Journal of Clinical Periodontology最新文献

{"title":"Cathepsin B Modulates Alzheimer's Disease Pathology Through SAPK/JNK Signals Following Administration of Porphyromonas gingivalis‐Derived Outer Membrane Vesicles","authors":"Muzhou Jiang, Ziming Ge, Shoucheng Yin, Yanqing Liu, Hanyu Gao, Lijie Lu, Hongyan Wang, Chen Li, Junjun Ni, Yaping Pan, Li Lin","doi":"10.1111/jcpe.14109","DOIUrl":"https://doi.org/10.1111/jcpe.14109","url":null,"abstract":"Aim<jats:styled-content style=\"fixed-case\"><jats:italic>Porphyromonas gingivalis</jats:italic></jats:styled-content>, a consensus periodontal pathogen, is thought to be involved in Alzheimer's disease (AD) progression, and <jats:styled-content style=\"fixed-case\"><jats:italic>P. gingivalis</jats:italic></jats:styled-content>‐derived outer membrane vesicles (<jats:italic>Pg</jats:italic>OMVs) are a key toxic factor in inducing AD pathology. This study aimed to clarify the regulatory mechanism underlying the <jats:italic>Pg</jats:italic>OMV‐induced AD‐like phenotype.Materials and MethodsWe intraperitoneally injected <jats:italic>Pg</jats:italic>OMVs into the periphery of wild‐type and <jats:italic>CatB</jats:italic> knockout mice for 4 or 8 weeks to assess the effect of CatB on <jats:italic>Pg</jats:italic>OMV‐induced AD pathology. Mice were evaluated for cognitive change, tau phosphorylation, microglial activation, neuroinflammation and synapse loss. Microglial and primary neuron culture were prepared to verify the in vivo results.ResultsCatB deficiency significantly alleviated <jats:italic>Pg</jats:italic>OMV‐induced cognitive dysfunction, microglia‐mediated neuroinflammation, tau hyperphosphorylation and synapse loss. Subsequent transcriptomic analysis, immunofluorescence and immunoblotting suggested that CatB modulates microglia‐mediated neuroinflammation through stress‐activated protein kinases (SAPK)/Jun amino‐terminal kinases (JNK) signals after administration of <jats:italic>Pg</jats:italic>OMVs, which in turn regulates neuronal tau phosphorylation and synapse loss in a SAPK/JNK‐dependent manner.ConclusionOur study unveils a previously unknown role of CatB in regulating <jats:italic>Pg</jats:italic>OMV‐induced AD pathology.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"12 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142887902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Accuracy of Novel Protein Biomarkers in Saliva to Detect Periodontitis Using Untargeted ‘SWATH’ Mass Spectrometry","authors":"T. Blanco-Pintos,&nbsp;A. Regueira-Iglesias,&nbsp;M. Relvas,&nbsp;M. Alonso-Sampedro,&nbsp;S. B. Bravo,&nbsp;C. Balsa-Castro,&nbsp;I. Tomás","doi":"10.1111/jcpe.14103","DOIUrl":"10.1111/jcpe.14103","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To discover new salivary biomarkers to diagnose periodontitis and evaluate the impact of age and smoking on predictive capacity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Saliva samples were collected from 44 healthy periodontal individuals and 41 with periodontitis. Samples were analysed by sequential window acquisition of all theoretical mass spectra (SWATH-MS), and proteins were identified by employing the UniProt database. The diagnostic capacity of the molecules was determined with generalized additive models. The models obtained were single-protein unadjusted and adjusted for age and smoking status, besides two-protein combinations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Eight single salivary proteins had a bias-corrected accuracy (bc-ACC) of 78.8%–86.8% (bc-sensitivity/bc-specificity of 62.5%–86.9%/60.9%–98.1%) to diagnose periodontitis. Predictive capacity increased more by adjusting for age (bc-ACC: 94.1%–98.2%; bc-sensitivity/bc-specificity: 90.2%–98.6%/93.6%–97.2%) than smoking (bc-ACC: 83.9%–90.4%; bc-sensitivity/bc-specificity: 73.6%–89.9%/76.2%–96.4%). These proteins were keratin, type II cytoskeletal 1, protein S100-A8, β-2-microglobulin, neutrophil defensin 1, lysozyme C, ubiquitin-60S ribosomal protein L40, isoform 2 of tropomyosin α-3 chain and resistin. Two dual combinations showed bc-sensitivity/bc-specificity of &gt; 90%: β-2-microglobulin with profilin-1, and lysozyme C with zymogen granule protein 16 homologue B.