Journal of Clinical Periodontology最新文献

{"title":"T2DM-Induced Gut Dysbiosis Exacerbates Periodontitis Through Intestinal Barrier Disruption and Redox Imbalance","authors":"Xulei Yuan,&nbsp;Haotian Gong,&nbsp;Linyue Zhang,&nbsp;Yangbo Liu,&nbsp;Mengjiao Zhou,&nbsp;Yuanyuan Liu,&nbsp;Jiawei Tang,&nbsp;Shengyuan Pan,&nbsp;Xiaohui Xu,&nbsp;Yunji Wang,&nbsp;Ximu Zhang,&nbsp;Tingwei Zhang,&nbsp;Jinlin Song","doi":"10.1111/jcpe.70116","DOIUrl":"10.1111/jcpe.70116","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To investigate the potential role and underlying mechanisms of gut microbiota in type 2 diabetes mellitus (T2DM)-exacerbated periodontitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A T2DM-associated periodontitis model was established in C57BL/6 mice and analysed using multi-omics sequencing (16S rRNA, metagenomics and metabolomics). Faecal microbiota transplantation (FMT) from T2DM donors was carried out in recipient mice to investigate the impact of gut dysbiosis on periodontitis. FMT from healthy donors, supplementation of intestinal barrier protectant or the metabolite oleic acid (OA) was administered to mice with T2DM-associated gut dysbiosis to examine their ameliorative effects on periodontal damage.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>T2DM-associated gut dysbiosis, independent of hyperglycaemia, triggered intestinal barrier disruption, which disturbed systemic redox-related metabolisms and elevated oral oxidative stress, thereby aggravating periodontitis. Restoring gut microbiota via FMT from a healthy donor or protecting the intestinal barrier ameliorated periodontitis. Exogenous supplementary metabolite OA rescued periodontal damage by activating the SIRT1/FoxO1 pathway and enhancing antioxidant enzymes in mice with T2DM-associated gut dysbiosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>T2DM-induced gut dysbiosis exacerbates periodontitis through intestinal barrier disruption and redox imbalance. These findings provide new adjunctive therapeutic perspectives including microbiota restoration, intestinal barrier protection and antioxidant supplementation for managing patients with T2DM-induced periodontitis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 5","pages":"821-833"},"PeriodicalIF":6.8,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147461774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Change in Dental Hygiene Practices and Incidence of Dementia.","authors":"Sangwoo Park,Jonghyeok Lee,Sun Jae Park,Jihun Song,Hye Jun Kim,Sung Min Kim,Hyeokjong Lee,Jaewon Kim,Su Kyoung Lee,Hyun-Jae Cho,Kyae Hyung Kim,Sang Min Park","doi":"10.1111/jcpe.70128","DOIUrl":"https://doi.org/10.1111/jcpe.70128","url":null,"abstract":"AIMTo investigate whether changes in toothbrushing frequency influence the incidence of dementia.MATERIALS AND METHODSThis is a retrospective cohort study using the Korean National Health Insurance Service database. Among 91,978 adults who received two oral health screenings between 2002 and 2005, 74,156 were included after exclusions. Participants were followed until 2019. Participants were categorised into nine groups based on toothbrushing frequency (≤ 1, 2, ≥ 3 times/day) at each screening. Main outcomes such as incidence of overall dementia, Alzheimer's disease (AD) and vascular dementia (VaD) were assessed using Cox proportional hazards models, adjusting for potential confounders.RESULTSIndividuals who increased their toothbrushing frequency to ≥ 3 times/day showed reduced risks of overall dementia (aHR 0.79, 95% CI 0.64-0.99) and AD (aHR 0.76, 95% CI 0.59-0.96). Those who decreased their brushing to ≤ 1 time/day had a higher risk of AD (aHR 1.31, 95% CI 1.05-1.65). A decrease from moderate brushing frequency was associated with elevated VaD risk (aHR 1.32, 95% CI 1.02-1.70).CONCLUSIONImprovements in dental hygiene practices may lower dementia risk, even among those with poor baseline habits. Conversely, lapses in oral care among previously consistent brushers may increase dementia risk.