Journal of Basic and Clinical Physiology and Pharmacology最新文献

Impact of an oral amino acid-containing formulation on clinical and functional outcomes in patients with and without heart failure undergoing cardiac rehabilitation program: a pilot study. 口服含氨基酸制剂对接受心脏康复计划的有或无心力衰竭患者临床和功能结果的影响：一项初步研究。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2026-09-24 DOI: 10.1515/jbcpp-2026-0221

Ermanno Nardi, Regina Sorrentino, Elenagaia Ziello, Flavia Lanzilli, Mario Mallardo

{"title":"Impact of an oral amino acid-containing formulation on clinical and functional outcomes in patients with and without heart failure undergoing cardiac rehabilitation program: a pilot study.","authors":"Ermanno Nardi, Regina Sorrentino, Elenagaia Ziello, Flavia Lanzilli, Mario Mallardo","doi":"10.1515/jbcpp-2026-0221","DOIUrl":"https://doi.org/10.1515/jbcpp-2026-0221","url":null,"abstract":"Objectives: Skeletal muscle dysfunction and malnutrition are common in patients with cardiovascular disease (CVD), particularly those with heart failure (HF), and may reduce the benefits of cardiac rehabilitation (CR). Amino acid supplementation may enhance exercise-induced adaptations, but evidence during CR remains limited.Methods: We conducted a pilot study including 25 patients with CVD, of whom 13 (52 %) had HF, undergoing a 3-month CR program with oral amino acid-containing nutritional formulation. Clinical and nutritional status, quality of life, psychological well-being, physical performance, exercise capacity, laboratory findings, and echocardiographic parameters were assessed at baseline and after 3 months.Results: Significant improvements were observed in NYHA class, Mini Nutritional Assessment-Short Form, Minnesota Living with Heart Failure Questionnaire, Hospital Anxiety and Depression Scale, and Short Physical Performance Battery (all p<0.05). Exercise capacity improved, with a mean increase of 59.4 m in the 6-min walk test (p<0.001) and lower Borg scores (p=0.003). NT-proBNP levels decreased (p=0.023). Left ventricular ejection fraction remained unchanged, whereas global longitudinal strain and left atrial volume index improved (p≤0.007).Conclusions: Oral amino acid-containing supplementation combined with CR was associated with improved functional capacity, nutritional status, quality of life, and favorable changes in LV myocardial deformation. Larger randomized trials are needed to confirm these findings and determine the incremental contribution of this nutritional formulation.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149024964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

To eat, or not to eat… dietary patterns and the clinical recognition of insulinoma: a case report. 吃还是不吃……饮食模式与胰岛素瘤的临床认识：1例报告。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2026-09-17 eCollection Date: 2026-09-01 DOI: 10.1515/jbcpp-2026-0193

Lorenzo Timpani, Luisa De Rosa, Michele Arcopinto, Giuseppe Cudemo, Umberto De Fortuna, Mariarosaria De Luca, Luigi De Vito, Anna Lombardi, Rosa Lucci, Andrea Salzano, Abdulrahman Alsergani, Raffaele Napoli, Vincenzo Guardasole, Antonio Cittadini

{"title":"To eat, or not to eat… dietary patterns and the clinical recognition of insulinoma: a case report.","authors":"Lorenzo Timpani, Luisa De Rosa, Michele Arcopinto, Giuseppe Cudemo, Umberto De Fortuna, Mariarosaria De Luca, Luigi De Vito, Anna Lombardi, Rosa Lucci, Andrea Salzano, Abdulrahman Alsergani, Raffaele Napoli, Vincenzo Guardasole, Antonio Cittadini","doi":"10.1515/jbcpp-2026-0193","DOIUrl":"10.1515/jbcpp-2026-0193","url":null,"abstract":"Objectives: Insulinoma is a rare pancreatic neuroendocrine tumor causing endogenous hyperinsulinemic hypoglycemia. Its heterogeneous clinical presentation often delays diagnosis. Dietary patterns, particularly ketogenic or high-carbohydrate regimens, may influence glucose homeostasis and modify the clinical manifestations of insulinoma.Case presentation: A 70-year-old woman was admitted with recurrent documented hypoglycemia. She reported a 10-year history of seizure-like episodes and intermittent neurological symptoms that began after starting a ketogenic diet. Symptoms later became less frequent during a high-calorie, carbohydrate-rich diet but recurred after adopting a Mediterranean diet. Biochemical evaluation confirmed endogenous hyperinsulinemic hypoglycemia. A supervised fasting test documented symptomatic hypoglycemia with plasma glucose of 17 mg/dL, fulfilling Whipple's triad. Magnetic resonance imaging revealed a 4 cm pancreatic tail lesion, and ˆ68 Ga-DOTATATE PET/CT showed intense uptake consistent with a somatostatin receptor-positive neuroendocrine tumor. As the patient declined surgery, diazoxide and dietary modifications were started, improving symptoms and glycemic control.Conclusions: This case suggests that dietary habits may influence the clinical presentation of insulinoma. Marked carbohydrate restriction may unmask hypoglycemia, whereas high-carbohydrate intake may attenuate symptoms and contribute to delayed diagnosis. Careful assessment of dietary habits should be part of the evaluation of patients with recurrent unexplained hypoglycemia suggestive of insulinoma.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"447-452"},"PeriodicalIF":0.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148976963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbiome and atherosclerosis: hype or future therapeutic target? 微生物组与动脉粥样硬化：炒作还是未来的治疗目标？

