Journal of Basic and Clinical Physiology and Pharmacology最新文献_第2页

Exploring the therapeutic potential of GLP-1 receptor agonists in the management of obstructive sleep apnea: a comprehensive review. 探索GLP-1受体激动剂在阻塞性睡眠呼吸暂停治疗中的治疗潜力：一项全面的综述。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-01-14 eCollection Date: 2025-01-01 DOI: 10.1515/jbcpp-2024-0193

Amruth Akhil Alluri, Merin Mohan Kurien, Nikhil Patel Pokar, Alekhya Madarapu, Sreeja Sadam, Nikhitha Puvvala, Rajmohan Seetharaman

{"title":"Exploring the therapeutic potential of GLP-1 receptor agonists in the management of obstructive sleep apnea: a comprehensive review.","authors":"Amruth Akhil Alluri, Merin Mohan Kurien, Nikhil Patel Pokar, Alekhya Madarapu, Sreeja Sadam, Nikhitha Puvvala, Rajmohan Seetharaman","doi":"10.1515/jbcpp-2024-0193","DOIUrl":"10.1515/jbcpp-2024-0193","url":null,"abstract":"Obstructive Sleep Apnea (OSA) is a prevalent sleep disorder marked by repeated episodes of partial or complete upper airway obstruction during sleep, which leads to intermittent hypoxia and fragmented sleep. These disruptions negatively impact cardiovascular health, metabolic function, and overall quality of life. Obesity is a major modifiable risk factor for OSA, as it contributes to both anatomical and physiological mechanisms that increase the likelihood of airway collapse during sleep. While continuous positive airway pressure (CPAP) therapy remains the gold standard for OSA treatment, its limitations - particularly issues with patient adherence - underscore the need for alternative or adjunct therapeutic options. One such option is the use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs), which are widely recognized for their ability to reduce body weight and improve metabolic health. Emerging evidence suggests that GLP-1 RAs may offer therapeutic benefits in managing OSA, particularly by addressing obesity, a key contributor to the condition. This narrative review seeks to explore the role of GLP-1 RAs in the treatment of OSA, evaluating their efficacy in reducing OSA severity and discussing their broader clinical implications for future research and practice.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"13-25"},"PeriodicalIF":0.0,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and safety of resmetirom in MASLD and MASH: network meta-analysis of randomized clinical trials. 雷司替罗在MASLD和MASH中的疗效和安全性：随机临床试验的网络荟萃分析。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-01-09 eCollection Date: 2025-01-01 DOI: 10.1515/jbcpp-2024-0140

Hazem Ayesh, Azizullah Beran, Sajida Suhail, Suhail Ayesh, Kevin Niswender

{"title":"Efficacy and safety of resmetirom in MASLD and MASH: network meta-analysis of randomized clinical trials.","authors":"Hazem Ayesh, Azizullah Beran, Sajida Suhail, Suhail Ayesh, Kevin Niswender","doi":"10.1515/jbcpp-2024-0140","DOIUrl":"10.1515/jbcpp-2024-0140","url":null,"abstract":"Introduction: Metabolic-Associated Steatohepatitis-Related Liver Disease (MASLD) and, its progressive form, Metabolic-Associated Steatohepatitis (MASH) pose significant global health challenges. Current therapeutic strategies targeting metabolic abnormalities have shown promise but lack specificity for the liver. Thyroid hormones, particularly thyroid hormone receptor beta (THR-β) agonists like resmetirom, offer a targeted approach to liver-related pathways.Content: A network meta-analysis (NMA) comparing different doses of resmetirom to placebo for MASLD and MASH was conducted. PubMed, Scopus, Cochrane, and Web of Science were searched for relevant randomized controlled trials (RCTs). Efficacy outcomes included histological, radiological, and biochemical parameters, while safety outcomes comprised adverse events and treatment discontinuation.Summary: Resmetirom demonstrated dose-dependent efficacy in histological and radiological assessments, with the 100 mg dose showing superior MASH resolution and hepatic fat reduction. Biochemical markers indicated improved liver function with resmetirom treatment. However, adverse events, particularly diarrhea and nausea, were more prevalent in the resmetirom group, leading to higher treatment discontinuation rates.Outlook: Resmetirom shows promise as a therapeutic option for MASLD and MASH management, with significant improvements in liver health parameters. However, safety concerns warrant careful monitoring in clinical practice. Further research is needed to optimize its long-term safety and efficacy.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"3-11"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142948885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factor assessment for post-thrombolytic coronary angiogram normalcy in young myocardial infarction patients.

