Journal of Clinical Periodontology最新文献

{"title":"Cognitive and Emotional Peri-Implant Diseases Perception in a Cohort of Periodontitis Patients: A University-Based Cross-Sectional Study","authors":"Isabella De Rubertis,&nbsp;Adriano Fratini,&nbsp;Alice Ferrari,&nbsp;Raffaele Mirra,&nbsp;Nicola Discepoli","doi":"10.1111/jcpe.70011","DOIUrl":"10.1111/jcpe.70011","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aim</h3>\u0000 \u0000 <p>Patients' disease perception plays a fundamental role in adherence to therapy and participation in long-term maintenance programmes. This cross-sectional study aimed to assess the cognitive and emotional representation of peri-implant diseases (PIDs) in a cohort of patients with periodontitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients diagnosed with both periodontitis and PIDs were enrolled. Psychometric evaluation was conducted using the Brief Illness Perception Questionnaire (Brief-IPQ) and the Oral Health Impact Profile-14. Differences were analysed based on disease severity, and a multivariate logistic regression model was applied to explore associations between patient and implant-level variables and illness perception.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 148 patients (459 implants) were included. Patients exhibited low perception of PIDs, with no differences between peri-implant mucositis and peri-implantitis. However, participants with both peri-implantitis and stage III/IV periodontitis presented with significantly higher Brief-IPQ scores. Having ≥ 3 implants and a history of periodontitis treatment were associated with a 4.16-fold and 6.58-fold increase, respectively, in the odds of a higher Brief-IPQ score.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The cognitive and emotional representation of PIDs was found to be low among patients with both periodontitis and PIDs, but appeared to increase in more advanced clinical profiles. A higher number of implants and prior periodontal treatment were associated with greater disease representation.</p>\u0000 \u0000 <p>\u0000 <b>Trial Registration:</b> The study protocol was approved by the University Hospital of Siena Ethics Committee (Siena, Italy) (Sezione Area vasta Toscana Sud Est, no. 25906), and it was registered on Clinicaltrials.gov (registration number: NCT06383351)</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 11","pages":"1573-1583"},"PeriodicalIF":6.8,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Impact of 1-mm Versus 3-mm Definitive Abutments on Marginal Bone Loss and Peri-Implant Disease: A 7-Year Randomised Clinical Trial","authors":"Marta Muñoz,&nbsp;Germán Pardo,&nbsp;Javi Vilarrasa,&nbsp;Álvaro Babiano,&nbsp;Vanessa Ruíz-Magaz,&nbsp;José Nart","doi":"10.1111/jcpe.70009","DOIUrl":"10.1111/jcpe.70009","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate bone level changes in implants with 1-mm- or 3-mm-high abutments over a 7-year period and to investigate the role of abutment height upon peri-implant status.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Two-piece implants were placed 1.5 mm subcrestally with either 1-mm (control) or 3-mm (test) high definitive abutments. Marginal bone level change from the first to seventh year was the primary outcome. Peri-implant status and other patient and peri-implant clinical variables (smoking, peri-implant maintenance therapy compliance, interproximal hygiene, vertical soft tissue thickness and keratinised mucosa width) were also assessed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After 7 years, 37 subjects (63 implants) were analysed: 17 subjects with 32 implants in the 1-mm abutment group, and 20 subjects with 31 implants in the 3-mm abutment group. Significant differences in marginal bone level changes were observed at 7 years. The 3-mm abutment group showed smaller changes compared to the 1-mm abutment group at mesial sites (−0.27 ± 1.32 mm vs. −0.42 ± 0.50 mm, respectively) and distal sites (−0.33 ± 1.39 mm vs. −0.35 ± 0.38 mm), with both differences being statistically significant (<i>p</i> &lt; 0.001). In the control group, 18 implants (54.6%) presented peri-implant mucositis and 6 implants (18.2%) showed peri-implantitis. In the test group, 23 implants (74.2%) presented peri-implant mucositis and 1 implant (3.2%) showed peri-implantitis. No statistically significant differences were found (<i>p</i> = 0.158).