Journal of Clinical Periodontology最新文献

{"title":"Correction to ‘The Effect of Orthodontic Tooth Movement on Intrabony Periodontal Defects After Guided Tissue Regeneration. Part I: Human Histologic Evaluation of 20 Consecutive Cases’","authors":"","doi":"10.1111/jcpe.70178","DOIUrl":"10.1111/jcpe.70178","url":null,"abstract":"<p>\u0000 <span>Nagy, P.</span>, <span>P. Windisch</span>, <span>B. Nemes</span>, <span>P. Schupbach</span>, <span>A. Dobos</span>, and <span>A. Stavropoulos</span>. <span>The Effect of Orthodontic Tooth Movement on Intrabony Periodontal Defects After Guided Tissue Regeneration. Part I: Human Histologic Evaluation of 20 Consecutive Cases</span>. <i>Journal of Clinical Periodontology</i> <span>2026</span>. https://doi.org/10.1111/jcpe.70134.\u0000 </p><p>In the published article, the ethics approval information, informed consent statement, and clinical trial registration number were inadvertently omitted from Section 2.1 (Study sample) of the Materials and Methods section.</p><p>The beginning of Section 2.1 should read as follows:</p><p>2.1 Study sample</p><p>A total number of 36 patients were selected from among those seeking periodontal care at the Department of Periodontology, Semmelweis University, and were included in a randomized clinical trial (RCT). Histological analysis was predefined in the study protocol and limited to the first 20 consecutively enrolled patients due to logistical, ethical, and financial considerations (study design is included in Part II). The study protocol was approved by the Regional and Institutional Committee of Science and Research Ethics of Semmelweis University (approval No. 90/2015) and was conducted in accordance with the Declaration of Helsinki. All participants provided written informed consent prior to enrollment. The randomized clinical trial was registered at ClinicalTrials.gov (NCT04896450). Every candidate met the following criteria:</p><p>We apologize for this error.</p>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 10","pages":""},"PeriodicalIF":8.3,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70178","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148758326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Periodontitis in Africa: A Systematic Review and Meta-Analysis of Epidemiological Studies Up to 2025","authors":"Abdoulaziz Diarra,&nbsp;Hamoun Sabri,&nbsp;Estelle Flore Bandre,&nbsp;Estelle Noëla Hoho Youl,&nbsp;Kevimy Agossa,&nbsp;Olivier Huck","doi":"10.1111/jcpe.70157","DOIUrl":"10.1111/jcpe.70157","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To provide updated and comprehensive estimates of the changes in prevalence of periodontitis in Africa, based on epidemiological data up to 2025.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A systematic literature search was conducted through MEDLINE, Embase, Scopus, Web of Science and Google Scholar. Meta-analyses were performed to estimate the prevalence of periodontitis across population subgroups and diagnostic criteria.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty-three studies met the inclusion criteria. Among children (&lt; 10 years), prevalence was 1.9% (95% CI: 0.9%–3.9%; <i>I</i>² = 77.7%) and among adolescents (10–19 years), it was 11.2% (95% CI: 4.7%–24.3%; <i>I</i>² = 98.1%). In young adults (20–25 years), prevalence was 12.8% (95% CI: 2.8%–42.8%; <i>I</i>² = 98.9%), in adults (25–49 years), 20.0% (95% CI: 11.9%–31.7%; <i>I</i>² = 99.1%) and in older adults (≥ 50 years) 23.1% (95% CI: 12.2%–39.3%). Substantial variation was observed across diagnostic definitions and thresholds. Geographic region and urban versus rural origin emerged as significant modifiers of prevalence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Epidemiological studies on periodontitis in Africa often overrepresent younger populations and rely on non-confident diagnostic criteria, likely underestimating true prevalence. Nevertheless, updated estimates suggest a concerning burden among younger age groups. More comprehensive research is needed to enhance the accuracy of prevalence estimates of periodontitis in Africa.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 10","pages":"1494-1512"},"PeriodicalIF":8.3,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70157","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148400837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wound Healing Patterns of PRF and PRGF Versus a Collagen-Based Substitute and Spontaneous Healing—A Randomised Controlled Clinical Trial Assessing Wound Closure of an Experimental, Standardised Palatal Defect","authors":"Stefan P. Bienz,&nbsp;Anne C. Fischer,&nbsp;Leonardo Mancini,&nbsp;Franz J. Strauss,&nbsp;Raphael M. Ferrari,&nbsp;Sonja Hitz,&nbsp;Ronald E. Jung,&nbsp;Daniel S. Thoma","doi":"10.1111/jcpe.70164","DOIUrl":"10.1111/jcpe.70164","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To evaluate wound-healing progression among platelet-rich fibrin (PRF), plasma rich in growth factors (PRGF), a collagen-based wound dressing (CS = collagen substitute) and spontaneous healing (control), assessed by percentage of remaining open wound area and patient-reported pain.