Journal of Basic and Clinical Physiology and Pharmacology最新文献_第5页

Early aggressive treatment with DMARDs vs. step-up therapy in rheumatoid arthritis: a traditional review of joint damage and functional outcomes. 类风湿性关节炎早期积极治疗DMARDs vs.强化治疗：关节损伤和功能结局的传统回顾

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-12-25 eCollection Date: 2026-03-01 DOI: 10.1515/jbcpp-2025-0060

Amruth Akhil Alluri, Aditya Rajesh Pawar, Shrishti Prakash Khetan, Rohan Singhal, Shruti Suresh Suvarna, Mehal Ravindra Adsure, Swathi N L

{"title":"Early aggressive treatment with DMARDs vs. step-up therapy in rheumatoid arthritis: a traditional review of joint damage and functional outcomes.","authors":"Amruth Akhil Alluri, Aditya Rajesh Pawar, Shrishti Prakash Khetan, Rohan Singhal, Shruti Suresh Suvarna, Mehal Ravindra Adsure, Swathi N L","doi":"10.1515/jbcpp-2025-0060","DOIUrl":"10.1515/jbcpp-2025-0060","url":null,"abstract":"Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by progressive joint inflammation and structural damage. Two primary treatment strategies - step-up therapy and early aggressive DMARD therapy have been widely debated in clinical practice. The step-up approach begins with NSAIDs or corticosteroids, progressing to DMARDs based on disease severity, whereas early aggressive therapy prioritizes immediate DMARD initiation to prevent irreversible joint damage. This comprehensive review evaluates the effectiveness of these strategies by analyzing randomized controlled trials (RCTs), meta-analyses, and cohort studies assessing treatment outcomes, remission rates, and radiographic progression. A literature search was conducted across PubMed, Scopus, and Web of Science, including studies published between 2010 and 2024. Key clinical trials, including TICORA, COBRA, BeSt, and CAMERA, were critically analyzed to assess the comparative benefits and limitations of both treatment approaches. Evidence suggests that early aggressive therapy is associated with higher remission rates, reduced radiographic progression, and improved long-term physical function, whereas the step-up approach often leads to delayed disease control and cumulative joint damage. However, concerns related to treatment adherence, cost-effectiveness, and safety profiles necessitate further investigation. Future research should focus on biomarker-driven personalized treatment strategies, optimizing drug sequencing, and long-term comparative effectiveness studies to refine RA management.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"71-93"},"PeriodicalIF":0.0,"publicationDate":"2025-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A retrospective observational study to evaluate the association between self-reported binge alcohol drinkers and asthma. 一项回顾性观察性研究，评估自我报告的酗酒者与哮喘之间的关系。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-12-24 eCollection Date: 2026-01-01 DOI: 10.1515/jbcpp-2025-0057

Yashaswi Guntupalli, Bharath Sai Vejandla, Shruti Suresh Suvarna, Shrishti Prakash Khetan, Jesheen Mann, Rhea Sibal, Deepthi Enumula

{"title":"A retrospective observational study to evaluate the association between self-reported binge alcohol drinkers and asthma.","authors":"Yashaswi Guntupalli, Bharath Sai Vejandla, Shruti Suresh Suvarna, Shrishti Prakash Khetan, Jesheen Mann, Rhea Sibal, Deepthi Enumula","doi":"10.1515/jbcpp-2025-0057","DOIUrl":"10.1515/jbcpp-2025-0057","url":null,"abstract":"Objectives: To assess the association between binge drinking and asthma risk across demographic and socioeconomic groups.Methods: A retrospective analysis using the 2022 Behavioral Risk Factor Surveillance System (BRFSS) database. Binge drinking status was the exposure variable, and asthma diagnosis was the outcome. Socioeconomic and demographic characteristics were included as covariates. Cross-tabulations, chi-squared tests, and Fisher's exact tests were conducted, results reported as odds ratios (ORs) and 95 % confidence intervals (CIs).Results: Binge drinkers had a 5.2 % lower asthma risk (OR: 0.948, 95 % CI: 0.9245-0.9722). The greatest risk reduction was in ages 45-64 (26.8 %), while ages 18-24 had a 14.3 % increased risk (OR: 1.143). Men had 4.4 % higher asthma risk, while women had 1.1 % lower risk. Black and Hispanic binge drinkers had 8.1 and 2.3 % higher risk, while white binge drinkers had 8.4 % lower risk. Higher-income and education were linked to lower asthma risk.Conclusions: Binge drinking is associated with lower asthma risk in older adults and women but higher risk in young adults and men. Further research is needed to explore mechanisms.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"51-56"},"PeriodicalIF":0.0,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145809348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A prospective study to assess the prognosis of patients with necrotizing fasciitis using laboratory risk indicator for necrotizing fasciitis (LRINEC) scoring system in a tertiary care hospital. 应用实验室坏死性筋膜炎风险指标（LRINEC）评分系统评估某三级医院坏死性筋膜炎患者预后的前瞻性研究。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-12-17 eCollection Date: 2026-03-01 DOI: 10.1515/jbcpp-2025-0117

