracy. Additionally, complications were recorded and evaluated.RESULTSA total of 40 patients and 40 implants were included. Only one case (Case XIX) exhibited a Schneiderian membrane perforation, resulting in a perforation rate of 2.5% (1/40). The mean global coronal and apical deviations were 0.50 ± 0.22 mm and 0.54 ± 0.21 mm, respectively, with an angular deviation of 1.25° ± 0.61°. A linear mixed model (LMM) analysis revealed no statistically significant differences between subgroups (implant position, side of arch, bone quality, implant type, implant size and registration method) and implant deviations (p > 0.05).CONCLUSIONSr-CAIS showed excellent accuracy and safety for TSFE in single-tooth implant placement. This study suggests r-CAIS can achieve favourable clinical outcomes, although further clinical evidence is needed to confirm its broader efficacy.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"38 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145083475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of the Probiotic Limosilactobacillus reuteri as an Adjunct to Subgingival Instrumentation in the Treatment of Periodontitis Patients With Diabetes: A Randomised Clinical Trial.","authors":"Rocío Bujaldón,Eduardo Montero,Juan Daniel Gamonal,Alejandro Abuelo,María José Marín,Margarita Iniesta,Mariano Sanz,David Herrera","doi":"10.1111/jcpe.70035","DOIUrl":"https://doi.org/10.1111/jcpe.70035","url":null,"abstract":"AIMTo evaluate the clinical and microbiological effects of a Limosilactobacillus reuteri-based probiotic as an adjunct to subgingival instrumentation in untreated periodontitis patients with diabetes.METHODSA 6-month, randomised, triple-blinded clinical trial was conducted involving 40 patients, receiving steps 1 and 2 of periodontal therapy, including subgingival instrumentation, and randomised to receive tablets containing L. reuteri or placebo, for 3 months. Clinical and microbiological outcomes as well as glycosylated haemoglobin (HbA1c) concentrations were evaluated at baseline and at 3 and 6 months after therapy.RESULTSAt 6 months, both groups showed statistically significant reductions in the primary outcome (mean probing depth), with reductions of 0.9 mm in the probiotic group and 0.8 mm in the placebo group, with no significant differences between them. Both groups exhibited reductions in HbA1c levels after 6 months, more in the probiotic group (-0.6% vs. -0.1%), with statistically significant inter-group differences (-0.5%; 95% confidence interval [-1.0; 0.0]; p < 0.001). Microbiological outcomes were similar.CONCLUSIONSThe adjunctive use of a L. reuteri-based probiotic did not provide additional clinical or microbiological benefits, compared to placebo, following subgingival instrumentation in patients with periodontitis and diabetes. However, statistically significant differences in HbA1c levels were observed, with larger reductions in the probiotic group, suggesting a potential systemic benefit.TRIAL REGISTRATIONThe protocol was approved by the Clinical Research Ethics Committee (CEIC) of Hospital Clínico de San Carlos (internal code 19/101-R_X) and registered a priori in ClinicalTrials.gov (identifier NCT04069611).","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"50 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145071650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacovigilance-Based Identification and Mechanistic Exploration of Periodontitis-Related Drugs.","authors":"Wuda Huoshen,Junkai Xiong,Xunmi Ma,Heng Wang,Panyu Cheng,Xinyu Chen,Ge Shuai,Yi Chen,Xinyue Zhang,Chen Sun,Chunhui Li,Rui Shi","doi":"10.1111/jcpe.70040","DOIUrl":"https://doi.org/10.1111/jcpe.70040","url":null,"abstract":"BACKGROUNDPeriodontitis is a common chronic inflammatory disease. However, drug-related risks and underlying molecular mechanisms remain underexplored from large real-world data.METHODSWe first mined the US Food and Drug Administration Adverse Event Reporting System (FAERS) database to identify drugs disproportionately associated with periodontitis, using four signal detection algorithms and logistic regression for confounder adjustment. Identified drugs were then mapped to their protein targets via DrugBank, followed by pathway enrichment and protein-protein interaction (PPI) network analysis to explore biological relevance. To assess potential causality, we conducted