Journal of Clinical Periodontology最新文献

{"title":"Long-Term Prognosis of Teeth With Class II Furcation Involvement: A Retrospective Cohort Study","authors":"P. Eickholz,&nbsp;T. Cordis,&nbsp;B. Dannewitz,&nbsp;B. Pretzl,&nbsp;M. Schröder,&nbsp;N. Lingwal,&nbsp;N. El Sayed","doi":"10.1111/jcpe.14186","DOIUrl":"10.1111/jcpe.14186","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate the survival of teeth with class II furcation involvement (FI) ≥ 5 years after active periodontal treatment (APT) and to identify the prognostic factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>All charts of patients having undergone APT at the Department of Periodontology of Goethe-University Frankfurt, Germany, were screened for teeth with class II FI. APT had to be accomplished ≥ 5 years ago. Charts were analysed for data of class II FI teeth at baseline (T0), after APT (T1) and at the last supportive periodontal care (SPC/T2).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Two-hundred and twenty-two patients (age: 56.5 ± 10.1 years; 118 females; 35 active smokers; 17 diabetics, 154 stage III, 68 stage IV, 94 grade B, 128 grade C) presented 543 teeth with class II FI. Sixty-one patients lost 93 teeth (17%), on average, over 108.4 ± 36.5 months of SPC. Logistic/Cox proportional hazards mixed-model regressions associated increased tooth loss with irregular SPC (<i>p</i> = 0.023/0.073), premolar versus molar (<i>p</i> = 0.041/0.017), root canal filling (RCF) (<i>p</i> &lt; 0.001) and multiple class II FI per tooth at T1 (<i>p</i> = 0.001/0.024).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Of a total of 543 teeth with class II FI, 83% were retained for 108.6 ± 36.5 months. Multiple class II FI at T1, RCF, premolars and irregular SPC were found to compromise the long-term prognosis of teeth with class II FI.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 9","pages":"1298-1305"},"PeriodicalIF":6.8,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14186","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Operative Times, Costs and Patient-Related Outcome Measures in Vertical Ridge Augmentation With Customised Reinforced PTFE Mesh Versus CAD/CAM Titanium Mesh: Secondary Analysis of a Randomised Clinical Trial","authors":"Alessandro Cucchi,&nbsp;Sofia Bettini,&nbsp;Lucia Tedeschi,&nbsp;Debora Franceschi,&nbsp;Istvan Urban,&nbsp;Antonino Fiorino,&nbsp;Giuseppe Corinaldesi","doi":"10.1111/jcpe.14185","DOIUrl":"10.1111/jcpe.14185","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This secondary analysis of a randomised clinical trial aimed to investigate vertical ridge augmentation (VRA) by comparing complication rates (primary outcome), times, costs and patient-reported outcome measures (PROMs) between customised Ti-reinforced PTFE mesh and customised CAD/CAM titanium mesh.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Patients with vertical bone defects were randomly assigned to alveolar bone augmentation using either Ti-PTFE mesh or Ti mesh (T0). After 6–9 months, barriers were removed, and computer-guided surgery was performed to place implants in the augmented sites (T1). Complications, times, costs and PROMs (anxiety, pain, anti-inflammatory drug dosage, limitations in daily functions) were assessed and analysed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Forty-eight of 50 patients completed the bone augmentation surgery as per protocol. The estimated difference in healing complications was −0.04% (CI: −0.22 to 0.13), confirming the non-inferiority of Ti meshes to PTFE meshes. The estimated differences were −3.50 min (CI: −23.49 to 16.49) for total operative time (<i>p</i> = 0.688); €17.37 (−77.25 to 111.99) for costs (<i>p</i> = 0.130); −0.17 (CI: −0.80 to 0.47) for anti-inflammatory drug usage (<i>p</i> = 0.299); 0.56 (CI: −1.97 to 0.85) for pain levels (<i>p</i> = 0.565); and −0.13 (CI: −0.61 to 0.36) for limitations in daily functions (<i>p</i> = 0.528), on the day after surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Outcomes were favourable, which encourage the use of both medical devices with low complication rates and both digital approaches, resulting in favourable operative times and PROMs.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 7","pages":"971-982"},"PeriodicalIF":5.