Journal of Basic and Clinical Physiology and Pharmacology最新文献

Atrioventricular block and myastenia gravis. A case report and review of the literature. 房室传导阻滞与重症肌无力。病例报告及文献回顾。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-10-01 DOI: 10.1515/jbcpp-2025-0155

Anna Lombardi, Francesco Murru, Luigi Giuseppe Atripaldi, Carmine D'Argenzio, Rita Verdoliva, Giordana G Iannibelli, Claudia Canitano, Mariarosaria De Luca, Giuseppe Cudemo, Rosa Lucci, Andrea Salzano, Alberto M Marra, Michele Arcopinto, Antonio Cittadini

{"title":"Atrioventricular block and myastenia gravis. A case report and review of the literature.","authors":"Anna Lombardi, Francesco Murru, Luigi Giuseppe Atripaldi, Carmine D'Argenzio, Rita Verdoliva, Giordana G Iannibelli, Claudia Canitano, Mariarosaria De Luca, Giuseppe Cudemo, Rosa Lucci, Andrea Salzano, Alberto M Marra, Michele Arcopinto, Antonio Cittadini","doi":"10.1515/jbcpp-2025-0155","DOIUrl":"https://doi.org/10.1515/jbcpp-2025-0155","url":null,"abstract":"Objectives: Myasthenia gravis (MG) is a chronic autoimmune disease primarily affecting skeletal muscles, though cardiac involvement, particularly arrhythmias, may occur, especially in severe cases or in patients with thymoma.Case presentation: We report the case of a 62-year-old male with AchR-Ab-positive MG, without thymoma, who developed an advanced atrioventricular block requiring pacemaker implantation. Cardiac manifestations in MG can result from either the disease itself - through myocarditis, autoantibodies and autonomic dysfunction - or as a side effect of treatments such as pyridostigmine and immunosuppressants. Management strategies include considering discontinuation of pyridostigmine or using hyoscyamine to assess potential drug-induced bradyarrhythmias before proceeding with permanent pacing.Conclusions: This case highlights the diagnostic challenges in distinguishing iatrogenic from autoimmune cardiac complications and emphasizes the importance of cardiovascular monitoring in MG patients, especially those presenting with cardiac symptoms or EKG abnormalities. Early recognition and appropriate intervention are crucial to improve outcomes and quality of life.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mental toughness and athletic performance: a narrative review. 心理韧性与运动表现：一种叙事回顾。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-09-25 DOI: 10.1515/jbcpp-2025-0091

Raja Soundara Pandian Pachaiappan, Veera Balajikumar Veeraswamy, Kannan Mahalingam, Gurubharathy Gurusamy, Bijulakshmi Parthiban

{"title":"Mental toughness and athletic performance: a narrative review.","authors":"Raja Soundara Pandian Pachaiappan, Veera Balajikumar Veeraswamy, Kannan Mahalingam, Gurubharathy Gurusamy, Bijulakshmi Parthiban","doi":"10.1515/jbcpp-2025-0091","DOIUrl":"https://doi.org/10.1515/jbcpp-2025-0091","url":null,"abstract":"Background: Mental toughness represents a crucial psychological construct in competitive sports. This narrative review examines the relationship between mental toughness and athletic performance across various sports domains.Methods: We conducted a comprehensive literature review of empirical studies published between 2000 and 2024. Relevant articles were identified through database searches including PubMed, PsycINFO, SPORTDiscus, and Web of Science. Studies examining mental toughness in relation to performance outcomes in competitive athletes were included.Results: Evidence consistently shows positive correlations between mental toughness and athletic performance (r=0.21-0.63). Mental toughness demonstrates stronger associations with performance in individual sports compared to team sports. Additionally, psychological interventions targeting mental toughness components show promise for enhancing athletic outcomes.Conclusions: Mental toughness represents a significant psychological factor in athletic achievement. The construct influences performance through multiple pathways including resilience to pressure, emotional regulation, and focus maintenance. Practical applications for coaches and sport psychologists are discussed.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of polypharmacy and appropriateness of prescription in geriatric patients using Beer's criteria at tertiary care hospital: a record based retrospective study. 利用Beer标准评价三级医院老年患者的多药及处方适宜性：一项基于记录的回顾性研究。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-09-18 DOI: 10.1515/jbcpp-2024-0099

