Journal of Basic and Clinical Physiology and Pharmacology最新文献_第3页

CONTENTS. 内容。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-04-10 Print Date: 1994-01-01 DOI: 10.1515/jbcpp-1994-toc0501

引用次数: 0

Magnesium Protects Against Anaphylactic Shock and Cardiac Myolysis in Guinea-Pigs. 镁对豚鼠过敏性休克和心肌溶解的保护作用。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-04-10 Print Date: 1994-01-01 DOI: 10.1515/jbcpp-1994-050104

Fabio Kusniec, Gabriella Fischer, Ben-Ami Sela, Yaakov Ashkenazy, Dan Fiegel, Sandra Moshonov, Uriel Zor

{"title":"Magnesium Protects Against Anaphylactic Shock and Cardiac Myolysis in Guinea-Pigs.","authors":"Fabio Kusniec, Gabriella Fischer, Ben-Ami Sela, Yaakov Ashkenazy, Dan Fiegel, Sandra Moshonov, Uriel Zor","doi":"10.1515/jbcpp-1994-050104","DOIUrl":"https://doi.org/10.1515/jbcpp-1994-050104","url":null,"abstract":"The pathophysiological responses to immune stress (IS) include activation of several processes which are dependent on cytosolic Ca2+ elevation. Magnesium frequently acts as a natural Ca2+ antagonist. In this study we have observed that Mg2 + can protect guinea-pigs against IS. Antigen-sensitized guinea-pigs, which had been fed a magnesiumdeficient diet, were given a single dose (15 mg) of MgCl2 intraperitoneally 1 h before antigen challenge. The development of anaphylactic shock (AS) was observed during the next 2 h, and the hearts were subsequently examined histologically for signs of cardiac myolysis (CM). Magnesium (i) reduced the incidence of CM from 40% to 10% (p<0.05); (ii) reduced the incidence of AS from 61% to 35% (p<0.05); (iii) attenuated the severity of the AS; and (iv) lowered mortality from 39% in the control to 19% in the Mg2+-treated group (p=0.1). Serum and tissue total [Mg2+] were not affected by the administration of MgCl2. Also, the serum and heart Mg2+ levels were the same whether or not the guinea-pigs developed AS or CM. In cell culture we demonstrated that by elevating the [Mg2+] in the medium bathing sensitized rat basophilic leukemia (RBL) cells, the increase in cytosolic [Ca2+] subsequent to antigen challenge was reduced from 174 ± 23.28% (1 mM) to 82.74 ± 13.22 % (3 mM). We conclude that a single treatment with Mg2+ can considerably diminish damage induced by immune stress, probably by its altering the Ca2+: Mg2+ratio. Since the physiological reaction to different types of stress is similar, Mg2 + could prove beneficial in preventing stress-induced shock in general. Studies examining the mechanisms by which Mg2 + exerts its effects thus provide a scientific basis for the current clinical use of Mg2 + in acute myocardial infarction (AMI) and asthma.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":"5 1","pages":"45-58"},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A New Class of Antiarrhythmic-Defibrillatory Compounds. 一类新的抗心律失常除颤剂化合物。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-04-10 Print Date: 1994-01-01 DOI: 10.1515/jbcpp-1994-050105

M Erez, D Varon

引用次数: 0

Dehydration and Rehydration in Donkeys: The Role of the Hind Gut as a Water Reservoir. 驴的脱水和补液：后肠作为贮水器的作用。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-04-10 Print Date: 1994-01-01 DOI: 10.1515/jbcpp-1994-050107

H Kasirer-Izraely, I Choshniak, A Shkolnik

{"title":"Dehydration and Rehydration in Donkeys: The Role of the Hind Gut as a Water Reservoir.","authors":"H Kasirer-Izraely, I Choshniak, A Shkolnik","doi":"10.1515/jbcpp-1994-050107","DOIUrl":"https://doi.org/10.1515/jbcpp-1994-050107","url":null,"abstract":"Body fluid distribution was measured in three donkeys, fully hydrated, following dehydration and after being rapidly rehydrated. In twenty other donkeys that were slaughtered to supply food for predators iri a safari zoo, the water content in the different compartments of the gastrointestinal tract (GIT) was assessed. Prior to being slaughtered, four of the animals were fully hydrated, four dehydrated and 12 dehydrated, rehydrated and then slaughtered and examined, four at 1, four at 3 and four at 5 hours following drinking. When the body mass of dehydrated donkeys dropped to 75.4± 2.4% of their initial value, total body water of the animals (HTO space), extracellular volume (SCN space) and plasma volume (EB space) were reduced to 76.6 ± 5.3%, 80.9 ± 10.6% and 73.2 ± 8.3% of their initial values, respectively. The amount of water retained in the GIT of the fully hydrated donkeys amounted to 15.9 ± 3.4 1, 19% of total body water. In the dehydrated donkeys it was only 7.4± 1.3 1. The calculated total intracellular volume in the dehydrated donkeys was only 14% lower than in the fully hydrated animals. When drinking was allowed, dehydrated donkeys consumed 17.6 ± 2.4 1 of water. The increase in the water content in the gut of newly rehydrated donkeys matched this volume, 80% of which was retained in the hind gut. During the five hours after drinking, only slow and moderate changes in the volume of the hind gut were recorded. Changes in plasma volume were also suppressed. It is suggested that the hind gut of the donkey, similar to the rumen of goats and sheep, plays a role as a water reservoir that helps maintain the osmotic stability of the body.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":"5 1","pages":"89-100"},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ion-Selective Channels in K562 Cells: A Patch-Clamp Analysis. K562细胞中的离子选择通道：一个膜片钳分析。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-04-10 Print Date: 1994-01-01 DOI: 10.1515/jbcpp-1994-050103

