Journal of Basic and Clinical Physiology and Pharmacology最新文献_第3页

Ascorbic acid attenuates lead-induced oxidative stress and testosterone suppression in male Wistar rats. 抗坏血酸减轻铅诱导的雄性Wistar大鼠氧化应激和睾酮抑制。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2026-05-26 eCollection Date: 2026-07-01 DOI: 10.1515/jbcpp-2026-0042

Ifeanyi Gideon Aja, Mario Adesanya Adelaja, Olawale Olusoga Olubi, Olusegun David Avungbeto

{"title":"Ascorbic acid attenuates lead-induced oxidative stress and testosterone suppression in male Wistar rats.","authors":"Ifeanyi Gideon Aja, Mario Adesanya Adelaja, Olawale Olusoga Olubi, Olusegun David Avungbeto","doi":"10.1515/jbcpp-2026-0042","DOIUrl":"10.1515/jbcpp-2026-0042","url":null,"abstract":"Objectives: Lead (Pb) exposure is a major environmental risk factor for male reproductive dysfunction, primarily mediated through oxidative stress and endocrine disruption. This study evaluated the effects of lead acetate on testicular antioxidant status and serum testosterone levels and investigated the ameliorative role of ascorbic acid (AA) in adult male Wistar rats.Methods: Thirty-five male Wistar rats were randomly assigned to seven groups (n=5): control, low- and high-dose lead (100 and 200 mg/kg), lead plus AA cotreatment, and withdrawal groups. Testicular antioxidant enzymes (SOD, CAT, GPx), reduced glutathione (GSH), and malondialdehyde (MDA) were assessed spectrophotometrically. Serum testosterone was measured using enzyme immunoassay. Data were analyzed using one-way ANOVA (p<0.05).Results: Lead exposure significantly increased MDA levels and reduced antioxidant enzyme activities and testosterone concentrations in a dose-dependent manner (p<0.05). Ascorbic acid coadministration significantly restored antioxidant status, elevated GSH levels, reduced lipid peroxidation, and improved testosterone levels compared with lead-only and withdrawal groups.Conclusions: Lead acetate induces oxidative and endocrine disturbances in testicular tissue. Ascorbic acid effectively mitigates lead-induced reproductive toxicity by preserving antioxidant defenses and maintaining testosterone homeostasis.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"345-354"},"PeriodicalIF":0.0,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148015775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered semen fluid dynamics in smokers: a study on delayed liquefaction and increased viscosity. 吸烟者精液流体动力学的改变：延迟液化和粘度增加的研究。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2026-05-25 eCollection Date: 2026-05-01 DOI: 10.1515/jbcpp-2026-0003

Praveena Meyyazhagan, Sanjeev Kumar Sundararaju, Priyadharshini Valluvan, Nagashree Ramaswamy

{"title":"Altered semen fluid dynamics in smokers: a study on delayed liquefaction and increased viscosity.","authors":"Praveena Meyyazhagan, Sanjeev Kumar Sundararaju, Priyadharshini Valluvan, Nagashree Ramaswamy","doi":"10.1515/jbcpp-2026-0003","DOIUrl":"10.1515/jbcpp-2026-0003","url":null,"abstract":"Objectives: Male reproductive health is vital for societal stability, and lifestyle-related factors significantly influence fertility. Tobacco smoking is a major modifiable risk factor implicated in male infertility. This study aimed to assess differences in semen fluid dynamics and quality parameters between smokers and nonsmokers.Methods: This observational, cross-sectional study was conducted at PSGIMS&R, Coimbatore. Seventy-four males aged 20-50 years were enrolled. A detailed clinical history was obtained, and semen analysis was performed according to WHO 2010 guidelines. Statistical analysis was carried out using SPSS version 23.0, with p<0.05 considered statistically significant.Results: Baseline characteristics did not differ significantly between smokers and nonsmokers. Smokers showed a significantly higher rate of increased semen turbidity (29 vs. 1 %, p=0.002) and delayed liquefaction time (43 vs. 1 %, p=0.002). Mean sperm motility (49.90 vs. 59.45 %, p=0.01) and vitality (42.71 vs. 50.70 %, p=0.04) were significantly reduced among smokers. Regression analysis indicated that coffee consumption, reported by all smokers, did not act as a confounding variable.Conclusions: Tobacco smoking has a deleterious effect on semen fluid dynamics, resulting in delayed liquefaction and increased turbidity, along with reduced sperm motility and vitality, thereby negatively impacting male fertility.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"255-261"},"PeriodicalIF":0.0,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148005295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Achalasia today and tomorrow: surgery between robotic precision, functional phenotyping, and data-driven medicine. 失弛缓症的今天和明天：机器人精确性、功能表型和数据驱动医学之间的手术。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2026-05-18 eCollection Date: 2026-05-01 DOI: 10.1515/jbcpp-2026-0004

