Journal of Basic and Clinical Physiology and Pharmacology最新文献

Quality by design: how poor adherence to guidelines holds back urological app innovation.

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2024-12-13 DOI: 10.1515/jbcpp-2024-0205

Emanuele Capasso, Mariagrazia Marisei, Ferdinando Fusco, Enrico Sicignano, Felice Crocetto

引用次数: 0

A cross-sectional study on the effects of physical activity on hand grip strength in type 2 diabetes mellitus patients. 关于体育锻炼对 2 型糖尿病患者手部握力影响的横断面研究。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2024-11-28 DOI: 10.1515/jbcpp-2024-0176

Praveena M, K ThamaraiSelvi, Nachal Annamalai

{"title":"A cross-sectional study on the effects of physical activity on hand grip strength in type 2 diabetes mellitus patients.","authors":"Praveena M, K ThamaraiSelvi, Nachal Annamalai","doi":"10.1515/jbcpp-2024-0176","DOIUrl":"https://doi.org/10.1515/jbcpp-2024-0176","url":null,"abstract":"Objectives: The pervasiveness of type 2 diabetes mellitus (T2DM) is rapidly increasing worldwide, with physical inactivity being one of the major risk factors. Hand grip strength (HGS) is an important indicator of overall physical functioning and has been associated with various health-related outcomes. The purpose of this study was to investigate the impact of physical activity on the HGS of patients with type 2 diabetes mellitus (T2DM). Furthermore, it scrutinizes the relationship between physical activity and HGS in terms of sex.Methods: A cross-sectional study including a total of 140 patients with T2DM was performed. Physical activity levels were assessed via the International Physical Activity Questionnaire (IPAQ). HGS was measured via a Camry digital handgrip dynamometer. Statistical analysis was performed via SPSS software, and statistical approaches such as ANOVA, Pearson correlation and t tests were used.Results: The results of this research will contribute to the detection of the influence of physical activity and its association with HGS. These findings reveal that physical activity has a significant effect on HGS and that there is a positive correlation between physical activity and increased hand grip strength in individuals with T2DM.Conclusions: The outcomes offer valuable insights into physical activity and muscle strength, which can aid in the early detection of physical disability. The findings of this study will be valuable for healthcare providers and professionals to suggest relevant physical activities for diabetic patients.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to: 6-OHDA mediated neurotoxicity in SH-SY5Y cellular model of Parkinson disease suppressed by pretreatment with hesperidin through activating L-type calcium channels. 更正：在帕金森病 SH-SY5Y 细胞模型中使用橙皮甙预处理可通过激活 L 型钙通道抑制 6-OHDA 介导的神经毒性。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2024-11-18 eCollection Date: 2024-11-01 DOI: 10.1515/jbcpp-2024-0122

Leila Elyasi, Mehrdad Jahanshahi, S B Jameie, Hatef Ghasemi Hamid Abadi, Emsehgol Nikmahzar, Masoumeh Khalili, Melika Jameie, Mana Jameie

引用次数: 0

Effect of omega-3 fatty acids supplementation on muscle mass, fat mass, and visceral fat of hemodialysis patients; A randomized clinical trial. 补充欧米伽-3 脂肪酸对血液透析患者肌肉质量、脂肪质量和内脏脂肪的影响；随机临床试验。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2024-11-14 Print Date: 2024-11-26 DOI: 10.1515/jbcpp-2024-0148

Saheb Abbas Torki, Zahra Roumi, Atefeh Tahavorgar, Zahra Salimi, Saeideh Mohammadi, Soheila Shekari, Zahra Saeedirad, Arezoo Amjadi, Pouya Mirzaee, Hanieh Shafaei, Bojlul Bahar, Fatemeh Mofidi, Masoud Khosravi, Saeid Doaei, Maryam Gholamalizadeh