Rekha Walwekar, Vignesh Ramalingam, Arun Walwekar

{"title":"A prospective study to assess the prognosis of patients with necrotizing fasciitis using laboratory risk indicator for necrotizing fasciitis (LRINEC) scoring system in a tertiary care hospital.","authors":"Rekha Walwekar, Vignesh Ramalingam, Arun Walwekar","doi":"10.1515/jbcpp-2025-0117","DOIUrl":"10.1515/jbcpp-2025-0117","url":null,"abstract":"Introduction: Necrotizing fasciitis (NF) is a rare but potentially fatal infection, involving the subcutaneous tissue and fascia. The incidence of NF worldwide ranges from 0.30 to 15 cases per 100,000 populations and mortality remains high at 25 %.Objectives: To classify severity of necrotizing fasciitis and assess the prognosis of necrotizing fasciitis using the LRINEC Scoring system.Methods: A thorough history and detailed clinical examination was done. Patient underwent necessary investigations like hemoglobulin, total leukocyte count, serum sodium, serum creatinine, random blood sugar, and C-reactive protein. Based on the investigations, two groups were formulated, LRINEC score <6 (low risk) and ≥6 (high risk). Then prognosis was assessed. The results were compared between the two groups.Results: In our study, a total of 124 patients were included with 62 of them with LRINEC score of <6 and 62 patients with LRINEC score ≥6. The sensitivity and specificity for predicting the septic shock and mortality with LRINEC score is 94 % and 70 % and 94 % and 71 %, respectively.Conclusions: LRINEC score is a simple clinical tool for predicting the prognostic outcomes in patients with necrotizing fasciitis. LRINEC score of ≥6 have poorer prognosis in the form septic shock and eventual mortality.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"133-138"},"PeriodicalIF":0.0,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145762930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and safety of Mirikizumab in the treatment of moderate to severe active ulcerative colitis: a systematic review. Mirikizumab治疗中重度活动性溃疡性结肠炎的疗效和安全性：一项系统综述。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-12-15 eCollection Date: 2026-03-01 DOI: 10.1515/jbcpp-2025-0172

Ajay Kumar Shukla, Saurav Misra, Ravi Kant Narayan, Shahnawaz Ahmed

{"title":"Efficacy and safety of Mirikizumab in the treatment of moderate to severe active ulcerative colitis: a systematic review.","authors":"Ajay Kumar Shukla, Saurav Misra, Ravi Kant Narayan, Shahnawaz Ahmed","doi":"10.1515/jbcpp-2025-0172","DOIUrl":"10.1515/jbcpp-2025-0172","url":null,"abstract":"Introduction: Ulcerative colitis in the second or third decade is characterised by haematochezia, stomach pain, faecal urgency, and tenesmus. On October 26, 2023, the US-FDA approved Mirikizumab for the treatment of moderate-to-severe ulcerative colitis in adults.Content: This systematic review evaluated the safety and effectiveness of Mirikizumab for the treatment of ulcerative colitis by analysing data from available clinical trials. We performed a thorough search across databases such as PubMed, Cochrane, Embase, Scopus, Google Scholar, and ClinicalTrials.gov, covering records from their inception up to June 30, 2025, in accordance with PRISMA guidelines. Thorough investigation identified five relevant studies: four randomised controlled trials and one observational study. All Mirikizumab doses achieved complete healing of the inflamed lumen. Except for the 50 mg dose, they also showed superior histological remission compared to placebo. Most adverse effects likely stem from the condition itself rather than the drug, supported by a higher dropout rate among placebo patients. Additionally, in patients with prior treatment failures, Mirikizumab demonstrated improved outcomes by week 40.Summary and outcome: Mirikizumab improves clinical, endoscopic, and histological results in ulcerative colitis. This study highlights the clinical importance of Mirikizumab and its potential to change treatment standards for ulcerative colitis.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"95-104"},"PeriodicalIF":0.0,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145742987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An overview and comparison of haemovigilance reporting forms across six countries relative to the WHO template. 与世卫组织模板相比，六个国家血液警戒报告表格的概述和比较。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-12-11 eCollection Date: 2026-03-01 DOI: 10.1515/jbcpp-2025-0120