Mendelian randomisation (MR) using cis-pQTLs from UKB-PPP and deCODE cohorts. Finally, we used single-cell RNA sequencing (scRNA-seq) data from gingival tissue and peripheral blood of periodontitis patients to evaluate cell type-specific expression of candidate causal genes.RESULTSFive drugs (actonel, aclasta, aredia, amlodipine and avastin) were significantly positively associated with periodontitis based on FAERS. VEGFA showed an association with disease risk (OR = 1.043, p = 0.049) after meta-analysis of two cohorts. scRNA-seq data identified high VEGFA expression in monocytes in both gingival and blood samples of periodontitis patients.CONCLUSIONThis study uncovered the association between drug and periodontitis and highlighted VEGFA as a potential molecular mediator. Further studies are needed to confirm causality.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"9 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145071651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prosthetic Outcomes in Stage III/IV Periodontitis Patients With 20-29 Years of Supportive Periodontal Care.","authors":"T Eger,F Wörner,N Lingwal,P Eickholz","doi":"10.1111/jcpe.70036","DOIUrl":"https://doi.org/10.1111/jcpe.70036","url":null,"abstract":"OBJECTIVETo assess (i) tooth loss (TL) in treated periodontitis (stage III/IV) patients undergoing supportive periodontal care without or with partial denture (PD) (removable [RPD], fixed PD [FPD], implant supported FPD [iFPD]) and (ii) 10-year prosthetic outcomes.METHODSFrom 1993 to 2023, comprehensive periodontal therapy including restorative treatment was rendered at the Bundeswehr Central Hospital periodontology outpatient clinic.RESULTSTwo-hundred and thirty-three patients with generalised stage III/IV periodontitis were treated with a mean follow-up of 21.7 ± 2.7 years: 12 with 21 clasp-retained metal-based RPDs (TL/year 0.4 ± 0.39), 12 with 20 double crown-retained metal-based RPDs (0.35 ± 0.42), 50 with 80 ≥ 5-unit FPD (0.23 ± 0.33) and 27 with 218 implants (0.15 ± 0.22). One-hundred and thirty-two patients with < 5-unit FPDs, no RPDs or iFPDs served as control. The control group exhibited the lowest rate of TL (0.05 ± 0.08). Multivariate analyses revealed age (p < 0.001), smoking > 10 cigarettes/day (p < 0.001) and RPD (p = 0.002)/FPD (p < 0.001) but not iFPD (p = 0.134) to be significantly associated with TL. After 10 years, in 75% patients 67% of the metal-based clasp-retained RPDs; in 80% of patients 75% of double crown RPDs; in 90% of patients 93% of FPD; and in 76% of patients 83% of iFPDs were functional.CONCLUSIONStage III/IV periodontitis patients treated with RPD and FPD have a higher long-term TL rate than controls and iFPD.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"36 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145068433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the Diabetes Risk Assessment in Dentistry Score in NHANES 2009-2014.","authors":"Carlota Rodrigues,Vanessa Machado,Luís Proença,José João Mendes,Thomas Kocher,Birte Holtfreter,Zehra Yonel,João Botelho","doi":"10.1111/jcpe.70037","DOIUrl":"https://doi.org/10.1111/jcpe.70037","url":null,"abstract":"AIMTo validate the Diabetes Risk Assessment in Dentistry Score (DDS) in a US population-based sample and compare its performance with the American Diabetes Association (ADA) risk calculator and the Leicester Risk Assessment (LRA).METHODSData were obtained from the National Health and Nutrition Examination Survey (NHANES) covering the 2009-2014 cycles. The study focused on participants aged 40 years and older who included complete data for DDS and ADA risk score assessment. Model performance was evaluated using the area under the receiver operating characteristic curve (AUC), while decision curve analysis (DCA) was used to evaluate the clinical utility of the model.RESULTSOf the 6259 participants included, the average age was 57.3 years (±12.0 years, range: 40-80 years) and the sample was evenly distributed by sex (50.8% female). DDS showed limited discriminative ability with an AUC of 0.64 (95% confidence interval [CI]: 0.62-0.65), and DCA analysis showed higher net benefit than the 'Treat None' strategy across most probability thresholds, indicating added clinical value in decision making. The ADA risk calculator and LRA showed an AUC of 0.61 (95% CI: 0.59-0.63) and 0.631 (95% CI: 0.615-0.647), which were below the DDS performance.CONCLUSIONThe DDS demonstrated acceptable performance for American adults aged 40 years or older, and showed marginally superior performance compared with the ADA diabetes risk calculator and LRA, highlighting its potential utility in dental practice settings as a complementary screening tool.