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2024-12-31 eCollection Date: 2025-01-01 DOI: 10.1515/jbcpp-2024-0064

Venkatramani Mahadevan, Abirami Karuppiah, Shravan Venkatraman

{"title":"Risk factor assessment for post-thrombolytic coronary angiogram normalcy in young myocardial infarction patients.","authors":"Venkatramani Mahadevan, Abirami Karuppiah, Shravan Venkatraman","doi":"10.1515/jbcpp-2024-0064","DOIUrl":"https://doi.org/10.1515/jbcpp-2024-0064","url":null,"abstract":"Objectives: Acute myocardial infarction is a critical medical condition that poses a significant risk to life. It is distinguished by the abrupt cessation of blood flow to a specific segment of the cardiac muscle. Acute myocardial infarction accounts for more than 15 % of global mortality annually.Methods and results: A total of 433 young patients admitted with acute coronary syndrome - myocardial infarction underwent thrombolysis with fibrin specific agents followed by underwent diagnostic coronary angiogram between 01.09.2021 and 31.10.2022. The odds ratio showed a value of 1.973, which is much higher than the individuals with diabetes (0.306). Young individuals (25.9 %) with hypertension have a greater chance of recovery by thrombolysis.Conclusions: The factors that contribute for the myocardial infarction should be recognized and addressed. Recognizing and addressing these risk factors through education, lifestyle modifications, and early intervention are crucial for preventing myocardial infarction and promoting good health.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":"36 1","pages":"51-59"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality by design: how poor adherence to guidelines holds back urological app innovation. 设计质量：对指导方针的不遵守如何阻碍了泌尿外科应用程序的创新。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2024-12-13 eCollection Date: 2025-01-01 DOI: 10.1515/jbcpp-2024-0205

Emanuele Capasso, Mariagrazia Marisei, Ferdinando Fusco, Enrico Sicignano, Felice Crocetto

引用次数: 0

A cross-sectional study on the effects of physical activity on hand grip strength in type 2 diabetes mellitus patients. 关于体育锻炼对 2 型糖尿病患者手部握力影响的横断面研究。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2024-11-28 eCollection Date: 2025-01-01 DOI: 10.1515/jbcpp-2024-0176

Praveena Meyyazhagan, Thamaraiselvi Kanagaraj, Nachal Annamalai

{"title":"A cross-sectional study on the effects of physical activity on hand grip strength in type 2 diabetes mellitus patients.","authors":"Praveena Meyyazhagan, Thamaraiselvi Kanagaraj, Nachal Annamalai","doi":"10.1515/jbcpp-2024-0176","DOIUrl":"10.1515/jbcpp-2024-0176","url":null,"abstract":"Objectives: The pervasiveness of type 2 diabetes mellitus (T2DM) is rapidly increasing worldwide, with physical inactivity being one of the major risk factors. Hand grip strength (HGS) is an important indicator of overall physical functioning and has been associated with various health-related outcomes. The purpose of this study was to investigate the impact of physical activity on the HGS of patients with type 2 diabetes mellitus (T2DM). Furthermore, it scrutinizes the relationship between physical activity and HGS in terms of sex.Methods: A cross-sectional study including a total of 140 patients with T2DM was performed. Physical activity levels were assessed via the International Physical Activity Questionnaire (IPAQ). HGS was measured via a Camry digital handgrip dynamometer. Statistical analysis was performed via SPSS software, and statistical approaches such as ANOVA, Pearson correlation and t tests were used.Results: The results of this research will contribute to the detection of the influence of physical activity and its association with HGS. These findings reveal that physical activity has a significant effect on HGS and that there is a positive correlation between physical activity and increased hand grip strength in individuals with T2DM.Conclusions: The outcomes offer valuable insights into physical activity and muscle strength, which can aid in the early detection of physical disability. The findings of this study will be valuable for healthcare providers and professionals to suggest relevant physical activities for diabetic patients.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"27-37"},"PeriodicalIF":0.0,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to: 6-OHDA mediated neurotoxicity in SH-SY5Y cellular model of Parkinson disease suppressed by pretreatment with hesperidin through activating L-type calcium channels. 更正：在帕金森病 SH-SY5Y 细胞模型中使用橙皮甙预处理可通过激活 L 型钙通道抑制 6-OHDA 介导的神经毒性。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2024-11-18 eCollection Date: 2024-11-01 DOI: 10.1515/jbcpp-2024-0122

