Journal of Basic and Clinical Physiology and Pharmacology最新文献_第10页

Investigating periprostatic adipose tissue as a driving force of prostate cancer progression: a new source of information for the advancement of targeted therapy in metastatic prostate cancer. 研究作为前列腺癌进展驱动力的前列腺周围脂肪组织：促进转移性前列腺癌靶向治疗的新信息来源。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2023-03-27 eCollection Date: 2023-05-01 DOI: 10.1515/jbcpp-2023-0059

Evelina La Civita, Gianluigi Carbone, Enrico Sicignano, Felice Crocetto, Daniela Terracciano

引用次数: 0

Inguinal lymphadenectomy in penile cancer patients: a comparison between open and video endoscopic approach in a multicenter setting. 阴茎癌患者腹股沟淋巴结切除术：开放式和视频内窥镜方法在多中心环境中的比较。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2023-03-20 eCollection Date: 2023-05-01 DOI: 10.1515/jbcpp-2023-0038

Maida Bada, Felice Crocetto, Peter Nyirady, Vincenzo Pagliarulo, Sebastiano Rapisarda, Antonio Aliberti, Stefano Boccasile, Matteo Ferro, Biagio Barone, Antonio Celia

{"title":"Inguinal lymphadenectomy in penile cancer patients: a comparison between open and video endoscopic approach in a multicenter setting.","authors":"Maida Bada, Felice Crocetto, Peter Nyirady, Vincenzo Pagliarulo, Sebastiano Rapisarda, Antonio Aliberti, Stefano Boccasile, Matteo Ferro, Biagio Barone, Antonio Celia","doi":"10.1515/jbcpp-2023-0038","DOIUrl":"10.1515/jbcpp-2023-0038","url":null,"abstract":"Objectives: To compare differences of operative outcomes, post-operative complications and survival outcomes between open and laparoscopic cases in a multicenter study.Methods: This was a retrospective cohort study performed at three European centers from September 2011 to January 2019. The surgeon decision to perform open inguinal lymphadenectomy (OIL) or video endoscopic inguinal lymphadenectomy (VEIL) was done in each hospital after patient counselling. Inclusion criteria regarded a minimum follow-up of 9 months since the inguinal lymphadenectomy.Results: A total of 55 patients with proven squamous cell penile cancer underwent inguinal lymphadenectomy. 26 of them underwent OIL, while 29 patients underwent VEIL. For the OIL and VEIL groups, the mean operative time was 2.5 vs. 3.4 h (p=0.129), respectively. Hospital stays were lower in the VEIL group with 4 vs. 8 days in OIL patients (p=0.053) while number of days requiring drains to remain in situ was 3 vs. 6 days (p=0.024). The VEIL group reported a lower incidence of major complications compared to the OIL group (2 vs. 17%, p=0.0067) while minor complications were comparable in both groups. In a median follow-up period of 60 months, the overall survival was 65.5 and 84.6% in OIL and VEIL groups, respectively (p=0.105).Conclusions: VEIL is comparable to OIL regarding safety, overall survival and post-operative outcomes.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":"34 3","pages":"383-389"},"PeriodicalIF":0.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9843910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of tirzepatide on prediabetics and blood pressure with implications for future research. 替西肽对前驱糖尿病患者和血压的影响及其对未来研究的意义。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2023-03-01 DOI: 10.1515/jbcpp-2022-0305

Rajmohan Seetharaman

引用次数: 0

Antioxidant and anti-inflammatory effect of olive leaf extract treatment in diabetic rat brain. 橄榄叶提取物对糖尿病大鼠脑的抗氧化和抗炎作用。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2023-03-01 DOI: 10.1515/jbcpp-2021-0054