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Twenty participants each received four standardised palatal wounds (6 mm × 3 mm) and were randomly assigned to PRF, PRGF, a collagen substitute or spontaneous healing as control. All dressings were secured with criss-cross sutures. Standardised clinical photographs and pain assessments were obtained at baseline and on postoperative days 2,5,7,9, 12 and 14. Parametric and nonparametric models for longitudinal data were used to compare outcomes, accounting for within-subject correlation of repeated measurements.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Open wound area decreased across all groups throughout the 14-day period. Some defects enlarged transiently at Day 2, and the greatest differences between the groups were observed on Day 7 (35.7%–47.0% of wound remaining). Pain scores decreased significantly over time in all groups, with no statistically significant differences between treatments (<i>p</i> &gt; 0.05). Anterior defects tended to be perceived as more painful than posterior defects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Spontaneous healing resulted in slightly faster reduction of remaining open wound area than PRF, PRGF or the collagen substitute, with comparable postoperative pain levels. In standardised defects in healthy individuals, PRF, PRGF and collagen substitutes demonstrate minimal additional benefit for soft-tissue healing. Further studies are warranted to determine whether benefits emerge in larger wounds or in patients with compromised healing.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 10","pages":"1565-1574"},"PeriodicalIF":8.3,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70164","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148673655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost Consequence Analysis of Non-Surgical Treatment Approaches for Patients With Periodontitis","authors":"Anna Liss,&nbsp;Max Petzold,&nbsp;Cristiano Tomasi,&nbsp;Kajsa H. Abrahamsson,&nbsp;Maria Welander","doi":"10.1111/jcpe.70154","DOIUrl":"10.1111/jcpe.70154","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To analyse and compare cost consequences of two evidence-based non-surgical periodontal treatment protocols performed by dental hygienists (DHs) in general practice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Six-hundred and fifteen patients were included. Treatment approaches compared were (i) conventional non-surgical therapy (CNST), often performed at multiple sessions, and (ii) a ‘full-mouth’ concept called guided periodontal infection control (GPIC), with initial focus on patient education followed by one session of ultrasonic instrumentation. A cost consequence analysis was conducted regarding the two approaches, including treatment costs, travelling costs and productivity costs, as well as non-monetary consequences (closed pockets and bleeding on probing). In data analysis, the 95% confidence intervals were obtained using the percentile method based on 5000 bootstrap replications.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Treatment costs were higher for CNST compared to GPIC by €60 (€359.5 [95% CI: 345.5–374.2] vs. €299.4 [95% CI: 289.3–309.1]). Productivity costs related to treatment were also greater in CNST by +€15. Travel costs showed minor differences (+€1 for CNST). Non-monetary outcomes showed no significant differences between groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>CNST was more costly than GPIC while maintaining comparable clinical outcomes at 6 months. When designing policy and practice for non-surgical treatment approaches, both evidence-based practice and how shared resources are best used should be acknowledged.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 10","pages":"1557-1564"},"PeriodicalIF":8.3,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70154","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148283432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Horizontal Ridge Augmentation Using an rhBMP-2 Loaded Volume-Stable Collagen Matrix Compared to Guided Bone Regeneration: A Preclinical In Vivo Study","authors":"Jin-Young Park,&nbsp;Gi-Seo Song,&nbsp;Seung-Hyun Park,&nbsp;Lorenzo Tavelli,&nbsp;David T. Wu,&nbsp;Daniel S. Thoma,&nbsp;Ronald E. Jung,&nbsp;Ui-Won Jung,&nbsp;Jae-Kook Cha","doi":"10.1111/jcpe.70161","DOIUrl":"10.1111/jcpe.70161","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To investigate whether incorporation of recombinant human bone morphogenetic protein-2 (rhBMP-2) into a volume-stable collagen matrix (VCMX) enhances horizontal ridge augmentation compared with VCMX alone or guided bone regeneration (GBR).