Journal of Clinical Periodontology最新文献

{"title":"Postoperative Sequelae and Complications of Alveolar Ridge Augmentation With Simultaneous Implant Placement. A Retrospective Cohort‐Based Predictive Risk Modelling","authors":"Muhammad H. A. Saleh, Hend Abulatifa, Francesco Fanelli, Abdusalam E. Alrmali, Asmaa W. Issa, Hom‐Lay Wang, Giuseppe Troiano","doi":"10.1111/jcpe.70196","DOIUrl":"https://doi.org/10.1111/jcpe.70196","url":null,"abstract":"Aims To quantify the incidence and develop predictive models for postoperative sequelae and complications (POSC) and the need for additional grafting after alveolar ridge augmentation with simultaneous implant placement (SARA). Methods This longitudinal retrospective cohort included adults with ridge deficiencies who underwent SARA with implant placement from 2019 to 2024 at the University of Michigan Graduate Periodontics Clinic. One site per patient was analysed. Complications were classified according to the severity of consequences and need for further intervention. Univariable and multivariable logistic regression models were performed with stepwise refinement. Firth penalized logistic regression was used when sparse data/separation were present. Model discrimination (area under the curve, AUC) and calibration (Hosmer–Lemeshow, HL) were assessed; ROC‐derived thresholds were used to report operating characteristics. Results Three‐hundred and ninety‐one patients were included. Systemic comorbidities were documented in 48.6%. Postoperative sequelae occurred in 31.5% of patients, and complications occurred in 25.8%. Membrane exposure was associated with vertical/combined defects (adjusted odds ratio [aOR] 2.52; 95% CI: 1.50–4.23). Microsurgical technique was associated with lower odds of incision‐line dehiscence (aOR 0.76; 95% CI: 0.57–1.00; <jats:italic>p</jats:italic> = 0.049). Prolonged swelling was associated with flap extension (aOR 1.21 per tooth site; 95% CI: 1.04–1.39). Additional grafting occurred in 6.14% and was associated with clinical attachment loss (CAL ≥ 5 mm on adjacent tooth [OR 14.07; 3.79–52.18; <jats:italic>p</jats:italic> &lt; 0.001]), current smoking (OR 5.11; 1.38–18.95; <jats:italic>p</jats:italic> = 0.015) and long‐term systemic corticosteroid use (OR 1.61; 1.04–2.51; <jats:italic>p</jats:italic> = 0.035) (AUC 0.744; HL <jats:italic>p</jats:italic> = 0.5103). Conclusion Postoperative sequelae were more frequent than true complications, and the need for additional grafting was uncommon. Complications were mainly associated with defect morphology and surgical technique rather than systemic comorbidities.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"75 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148957988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peri‐Implantitis‐Associated Bacteria Activate the STAT3 Pathway in Oral Epithelial Cells","authors":"Marion Arce, Joaquin Espinoza‐Arrue, Daniel Sansores‐España, Matias Morales, Mauricio J. Farfan, Mariano Sanz, Loreto Abusleme, Nicolas Dutzan","doi":"10.1111/jcpe.70199","DOIUrl":"https://doi.org/10.1111/jcpe.70199","url":null,"abstract":"Aim To assess STAT3 activation in peri‐implantitis tissues and to evaluate the STAT3‐associated response of oral epithelial cells (OECs) to peri‐implantitis‐associated bacteria. Methods In this cross‐sectional study, gingival tissue biopsies were obtained from subjects with gingival health, periodontitis and peri‐implantitis. pSTAT3/STAT3 and STAT3 pathway‐dependent mRNA levels were analysed, and pSTAT3‐positive cells were assessed by immunofluorescence. Additionally, OECs were stimulated with <jats:styled-content style=\"fixed-case\"> <jats:italic>S. sanguinis</jats:italic> </jats:styled-content> , <jats:styled-content style=\"fixed-case\"> <jats:italic>P. gingivalis</jats:italic> </jats:styled-content> and <jats:italic> <jats:styled-content style=\"fixed-case\">F. nucleatum</jats:styled-content> , </jats:italic> as well as with bacterial communities from the three conditions. STAT3 pathway–associated mRNA levels and the pSTAT3/STAT3 ratio were evaluated. Finally, the effect of pSTAT3 inhibition was