Leila Elyasi, Mehrdad Jahanshahi, S B Jameie, Hatef Ghasemi Hamid Abadi, Emsehgol Nikmahzar, Masoumeh Khalili, Melika Jameie, Mana Jameie

引用次数: 0

Effect of omega-3 fatty acids supplementation on muscle mass, fat mass, and visceral fat of hemodialysis patients; A randomized clinical trial. 补充欧米伽-3 脂肪酸对血液透析患者肌肉质量、脂肪质量和内脏脂肪的影响；随机临床试验。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2024-11-14 Print Date: 2024-11-26 DOI: 10.1515/jbcpp-2024-0148

Saheb Abbas Torki, Zahra Roumi, Atefeh Tahavorgar, Zahra Salimi, Saeideh Mohammadi, Soheila Shekari, Zahra Saeedirad, Arezoo Amjadi, Pouya Mirzaee, Hanieh Shafaei, Bojlul Bahar, Fatemeh Mofidi, Masoud Khosravi, Saeid Doaei, Maryam Gholamalizadeh

{"title":"Effect of omega-3 fatty acids supplementation on muscle mass, fat mass, and visceral fat of hemodialysis patients; A randomized clinical trial.","authors":"Saheb Abbas Torki, Zahra Roumi, Atefeh Tahavorgar, Zahra Salimi, Saeideh Mohammadi, Soheila Shekari, Zahra Saeedirad, Arezoo Amjadi, Pouya Mirzaee, Hanieh Shafaei, Bojlul Bahar, Fatemeh Mofidi, Masoud Khosravi, Saeid Doaei, Maryam Gholamalizadeh","doi":"10.1515/jbcpp-2024-0148","DOIUrl":"10.1515/jbcpp-2024-0148","url":null,"abstract":"Objectives: Several studies demonstrated the benefits of omega-3 fatty acids supplementation in chronic kidney disease (CKD) patients. The objective of this study was to investigate the effect of omega-3 fatty acids supplementation in body composition, specifically on the lean body mass and fat mass in hemodialysis patients.Methods: In this randomized, double-blind, placebo-controlled clinical trial, a total of 120 end-stage renal disease (ESRD) patients were randomly allocated into two groups. The intervention group has taken three grams of omega-3 fatty acids daily while the placebo group received three grams of medium chain triglycerides (MCT) as a placebo for a total of 2 months. The changes in the body mass index (BMI) and body composition (fat mass, muscle, and visceral fat) were assessed at baseline and following the intervention.Results: No significant difference was found in the mean of BMI, FAT, muscle, and visceral fat in the intervention group compared to the control group after the intervention. After two months of omega-3 fatty acid supplementation, the study found no statistically significant impact of omega-3 fatty acids supplementation on various indices of body composition. The effect of ω-3 supplementation in reducing visceral fat was close to significant (p=0.08).Conclusions: This study suggests that there is currently inadequate evidence to support the effect of omega-3 fatty acid supplementation in improving anthropometric measurements in patients with CKD, except a partial effect on visceral fat. Further large-scale and long-term clinical trials are needed to confirm the present results.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"347-352"},"PeriodicalIF":0.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immediate effect of sunlight exposure through blue glass on blood pressure in hypertensive patients: a randomized controlled trial. 通过蓝色玻璃照射阳光对高血压患者血压的直接影响：随机对照试验。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2024-11-13 eCollection Date: 2024-11-01 DOI: 10.1515/jbcpp-2024-0081

Deepa Yoganathan, Maheshkumar Kuppusamy, Edmin Christa, Saran Murugan, Vijayabharathi Elangovan, Preetha Jayakumar, Sangamithraa Rammohan