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2026-09-16 DOI: 10.1515/jbcpp-2025-0190

Zoya Hussain, Madhuri Gali, Dhruvilkumar Patel, Amritha Suresh Kumar, Akkshaya Suresh Kumar, Akash Ranganatha, N L Swathi

{"title":"Microbiome and atherosclerosis: hype or future therapeutic target?","authors":"Zoya Hussain, Madhuri Gali, Dhruvilkumar Patel, Amritha Suresh Kumar, Akkshaya Suresh Kumar, Akash Ranganatha, N L Swathi","doi":"10.1515/jbcpp-2025-0190","DOIUrl":"https://doi.org/10.1515/jbcpp-2025-0190","url":null,"abstract":"From 2010 to 2025, evidence increasingly identifies the gut microbiome, microbial dysbiosis, trimethylamine-N-oxide (TMAO), and short-chain fatty acids (SCFAs) as modulators of atherosclerosis and cardiovascular disease. We conducted a narrative review of literature retrieved from PubMed, Scopus, and the Clinical Trials Registry-India (CTRI), covering studies published between January 2010 and March 2025. A total of 103 primary studies (animal, n=15; human cohort, n=28; mechanistic, n=22; randomized controlled trials, n=38) and 10 ongoing clinical trials were reviewed. Germ-free and antibiotic-treated murine models support a role for TMA-producing microbial communities in plaque formation, whereas SCFA-producing communities attenuate inflammation and atherogenesis. In humans, elevated TMAO levels are associated with a 2-5-fold higher risk of major adverse cardiovascular events (MACE), although causal inference remains limited. Probiotics, synbiotics, dietary interventions, and fecal microbiota transplantation may improve TMAO, LDL cholesterol, and inflammatory markers, but definitive reductions in cardiovascular events have not been demonstrated. Overall, microbiome-targeted strategies remain promising but require large, diverse clinical trials to establish causality and clinical benefit.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148968624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective and restorative effects of hexarelin on MPTP-induced lung injury in mice. hexarelin对mptp诱导的小鼠肺损伤的保护和恢复作用。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2026-08-21 DOI: 10.1515/jbcpp-2026-0178

Onur Celikoglu, Elif S Karanfil, Ozlem Ozmen

{"title":"Protective and restorative effects of hexarelin on MPTP-induced lung injury in mice.","authors":"Onur Celikoglu, Elif S Karanfil, Ozlem Ozmen","doi":"10.1515/jbcpp-2026-0178","DOIUrl":"https://doi.org/10.1515/jbcpp-2026-0178","url":null,"abstract":"Objectives: This study investigated the protective and therapeutic effects of hexarelin (HEX) against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced lung injury in mice by evaluating oxidative stress, IL-6-mediated inflammation, and Caspase-3-dependent apoptosis.Methods: Fifty male Balb/C mice were randomly assigned to five groups (n=10): control, MPTP, PREHEX, POSTHEX, and HEX. Parkinson-like neurotoxicity was induced by a single intranasal dose of MPTP (1 mg/kg). Hexarelin (10 μg/kg, i.p.) was administered twice at 4-h intervals before or after MPTP exposure. Lung tissues were examined histopathologically using hematoxylin-eosin staining, and immunohistochemically for Caspase-3, IL-6, and SOD expression.Results: MPTP caused severe pulmonary injury, including alveolar wall thickening, edema, hyperemia, and inflammatory infiltration, with increased Caspase-3 (p<0.001) and IL-6 (p=0.002) expression and reduced SOD immunoreactivity compared with controls (p<0.001). Both HEX regimens significantly reduced histopathological damage and improved immunohistochemical parameters (p<0.05). POSTHEX showed greater recovery than PREHEX, with lower apoptotic (p=0.005) and inflammatory (p=0.050) marker expression and higher SOD (p=0.007) levels. The enhanced efficacy of therapeutic post-treatment over prophylactic pretreatment is likely attributable to the active engagement of cytoprotective pathways during ongoing severe oxidative and inflammatory cascades, optimizing hexarelin's receptor-mediated cellular rescue mechanisms.Conclusions: Hexarelin demonstrated significant protective and therapeutic effects against MPTP-induced lung injury by mitigating oxidative stress, suppressing inflammation, and limiting apoptosis.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A recent update on luteolin: mechanisms and therapeutic implications in cardiac disease. 木犀草素的最新进展：心脏疾病的机制和治疗意义。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2026-08-17 Print Date: 2026-09-25 DOI: 10.1515/jbcpp-2026-0104