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"3 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147695253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gingival and Periodontal Diseases and Conditions in Children and Adolescents: Consensus Report.","authors":"Iain Chapple,Sotiria Gizani,Mariano Sanz,Dominique Declerck,Phoebus Madianos,Valerie Clerehugh,Monique Danser,Esti Davidovich,Janet Davies,Nikos Donos,Elisabeth Dursun,Elena Figuero,Filippo Graziani,Mervi Gursoy,Soren Jepsen,Clara Joseph,Moritz Kebschull,Norbert Kraemer,Tina Lambrinaki,Rodrigo López,David J Manton,Joerg Meyle,Ana Molina,Lior Shapira,Cheryl Somani,Georgios Tsilingaridis,Svante Twetman,Nicola West,Biniyam Wondimu,Ferranti Wong,David Herrera","doi":"10.1111/jcpe.70033","DOIUrl":"https://doi.org/10.1111/jcpe.70033","url":null,"abstract":"BACKGROUNDThe objectives of this Focused Workshop were to update the epidemiology, aetiology, risk factors, diagnosis and management of gingival and periodontal diseases and conditions in children and adolescents, and to explore the applicability of the 2018 Classification in children and adolescents.METHODSThe Workshop discussions were informed by three specifically commissioned systematic reviews covering gingival and periodontal diseases and conditions, in systemically healthy children and adolescents, or in children and adolescents with systemic conditions.RESULTSOver 70 genetic, congenital and acquired systemic conditions that impact the periodontal tissues were identified, with levels of evidence graded as very low, low or moderate. Gingival diseases and conditions in systemically healthy children and adolescents were identified, alongside local predisposing and systemic modifying factors. Periodontitis and other periodontal conditions in the 2018 Classification System also apply to children and adolescents; however, there are challenges with periodontal probing in the primary and mixed dentition.CONCLUSIONSPeriodontal tissues in children and adolescents differ from those in adults and require special consideration, accounting for their stage of development and predisposing and modifying factors unique to younger patients, which may confound accurate diagnosis, prognostication and management. Specific approaches to screening, examination and treatment are necessary for safe and effective management in this patient group.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"23 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147680375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in Periodontitis by Socioeconomic Status in Brazil: National Surveys 1986–2023","authors":"Roger Keller Celeste, Erika Augustsson, Rafael Aiello Bomfim, Neda Agahi, Alex Nogueira Haas, Johan Fritzell","doi":"10.1111/jcpe.70130","DOIUrl":"https://doi.org/10.1111/jcpe.70130","url":null,"abstract":"Aim To describe trends in periodontitis and trends in socioeconomic inequalities in periodontitis in Brazil from 1986 to 2023. Methods Representative data were obtained from the SBBrasil surveys of 1986, 2002/2003, 2010 and 2022/2023. Periodontitis was assessed by the community periodontal index (CPI), including clinical attachment loss (CAL) at index teeth. The prevalence of individuals with at least one tooth with periodontal probing depth (PPD) ≥ 4 mm was estimated for 16 capitals and CAL ≥ 4 mm for the whole country according to age group, sex, dental visit in the previous year and household income. Trends were estimated using log‐binomial models, using the sampling design. Interactions were tested by covariates and survey year. Results There was a significant decline in the prevalence of periodontitis in all age groups ( <jats:italic>p</jats:italic> &lt; 0.01). From 1986 to 2023, the regression‐estimated decline in PPD prevalence during that period was 43% among teenagers and 36% among adults. CAL‐estimated prevalence reduction was 51% from 2003 to 2023. The decline in prevalence was stronger and statistically significant among adults of higher income groups for PPD and CAL, indicating increasing relative inequalities in age groups. Trends did not differ by sex or dental visit. Conclusions Periodontal health improved overall, but it was unequally distributed, favouring higher income and younger age groups.