Geetanjali Hiremath, Radhika Sherkhane, Shrikant Hiremath

{"title":"Evaluation of polypharmacy and appropriateness of prescription in geriatric patients using Beer's criteria at tertiary care hospital: a record based retrospective study.","authors":"Geetanjali Hiremath, Radhika Sherkhane, Shrikant Hiremath","doi":"10.1515/jbcpp-2024-0099","DOIUrl":"https://doi.org/10.1515/jbcpp-2024-0099","url":null,"abstract":"Objectives: The current study aims to evaluate the aptness of prescription in elderly along with looking out for polypharmacy, overprescribing and under prescribing in geriatric patients being treated at the tertiary care hospital.Methods: This is a retrospective record-based study, data was collected from 1st January 2017 to 31st December 2018 of all the patient which are falling in the inclusion criteria. Prescription appropriateness was assessed implementing 'Beers criteria'. Errors in prescription along with administration were checked by direct observation and analysis of prescriptions.Results: Out of total 2,718 patients, 58.6 % were found to be males and 41.4 % were females. Most common comorbidities found were hypertension and coronary artery diseases (CAD). In the current study, 39 % of the prescription contained inappropriate medication and 11.20 % prescriptions were having adverse drug reaction. Error by attending nurse in prescription reading came out to be the most common error in this study.Conclusions: Diclofenac was found to be the most commonly used inappropriate drug as per Beer's criteria. Clinicians should be more cautious when using drugs in old age patients.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A cross-sectional observational study of the prevalence and characterization of potential QT-prolonging drug‒drug interactions in oncological outpatients. 肿瘤门诊患者中潜在延长qt的药物-药物相互作用的患病率和特征的横断面观察研究。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-08-12 DOI: 10.1515/jbcpp-2024-0104

Akash Agnihotri, Biswadeep Das, Sachin Manocha, Manjunath Bidarolli, Bharati Vashisht

{"title":"A cross-sectional observational study of the prevalence and characterization of potential QT-prolonging drug‒drug interactions in oncological outpatients.","authors":"Akash Agnihotri, Biswadeep Das, Sachin Manocha, Manjunath Bidarolli, Bharati Vashisht","doi":"10.1515/jbcpp-2024-0104","DOIUrl":"https://doi.org/10.1515/jbcpp-2024-0104","url":null,"abstract":"Objectives: This study aims to assess the prevalence, characteristics, and risk factors of potential QT-prolonging drug-drug interactions (pQT-DDIs) in cancer patients, including identifying drug combinations contributing to QT prolongation and key predictors.Methods: In this hospital-based, cross-sectional observational study, all types of cancer patients, irrespective of age or sex, were included over 1 year. pQT-DDIs were identified using four drug interaction checker software tools. Predictors were analyzed using univariate logistic regression.Results: A total of 1,331 cancer patients were included. The prevalence of pQT-DDIs was 67.6 %. Of these, 606 (45.5 %) had 1-2 pQT-DDIs, 126 (9.5 %) had 3-4, and 78 (5.9 %) had 5-6. Overall, 163 drug combinations were identified as causing QT prolongation; 122 were detected by Drugs.com. Significant predictors included >8 drugs prescribed (OR=6.46; CI=4.87-8.56; p<0.0001), >2 anticancer drugs (OR=1.68; CI=1.14-2.46; p=0.008), >6 adjuvant drugs (OR=6.83; CI=5.17-9.03; p<0.0001), solid cancers (OR=6.59; CI=4.59-8.80; p<0.0001), and cytotoxic drug use (OR=2.40; CI=1.52-3.77; p=0.0001).Conclusions: There is a high prevalence of pQT-DDIs in cancer patients. Those receiving multiple anticancer and adjuvant drugs are at higher risk. Routine interaction screening is recommended before chemotherapy.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144816786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on the molecular aspect of cardioprotective effects of selenium: a mini-review. 硒对心脏保护作用的分子机制研究综述。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-08-01 DOI: 10.1515/jbcpp-2024-0128