Aysha Javed, Tarique Mahmood, Farogh Ahsan, Aimen Salman, Amrita Shukla, Mohammad Shariq, Abdul Baseer Khan

{"title":"A recent update on luteolin: mechanisms and therapeutic implications in cardiac disease.","authors":"Aysha Javed, Tarique Mahmood, Farogh Ahsan, Aimen Salman, Amrita Shukla, Mohammad Shariq, Abdul Baseer Khan","doi":"10.1515/jbcpp-2026-0104","DOIUrl":"10.1515/jbcpp-2026-0104","url":null,"abstract":"To evaluate the cardioprotective effects of luteolin, a naturally occurring flavonoid, in mitigating critical pathological processes linked to cardiovascular diseases (CVDs), including oxidative stress, inflammation, mitochondrial dysfunction, and endothelial damage. Luteolin, found in celery, parsley, green peppers, and chamomile tea, exhibits significant cardioprotective properties through various mechanisms. It activates the Nrf2/HO-1 antioxidant pathway, suppresses NF-κB-mediated inflammation, regulates apoptosis, and preserves the functionality of endothelial nitric oxide synthase (eNOS). In preclinical studies involving isoproterenol- and doxorubicin-induced cardiotoxicity, luteolin was shown to reduce oxidative stress, decrease apoptosis, and improve cardiac structure and function. Compared to other flavonoids like quercetin and resveratrol, luteolin demonstrates more potent endothelial-protective effects and a balanced modulation of antioxidant and apoptotic pathways. The diverse actions and natural origin of luteolin make it a promising candidate for CVD prevention and as an adjunctive therapy. Future research should focus on rigorously designed clinical trials to validate its efficacy in heart failure, ischemic injury, and drug-induced cardiotoxicity, thus enhancing its application in clinical practice.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"361-379"},"PeriodicalIF":0.0,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148758338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obstetric pharmacogenomics. 产科药物基因组学。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2026-08-11 eCollection Date: 2026-09-01 DOI: 10.1515/jbcpp-2026-0183

Ahizechukwu Chigoziem Eke

{"title":"Obstetric pharmacogenomics.","authors":"Ahizechukwu Chigoziem Eke","doi":"10.1515/jbcpp-2026-0183","DOIUrl":"10.1515/jbcpp-2026-0183","url":null,"abstract":"Pregnancy profoundly alters drug disposition through dynamic physiologic adaptations affecting absorption, distribution, metabolism, and excretion. Although pharmacogenomics has transformed precision therapeutics across multiple medical specialties, its application during pregnancy remains limited because conventional pharmacogenomic models assume stable genotype-phenotype relationships that do not account for the temporal biologic changes of gestation. This mini-review proposes a conceptual framework for obstetric-pharmacogenomics in which maternal, placental, and fetal-genomes interact within a continuously evolving physiologic environment to shape drug exposure, therapeutic efficacy, and toxicity. Pregnancy-induced alterations in cytochrome P450 enzyme activity, drug transporters, placental metabolism, and immune regulation may amplify, attenuate, or fundamentally modify genetically determined drug responses, rendering static pharmacogenomic classifications insufficient. We discuss the clinical implications of this dynamic paradigm across several therapeutic areas, including antiretroviral therapy, maternal mental health, hypertensive disorders of pregnancy, and analgesia, and highlight the need for trimester-specific approaches to individualized drug therapy. We further examine current barriers to implementation, including the exclusion of pregnant women from pharmacogenomic research, limited longitudinal data, and ethical considerations surrounding fetal genetics. Integrating pharmacogenomics with physiologically based pharmacokinetic modeling and multi-omics technologies offers an opportunity to redefine precision-medicine in obstetrics and advance safer, more effective, and individualized pharmacotherapy for pregnant-women and their offspring.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"355-360"},"PeriodicalIF":0.0,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13524412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148700855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incisional hernia repair in cirrhotic patients with ascites: a multicenter retrospective experience. 肝硬化腹水患者切口疝修补：一项多中心回顾性研究。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2026-08-05 DOI: 10.1515/jbcpp-2026-0173