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"112 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147636055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Suture Diameter and Material on Oral Soft‐Tissue Tearing Behaviour: An In Vitro Study Relevant to Periodontal Plastic Surgery","authors":"Alexander De Greef, Kato Van Caesbroeck, Hanne Langers, Amy Vanrusselt, Pierre Lahoud, Ana Castro, Andy Temmerman","doi":"10.1111/jcpe.70127","DOIUrl":"https://doi.org/10.1111/jcpe.70127","url":null,"abstract":"Aim To assess how suture diameter, material composition and tissue characteristics influence the tension‐to‐tearing behaviour of oral soft tissues, with the objective of optimising atraumatic suturing. Materials and Methods This in vitro cadaver study evaluated 288 standardised porcine oral soft‐tissue specimens (144 gingiva, 144 lining mucosa). Twelve different suture types including four distinct diameters (4–0, 5–0, 6–0, 7–0) and three different materials (polyvinylidene fluoride [PVF], polyamide [PA] and polyglycolic acid [PGA]) were tested using a calibrated Instron microtester. Maximum rupture force (N), failure mode and tissue thickness (mm) were recorded. Statistical analysis relied on three‐way ANOVA, Tukey's post hoc testing and Pearson's correlation ( <jats:italic>α</jats:italic> = 0.05). Results The overall mean maximum rupture force was 5.03 ± 3.00 N. Rupture force increased with suture diameter ( <jats:italic>p</jats:italic> = 0.0001) and differed between materials ( <jats:italic>p</jats:italic> &lt; 0.0001; PGA ≈ PVF &gt; PA). Gingival specimens resisted higher loads than mucosal specimens <jats:italic>(p</jats:italic> = 0.003). Fine sutures (6–0, 7–0) failed mainly by thread rupture, while thicker sutures (4–0, 5–0) caused tissue tearing, supporting the concept of a mechanical safety buffer. PA (6–0) generally preserved tissue integrity, whereas PVF and PGA required 7–0 in delicate mucosa to ensure comparable tissue protection. Tissue thickness correlated positively with rupture force ( <jats:italic>r</jats:italic> = 0.49, <jats:italic>p</jats:italic> &lt; 0.001). Conclusions Finer sutures (6–0 and 7–0) function as protective mechanical fuses, safeguarding delicate tissues during manipulation. PA 6–0 provides reliable protection, while 7–0 PVF and PGA are recommended for fragile mucosa manipulation. These findings provide a biomechanical framework for evidence‐based suture selection in periodontal plastic surgery.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"20 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147636050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Residual Pockets as an Endpoint on Periodontal Disease Progression in Supportive Periodontal Care.","authors":"John Rong Hao Tay,Ethan Ng,Dawn Shu Fen Siow,Stella Jinran Zhan,Seyed Ehsan Saffari,Rodrigo López,Philip M Preshaw","doi":"10.1111/jcpe.70126","DOIUrl":"https://doi.org/10.1111/jcpe.70126","url":null,"abstract":"AIMTo investigate whether the number of residual probing pocket depths (PPDs) ≥ 5 mm predicts periodontitis progression in non-smoking patients undergoing supportive periodontal care (SPC).MATERIALS AND METHODSThis retrospective study included 121 patients (3028 teeth), with Stage III/IV, Grade B/C periodontitis, who completed active periodontal therapy and were enrolled in SPC. Multivariable logistic regression with inverse probability censoring weighting assessed the association between the number of residual sites with PPD ≥ 5 mm at the start of SPC and disease progression at 1-year and 5-year intervals. Receiver operating characteristic (ROC) curve analysis was used to identify optimal thresholds for predicting progression.RESULTSEach additional site with PPD ≥ 5 mm at the start of SPC was associated with higher odds of disease progression (≥ 2 mm PPD increase at any site) after 1 year (adjusted OR: 1.15; 95% CI: 1.05-1.29). For periodontal tooth loss, each additional PPD ≥ 5 mm site increased the odds by 11% over 5 years. ROC analysis suggested that ≥ 6 residual sites provided the best discrimination for predicting 1-year PD progression (AUC: 0.73).CONCLUSIONSix or more residual PPDs ≥ 5 mm at SPC were associated with short-term disease progression, although the performance was modest.