Journal of Clinical Periodontology最新文献

{"title":"Multi-Centre External Validation of a Nomogram for 10-Year Periodontal Tooth Loss Prediction.","authors":"Matteo Serroni, Andrea Ravidà, Pasquale Santamaria, Debora R Dias, Guo-Liang Cheng, Samar Shaikh, Nima David Natanzi, Muhammad H A Saleh, Luigi Nibali, Giuseppe Troiano","doi":"10.1111/jcpe.14143","DOIUrl":"https://doi.org/10.1111/jcpe.14143","url":null,"abstract":"<p><strong>Aims: </strong>To externally validate the potential applicability of the 2018 classification of periodontal diseases as a risk assessment tool, through the use of a nomogram built on a multivariate predictor model.</p><p><strong>Materials and methods: </strong>Data from 459 patients with periodontitis, across four cohorts (three in the United States, and one in the United Kingdom), were retrospectively analysed. After staging and grading periodontitis before active periodontal therapy (APT), patients were categorised by the model as having 'low tooth loss' (≤ 1 teeth lost due periodontal reasons [TLP]) or 'high tooth loss' (≥ 2 TLP) at a 10-year follow-up. Model discrimination was evaluated using the area under the receiver operating characteristic (AUC-ROC) curve. Calibration was assessed through calibration plots, calibration-in-the-large (CITL), calibration slope and the expected:observed (E:O) ratio. Recalibration methods, including Temperature Scaling, Isotonic Regression and Beta Calibration, were also tested.</p><p><strong>Results: </strong>The original nomogram yielded an aggregate AUC-ROC 0.72 but showed poor calibration. Isotonic recalibration improved the AUC-ROC to 0.77 and enhanced calibration metrics, achieving an E-statistic of 1.00, CITL of 0.00 and a calibration slope of 1.00.</p><p><strong>Conclusion: </strong>A nomogram based on the components of the 2018 periodontal disease classification can serve as a prognostic tool with cross-site applicability across clinical settings in industrialised countries, accurately predicting the 10-year risk of tooth loss due to periodontitis from the initial assessment conducted before the start of APT.</p>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intermittent Fasting Regimes Reduce Gingival Inflammation: A Three-Arm Clinical Trial","authors":"C. L. Pappe,&nbsp;J. Maetschker,&nbsp;S. Dujardin,&nbsp;B. Peters,&nbsp;O. Pivovarova-Ramich,&nbsp;F. Kandil,&nbsp;A. Michalsen,&nbsp;C. Breinlinger,&nbsp;N. Steckhan,&nbsp;D. Koppold,&nbsp;H. Dommisch","doi":"10.1111/jcpe.14151","DOIUrl":"10.1111/jcpe.14151","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate the effect of religious Bahá'í dry fasting (BF) or 16:8 time-restricted eating (TRE) compared with a regular diet (CG) on periodontal parameters during a modified experimentally induced gingivitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>All participants were asked to refrain from oral hygiene (3 sextant) for 9 days (T1–T2) and were followed for a total of 19 days (T3) while adhering to fasting or a regular diet and resuming oral hygiene. The primary outcome was bleeding on probing in the test sextant (BOP_s), Rustogi plaque index (RPI), gingival crevicular fluid (GCF), blood pressure (BP), body weight (BW), HbA1c and C-reactive protein (CRP) were measured (T1–T3) and ANCOVA and post hoc comparison were applied.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Sixty-six healthy participants were recruited. Forty-three were randomly assigned to TRE (<i>n</i> = 22) and CG (<i>n</i> = 21), while 23 followed BF, avoiding food and drinks during the day. At T2, BF demonstrated significantly less increase in BOP_s, and GCF increased in CG only. Analysis revealed significant differences in change for BOP_s between BF and CG (−9.48% [−17.18; −1.79]) and BF and TRE (−9.19% [−15.07; −3.32]) as well as for GCF between BF and CG (−0.06 μL [−7.22; −0.66]) and TRE and CG (−0.08 μL [−0.17; −0.00]).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study indicates beneficial effects of different fasting protocols on oral experimental gingivitis and metabolic parameters, but results are limited by randomisation issues and potential bias in the BF group.