Manmeet Kaur, Saurav Misra, Jayant Kumar Kairi

{"title":"An overview and comparison of haemovigilance reporting forms across six countries relative to the WHO template.","authors":"Manmeet Kaur, Saurav Misra, Jayant Kumar Kairi","doi":"10.1515/jbcpp-2025-0120","DOIUrl":"10.1515/jbcpp-2025-0120","url":null,"abstract":"Objectives: Haemovigilance monitors, identifies, reports, investigates, and analyses adverse event near-misses and reactions related to transfusion and blood product manufacture.Methods: This was an observational study in which we analyzed and compared the WHO haemovigilance template form for hospital and blood establishment haemovigilance reporting forms from Australia, Canada, India, New Zealand, South Africa, and the United States. All data from these reporting systems/forms was tabulated. The study analyzed data elements from each form, scoring them based on their presence in the WHO template and country forms. Higher scores indicated greater comparability and more comprehensive data collection.Results: We identified 57 data fields in haemovigilance reporting forms from six countries and the WHO template, essential for collecting information on suspected transfusion products and reactions. The US FDA form has the most fields at 40 (70 %), followed by Canada with 33 (58 %) and India with 27 (47 %). New Zealand's form has the fewest at 16 (28 %), followed by South Africa with 17 (30 %).Conclusions: Effective haemovigilance systems require time and commitment to develop, often starting small and growing with stakeholder involvement. A straightforward reporting form, accessible to all, is crucial for success.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"139-146"},"PeriodicalIF":0.0,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145714635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interleukin-23 (IL-23) inhibitor, mirikizumab in the treatment of ulcerative colitis (UC): a promising therapy? 白细胞介素-23 （IL-23）抑制剂米利珠单抗治疗溃疡性结肠炎（UC）：一个有希望的治疗方法？

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-11-27 eCollection Date: 2026-01-01 DOI: 10.1515/jbcpp-2024-0102

Saurav Misra, Manmeet Kaur, Ashish Kumar Saranjhna

{"title":"Interleukin-23 (IL-23) inhibitor, mirikizumab in the treatment of ulcerative colitis (UC): a promising therapy?","authors":"Saurav Misra, Manmeet Kaur, Ashish Kumar Saranjhna","doi":"10.1515/jbcpp-2024-0102","DOIUrl":"10.1515/jbcpp-2024-0102","url":null,"abstract":"Mirikizumab is a monoclonal antibody that targets the human IL-23p19 and has been humanized with IgG4. It is currently under development for treating Crohn's disease and ulcerative colitis. The FDA approved mirikizumab on October 26, 2023 as a highly effective treatment for ulcerative colitis, providing patients with a new option for this chronic and debilitating inflammatory bowel disease. Millions of people worldwide suffer from ulcerative colitis, and it is crucial to induce and maintain remission. However, existing therapies may not suffice in terms of efficacy or patient tolerability. Mirikizumab demonstrated a favorable safety profile during trials, with reported adverse events aligning with anticipated outcomes in the patient group. These safety results underscore the viability of mirikizumab as a well-tolerated therapeutic option for extended use. The trials data indicated that the treatment not only swiftly alleviated symptoms but also exhibited potential for sustaining remission over an extended period. This article seeks to offer a condensed overview of the noteworthy clinical trial outcomes that contributed to the development of mirikizumab, ultimately leading to its initial approval for the treatment of ulcerative colitis.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"25-31"},"PeriodicalIF":0.0,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145604405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of the urinary microbiome in diabetes-associated UTIs: current understanding and future directions. 尿微生物组在糖尿病相关尿路感染中的作用：目前的认识和未来的方向。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-11-19 eCollection Date: 2026-01-01 DOI: 10.1515/jbcpp-2025-0116