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14185","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial Markers for Diagnosis and Risk Assessment for Periodontal Diseases: A Systematic Literature Search and Narrative Synthesis","authors":"Nagihan Bostanci,&nbsp;Daniel Manoil,&nbsp;Wannes Van Holm,&nbsp;Georgios N. Belibasakis,&nbsp;Wim Teughels","doi":"10.1111/jcpe.14183","DOIUrl":"10.1111/jcpe.14183","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To examine the accuracy of microbiological biomarkers in diagnosing periodontal diseases, specifically addressing three focus questions: (FQ1) distinguishing health from disease; (FQ2) predicting disease progression; and (FQ3) assessing treatment outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A PRISMA-guided search in MEDLINE, EMBAS and WEB OF SCIENCE included cross-sectional and longitudinal studies (e.g., randomised controlled trials, cohort studies) with ≥ 20 participants per group. Eligible studies involved individuals diagnosed with periodontal health, gingivitis or periodontitis, based on well-defined clinical criteria, and utilised microbiological analyses of oral fluids and/or dental plaque. Diagnostic accuracy had to be evaluated using sensitivity, specificity or area under the receiver operating characteristic (ROC) curve (AUC), or alternatively, data for their computation had to be provided.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Thirty-one studies were included, mostly cross-sectional or case–control, with significant variability in sampling sites, microbial analyses and diagnostic definitions, complicating direct comparisons. Frequently investigated biomarkers included \u0000 <i>Aggregatibacter actinomycetemcomitans</i>\u0000 (JP2 genotype), \u0000 <i>Porphyromonas gingivalis</i>\u0000 , \u0000 <i>Tannerella forsythia</i>\u0000 and \u0000 <i>Treponema denticola</i>\u0000 . The highest diagnostic accuracy (AUC &gt; 0.95) was achieved through composite microbiome-based metrics such as the subgingival microbial dysbiosis index. However, methodological heterogeneity and inconsistent criteria limited reliability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Although microbiological biomarkers hold promise for periodontal disease diagnostics and monitoring, current evidence is insufficient for clinical implementation. Future research should standardise methodologies, sampling protocols and diagnostic criteria to ensure robust validation and facilitate integration into precision dentistry.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 S29","pages":"125-154"},"PeriodicalIF":5.8,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14183","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosomes Derived From Human Gingival Mesenchymal Stem Cells Induce Metabolic Reprogramming of Inflammatory Macrophages","authors":"Jialu Wang,&nbsp;Yingzhe Hu,&nbsp;Zhiguo Wang,&nbsp;Chun Fan,&nbsp;Ye Liu,&nbsp;Yutong Xie,&nbsp;Lubin Liu,&nbsp;Jingshu Yang,&nbsp;Quanchen Xu","doi":"10.1111/jcpe.14184","DOIUrl":"10.1111/jcpe.14184","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To investigate the influence and mechanism of exosomes derived from human gingival mesenchymal stem cells (GMSC-Exo) regulating macrophage polarisation through metabolic reprogramming.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Human acute monocytic leukaemia cells (THP-1)-derived macrophages were treated with GMSC-Exo or \u0000 <i>Porphyromonas gingivalis</i>\u0000 lipopolysaccharide (<i>P.g</i>-LPS) in vitro. Metabolic inhibitors were used to study the role of metabolic reprogramming in GMSC-Exo-induced polarisation, while the hypoxia-inducible factor-1 alpha (HIF-1α) modulators were employed to explore the HIF-1α signalling pathway's impact on macrophage metabolic reprogramming. The impact of GMSC-Exo on periodontitis and macrophage metabolism was assessed using a rat model in vivo.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In vitro experiments confirmed that GMSC-Exo promoted the polarisation of macrophages from pro-inflammatory M1 type (classically activated) to anti-inflammatory M2 type (alternatively activated) by promoting metabolic reprogramming (glycolysis to oxidative phosphorylation). In this process, the activation of the HIF-1α signalling pathway was inhibited. In vivo experiments revealed that GMSC-Exo could regulate the inflammatory microenvironment of periodontal tissue and the metabolic pattern of macrophages.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>By inhibiting the activation of HIF-1α signalling pathway, GMSC-Exo trigger metabolic reprogramming in macrophages, thereby regulating the macrophage transformation from pro-inflammatory M1 phenotype to anti-inflammatory M2 phenotype. This change enhances the local inflammatory environment, aiding tissue repair and regeneration.