Journal of Clinical Periodontology最新文献_第2页

Association Between Serum Levels of Perfluoroalkyl and Polyfluoroalkyl Substances and Dental Floss Use: The Double-Edged Sword of Dental Floss Use-A Cross-Sectional Study. 血清全氟烷基和多氟烷基物质水平与牙线使用的关系：牙线使用的双刃剑-一项横断面研究

IF 5.8 1区医学

Journal of Clinical Periodontology Pub Date : 2025-01-11 DOI: 10.1111/jcpe.14126

Yan Jiao, Zhuo Fu, Xiaofei Ni

{"title":"Association Between Serum Levels of Perfluoroalkyl and Polyfluoroalkyl Substances and Dental Floss Use: The Double-Edged Sword of Dental Floss Use-A Cross-Sectional Study.","authors":"Yan Jiao, Zhuo Fu, Xiaofei Ni","doi":"10.1111/jcpe.14126","DOIUrl":"https://doi.org/10.1111/jcpe.14126","url":null,"abstract":"Background: Although evidence suggests that dental floss contains perfluoroalkyl and polyfluoroalkyl substances (PFASs), it is still uncertain whether the use of dental floss contributes to an increased risk of PFAS exposure.Methods: We analysed data on serum PFAS concentrations and dental floss usage in a cohort of 6750 adults who participated in the National Health and Nutrition Examination Survey (NHANES) from 2009 to 2020. In our study, we used logistic regression, a survey-weighted linear model, item response theory (IRT) scores, inverse probability weights (IPWs) and sensitivity analysis to assess the potential impact of dental floss usage on human serum PFAS levels.Results: The analysis of six PFASs revealed that dental floss users had higher serum concentrations of perfluorooctanoic acid (PFOA) compared with non-users, while serum concentrations of other PFASs were lower. Dental floss users recorded a lower level of overall PFAS burden score compared with non-users. Sensitivity analysis showed a statistically significant increase in serum PFOA concentration among dental floss users.Conclusion: Our findings suggest that the use of dental floss may be associated differently with serum concentrations of specific PFASs. Among a large representative sample of U.S. adults, individuals reporting the use of dental floss had lower levels of serum PFASs overall, with the exception of PFOA, which was slightly elevated. Dental floss is an important oral hygiene tool, and further research is needed to clarify its role in PFAS exposure.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Periodontitis Increases Gingival, Serum and Hippocampus β‐Amyloid Expressions but Reduces Neurovascular Coupling in Basilar Artery of Rats 牙周炎增加大鼠牙龈、血清和海马β -淀粉样蛋白表达，但减少基底动脉神经血管偶联

IF 6.7 1区医学

Journal of Clinical Periodontology Pub Date : 2025-01-09 DOI: 10.1111/jcpe.14110

Earl Fu, Kuo‐Feng Huang, Hsi‐Hsien Chang, Hui‐Hwa Tseng, Stephen Shei‐Dei Yang

{"title":"Periodontitis Increases Gingival, Serum and Hippocampus β‐Amyloid Expressions but Reduces Neurovascular Coupling in Basilar Artery of Rats","authors":"Earl Fu, Kuo‐Feng Huang, Hsi‐Hsien Chang, Hui‐Hwa Tseng, Stephen Shei‐Dei Yang","doi":"10.1111/jcpe.14110","DOIUrl":"https://doi.org/10.1111/jcpe.14110","url":null,"abstract":"AimNeurodegenerative diseases are characterized by early increased beta‐amyloid (Aβ) and decreased cerebrovascular reactivity. We investigated Aβ in gingiva, serum or hippocampus and neurovascular reactivity in basilar artery (BA) of periodontitis rats, to test the impact of Aβ on BA vasoreactivity ex vivo.Materials and MethodsPeriodontitis was induced in 32 rats using silk‐ligation. Rats were sacrificed at weeks 0, 1, 2 and 4. Gingival TNF‐α, IL‐1β and Aβ were quantified via immunoblotting. Alveolar bone destruction was examined by micro‐computed tomography. Serum and hippocampus Aβ values were measured by enzyme‐linked immunosorbent assay and fluorescence staining, respectively. Vasoreactivity was measured by myography on isolated BA.ResultsFrom Week 1, gingival TNF‐α and IL‐1β and bone destruction increased. Gingiva, serum and hippocampus Aβ values increased from Week 2. Nicotine‐induced BA relaxation declined from Week 2, while acetylcholine‐induced relaxation decreased by Week 4. Bone loss correlated with Aβ and nicotine‐induced relaxation. Correlations were observed between Aβs in tissues, between two induced BA relaxations and between Aβ expressions and the induced relaxations. Ex vivo, Aβ reduced nicotine‐ and isoproterenol‐induced relaxations but not electrical stimulated relaxation.ConclusionsPeriodontitis may increase Aβ expressions and reduce BA neurovascular reactivity, with Aβ contributing to this abnormal neurovascular coupling.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"84 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142939914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence of Gingival Recessions in Adolescent Orthodontic Patients Treated With Fixed Appliances and Lingual Retainer 青少年正畸患者使用固定矫治器和舌固位器治疗牙龈衰退的发生率