{"title":"Effect of omega-3 fatty acids supplementation on muscle mass, fat mass, and visceral fat of hemodialysis patients; A randomized clinical trial.","authors":"Saheb Abbas Torki, Zahra Roumi, Atefeh Tahavorgar, Zahra Salimi, Saeideh Mohammadi, Soheila Shekari, Zahra Saeedirad, Arezoo Amjadi, Pouya Mirzaee, Hanieh Shafaei, Bojlul Bahar, Fatemeh Mofidi, Masoud Khosravi, Saeid Doaei, Maryam Gholamalizadeh","doi":"10.1515/jbcpp-2024-0148","DOIUrl":"10.1515/jbcpp-2024-0148","url":null,"abstract":"Objectives: Several studies demonstrated the benefits of omega-3 fatty acids supplementation in chronic kidney disease (CKD) patients. The objective of this study was to investigate the effect of omega-3 fatty acids supplementation in body composition, specifically on the lean body mass and fat mass in hemodialysis patients.Methods: In this randomized, double-blind, placebo-controlled clinical trial, a total of 120 end-stage renal disease (ESRD) patients were randomly allocated into two groups. The intervention group has taken three grams of omega-3 fatty acids daily while the placebo group received three grams of medium chain triglycerides (MCT) as a placebo for a total of 2 months. The changes in the body mass index (BMI) and body composition (fat mass, muscle, and visceral fat) were assessed at baseline and following the intervention.Results: No significant difference was found in the mean of BMI, FAT, muscle, and visceral fat in the intervention group compared to the control group after the intervention. After two months of omega-3 fatty acid supplementation, the study found no statistically significant impact of omega-3 fatty acids supplementation on various indices of body composition. The effect of ω-3 supplementation in reducing visceral fat was close to significant (p=0.08).Conclusions: This study suggests that there is currently inadequate evidence to support the effect of omega-3 fatty acid supplementation in improving anthropometric measurements in patients with CKD, except a partial effect on visceral fat. Further large-scale and long-term clinical trials are needed to confirm the present results.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"347-352"},"PeriodicalIF":0.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immediate effect of sunlight exposure through blue glass on blood pressure in hypertensive patients: a randomized controlled trial. 通过蓝色玻璃照射阳光对高血压患者血压的直接影响：随机对照试验。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2024-11-13 eCollection Date: 2024-11-01 DOI: 10.1515/jbcpp-2024-0081

Deepa Yoganathan, Maheshkumar Kuppusamy, Edmin Christa, Saran Murugan, Vijayabharathi Elangovan, Preetha Jayakumar, Sangamithraa Rammohan

{"title":"Immediate effect of sunlight exposure through blue glass on blood pressure in hypertensive patients: a randomized controlled trial.","authors":"Deepa Yoganathan, Maheshkumar Kuppusamy, Edmin Christa, Saran Murugan, Vijayabharathi Elangovan, Preetha Jayakumar, Sangamithraa Rammohan","doi":"10.1515/jbcpp-2024-0081","DOIUrl":"10.1515/jbcpp-2024-0081","url":null,"abstract":"Objective: Hypertension affects approximately 1.28 billion adults worldwide, driving the search for integrative therapeutic approaches alongside conventional treatments. While chromotherapy, particularly blue light exposure, has historical roots in traditional medicine and its specific impact on blood pressure regulation remains understudied. So, the present study aims to investigate the immediate impact of exposure to blue glass through sunlight on blood pressure in hypertensive individuals.Methods: This randomized controlled trial was carried out with a sample of 60 hypertensive patients, who were divided into two groups: a study group that received blue glass exposure for 20 min and a control group that received exposure to colourless glass. The primary outcome measures were systolic and diastolic blood pressure, pulse rate, and oxygen saturation levels.Results: The results of the study revealed statistically significant differences in systolic blood pressure (p=0.006) and pulse rate (p=0.005) after the intervention in the study group and no such changes were noted in the control group.Conclusions: The findings of this study suggest that blue glass exposure has a significant impact on reducing blood pressure and pulse rate in hypertensive patients, indicating its potential use as a integrative treatment in the management of hypertension.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"371-374"},"PeriodicalIF":0.0,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Choroidal and retinal alteration after long-term use of tadalafil: a prospective non-randomized clinical trial. 长期服用他达拉非后脉络膜和视网膜的改变：一项前瞻性非随机临床试验。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2024-11-13 eCollection Date: 2024-11-01 DOI: 10.1515/jbcpp-2024-0118

Luca D'Andrea, Gianluigi Califano, Marco Abate, Marco Capece, Claudia Collà Ruvolo, Felice Crocetto, Maria Laura Passaro, Gilda Cennamo, Ciro Costagliola