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Subcrestally inserted implants with 3-mm definitive abutments experienced minimal bone loss over long-term follow-up compared to 1-mm abutments. However, since the differences were not statistically significant, no conclusions could be drawn on the protective effect against peri-implantitis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 11","pages":"1595-1604"},"PeriodicalIF":6.8,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Microbiota Linking Humoral Response, Periodontitis and Atherosclerosis","authors":"Ramin Akhi,&nbsp;Anton Lavrinienko,&nbsp;Miia Hakula,&nbsp;Rasmus Hindström,&nbsp;Chunguang Wang,&nbsp;Antti Nissinen,&nbsp;Arja M. Kullaa,&nbsp;Tuula Salo,&nbsp;Kari Kaikkonen,&nbsp;Tellervo Tervonen,&nbsp;Pekka Ylöstalo,&nbsp;Janne J. Koskimäki,&nbsp;Sohvi Hörkkö","doi":"10.1111/jcpe.70001","DOIUrl":"10.1111/jcpe.70001","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The humoral immune system is implicated in the link between periodontitis and atherosclerosis. This study aims to explore how interactions between the oral microbiota and humoral immune responses may contribute to this association.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>We analysed data from the Northern Finland Birth Cohort 1966, which included 1560 participants who underwent comprehensive health and oral examinations. Serum antibodies against phosphorylcholine (PCho) and malondialdehyde acetaldehyde (MAA) adducts were measured using chemiluminescence immunoassays. In a sub-cohort (<i>n</i> = 868), the oral microbiome from saliva samples was characterised using 16S rRNA gene sequencing.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Higher serum levels of IgA and IgG to PCho, as well as IgA to MAA, were associated with an increased number of teeth with probing pocket depths (PPD) ≥ 4 mm. Several oral bacterial species, including \u0000 <i>Prevotella dentalis</i>\u0000 , \u0000 <i>Filifactor alocis</i>\u0000 and \u0000 <i>Treponema denticola</i>\u0000 , correlated with both PPD ≥ 4 mm and IgA/IgG responses to PCho. Mediation analysis, adjusted for periodontitis risk factors, identified <i>F. alocis</i> as a mediator linking elevated plasma IgG to PCho with the number of teeth with PPD ≥ 4 mm. Additionally, individuals harbouring <i>F. alocis</i> exhibited increased carotid intima-media thickness.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our findings suggest that <i>F. alocis</i> may serve as a microbial link between periodontitis and atherosclerosis. Future mechanistic studies should investigate how <i>F. alocis</i> induces systemic IgG responses and contributes to atherosclerosis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 11","pages":"1550-1559"},"PeriodicalIF":6.8,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Impact of Non-Impacted Third Molar Extraction on Non-Surgical Periodontal Therapy for Adjacent Second Molars: A Prospective Split-Mouth Study","authors":"Rui Gao,&nbsp;Hong-Lei Qu,&nbsp;Yi Tian,&nbsp;Li-Juan Sun,&nbsp;Xiao-Tao He,&nbsp;Bei-Min Tian,&nbsp;Yuan Yin,&nbsp;Fa-Ming Chen,&nbsp;Rui-Xin Wu","doi":"10.1111/jcpe.70010","DOIUrl":"10.1111/jcpe.70010","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To compare the outcomes of non-surgical periodontal therapy (NSPT) alone and NSPT plus adjacent non-impacted third molar (N-M3) removal on second molars (M2s).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>In this prospective split-mouth study, 40 patients with periodontitis who had N-M3s on both sides of the same jaw were enrolled. For each patient, a full-mouth NSPT was performed, with one N-M3 extracted (N-M3−) and the other N-M3 retained (N-M3+). Periodontal clinical parameters, gingival crevicular fluid (GCF) and subgingival plaque samples were measured/collected before (T0), 3 months after (T1) and 6 months after (T2) the treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>All M2s showed improved probing depth after treatment. At T1 and T2, M2s in the N-M3− group yielded better outcomes in periodontal clinical parameters than the N-M3+ group, along with a significant decrease in the abundance of periodontal pathogens such as \u0000 <i>Porphyromonas gingivalis</i>\u0000 , \u0000 <i>Prevotella nigrescens</i>\u0000 and \u0000 <i>Fusobacterium nucleatum</i>\u0000 in subgingival plaque. At T2, the M2s in the N-M3− group had significantly lower GCF volume and higher interleukin-10 levels than those in the N-M3+ group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Over the 6-month observation period, removal of adjacent N-M3s enhanced the outcome of NSPT for second molars, as demonstrated clinically, immunologically and microbiologically.</p>\u0000 \u0000 <p>\u0000 <b>Trial Registration:</b> Chinese Clinical Trail Registry (identification number: ChiCTR2300070343). https://www.chictr.org.cn/showproj.html?proj=194830 Date of Registration: April 10th, 2023</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 11","pages":"1616-1625"},"PeriodicalIF":6.8,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144819825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Accuracy of Self-Reported Questionnaires for Detecting Periodontitis Across Multiple Cultures and Geographic Locations: A Systematic Review and Meta-Analysis","authors":"Mengning Bi,&nbsp;Yu Xie,&nbsp;Xiaoyu Yu,&nbsp;Hairui Li,&nbsp;Yuan Li,&nbsp;Maurizio S. Tonetti","doi":"10.1111/jcpe.70002","DOIUrl":"10.1111/jcpe.70002","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate self-reported questionnaires' intrinsic validity and diagnostic accuracy for detecting periodontitis across diverse cultural and geographic contexts.