Jürgen Rettinger, Wolfgang Schwarz

{"title":"Ion-Selective Channels in K562 Cells: A Patch-Clamp Analysis.","authors":"Jürgen Rettinger, Wolfgang Schwarz","doi":"10.1515/jbcpp-1994-050103","DOIUrl":"https://doi.org/10.1515/jbcpp-1994-050103","url":null,"abstract":"Four types of ion-selective channels were found by the patch-clamp technique in the human erythroleucemia K562 cells. I)In cell-attached configuration at potentials less negative than -40 mV an 8 pS channel was detected. The potential dependence of channel activity suggests that this is the TTX-sensitive Na+ channel. II)A cation-selective channel was observed with equal permeability for Na+ and K+ and a potential-independent single-channel conductance of 19 pS. The channel is activated by intracellular Ca2+ and inhibited by TEA. ΙΠ)A predominantly anion-selective channel was identified with the selectivity sequence N03\" >J\" > G\" = Br » S04 2·. The single-channel conductance shows outward rectification, and is in symmetrical NaCl solution 19 pS at -60 mV and 54 pS at +50 mV. The open- and closedtime distributions suggest one open and at least four closed states. At submicromolar concentrations, the open state is blocked by H2DIDS leading to channel flicker between open and blocked channel; higher concentrations (apparent Kj=6.8 μΜ) lead to a longer-lasting blocked state. Both components of inhibition are reversible. IV)In addition, an 8 pS, Na+- and K+- selective channel could be induced by application of palytoxin. For channel activity, the presence of extracellular Na+ is essential. It is assumed that the Na+, K+-pump molecule is involved in the channel formation. Similarly, it is discussed whether the anionselective channel represents a pore conformation of an electrically silent anion exchanger.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":"5 1","pages":"27-44"},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anions, Membrane Resistance and Ventricular Fibrillation. 阴离子、膜阻力与心室颤动。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-04-10 Print Date: 1994-01-01 DOI: 10.1515/jbcpp-1994-050102

Michael J Curtis, Paul D Ridley

引用次数: 0

Chemical Defibrillation in Acute Myocardial Ischaemia: a Hypothesis. 急性心肌缺血的化学除颤：一个假说。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-04-10 Print Date: 1994-01-01 DOI: 10.1515/jbcpp-1994-050101

Michael J Curtis

引用次数: 0

Point-of-care testing: revolutionizing clinical biochemistry using decentralized diagnostics. 即时检测：使用分散式诊断革新临床生物化学。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-04-04 eCollection Date: 2025-03-01 DOI: 10.1515/jbcpp-2025-0029

Simran Shaikh, Sanjyoti A Panchbudhe, Rajni R Shivkar, Arnab Banerjee, Paulami Deshmukh, Charushila Y Kadam

{"title":"Point-of-care testing: revolutionizing clinical biochemistry using decentralized diagnostics.","authors":"Simran Shaikh, Sanjyoti A Panchbudhe, Rajni R Shivkar, Arnab Banerjee, Paulami Deshmukh, Charushila Y Kadam","doi":"10.1515/jbcpp-2025-0029","DOIUrl":"10.1515/jbcpp-2025-0029","url":null,"abstract":"Point-of-care testing (POCT) refers to decentralized testing done using complex but compact, portable devices that can be done near the site at the patient's bedside. These enable quick diagnosis and timely intervention because turnaround time (TAT) decreases with these devices. They can also be operated by non-medical personnel and patients with minimum expertise as these devices are easy to handle and interpret. This increases patient awareness regarding their diseases and benefits doctors in giving more patient-centered care. POCT devices require minimum setup and can be utilized even in remote places. The present review focuses on POCT devices employed specifically in clinical biochemistry, e.g., glucose, HbA1c, cardiac biomarkers, fertility tests, hematological analysis, electrolytes, enzymes, urine dipstick tests, etc. This introductory review delves into comprehending the fundamentals of POCT technologies, their guidelines, applications, advantages, and disadvantages. It covers a broad overview of the tests done and the samples required to process these tests. It also compares the pros and cons of POCT devices over centralized laboratory testing. The review also aims to emphasize the relevance of its use in today's era, current trends regarding POCT in urban and rural setups, challenges faced in the field during its implementation, and the potential areas of improvement in the future. However, it is advisable to seek references for more detailed and critical information regarding all the specific topics given in this review article.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"113-128"},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Approaching a phenomenal contradiction in acid-base physiology. 接近酸碱生理学中一个显著的矛盾。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-03-31 eCollection Date: 2025-03-01 DOI: 10.1515/jbcpp-2025-0016