Mehmet Berköz, Tahir Kahraman, Zwain Nozad Shamsulddin, Mirosław Krośniak

{"title":"Antioxidant and anti-inflammatory effect of olive leaf extract treatment in diabetic rat brain.","authors":"Mehmet Berköz, Tahir Kahraman, Zwain Nozad Shamsulddin, Mirosław Krośniak","doi":"10.1515/jbcpp-2021-0054","DOIUrl":"https://doi.org/10.1515/jbcpp-2021-0054","url":null,"abstract":"Objectives: Olive (Olea europaea L.) plays a promising role in pharmaceutical, nutraceutical, and cosmetic production. On the other hand, olive leaf is widely used in folk medicine due to its antihyperglycemic activity. For this aim, possible effects of olive leaf extract (OLE) in the brain tissue of streptozotocin-induced diabetic rats were investigated.Methods: A total of 28 male rats were divided into four equal groups as control, diabetic (single dose of 45 mg/kg streptozotocin, i.p.), OLE (500 mg/kg/day), and diabetic + OLE groups. The study was terminated 21 days after the diabetes model was formed. At the end of the study, all the animals were sacrificed and blood and brain tissues were isolated. Relative brain weights, complete blood count, blood glycated hemoglobin, serum glucose, total protein, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, insulin, gonadal hormone levels, production and messenger ribonucleic acid (mRNA) levels of proinflammatory cytokines and mediators, total thiol, total oxidative stress, and total antioxidant status levels and fatty acid composition in brain tissue were measured in all study groups.Results: In diabetic rats, relative brain weight and serum insulin level decreased, glycated hemoglobin, oxidative stress, production and mRNA level of proinflammatory cytokines and mediators increased, hyperglycemia, hypercholesterolemia and hypertriglyceridemia, degraded fatty acid composition, anemia, leukopenia, and thrombocytopenia occurred. After OLE treatment, a remarkable improvement in most of these parameters, except gonadal hormones, has been observed in diabetic rats.Conclusions: This study suggests that olive leaf can be a precious neuroprotective agent in diabetes.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":"34 2","pages":"187-196"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9458820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Implication of nitrergic system in the anticonvulsant effects of ferulic acid in pentylenetetrazole-induced seizures in male mice. 氮能系统在阿魏酸对戊四唑致雄性小鼠癫痫发作的抗惊厥作用中的作用。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2023-03-01 DOI: 10.1515/jbcpp-2020-0496

Hossein Amini-Khoei, Shakiba Nasiri Boroujeni, Zahra Lorigooini, Arash Salehi, Reihaneh Sadeghian, Mohammad Rahimi-Madiseh

{"title":"Implication of nitrergic system in the anticonvulsant effects of ferulic acid in pentylenetetrazole-induced seizures in male mice.","authors":"Hossein Amini-Khoei, Shakiba Nasiri Boroujeni, Zahra Lorigooini, Arash Salehi, Reihaneh Sadeghian, Mohammad Rahimi-Madiseh","doi":"10.1515/jbcpp-2020-0496","DOIUrl":"https://doi.org/10.1515/jbcpp-2020-0496","url":null,"abstract":"Objectives: Seizures are abnormal discharge of neurons in the brain. Ferulic acid (FA) is a phenolic compound with antioxidant and neuroprotective effects. The present study aimed to investigate the role of the nitrergic system in the anticonvulsant effect of FA in pentylenetetrazol (PTZ)-induced seizures in male mice.Methods: 64 male Naval Medical Research Institute (NMRI) mice weighing 25-29 g were randomly divided into eight experimental groups (n=8). FA at doses 5, 10, and 40 mg/kg alone and in combination with L-nitro-arginine methyl ester (L-NAME) (nitric oxide synthase inhibitor) or L-arginine (L-arg) (nitric oxide [NO] precursor) was administrated (intraperitoneal). PTZ was injected (i.v. route) 30 min after drugs administration (1 mL/min). Seizure onset time was recorded and the nitrite levels of prefrontal cortex and serum were determined by the Griess method.Results: FA at doses of 10 and 40 mg/kg significantly increased the seizure threshold as well as reduced the serum and brain NO levels in comparison to the saline-received group. Co-administration of the effective dose of FA (10 mg/kg) plus L-arg significantly decreased the seizure threshold in comparison to the effective dose of FA alone. Co-injection of the sub-effective dose of FA (5 mg/kg) with L-NAME significantly increased the seizure threshold as well as significantly decreased the brain NO level in comparison to the sub-effective dose of FA alone.Conclusions: We showed that the nitrergic system, partially at least, mediated the anticonvulsant effect of FA in PTZ-induced seizures in mice. We concluded that L-NAME potentiated while L-arg attenuated the anticonvulsant effect of FA.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":"34 2","pages":"197-203"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9113720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review on pulmonary and mediastinal synovial sarcoma. 肺和纵隔滑膜肉瘤的研究进展。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2023-03-01 DOI: 10.1515/jbcpp-2022-0286