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>New salivary biomarkers show good or excellent ability to diagnose periodontitis. Age has a more significant influence on the accuracy of the single biomarkers than smoking, with results comparable to two-protein combinations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 2","pages":"199-214"},"PeriodicalIF":5.8,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14103","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142887870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Comparative Evaluation of a Reinstructed GPT‐4o Model Specialized in Periodontology","authors":"Francesco Fanelli, Muhammad Saleh, Pasquale Santamaria, Khrystyna Zhurakivska, Luigi Nibali, Giuseppe Troiano","doi":"10.1111/jcpe.14101","DOIUrl":"https://doi.org/10.1111/jcpe.14101","url":null,"abstract":"BackgroundArtificial intelligence (AI) has the potential to enhance healthcare practices, including periodontology, by improving diagnostics, treatment planning and patient care. This study introduces ‘PerioGPT’, a specialized AI model designed to provide up‐to‐date periodontal knowledge using GPT‐4o and a novel retrieval‐augmented generation (RAG) system.MethodsPerioGPT was evaluated in two phases. First, its performance was compared against those of five other chatbots using 50 periodontal questions from specialists, followed by a validation with 71 questions from the 2023–2024 ‘In‐Service Examination’ of the American Academy of Periodontology (AAP). The second phase focused on assessing PerioGPT's generative capacity, specifically its ability to create complex and accurate periodontal questions.ResultsPerioGPT outperformed other chatbots, achieving a higher accuracy rate (81.16%) and generating more complex and precise questions with a mean complexity score of 3.81 ± 0.965 and an accuracy score of 4.35 ± 0.898. These results demonstrate PerioGPT's potential as a leading tool for creating reliable clinical queries in periodontology.ConclusionsThis study underscores the transformative potential of AI in periodontology, illustrating that specialized models can offer significant advantages over general language models for both educational and clinical applications. The findings highlight that tailoring AI technologies to specific medical fields may improve performance and relevance.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"14 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142887908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone Regeneration After Sinus Floor Elevation in an Intact Sinus or a Sinus With Prior Large Membrane Perforation: A Preclinical Study Using a Rabbit Sinus Model","authors":"Sunmin Lee, Jong‐Hyuk Chung, Daniel S. Thoma, Ronald E. Jung, Ui‐Won Jung, Seung‐Yun Shin, Hyun‐Chang Lim","doi":"10.1111/jcpe.14108","DOIUrl":"https://doi.org/10.1111/jcpe.14108","url":null,"abstract":"AimTo determine bone regeneration following sinus floor elevation (SFE) at sites with or without prior sinus membrane perforation.Materials and MethodsThe sinus membranes in the maxillary sinuses of 12 rabbits were intentionally perforated (≥ 5 mm) on one side, followed by application of a collagen matrix. SFE was performed on both sinuses after 8 weeks of healing, presenting two groups: SFE with a previous large sinus membrane perforation (group SFE_Perf), and in an intact sinus (group SFE). The animals were euthanized at 2 and 4 weeks after SFE. Micro‐computed tomographic and histomorphometric analyses were performed.ResultsThe amount of newly formed bone within the augmented area did not differ significantly between the two groups at 2 weeks and 4 weeks (4.7 ± 1.0 mm<jats:sup>2</jats:sup> vs. 5.3 ± 1.4 mm<jats:sup>2</jats:sup> and 9.2 ± 1.7 mm<jats:sup>2</jats:sup> vs. 10.8 ± 2.2 mm<jats:sup>2</jats:sup>, respectively, mean ± SD; <jats:italic>p</jats:italic> &gt; 0.05). However, the amount of newly formed bone near the middle of the sinus membranes was significantly greater in group SFE than in group SFE_Perf (<jats:italic>p</jats:italic> &lt; 0.05). There was no significant difference in the augmented volume. Fewer subepithelial glands and denser collagen fibres within the sinus membranes were observed in group SFE_Perf than in group SFE.ConclusionsA large perforation of the sinus membrane followed by an 8‐week healing period did not jeopardize new bone formation following SFE.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"70 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Effect of Smoking and Cessation on Tooth Loss","authors":"Sebastian‐Edgar Baumeister, Stefan Listl, Birte Holtfreter, Gustavo G. Nascimento, Fabio R. M. Leite","doi":"10.1111/jcpe.14106","DOIUrl":"https://doi.org/10.1111/jcpe.14106","url":null,"abstract":"AimTo estimate the causal effects of smoking and cessation on tooth loss using instrumental variable (IV) analysis.Material and MethodsData from the Behavioural Risk Factor Surveillance System (BRFSS), conducted from 1995 to 2006, 2008, 2010, and 2012 in 50 U.S. states and Washington DC, were merged with cigarette pack prices and smoking ban data from the CDC ‘Tax Burden on Tobacco’ and ‘State Tobacco Activities Tracking and Evaluation’ (STATE) System. Prices and bans served as IVs for ever smoking and cessation in a control function IV model for self‐reported edentulism and loss of 6+ teeth. IV models were adjusted for age, sex, race/ethnicity, educational attainment, type 2 diabetes, state unemployment rates, state health expenditures, and state fixed effects.ResultsEver smoking cigarettes increased the risk of edentulism by 2.6% (95% CI: 2.3%–2.8%) and the risk of loss of 6+ teeth by 10.7% (95% CI: 10.0%–11.3%). Smoking cessation reduced risks of edentulism and loss of 6+ teeth by 7.6% (95% CI: −7.8% to −742%) and 13.5% (95% CI: −13.7% to 13.3%), respectively.ConclusionThis study provides robust evidence that smoking increases tooth loss risk, while cessation significantly reduces it, emphasizing the oral health benefits of tobacco control policies.