Meenakshi Reddy Yathindra, Rithvika Badugu, Shaurya Kumar Singh, Sowthrisha Paluri, Hrudai Poudala, Naraginti Leninbabu Swathi

{"title":"The role of the urinary microbiome in diabetes-associated UTIs: current understanding and future directions.","authors":"Meenakshi Reddy Yathindra, Rithvika Badugu, Shaurya Kumar Singh, Sowthrisha Paluri, Hrudai Poudala, Naraginti Leninbabu Swathi","doi":"10.1515/jbcpp-2025-0116","DOIUrl":"10.1515/jbcpp-2025-0116","url":null,"abstract":"This review explores the interplay between type 2 diabetes mellitus (T2DM) and urinary microbiome dysbiosis, focusing on its role in urinary tract infections (UTIs). Once considered sterile, the urinary tract hosts a diverse microbiota that supports mucosal immunity and pathogen resistance. In T2DM, chronic hyperglycemia and glycosuria disrupt microbial balance, impair immune responses, and increase UTI susceptibility. Glycosuria promotes pathogenic colonization, biofilm formation, and microbial shifts, with studies reporting a threefold rise in Escherichia coli and a 56 % reduction in Lactobacillus spp. in diabetic women with recurrent UTIs. Diabetic urine shows reduced diversity, higher abundance of Klebsiella, Pseudomonas, and Enterococcus, and elevated IL-8. Microbiota-targeted interventions, including probiotics (Lactobacillus crispatus, Lactobacillus rhamnosus GR-1), prebiotics (astaxanthin), and phytotherapeutics (cranberry), demonstrate potential via lactic acid, hydrogen peroxide production, competitive exclusion, and NF-κB modulation. A 12-month RCT showed significant UTI recurrence reduction with probiotics. Advances in 16 S rRNA sequencing and metagenomics reveal microbial signatures associated with diabetic UTIs, though methodological heterogeneity limits comparability. A review of 1,200 publications (2000-2024) highlights the need for longitudinal studies and precision microbiota therapeutics to translate findings into clinical practice.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"9-24"},"PeriodicalIF":0.0,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145540971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thyroid hormone imbalance, malnutrition, and sarcopenia: a triad of muscle health challenges. 甲状腺激素失衡，营养不良和肌肉减少症：肌肉健康的三重挑战。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-11-17 eCollection Date: 2025-11-01 DOI: 10.1515/jbcpp-2025-0160

Annarita Nappi, Serena Sagliocchi, Annunziata Gaetana Cicatiello, Caterina Miro

{"title":"Thyroid hormone imbalance, malnutrition, and sarcopenia: a triad of muscle health challenges.","authors":"Annarita Nappi, Serena Sagliocchi, Annunziata Gaetana Cicatiello, Caterina Miro","doi":"10.1515/jbcpp-2025-0160","DOIUrl":"10.1515/jbcpp-2025-0160","url":null,"abstract":"Sarcopenia and malnutrition are increasingly recognized as major determinants of morbidity and functional decline in aging and chronically ill populations. Thyroid hormones (THs), particularly triiodothyronine (T3), play a critical role in regulating skeletal muscle homeostasis, influencing myogenesis, mitochondrial function, metabolic rate, and fibre-type specification. Alterations in thyroid function, both hypo- and hyperthyroidism, negatively impact muscle protein turnover, leading to impaired strength and muscle wasting. Notably, nutritional status modulates TH metabolism at multiple levels: malnutrition impairs deiodinase activity, alters TH transport, and reduces peripheral T3 availability, thereby contributing to the low T3 syndrome frequently observed in frail or undernourished individuals. Conversely, excessive T3 levels, as seen in hyperthyroid states or during inappropriate replacement therapy, exacerbate catabolism and accelerate muscle loss. This review synthesizes current evidence on the bidirectional interactions among thyroid dysfunction, nutritional deficiencies, and sarcopenia, proposing an integrative pathophysiological model. We discuss the clinical implications of TH replacement in sarcopenic and malnourished patients, highlighting the need for personalised, multimodal interventions that include hormonal, nutritional, and physical strategies to prevent or mitigate muscle deterioration in endocrine and geriatric contexts.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"351-357"},"PeriodicalIF":0.0,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145512906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Menopause, estrogen, and GERD: an exploration of symptoms and endoscopic correlations. 更年期，雌激素和胃反流：症状和内镜相关性的探索。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-10-16 eCollection Date: 2026-01-01 DOI: 10.1515/jbcpp-2025-0097