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 5","pages":"681-694"},"PeriodicalIF":5.8,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14151","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontitis History Shapes the Early Peri-Implant Microbiome Formation: A Metagenomic Analysis.","authors":"Miao Wang, Yi Bing Liu, Wai Man Tong, Wai Keung Leung, Long Long He, Xin Xu, Dan Xu, Qin Zhou","doi":"10.1111/jcpe.14147","DOIUrl":"https://doi.org/10.1111/jcpe.14147","url":null,"abstract":"<p><strong>Aim: </strong>This study aims to investigate the early alterations in microbiome construction and succession around dental implants in both periodontally healthy individuals and patients with a history of periodontitis during the first month after implant-crown placement.</p><p><strong>Materials and methods: </strong>Ninety-five subgingival plaque samples were collected from 10 periodontally compromised patients (PCP) and nine periodontally healthy patients (PHP) at four time points with a 1-week interval and analysed using dynamic metagenomic analysis. The study compared the formation and temporal change in the peri-implant microbiome in the PCP and PHP groups during the first month after the implant crown placement. A two-year follow-up examination was conducted to assess the clinical outcomes of early peri-implant dysbiosis.</p><p><strong>Results: </strong>The results showed that PCP groups exhibited distinctively dysbiotic features in their peri-implant microbiome upon initial establishment, with an earlier and elevated emergence of periodontopathogens. This dysbiosis in the PCP group was associated with significantly higher modified sulcus bleeding index (mBI) scores compared with the PHP group. Neisseria was identified as a key driver of early peri-implant dysbiosis in patients with a periodontitis history.</p><p><strong>Conclusions: </strong>This study established the first microbial link between periodontitis history and early peri-implant dysbiosis, highlighting the importance of early prevention strategies against peri-implant diseases in patients with a periodontitis history.</p>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to Serum lipoprotein subfractions are associated with the periodontal status: Results from the population-based cohort SHIP-TREND","authors":"","doi":"10.1111/jcpe.14130","DOIUrl":"10.1111/jcpe.14130","url":null,"abstract":"<p>Kapp, M., B. Holtfreter, T. Kocher, et al. 2024. “Serum lipoprotein subfractions are associated with the periodontal status: Results from the population-based cohort SHIP-TREND.” <i>Journal of Clinical Periodontology</i> 51, no. 4: 390–405. https://doi.org/10.1111/jcpe.13902.</p><p>The ‘Funding information’ on the title page was incomplete. This should have read ‘German Federal State of Mecklenburg-West Pomerania, Deutsche Forschungsgemeinschaft (project number 451892213)’.</p><p>We apologise for this error.</p>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 5","pages":"800"},"PeriodicalIF":5.8,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14130","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperuricemia Exacerbates Experimental Periodontitis via Uric Acid-Induced Periodontal Inflammation and Oxidative Stress","authors":"Zhicong Wu,&nbsp;Li Zhao,&nbsp;Yi Guo,&nbsp;Chuyin Lin,&nbsp;Peipei Lu,&nbsp;Qian He,&nbsp;Yinghong Zhou,&nbsp;Xinhong Wang,&nbsp;Ting Yu","doi":"10.1111/jcpe.14144","DOIUrl":"10.1111/jcpe.14144","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To investigate the effects of hyperuricemia on periodontitis and the underlying mechanisms by establishing combined animal and cell models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A hyperuricemia mouse model was established by potassium oxonate injection, with sodium carboxymethylcellulose treatment serving as controls. Both models were treated with or without periodontitis induction (<i>n</i> = 10/group). RAW264.7 macrophages and THP-1-derived macrophages were stimulated with \u0000 <i>Porphyromonas gingivalis</i>\u0000 -lipopolysaccharide in the presence of normal or excessive concentrations of uric acid. Allopurinol intervention was applied to both animal and cell models. Periodontal destruction was measured by micro-computed tomography and histology. The immune response and oxidative stress in the periodontium and macrophages were assessed using various methods including immunohistochemistry, quantitative PCR, western blotting, flow cytometry and multiplex cytokine assays.