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"4 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental Biofilm–Induced Gingivitis in Children and Adolescents Without Known Systemic Involvement: A Systematic Review","authors":"Georgios Tsilingaridis, Nitesh Tewari, Kyriaki Seremidi, William Papaioannou, Rodrigo López","doi":"10.1111/jcpe.70122","DOIUrl":"https://doi.org/10.1111/jcpe.70122","url":null,"abstract":"Aim To synthesize evidence on gingival diseases and conditions in children and adolescents (&lt; 18 years) without known systemic disorder involvement, focusing on their distribution, aetiology, diagnosis, management and oral health–related quality of life (OHRQoL). Materials and Methods A systematic review was carried out following PRISMA guidelines, including PubMed Central, Scopus, EMBASE and LILACS, up to January 2025. Clinical trials and observational studies addressing gingival diseases or conditions in healthy individuals under 18 years were included. Results The search identified 33,180 studies. Title and abstract screening narrowed these to 2264, of which 433 were full‐text‐reviewed. Ultimately, 269 studies, all restricted to biofilm‐induced gingivitis, were included. Considerable heterogeneity was observed in diagnostic criteria and study quality. Dental biofilm–induced gingivitis was common (52%) and associated with poorer OHRQoL. Key determinants for gingival inflammation included socioeconomic status, oral hygiene behaviours, pubertal changes and malocclusion. Based on current evidence, effective management of gingivitis in children should combine supervised toothbrushing with a fluoridated toothpaste and school‐ or caregiver‐based oral health education. Adjunctive use of chlorhexidine may provide additional benefit in certain clinical situations. Conclusion Dental biofilm–induced gingivitis is frequent among children and adolescents and influenced by numerous determinants. Prevention and treatment should emphasise accessible, behaviour‐focused and education‐based strategies for biofilm control.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"273 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147536361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Accuracy of Intraoral Scanning and CBCT Registration in Robotic Computer‐Assisted Implant Surgery for Partially Edentulous Patients: A Randomised Controlled Trial","authors":"Yulan Wang, Jiaxian Chen, Yaoyu Zhao, Bin Shi, Yufeng Zhang, Qi Yan","doi":"10.1111/jcpe.70120","DOIUrl":"https://doi.org/10.1111/jcpe.70120","url":null,"abstract":"Aim To compare the impact of intraoral scanning (IOS) and cone‐beam computed tomography (CBCT) registration on implant positional accuracy in robotic computer‐assisted implant surgery (r‐CAIS). Materials and Methods Patients requiring implant placement in the anterior or premolar regions were enrolled and randomly allocated to either a CBCT group or an IOS group at a 1:1 ratio. Implant positional accuracy was assessed by comparing planned versus actual implant positions using global platform deviation, global apex deviation and angular deviation. Subgroup analyses were performed based on jaw position and span length. The implant survival rate and patient satisfaction were recorded at prosthesis delivery. Statistical analysis was performed using linear mixed‐effects modelling. Results Thirty‐two patients were included (16 patients with 25 implants in each group). In the IOS group, the global platform deviation, global apex deviation and angular deviation were reported as mean ± standard deviation (SD): 0.89 (0.65) mm, 0.95 (0.77) mm and 1.91 (1.98)°, respectively. In the CBCT group, the corresponding values were 0.88 (0.42) mm, 0.98 (0.46) mm and 1.84 (1.46)°. No statistically significant differences were found between IOS and CBCT groups ( <jats:italic>p</jats:italic> &gt; 0.05) regardless of jaw position or edentulous span. The implant survival rate and patient satisfaction were 100% in both groups. Conclusions Preoperative registration using IOS is non‐inferior to CBCT‐based registration in implant accuracy for r‐CAIS, supporting its application as a radiation‐free alternative for registration in partially edentulous patients with sufficient number of stable residual teeth. Trial Registration ChiCTR2400093045","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"4 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147536362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peri‐Implant‐Medication‐Related Osteonecrosis of the Jaws: Epidemiological, Clinical and Radiographic Features—A Retrospective Cohort Study","authors":"Daya Masri, Dror