Journal of Basic and Clinical Physiology and Pharmacology最新文献_第2页

The impact of heavy metals exposure on male fertility: a scoping review of human studies. 重金属暴露对男性生育能力的影响：人类研究的范围审查。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-04-22 eCollection Date: 2025-03-01 DOI: 10.1515/jbcpp-2025-0049

Carlo Giulioni, Federico Falsetti, Valentina Maurizi, Francesco Del Giudice, Felice Crocetto, Ciro Imbimbo, Angelo Cafarelli

{"title":"The impact of heavy metals exposure on male fertility: a scoping review of human studies.","authors":"Carlo Giulioni, Federico Falsetti, Valentina Maurizi, Francesco Del Giudice, Felice Crocetto, Ciro Imbimbo, Angelo Cafarelli","doi":"10.1515/jbcpp-2025-0049","DOIUrl":"10.1515/jbcpp-2025-0049","url":null,"abstract":"Introduction: Male infertility is a critical global health issue, with environmental and occupational exposure to heavy metals, such as lead (Pb), cadmium (Cd), mercury (Hg), and arsenic (As), impacting male reproductive health. This scoping review aims to evaluate the effects of heavy metal exposure on semen parameters.Content: This study adhered to the 2020 PRISMA framework. A broad literature search was performed on January 2025, using Embase, PUBMED, and Scopus. A comprehensive literature search was performed using PubMed, Embase, and Scopus on January 12, 2025, using a combination of Medical Subject terms and keywords.Summary: Of the 1,709 identified studies, 21 met the inclusion criteria and were analyzed. Findings indicate that lead exposure negatively impacts sperm concentration, motility, and morphology, primarily through oxidative stress and enzymatic inhibition. Cadmium disrupts the blood-testis barrier and acrosomal function, leading to sperm abnormalities. Arsenic exposure is linked to oxidative stress, apoptosis, and impaired sperm motility.Outlook: The cumulative evidence supports a strong association between heavy metal exposure and male infertility. This review underscores the need for stricter occupational safety regulations and environmental policies to mitigate heavy metal exposure.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"129-137"},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes of systemic thrombolysis with reteplase in high-risk acute pulmonary embolism. 雷替普酶全身性溶栓治疗高危急性肺栓塞的疗效。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-04-16 eCollection Date: 2025-03-01 DOI: 10.1515/jbcpp-2024-0188

Leila Bigdelu, Mahla Deldar, Asal Yadollahi, Vafa Baradaran Rahimi

{"title":"Outcomes of systemic thrombolysis with reteplase in high-risk acute pulmonary embolism.","authors":"Leila Bigdelu, Mahla Deldar, Asal Yadollahi, Vafa Baradaran Rahimi","doi":"10.1515/jbcpp-2024-0188","DOIUrl":"10.1515/jbcpp-2024-0188","url":null,"abstract":"Objectives: High-risk pulmonary embolism (PE) is known as the presence of hemodynamic instability and has a high mortality rate, which necessitates immediate reperfusion treatment. According to current PE treatment guidelines, alteplase is the approved and preferred agent for systemic thrombolysis. Herein, we present the efficacy and safety of systemic thrombolysis with reteplase in patients with high-risk PE.Methods: The present retrospective observational study includes 30 patients with high-risk acute PE undergoing systemic thrombolysis with reteplase. All patients were in obstructive shock. The thrombolytic regimen consisted of two bolus doses of 10 U reteplase, given 30 min apart, followed by intravenous heparin.Results: All patients had elevated cardiac troponin levels. D-dimer levels were elevated in 28 (93.3 %) patients. Systolic blood pressure increased after thrombolysis with reteplase, and the dyspnea, tachypnea, and coughing improved in all patients. Mean SPO2 was 83.6 ± 6.96 % before treatment, which had risen to 95.7 ± 1.29 % after thrombolysis (p=0.059). Right ventricular dilatation was seen in all patients at presentation, which improved by 96.6 % after treatment and systolic pulmonary artery pressure decreased significantly in all patients at discharge. None of the patients needed to repeat thrombolytic therapy. There were no major hemorrhagic complications or death after thrombolysis, while 5 (16.7 %) patients experienced minor self-limiting bleeding.Conclusions: Reteplase, as two bolus injections of 10 U given 30 min apart, is an effective thrombolytic regimen in treating acute high-risk PE with a low risk of major hemorrhagic complications.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"215-220"},"PeriodicalIF":0.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxygen Toxicity as a Function of Time and Po₂. 氧毒性与时间和Po2的关系。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-04-10 Print Date: 1994-01-01 DOI: 10.1515/jbcpp-1994-050106