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 8","pages":"1196-1210"},"PeriodicalIF":5.8,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential Response to Non-Surgical Periodontal Therapy Between Intrabony and Suprabony Defects: A Retrospective Analysis","authors":"Alessandro Cuozzo,&nbsp;Mishika Arora,&nbsp;Lorenzo Marini,&nbsp;Joshua Hurley,&nbsp;Zainab Malaki,&nbsp;Jing Kang,&nbsp;Luca Ramaglia,&nbsp;Luigi Nibali","doi":"10.1111/jcpe.14181","DOIUrl":"10.1111/jcpe.14181","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To assess the clinical response to Non-Surgical Periodontal Therapy (NSPT) between suprabony and intrabony defects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Totally 200 NSPT patients' records from the King's College London—Oral, Dental and Craniofacial Biobank were included. Periapical radiographs of sites with Periodontal Probing Depth (PPD) &gt; 4 mm were assessed. Changes in periodontal measurements between baseline and three-month re-evaluation were examined and compared across suprabony and intrabony sites. Multilevel analysis was carried out to assess the relative contribution of site-, tooth-, patient- and treatment-related factors on the clinical outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Although intrabony defects showed higher PPD reduction after NSPT compared with suprabony defects, this was a function of initial deeper PPD. In fact, suprabony defects outperformed intrabony defects for ‘pocket closure’ at every initial PPD threshold and overall were 2.60 times more likely to achieve ‘pocket closure’. Defect morphology was one of several factors affecting treatment outcomes. The relative contribution to ‘pocket closure’ was 64.9% for site-, 26.1% for patient-, 9.0% for tooth- and 1% for treatment-related factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Bone defect morphology influences clinical outcome of NSPT, with suprabony defects being twice as likely to achieve pocket closure and resulting in 0.6 mm more PPD reduction compared with intrabony defects.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 8","pages":"1158-1166"},"PeriodicalIF":5.8,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14181","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144097742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Randomized Controlled Study on the Treatment of Isolated Interdental Intrabony Defects Using the Modified Minimally Invasive Surgical Technique With or Without a Collagen-Enriched Bovine-Derived Xenograft: A 2-Year Analysis","authors":"Yuzhe Sun,&nbsp;Haidong Zhang,&nbsp;Churen Zhang,&nbsp;Xiaochi Chang,&nbsp;Hongqiao Zhao,&nbsp;Xiangyu Sun,&nbsp;Pierpaolo Cortellini,&nbsp;Kaining Liu,&nbsp;Jianxia Hou","doi":"10.1111/jcpe.14178","DOIUrl":"10.1111/jcpe.14178","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aimed to evaluate the efficacy of the modified minimally invasive surgical technique (M-MIST) combined with a collagen-enriched bovine-derived xenograft (CEBDX) for the treatment of isolated interdental intrabony defects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This is a randomized controlled trial including 40 isolated interdental intrabony defects in 40 patients. The test group received M-MIST and CEBDX, and the control group received M-MIST alone. Re-evaluations were performed 1 and 2 years after surgery, with probing depth (PD) and clinical attachment level (CAL) measured at the buccal/labial and lingual/palatal sides of the defects as at baseline. Periapical radiographs and CBCT were also performed to evaluate the radiographic bone changes of the defects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Thirty-eight defects were evaluated at the 1- and 2-year follow-ups, and both groups showed statistically significant improvements in PD, CAL and radiographic bone volume. The test group exhibited increased PD reduction (3.95 ± 1.39 mm vs. 2.95 ± 1.51 mm, <i>p</i> = 0.041) and CAL gain (3.58 vs. 2.53 mm on average, <i>p</i> = 0.043) at the buccal side of the defects. No difference was found at the lingual side. A significantly greater radiographic bone volume gain (17.77 ± 11.44 mm³ vs. 8.63 ± 7.10 mm³, <i>p</i> = 0.011) was found in the test group at the 2-year follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>M-MIST was effective both alone and with CEBDX. The addition of CEBDX significantly improved radiographic bone volume gain and PD reduction, and CAL gain at the buccal side of the defects.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 8","pages":"1147-1157"},"PeriodicalIF":5.8,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increasing Serum Vitamin D Levels Reduces Gingival Crevicular Fluid Matrix Metalloproteinase-9 Levels in Periodontal Health and Diseases","authors":"Vusal Gurbanov,&nbsp;Ayla Öztürk,&nbsp;Fatma Doğruel,&nbsp;Hatice Saraçoğlu,&nbsp;Cevat Yazıcı","doi":"10.1111/jcpe.14175","DOIUrl":"10.1111/jcpe.14175","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To investigate whether restoring serum vitamin D levels in a population requiring supplementation affects matrix metalloproteinase-9 (MMP-9) levels in the gingival crevicular fluid (GCF) of individuals with periodontal