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"35 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145059090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra-Processed Foods Reduction Enhances Clinical Outcomes and Dietary Profiles in Patients With Gingivitis: Results From a Randomised Controlled Trial.","authors":"Nicola Discepoli,Isabella De Rubertis,Giulia Tavella,Arianna Guazzelli,Styliani Konstantinidou,Barbara Paolini","doi":"10.1111/jcpe.70034","DOIUrl":"https://doi.org/10.1111/jcpe.70034","url":null,"abstract":"AIMTo evaluate the impact of ultra-processed foods reduction advice (UPF-RA) on gingivitis treatment and dietary patterns.METHODSYoung adults with gingivitis were randomly assigned to two groups. At baseline, test group participants received UPF-RA. At 8 weeks, professional mechanical plaque removal (PMPR) was carried out, followed by UPF-RA (test group only). Full-mouth periodontal charting and dietary data, collected through the NOVA Food Frequency Questionnaire and the Medi-Lite, were recorded at baseline and at 8 and 16 weeks.RESULTSSixty-six patients (mean age: 23.3 ± 2.3 years; 32 males and 34 females) were included. At 8 weeks, a significant reduction in full-mouth bleeding score (FMBS) was observed in the test group (18.9% ± 8.6% to 14.6% ± 9.0%; p = 0.04), with a concomitant decrease in UPF intake (912.7 ± 511.3 kcal to 446.9 ± 264.6 kcal; p < 0.001). No significant changes in FMBS and UPF consumption were observed in the control group (19.8% ± 9.0% to 19.1% ± 8.6%, p = 0.93; 776.4 ± 453.6 kcal to 775.3 ± 451.03, p = 1.00, respectively). At 16 weeks, gingivitis was resolved in 24% more cases in the test group. Logistic regression identified low UPF intake and UPF-RA as significant predictors of FMBS reduction.CONCLUSIONSReduction in UPF consumption improved gingivitis treatment outcomes and participants' dietary quality. Patients with higher UPF consumption showed higher bleeding scores.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"15 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145059089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stability of Root Coverage Outcomes After Soft‐Tissue Augmentation With a Collagen Matrix With or Without rhPDGF‐BB: A 3‐Year Triple‐Blinded, Randomised, Placebo‐Controlled Trial","authors":"Lorenzo Tavelli, Shayan Barootchi, Maria Vera Rodriguez, Leonardo Mancini, Hamoun Sabri, Tu Nguyen, Jad Majzoub, Suncica Travan, William V. Giannobile","doi":"10.1111/jcpe.70030","DOIUrl":"https://doi.org/10.1111/jcpe.70030","url":null,"abstract":"AimTo evaluate the 3‐year stability of root coverage outcomes following treatment with a coronally advanced flap (<jats:styled-content style=\"fixed-case\">CAF</jats:styled-content>) and a volume‐stable, cross‐linked xenogeneic collagen matrix (<jats:styled-content style=\"fixed-case\">VCMX</jats:styled-content>), either soaked in recombinant human platelet–derived growth factor‐<jats:styled-content style=\"fixed-case\">BB</jats:styled-content> (<jats:styled-content style=\"fixed-case\">rhPDGF</jats:styled-content>, test arm) or sterile saline (control arm).MethodsOf the original 30 participants in the triple‐blind, randomised, placebo‐controlled trial, 26 were available for follow‐up at 1 and 3 years. The primary outcome was mean root coverage (<jats:styled-content style=\"fixed-case\">mRC</jats:styled-content>) at 3 years compared to the 6‐month results. Secondary outcomes included complete root coverage, keratinised tissue width, gingival thickness, volumetric and aesthetic changes, patient‐reported outcome measures (<jats:styled-content style=\"fixed-case\">PROMs</jats:styled-content>) and ultrasonographic tissue properties. Untreated contralateral teeth were also assessed.ResultsFrom 6 months to 3 years, <jats:styled-content style=\"fixed-case\">mRC</jats:styled-content> decreased by 6.7% in the control arm and 7.5% in the test arm (<jats:italic>p</jats:italic> &gt; 0.05). Over 90% of treated sites maintained a stable gingival margin (≤ 0.5 mm shift). No significant inter‐group differences were found for volumetric, aesthetic or <jats:styled-content style=\"fixed-case\">PROM</jats:styled-content> outcomes. Ultrasonography revealed increased tissue elasticity in treated sites. In contrast, untreated contralateral sites showed progressive gingival recession and increased hypersensitivity (<jats:italic>p</jats:italic> &lt; 0.001).ConclusionBoth <jats:styled-content style=\"fixed-case\">VCMX</jats:styled-content> treatments demonstrated stable clinical and ultrasonographic outcomes over 3 years, while untreated sites showed signs of soft‐tissue deterioration.