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Chronic horizontal ridge defects were created in five canines. Sites randomly received: (1) control, (2) VCMX, (3) VCMX with rhBMP-2 or (4) GBR (deproteinised bovine bone mineral with a collagen membrane). After 8 weeks, outcomes were assessed by profilometry, micro-computed tomography and histomorphometry.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>VCMX/rhBMP-2 showed significantly greater new bone volume (181.50 ± 142.32 mm³) than GBR (36.06 ± 25.86), VCMX (8.40 ± 6.15) and control (7.32 ± 4.03 mm³) (all <i>p</i> &lt; 0.05). Histometric new bone thickness was greater in VCMX/rhBMP-2 than GBR at all levels (crestal: 2.31 ± 1.93 vs. 1.09 ± 0.41 mm; <i>p</i> = 0.038). Coronal contour gain was higher in VCMX/rhBMP-2 than VCMX (<i>p</i> = 0.007), with no difference versus GBR (<i>p</i> = 0.654). At middle and apical levels, all augmentation groups exceeded control (<i>p</i> ≤ 0.011).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>RhBMP-2 delivered via VCMX enhanced horizontal bone regeneration with augmented dimensions comparable to GBR.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 10","pages":"1610-1620"},"PeriodicalIF":8.3,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70161","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148400838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Tooth Units, Oral Disease Status and Dietary Quality in a Representative US Population","authors":"Yu Xie,&nbsp;Mengning Bi,&nbsp;Xiaoyu Yu,&nbsp;Jie Shen,&nbsp;Hairui Li,&nbsp;Yuan Li,&nbsp;Andrea Roccuzzo,&nbsp;Changzheng Yuan,&nbsp;Maurizio S. Tonetti","doi":"10.1111/jcpe.70165","DOIUrl":"10.1111/jcpe.70165","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To investigate how functional tooth units (FTUs) and oral conditions are associated with dietary quality through multidimensional measures within a unified analytic framework.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Data were drawn from 6291 adults in the 2011–2014 National Health and Nutrition Examination Survey. Dentition status was assessed using FTUs and tooth count, and oral disease status was classified based on both untreated caries and periodontitis. Dietary outcomes derived from two 24-h dietary recalls included the Healthy Eating Index-2020 (HEI-2020), Dietary Approaches to Stop Hypertension index (DASH), alternate Mediterranean diet score (MED), Dietary Inflammation Index (DII), food groups and nutrient intakes. Distributional differences and associations between oral conditions and dietary outcomes were assessed using survey-weighted analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Participants with adequate FTUs had higher dietary quality than participants with impaired FTUs or edentulous participants. In fully adjusted models, each additional FTU was associated with higher HEI-2020 scores (β = 0.41, 95% CI: 0.29–0.54), lower DII scores (β = −0.06, 95% CI: −0.09 to −0.04) and more reported food items (β = 0.09, 95% CI: 0.04–0.14). Among dentate adults, untreated caries status was linked to less favourable dietary profiles after FTUs adjustment. In disease extent analyses, Decay% was associated with higher dietary quality indices than Decay + Filling% or periodontal parameters. After full adjustment, only Decay% remained significantly associated with added sugar intake in the analyses for foods and nutrients. In addition, oral conditions were significantly associated with overall food or nutrient variation, whereas sociodemographic factors accounted for a larger proportion of overall variation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Oral conditions show distinct associations with dietary quality. Impaired FTUs are linked to poorer dietary quality; coexisting caries and periodontitis are associated with the least favourable dietary quality. Oral conditions may help identify adults with less favourable dietary profiles, although sociodemographic factors explained greater overall dietary variation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 10","pages":"1529-1545"},"PeriodicalIF":8.3,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70165","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148432586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soft-Tissue