IF 6.7 1区医学

Journal of Clinical Periodontology Pub Date : 2025-01-09 DOI: 10.1111/jcpe.14097

Beatriz Celis, Javier Sanz‐Esporrin, Carina Verdasco, Rosa‐Maria Yañez‐Vico, Conchita Martin

{"title":"Incidence of Gingival Recessions in Adolescent Orthodontic Patients Treated With Fixed Appliances and Lingual Retainer","authors":"Beatriz Celis, Javier Sanz‐Esporrin, Carina Verdasco, Rosa‐Maria Yañez‐Vico, Conchita Martin","doi":"10.1111/jcpe.14097","DOIUrl":"https://doi.org/10.1111/jcpe.14097","url":null,"abstract":"AimTo evaluate risk indicators for gingival recessions (GRs) in the lower anterior teeth of orthodontic patients post treatment and during a retention period of at least 5 years, compared to non‐treated controls.Material and MethodsEighty‐nine orthodontically treated patients who were recession‐free before treatment were recruited. Demographic, cephalometric and occlusal records were retrieved before (T1) and after treatment (T2), and periodontal outcomes were clinically evaluated at least 5 years post retention (T3). Eighty‐eight non‐treated patients served as controls. Recession areas were digitally assessed and compared using t‐test and chi‐square tests, and a multiple linear regression model was built.ResultsIn the treated group, recession incidence was 11.24% at T2 and 67.42% at T3, all classified as type 1, class A (−). Among controls, recession prevalence was 15.91%, similar to the incidence at T2, but significantly lower than at T3. GR was most common in canines (1.85 mm2; 95% CI: 2.61–7.70; p < 0.005). Regression analysis identified higher incidence of recessions in female patients and in those with thin phenotype, high angle skeletal pattern, increased final inclination of lower incisors and greater probing depth.ConclusionsGR incidence after orthodontic treatment was comparable to controls but increased significantly post retention. Several risk indicators may predict GR occurrence.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"92 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142939912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations Between Socioeconomic, Spatial and Educational Factors and Midlife Periodontal Disease Risk: Evidence From ‘High School and Beyond’ 社会经济、空间和教育因素与中年牙周病风险之间的关系：来自“高中及以上”的证据

IF 6.7 1区医学

Journal of Clinical Periodontology Pub Date : 2025-01-08 DOI: 10.1111/jcpe.14113

John Robert Warren, Jessie Himmelstern, Chandra Muller, Eric Grodsky, Ryan Demmer