Ran Arieli

引用次数: 0

CONTENTS. 内容。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-04-10 Print Date: 1994-01-01 DOI: 10.1515/jbcpp-1994-toc0501

引用次数: 0

Magnesium Protects Against Anaphylactic Shock and Cardiac Myolysis in Guinea-Pigs. 镁对豚鼠过敏性休克和心肌溶解的保护作用。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-04-10 Print Date: 1994-01-01 DOI: 10.1515/jbcpp-1994-050104

Fabio Kusniec, Gabriella Fischer, Ben-Ami Sela, Yaakov Ashkenazy, Dan Fiegel, Sandra Moshonov, Uriel Zor

{"title":"Magnesium Protects Against Anaphylactic Shock and Cardiac Myolysis in Guinea-Pigs.","authors":"Fabio Kusniec, Gabriella Fischer, Ben-Ami Sela, Yaakov Ashkenazy, Dan Fiegel, Sandra Moshonov, Uriel Zor","doi":"10.1515/jbcpp-1994-050104","DOIUrl":"https://doi.org/10.1515/jbcpp-1994-050104","url":null,"abstract":"The pathophysiological responses to immune stress (IS) include activation of several processes which are dependent on cytosolic Ca2+ elevation. Magnesium frequently acts as a natural Ca2+ antagonist. In this study we have observed that Mg2 + can protect guinea-pigs against IS. Antigen-sensitized guinea-pigs, which had been fed a magnesiumdeficient diet, were given a single dose (15 mg) of MgCl2 intraperitoneally 1 h before antigen challenge. The development of anaphylactic shock (AS) was observed during the next 2 h, and the hearts were subsequently examined histologically for signs of cardiac myolysis (CM). Magnesium (i) reduced the incidence of CM from 40% to 10% (p<0.05); (ii) reduced the incidence of AS from 61% to 35% (p<0.05); (iii) attenuated the severity of the AS; and (iv) lowered mortality from 39% in the control to 19% in the Mg2+-treated group (p=0.1). Serum and tissue total [Mg2+] were not affected by the administration of MgCl2. Also, the serum and heart Mg2+ levels were the same whether or not the guinea-pigs developed AS or CM. In cell culture we demonstrated that by elevating the [Mg2+] in the medium bathing sensitized rat basophilic leukemia (RBL) cells, the increase in cytosolic [Ca2+] subsequent to antigen challenge was reduced from 174 ± 23.28% (1 mM) to 82.74 ± 13.22 % (3 mM). We conclude that a single treatment with Mg2+ can considerably diminish damage induced by immune stress, probably by its altering the Ca2+: Mg2+ratio. Since the physiological reaction to different types of stress is similar, Mg2 + could prove beneficial in preventing stress-induced shock in general. Studies examining the mechanisms by which Mg2 + exerts its effects thus provide a scientific basis for the current clinical use of Mg2 + in acute myocardial infarction (AMI) and asthma.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":"5 1","pages":"45-58"},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A New Class of Antiarrhythmic-Defibrillatory Compounds. 一类新的抗心律失常除颤剂化合物。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-04-10 Print Date: 1994-01-01 DOI: 10.1515/jbcpp-1994-050105

M Erez, D Varon

引用次数: 0

Dehydration and Rehydration in Donkeys: The Role of the Hind Gut as a Water Reservoir. 驴的脱水和补液：后肠作为贮水器的作用。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-04-10 Print Date: 1994-01-01 DOI: 10.1515/jbcpp-1994-050107