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Potassium oxonate successfully induced hyperuricemia without affecting serum glucose/lipid levels or xanthine oxidoreductase activity. In mice with periodontitis, hyperuricemia exacerbated alveolar bone loss and the presence of osteoclasts and M1 macrophages. Mechanistically, hyperuricemia promoted NLRP3 inflammasome activation, disrupted the inflammatory cytokine response and exacerbated oxidative stress both in the periodontium and in vitro. Allopurinol treatment reversed all relevant changes in both mice and macrophages.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Hyperuricemia exacerbates periodontitis possibly via uric acid-induced periodontal inflammation and oxidative stress.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 5","pages":"773-786"},"PeriodicalIF":5.8,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Ultrasonography, CBCT, Transgingival Probing, Colour-Coded and Periodontal Probe Transparency With Histological Gingival Thickness: A Diagnostic Accuracy Study Revisiting Thick Versus Thin Gingiva","authors":"Hamoun Sabri,&nbsp;Paolo Nava,&nbsp;Parham Hazrati,&nbsp;Abdusalam Alrmali,&nbsp;Pablo Galindo-Fernandez,&nbsp;Muhammad H. A. Saleh,&nbsp;Javier Calatrava,&nbsp;Shayan Barootchi,&nbsp;Lorenzo Tavelli,&nbsp;Hom-Lay Wang","doi":"10.1111/jcpe.14139","DOIUrl":"10.1111/jcpe.14139","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To assess the reliability of ultrasonographic, cone beam computed tomographic (CBCT), probe transparency and transgingival probing (TGP) methods in evaluating gingival thickness (GT), compared with the gold standard histological assessment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Sixteen fresh cadaver heads with intact gingivae were used. The sequence for GT measurement included CBCT, ultrasonography, probe transparency, TGP and histology. Both stainless steel periodontal probe and colour-coded probes were used for transparency. TGP involved a calibrated endodontic spreader, and histologic samples served as a comparative standard. Primary outcomes evaluated accuracy in GT measurement, while secondary outcomes assessed agreement among methods and established an optimal threshold for thin versus thick gingiva.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>One hundred and fifteen teeth were examined, yielding a mean GT of 1.34 mm histologically. US and CBCT underestimated GT (means of 1.25 mm and 1.13 mm, respectively), while TGP overestimated (1.51 mm). Correlations (<i>r</i> = 0.88–0.98) and ICC values (0.73–0.95) indicated strong inter-method agreement. Regression models significantly estimated histological GT from US, CBCT and TGP. A new 1.18 mm cut-off, based on histology, improved diagnostic accuracy over the traditional 1 mm threshold.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>While histology remains the GT reference standard, US, CBCT and TGP achieved clinically acceptable accuracy. US showed the highest agreement with histology, followed by TGP and CBCT. The study supports US as the most practical non-invasive tool, although CBCT and TGP remain viable options. Further clinical validation is recommended, acknowledging the limitations of cadaveric models in reflecting in vivo conditions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 4","pages":"547-560"},"PeriodicalIF":5.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14139","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ridge Augmentation Using a Self-Retaining Block Bone Material in Damaged Extraction Sockets: A Multi-Centre Randomized Controlled Clinical Trial","authors":"Shinyoung Park,&nbsp;Joo-Yeon Lee,&nbsp;Jin-Young Park,&nbsp;Young Woo Song,&nbsp;Jae-Kook Cha,&nbsp;Franz J. Strauss,&nbsp;Seung-Yun Shin,&nbsp;Hyun-Chang Lim,&nbsp;Ronald E. Jung,&nbsp;Ui-Won Jung,&nbsp;Daniel S. Thoma","doi":"10.1111/jcpe.14135","DOIUrl":"10.1111/jcpe.14135","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To compare the dimensional stability of a self-retaining synthetic block bone (srBB) and synthetic bone particles (SBP) for alveolar ridge augmentation (ARA) in damaged extraction sockets.