Agostino Fernicola, Pierluigi Angelini, Luigi Ricciardelli, Alfonso Santangelo, Domenico Santangelo, Murtaja Satea Shafeea, Felice Crocetto, Armando Calogero, Vincenzo Schiavone, Giacomo Benassai, Gennaro Quarto, Gianluca Costa, Marco Caricato, Michele Santangelo

{"title":"Incisional hernia repair in cirrhotic patients with ascites: a multicenter retrospective experience.","authors":"Agostino Fernicola, Pierluigi Angelini, Luigi Ricciardelli, Alfonso Santangelo, Domenico Santangelo, Murtaja Satea Shafeea, Felice Crocetto, Armando Calogero, Vincenzo Schiavone, Giacomo Benassai, Gennaro Quarto, Gianluca Costa, Marco Caricato, Michele Santangelo","doi":"10.1515/jbcpp-2026-0173","DOIUrl":"https://doi.org/10.1515/jbcpp-2026-0173","url":null,"abstract":"Objectives: Incisional hernia is a complication after abdominal surgery and is particularly challenging in patients with ascites because of increased intra-abdominal pressure, impaired wound healing, and infection risk. Evidence on surgical repair remains limited, particularly for incisional rather than umbilical hernias.Methods: This retrospective multicenter study included 31 cirrhotic patients with ascites (22 males, 9 females; 45-72 years) who underwent incisional hernia repair between 2000 and 2025 at three tertiary General and Emergency Surgery Units. Liver disease severity was assessed using the Child-Pugh classification. Following preoperative ascites optimization, repair was performed with primary suture or mesh reinforcement. Primary outcomes were perioperative morbidity and mortality; secondary outcome was hernia recurrence.Results: Perioperative mortality occurred in 5 patients (16.1 %), all with advanced liver disease. Major complications occurred in 8 patients (25.8 %), while minor complications developed in 10 (32.3 %), mainly surgical site infection, seroma or hematoma, and postoperative ileus. After a median follow-up of 26 months, hernia recurrence occurred in 11 patients (35.5 %) and was higher after primary suture than mesh repair.Conclusions: Elective repair is feasible in selected patients after ascites optimization. Mesh reinforcement provides greater durability when infection risk is acceptable. Patient selection and perioperative management remain essential.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148669862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High frequency of sperm function defects in normozoospermic infertile men. 正常精子不育男性精子功能缺陷发生率高。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2026-07-21 DOI: 10.1515/jbcpp-2026-0101

Vertika Singh, Arijit Chakraborty, Sameer Trivedi

{"title":"High frequency of sperm function defects in normozoospermic infertile men.","authors":"Vertika Singh, Arijit Chakraborty, Sameer Trivedi","doi":"10.1515/jbcpp-2026-0101","DOIUrl":"https://doi.org/10.1515/jbcpp-2026-0101","url":null,"abstract":"Objectives: Conventional semen analysis often fails to detect hidden functional defects contributing to male infertility. Factors such as sperm DNA-integrity, oxidative stress, MMP, and acrosome integrity are critical for fertilization and early embryonic development. This study aimed to evaluate sperm function defects in normozoospermic infertile men and highlight limitations of routine semen parameters in infertility assessment.Methods: Semen samples underwent standard semen analysis. Sperm DNA damage was assessed using Acridine Orange staining, acrosome integrity by FITC-PSA staining, and ROS levels along with MMP were measured using flow cytometry. Appropriate statistical analyses were performed to compare infertile men and fertile controls and determine correlations among functional parameters.Results: Among clinically screened infertile patients, 23 % were normozoospermic according to WHO 2010 criteria. Sperm function parameters were evaluated in normozoospermic infertile men (n=45) and fertile controls (n=17). Infertile men exhibited significantly higher ROS levels and DNA damage (p<0.001), alongside reduced acrosome integrity and MMP (p<0.001) compared to controls. ROS showed a positive correlation with DNA damage and acrosome-reacted sperm, and a negative correlation with MMP.Conclusions: Functional sperm defects may underlie infertility in a substantial proportion of normozoospermic men. Incorporating sperm function tests as second-line investigations may improve diagnosis and management of unexplained male infertility.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148520385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Appropriateness of prescribing in elderly patients attending a tertiary care teaching hospital according to STOPP-START criteria. 根据stop - start标准在三级护理教学医院就诊的老年患者处方的适当性。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2026-07-17 eCollection Date: 2026-09-01 DOI: 10.1515/jbcpp-2026-0040

