Association of Periodontal Condition With Serum C‐Reactive Protein Levels: The Role of Serum Apolipoproteins' Concentration

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology Pub Date : 2025-07-10 DOI:10.1111/jcpe.14202

Anniina Haro, Tuomas Saxlin, Anna Liisa Suominen, Antti Jula, Pekka Ylöstalo

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Abstract

AimTo investigate whether the systemic inflammatory response against inflammatory conditions in the periodontium is related to serum apolipoprotein B (ApoB) and A1 (ApoA1) concentrations.Material and MethodsThe study consisted of the Health 2000 Survey participants (n = 2709) aged 30–49 years. The inflammatory condition of the periodontium was assessed by means of the number of teeth with deepened (≥ 4 mm) and deep (≥ 6 mm) periodontal pockets. Systemic inflammation was measured by serum C‐reactive protein (CRP) levels. The role of ApoB and ApoA1 was studied by performing regression analyses and stratified analyses (according to the median values).ResultsIn logistic regression analyses, the number of teeth with deepened (≥ 4 mm) periodontal pockets was associated with serum CRP levels among those participants whose serum ApoB concentration was ≥ 1.12 g/L. When the participants' ApoB concentration was < 1.12 g/L, such an association between deepened periodontal pockets and CRP was not observed. The direction or strength of the association between periodontal pockets and CRP was not essentially different in the ApoA1 strata.ConclusionSystemic response against poor periodontal condition varied between individuals. The variation appeared to be related more to the serum concentration of ApoB than ApoA1.

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牙周状况与血清C反应蛋白水平的关系：血清载脂蛋白浓度的作用

目的探讨血清载脂蛋白B （ApoB）和A1 （ApoA1）浓度是否与牙周组织炎症反应有关。材料与方法本研究纳入健康2000调查参与者（n = 2709），年龄30-49岁。通过深度（≥4mm）和深度（≥6mm）牙周袋的牙数来评估牙周组织的炎症情况。通过血清C反应蛋白（CRP）水平检测全身性炎症。通过回归分析和分层分析（按中位数）研究ApoB和ApoA1的作用。结果经logistic回归分析，血清载脂蛋白（ApoB）浓度≥1.12 g/L的受试者牙周袋深度（≥4 mm）牙数与血清CRP水平相关。当参与者的ApoB浓度为<；1.12 g/L时，未观察到牙周袋加深与CRP之间的相关性。在ApoA1层中，牙周袋与CRP之间的关联方向或强度并无本质差异。结论不同个体对牙周不良的全身反应存在差异。这种变异似乎与血清ApoB浓度比ApoA1浓度更相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Periodontology 医学-牙科与口腔外科

CiteScore

13.30

自引率

10.40%

发文量

175

审稿时长

3-8 weeks

期刊介绍： Journal of Clinical Periodontology was founded by the British, Dutch, French, German, Scandinavian, and Swiss Societies of Periodontology. The aim of the Journal of Clinical Periodontology is to provide the platform for exchange of scientific and clinical progress in the field of Periodontology and allied disciplines, and to do so at the highest possible level. The Journal also aims to facilitate the application of new scientific knowledge to the daily practice of the concerned disciplines and addresses both practicing clinicians and academics. The Journal is the official publication of the European Federation of Periodontology but wishes to retain its international scope. The Journal publishes original contributions of high scientific merit in the fields of periodontology and implant dentistry. Its scope encompasses the physiology and pathology of the periodontium, the tissue integration of dental implants, the biology and the modulation of periodontal and alveolar bone healing and regeneration, diagnosis, epidemiology, prevention and therapy of periodontal disease, the clinical aspects of tooth replacement with dental implants, and the comprehensive rehabilitation of the periodontal patient. Review articles by experts on new developments in basic and applied periodontal science and associated dental disciplines, advances in periodontal or implant techniques and procedures, and case reports which illustrate important new information are also welcome.