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"45 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145035129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D Method for the Volumetric Evaluation and Visualisation of Dental Biofilms: A Proof-of-Principle Study.","authors":"Katja Povšič,Haris Munjaković,Vanja Erčulj,Aleš Fidler,Rok Gašperšič","doi":"10.1111/jcpe.70019","DOIUrl":"https://doi.org/10.1111/jcpe.70019","url":null,"abstract":"BACKGROUND AND OBJECTIVETraditional and planimetric plaque indices rely on plaque-disclosing agents and cannot quantify three-dimensional (3D) structures of dental biofilms. We introduce a novel computer-assisted method for evaluating and visualising plaque volume using intraoral scans (IOSs).MATERIALS AND METHODSThis was a 4-day, non-brushing, plaque-regrowth study (n = 15). All plaque was removed at baseline (T0). IOSs at T0 and after 4 days (T4) were used for volumetric plaque assessment in six steps: model acquisition, model superimposition, computer-aided determination of tooth-surface margins, tooth-surface superimposition, visualisation and volumetric evaluation of biofilms. Plaque formation at T4 was additionally assessed with the Turesky Modification of the Quigley-Hein Plaque Index (TMQHPlI). We used Pearson's correlation coefficients and multilevel models to investigate the relationships between TMQHPlI, volumetric plaque index (VPI) and the adjusted volumetric plaque index (AVPI, plaque volume/area).RESULTSVPI and AVPI positively correlated with the TMQHPlI, showing higher variability at lower TMQHPlI scores. VPI had a lower threshold for plaque detection and higher sensitivity than the TMQHPlI. VPI and TMQHPlI were highest on vestibular, maxillary and molar surfaces.CONCLUSIONVPI quantifies biofilm deposits, is a more precise measure for plaque detection than the TMQHPlI and can be visualised using colour-coded maps displaying areas of equal plaque thickness.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"26 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parkin Acetylation-Mediated Mitophagy Orchestrates Periodontal Ligament Stem Cell Osteogenesis and Bone Regeneration During Ageing.","authors":"Kehan Zhang,Xiangyao Wang,Yuxiao Zhang,Yuanyuan Li,Yaxin Wu,Gaoshaer Nuerlan,Qilin Li,Jing Mao,Shiqiang Gong,Yan Liu","doi":"10.1111/jcpe.70031","DOIUrl":"https://doi.org/10.1111/jcpe.70031","url":null,"abstract":"AIMTo investigate the functional significance of mitophagy in age-related osteogenic decline and the underlying mechanisms using in vivo and in vitro models.MATERIALS AND METHODSAn alveolar bone defect model in aged mice and a serial passaging-induced ageing model of human periodontal ligament stem cells (PDLSCs) were established. Osteogenic potential in mice was assessed by micro-CT, immunofluorescence, immunohistochemical analyses and histological staining. Osteogenic differentiation, mitochondrial function and mitophagy in PDLSCs were assessed using molecular techniques, cytochemical assays and imaging approaches. HDAC2-Parkin interactions and Parkin acetylation status were examined by mass spectrometry and immunoprecipitation to uncover key mechanisms.RESULTSSenescent PDLSCs exhibited impaired mitophagy and osteogenic capacity. Enhancing mitophagy restored osteogenesis of senescent PDLSCs and bone regeneration in aged mice. Mechanistically, HDAC2-mediated deacetylation of Parkin suppressed mitophagy and osteogenesis during ageing.CONCLUSIONActivation of mitophagy reverses age-associated declines in osteogenic function, highlighting mitophagy as a therapeutic target for enhancing bone repair in the ageing population.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"15 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}