Journal of Clinical Periodontology最新文献

{"title":"Impact of Keratinized Mucosa Width and Mucosal Thickness on Implant Outcomes and Brushing Discomfort: A 25-Year Cohort Study","authors":"Emilio Couso-Queiruga,&nbsp;Clemens Raabe,&nbsp;Andrea Roccuzzo,&nbsp;Giovanni E. Salvi,&nbsp;Manrique Fonseca,&nbsp;Vivianne Chappuis","doi":"10.1111/jcpe.70187","DOIUrl":"10.1111/jcpe.70187","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To assess the impact of keratinized mucosa width (KMW) and mucosal thickness (MT) on peri-implant conditions over 25 years in patients with adequate oral hygiene enrolled in regular supportive peri-implant care.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Partially edentulous patients rehabilitated with tissue-level implants were clinically and radiographically evaluated by calibrated examiners. Patient-reported brushing discomfort was recorded, and associations with variables of interest were analysed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 149 patients, 235 implants, with a mean follow-up of 25.4 ± 3 years, were included. Peri-implantitis prevalence was 11.1%, 0% and 7.1% in the 0-mm, &lt; 2-mm and ≥ 2-mm KMW groups, respectively (<i>p</i> = 0.98). Sites with 0 mm KMW showed significantly greater crestal bone loss (CBL) than &lt; 2 mm (−0.28 mm) and ≥ 2 mm (−0.40 mm) (<i>p</i> = 0.01). Absence of KMW was associated with an increased risk of peri-implant soft-tissue dehiscence (PSTD) and implant platform visibility (<i>p</i> ≤ 0.01). No significant differences were observed for probing depth (PD), bleeding on probing (BOP), plaque index or peri-implant diseases (<i>p</i> &gt; 0.05). MT was not associated with CBL, PD, BOP, suppuration on probing (SOP) or peri-implant diseases (<i>p</i> &gt; 0.05). Thin MT (&lt; 2 mm) was linked to increased PSTD (<i>p</i> = 0.005), greater implant platform visibility (<i>p</i> = 0.04) and lower plaque index (<i>p</i> = 0.01). Brushing discomfort was reported in 11.4% of sites with 0 mm KMW, compared with 3.4% and 2.4% in the &lt; 2 mm and ≥ 2 mm groups, respectively, with no significant associations across KMW or MT groups (<i>p</i> &gt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>KMW was associated with long-term peri-implant tissue stability, whereas thin MT was primarily associated with an increased risk of PSTD. Neither KMW nor MT was significantly associated with long-term brushing discomfort.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 11","pages":"1691-1701"},"PeriodicalIF":8.3,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70187","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148682126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood Famine Exposure and Late-Life Edentulism: Evidence From Natural Experiments","authors":"Sebastian-Edgar Baumeister,&nbsp;Colman McGrath,&nbsp;Thomas Kocher,&nbsp;Gustavo G. Nascimento","doi":"10.1111/jcpe.70190","DOIUrl":"10.1111/jcpe.70190","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To examine whether childhood famine exposure affects late-life edentulism using natural experiments from Asia, Europe and America.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>We utilised historical famines as exogenous shocks. Data were pooled from 10 population-based studies across eight countries (165,586 participants). Because the famine-exposed cohort is older at survey than the comparison cohort, we separated famine exposure from the birth-cohort age gradient using a regression discontinuity in time, an interrupted time series, a region-of-birth famine-intensity difference-in-differences, a pre-famine comparison cohort and applied negative controls.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The crude positive association (risk ratio [RR] 1.69) was eliminated after adjustment for current age (RR 1.07, 95% confidence interval (CI) 0.92–1.23), and the famine cohort did not differ from the older pre-famine cohort (RR 0.97). The regression discontinuity (+0.13% points, 95% CI: −1.50 to +1.77), interrupted time series (−4.01% points, <i>p</i> = 0.15) and the region-of-birth difference-in-differences in the two Chinese cohorts (unadjusted, both <i>p</i> ≥ 0.07) were null, as were all negative controls.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Once the birth-cohort age gradient is accounted for, childhood famine exposure shows no detectable effect on late-life edentulism; the crude positive association is largely explained by age confounding, which cross-sectional famine-cohort comparisons do not address.