{"title":"Choroidal and retinal alteration after long-term use of tadalafil: a prospective non-randomized clinical trial.","authors":"Luca D'Andrea, Gianluigi Califano, Marco Abate, Marco Capece, Claudia Collà Ruvolo, Felice Crocetto, Maria Laura Passaro, Gilda Cennamo, Ciro Costagliola","doi":"10.1515/jbcpp-2024-0118","DOIUrl":"10.1515/jbcpp-2024-0118","url":null,"abstract":"Objectives: The purpose of this study is to investigate choroidal and retinal vascular features in patients taking PDE5is by measuring dynamic vascular alterations and neurostructural features of the retina before and after oral tadalafil administration.Methods: The current clinical research involved 22 patients treated with tadalafil 20 mg on alternate days (OAD) after nerve-sparing robotic radical prostatectomy (NS-RARP) for prostate cancer. Patients underwent SD-OCT to assess ganglion cell complex (GCC), retinal nerve fiber layer (RNFL), and subfoveal choroidal thickness (SFCT), as well as OCTA to assess superficial capillary plexus (SCP), deep capillary plexus (DCP), choriocapillaris (CC), foveal avascular zone (FAZ), and radial peripapillary capillary thickness (RPC). All patients were evaluated at baseline (t0), and 3 (t1) and 6 (t2) months after the use of oral tadalafil.Results: A statistically significant reduction in DCP and CC vessel density was found at t2 compared to baseline. According to the SFCT parameter, a statistically significant increase was observed from t0 to t1, and from t1 to t2. GCC parameter increased at t2 compared to baseline in a statistically significant way. No statistically significant differences were recorded between t0, t1 and t2 for the SCP, RPC, FAZ area, RNFL parameter.Conclusions: Retinal and optic disc toxicity may be detected using modifications of capillary vessel density. Further studies are needed to detect the possible progression or regression of ocular or systemic vascular complications in long-term follow-up.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"361-369"},"PeriodicalIF":0.0,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The alarming link between the COVID-19 pandemic and stroke: why ignoring this association after relapse of the disease has dangerous consequences. COVID-19 大流行与中风之间令人震惊的联系：为什么疾病复发后忽视这种联系会带来危险后果？

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2024-10-28 eCollection Date: 2024-11-01 DOI: 10.1515/jbcpp-2024-0179

Nader Aghakhani, Roya Naderi

引用次数: 0

Identification of ocular artifact in EEG signals using VMD and Hurst exponent. 利用 VMD 和 Hurst 指数识别脑电信号中的眼球伪影。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2024-10-24 Print Date: 2024-11-26 DOI: 10.1515/jbcpp-2024-0027

Amandeep Bisht, Preeti Singh, Pardeep Kaur, Geeta Dalal

{"title":"Identification of ocular artifact in EEG signals using VMD and Hurst exponent.","authors":"Amandeep Bisht, Preeti Singh, Pardeep Kaur, Geeta Dalal","doi":"10.1515/jbcpp-2024-0027","DOIUrl":"10.1515/jbcpp-2024-0027","url":null,"abstract":"Objectives: Electroencephalographic (EEG) readings are usually infected with unavoidable artifacts, especially physiological ones. One such physiological artifact is the ocular artifacts (OAs) that are generally related to eyes and are characterized by high magnitude and a specific spike pattern in the prefrontal region of the brain. During the long-duration EEG acquisition, the retrieval of important information becomes quite complicated in prefrontal regions as ocular artifacts dominate the EEG recorded, making it difficult to discern underlying brain activity.Methods: With the progress and development in signal processing techniques, artifact handling has become a progressive field of investigation. This paper presents a framework for the detection and correction of ocular artifacts. This study emphasizes improving the quality and reducing the time complexity by using higher-order statistics (HOS) for artifact identification and variational mode decomposition (VMD) for OA correction.Results: An overall SNR of 14 dB, MAE of 0.09, and PSNR of 33.59 dB has been attained by the proposed framework.Conclusions: It was observed that the proposed HOS-VMD surpassed the state-of-the-art mode decomposition techniques.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"353-359"},"PeriodicalIF":0.0,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The challenge of thigh tendon reinjuries: an expert opinion. 大腿肌腱再损伤的挑战：专家意见。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2024-10-24 eCollection Date: 2024-11-01 DOI: 10.1515/jbcpp-2024-0177