Neda Roshanravan, Samad Ghaffari, Majid Mosharkesh, Rezayat Parvizi, Shamsi Ghaffari, Erfan Mosharkesh, Ahmad Separham

引用次数: 0

The current pathogenicity and potential risk evaluation of Ebola virus to cause mysterious disease X - An update on recent evidences. 目前埃博拉病毒引起神秘疾病X的致病性和潜在风险评价——最新证据。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-07-22 DOI: 10.1515/jbcpp-2023-0240

Abir Hasan Pranto, Md Rabiul Islam

引用次数: 0

Efficacy and safety of retatrutide for the treatment of obesity: a systematic review of clinical trials. 利特鲁肽治疗肥胖的有效性和安全性：临床试验的系统回顾。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-07-21 eCollection Date: 2025-07-01 DOI: 10.1515/jbcpp-2025-0113

Saurav Misra, Ravi Kant Narayan, Manmeet Kaur

{"title":"Efficacy and safety of retatrutide for the treatment of obesity: a systematic review of clinical trials.","authors":"Saurav Misra, Ravi Kant Narayan, Manmeet Kaur","doi":"10.1515/jbcpp-2025-0113","DOIUrl":"10.1515/jbcpp-2025-0113","url":null,"abstract":"Introduction: Obesity is a major public health issue linked to various health complications. Retatrutide, a triple agonist peptide targeting the glucagon receptor, GIP receptor, and GLP-1 receptor, shows promise in addressing this need.Content: This systematic review assessed the safety and efficacy of retatrutide for obesity treatment using available clinical trial data. We conducted a comprehensive search of databases, including PubMed, Cochrane and ClinicalTrials.gov, from their inception until March 15, 2025 following PRISMA guidelines.Summary: Three articles were included in this systematic review, screening a total of 1,082 patients, with 691 randomly assigned to groups. The average age of participants was 54.26 ± 9.9 years, consisting of 335 men (48 %) and 356 women (52 %). Retatrutide was administered to 510 participants, while 130 received a placebo. The 12 mg dosage of retatrutide showed the most significant reductions in body weight, body mass index, and waist circumference. It also led to a higher percentage of patients achieving weight losses of ≥5 , 10, 15, and 20 %. Gastrointestinal adverse effects were the most commonly reported.Outlook: Weekly subcutaneous injections of retatrutide in obese patients resulted in significant weight loss and metabolic improvements compared to a placebo.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":"36 4","pages":"263-274"},"PeriodicalIF":0.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term retention of diabetes management skills in type 1 diabetic patients trained with advanced technologies. 1型糖尿病患者接受先进技术培训后糖尿病管理技能的长期保留。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-07-17 DOI: 10.1515/jbcpp-2025-0115

Michele R Modestino, Rita Verdoliva, Umberto De Fortuna, Laura Ferrentino, Olimpia Iacono, Giuseppe Memoli, Francesca Nappi, Domenico La Sala, Ilaria Ciullo, Angelo Foglia, Vincenzo Guardasole

{"title":"Long-term retention of diabetes management skills in type 1 diabetic patients trained with advanced technologies.","authors":"Michele R Modestino, Rita Verdoliva, Umberto De Fortuna, Laura Ferrentino, Olimpia Iacono, Giuseppe Memoli, Francesca Nappi, Domenico La Sala, Ilaria Ciullo, Angelo Foglia, Vincenzo Guardasole","doi":"10.1515/jbcpp-2025-0115","DOIUrl":"https://doi.org/10.1515/jbcpp-2025-0115","url":null,"abstract":"Objectives: The effectiveness of diabetes management depends significantly on patients' knowledge of key concepts such as carbohydrate counting, bolus timing, duration of insulin action, and the interpretation of trend arrows. This study aims to evaluate the understanding of these concepts among patients with type 1 diabetes who are using advanced technologies.Methods: From January 2024 to July 2024, consecutive patients with type 1 diabetes who met inclusion criteria were enrolled. Participants were asked to complete a questionnaire to assess their retention of key concepts for T1D management. Each patient completed the questionnaire independently in a private room before their medical appointment.Results: This study evaluated therapeutic education in adult T1D patients in Campania, Italy, who use advanced diabetes technologies. Despite most patients having long-term diabetes, significant knowledge gaps were found in diabetes management. Only 40 % of CGM users correctly correlated sensor data with capillary glucose, and 19 % erroneously believed they were identical. Just 25 % patients knew their insulin-to-carbohydrate ratio, and only 56 % accurately calculated carbohydrates. Even among users of advanced hybrid closed-loop systems, similar deficiencies existed.Conclusions: Understanding of key concepts necessary for effective management of diabetes using advanced technologies remains insufficient in a cohort of Italian patients.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A critical comparison of pharmacovigilance reporting forms in six countries with the WHO-UMC recommendations (form of the form). 对6个国家的药物警戒报告表格与世卫组织-联合药检委员会的建议进行关键性比较（表格的形式）。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-07-17 eCollection Date: 2025-07-01 DOI: 10.1515/jbcpp-2025-0084