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>ARA was randomly performed in two centres on 57 participants presenting damaged extraction socket in a non-molar tooth: (i) srBB and collagen membrane (srBB group, <i>n</i> = 29) or (ii) SBP and collagen membrane (SBP group, <i>n</i> = 28). Cone beam computed tomography (CBCT) was performed immediately after ARP (baseline, T0) and at 6 months (T1). T0 and T1 CBCTs were superimposed, and horizontal widths (H0–H5), vertical heights and volume changes were assessed using <i>t</i>-test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Due to wound dehiscence, srBB was removed in 10 patients. The change in horizontal width at the most coronal level (H0) was significantly lower for srBB compared to SBP (srBB: 0.8 ± 1.0 mm; SBP: 1.9 ± 2.2 mm, <i>p</i> &lt; 0.05). Significantly less volume decrease was seen at the bucco-coronal level for srBB (srBB: 3.2 ± 0.6 mm³; SBP: 10.4 ± 2.3 mm³, <i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Compared to synthetic bone particles, synthetic bone blocks have the potential to more effectively augment and maintain the coronal horizontal dimension and width of damaged extraction sockets for up to 6 months. However, this advantage is offset by their relatively high rates of early wound dehiscence.</p>\u0000 \u0000 <p>\u0000 <b>Trial Registration:</b> Korean Clinical Research information service (CRIS) (KCT0005462)</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 4","pages":"599-611"},"PeriodicalIF":5.8,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14135","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental Calculus Formation Rate: The Role of Salivary Proteome and Metaproteome","authors":"Wenji Cai,&nbsp;Nadia Dubreuil,&nbsp;Lina Abu Nada,&nbsp;Wen Bo Sam Zhou,&nbsp;Tayebeh Basiri,&nbsp;Amir Hadad,&nbsp;Priti Charde,&nbsp;Maxime Ducret,&nbsp;Faleh Tamimi","doi":"10.1111/jcpe.14142","DOIUrl":"10.1111/jcpe.14142","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Dental calculus accumulation varies across individuals. While various factors contribute to its accumulation, the role of salivary composition remains underexplored. This study aims to compare individuals suffering from rapid rates of dental calculus formation rates with those having slow formation rates in terms of salivary electrochemical properties as well as its proteomic, metaproteomic and elemental composition.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 26 patients with a history of dental calculus were recruited. Saliva samples were collected and evaluated for electrochemical properties as well as elemental, proteomic and metaproteomic composition. Patients were provided scaling treatment to remove all calculus. Six months after the dental cleaning patients were re-assessed for the presence of dental calculus. Based on the dental calculus formation rate participants were categorised into slow (57.7%) and rapid calculus formers (42.3%) that were then assessed for differences in salivary composition.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Rapid calculus formers exhibited a more neutral zeta-potential and lower concentration of salivary calcium ions than their slow-forming counterparts. Proteomic analysis identified 895 proteins across all samples. Of these, 38 proteins were exclusive to the rapid formation group, while 24 proteins were specific to the slow group. The rapid group demonstrated augmented pathways related to cell binding (e.g., cytoskeletal regulation by Rho GTPase and integrin signalling), inflammatory mediation (e.g., chemokine and cytokine signalling) and neurodegenerative disorders (e.g., 5-Hydroxytryptamine degradation, Huntington's disease and Parkinson's disease) and significant enrichment in peptidase inhibitor activity. In contrast, the slow group demonstrated enrichment mainly in immune response. Metaproteomic analysis for salivary bacteria showed significant predominance of <i>Streptococci</i> in the rapid group and elevated levels of <i>Rothia</i> in the slow group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The saliva of patients with rapid calculus formation rates differs from that of patients with slow rates of calculus formation in terms of electrochemical properties as well as proteomic, metaproteomic and elemental composition.