{"title":"Oxygen Toxicity as a Function of Time and Po<sub>2</sub>.","authors":"Ran Arieli","doi":"10.1515/jbcpp-1994-050106","DOIUrl":null,"url":null,"abstract":"<p><p>The quantification of 0 2 toxicity as a function of exposure time (t) and Po2 has been based mainly on the empirical rectangular hyperbola. The non-linear response of the 02-damaged physiological variable (DMG) as a function of time at constant Po2 can be related to the dependence of dDMG/dt on the DMG. The kinetics of the 02 - derived chemical species suggests a power relationship between the DMG and Po2 rather than a linear relationship. The combination of time and Po2 considerations suggests two models: 1) DMG = a(ebt - l)Po2 c and 2) DMG = a-tbPo2 c, where a, b and c are constant. Non-linear regression of the different parameters of 0 2 toxicity showed a preference for model 2, with b=2. Possible mechanisms underlying the kinetics of 0 2 toxicity and the use of the equation for its prediction are discussed.</p>","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":"5 1","pages":"67-88"},"PeriodicalIF":0.0000,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Basic and Clinical Physiology and Pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1515/jbcpp-1994-050106","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"1994/1/1 0:00:00","PubModel":"Print","JCR":"Q3","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 0
Abstract
The quantification of 0 2 toxicity as a function of exposure time (t) and Po2 has been based mainly on the empirical rectangular hyperbola. The non-linear response of the 02-damaged physiological variable (DMG) as a function of time at constant Po2 can be related to the dependence of dDMG/dt on the DMG. The kinetics of the 02 - derived chemical species suggests a power relationship between the DMG and Po2 rather than a linear relationship. The combination of time and Po2 considerations suggests two models: 1) DMG = a(ebt - l)Po2 c and 2) DMG = a-tbPo2 c, where a, b and c are constant. Non-linear regression of the different parameters of 0 2 toxicity showed a preference for model 2, with b=2. Possible mechanisms underlying the kinetics of 0 2 toxicity and the use of the equation for its prediction are discussed.
期刊介绍：
The Journal of Basic and Clinical Physiology and Pharmacology (JBCPP) is a peer-reviewed bi-monthly published journal in experimental medicine. JBCPP publishes novel research in the physiological and pharmacological sciences, including brain research; cardiovascular-pulmonary interactions; exercise; thermal control; haematology; immune response; inflammation; metabolism; oxidative stress; and phytotherapy. As the borders between physiology, pharmacology and biochemistry become increasingly blurred, we also welcome papers using cutting-edge techniques in cellular and/or molecular biology to link descriptive or behavioral studies with cellular and molecular mechanisms underlying the integrative processes. Topics: Behavior and Neuroprotection, Reproduction, Genotoxicity and Cytotoxicity, Vascular Conditions, Cardiovascular Function, Cardiovascular-Pulmonary Interactions, Oxidative Stress, Metabolism, Immune Response, Hematological Profile, Inflammation, Infection, Phytotherapy.
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