Agostino Fernicola, Alfonso Santangelo, Luigi Ricciardelli, Giacomo Benassai, Gennaro Quarto

引用次数: 0

Effect of diuretics, angiotensin receptor blockers and beta-blockers on the quality of life among heart failure patients in a tertiary care hospital in North India. 利尿剂、血管紧张素受体阻滞剂和受体阻滞剂对印度北部三级医院心力衰竭患者生活质量的影响

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2026-05-18 eCollection Date: 2026-07-01 DOI: 10.1515/jbcpp-2026-0080

Moksha Gupta, Neha Rani, Savita Devi, Jayant Kumar Kairi, Amandeep Singh Kaloti

{"title":"Effect of diuretics, angiotensin receptor blockers and beta-blockers on the quality of life among heart failure patients in a tertiary care hospital in North India.","authors":"Moksha Gupta, Neha Rani, Savita Devi, Jayant Kumar Kairi, Amandeep Singh Kaloti","doi":"10.1515/jbcpp-2026-0080","DOIUrl":"10.1515/jbcpp-2026-0080","url":null,"abstract":"Objectives: Patients with chronic heart failure (CHF) often experience poor quality of life as a result of difficulties in performing daily activities and impaired psychological health. This study aims to assess the association between the drugs and quality of life in CHF patients.Methods: The study included CHF patients admitted to Kalpana Chawla Government Medical College, Karnal, over a two-month period. Quality of life was assessed using the Minnesota Living with Heart Failure questionnaire (MLHFQ) after 4 weeks of drug therapy.Results: Among 67 enrolled CHF patients, the majority were aged 50-59 years, and females constituted most of the study population. Most participants (80.6 %) had lower MLHFQ scores. Patients on the four-drug regimen had a lower median score of 14 (IQR: 9-20), with a mean score of 14.69 ± 8.19, compared with other groups. There were no statistically significant differences in total or domain-specific scores between treatment groups (p>0.05).Conclusions: Although lower MLHFQ scores were observed in patients receiving multidrug therapy, this indicates an association rather than causal effects and should be interpreted with caution. Further large-scale, prospective studies are required to evaluate the relationship between drugs and quality of life in CHF patients.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"337-343"},"PeriodicalIF":0.0,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147941770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation the reno-protective effect of tadalafil alone and in combination with ascorbic acid in AKI model in rats. 评价他达拉非单用及联合抗坏血酸对AKI模型大鼠肾保护作用。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2026-05-18 eCollection Date: 2026-09-01 DOI: 10.1515/jbcpp-2026-0077