Bar‐Hai, Omar Ghanaiem, Gavriel Chaushu, Liat Chaushu","doi":"10.1111/jcpe.70124","DOIUrl":"https://doi.org/10.1111/jcpe.70124","url":null,"abstract":"Aim To characterize peri‐implant‐medication‐related osteonecrosis of the jaw (PI‐MRONJ) (epidemiological, clinical, and radiographic features) in order to optimise its diagnosis and management. Materials and Methods This is a retrospective cohort study including patients diagnosed with MRONJ that developed spontaneously around previously osseointegrated and loaded dental implants. Data were extracted from medical records. Outcome parameters included the underlying health condition, onset time, age, distinct radiographic features using 3D imaging, severe complications and systemic comorbidities. Patients were categorised into oncologic or osteoporotic groups. Results Forty patients (86 implants) were diagnosed with PI‐MRONJ between 2015 and 2024. The mean age was 72.1. Radiographic features distinct from peri‐implantitis included—osteolysis (80%), the most prevalent radiographic feature, osteosclerosis (57.1%), sequestration (54.3%), periosteal reaction and inferior alveolar canal involvement (30.8% each) and maxillary sinus involvement (77.8% of maxillary cases). A delay in diagnosis (only two cases [5%] were diagnosed at stage 1) was confirmed. Consequently, severe complication rates were high (38.7% for mandible and 55.6% for maxilla). Patients had an average of 3.1 systemic comorbidities. Oncologic patients showed a shorter onset time from antiresorptive treatment to diagnosis (mean 2.8 vs. 6.2 years, <jats:italic>p</jats:italic> &lt; 0.001). Conclusions PI‐MRONJ may clinically and radiographically resemble peri‐implantitis. However, it appears to represent a distinct and underrecognised subtype of MRONJ. Consequently, a delay in diagnosis occurs (stage 3). The advanced diagnostic stage aggravates a high rate of severe complications. A diagnostic flowchart is proposed to aid in differential diagnosis. Advanced age (&gt; 70 years) and distinct radiographic features are suggested as hallmark features.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"21 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147536364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traumatic Occlusion Exacerbates Bone Resorption by Modifying Gene Expression in the Bone Tissue of Ligature‐Induced Periodontitis in Mice","authors":"Yosuke Tsuchiya, Yujin Ohsugi, Tomomitsu Hirota, Yohei Hayashi, Peiya Lin, Yuta Tsukahara, Takanori Iwata, Sayaka Katagiri","doi":"10.1111/jcpe.70112","DOIUrl":"https://doi.org/10.1111/jcpe.70112","url":null,"abstract":"Aim To clarify the molecular mechanisms of occlusal trauma in bone loss through periodontal tissue transcriptome analysis in mice with periodontitis and traumatic occlusion. Materials and Methods Ligature‐induced periodontitis (Li) and composite resin‐induced traumatic occlusion (Tra) mouse models were established (control [Co], Li, Tra and LiTra). Bone resorption was evaluated using micro‐computed tomography (micro‐CT). RNA‐sequencing was conducted on gingiva, bone and periodontal ligament from all groups 3 days post induction. For long‐term evaluation, the Co and Tra groups were maintained for 8 weeks and then analysed using micro‐CT and qRT‐PCR. Results Traumatic occlusion alone, sustained for 8 weeks, did not directly induce bone resorption; however, it significantly exacerbated bone resorption in mice with periodontitis. Cytokine–cytokine receptor interactions and Toll‐like receptor signalling pathways were up‐regulated in LiTra bone tissue. <jats:italic>Il11, Il1rl1</jats:italic> and <jats:italic>Mmp3</jats:italic> , associated with inflammation and bone metabolism, were more highly expressed in the LiTra group than in the Li group. TNF‐α signalling via NFκB and inflammatory response gene sets were enriched in the bone tissue of LiTra group. Conclusions Traumatic occlusion accelerates bone resorption in ligature‐induced periodontitis but does not independently cause significant bone loss. Occlusal trauma enhances the expression of inflammation‐related genes, especially in bone with periodontitis.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"90 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147507925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}