Sushmita Mukherjee Banerjee, Shreya Shah

{"title":"Appropriateness of prescribing in elderly patients attending a tertiary care teaching hospital according to STOPP-START criteria.","authors":"Sushmita Mukherjee Banerjee, Shreya Shah","doi":"10.1515/jbcpp-2026-0040","DOIUrl":"10.1515/jbcpp-2026-0040","url":null,"abstract":"Objectives: To determine the frequency and pattern of potentially inappropriate prescriptions, including potentially inappropriate medications (PIMs) and potential prescribing omissions (PPOs), among elderly inpatients aged 65 years and above in a tertiary care hospital.Methods: This hospital-based observational Cross-sectional study was conducted from January 2019 to January 2020 in the Medicine Department. Four hundred patients aged ≥65 years with at least one chronic illness and complete medication records were included. The STOPP/START version 2 criteria were applied to identify PIMs and PPOs. Demographic details, clinical diagnoses, and hospitalization data were collected and analyzed.Results: Among 400 patients (233 men, 167 women; mean age 69 ± 4.94 years), cardiovascular diseases were the most common cause of admission (30 %), followed by respiratory (21 %) and nervous system disorders (12.5 %). A total of 4,337 medications were prescribed, averaging 10.87 per patient. PIMs were identified in 48 patients (12 %), most frequently cardiovascular drugs (36 %), fall-risk-increasing drugs (16 %), and antiplatelet/anticoagulant agents (13 %). PPOs were observed in 38 patients (9.5 %), commonly involving cardiovascular and preventive therapies.Conclusions: Inappropriate prescribing remains prevalent among elderly inpatients. Routine use of structured tools such as STOPP/START may enhance safer, evidence-based prescribing and improve outcomes.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"417-424"},"PeriodicalIF":0.0,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148470844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting the AGE-RAGE/GSK-3β axis in diabetic retinopathy: wound-healing effects of trans-anethole and FPS-ZM1 and putative GSK-3β inhibitory activity of FPS-ZM1. 针对糖尿病视网膜病变的AGE-RAGE/GSK-3β轴：反式茴酚和FPS-ZM1的伤口愈合作用以及FPS-ZM1的GSK-3β抑制活性

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2026-07-14 DOI: 10.1515/jbcpp-2026-0145

Deniz Irem Caglayaner, Zeynep Arslantas, Fatih Kemaloğlu, Sefer Baday, Belkis Atasever-Arslan

{"title":"Targeting the AGE-RAGE/GSK-3β axis in diabetic retinopathy: wound-healing effects of trans-anethole and FPS-ZM1 and putative GSK-3β inhibitory activity of FPS-ZM1.","authors":"Deniz Irem Caglayaner, Zeynep Arslantas, Fatih Kemaloğlu, Sefer Baday, Belkis Atasever-Arslan","doi":"10.1515/jbcpp-2026-0145","DOIUrl":"https://doi.org/10.1515/jbcpp-2026-0145","url":null,"abstract":"Objectives: Diabetic retinopathy (DR) causes retinal detachment, capillary degeneration, and diabetic macular edema. Chronic hyperglycemia leads to the formation of advanced glycation end products (AGEs). This activates the receptor for advanced glycation end-products (RAGE) signaling pathway, resulting in inflammation, oxidative stress, and cellular issues in the retina. The AGE-RAGE axis and signaling pathways are attractive therapeutic targets.Methods: This study investigated the protective effects of trans-anethole (TA) and the RAGE inhibitor FPS-ZM1 in an in vitro model of high glucose-induced retinal injury. Both compounds were initially evaluated by molecular docking against GSK-3β. As FPS-ZM1 demonstrated higher predicted binding affinity than TA, further computational analyses, including molecular dynamics simulations and MM/GBSA binding free energy calculations, were performed only for FPS-ZM1.Results: Both only TA and its combination with FPS-ZM1 greatly improved the healing response when glucose levels were high. This suggests that TA may have considerable therapeutic potential for wound healing. In addition, molecular docking and molecular dynamics simulations revealed that FPS-ZM1 may interact with GSK-3β ligand binding site.Conclusions: Further investigations utilizing in vivo models are necessary to validate the inhibitory impact of FPS-ZM1 on GSK-3β and to elucidate the molecular mechanisms responsible for the protective benefits of trans-anethole.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148436771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0