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Electronic searches were conducted in PubMed, Embase and the Cochrane Library until 4 March 2025. Studies included those using the Centers for Disease Control and Prevention and the American Academy of Periodontology (CDC/AAP) criteria or the 2017 World Workshop classifications as reference standards and reporting the diagnostic accuracy of self-reported questionnaire items. The validity of the eight-item questionnaire developed by the CDC/AAP was assessed by analysing the proportion of answers, and bias was evaluated using the QUADAS-2 tool. Owing to the limited number of studies using the 2017 World Workshop classifications, the quantitative synthesis was restricted to those using the CDC/AAP criteria. Sensitivity, specificity, diagnostic odds ratio (DOR) and 95% confidence intervals (CIs) were calculated for total periodontitis (including mild, moderate and severe cases), moderate-to-severe periodontitis and severe periodontitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Totally, 23 studies (from 22 articles) were included in the systematic review, with 16 studies (from 15 articles) eligible for meta-analysis. The ‘Don't know/Refused’ option across the eight items of the CDC/AAP questionnaire ranged from 0% to 46.1%, indicating variable comprehension of certain items. Pooled sensitivity and specificity across the questionnaire items ranged from 17% to 82% and from 23% to 97%, respectively. DOR varied from 0.75 (95% CI: 0.54–1.03) to 8.01 (95% CI: 2.33–27.45). Significant heterogeneity was observed for most questions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Self-reported questionnaires show potential for monitoring periodontitis but face issues with sensitivity and cross-cultural validity. Future research should focus on culturally adaptive designs and standardised validation protocols to enhance diagnostic accuracy and improve their effectiveness in global periodontal health screening.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 11","pages":"1510-1528"},"PeriodicalIF":6.8,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144802604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Early Re-Entry Surgery Following Simultaneous Guided Bone Regeneration Compromise the Dimension of Peri-Implant Tissues?","authors":"Sung Jin Yoo,&nbsp;Jin-Young Park,&nbsp;Young Woo Song,&nbsp;Ui-Won Jung,&nbsp;Daniel S. Thoma,&nbsp;Ronald E. Jung","doi":"10.1111/jcpe.70006","DOIUrl":"10.1111/jcpe.70006","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To investigate whether early re-entry surgery following simultaneous guided bone regeneration (GBR) and implant placement has a negative impact on the outcome of bone regeneration and osseointegration.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>In the edentulous mandible of six mongrel dogs, buccal peri-implant dehiscence defects were surgically created. Bone-level implants were placed with GBR, followed by submerged healing. Two experimental groups were randomly assigned according to the timing of re-entry and healing abutment connection at 2 months (early group) and 4 months (late group) following GBR. All animals were euthanised 5 months after GBR for histological analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>One implant in the late group failed as a result of fibrin incarceration. There was no statistically significant difference between the two groups regarding new bone area (1.98 mm² [interquartile range, 1.53–2.98] and 0.88 mm² [0.09–1.79]; early vs. late group, respectively; <i>p</i> = 0.063); bone-to-implant contact (53.80% [40.88–63.10] and 54.15% [45.21–66.02], early vs. late groups, respectively; <i>p</i> &gt; 0.999); width and height of the augmented tissue (<i>p</i> &gt; 0.05); and peri-implant mucosal dimensions including thickness, height and volume (<i>p</i> &gt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Early second-stage surgery results in similar bone regeneration, osseointegration and mucosal dimensions as late abutment connection.