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"24 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Single-Cell Genomics to Animal Models of Periodontitis and Peri-Implantitis","authors":"Akira Hasuike,&nbsp;Quinn T. Easter,&nbsp;Daniel Clark,&nbsp;Kevin M. Byrd","doi":"10.1111/jcpe.14093","DOIUrl":"10.1111/jcpe.14093","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This narrative review aims to synthesize current knowledge on integrating single-cell genomics technologies with animal models of periodontitis and peri-implantitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Review</h3>\u0000 \u0000 <p>Single-cell RNA sequencing (scRNAseq) reveals cellular heterogeneity and specific cell roles in periodontitis and peri-implantitis, overcoming the limitations of bulk RNA sequencing. Under controlled conditions and genetic manipulation, animal models facilitate studying disease progression, gene functions and systemic disease links, aiding targeted therapy development. Knockout models have started to elucidate the impact of genetic mutations on periodontal disease and host responses. scRNAseq in animal models has been used to examine connections between periodontitis and systemic diseases, revealing altered immune environments and cellular interactions. Emerging studies are now applying these methods to animal models of peri-implantitis. Integrating these datasets into single-cell and spatially resolved atlases will enable future meta-analyses, providing deeper insights into disease mechanisms considering factors such as sex, strain, and age.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Integrating scRNAseq with animal models advances the understanding of periodontitis and peri-implantitis pathogenesis and precision therapies. The combined use of single-cell and spatial genomics and scRNAseq will further enhance data insights significantly for drug discovery and preclinical testing, making these technologies pivotal in validating animal models and translating findings into clinical practice.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 2","pages":"268-279"},"PeriodicalIF":5.8,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Note from the Editor","authors":"Panos N. Papapanou","doi":"10.1111/jcpe.14099","DOIUrl":"10.1111/jcpe.14099","url":null,"abstract":"","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"51 12","pages":"1546"},"PeriodicalIF":5.8,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142841075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Survey Among General Practitioners and Periodontal Specialists in Norway Documenting a Positive Attitude Towards Guideline-Based Referral Practise.","authors":"Eirik M Aaen, Dagmar F Bunæs, Stein A Lie, Kristian H Lind, Knut N Leknes","doi":"10.1111/jcpe.14096","DOIUrl":"https://doi.org/10.1111/jcpe.14096","url":null,"abstract":"<p><strong>Aim: </strong>The objective of this cross-sectional survey was to assess the attitude among general practitioners (GPs) and periodontal specialists (PSs) in Norway towards developing and implementing guideline-based periodontal referral practise.</p><p><strong>Material and methods: </strong>A multiple-choice questionnaire was distributed online to a sample of professionally active GPs and PSs. The survey included questions on demographics, practise profile, proficiency and insight among oral healthcare providers, periodontal referral patterns, and attitude on establishing guideline-based referral practise. Logistic regression analyses were employed to estimate associations between dependent and selected independent variables. Inverse probability weights (IPW) were applied to adjust for non-response in the logistic regression models.</p><p><strong>Results: </strong>Analyses were based on answers from 353 GPs and 49 PSs. The majority of GPs (77.9%) considered periodontal referral guidelines as a useful tool if they were available, and 59.2% of PSs expressed a positive attitude for implementing guideline-based referral practise to prevent premature or delayed referrals. In total, 93.9% of PSs reported that patients with periodontitis were being referred from GPs too late either frequently or sometimes. Females tended to be more interested in utilising referral guidelines than males (odds ratio, OR = 2.89, p < 0.001). Older GPs and those with increasing years of practising, were less interested in using referral guidelines than younger and more inexperienced GPs (both p < 0.05).