{"title":"Associations Between Socioeconomic, Spatial and Educational Factors and Midlife Periodontal Disease Risk: Evidence From ‘High School and Beyond’","authors":"John Robert Warren, Jessie Himmelstern, Chandra Muller, Eric Grodsky, Ryan Demmer","doi":"10.1111/jcpe.14113","DOIUrl":"https://doi.org/10.1111/jcpe.14113","url":null,"abstract":"BackgroundPeriodontal disease (PD) is a prevalent, preventable and treatable oral infection associated with substantial morbidity globally. There is little information from population‐representative cohort studies about the sociodemographic, educational and other early life factors that stratify PD risk.MethodsWe used data from the U.S. ‘High School and Beyond’ (HS&B:80) study, which has followed a nationally representative sample of 26,820 people from high school in 1980 through midlife in 2021. Data from the 1980s include information about education, early life circumstances, spatial location and demographic attributes. Data from 13,080 sample members who responded in 2021 include indicators of self‐reported PD diagnosis.ResultsPeople with higher degrees and course grades have a lower risk of midlife PD. Rural adolescents and those who attended private schools are also at lower risk. We find little evidence of heterogeneity in correlates of midlife PD by gender or race/ethnicity.ConclusionsThe quantity and characteristics of people's schooling and their location of residence are associated with midlife PD.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"28 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142936327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “Host‐Derived Diagnostic Markers Related to Soft Tissue Destruction and Bone Degradation in Periodontitis” 更正“牙周炎中与软组织破坏和骨降解相关的宿主来源诊断标记”

IF 6.7 1区医学

Journal of Clinical Periodontology Pub Date : 2025-01-08 DOI: 10.1111/jcpe.14114

引用次数: 0

IF 6.7 1区医学

Journal of Clinical Periodontology Pub Date : 2025-01-07 DOI: 10.1111/jcpe.14111

Yiming Jiang, Zihan Wang, Kaige Zhang, Yue Hu, Dehao Shang, Lulu Jiang, Minghao Huang, Biyao Wang, Xiaomin He, Zhou Wu, Xu Yan, Xinwen Zhang

{"title":"Dynamin‐Related Protein 1 Orchestrates Inflammatory Responses in Periodontal Macrophages via Interaction With Hexokinase 1","authors":"Yiming Jiang, Zihan Wang, Kaige Zhang, Yue Hu, Dehao Shang, Lulu Jiang, Minghao Huang, Biyao Wang, Xiaomin He, Zhou Wu, Xu Yan, Xinwen Zhang","doi":"10.1111/jcpe.14111","DOIUrl":"https://doi.org/10.1111/jcpe.14111","url":null,"abstract":"AimTo explore the potential roles of mitochondrial dysfunction in the initiation of inflammation in periodontal macrophages and to determine the mechanism underlying the involvement of dynamin‐related protein 1 (Drp1) in macrophage inflammatory responses through its interaction with hexokinase 1 (HK1).Materials and MethodsGingival tissues were collected from patients diagnosed with periodontitis or from healthy volunteers. Drp1 tetramer formation and phosphorylation were analysed using western blot. THP‐1 macrophages and RAW264.7 cells were stimulated with Porphyromonas gingivalis (Pg) or Pg lipopolysaccharide (Pg LPS), respectively. Alterations in proteins associated with mitochondrial dynamics were scrutinized via western blot. Immunofluorescence was used to evaluate mitochondrial damage and mitochondrial permeability transition pore (mPTP) opening. Western blot was used to examine the inflammatory markers NLRP3, caspase‐1, IL‐1β and GSDMD. Protein interactions involving Drp1 were verified through immunoprecipitation.ResultsIn periodontitis patient samples, Pg LPS‐treated RAW264.7 cells, and Pg‐stimulated THP‐1 macrophages, over‐activated Drp1 was able to drive NLRP3 inflammasome activation and the subsequent release of inflammatory factors. A direct interaction between Drp1 and HK1 was observed, facilitating excessive mPTP opening and subsequent mitochondrial dysfunction.ConclusionIn the inflammatory milieu of periodontal tissues, Drp1 hyperactivation in the macrophages is implicated in inflammation induction. Modulation of the inflammatory response in periodontal macrophages by Drp1 appears to facilitate mPTP opening.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"5 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142935144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Periodontal Care Is Associated With a Lower Risk of Dialysis Initiation in Middle‐Aged Patients With Type 2 Diabetes Mellitus: A 6‐Year Follow‐Up Cohort Study Based on a Nationwide Healthcare Database 牙周护理与中年2型糖尿病患者较低的透析起始风险相关：一项基于全国卫生保健数据库的6年随访队列研究