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 11","pages":"1673-1680"},"PeriodicalIF":8.3,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70190","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148754576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autotaxin/Lysophosphatidic Acid Axis Promotes Periodontitis by Modulating Macrophage Osteoclastogenesis and Inflammation","authors":"Enyan Liu,&nbsp;Jiacheng Ding,&nbsp;Yiting Jiang,&nbsp;Yining Zhou,&nbsp;Lina Xu,&nbsp;Zhiyan He,&nbsp;Wei Zhou,&nbsp;Zhongchen Song","doi":"10.1111/jcpe.70174","DOIUrl":"10.1111/jcpe.70174","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To investigate the mechanism of the autotaxin/lysophosphatidic acid (ATX/LPA) axis in regulating osteoclastogenesis and inflammation in periodontitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>The expression levels and clinical relevance of the ATX/LPA axis were studied by collecting clinical samples including gingiva and gingival crevicular fluid from periodontitis patients and healthy subjects. Subsequently, macrophage <i>Atx</i> knockout (CKO) mice and bone marrow–derived macrophages (BMDMs) were generated to investigate the role of the ATX/LPA axis in modulating osteoclastogenesis and inflammation during periodontitis development. Finally, the ATX inhibitor PF8380 was used to explore a promising therapeutic strategy for controlling periodontitis. Histomorphological, molecular and cytological analyses were performed using RNA sequencing, real-time polymerase chain reaction, immunofluorescence, immunohistochemistry, enzyme-linked immunosorbent assay, micro-computed tomography, haematoxylin and eosin staining, tartrate-resistant acid phosphatase staining, actin filament staining, pit resorption assay and flow cytometry.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The expression of the ATX/LPA axis was more enhanced in the periodontitis group than that in the health group and was positively correlated with the severity of periodontitis. Subsequently, CKO mice showed milder inflammation and less bone resorption than wild-type (WT) mice of periodontitis. Following \u0000 <i>Porphyromonas gingivalis</i>\u0000 LPS stimulation, CKO-BMDMs were markedly suppressed in osteoclastogenesis and inflammation compared to WT-BMDMs. In addition, the mechanism of the ATX/LPA axis in regulating osteoclastogenesis may act synergistically with activated inflammation-related pathways by RNA sequencing. Finally, we used the ATX inhibitor PF8380 and found that PF8380 alleviated alveolar bone resorption in periodontitis mice and modulated BMDMs' osteoclast differentiation and phenotypic transformation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The ATX/LPA axis plays a significant regulatory role in osteoclastogenesis and osteoclast activity and may enable selective control of bone loss and inflammation in periodontitis. Therefore, targeting ATX inhibition may represent a novel therapeutic strategy for preventing alveolar bone resorption and periodontal inflammation in patients with periodontitis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 11","pages":"1735-1747"},"PeriodicalIF":8.3,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148726418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontal Treatment Restores Gingival Crevicular Fluid and Serum Periostin Levels","authors":"Aysegul Sarı, Oguzhan Ozcan, Filiz Kaçmaz, Anton Sculean, Alpdogan Kantarci","doi":"10.1111/jcpe.70206","DOIUrl":"https://doi.org/10.1111/jcpe.70206","url":null,"abstract":"Background and Aim To investigate the effect of periodontal treatment on periodontal inflammation and periostin levels in patients with severe periodontitis. Methods This study included two groups (periodontitis and periodontally healthy), each comprising 24 individuals. Periodontal clinical parameters were recorded, and serum samples were collected at baseline and on Days 30 and 90 following non‐surgical periodontal treatment (NSPT). Gingival crevicular fluid (GCF) samples were collected at baseline and on Days 1, 2, 14, 30 and 90 following NSPT. Periostin, interleukin‐1 beta (IL‐1β) and fibroblast growth factor‐2 (FGF‐2) levels were assessed in serum and GCF samples. Results Clinical periodontal parameters decreased from baseline to Days 30 and 90 after NSPT ( <jats:italic>p</jats:italic> = 0.001). Patients with periodontitis had higher levels of IL‐1β in serum ( <jats:italic>p</jats:italic> = 0.020) and GCF ( <jats:italic>p</jats:italic> = 0.001) than healthy individuals. Following periodontal treatment, serum IL‐1β levels