Journal of Basic and Clinical Physiology and Pharmacology最新文献_第4页

Exploring the impact of vitamin D on tendon health: a comprehensive review. 探讨维生素 D 对肌腱健康的影响：综合综述。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2024-05-23 eCollection Date: 2024-05-01 DOI: 10.1515/jbcpp-2024-0061

Domiziano Tarantino, Rosita Mottola, Felice Sirico, Bruno Corrado, Carlo Ruosi, Raoul Saggini, Raffaello Pellegrino

{"title":"Exploring the impact of vitamin D on tendon health: a comprehensive review.","authors":"Domiziano Tarantino, Rosita Mottola, Felice Sirico, Bruno Corrado, Carlo Ruosi, Raoul Saggini, Raffaello Pellegrino","doi":"10.1515/jbcpp-2024-0061","DOIUrl":"10.1515/jbcpp-2024-0061","url":null,"abstract":"Tendons are vital components of the musculoskeletal system, facilitating movement and supporting mechanical loads. Emerging evidence suggests that vitamin D, beyond its well-established role in bone health, exerts significant effects on tendon physiology. The aim of this manuscript is to review the impact of vitamin D on tendons, focusing on its mechanisms of action, clinical implications, and therapeutic applications. A comprehensive search of scientific electronic databases was conducted to identify articles on the effects of vitamin D on tendon health. Fourteen studies were included in this review. Five studies were performed in vitro, and nine studies were conducted in vivo. Despite some conflicting results, the included studies showed that vitamin D regulates collagen synthesis, inflammation, and mineralization within tendons through its interaction with vitamin D receptors. Epidemiological studies link vitamin D deficiency with tendon disorders, including tendinopathy and impaired healing. Supplementation with vitamin D shows promise in improving tendon strength and function, particularly in at-risk populations such as athletes and the elderly. Future research should address optimal supplementation strategies and explore the interplay between vitamin D and other factors influencing tendon health. Integrating vitamin D optimization into clinical practice could enhance tendon integrity and reduce the burden of tendon-related pathologies.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"143-152"},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel variant in the FLNB gene associated with spondylocarpotarsal synostosis syndrome. 与脊柱腕骨趾骨突触综合征有关的 FLNB 基因新变异。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2024-05-16 eCollection Date: 2024-05-01 DOI: 10.1515/jbcpp-2024-0031

Hina Qasim, Hayat Khan, Humaira Zeb, Akmal Ahmad, Muhammad Ilyas, Muhammad Zahoor, Muhammad Naveed Umar, Riaz Ullah, Essam A Ali

{"title":"A novel variant in the FLNB gene associated with spondylocarpotarsal synostosis syndrome.","authors":"Hina Qasim, Hayat Khan, Humaira Zeb, Akmal Ahmad, Muhammad Ilyas, Muhammad Zahoor, Muhammad Naveed Umar, Riaz Ullah, Essam A Ali","doi":"10.1515/jbcpp-2024-0031","DOIUrl":"10.1515/jbcpp-2024-0031","url":null,"abstract":"Objectives: Genetic disorders involved in skeleton system arise due to the disturbance in skeletal development, growth and homeostasis. Filamin B is an actin binding protein which is large dimeric protein which cross link actin cytoskeleton filaments into dynamic structure. A single nucleotide changes in the FLNB gene causes spondylocarpotarsal synostosis syndrome, a rare bone disorder due to which the fusion of carpels and tarsals synostosis occurred along with fused vertebrae. In the current study we investigated a family residing in north-western areas of Pakistan.Methods: The whole exome sequencing of proband was performed followed by Sanger sequencing of all family members of the subject to validate the variant segregation within the family. Bioinformatics tools were utilized to assess the pathogenicity of the variant.Results: Whole Exome Sequencing revealed a novel variant (NM_001457: c.209C>T and p.Pro70Leu) in the FLNB gene which was homozygous missense mutation in the FLNB gene. The variant was further validated and visualized by Sanger sequencing and protein structure studies respectively as mentioned before.Conclusions: The findings have highlighted the importance of the molecular diagnosis in SCT (spondylocarpotarsal synostosis syndrome) for genetic risk counselling in consanguineous families.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"181-187"},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140922145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The underlying causes, treatment options of gut microbiota and food habits in type 2 diabetes mellitus: a narrative review. 2 型糖尿病的根本原因、肠道微生物群和饮食习惯的治疗方案：综述。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2024-05-16 eCollection Date: 2024-05-01 DOI: 10.1515/jbcpp-2024-0043