Tabarek Mohamed Salih, Majid Bashara

{"title":"Evaluation the reno-protective effect of tadalafil alone and in combination with ascorbic acid in AKI model in rats.","authors":"Tabarek Mohamed Salih, Majid Bashara","doi":"10.1515/jbcpp-2026-0077","DOIUrl":"10.1515/jbcpp-2026-0077","url":null,"abstract":"Background: Acute kidney injury (AKI) is associated with increased morbidity, prolonged hospitalization, and mortality, particularly in high-risk patients.Objectives: This study aimed to evaluate the potential reno-protective effects of Tadalafil, a selective phosphodiesterase-5 (PDE-5) inhibitor, alone and in combination with ascorbic acid, in a cisplatin-induced AKI rat model.Methods: Thirty male albino rats (250-300 g) were randomly divided into five groups: control (A), cisplatin-treated (B), ascorbic acid-treated (100 mg/kg) (C), Tadalafil-treated (5 mg/kg) (D), and combined ascorbic acid + Tadalafil (E). Treatments were administered for 10 days prior to a single intraperitoneal dose of cisplatin (10 mg/kg). After 72 h, blood and kidney tissue samples were collected for biochemical and histopathological analyses. Serum urea and creatinine, as well as renal tissue levels of NGAL, SOD, and TNF-α, were evaluated.Results: Cisplatin significantly increased urea, creatinine, TNF-α, and NGAL levels, while reducing SOD compared to control. Pre-treatment with Tadalafil, alone or in combination with ascorbic acid, significantly ameliorated these alterations.Conclusions: Tadalafil in combination with ascorbic acid shows enhanced protective effects, suggesting greater protective effect role. Further studies are required to confirm its clinical applicability.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"387-394"},"PeriodicalIF":0.0,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147941784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel SGLT2 inhibitors with endothelial-protective potential: a combined computational and experimental approach. 具有内皮保护潜能的新型SGLT2抑制剂：一种计算和实验相结合的方法。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2026-05-14 eCollection Date: 2026-07-01 DOI: 10.1515/jbcpp-2025-0147

Jarritt Romanik, Nina Gardella, Gabriela Dematteo, Yiru Zhao, Timothy Moy, Asher Brandt, Zhao Li

{"title":"Novel SGLT2 inhibitors with endothelial-protective potential: a combined computational and experimental approach.","authors":"Jarritt Romanik, Nina Gardella, Gabriela Dematteo, Yiru Zhao, Timothy Moy, Asher Brandt, Zhao Li","doi":"10.1515/jbcpp-2025-0147","DOIUrl":"10.1515/jbcpp-2025-0147","url":null,"abstract":"Objectives: Sodium-glucose co-transporter 2 (SGLT2) inhibitors are a class of anti-diabetic drugs with cardiovascular benefits independent of glycemic control, partly via endothelial protection. Identifying novel inhibitors with both high affinity and vascular-protective effects remains a priority.Methods: Structure-based high-throughput virtual screening (HTVS) of 14 million ligands was performed using Schrödinger Glide. Compounds with better docking scores than empagliflozin (-13.615) were filtered for ADME properties using QikProp. Ten lead compounds were evaluated in human coronary artery endothelial cells under diabetic and ischemia-reperfusion (I/R) models. Assays included glucose uptake, cytotoxicity (LDH), oxidative stress (ROS), and nitrosative stress (NO).Results: Compound #7 demonstrated the most potent activity, reducing glucose uptake by 55 % (p<0.01), ROS by 48 % (p<0.05), and NO by 47 % (p<0.05). LDH release decreased 16 % under diabetic stress and 20 % under I/R injury (both p<0.05).Conclusions: Compound #7 is a novel SGLT2 inhibitor with dual glucose-lowering and endothelial-protective effects. These findings highlight the utility of HTVS for rapid lead identification and support further development of compound #7 as a potential therapeutic agent targeting metabolic and vascular complications of diabetes.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"305-314"},"PeriodicalIF":0.0,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147929997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative oncology of male and female breast cancer: diagnostic paradigms and machine learning approaches in treatment. 男性和女性乳腺癌的比较肿瘤学：诊断范例和治疗中的机器学习方法。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2026-05-11 eCollection Date: 2026-05-01 DOI: 10.1515/jbcpp-2026-0005

Joy Das, Utpal Bhui, Gouri Shankar Chakraborty, Dipen Mazumder, Sagar Shil, Ashok Kumar Sah, Borony Akter, Jahid Hossain, Soumyadip Nayak, Souvik Basak, Biplab Debnath, Rajarshi Nath, Sathvik Belagodu Sridhar, Uttam Prasad Panigrahy