Praveena Meyyazhagan, Pavitra Vyshnavi Yogisparan, Thendral Anandaraj

{"title":"Menopause, estrogen, and GERD: an exploration of symptoms and endoscopic correlations.","authors":"Praveena Meyyazhagan, Pavitra Vyshnavi Yogisparan, Thendral Anandaraj","doi":"10.1515/jbcpp-2025-0097","DOIUrl":"10.1515/jbcpp-2025-0097","url":null,"abstract":"Objectives: To define the pattern of symptoms and severity of GERD among premenopausal and postmenopausal women in relation to estrogen levels and endoscopy findings.Methods: The research was carried out in the Laboratory of Gastrointestinal Motility inside the Gastroenterology Department at PSGIMS&R, Coimbatore and the following approval from Institutional Human Ethics Committee (IHEC).Results: The findings reveal significant variations in estrogen levels between premenopausal and postmenopausal women with gastroesophageal reflux disease (GERD), with premenopausal women having higher levels (82.80 ± 27.91 to 150.43 ± 40.80 pg/mL) compared to postmenopausal women (6.05 ± 2.75 to 17.30 ± 5.43 pg/mL, p < 0.001). This decline in estrogen post-menopause is associated with increased GERD symptoms and endoscopic abnormalities.Conclusion: The study concludes that reduced estrogen levels in postmenopausal women are linked to a higher prevalence of GERD symptoms, including heartburn and dysphagia, compared to premenopausal women. Endoscopic findings further support the correlation between hormonal changes and GERD severity, highlighting the necessity for careful evaluation of GERD risk factors.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"33-44"},"PeriodicalIF":0.0,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of adiponectin and nutritional indices with sarcopenia in elderly diabetic patients. 脂联素和营养指标与老年糖尿病患者肌肉减少症的关系。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-10-16 eCollection Date: 2025-11-01 DOI: 10.1515/jbcpp-2025-0128

Aruna Raju, Jean Fredrick, Asmita Hazra, Boudhayan Das Munshi, Debarati Guha Roy

{"title":"Association of adiponectin and nutritional indices with sarcopenia in elderly diabetic patients.","authors":"Aruna Raju, Jean Fredrick, Asmita Hazra, Boudhayan Das Munshi, Debarati Guha Roy","doi":"10.1515/jbcpp-2025-0128","DOIUrl":"10.1515/jbcpp-2025-0128","url":null,"abstract":"Objectives: To assess the relationship between adiponectin levels, nutritional indices, and sarcopenia in elderly diabetic patients, and to identify metabolic and nutritional biomarkers that distinguish sarcopenic from non-sarcopenic elderly diabetic individuals.Methods: This cross-sectional study included 80 diabetic patients aged >60 years, sarcopenic (n=40) and non-sarcopenic (n=40) groups based on Asian Working Group for Sarcopenia criteria. Serum adiponectin, glucose metabolism markers, lipid profiles, and nutritional indices including prognostic nutritional index (PNI), geriatric nutritional risk index (GNRI), and controlling nutritional status (CONUT) score were assessed.Results: Sarcopenic patients demonstrated significantly higher adiponectin levels (12.8 ± 3.4 vs. 8.4 ± 2.1 μg/mL, p<0.001), representing a 52% increase compared to non-sarcopenic individuals. The sarcopenic group showed impaired insulin sensitivity (QUICKI: 0.31 ± 0.05 vs. 0.36 ± 0.04, p=0.003), elevated atherogenic indices, and reduced nutritional status. All nutritional indices were significantly impaired in the sarcopenic group: PNI (45.2 ± 5.4 vs. 52.4 ± 6.8, p<0.001), GNRI, and CONUT score. Multiple logistic regression identified adiponectin (OR=1.264, 95% CI: 1.062-1.504, p=0.009), age, insulin resistance, and nutritional indices as independent predictors of sarcopenia.Conclusions: Elevated adiponectin levels paradoxically associate with sarcopenia in elderly diabetes, suggesting a potential biomarker for muscle wasting. The association between nutritional indices and sarcopenia emphasizes the importance of comprehensive nutritional assessment in elderly diabetic patients.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"365-372"},"PeriodicalIF":0.0,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0