Krishnendu Adhikary, Riya Sarkar, Sriparna Maity, Ipsita Banerjee, Prity Chatterjee, Koushik Bhattacharya, Deepika Ahuja, Nirmalya Kumar Sinha, Rajkumar Maiti

{"title":"The underlying causes, treatment options of gut microbiota and food habits in type 2 diabetes mellitus: a narrative review.","authors":"Krishnendu Adhikary, Riya Sarkar, Sriparna Maity, Ipsita Banerjee, Prity Chatterjee, Koushik Bhattacharya, Deepika Ahuja, Nirmalya Kumar Sinha, Rajkumar Maiti","doi":"10.1515/jbcpp-2024-0043","DOIUrl":"10.1515/jbcpp-2024-0043","url":null,"abstract":"Type 2 diabetes mellitus is a long-lasting endocrine disorder characterized by persistent hyperglycaemia, which is often triggered by an entire or relative inadequacy of insulin production or insulin resistance. As a result of resistance to insulin (IR) and an overall lack of insulin in the body, type 2 diabetes mellitus (T2DM) is a metabolic illness that is characterized by hyperglycaemia. Notably, the occurrence of vascular complications of diabetes and the advancement of IR in T2DM are accompanied by dysbiosis of the gut microbiota. Due to the difficulties in managing the disease and the dangers of multiple accompanying complications, diabetes is a chronic, progressive immune-mediated condition that plays a significant clinical and health burden on patients. The frequency and incidence of diabetes among young people have been rising worldwide. The relationship between the gut microbiota composition and the physio-pathological characteristics of T2DM proposes a novel way to monitor the condition and enhance the effectiveness of therapies. Our knowledge of the microbiota of the gut and how it affects health and illness has changed over the last 20 years. Species of the genus Eubacterium, which make up a significant portion of the core animal gut microbiome, are some of the recently discovered 'generation' of possibly helpful bacteria. In this article, we have focused on pathogenesis and therapeutic approaches towards T2DM, with a special reference to gut bacteria from ancient times to the present day.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"153-168"},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating Majhool date (Phoenix dactylifera) consumption effects on fasting blood glucose in animals and humans. 研究食用马枣（Phoenix dactylifera）对动物和人类空腹血糖的影响。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2024-04-29 eCollection Date: 2024-05-01 DOI: 10.1515/jbcpp-2024-0049

Yazun Jarrar, Ruba Balasmeh, Wisam Naser, Rami Mosleh, Amin A Al-Doaiss, Mohammed Ali AlShehri

{"title":"Investigating Majhool date (Phoenix dactylifera) consumption effects on fasting blood glucose in animals and humans.","authors":"Yazun Jarrar, Ruba Balasmeh, Wisam Naser, Rami Mosleh, Amin A Al-Doaiss, Mohammed Ali AlShehri","doi":"10.1515/jbcpp-2024-0049","DOIUrl":"10.1515/jbcpp-2024-0049","url":null,"abstract":"Objectives: Majhool date (Phoenix dactylifera), renowned for its premium taste and texture, is extensively consumed in the Islamic world, particularly during Ramadan. Despite its popularity, concerns persist regarding its potential to induce diabetes in non-patients. This study aims to explore the diabetogenic effects of prolonged Majhool date (Phoenix dactylifera) consumption, the widely used fruit in the Islamic world, through animal experiments and human clinical data.Methods: Medjool dates were processed into an ethanolic extract for the animal experiment. Then, 21 Balb/c mice received varying doses of the extract for one month. The fasting blood glucose levels were analyzed at the beginning and after one month of consumption of the Majhool date extract. For the clinical study, 387 healthy participants were recruited, with fasting blood glucose levels assessed before and after Ramadan, a period of heightened Majhool date consumption.Results: all groups of the experimental animals exhibited a significant (p<0.05) weight increase after Majhool date consumption, while no significant (p>0.05) alteration in fasting blood glucose levels among groups. In addition, it was found that fasting blood glucose levels remained statistically unchanged (p>0.05) after heightened Majhool date consumption among humans.Conclusions: The study challenges the belief that Majhool date induces diabetes, supported by both animal and human data. Findings suggest that Majhool date consumption, even at higher doses, does not induce diabetes. Further investigations could explore the impact of other date varieties on the fasting blood glucose levels.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"175-179"},"PeriodicalIF":0.0,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140851924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cannabis effectiveness on immunologic potency of pulmonary contagion. 大麻对肺部传染病免疫效力的影响。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2024-04-19 DOI: 10.1515/jbcpp-2023-0030