analysed. Results Increased STAT3 pathway activation was observed in peri‐implantitis tissues, characterised by a higher pSTAT3/STAT3 ratio and elevated <jats:italic>IL6</jats:italic> and <jats:italic>SOCS3</jats:italic> mRNA levels. Compared with healthy gingival tissues and periodontitis, peri‐implantitis tissues exhibit a higher proportion of pSTAT3‐positive epithelial cells. <jats:styled-content style=\"fixed-case\"> <jats:italic>P. gingivalis</jats:italic> </jats:styled-content> and <jats:styled-content style=\"fixed-case\"> <jats:italic>F. nucleatum</jats:italic> </jats:styled-content> increased the mRNA of the STAT3‐associated <jats:italic>IL6</jats:italic> , <jats:italic>IL23A</jats:italic> , <jats:italic>SOCS3</jats:italic> , chemoattractant‐associated <jats:italic>CXCL8</jats:italic> , <jats:italic>IL36G</jats:italic> and inflammation‐associated <jats:italic>IL1B</jats:italic> , <jats:italic>TNF</jats:italic> A. Notably, STAT3 inhibition decreased the mRNA levels of STAT3‐downstream cytokines and the neutrophil chemoattractants <jats:italic>CXCL8</jats:italic> and <jats:italic>IL36G</jats:italic> . Conclusion The STAT3 pathway is activated in peri‐implantitis and in OECs and is elicited by peri‐implantitis‐associated bacteria, contributing to a pro‐chemotactic epithelial environment, positioning this pathway as a key area of interest for future research into the molecular mechanisms underlying both conditions.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"51 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148915410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alveolar Bone Regeneration Using 3D‐Printed, Patient‐Specific, Resorbable PCL Scaffold: Prospective Cohort Study","authors":"Jamil Alayan, Reuben Staples, Sašo Ivanovski","doi":"10.1111/jcpe.70197","DOIUrl":"https://doi.org/10.1111/jcpe.70197","url":null,"abstract":"Aim To evaluate clinical feasibility of 3D‐printed, patient‐specific, polycaprolactone (PCL) resorbable scaffolds for staged alveolar ridge augmentation. Materials and Methods Ten patients requiring staged bone augmentation underwent digital planning to virtually reconstruct the defect to its original contour. Patient‐specific medical‐grade PCL scaffolds were then fabricated using 3D printing and sterilised using γ irradiation. Following surgical access of the defect site, the scaffolds were loaded with a composite graft of autogenous bone, deproteinised bovine bone mineral and injectable platelet‐rich fibrin, and covered with a resorbable collagen membrane. Clinical reviews were performed at 1, 3 and 8 weeks. Guided implant placement was carried out 6 months later. Primary outcome was volume gain. Secondary outcomes included linear ridge changes, surgical and postoperative parameters, implant feasibility and patient‐reported outcomes. Results Mean volumetric bone gain was 513.1 ± 321.4 mm <jats:sup>3</jats:sup> , or 112.0% ± 35.0% of the original defect. Mean linear bone gain was 2.2 mm horizontally and 4.7 mm vertically. All implants achieved primary stability with minimal additional augmentation or deviation from the initial digital plan. Surgically, there was one case of transient altered sensation and one case of wound dehiscence. Postoperative pain (worse pain) reached moderate levels that significantly declined to mild levels after Day 4; interference to daily activities significantly reduced by Day 6 and analgesic (NSAIDs) consumption by Day 8. Conclusion Patient‐specific PCL scaffolds demonstrated predictable bone regeneration of moderate size defects with minimal complications, which facilitated precise implant placement, supporting scaffold‐guided bone regeneration as a clinically viable and personalised approach in alveolar bone reconstruction.