Saurav Misra, Manmeet Kaur, Jayant Kumar Kairi

{"title":"A critical comparison of pharmacovigilance reporting forms in six countries with the WHO-UMC recommendations (form of the form).","authors":"Saurav Misra, Manmeet Kaur, Jayant Kumar Kairi","doi":"10.1515/jbcpp-2025-0084","DOIUrl":"10.1515/jbcpp-2025-0084","url":null,"abstract":"Objectives: This study will identify strengths and weaknesses of ADR reporting forms of study countries.Methods: This was an observational study conducted at the Department of Pharmacology at Kalpana Chawla Government Medical College, Karnal. We obtained the WHO-UMC adverse event reporting guidance document for designing the ADR form for member countries. We similarly collected and analysed ADR forms from Australia, Canada, India, South Africa, the UK, and the US. Data fields were grouped into different subgroups.Results: An analysis of ADR reporting forms from six countries revealed a total of 70 data fields. The US-FDA's FORM 3500 has the most fields at 50 (71 %), followed by India's CDSCO with 42 fields (60 %). According to WHO-UMC recommendations, Canada and Australia have the highest number of suggested fields at 10 (83 %). All forms were one page long except for the US-FDA's, which is five pages.Conclusions: Improving patient feedback and organisational engagement is essential to raise awareness of the reporting system. A proposed generic ADR form provides detailed information for causality assessment and could serve as a basis for a standard global reporting form.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"285-294"},"PeriodicalIF":0.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic potential of resveratrol: novel biological and pharmacological perspectives. 白藜芦醇的治疗潜力：新的生物学和药理学观点。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-07-11 DOI: 10.1515/jbcpp-2024-0211

Milad Ashrafizadeh

{"title":"Therapeutic potential of resveratrol: novel biological and pharmacological perspectives.","authors":"Milad Ashrafizadeh","doi":"10.1515/jbcpp-2024-0211","DOIUrl":"https://doi.org/10.1515/jbcpp-2024-0211","url":null,"abstract":"The application of natural occurring compounds in the treatment of human diseases has been increased in the recent decades due to the biocompatibility and pleiotropic impacts of these agents along with significant health-promoting effects. Among them, resveratrol has been shown to be of importance, since it can exert various biological and pharmacological activities. Moreover, resveratrol generally demonstrates good biosafety and biocompatibility that can further improve its application in clinical studies. In terms of biological activities, the antioxidant and anti-inflammatory activities of resveratrol has been of importance and they are useful in the prevention of diabetes and neurological diseases. The antioxidant activity of resveratrol can result from its function in enhancing levels of antioxidant factors such as catalase and superoxide dismutase, and reduction in ROS levels. Moreover, resveratrol can reduce inflammation and downregulate related pathways such as NF-κB. Beyond this, resveratrol has been shown to be beneficial in the treatment of human diseases such as diabetes mellitus, cancer (suppressing tumorigenesis or acting as chemopreventive agent) and alleviation of neurological diseases, among others. Such protective impacts of resveratrol would be discussed in the current review with a focus on underlying molecular factors. In addition, nanoparticles have been significantly applied in the treatment of human disease through delivery of resveratrol and since pharmacokinetic profile of resveratrol is poor, the application of delivery systems can accelerate therapeutic index of this natural product. However, clinical application of resveratrol-loaded nanoparticles in the clinical level relies on the biocomaptibility and safety of these structures along with their efficacy.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0