H Kasirer-Izraely, I Choshniak, A Shkolnik

{"title":"Dehydration and Rehydration in Donkeys: The Role of the Hind Gut as a Water Reservoir.","authors":"H Kasirer-Izraely, I Choshniak, A Shkolnik","doi":"10.1515/jbcpp-1994-050107","DOIUrl":"https://doi.org/10.1515/jbcpp-1994-050107","url":null,"abstract":"Body fluid distribution was measured in three donkeys, fully hydrated, following dehydration and after being rapidly rehydrated. In twenty other donkeys that were slaughtered to supply food for predators iri a safari zoo, the water content in the different compartments of the gastrointestinal tract (GIT) was assessed. Prior to being slaughtered, four of the animals were fully hydrated, four dehydrated and 12 dehydrated, rehydrated and then slaughtered and examined, four at 1, four at 3 and four at 5 hours following drinking. When the body mass of dehydrated donkeys dropped to 75.4± 2.4% of their initial value, total body water of the animals (HTO space), extracellular volume (SCN space) and plasma volume (EB space) were reduced to 76.6 ± 5.3%, 80.9 ± 10.6% and 73.2 ± 8.3% of their initial values, respectively. The amount of water retained in the GIT of the fully hydrated donkeys amounted to 15.9 ± 3.4 1, 19% of total body water. In the dehydrated donkeys it was only 7.4± 1.3 1. The calculated total intracellular volume in the dehydrated donkeys was only 14% lower than in the fully hydrated animals. When drinking was allowed, dehydrated donkeys consumed 17.6 ± 2.4 1 of water. The increase in the water content in the gut of newly rehydrated donkeys matched this volume, 80% of which was retained in the hind gut. During the five hours after drinking, only slow and moderate changes in the volume of the hind gut were recorded. Changes in plasma volume were also suppressed. It is suggested that the hind gut of the donkey, similar to the rumen of goats and sheep, plays a role as a water reservoir that helps maintain the osmotic stability of the body.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":"5 1","pages":"89-100"},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ion-Selective Channels in K562 Cells: A Patch-Clamp Analysis. K562细胞中的离子选择通道：一个膜片钳分析。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-04-10 Print Date: 1994-01-01 DOI: 10.1515/jbcpp-1994-050103

Jürgen Rettinger, Wolfgang Schwarz

{"title":"Ion-Selective Channels in K562 Cells: A Patch-Clamp Analysis.","authors":"Jürgen Rettinger, Wolfgang Schwarz","doi":"10.1515/jbcpp-1994-050103","DOIUrl":"https://doi.org/10.1515/jbcpp-1994-050103","url":null,"abstract":"Four types of ion-selective channels were found by the patch-clamp technique in the human erythroleucemia K562 cells. I)In cell-attached configuration at potentials less negative than -40 mV an 8 pS channel was detected. The potential dependence of channel activity suggests that this is the TTX-sensitive Na+ channel. II)A cation-selective channel was observed with equal permeability for Na+ and K+ and a potential-independent single-channel conductance of 19 pS. The channel is activated by intracellular Ca2+ and inhibited by TEA. ΙΠ)A predominantly anion-selective channel was identified with the selectivity sequence N03\" >J\" > G\" = Br » S04 2·. The single-channel conductance shows outward rectification, and is in symmetrical NaCl solution 19 pS at -60 mV and 54 pS at +50 mV. The open- and closedtime distributions suggest one open and at least four closed states. At submicromolar concentrations, the open state is blocked by H2DIDS leading to channel flicker between open and blocked channel; higher concentrations (apparent Kj=6.8 μΜ) lead to a longer-lasting blocked state. Both components of inhibition are reversible. IV)In addition, an 8 pS, Na+- and K+- selective channel could be induced by application of palytoxin. For channel activity, the presence of extracellular Na+ is essential. It is assumed that the Na+, K+-pump molecule is involved in the channel formation. Similarly, it is discussed whether the anionselective channel represents a pore conformation of an electrically silent anion exchanger.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":"5 1","pages":"27-44"},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anions, Membrane Resistance and Ventricular Fibrillation. 阴离子、膜阻力与心室颤动。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-04-10 Print Date: 1994-01-01 DOI: 10.1515/jbcpp-1994-050102

Michael J Curtis, Paul D Ridley

引用次数: 0

Chemical Defibrillation in Acute Myocardial Ischaemia: a Hypothesis. 急性心肌缺血的化学除颤：一个假说。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-04-10 Print Date: 1994-01-01 DOI: 10.1515/jbcpp-1994-050101

Michael J Curtis

引用次数: 0