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"199 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148909186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Acute Periodontal Conditions-The EFP S2k Level Clinical Practice Guideline.","authors":"David Herrera, Panos N Papapanou, Iain Chapple, Moritz Kebschull, Wim Teughels, Maurizio S Tonetti, Mariano Sanz, Anton Sculean, Mario Aimetti, Ivan Alajbeg, Georgios N Belibasakis, Juan Blanco, Ellen Bol-van den Hil, Nagihan Bostanci, Philippe Bouchard, Darko Božić, Nurcan Buduneli, Dagmar Fosså Bunæs, Elena Calciolari, Maria Clotilde Carra, Laura Ceballos, Tali Chackartchi, Raluca Cosgarea, Monique Danser, Jan Derks, Nicola Discepoli, Henrik Dommisch, Nikos Donos, Christoph Dörfer, Peter Eickholz, Bahar Eren Kuru, Ricardo Faria Almeida, Roberto Farina, Elena Figuero, Helena Francisco, Helena Fransson, Maria L Geisinger, Moshe Goldstein, Marjolaine Gosset, Filippo Graziani, Ulvi K Gursoy, Sören Jepsen, Niklaus P Lang, Bruno Loos, Rodrigo López, Phoebus Madianos, Paula Matesanz, Marco Meleti, Joerg Meyle, Michele Davide Mignogna, Ana Molina, Eduardo Montero, Luigi Nibali, Andrea Pilloni, Ioannis Polyzois, Philip Preshaw, Mia Rakic, Nerea Sánchez, Ignacio Sanz-Sánchez, Lior Shapira, Dagmar Else Slot, Andreas Stavropoulos, Jean Suvan, Selena Toma, Cristiano Tomasi, Leonardo Trombelli, Fridus van der Weijden, Spyros Vassilopoulos, Nicola West, Asaf Wilensky, Peter Windisch, Ezgi Yesiltan, Evangelia P Zampa","doi":"10.1111/jcpe.70166","DOIUrl":"https://doi.org/10.1111/jcpe.70166","url":null,"abstract":"<p><strong>Background: </strong>The European Federation of Periodontology (EFP) has developed Clinical Practice Guidelines (CPGs) for the treatment of periodontitis and for the management of peri-implant diseases. In accordance with the 2018 Classification, acute periodontal conditions are characterised by rapid-onset pain or discomfort, tissue destruction and infection. Therefore, the development of a CPG to guide patients and clinicians in their management is justified.</p><p><strong>Aim: </strong>To develop an S2k-level CPG for the management of acute periodontal conditions, necrotising periodontal diseases, periodontal abscesses and acute manifestations of endodontic-periodontal lesions.</p><p><strong>Methods: </strong>This S2k-level CPG was developed by the EFP, following methodological guidance from the Association of Scientific Medical Societies in Germany and the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) process. A rigorous and transparent process included synthesis of relevant research in two commissioned systematic reviews, evaluation of the quality and strength of evidence, formulation of specific recommendations and a structured consensus process involving leading experts and a broad base of stakeholders. Recommendations were based on the best available evidence, combined with structured expert consensus, particularly in areas where direct evidence remains scarce.</p><p><strong>Results: </strong>The S2k-level CPG for the management of acute periodontal conditions presents a structured approach, grouping the recommendations in three successive steps: (1) confirming diagnosis, following the case definitions of the 2018 classification; (2) initial treatment, to control the acute condition including pain and active tissue destruction; and (3) subsequent treatments, to manage the pre-existing conditions and prevent the risk of disease recurrence and/or control the potential sequelae.</p><p><strong>Conclusion: </strong>The present S2k-level CPG informs clinical practice, health systems, policymakers and, indirectly, the public on the available and most effective interventions in the management of acute periodontal conditions.</p>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":" ","pages":""},"PeriodicalIF":8.3,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148912263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct Microbial and Host Proteome Signatures Relate to Proteolytic Activity in Gingival Crevicular Fluid in an Exploratory Study of Patients With Periodontitis.","authors":"Miguel Carda-Diéguez, Stefan Rüdiger, Gunnel Svensäter, Henrik Jansson, Tirthankar Mohanty, Yashuan Chao, Christofer Karlsson, Johan Malmström, Oonagh Shannon, Álex Mira, Julia R Davies","doi":"10.1111/jcpe.70186","DOIUrl":"10.1111/jcpe.70186","url":null,"abstract":"<p><strong>Aim: </strong>Risk assessment tools for periodontitis lack sufficient precision to predict disease progression. The aim of this exploratory study was to evaluate proteolytic activity (PA) in gingival crevicular fluid in relation to clinically assessed progression risk, microbial community composition and host proteome.