decreased at Days 30 ( <jats:italic>p</jats:italic> = 0.036) and 90 ( <jats:italic>p</jats:italic> = 0.025) while GCF IL‐1β levels showed a reduction at Day 14 ( <jats:italic>p</jats:italic> = 0.001). Periostin levels in GCF in patients with periodontitis were lower than in healthy individuals at baseline ( <jats:italic>p</jats:italic> = 0.001). It increased after treatment, reaching peak values on Day 14 ( <jats:italic>p</jats:italic> = 0.001), followed by a gradual decrease on Days 30 ( <jats:italic>p</jats:italic> = 0.007) and 90 ( <jats:italic>p</jats:italic> = 0.001). Levels of FGF‐2 in GCF increased after periodontal treatment compared with baseline in patients with periodontitis, reaching peak levels on Day 2 ( <jats:italic>p</jats:italic> = 0.001). Following periodontal treatment, periostin and FGF‐2 levels remained higher in the periodontitis group than in the healthy group ( <jats:italic>p</jats:italic> &lt; 0.05), whereas IL‐1β levels decreased to levels comparable to those of the healthy group by Day 30 ( <jats:italic>p</jats:italic> ≥ 0.05). Conclusion In parallel with the reduction in periodontal tissue inflammation and IL‐1β, periostin levels in GCF increased in response to periodontal treatment, suggesting its involvement in tissue healing in patients with periodontitis.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"9 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular Vesicles From Young Brain–Mediated Delivery of PRDX3 Ameliorates Alveolar Bone Loss in Periodontitis","authors":"Jiajie Mao,&nbsp;Yuzhu Wu,&nbsp;Yuxian Xia,&nbsp;Jiahui Shen,&nbsp;Xiaoyuan Huang,&nbsp;Shixing Ma,&nbsp;Xiaofeng Yang,&nbsp;Yanhua Lan","doi":"10.1111/jcpe.70158","DOIUrl":"10.1111/jcpe.70158","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To elucidate the influence and mechanism of extracellular vesicles (EVs) derived from brain tissue with ageing regulating alveolar bone resorption in periodontitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>EVs secreted by young brain tissue (YBEVs) were assessed in a periodontitis model. Further, macrophages were treated with YBEVs or lipopolysaccharide in vitro. RNA sequencing and proteomic analysis were performed to explore how YBEVs influenced inflammatory macrophages, and the expression of peroxiredoxin 3 (PRDX3) as well as of NF-κB pathway-related factors was detected by Western blotting. PRDX3 modulators were employed to explore the NF-κB pathway's impact on inflammatory macrophage in vitro and in vivo.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>YBEVs suppressed the inflammatory response in macrophages in vitro and reduced inflammation and bone resorption in vivo. Multi-omics analyses, including cellular transcriptomics, vesicular cargo transcriptomics and single-cell profiling of brain tissue, together with in vitro and in vivo experiments, suggested that YBEVs modulated the immune response and the NF-κB signalling pathway implicating PRDX3 as a key effector.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>By delivering PRDX3 and inhibiting the activation of the NF-κB pathway, YBEVs inhibit inflammatory macrophages and decrease alveolar bone loss. This study provides new insight into the association between the brain and age-related periodontitis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 11","pages":"1722-1734"},"PeriodicalIF":8.3,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148348841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpreting Population Survey Measures of Periodontal Disease Experience Under Severity-Dependent Tooth Loss","authors":"Kym M. McCormick,&nbsp;Najith Amarasena,&nbsp;Gina Guzzo,&nbsp;Sonia Nath,&nbsp;Lisa Jamieson","doi":"10.1111/jcpe.70198","DOIUrl":"10.1111/jcpe.70198","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Clinical attachment loss (CAL) measured at retained teeth is used as an indicator of periodontal disease experience. Because CAL can be measured only on teeth present at examination, retained-dentition summaries are conditioned on the observable dentition. Where tooth loss is severity-dependent, severely affected teeth may be preferentially removed from observation, causing these summaries to diverge from cumulative disease experience across the original dentition. We hypothesised that CAL summaries more sensitive to severe attachment loss would show earlier and stronger attenuation at older ages than broader summaries that are less dependent on extreme values.