Sumana Das, Arya Ghosh, Varnita Karmakar, Sourav Khawas, Piyush Vatsha, Kishor Kumar Roy, Padma Charan Behera

{"title":"Cannabis effectiveness on immunologic potency of pulmonary contagion.","authors":"Sumana Das, Arya Ghosh, Varnita Karmakar, Sourav Khawas, Piyush Vatsha, Kishor Kumar Roy, Padma Charan Behera","doi":"10.1515/jbcpp-2023-0030","DOIUrl":"https://doi.org/10.1515/jbcpp-2023-0030","url":null,"abstract":"Respiratory illnesses and its repercussions are becoming more prevalent worldwide. It is necessary to research both innovative treatment and preventative techniques. Millions of confirmed cases and fatalities from the COVID-19 epidemic occurred over the previous two years. According to the review research, cannabinoids are a class of medicines that should be considered for the treatment of respiratory conditions. Cannabinoids and inhibitors of endocannabinoid degradation have illustrated advantageous anti-inflammatory, asthma, pulmonary fibrosis, and pulmonary artery hypotension in numerous studies (in vitro and in vivo). It has been also noted that CB2 receptors on macrophages and T-helper cells may be particularly triggered to lower inflammation in COVID-19 patients. Since the majority of lung tissue contains cannabinoid receptors, cannabis can be an effective medical tool for treating COVID-19 as well as pulmonary infections. Notably, CB2 and CB1 receptors play a major role in immune system modulation and anti-inflammatory activities. In this review, we put forth the idea that cannabis might be helpful in treating pulmonary contagion brought on by viral integration, such as that caused by SARS-CoV-2, haemophilus influenza type b, Streptococcus pneumoniae, influenza virus, and respiratory syncytial virus. Also, a detailed overview of CB receptors, intricate mechanisms, is highlighted connecting link with COVID-19 viral structural modifications along with molecular basis of CB receptors in diminishing viral load in pulmonary disorders supported through evident literature studies. Further, futuristic evaluations on cannabis potency through novel formulation development focusing on in vivo/in vitro systems can produce promising results.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140682816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How should we differentiate hypoglycaemia in non-diabetic patients? 如何区分非糖尿病患者的低血糖症？

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2024-04-16 DOI: 10.1515/jbcpp-2024-0030

Michele Modestino, Olimpia Iacono, Laura Ferrentino, Anna Lombardi, Umberto De Fortuna, Rita Verdoliva, M. De Luca, Vincenzo Guardasole

引用次数: 0

Pozelimab, a human monoclonal immunoglobulin for the treatment of CHAPLE disease. 用于治疗 CHAPLE 病的人单克隆免疫球蛋白 Pozelimab。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2024-04-11 DOI: 10.1515/jbcpp-2024-0008

Manmeet Kaur, Saurav Misra

{"title":"Pozelimab, a human monoclonal immunoglobulin for the treatment of CHAPLE disease.","authors":"Manmeet Kaur, Saurav Misra","doi":"10.1515/jbcpp-2024-0008","DOIUrl":"https://doi.org/10.1515/jbcpp-2024-0008","url":null,"abstract":"The complement is a crucial factor of the innate immune system. However, its activation can lead to various diseases, so it needs to be controlled. In mammals, surface-bound complement regulatory proteins safeguard cells from uncontrolled complement-mediated lysis. One of the human complement regulators is CD55, also known as the decay-accelerating factor (DAF), a single-chain, type I cell surface protein anchored to glycosylphosphatidylinositol (GPI). The genetic loss of the complement regulatory protein CD55 leads to a fatal illness known as CHAPLE disease. The complement and innate immunity become hyperactive in this disease, causing angiopathic thrombosis and protein-losing enteropathy. Patients with CHAPLE disease experience abdominal pain, nausea, vomiting, diarrhea, loss of appetite, weight loss, impaired growth, and swelling. This genetic condition has no known cure, and managing its symptoms can be challenging. Pozelimab, a human monoclonal immunoglobulin IgG4 antibody, is a drug that targets the terminal complement protein C5. The drug has a high affinity for both wild-type and variant human C5. Pozelimab has received designations such as fast track, orphan drug, and rare pediatric disease, making it a significant medical breakthrough. It is currently the only available treatment for this disease. In this review, we have summarized the preclinical and clinical data on pozelimab.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":"48 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140716149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alzheimer's disease and clinical trials. 阿尔茨海默病与临床试验。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2024-03-18 eCollection Date: 2024-01-01 DOI: 10.1515/jbcpp-2023-0264