</p><p><strong>Conclusions: </strong>The findings document a positive attitude and significant need for developing and implementing periodontal referral guidelines among GPs and PSs, ensuring timely identification and referral of patients with periodontitis.</p>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142836669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Vertical Inter-Implant Distance in Two Adjacent Single-Unit Posterior Implants: A Retrospective Cohort Study With 1-8 Years of Follow-Up.","authors":"Jiayu Gao, Yang Yang, Xingmei Yang, Xuemei Tang, Yili Qu, Yingying Wu, Lin Xiang, Yi Man","doi":"10.1111/jcpe.14094","DOIUrl":"https://doi.org/10.1111/jcpe.14094","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the impact of different vertical interimplant distances (VIDs) on the long-term success of two adjacent single-unit implants.</p><p><strong>Materials and methods: </strong>This retrospective study categorized implants into two groups based on VID: Group 1 (VID < 2 mm) and Group 2 (VID ≥ 2 mm). Further classification was done according to horizontal inter-implant distance (HID). Statistical models were used to evaluate the primary outcome of implant survival, secondary outcomes of complication-free survival rates and radiological findings.</p><p><strong>Results: </strong>We included 290 patients with 376 two adjacent single-unit implants. Group 1 included 223 patients with 280 implants, whereas Group 2 comprised 89 patients with 96 implants. The implant survival rates were 93.2% in Group 1 and 96.8% in Group 2 over the 8 years, with no significant association between the groups. Similarly, the overall complication-free survival rates were 60.6% in Group 1 and 65.6% in Group 2, showing no significant association between the groups. Radiological assessments also showed no notable association between the groups. This trend was consistent in the subgroup analyses based on HID, with no significant differences in implant survival, complication-free survival rates or radiological outcomes.</p><p><strong>Conclusions: </strong>Considering the study limitations of an 8-year post-prosthetic review period and despite varying VIDs, our findings showed no significant difference in implant survival, complication-free survival rates or radiological assessments. This underscores the positive prognosis of two adjacent single-unit implants and contributes to a deeper understanding of the success factors in implantology.</p><p><strong>Trial registration: </strong>The study was registered in the Chinese Clinical Trial Registry (ChiCTR2300073215).</p>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Membrane Stabilization for Alveolar Ridge Preservation in Periodontally Compromised Extraction Sockets: A Non-Inferiority Randomized Controlled Trial.","authors":"Seung-Ju Lee, Jungwon Lee, Hyemee Suh, Young-Chang Ko, Istvan Urban, Ki-Tae Koo","doi":"10.1111/jcpe.14092","DOIUrl":"https://doi.org/10.1111/jcpe.14092","url":null,"abstract":"<p><strong>Aim: </strong>The aim of this study was to investigate the non-inferiority of alveolar ridge preservation (ARP) with membrane stabilization compared with non-stabilization, focusing on changes of soft-tissue contour in periodontally compromised extraction sockets. Secondary outcomes included changes in hard-tissue contour, patient-reported outcomes and new bone formation.</p><p><strong>Materials and methods: </strong>Twenty-four patients with periodontally compromised teeth were randomly assigned to ARP with (test group) or without (control group) membrane stabilization. To assess profilometric and hard-tissue dimensional changes, dental impressions and cone beam computed tomography scans were performed at baseline (T0), immediately after ARP (T1) and 4 months post surgery (T2). Soft-tissue healing in open healing sites was evaluated at T2, and wound closure was assessed 10 days post surgery. Patient-reported outcomes were documented, and core biopsies were obtained for histomorphometric analysis.</p><p><strong>Results: </strong>The absolute profilometric horizontal width change at 3 mm below the crest in the test group was not inferior to that in the control group. For the relative values, horizontal width reduction (3 and 5 mm below the crest) and volumetric shrinkage (3-5 mm below the crest) were lower in the test group. No significant differences were observed in bone dimensional changes, wound healing, pain and swelling or histomorphometric outcomes.</p><p><strong>Conclusion: </strong>ARP with membrane stabilization in periodontally compromised extraction sockets is non-inferior in terms of soft-tissue contour changes to those without membrane fixation.</p><p><strong>Trial registration: </strong>Clinical Research Information Service (CRIS), KCT0005280. Registered 4 August 2020, https://cris.nih.go.kr/cris/search/detailSearch.do?seq=19165&search_page=L.</p>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}