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Using nationally representative data from adults aged ≥ 30 years in NHANES 2009–2014, we examined age-specific trajectories across mean and threshold-based CAL summaries and assessed whether divergence between summaries followed the pattern predicted under severity-dependent tooth loss.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The proportion of sites measured declined from 93% at ages 30–34 to 68% at ≥ 80 years, establishing the structural basis for divergence across CAL summaries. Attenuation increased across higher CAL thresholds: higher threshold extent measures were most affected, while lower threshold measures showed more stable trajectories.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Cross-sectional CAL summaries reflect disease among surviving teeth rather than cumulative damage across teeth originally at risk. Attenuation at older ages is consistent with depletion of severely affected teeth rather than biological slowing. Distortion varies by the measure, with higher threshold and mean-based indices most affected; CAL ≥ 3 mm threshold provides a more stable basis for age comparisons.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 11","pages":"1681-1690"},"PeriodicalIF":8.3,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70198","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial Network Signatures Associated With Outcomes of Peri‐Implantitis Therapy","authors":"Seung‐Hyun Park, Da‐Mi Kim, Seulbin Im, Eduardo H. de Souza Oliveira, Ignacio Sanz‐Martin, Ignacio Sanz‐Sanchez, Jan Derks, Magda Feres, Jae‐Kook Cha","doi":"10.1111/jcpe.70214","DOIUrl":"https://doi.org/10.1111/jcpe.70214","url":null,"abstract":"Aim To investigate the microbial network signatures associated with outcomes following surgical therapy of peri‐implantitis. Materials and Methods Microbiological data from a 1‐year randomised controlled trial of 28 patients (28 implants) were analysed. Based on a composite outcome (probing depth ≤ 5 mm, minimal bleeding on probing and no further marginal bone loss) at 1 year, implant sites were categorised into a successful ( <jats:italic>n</jats:italic> = 10) or a non‐successful group ( <jats:italic>n</jats:italic> = 18). Peri‐implant crevicular fluid was collected at baseline and at 3, 6 and 12 months and analysed using 16S rRNA gene sequencing. Results A significant compositional shift from baseline to 1 year was observed in the successful group ( <jats:italic>p</jats:italic> = 0.001), with a significant increase in <jats:styled-content style=\"fixed-case\"> <jats:italic>Rothia aeria</jats:italic> </jats:styled-content> ( <jats:italic>p</jats:italic> = 0.048), <jats:styled-content style=\"fixed-case\"> <jats:italic>Haemophilus parainfluenzae</jats:italic> </jats:styled-content> ( <jats:italic>p</jats:italic> = 0.033) and <jats:italic>Neisseria oralis</jats:italic> ( <jats:italic>p</jats:italic> = 0.025) over time. Network analysis revealed that the successful group exhibited a <jats:styled-content style=\"fixed-case\"> <jats:italic>Porphyromonas gingivalis</jats:italic> </jats:styled-content> ‐associated module enriched with high‐centrality commensals at baseline, and significantly greater network edge density ( <jats:italic>p</jats:italic> = 0.005) and connectivity ( <jats:italic>p</jats:italic> = 0.018) at 1 year. Spearman correlation analyses at 1 year identified significant negative correlations between <jats:styled-content style=\"fixed-case\"> <jats:italic>P. gingivalis</jats:italic> </jats:styled-content> and commensals including <jats:styled-content style=\"fixed-case\"> <jats:italic>H. parainfluenzae</jats:italic> </jats:styled-content> , <jats:italic>Streptococcus</jats:italic> species and <jats:italic>Veillonella</jats:italic> undefined ( <jats:italic>p</jats:italic> &lt; 0.05). Conclusion In this exploratory secondary analysis of a small cohort, favourable outcomes of peri‐implantitis therapy were associated with increased microbial network connectivity and commensal centrality. Trial Registration Korean Clinical Research Information Service number KCT0007900","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"167 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Periodontal Inflammation and Serum Inflammatory Markers in Community‐Dwelling Older Adults in Japan: The Otassha Study”","authors":"","doi":"10.1111/jcpe.70204","DOIUrl":"https://doi.org/10.1111/jcpe.70204","url":null,"abstract":"","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"31 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149130372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Non‐Dental