health, gingivitis and periodontitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This prospective cohort study enrolled 101 participants with vitamin D deficiency, including those with periodontitis (34) and gingivitis (34) and healthy individuals (33). The periodontal status was evaluated using radiographic and clinical assessments of probing depth, clinical attachment loss, gingival index and plaque index. The analysis of MMP-9 levels in the GCF collected from the same dental sites was performed at baseline and 1 month post supplementation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After 1 month of vitamin D supplementation, a significant decrease in GCF MMP-9 levels was observed across all groups, with the most notable reduction observed in the periodontitis group. The healthy group exhibited the highest percentage reduction at 47%. Linear regression analysis confirmed that changes in vitamin D levels and pocket depth influenced MMP-9 alterations in the GCF.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Restoration of vitamin D levels in vitamin D-deficient patients to the recommended average level (30 ng/mL), according to established guidelines, led to decreased MMP-9 levels in individuals with different periodontal statuses (healthy, gingivitis or periodontitis), potentially mitigating periodontal risks.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 8","pages":"1115-1124"},"PeriodicalIF":5.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14175","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Radiological Markers of Periodontal Status and Risk of Cognitive Decline and Incident Dementia","authors":"Sam Asher,&nbsp;Anna Liisa Suominen,&nbsp;Ruth Stephen,&nbsp;Tiia Ngandu,&nbsp;Seppo Koskinen,&nbsp;Alina Solomon","doi":"10.1111/jcpe.14173","DOIUrl":"10.1111/jcpe.14173","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>There is evidence linking tooth loss with dementia; however, similar findings for periodontitis are inconclusive.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>We conducted cross-sectional (<i>N</i> = 4046) and longitudinal analyses (<i>N</i> = 2769) on data from the Health 2000 and 2011 surveys for establishing any associations of periodontal health with baseline cognition, 11-year risk of cognitive decline and 15-year risk of incident dementia (<i>N</i> = 4073; study period from 1 September 2000 to 31 December 2015). Periodontal health was assessed via multiple clinical and radiographic markers. Based on periodontal pocket depths (PPDs), we defined periodontitis as moderate or severe. Cognitive tests at baseline and follow-up were administered, and dementia diagnoses until 2015 were retrieved from health registers. Analyses included logistic and Cox proportional regression, accounting for reverse causality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Cross-sectionally, moderate periodontitis was associated with lower overall cognition (OR = 1.19:1.02–1.40), verbal fluency (OR = 1.16:1.00–1.35) and immediate recall (OR = 1.22:1.04–1.42); PPD with lower overall cognition (OR = 1.22:1.04–1.43) and verbal fluency (OR = 1.18:1.02–1.38); and bleeding on probing (BOP) with verbal fluency (OR = 1.26:1.07–1.48) and immediate recall (OR = 1.22:1.02–1.45). Longitudinally, moderate periodontitis was associated with the risk of decline in immediate recall (OR = 1.29:1.04–1.60) and severe periodontitis with verbal fluency (OR = 1.46:1.01–2.11); PPD with immediate recall (OR = 1.23:1.00–1.53); and BOP with verbal fluency (OR = 1.31:1.05–1.63). Edentulism was associated with multiple cognitive tests (OR range:1.71–1.88). No associations with the risk of incident dementia were observed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Poor periodontal health may increase the risk of cognitive decline. Future studies into the underlying mechanisms are warranted.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 8","pages":"1082-1098"},"PeriodicalIF":5.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14173","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"E-Poster | Research Presentation","authors":"","doi":"10.1111/jcpe.14160","DOIUrl":"https://doi.org/10.1111/jcpe.14160","url":null,"abstract":"","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 S28","pages":"162-377"},"PeriodicalIF":5.8,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143939479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EuroPerio11 Author Index","authors":"","doi":"10.1111/jcpe.14163","DOIUrl":"https://doi.org/10.1111/jcpe.14163","url":null,"abstract":"","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 S28","pages":"581-608"},"PeriodicalIF":5.8,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143939481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}