Deepraj Paul, Rohini Agrawal, Swati Singh

{"title":"Alzheimer's disease and clinical trials.","authors":"Deepraj Paul, Rohini Agrawal, Swati Singh","doi":"10.1515/jbcpp-2023-0264","DOIUrl":"10.1515/jbcpp-2023-0264","url":null,"abstract":"Alzheimer's disease (AD) is spreading its root disproportionately among the worldwide population. Many genes have been identified as the hallmarks of AD. Based upon the knowledge, many clinical trials have been designed and conducted. Attempts have been made to alleviate the pathology associated with AD by targeting the molecular products of these genes. Irrespective of the understanding on the genetic component of AD, many clinical trials have failed and imposed greater challenges on the path of drug discovery. Therefore, this review aims to identify research and review articles to pinpoint the limitations of drug candidates (thiethylperazine, CT1812, crenezumab, CNP520, and lecanemab), which are under or withdrawn from clinical trials. Thorough analysis of the cross-talk pathways led to the identification of many confounding factors, which could interfere with the success of clinical trials with drug candidates such as thiethylperazine, CT1812, crenezumab, and CNP520. Though these drug candidates were enrolled in clinical trials, yet literature review shows many limitations. These limitations raise many questions on the rationale behind the enrollments of these drug candidates in clinical trials. A meticulous prior assessment of the outcome of clinical studies may stop risky clinical trials at their inceptions. This may save time, money, and resources.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"31-44"},"PeriodicalIF":0.0,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140140320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Dr. Google to CE-marked medical devices: need for ethical and legal safeguards. 从 "谷歌博士 "到获得 CE 认证的医疗器械：道德和法律保障的必要性。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2024-03-15 eCollection Date: 2024-01-01 DOI: 10.1515/jbcpp-2024-0020

Mariagrazia Marisei, Enrico Sicignano, Biagio Barone, Felice Crocetto, Luigi Napolitano

引用次数: 0

High-intensity combination exercise has the highest effect on increasing serum irisin and interleukin 6 levels in women with obesity. 高强度综合运动对提高肥胖妇女血清鸢尾素和白细胞介素 6 水平的效果最好。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2024-03-15 eCollection Date: 2024-01-01 DOI: 10.1515/jbcpp-2023-0150

Uswatun Hasanah, Purwo Sri Rejeki, Citrawati Dyah Kencono Wungu, Adi Pranoto, Nabilah Izzatunnisa, Ilham Rahmanto, Shariff Halim

{"title":"High-intensity combination exercise has the highest effect on increasing serum irisin and interleukin 6 levels in women with obesity.","authors":"Uswatun Hasanah, Purwo Sri Rejeki, Citrawati Dyah Kencono Wungu, Adi Pranoto, Nabilah Izzatunnisa, Ilham Rahmanto, Shariff Halim","doi":"10.1515/jbcpp-2023-0150","DOIUrl":"10.1515/jbcpp-2023-0150","url":null,"abstract":"Objectives: Lifestyle, overnutrition, socioeconomic status, environmental conditions, and genetics are factors that cause obesity. Lifestyle modification with a nonpharmacological approach based on physical exercise is the starting point in overcoming obesity. However, physical exercise with the appropriate and effective intensity for obese subjects is still debated. Therefore, this study aims to prove the effect of intensity differences with aerobic-resistance combination exercise on increasing irisin and IL-6 levels in obese women.Methods: A total of 32 obese women were selected as subjects and administered the interventions of low-intensity combination exercise (Q2), moderate-intensity combination exercise (Q3), and high-intensity combination exercise (Q4). ELISA was used to measure irisin and IL-6 levels in all samples. Statistical analysis used one-way ANOVA and Turkey's-Honest Significant Difference (HSD) post hoc test.Results: The mean Δ IL-6 levels in the control groups (Q1), Q2, Q3, and Q4 were 0.27 ± 2.54, 2.07 ± 2.55, 5.99 ± 6.25, and 7.98 ± 2.82 pg/mL with (p=0.015). The mean Δ irisin levels were 0.06 ± 0.81 ng/mL in Q1, 0.59 ± 0.67 ng/mL in Q2, 1.99 ± 1.65 ng/mL in Q3, 4.63 ± 3.57 ng/mL in Q4 with (p=0.001).Conclusions: This study proved that all three types of combined exercise intensity increased myokine levels, such as irisin and IL-6. However, high-intensity combination exercise provided the most optimal improvement in myokine levels in obese women. Future studies are needed to design long-term exercise programs specifically for obese adolescent women using the findings from this study.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"71-78"},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140119618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0