{"title":"Immediate effect of sunlight exposure through blue glass on blood pressure in hypertensive patients: a randomized controlled trial.","authors":"Deepa Yoganathan, Maheshkumar Kuppusamy, Edmin Christa, Saran Murugan, Vijayabharathi Elangovan, Preetha Jayakumar, Sangamithraa Rammohan","doi":"10.1515/jbcpp-2024-0081","DOIUrl":"10.1515/jbcpp-2024-0081","url":null,"abstract":"Objective: Hypertension affects approximately 1.28 billion adults worldwide, driving the search for integrative therapeutic approaches alongside conventional treatments. While chromotherapy, particularly blue light exposure, has historical roots in traditional medicine and its specific impact on blood pressure regulation remains understudied. So, the present study aims to investigate the immediate impact of exposure to blue glass through sunlight on blood pressure in hypertensive individuals.Methods: This randomized controlled trial was carried out with a sample of 60 hypertensive patients, who were divided into two groups: a study group that received blue glass exposure for 20 min and a control group that received exposure to colourless glass. The primary outcome measures were systolic and diastolic blood pressure, pulse rate, and oxygen saturation levels.Results: The results of the study revealed statistically significant differences in systolic blood pressure (p=0.006) and pulse rate (p=0.005) after the intervention in the study group and no such changes were noted in the control group.Conclusions: The findings of this study suggest that blue glass exposure has a significant impact on reducing blood pressure and pulse rate in hypertensive patients, indicating its potential use as a integrative treatment in the management of hypertension.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"371-374"},"PeriodicalIF":0.0,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Choroidal and retinal alteration after long-term use of tadalafil: a prospective non-randomized clinical trial. 长期服用他达拉非后脉络膜和视网膜的改变：一项前瞻性非随机临床试验。

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2024-11-13 eCollection Date: 2024-11-01 DOI: 10.1515/jbcpp-2024-0118

Luca D'Andrea, Gianluigi Califano, Marco Abate, Marco Capece, Claudia Collà Ruvolo, Felice Crocetto, Maria Laura Passaro, Gilda Cennamo, Ciro Costagliola

{"title":"Choroidal and retinal alteration after long-term use of tadalafil: a prospective non-randomized clinical trial.","authors":"Luca D'Andrea, Gianluigi Califano, Marco Abate, Marco Capece, Claudia Collà Ruvolo, Felice Crocetto, Maria Laura Passaro, Gilda Cennamo, Ciro Costagliola","doi":"10.1515/jbcpp-2024-0118","DOIUrl":"10.1515/jbcpp-2024-0118","url":null,"abstract":"Objectives: The purpose of this study is to investigate choroidal and retinal vascular features in patients taking PDE5is by measuring dynamic vascular alterations and neurostructural features of the retina before and after oral tadalafil administration.Methods: The current clinical research involved 22 patients treated with tadalafil 20 mg on alternate days (OAD) after nerve-sparing robotic radical prostatectomy (NS-RARP) for prostate cancer. Patients underwent SD-OCT to assess ganglion cell complex (GCC), retinal nerve fiber layer (RNFL), and subfoveal choroidal thickness (SFCT), as well as OCTA to assess superficial capillary plexus (SCP), deep capillary plexus (DCP), choriocapillaris (CC), foveal avascular zone (FAZ), and radial peripapillary capillary thickness (RPC). All patients were evaluated at baseline (t0), and 3 (t1) and 6 (t2) months after the use of oral tadalafil.Results: A statistically significant reduction in DCP and CC vessel density was found at t2 compared to baseline. According to the SFCT parameter, a statistically significant increase was observed from t0 to t1, and from t1 to t2. GCC parameter increased at t2 compared to baseline in a statistically significant way. No statistically significant differences were recorded between t0, t1 and t2 for the SCP, RPC, FAZ area, RNFL parameter.Conclusions: Retinal and optic disc toxicity may be detected using modifications of capillary vessel density. Further studies are needed to detect the possible progression or regression of ocular or systemic vascular complications in long-term follow-up.","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":" ","pages":"361-369"},"PeriodicalIF":0.0,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The alarming link between the COVID-19 pandemic and stroke: why ignoring this association after relapse of the disease has dangerous consequences. COVID-19 大流行与中风之间令人震惊的联系：为什么疾病复发后忽视这种联系会带来危险后果？

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2024-10-28 eCollection Date: 2024-11-01 DOI: 10.1515/jbcpp-2024-0179

Nader Aghakhani, Roya Naderi

引用次数: 0