Kristin Purnama Dewi, Ivana Purnama Dewi, Iswanto Iswanto, Laksmi Wulandari

引用次数: 0

Effects of weight-bearing vs. non-weight-bearing endurance exercise on reducing body fat and inflammatory markers in obese females. 负重与非负重耐力运动对肥胖女性减少体脂和炎症标志物的影响

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2023-03-01 DOI: 10.1515/jbcpp-2022-0158

Olivia Andiana, Wilda Welis, Muhamad Syamsul Taufik, Widiastuti, Abdul Hakim Siregar, Slamet Raharjo

{"title":"Effects of weight-bearing vs. non-weight-bearing endurance exercise on reducing body fat and inflammatory markers in obese females.","authors":"Olivia Andiana, Wilda Welis, Muhamad Syamsul Taufik, Widiastuti, Abdul Hakim Siregar, Slamet Raharjo","doi":"10.1515/jbcpp-2022-0158","DOIUrl":"https://doi.org/10.1515/jbcpp-2022-0158","url":null,"abstract":"Objectives: Endurance exercise is an effective strategy for maintaining an anti-inflammatory environment and weight management. However, the effect of this type of exercise on decreasing body fat and TNF-α levels and increasing adiponectin levels is controversial. The aims of this study was to prove the effects of weight-bearing vs. non-weight-bearing endurance exercise on reducing body fat and inflammatory markers in obese females.Methods: 24 obese adolescents were recruited from female students from the State University of Malang. The interventions given in this study were weight-bearing endurance exercise (WBEE), and non-weight-bearing endurance exercise (NWBEE). Serum TNF-α levels and serum adiponectin levels were evaluated using enzyme-linked immunosorbent assay (ELISA). Statistical analysis techniques use paired sample T-test with a significant level of 5%.Results: Results of the statistical analysis show that the average body fat (PBF, FM, FFM) and TNF-α levels before endurance exercise vs. after endurance exercise in both types of exercise experienced a significant decrease (p≤0.05), while average adiponectin levels in both types of exercise experienced a significant increase before endurance exercise vs. after endurance exercise (p≤0.001).Conclusions: In general, it can be concluded that weight-bearing and non-weight-bearing endurance exercise with moderate-intensity for 40 min/exercise session reduce body fat and TNF-α levels and increase adiponectin levels as a marker of inflammation in obese female.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":"34 2","pages":"215-225"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9116302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diabetic wound healing approaches: an update. 糖尿病伤口愈合方法:最新进展。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2023-03-01 DOI: 10.1515/jbcpp-2021-0340

Raghuvir Keni, Farmiza Begum, Karthik Gourishetti, Gollapalle Lakshminarayanashastry Viswanatha, Pawan Ganesh Nayak, Krishnadas Nandakumar, Rekha R Shenoy

引用次数: 3

Cytokine release by human bone marrow stromal cells isolated from osteoarthritic and diabetic osteoarthritic patients in vitro. 骨关节炎和糖尿病骨关节炎患者骨髓基质细胞体外释放细胞因子的研究。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2023-03-01 DOI: 10.1515/jbcpp-2020-0320

Kar Wai Loh, Norshazliza Shaz, Simmrat Singh, Murali Malliga Raman, Hanumantha Rao Balaji Raghavendran, Tunku Kamarul