Augmentation During Implant Placement in the Aesthetic Zone: Clinical, Radiographic, Histological and Patient-Reported Outcomes From a Randomised Controlled Trial Using Connective Tissue Graft and a Volume-Stable Collagen Matrix","authors":"Louiza Papantonatou,&nbsp;Leonidas Batas,&nbsp;Antigoni Delantoni,&nbsp;Eleutherios Anagnostou,&nbsp;Ioannis Vouros","doi":"10.1111/jcpe.70177","DOIUrl":"10.1111/jcpe.70177","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate the clinical, radiographic, histological and patient-reported outcome measures (PROMs) of soft-tissue augmentation (STA) during implant placement in the aesthetic zone using a connective tissue graft (CTG) or a volume-stable collagen matrix (VCMX).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>In this three-arm randomised controlled trial, 25 patients were allocated to VCMX, SCTG, or no augmentation (control). Soft-tissue thickness (STT) was assessed by ultrasonography, and buccal bone thickness (BBT) by CBCT, at baseline and 6 months. Clinical parameters, PROMs and histological findings were recorded. Statistical analysis was performed at the patient level using repeated-measures general linear models, accounting for within-subject variability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Both VCMX and SCTG resulted in significant increases in STT compared with control (<i>p</i> &lt; 0.001). Numerically greater STT gains were observed in the VCMX group. BBT decreased significantly over time in all groups, with no significant differences between treatments. PROMs were comparable, although CTG was associated with slightly higher morbidity. Histological analysis showed favourable integration of both grafting materials.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>STA significantly increased STT but did not prevent buccal bone remodelling. Within the study limitations, both augmentation approaches were associated with increased STT compared with no augmentation. Further well-designed studies are required to confirm these findings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>This study is registered at ClinicalTrials.gov (ClinicalTrials.gov Identifier: NCT06622759; URL: https://clinicaltrials.gov/study/NCT06622759)</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 10","pages":"1585-1595"},"PeriodicalIF":8.3,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70177","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148596268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large Language Models and Retrieval-Augmented Platforms for the Diagnosis and Management of Periodontal Diseases: A Blinded Expert-Rated Comparative Study of 11 Systems","authors":"Yaniv Mayer,&nbsp;Bertha Demetriou,&nbsp;Giulio Rasperini,&nbsp;Eran Gabay,&nbsp;Rok Gašperšič,&nbsp;Darko Božić,&nbsp;Javier Calatrava,&nbsp;Ofir Ginesin,&nbsp;Hadar Zigdon Giladi,&nbsp;Ricardo Faria Almeida","doi":"10.1111/jcpe.70160","DOIUrl":"10.1111/jcpe.70160","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To compare retrieval-augmented systems with general-purpose large language models (LLMs) on standardised periodontal clinical vignettes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Eleven AI systems were evaluated: nine general-purpose LLMs, one general-purpose retrieval-augmented platform (Perplexity) and one medical-domain retrieval-augmented platform (OpenEvidence). Each responded to 30 synthetic vignettes covering acute, chronic and complex periodontal scenarios. Six blinded periodontists scored responses on a 5-point Likert scale for accuracy, safety, freedom from hallucinations and completeness in a randomised block design. Friedman and Conover–Iman tests with Holm correction were applied; mixed-effects and ordinal models served as sensitivity analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At least one parameter scored dangerous (≤ 2) in 3.3%–46.7% of responses across platforms, despite mean composite scores (3.28–4.86) exceeding the rubric midpoint of 3.0. Between-model differences were significant (<i>p</i> &lt; 0.001), with a small-to-medium overall effect (Kendall's <i>W</i> = 0.17) and large within-category effects (<i>W</i> up to 0.82). Perplexity, OpenEvidence and Claude 4.7 Opus formed a top tier.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Retrieval-augmented systems rated highest, but this advantage was confounded with response length. The dangerous-response spread argues against undifferentiated use. These tools should assist, not replace, specialist judgement.