</p><p><strong>Materials and methods: </strong>Samples were collected from 109 patients with periodontitis and stratified into high and low PA groups using a fluorescent substrate. Microbial composition was analysed via 16S rRNA gene sequencing, and host proteomic profiles were determined using mass spectrometry.</p><p><strong>Results: </strong>Forty-one of 42 patients in the high PA group were clinically classified as high-risk, while the low-activity group included both low- and high-risk individuals. High-activity samples displayed greater microbial diversity and enrichment of proteolytic species including Fusobacterium nucleatum, Porphyromonas gingivalis and Treponema denticola. Of the 235 differentially expressed host proteins, high-activity samples had elevated markers of inflammation and neutrophil-mediated immunity, whereas low-activity samples were enriched in protease inhibitors, indicating more effective regulation of tissue degradation.</p><p><strong>Conclusions: </strong>Small-volume gingival crevicular fluid sampling allows integrated analysis of microbial and host signatures that provide insight into the pathobiology of periodontitis. PA stratifies patients according to these microbial and host proteome signatures.</p>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":" ","pages":""},"PeriodicalIF":8.3,"publicationDate":"2026-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polygenic Risk Modelling in Periodontitis: Insights From a Feasibility Study of 4243 European Cases and Current Limitations.","authors":"Gesa M Richter, O Mercy Akinloye, M Kamal Nasr, Birte Holtfreter, Alicia de Coo, Silvia Diz De Almeida, Bruno G Loos, Søren Jepsen, Henrik Dommisch, Corinna Bruckmann, Ines Kapferer-Seebacher, Georg Homuth, Thomas Kocher, Henry Völzke, Klaus Berger, Matthias Laudes, Wolfgang Lieb, Nathalie van der Velde, Natasja van Schoor, Lisette de Groot, Juan Blanco, Angel Carracedo, Raquel Cruz, Astrid Dempfle, Alexander Teumer, Arne S Schaefer, Sandra Freitag-Wolf","doi":"10.1111/jcpe.70195","DOIUrl":"https://doi.org/10.1111/jcpe.70195","url":null,"abstract":"<p><strong>Background and aim: </strong>Genetic susceptibility plays a particularly important role in early-onset (EO) and severe periodontitis (PD). The genetic risk remains largely unexplained because of limited sample sizes and heterogeneous phenotypes in genome-wide association studies (GWAS). This study investigates whether current GWAS data can be used to construct a polygenic score (PGS) capturing genetic susceptibility to severe PD.</p><p><strong>Materials and methods: </strong>A PGS was developed in a three-step design, using a German EO-III/IV-C-PD GWAS (n = 692 cases, ≤ 35 years at diagnosis) as the base dataset, a Spanish EO-III/IV-C-PD GWAS (n = 441 cases) to optimise the score, and as validation a Dutch EO-III/IV-C-PD GWAS (n = 171 cases) and a German population-based GWAS with later-onset III/IV-PD (Studies of Health in Pomerania [SHIP], n = 2941 cases).</p><p><strong>Results: </strong>The PGS showed a trend towards association with disease status in the Spanish sample (Nagelkerke R² = 0.4%, p = 0.06; AUC = 0.52; 95% confidence interval [CI]: 0.49-0.56), but not in the smaller Dutch dataset (R² = 0.2%, p = 0.18; AUC = 0.52; 95% CI: 0.48-0.57) or in the SHIP dataset (AUC = 0.50, 95% CI: 0.48-0.52). Case-control distributions overlapped substantially. Genetic correlation analyses revealed no strong overlap with other associated traits.</p><p><strong>Conclusions: </strong>Current PGS models have limited case-control discriminative ability for PD. Larger harmonised studies are needed to enhance genetic risk prediction and clarify pleiotropic relationships.