{"title":"Cytokine release by human bone marrow stromal cells isolated from osteoarthritic and diabetic osteoarthritic patients in vitro.","authors":"Kar Wai Loh, Norshazliza Shaz, Simmrat Singh, Murali Malliga Raman, Hanumantha Rao Balaji Raghavendran, Tunku Kamarul","doi":"10.1515/jbcpp-2020-0320","DOIUrl":"https://doi.org/10.1515/jbcpp-2020-0320","url":null,"abstract":"Objectives: Primary Osteoarthritis (OA) is a disease of progressive joints degeneration due to idiopathic causes. Recent evidence showed a positive relationship between OA and metabolic syndrome. This pilot study aimed to assess the baseline level of pro and anti-inflammatory cytokines in OA patients with or without Diabetic Mellitus (DM) and assess the effect of hydrogen peroxide (H2O2) in cytokine production.Methods: Patients with primary hip and knee OA were recruited, and 3 mL of bone marrow was harvested during joint replacement surgery. Bone marrow stromal cells (BMSC) was isolated and cultured in a culture flask for three passages. Later experiment was then sub-cultured in a well plate labeled as the control group and H2O2 (0.1 mM) treated group. ProcartaPlex® Multiplex Immunoassay was performed to measure cytokine levels produced by the BMSC at 0 h, as well as 72 h.Results: Cytokines such as tumor necrosis factor-alpha, interleukin (IL)-6, IL-8, and IL-1β generally exhibited higher cytokine levels in subjects with DM than in nonDM subjects at 0 and 72 h. For IL-17, its expression was similar in nonDM and DM groups at 0 and 72 h. Cytokine IL-10 showed no significant difference in both the groups while DM and nonDM groups treated with H2O2 showed decreased IL-4 levels compared to control groups at 72 h. Bone marrow cells from DM-OA are more vulnerable to chemical insult and are associated with higher levels of proinflammatory cytokines production and lower IL-4 level production.Conclusions: This study provides a clue that management of OA with co-morbidity like DM needs future studies.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":"34 2","pages":"177-185"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9113701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The effects of G protein-coupled receptor 30 (GPR30) on cardiac glucose metabolism in diabetic ovariectomized female rats. G蛋白偶联受体30 (GPR30)对糖尿病去卵巢雌性大鼠心脏糖代谢的影响

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2023-03-01 DOI: 10.1515/jbcpp-2021-0374

Mohammad Shahbazian, Faezeh Jafarynezhad, Maryam Yadeghari, Zeinab Farhadi, Sanaz Lotfi Samani, Mansour Esmailidehaj, Fatemeh Safari, Hossein Azizian

{"title":"The effects of G protein-coupled receptor 30 (GPR30) on cardiac glucose metabolism in diabetic ovariectomized female rats.","authors":"Mohammad Shahbazian, Faezeh Jafarynezhad, Maryam Yadeghari, Zeinab Farhadi, Sanaz Lotfi Samani, Mansour Esmailidehaj, Fatemeh Safari, Hossein Azizian","doi":"10.1515/jbcpp-2021-0374","DOIUrl":"https://doi.org/10.1515/jbcpp-2021-0374","url":null,"abstract":"Background: Diabetic cardiometabolic disorders are characterized by significant changes in cardiac metabolism and are increased in postmenopausal women, which emphasize the role of 17β-estradiol (E2). Despite this, there are few safe and effective pharmacological treatments for these disorders. The role of G protein-coupled estrogen receptor (GPR30), which mediates the non-genomic effects of E2, is mostly unexplored.Methods: In this study, we used ovariectomy (menopausal model) and type 2 diabetic (T2D) rats' models to evaluate the preclinical action of G-1 (GPR30 agonist) against cardiometabolic disorders. T2D was induced by a high-fat diet and a low dose of streptozotocin. G-1 was administrated for six weeks after the establishment of T2D.Results: We found that G-1 counteracts the effects of T2D and ovariectomy by increasing the body weight, reducing fasting blood sugar, heart weight, and heart weight to body weight ratio. Also, both ovariectomy and T2D led to decreases in the cardiac protein levels of hexokinase 2 (HK2) and GLUT4, while G-1-treated female rats reversed these changes and only increased HK2 protein level. In addition, T2D and ovariectomy increased glucose and glycogen content in the heart, but G-1 treatment significantly reduced them.Conclusions: In conclusion, our work demonstrates that G-1 as a selective GPR30 agonist is a viable therapeutic approach against T2D and cardiometabolic diseases in multiple preclinical female models.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":"34 2","pages":"205-213"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9172099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4