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 10","pages":"1546-1556"},"PeriodicalIF":8.3,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70160","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148388622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Therapy for Peri-Implantitis Using Deproteinised Bovine Bone Mineral With 10% Collagen, Enamel Matrix Derivative and Doxycycline: A Prospective Cohort 10-Year Implant Study","authors":"Faustino Mercado,&nbsp;Saso Ivanovski","doi":"10.1111/jcpe.70175","DOIUrl":"10.1111/jcpe.70175","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To assess 10-year implant survival following surgical management of peri-implantitis using deproteinised bovine bone mineral with 10% collagen (DBBMC), enamel matrix derivative (EMD) and doxycycline powder.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>The original population comprised 30 non-smoking, periodontally stable patients (mean age = 44.9 ± 11 years; 64% female; full-mouth plaque and bleeding score &lt; 20%, no bleeding residual periodontal pockets ≥ 4 mm), each with a single peri-implantitis-affected implant (bleeding on probing, probing depth &gt; 6 mm, ≥ 20% radiographic bone loss, implants in function ≥ 2 years). The surgical procedure involved implant surface decontamination with 24% EDTA followed by defect fill with DBBMC/EMD/doxycycline mixture. Patients underwent individualised supportive peri-implant therapy (SPIT) comprising regular clinical monitoring, professional cleaning and antimicrobial protocols for 10 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty-nine of the 30 implants survived (96.6% survival rate). Mean probing depth decreased from 8.90 ± 1.9 mm to 3.06 ± 0.98 mm; radiographic bone loss improved from 57% ± 16.5% to 13% ± 2.5%. During 10-year SPIT, 12 implants required adjunctive azithromycin. Fifty-eight percent achieved the successful treatment outcome criterion (SOTC: probing depth &lt; 5 mm, no bone loss 10% from baseline, absence of bleeding on probing/suppuration and recession &lt; 0.5 mm anterior/1.5 mm posterior implants).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Surgical management of peri-implantitis combined with DBBMC/EMD/doxycycline and personalised SPIT achieved high long-term implant survival and stable clinical outcomes over 10 years.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 10","pages":"1575-1584"},"PeriodicalIF":8.3,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70175","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"METTL14-Mediated m6A Modification of NEAT1_2 Releases YBX1 From Paraspeckles to Exacerbate Periodontitis","authors":"Juan Du,&nbsp;Zi'ang Cheng,&nbsp;Yu Zhang,&nbsp;Yaqi Cong,&nbsp;Donghua Guo,&nbsp;Yi Zhou,&nbsp;Jing Huang","doi":"10.1111/jcpe.70155","DOIUrl":"10.1111/jcpe.70155","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To investigate the role and epigenetic mechanism of methyltransferase 14 (METTL14)-mediated N6-adenylate methylation (m6A) modification of long non-coding RNAs (lncRNAs) in the pathogenesis of periodontitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A periodontal ligament–targeted <i>Mettl14</i>-cKO mouse model (<i>Gli1-Cre</i>^<i>ERT2</i><i>;Mettl14</i>^<i>fl/fl</i>) was established using silk ligatures. Human periodontal ligament cells (PDLCs) were used for in vitro assays. MeRIP-seq, RNA-seq, RNA pull-down, mass spectrometry, RIP Co-IP and CUT&amp;Tag were performed to elucidate the METTL14–NEAT1_2–YBX1 axis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>METTL14 expression was significantly up-regulated in inflamed periodontal tissue. METTL14 deficiency alleviated alveolar bone destruction and suppressed IL-6 expression in vivo and in vitro. Mechanistically, METTL14 catalysed m6A modification of nuclear paraspeckle assembly transcript 1_2 (NEAT1_2), facilitating NEAT1_2 degradation. NEAT1_2-organised paraspeckles (PSPs) sequestered the transcription factor Y-box binding protein 1 (YBX1) under normal conditions. In periodontitis, METTL14-induced NEAT1_2 down-regulation triggered PSP disassembly, resulting in the translocation of YBX1 to the nucleus and increased IL-6 transcription. Neat1_2 knockdown exacerbated bone loss and neutralised the protective effect of METTL14 deficiency.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>METTL14-mediated m6A modification exacerbates periodontitis by disrupting NEAT1_2-dependent PSP sequestration of YBX1. This study identifies the METTL14–NEAT1_2 axis as a critical regulator of periodontal inflammation, suggesting that METTL14 is a potential therapeutic target for periodontitis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 10","pages":"1621-1634"},"PeriodicalIF":8.3,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148271504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}