</p>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":" ","pages":""},"PeriodicalIF":8.3,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Causal Effect of Supra‐ and Sub‐Gingival Instrumentation on the Oral Microbiome of Elderly Periodontitis Patients Treated in Nursing Homes: Secondary Analysis of a Randomised Controlled Trial","authors":"Anna Greta Barbe, Daniel Hagenfeld, Carolin Walther, Dalia Beck, Fedja Farowski, Maria J. G. T. Vehreschild, Sonja H. M. Derman, Sven Kleine Bardenhorst, Dirk Bleiel","doi":"10.1111/jcpe.70193","DOIUrl":"https://doi.org/10.1111/jcpe.70193","url":null,"abstract":"Aims Periodontitis among nursing home residents is increasing as more older adults retain their dentition. Evidence on the impact of periodontal therapy on their oral microbiota is limited. We aimed to assess the effect of outreach‐based supra‐ and sub‐gingival instrumentation on the periodontal microbiome. Materials and Methods In this secondary analysis of an RCT, 36 residents (mean age 85 ± 6 years) with periodontitis had been randomised to supra‐ and sub‐gingival instrumentation (mean duration 14.3 ± 5.2 min) or a 3‐month control. Supragingival and subgingival plaque samples were collected at baseline and 3 months. Bacterial 16S rRNA sequencing and mixed‐effects modelling were used to assess alpha/beta diversity, dysbiosis index and differential abundance between groups over time. Results The intervention group showed clinical improvements, with bleeding on probing decreasing from 45% ± 20% to 35% ± 16% and probing pocket depth decreasing from 4.5 ± 0.5 to 4.0 ± 0.5 mm. Dysbiosis was reduced compared with controls ( <jats:italic>β</jats:italic> = −1.97, <jats:italic>p</jats:italic> = 0.0008). Beta‐diversity confirmed microbial shifts ( <jats:italic>R</jats:italic> <jats:sup>2</jats:sup> = 0.0075, <jats:italic>p</jats:italic> = 0.025), characterised by decreases in differential abundance of <jats:italic>Treponema</jats:italic> and <jats:italic>Fretibacterium</jats:italic> and increases in <jats:italic>Lactobacillus</jats:italic> and <jats:italic>Actinomyces</jats:italic> . Conclusions A pragmatic outreach‐based supra‐ and sub‐gingival instrumentation reduced microbial dysbiosis and improved periodontal parameters in institutionalised older adults, supporting its effectiveness in nursing home care. Trial Registration German Clinical Trials Register (DRKS) registration number: DRKS00029392","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"2 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148767433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to ‘The Effect of Orthodontic Tooth Movement on Intrabony Periodontal Defects After Guided Tissue Regeneration. Part I: Human Histologic Evaluation of 20 Consecutive Cases’","authors":"","doi":"10.1111/jcpe.70178","DOIUrl":"https://doi.org/10.1111/jcpe.70178","url":null,"abstract":"","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"17 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148754434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peri-Implant Soft Tissue Response to Monolithic Zirconia Versus Porcelain-Fused-to-Metal Implant Crowns: Histological and Clinical Outcomes of an RCT","authors":"Yifan Zhang,&nbsp;Sven Mühlemann,&nbsp;Aspasia Pachiou,&nbsp;Stephanie Astrid Stalder,&nbsp;Ronald E. Jung,&nbsp;Ye Lin,&nbsp;Daniel S. Thoma","doi":"10.1111/jcpe.70169","DOIUrl":"10.1111/jcpe.70169","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To assess the peri-implant soft-tissue and hard-tissue response to monolithic zirconia (ZrO&lt;sub&gt;2&lt;/sub&gt;) compared to porcelain-fused-to-metal implant crowns (PFMs).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This report constitutes a pre-specified secondary analysis of this RCT. Eighty-three patients rehabilitated with single-tooth implants in the molar region were originally randomly assigned to receive either a ZrO&lt;sub&gt;2&lt;/sub&gt; or a PFM restoration. At 6 months, clinical parameters (plaque control record, probing depth, bleeding on probing, width of keratinised mucosa and marginal bone level changes) were recorded at the implant site and the adjacent natural tooth. In addition, a peri-implant soft-tissue biopsy specimen was harvested between the implant site and the adjacent tooth. The number of inflammatory cells and fibroblasts/fibrocytes was evaluated within four regions of interest (oral epithelium, sulcular epithelium, junctional epithelium, connective tissue). Descriptive statistics were arrived at for all outcomes, and differences between prosthetic materials, sites and timepoints were analysed using linear mixed-effects models.