Stefano Palermi, Filippo Vittadini, Giulio Pasta, Marcello Zappia, Alessandro Corsini, Carles Pedret, Luca Vergani, Italo Leo, Gianni Nanni, Marco Vecchiato, Andrea Demeco, Immacolata Belviso, Felice Sirico, Aleksi Jokela, Lasse Lempainen

{"title":"The challenge of thigh tendon reinjuries: an expert opinion.","authors":"Stefano Palermi, Filippo Vittadini, Giulio Pasta, Marcello Zappia, Alessandro Corsini, Carles Pedret, Luca Vergani, Italo Leo, Gianni Nanni, Marco Vecchiato, Andrea Demeco, Immacolata Belviso, Felice Sirico, Aleksi Jokela, Lasse Lempainen","doi":"10.1515/jbcpp-2024-0177","DOIUrl":"10.1515/jbcpp-2024-0177","url":null,"abstract":"This review critically examines the issue of thigh tendon reinjury in athletes, drawing on recent advancements and diverse perspectives in sports medicine. The findings underscore the paramount importance of an early and accurate diagnosis, which significantly influences treatment efficacy and rehabilitation outcomes. We explore the intricacies of tendon anatomy and the mechanisms underlying injuries, highlighting how these factors interplay with athlete-specific risk profiles to affect reinjury rates. A major finding from the review is the necessity for individualized rehabilitation approaches that integrate both traditional methods and emerging technologies. These technologies show promise in enhancing monitoring and facilitating precise adjustments to rehabilitation protocols, thus improving recovery trajectories. Additionally, the review identifies a common shortfall in current practices - premature to play (RTP) - which often results from inadequate adherence to tailored rehabilitation strategies or underestimation of the injury's severity. Such premature RTP significantly heightens the risk of further injury. Through this synthesis of contemporary research and expert opinion, the review advocates for a multidisciplinary approach in managing thigh tendon injuries, emphasizing the need for ongoing research to refine RTP criteria and optimize rehabilitation techniques. The ultimate goal is to support athletes in achieving safer and more effective recoveries, thereby reducing the likelihood of tendon reinjury.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"335-345"},"PeriodicalIF":0.0,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bimagrumab: an investigational human monoclonal antibody against activin type II receptors for treating obesity. Bimagrumab：一种用于治疗肥胖症的针对活化素 II 型受体的在研人类单克隆抗体。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2024-10-10 eCollection Date: 2024-11-01 DOI: 10.1515/jbcpp-2024-0065

Manmeet Kaur, Saurav Misra

{"title":"Bimagrumab: an investigational human monoclonal antibody against activin type II receptors for treating obesity.","authors":"Manmeet Kaur, Saurav Misra","doi":"10.1515/jbcpp-2024-0065","DOIUrl":"10.1515/jbcpp-2024-0065","url":null,"abstract":"Bimagrumab is a human monoclonal antibody that prevents activin type II receptors (ActRII) from functioning. This antibody has a higher affinity for muscle activin-2 receptors than natural ligands such as activin and myostatin, which act as negative muscle growth regulators. Blocking the activin receptor with bimagrumab could be a new pharmaceutical approach for managing patients with obesity and type 2 diabetes mellitus (T2DM). Bimagrumab has anabolic effects on skeletal muscle mass by preventing myostatin binding and other negative muscle growth regulators. Preclinical animal models have also shown that ActRII blockade promotes actions beyond skeletal muscle, including effects on brown adipose tissue (BAT) differentiation and activity. In a phase 2 randomized clinical trial, ActRII blockade with bimagrumab led to significant loss of total body fat mass (FM), lean mass (LM) gain, and metabolic improvements over 48 weeks in overweight or obese patients with type 2 diabetes. The trial involved [number of participants], and the results showed [specific findings]. Currently, Bimagrumab is being evaluated for its potential to treat muscle wasting, functional loss in hip fractures and sarcopenia, as well as obesity. However, it is essential to note that Bimagrumab also blocks the effects of other ActRII ligands, which play a role in the neurohormonal axes, pituitary, gonads, and adrenal glands. These observations suggest that bimagrumab might represent a new approach for treating patients with obesity and related metabolic disturbances.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"325-334"},"PeriodicalIF":0.0,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142390888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0