IF 6.7 1区医学

Journal of Clinical Periodontology Pub Date : 2025-01-06 DOI: 10.1111/jcpe.14105

Taro Kusama, Yudai Tamada, Ken Osaka, Kenji Takeuch

{"title":"Periodontal Care Is Associated With a Lower Risk of Dialysis Initiation in Middle‐Aged Patients With Type 2 Diabetes Mellitus: A 6‐Year Follow‐Up Cohort Study Based on a Nationwide Healthcare Database","authors":"Taro Kusama, Yudai Tamada, Ken Osaka, Kenji Takeuch","doi":"10.1111/jcpe.14105","DOIUrl":"https://doi.org/10.1111/jcpe.14105","url":null,"abstract":"ObjectiveTo investigate the association between dental attendance with periodontal care and the risk of dialysis initiation in patients with type 2 diabetes mellitus (T2D).MethodsThis retrospective cohort study used data from the Japan Medical Data Center (JMDC) claims database (January 2015 to August 2022). Patients with T2D, aged 40–74, were included. Dental attendance with periodontal care and initiation of dialysis were used as the exposure and outcome variables, respectively. We fitted the Cox proportional hazards model, including potential confounders, to estimate hazard ratios (HRs) and 95% confidence intervals (95%CIs).ResultsAmong 99,273 participants (mean age = 54.4 years [SD = 7.8], male = 71.9%), the incidence rate of dialysis initiation was 0.92 per 1000 person‐years. After adjusting for all covariates, those with periodontal care (HR = 0.68 [95%CI = 0.51–0.91] for ≥ 1 time/year and HR = 0.56 [95%CI = 0.41–0.77] for ≥ 1 time/6 months) had a significantly lower risk of dialysis initiation compared to those without dental attendance.ConclusionPeriodontal disease care in patients with T2D is associated with a reduced risk of dialysis initiation by 32%–44%. This suggests that integrating periodontal care into diabetes management may help prevent the progression of diabetic nephropathy and improve patient outcomes.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"203 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Retrospective Study of Stabilizing Bridges in Patients With Stages III and IV Periodontitis: Up to 35 Years of Clinical Audit. 在III期和IV期牙周炎患者中稳定牙桥的回顾性研究：长达35年的临床审计。

IF 5.8 1区医学

Journal of Clinical Periodontology Pub Date : 2025-01-05 DOI: 10.1111/jcpe.14116

Øystein Fardal, Jostein Grytten

{"title":"A Retrospective Study of Stabilizing Bridges in Patients With Stages III and IV Periodontitis: Up to 35 Years of Clinical Audit.","authors":"Øystein Fardal, Jostein Grytten","doi":"10.1111/jcpe.14116","DOIUrl":"https://doi.org/10.1111/jcpe.14116","url":null,"abstract":"Background/aim: Studies on large cross-arch bridges in patients with severe periodontitis show that such bridges can stabilize the periodontal condition. However, it is not known if these bridges will reduce long-term tooth loss and what factors are important for their long-term survival. The aim of the study was to study all patients with Stages III/IV periodontitis who received cross-arch bridges for up 35 years in a private practice.Materials and methods: All patients referred for periodontal treatment from 1986 who received cross-arch bridges with observation period of minimum 7 years were assessed. All dropouts were accounted for.Results: Ninety-eight patients (1.7% of the patient population) with 111 bridges were observed (57 females and 37 males). Age at bridge construction was 55.4 years (SD = 7.1, range 39-79). Failure rate was 14.4% at 16.1 years (SD = 4.0 range 10-22). Reasons for failure were poor oral hygiene (p = 0.0093) and complications such as caries, endontics, porcelain fractures and gingival retractions during maintenance therapy (p = 0.0059). Fewer abutment teeth were lost from the bridges than teeth from the same and opposing arches (8.8% vs. 34.4% and 25.4%) (p < 0.0001).Conclusion: Cross-arch bridges constructed for patients with Stages III and IV periodontitis were successful in terms of longevity, low failure rates, tooth preservation and patient satisfaction.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Periodontal Probing Depth Trajectory in 10 Years of Follow‐Up as Associated With Tooth Loss 牙周探查深度与牙齿脱落的10年随访