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The present exploratory secondary analysis included 67 patients (37 ZrO&lt;sub&gt;2&lt;/sub&gt;; 30 PFM) with complete 6-month clinical, radiographic and histological data. Clinical parameters at both implant and adjacent tooth sites remained generally stable from baseline to 6 months, with limited marginal bone level changes and comparable outcomes between groups. Histologically, mixed-effects model analysis showed that the tissue region significantly affected both the inflammatory infiltrate and the fibroblast density (&lt;i&gt;p&lt;/i&gt; &lt; 0.001). The crown materials did not substantially influence the histological outcomes. The distribution of inflammatory infiltrate differed between tooth and implant sites, with the highest values in the sulcular epithelium around implants and in the junctional epithelium around teeth. Fibroblast density was highest in the junctional epithelium at both sites.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Monolithic zirconia and PFM implant-supported single crowns resulted in comparable clinical and radiographic outcomes. The peri-implant soft-tissue response to the two restorative materials showed a greater effect of the tissue region, while the material itself had only negligible effect.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Trial Registration&lt;/","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 9","pages":"1423-1433"},"PeriodicalIF":8.3,"publicationDate":"2026-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70169","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Twenty-Five-Year Follow-Up of Individuals With Intact Periodontium and Differing Susceptibility to Experimentally Induced Gingival Inflammation","authors":"Leonardo Trombelli,&nbsp;Jenny Guidorzi,&nbsp;Dimitris N. Tatakis,&nbsp;Roberto Farina","doi":"10.1111/jcpe.70163","DOIUrl":"10.1111/jcpe.70163","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate the periodontal condition of individuals with different susceptibility to dental biofilm–induced gingivitis 25 years after their classification as high responders (HR) or low responders (LR) to plaque.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Forty-eight systemically and periodontally healthy young adults who participated in a 21-day experimental gingivitis trial in 2000–2001 and exhibited either markedly pronounced (HR, <i>n</i> = 24) or milder (LR, <i>n</i> = 24) gingival inflammation despite similar supragingival plaque exposure were invited to a follow-up visit, during which a periodontal diagnosis was established.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Nine LR and eight HR individuals accepted to participate. Among the LR participants, six (67%) were diagnosed as periodontally healthy or with gingivitis, whereas 100% of HR participants were diagnosed with periodontitis (<i>p</i> = 0.009). Compared to LR, HR individuals presented higher bleeding on probing score (39.5% ± 13.8% vs. 15.0% ± 10.1%; <i>p</i> = 0.003) as well as a higher proportion of visibly inflamed sites (<i>p</i> &lt; 0.001). Intergroup differences could not be explained by other variables, including full-mouth plaque score, oral hygiene habits or adherence to supportive care.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study, based on a very limited sample size and therefore hypothesis-generating rather than confirmatory, suggests that susceptibility to biofilm-induced gingivitis may help identify individuals at different risks of periodontitis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"53 9","pages":"1393-1402"},"PeriodicalIF":8.3,"publicationDate":"2026-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70163","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148498737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}