Biofilm‐Induced Gingival Diseases and Conditions: A Systematic Review—Part I: Genetic/Developmental Disorders; Specific Infections; Reactive Processes; Endocrine, Nutritional and Metabolic Diseases; and Traumatic Lesions","authors":"Ana Molina, Inbar Eshkol‐Yogev, Sven Meyle, Asaf Wilensky, Lior Shapira, Joerg Meyle","doi":"10.1111/jcpe.70188","DOIUrl":"https://doi.org/10.1111/jcpe.70188","url":null,"abstract":"Aims To systematically evaluate the effectiveness of preventive and therapeutic interventions for the management of the following non‐dental biofilm‐induced gingival diseases and conditions: genetic/developmental disorders; specific infections; reactive processes; endocrine, nutritional and metabolic diseases; and traumatic lesions. Methods Five systematic searches, one per topic of interest, were performed in four electronic databases, to identify clinical studies reporting on the effectiveness of any intervention aimed at the management of non‐dental biofilm‐induced gingival diseases and conditions in human subjects of all ages. Results One hundred and fifty‐nine papers dealing with the management (prevention and/or treatment) of 32 different conditions affecting the gingiva were included. The level of evidence was low (7 randomized clinical trials, 1 cross‐sectional, 3 cohort studies, 32 case series, 116 case reports). Interventions aiming at prevention were scarce. Treatment of non‐dental biofilm‐induced gingival diseases and conditions studied included: targeted systemic therapy, risk factor control, oral hygiene instructions, professional mechanical plaque removal, scaling and root planing, coadjuvant antiseptics and antibiotics, surgical excision of certain lesions and periodontal plastic surgery. Conclusions The management of non‐dental biofilm‐induced gingival diseases and conditions requires accurate diagnosis, integrated periodontal care, appropriate systemic therapy and regular follow‐up for effective management and prevention of recurrence.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"13 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149087018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The External Validation Trial on the Diagnostic Accuracy of Self‐Reported Measures of Periodontal Disease","authors":"Ke Deng, Steve Lut Ting Lam, Julie Choi Ka Kung, Lijian Jin, Maurizio Tonetti, George Pelekos","doi":"10.1111/jcpe.70208","DOIUrl":"https://doi.org/10.1111/jcpe.70208","url":null,"abstract":"Aim To externally validate a previously developed time‐ and cost‐effective screening tool for screening subjects with different periodontal conditions by combining various questionnaires, demographic data and lifestyle factors, providing a reliable basis for future efforts to promote public awareness of oral/periodontal health and early periodontal care. Methods The study consisted of a self‐administered questionnaire and a full‐mouth periodontal and radiographic examination. External validation was conducted using a representative cohort systematically and randomly selected from the general population of Hong Kong. A modified questionnaire originally proposed by the Centers for Disease Control and Prevention/American Academy of Periodontology (CDC/AAP) was given to participants, and the results were tested against the periodontal case definition based on the 2017 World Workshop Classification of Periodontal Diseases. Accuracy was analysed by multivariate logistic regression, and the area under the receiver operating characteristic curve (AUROC) was calculated. Results A total of 384 subjects participated in this validation study, including individuals with periodontal health (6.2%), gingivitis (19.3%), Stage I/II periodontitis (19.3%) and Stage III/IV periodontitis (55.2%). The screening model, which integrated the CDC/AAP questionnaire with demographic and lifestyle factors, showed the best performance in detecting both periodontitis and severe periodontitis. For periodontitis detection, the model achieved an AUROC of 0.888, with a sensitivity of 91.1% and specificity of 90.0%. For Stage III/IV periodontitis, it showed an AUROC of 0.899, with a sensitivity of 88.8% and specificity of 77.2%. Conclusion This externally validated model demonstrates acceptable accuracy in identifying periodontitis patients in independent populations, supporting its potential applicability across diverse community settings.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"14 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149087017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}