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 4","pages":"612-621"},"PeriodicalIF":5.8,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14142","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Collagen Membrane in Vertical Ridge Augmentation Using Ti-Reinforced PTFE Mesh: A Randomised Controlled Trial","authors":"Istvan A. Urban,&nbsp;Matteo Serroni,&nbsp;Debora R. Dias,&nbsp;Zoltán Baráth,&nbsp;Andras Forster,&nbsp;Tiago G. Araújo,&nbsp;Muhammad H. A. Saleh,&nbsp;Alessandro Cucchi,&nbsp;Andrea Ravidà","doi":"10.1111/jcpe.14129","DOIUrl":"10.1111/jcpe.14129","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This non-inferiority randomised clinical trial aimed to compare vertical bone gain (VBG), volumetric bone changes and incidence of complications after vertical ridge augmentation (VRA) using perforated titanium-reinforced dense-polytetrafluoroethylene (PTFE) mesh covered by a collagen membrane (CM) or used alone.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Thirty patients with vertical bone defects were randomly assigned to receive VRA with either PTFE + CM or PTFE alone. Meshes were removed after 9 months. Clinical assessments included complication rates, pseudo-periosteum type and bone density. VBG, effective regeneration rate and the need for additional augmentation were evaluated using CBCT reconstructions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Non-inferiority of PTFE alone compared with PTFE + CM was not demonstrated for absolute and relative VBG (4.5 ± 2.1 mm vs. 4.1 ± 2.7 mm, 79.2% ± 16.6% vs. 85.8% ± 10.6%, respectively), effective regeneration rates (69.3% ± 17.9% vs. 72.3% ± 16.4%, respectively) or complication rates (6.7% in both groups). A higher incidence of type 1 pseudo-periosteum was observed in the PTFE + CM group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The non-inferiority of PTFE alone compared with PTFE + CM for absolute VBG was not established. However, both techniques led to comparable outcomes for VBG, complication rates and bone density. The higher incidence of type 1 pseudo-periosteum and lacking bone volume in the PTFE + CM group suggests that adding a collagen membrane may help prevent soft tissue ingrowth.</p>\u0000 \u0000 <p>\u0000 <b>Trial Registration:</b> Clinicaltrials.gov identification number: NCT04843488</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 4","pages":"575-588"},"PeriodicalIF":5.8,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143417314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Various Detectable Interdental Clinical Attachment Loss Thresholds on the Estimated Prevalence, Stage and Extent of Periodontitis Based on the EFP/AAP Definition","authors":"Wen Meng,&nbsp;Sicheng Wu,&nbsp;Huiwen Chen,&nbsp;Zhongchen Song,&nbsp;Maurizio S. Tonetti,&nbsp;Haixia Lu","doi":"10.1111/jcpe.14131","DOIUrl":"10.1111/jcpe.14131","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To investigate the influence of different detectable interdental clinical attachment loss (CAL) thresholds on estimated prevalence, stage and extent of periodontitis and to assess the influence of three methods in upgrading stage III cases to stage IV in completed surveys.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>National Health and Nutrition Examination Survey 2011–2014 data of 7651 adults were used. The CDC/AAP definition and the EFP/AAP definition with interdental CAL of 1, 2, 3 and 4 mm as the detectable threshold were applied. Three methods (&lt; 10 opposing pairs of natural teeth, &lt; 20 remaining natural teeth or &lt; 10 remaining natural teeth in one jaw) were used to upgrade stage III cases to stage IV.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Estimated periodontitis prevalence was 37.0%, 92.6%, 91.7%, 66.7% and 32.9% using the CDC/AAP definition and the EFP/AAP definition, with 1-, 2-, 3- and 4-mm thresholds, respectively. As the threshold increased, stage I/II cases decreased, resulting in higher estimated disease extent in stage II cases. Compared with the use of 20 remaining teeth, the use of 10 opposing pairs yielded a nearly 4% increase in the estimated prevalence of stage IV cases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Different detectable thresholds and opposing pair approximation methods could influence estimated periodontitis prevalence, stage and extent.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 5","pages":"736-753"},"PeriodicalIF":5.8,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}