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 11","pages":"1639-1647"},"PeriodicalIF":6.8,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144797104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontitis and Periodontal Conditions in Systemically Healthy Children and Adolescents.","authors":"Inbar Eshkol-Yogev,Nagore Ambrosio,Cheryl Somani,Elena Figuero,Lior Shapira,Janet Davies","doi":"10.1111/jcpe.14199","DOIUrl":"https://doi.org/10.1111/jcpe.14199","url":null,"abstract":"OBJECTIVETo answer the PICoS question 'in systemically healthy children and adolescents (Population), what are the main features of periodontitis, necrotising periodontal diseases (NPD) and other periodontal conditions (periodontal abscesses, endo-periodontal lesions, traumatic occlusal forces, prosthesis- and tooth-related factors) (Phenomenon of Interest) in terms of epidemiology, aetiology, risk factors/indicators, diagnosis, prevention or therapy (Context)'.MATERIALS AND METHODSFour databases were searched up to September 2024, and studies were included that considered children and adolescents (< 18 years).RESULTSDuring the search, 5389 potential publications were identified of which 205 articles were included. Most studies reported on periodontitis (n = 148), followed by mucogingival conditions (n = 42), NPD (n = 13) and periodontal abscesses (n = 2). There were no studies dealing with other periodontal conditions.CONCLUSIONSIn children and adolescents (1) the quality of the evidence is generally very low; (2) prevalence of periodontitis varied from 0.1% to 30.36%, and increases over time, with variations due to diagnostic criteria, risk indicators and study populations; (3) NPD showed large variability in prevalence (0%-27.1%) associated with socioeconomic, nutritional and environmental factors and (4) prevalence of gingival recession ranged from 1% to 74%, orthodontic therapy being one of the most studied associated factors.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"30 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144792118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dimensional Changes After Different Alveolar Ridge Preservation Techniques for Posterior Region: A Randomised Controlled Clinical Trial","authors":"Leticia Sandoli Arroteia,&nbsp;Matheus Paschoaletto Lopes,&nbsp;Marcela Tarosso Réa,&nbsp;Thalita R. Vieira e Oliveira,&nbsp;Matheus L. Oliveira,&nbsp;Marcelo de Faveri,&nbsp;Mauro Pedrine Santamaria,&nbsp;Lucas Araujo Queiroz,&nbsp;Marcio Zaffalon Casati,&nbsp;Renato Corrêa Viana Casarin","doi":"10.1111/jcpe.70004","DOIUrl":"10.1111/jcpe.70004","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Alveolar ridge preservation (ARP) after tooth extraction aims to maintain ridge dimensions for future implant placement. However, limited evidence is available for posterior sites. We evaluated the dimensional changes in posterior extraction sockets using four approaches: modified free gingival graft (MFGG); MFGG with xenograft (MFGG + XG); guided bone regeneration with titanium membrane and xenograft (TM + XG); and unassisted socket healing (USH).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Patients requiring posterior tooth extraction were randomly assigned to one of four groups (<i>n</i> = 22/group). Cone-beam computed tomography (CBCT) was performed immediately after operation and at 6 months to assess vertical and horizontal alveolar ridge changes and implant-related outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Significant dimensional changes occurred in all groups (<i>p</i> &lt; 0.05). The TM + XG and MFGG + XG groups showed better preservation of vertical ridge dimensions than the USH and MFGG groups (<i>p</i> &lt; 0.05). Horizontal reductions were significant in all groups (<i>p</i> &lt; 0.05). USH presented the highest sinus floor elevation rate (67% of maxillary cases) and the most frequent use of short implants (&lt; 8.5 mm; 71%). Postoperative pain was significantly greater in the MFGG groups compared to the USH group (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Bone grafting with MFGG or a titanium membrane enhanced ridge preservation and reduced the need for additional surgery compared to USH.</p>\u0000 \u0000 <p>\u0000 <b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT06081296</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 11","pages":"1584-1594"},"PeriodicalIF":6.8,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144778147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative Stress and Gut Microbiota Interplay Exacerbates Periodontitis in Diabetic Mice","authors":"Haotian Gong,&nbsp;Linyue Zhang,&nbsp;Yangbo Liu,&nbsp;Xulei Yuan,&nbsp;Yuanyuan Liu,&nbsp;Jiawei Tang,&nbsp;Mengjiao Zhou,&nbsp;Jinlin Song,&nbsp;Tingwei Zhang","doi":"10.1111/jcpe.70003","DOIUrl":"10.1111/jcpe.70003","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To investigate the interplay between oxidative stress and gut microbiota in the pathogenesis of increased periodontitis in diabetic mice and explore potential therapeutic strategies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Diabetic