{"title":"Comparative oncology of male and female breast cancer: diagnostic paradigms and machine learning approaches in treatment.","authors":"Joy Das, Utpal Bhui, Gouri Shankar Chakraborty, Dipen Mazumder, Sagar Shil, Ashok Kumar Sah, Borony Akter, Jahid Hossain, Soumyadip Nayak, Souvik Basak, Biplab Debnath, Rajarshi Nath, Sathvik Belagodu Sridhar, Uttam Prasad Panigrahy","doi":"10.1515/jbcpp-2026-0005","DOIUrl":"10.1515/jbcpp-2026-0005","url":null,"abstract":"Breast cancer is associated mostly with women; however, breast cancer also appears in men, which dictates the need to know about gender-specific differences in the pathology and treatment. Male breast cancer constitutes less than 1 % of all cases and is usually diagnosed when the patient is older, with bigger tumors and at later stages than breast cancer in women. The most widespread subtype in both genders is invasive ductal carcinoma. The effect of hormone receptor positivity is very prominent in the treatment of men, and the risk factors include the BRCA2 mutations and the hormonal imbalance. The management approach, such as surgery, chemotherapy, radiotherapy, and hormonal therapy, is like that of women, and it may vary in treatment effectiveness because of hormonal and biological differences. The prognostic data in males are scarce, with generally worse outcomes, most likely because of delayed diagnosis and low rates of clinical trial representation. Men with breast cancer also face special psychosocial obstacles with regard to stigma and support. The use of artificial intelligence (AI) and machine learning are emerging options that have the potential to improve detectability and personalized treatment in both genders. The current review draws similarities between breast cancer in males and females to promote gender-specific interventions and better outcomes.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"169-199"},"PeriodicalIF":0.0,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147868727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in drug-induced liver injury (DILI): a case report-based analysis of clinical presentation, severity, preventability, seriousness, and outcomes over the last decade. 药物性肝损伤（DILI）的趋势：过去十年中基于病例报告的临床表现、严重程度、可预防性、严重性和结果分析。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2026-04-23 eCollection Date: 2026-07-01 DOI: 10.1515/jbcpp-2026-0012

Saurav Misra, Jayant Kumar Kairi, Manmeet Kaur, Babita Sheoron, Sushant Gupta, Mayur Tuteja

{"title":"Trends in drug-induced liver injury (DILI): a case report-based analysis of clinical presentation, severity, preventability, seriousness, and outcomes over the last decade.","authors":"Saurav Misra, Jayant Kumar Kairi, Manmeet Kaur, Babita Sheoron, Sushant Gupta, Mayur Tuteja","doi":"10.1515/jbcpp-2026-0012","DOIUrl":"10.1515/jbcpp-2026-0012","url":null,"abstract":"Background: DILI causes about 50 % of acute liver failures globally, affecting 14-19 per 100,000 annually, and is a leading cause of liver failure and drug withdrawals in the USA and Europe.Methods: This study reviewed 60 case reports of drug-induced liver injury from Medline/PubMed (2015-2025) at Kalpana Chawla Government Medical College. Initially, 108 reports were identified using specific criteria, screened independently by two teams, with duplicates and ineligible reports removed for analysis.Results: This analysis of 60 drug-induced liver injury case reports from PubMed/Medline in past decade found that patients averaged 54.6 years old, with 55 % female. Most cases occurred in the USA, China, and Japan. Jaundice (42 %) and fatigue (34 %) were common symptoms. Hepatocellular injury was most prevalent (45 %). Atorvastatin and Methimazole were frequently implicated drugs, with 75 % involving polypharmacy. Most ADRs occurred within 2.3 months of treatment initiation. Drug withdrawal was the primary intervention (93 %), resulting in full recovery in 87 % of cases, though 3 % were fatal.Conclusions: Analysis of 60 DILI cases identified risk factors such as age over 55, female sex, high doses, and polypharmacy. Most cases were drug-related; 78 % required hospitalization. Prevention could reduce cases by up to 50 %, with full recovery upon drug withdrawal.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"315-323"},"PeriodicalIF":0.0,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypoxia-induced cisplatin resistance in cancer: a comprehensive exploration of molecular mechanisms and novel therapeutic strategies. 低氧诱导的癌症顺铂耐药：分子机制和新治疗策略的综合探索。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2026-03-17 eCollection Date: 2026-03-01 DOI: 10.1515/jbcpp-2025-0092