IF 6.7 1区医学

Journal of Clinical Periodontology Pub Date : 2025-01-02 DOI: 10.1111/jcpe.14117

Peter Meisel, Henry Völzke, Thomas Kocher

{"title":"Periodontal Probing Depth Trajectory in 10 Years of Follow‐Up as Associated With Tooth Loss","authors":"Peter Meisel, Henry Völzke, Thomas Kocher","doi":"10.1111/jcpe.14117","DOIUrl":"https://doi.org/10.1111/jcpe.14117","url":null,"abstract":"AimTo elucidate whether ranked probing depth (PD) data translate into ranked PD outcomes after 10 years of follow‐up and the associated tooth loss.Materials and MethodsFrom the Study of Health in Pomerania (SHIP‐START), all participants were retrospectively included with complete PD measurements in both baseline and 10‐year follow‐up, comprising 1887 participants. The trajectory of percentile‐based quintiles of mean PD measurements was followed.ResultsQuintiles of mean PD at baseline were, in a dose dependent manner, associated with the number of teeth at baseline, number of teeth after 10 years and involved risk of tooth loss. The trajectory of membership to individual PD quintiles indicated that the majority of participants remained in or near their baseline quintile after reaching the 10‐year end analysis. Periodontal risk factors assessed at baseline continued to affect PD outcomes at follow‐up. Two categories of tooth loss were identified: 1–2 teeth lost versus ≥ 3 teeth and differentiated by baseline PD.ConclusionPD severity ranked within this population translates, in a dose‐dependent manner, to follow‐up tooth loss even after many years. This underlines the prospective importance of pocket probing in the dental practice. Ranked PD offers a simple measure to identify patients at high risk of tooth loss.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"72 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Persisting Chronic Periodontal Disease as a Risk Factor for Cardiovascular Disease: A Nationwide Population‐Based Cohort Study 持续性慢性牙周病是心血管疾病的危险因素：一项基于全国人群的队列研究

IF 6.7 1区医学

Journal of Clinical Periodontology Pub Date : 2024-12-27 DOI: 10.1111/jcpe.14107

Jung‐Hyun Park, Gwang Hyun Leem, Jin‐Woo Kim, Tae‐Jin Song

{"title":"Persisting Chronic Periodontal Disease as a Risk Factor for Cardiovascular Disease: A Nationwide Population‐Based Cohort Study","authors":"Jung‐Hyun Park, Gwang Hyun Leem, Jin‐Woo Kim, Tae‐Jin Song","doi":"10.1111/jcpe.14107","DOIUrl":"https://doi.org/10.1111/jcpe.14107","url":null,"abstract":"AimsEpidemiological studies have consistently established a positive association between periodontal disease (PD) and cardiovascular disease (CVD). However, large‐scale investigations exploring the impact of changes in PD status on CVD risk are scarce. This study aimed to investigate the association between the dynamics in PD and the risk of incident CVD in a nationally representative population.MethodsUtilising data from the Korean National Health Insurance Service, a cohort of 1,242,570 participants who underwent oral health exams in 2003 and a follow‐up exam in 2005–2006 was analysed. Participants were categorized into groups based on changes in PD status: absent, improvement, onset and persistent. Cox proportional hazard models were employed to assess the multivariate‐adjusted hazard ratios (HRs) for composite CVD outcomes, including death, myocardial infarction and stroke.ResultsOver a mean follow‐up of 14.4 years, 79,810 (6.4%) cases of composite CVD occurred, including 14,296 (1.2%) myocardial infarctions, 3247 (0.3%) hemorrhagic strokes and 8900 (0.7%) ischemic strokes. Individuals with persistent PD showed the highest risk of CVD (HR: 1.04, 95% CI: 1.03–1.06, p < 0.001). In the pairwise comparisons, the PD improvement group exhibited a lower composite CVD risk than the PD persistent group (HR: 0.97, 95% CI: 0.96–0.99, p = 0.010); similarly, the PD onset group showed a lower risk than the PD persistent group (HR: 0.94, 95% CI: 0.93–0.96, p < 0.001). This pattern was consistent in the risk of death, with both the PD improvement and PD onset groups showing a lower risk of death than the PD persistent group.ConclusionThis study suggests the dynamic nature of PD as a potential modifiable risk factor for CVD. Individuals with chronically persistent PD showed an elevated incidence risk of CVD, emphasizing the importance of managing PD in preventive strategies.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"25 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142887906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0