periodontitis (DP) mouse models were established and subjected to interventions including antioxidant treatment, co-housing experiments and faecal microbiota transplantation (FMT). Alveolar bone loss, periodontal inflammation, oxidative stress markers, gut microbiota composition and intestinal barrier function were evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Diabetes exacerbated alveolar bone loss and inflammation markers in mice with periodontitis. DP mice exhibited significantly elevated systemic oxidative stress and gut dysbiosis compared to controls. Curcumin treatment effectively improved these parameters. Co-housing experiments between curcumin-treated and untreated DP mice showed that beneficial gut microbiota could be transferred between cage mates, leading to improved periodontal outcomes in untreated mice. Additionally, FMT from healthy donors reduced alveolar bone loss and periodontal inflammatory markers while improving oxidative stress parameters and restoring gut microbiota balance and barrier function.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study demonstrates that the interaction between oxidative stress and gut dysbiosis may form a pathogenic loop associated with the exacerbation of periodontitis in diabetic conditions. The successful outcomes of antioxidant treatment and FMT suggest multiple adjunctive therapeutic approaches for managing DP.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 11","pages":"1626-1638"},"PeriodicalIF":6.8,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144777842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association of Periodontal Inflammation and Systemic Health Indicators: A Machine Learning Approach","authors":"Yumeng Yan,&nbsp;Praveen Sharma,&nbsp;Jeanie Suvan,&nbsp;Francesco D'Aiuto","doi":"10.1111/jcpe.70000","DOIUrl":"10.1111/jcpe.70000","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The relationship between oral and systemic inflammation has profound implications for understanding the broader health impacts of periodontitis. The aim of this study was to (a) explore the association between periodontal inflammation and markers of systemic inflammation and metabolic health, and (b) preliminarily assess periodontal status based on systemic health indicators using machine learning techniques.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data from a cross-sectional cohort (<i>N</i> = 667) were modelled (simple/multiple linear, fractional polynomial, logistic and random forest regression) to examine the association between systemic and periodontal measures. Three classifiers—random forest (RF), support vector machine (SVM) and gradient boosting (GB)—were used using periodontal inflamed surface area (PISA) and demographic and anthropometric variables (age, gender, ethnicity, body mass index [BMI] and smoking habits) as inputs to predict systemic inflammation (defined using serum C-reactive protein [CRP] levels). The best performing classification models (evaluated using area under the curve, AUC analyses) were validated using a second nationally representative dataset from the National Health and Nutrition Examination Surveys (NHANES) 2001–2002 and 2003–2004 combined datasets (<i>N</i> = 2288). Next, RF, SVM and GB were employed incorporating a set of systemic parameters (including serum CRP and lipid profiles) to predict the diagnosis of periodontitis. The best performing classification models were then validated using the NHANES 2009–2010 (<i>N</i> = 664) dataset.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A nonlinear trend of CRP levels and PISA was confirmed by fractional polynomial regression (<i>p</i> = 0.008). Further, multiple linear regression analyses (adjusted for age, gender, ethnicity, BMI and smoking habits) confirmed a statistically significant relationship between log-transformed CRP levels and PISA (<i>p</i> &lt; 0.0001). Logistic regression confirmed a relationship between PISA and low-density lipoprotein (LDL) in both crude and adjusted models. Among the classification models, SVM showed the highest performance in distinguishing CRP &lt; 2 mg/L from CRP ≥ 2 mg/L (AUC = 0.71). The SVM model was successfully replicated in the NHANES 2001–2002 and 2003–2004 waves (AUC = 0.74). Prediction of periodontitis status (case vs. control) based on systemic indicators using the SVM model achieved the best performance with a mean AUC of 0.82. This was partially confirmed after external validation using the 2009–2010 NHANES dataset (AUC of 0.72).</p>\u0000 </section>\u0000 \u0000 ","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 10","pages":"1466-1477"},"PeriodicalIF":6.8,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.70000","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}