Glomerular Haematopoietic Prostaglandin D Synthase-Prostaglandin D2 Axis Contributes to the Periodontitis-Related Exacerbation of Diabetic Nephropathy in KK-Ay Mice.
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引用次数: 0
Abstract
Aims: Recent clinical studies have proposed a potential association between chronic kidney diseases, including diabetic nephropathy (DN) and periodontitis. Nevertheless, the causal relationship of periodontitis with DN and the underlying molecular mechanisms remain unclear.
Materials and methods: Ligature-induced experimental periodontitis (LIP) was induced in KK-Ay mice to investigate the molecular mechanisms underlying the LIP-mediated aggravation of glomerular pathology in DN. Outpatients with type 2 diabetes (T2D) at Kyushu University Hospital were recruited to confirm the association of renal dysfunction and periodontitis with a urinary factor identified by RNA sequencing (RNA-seq) in the mouse glomeruli.
Results: LIP aggravated renal dysfunction and glomerular pathologies in KK-Ay mice. RNA-seq in the glomeruli revealed haematopoietic prostaglandin D synthase (HPGDS) as the possible factor bridging periodontitis with DN progression. Glomerular PGD2 levels in KK-Ay mice were significantly elevated by LIP. Oral administration of an HPGDS inhibitor, HQL-79, successfully prevented LIP-mediated DN progression in KK-Ay mice by lowering glomerular PGD2 levels. Urinary HPGDS-to-creatinine ratio could be associated with renal dysfunction and periodontitis in outpatients with T2D.
Conclusion: Periodontitis may contribute to DN progression via the glomerular HPGDS-PGD2 axis. These results suggest a novel mechanism in periodontitis-related DN progression.
期刊介绍：
Journal of Clinical Periodontology was founded by the British, Dutch, French, German, Scandinavian, and Swiss Societies of Periodontology.
The aim of the Journal of Clinical Periodontology is to provide the platform for exchange of scientific and clinical progress in the field of Periodontology and allied disciplines, and to do so at the highest possible level. The Journal also aims to facilitate the application of new scientific knowledge to the daily practice of the concerned disciplines and addresses both practicing clinicians and academics. The Journal is the official publication of the European Federation of Periodontology but wishes to retain its international scope.
The Journal publishes original contributions of high scientific merit in the fields of periodontology and implant dentistry. Its scope encompasses the physiology and pathology of the periodontium, the tissue integration of dental implants, the biology and the modulation of periodontal and alveolar bone healing and regeneration, diagnosis, epidemiology, prevention and therapy of periodontal disease, the clinical aspects of tooth replacement with dental implants, and the comprehensive rehabilitation of the periodontal patient. Review articles by experts on new developments in basic and applied periodontal science and associated dental disciplines, advances in periodontal or implant techniques and procedures, and case reports which illustrate important new information are also welcome.
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