Stelios Kokkoris, Kyriakos Trigkidis, Dimitrios-Dorotheos Papadakis, Dimitrios Kostarakis, Nikolaos Gialelis, Ioannis Vasileiadis

{"title":"Approaching a phenomenal contradiction in acid-base physiology.","authors":"Stelios Kokkoris, Kyriakos Trigkidis, Dimitrios-Dorotheos Papadakis, Dimitrios Kostarakis, Nikolaos Gialelis, Ioannis Vasileiadis","doi":"10.1515/jbcpp-2025-0016","DOIUrl":"10.1515/jbcpp-2025-0016","url":null,"abstract":"Objectives: The study focuses exclusively on the results of an arterial blood gas report, which reveal a phenomenal contradiction if one follows the physiological and physicochemical approaches as well as the standard base excess determination to interpret an acid-base disturbance. The aim of this article is not to fully describe a clinical case and make a differential diagnosis but to analyze the blood gas report data in detail and present the conclusions that result from the application of the different approaches that exist for the interpretation of acid-base disorders.Methods: The results of an arterial blood gas report of a patient with severe lactic acidosis were cross-examined using the standard base excess method and the physiologic and physiochemical approaches. The causes of the contradiction are discussed with a commentary on the underlying pathophysiology.Results: The study revealed the presence of a normal anion gap (even after correction for albumin levels), a slightly increased strong ion gap and a moderately decreased standard base excess in a patient with severe lactic acidosis.Conclusions: This real-life case provides an opportunity to give a brief overview of the current methods for investigating acid-base disturbances in a practical way, emphasizing both the common background and the conceptual differences and similarities.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"229-235"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incretin-based therapies: advancements, challenges, and future directions in type 2 diabetes management. 基于肠促胰岛素的治疗：2型糖尿病治疗的进展、挑战和未来方向。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-03-31 eCollection Date: 2025-03-01 DOI: 10.1515/jbcpp-2025-0031

Amruth A Alluri, Yashaswi Guntupalli, Shruti Suresh Suvarna, Yuliya Prystupa, Shrishti Prakash Khetan, Bharath Vejandla, Naraginti Lenin Babu Swathi

{"title":"Incretin-based therapies: advancements, challenges, and future directions in type 2 diabetes management.","authors":"Amruth A Alluri, Yashaswi Guntupalli, Shruti Suresh Suvarna, Yuliya Prystupa, Shrishti Prakash Khetan, Bharath Vejandla, Naraginti Lenin Babu Swathi","doi":"10.1515/jbcpp-2025-0031","DOIUrl":"10.1515/jbcpp-2025-0031","url":null,"abstract":"Incretin-based medicines have considerably impacted the treatment of type 2 diabetes mellitus (T2DM), providing considerable advantages in glycemic regulation, weight control, and cardiovascular results. This narrative review examines progress in incretin medicines, encompassing glucagon-like peptide-1 (GLP-1) receptor agonists, dual-receptor, and triple-receptor agonists, while emphasizing their therapeutic advantages, obstacles, and prospective developments. The examined articles were sourced from databases including PubMed and Google Scholar, concentrating on publications predominantly from 2010 to 2024. Selective foundational papers released before this timeline were incorporated to furnish critical historical context about incretin processes and their discovery. Incretin-based medicines, despite their therapeutic efficacy, encounter hurdles including elevated treatment costs, patient compliance difficulties, and variability in response attributable to genetic and physiological variables. Moreover, there are still deficiencies in comprehending the long-term cardiovascular safety and cancer risks linked to these medicines. Emerging dual- and triple-receptor agonists demonstrate potential in overcoming the shortcomings of conventional GLP-1 receptor agonists, providing enhanced metabolic results and broader uses in intricate disease profiles. Future research must concentrate on economic obstacles, streamlined regimens, customized medicine, the integration of artificial intelligence, patient stratification, as well as the safety and efficacy of incretin-based medicines for holistic management of T2DM.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"95-111"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0