Malchi Suresh, Sakthivel Manju Bargavi, Kodiganti Naresh Kumar, Namani Sreevani, Devarajan Nalini

{"title":"Hypoxia-induced cisplatin resistance in cancer: a comprehensive exploration of molecular mechanisms and novel therapeutic strategies.","authors":"Malchi Suresh, Sakthivel Manju Bargavi, Kodiganti Naresh Kumar, Namani Sreevani, Devarajan Nalini","doi":"10.1515/jbcpp-2025-0092","DOIUrl":"10.1515/jbcpp-2025-0092","url":null,"abstract":"Tumor hypoxia is a critical contributor to cisplatin resistance, promoting molecular adaptations such as HIF-1α activation, reduced DNA repair capacity, metabolic reprogramming, and exosome-mediated drug efflux that collectively weaken cisplatin-induced cytotoxicity. This review integrates current evidence on these hypoxia-driven mechanisms and emphasizes how spatially heterogeneous hypoxic niches generate tumor subpopulations with distinct resistance profiles. Two therapeutic strategies show promising potential to counter this challenge: adjunct therapies that target hypoxia-related signaling and metabolic pathways, including HIF inhibitors, HDAC inhibitors, natural compounds, and metabolic modulators, and oxygenation approaches designed to reverse hypoxic stress. Notably, advances in nanotechnology-based oxygen-delivery systems provide sustained, localized reoxygenation of hypoxic regions, addressing limitations of conventional oxygen therapies. Although these interventions demonstrate strong preclinical efficacy, translation to consistent clinical benefit remains limited, partly due to inadequate hypoxia biomarkers and insufficient preclinical models that fail to replicate tumor oxygen gradients. Future progress will require biomarker-guided patient selection, optimized combination regimens, and early clinical evaluation of oxygen-delivery platforms to enhance cisplatin sensitivity and reduce hypoxia-driven chemoresistance.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"105-118"},"PeriodicalIF":0.0,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147473813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of osteoarthritis using integrated approach: a meta-analysis. 综合治疗骨关节炎：一项荟萃分析。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2026-02-06 eCollection Date: 2026-05-01 DOI: 10.1515/jbcpp-2025-0142

Faizal E Kottikollon, Ravi S Parihar

{"title":"Management of osteoarthritis using integrated approach: a meta-analysis.","authors":"Faizal E Kottikollon, Ravi S Parihar","doi":"10.1515/jbcpp-2025-0142","DOIUrl":"10.1515/jbcpp-2025-0142","url":null,"abstract":"Objectives: Osteoarthritis (OA) is a degenerative joint disease affecting millions worldwide, causing disability, reduced quality of life, and significant economic burden. Current clinical practices often fail to provide optimal symptom relief and functional improvement, necessitating evidence-based evaluation of integrated management strategies. This systematic literature review to identify effective integrated interventions for alleviating OA symptoms, enhancing functional outcomes, and improving patient adherence and satisfaction.Methods: A systematic literature review was conducted following PRISMA guidelines. Peer-reviewed articles published between 2000 and 2024 were retrieved from major scientific databases, including PubMed, Science Direct, Springer Link, Elsevier, Taylor & Francis, and Google Scholar. Studies evaluating integrated or multidisciplinary approaches for OA management were included.Results: Integrated management strategies demonstrated superior outcomes compared with isolated interventions. Pain reduction was reported in 28 out of 32 studies, with significant improvements in joint function, mobility, and quality of life. Nonpharmacological components enhanced pharmacological treatments. Patient adherence increased by 30-45 % with integrated care. Key barriers implementation included fragmented health care systems, lack of provider training, and inconsistent insurance coverage.Conclusions: Integrated approaches to OA management provide clinically meaningful improvements in pain, function, and patient-centered outcomes. These SLR actionable insights are for optimizing OA management through holistic, patient-centered strategies. Future research should prioritize cost-effectiveness analyses and long-term outcomes of integrated models.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"243-254"},"PeriodicalIF":0.0,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146207111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0