精浆瘦素升高可能与精索静脉曲张存在和BMI相关。

Q3 Pharmacology, Toxicology and Pharmaceutics

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-03-28 DOI:10.1515/jbcpp-2025-0010

Humam D Mohammed, Rana R Al-Saadi, Estabraq A R Al-Wasiti

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引用次数: 0

摘要

目的：男性不育影响20-30 %的不育夫妇，精索静脉曲张是一个常见的原因。瘦素（一种参与能量平衡和生殖的激素）与男性生育参数之间的关系仍不完全清楚，特别是在精索静脉曲张和肥胖的背景下。因此，本研究旨在评估精血浆瘦素与不育患者的其他临床和人口统计学数据之间的关系。方法：在这项横断面研究中，从2023年11月到2024年3月，对90名男性（29名患有精索静脉曲张，61名没有）进行了评估。采用ELISA法测定精血瘦素水平。研究对象根据身体质量指数（BMI）被分为三种体重类别：正常体重、超重和肥胖。通过精液分析、生殖激素评估和相关分析来检验瘦素水平与各种临床参数之间的关系。结果：精索静脉曲张患者的精血瘦素水平明显高于无精索静脉曲张患者（9.27 vs. 7.65 ng/mL）。结论：精索静脉曲张患者的精血瘦素水平较高，且与中东人群的BMI密切相关。这些结果共同表明，精液中的瘦素水平可以作为精索静脉曲张相关男性生育问题的生物学指标。

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Elevated seminal plasma leptin may correlate with varicocele presence and BMI.

Objectives: Male infertility affects 20-30 % of infertile couples worldwide, and varicocele being a common cause. The relationship between leptin, a hormone involved in energy homeostasis and reproduction, and male fertility parameters remains incompletely understood, particularly in the context of varicocele and obesity. Thus, the current study sought to assess the associations between seminal plasma leptin and other clinical and demographic data of infertile patients.

Methods: In this cross-sectional study, 90 men (29 with varicocele, 61 without) were evaluated from November 2023 to March 2024. Seminal plasma leptin levels were measured using ELISA. Study subjects were classified into three weight classifications using body mass index (BMI) measurements: normal weight, overweight, and obese. Semen analysis, reproductive hormones assessment, and correlation analyses were performed to examine relationships between leptin levels and various clinical parameters.

Results: Patients with varicocele demonstrated significantly higher seminal plasma leptin levels compared to those without (9.27 vs. 7.65 ng/mL, p<0.05), this association persisted following statistical adjustment for demographic and clinical variables. In addition, BMI was the strongest independent predictor of seminal plasma leptin levels (β=0.26, p<0.01). Interestingly, overweight individuals showed higher leptin levels than both normal weight and obese participants. A significant inverse relationship found between leptin concentrations and luteinizing hormone levels (ρ=-0.375, p<0.05), while a positive association was found with progressive motility of sperm (ρ=0.225, p<0.05).

Conclusions: Higher levels of leptin were found in seminal specimens of varicocele-diagnosed subjects and strongly correlate with BMI in this Middle Eastern population. These results together propose that leptin's level in semen could be useful as a biological indicator for varicocele-associated male fertility issues.

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来源期刊

Journal of Basic and Clinical Physiology and Pharmacology Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

3.90

自引率

0.00%

发文量

期刊介绍： The Journal of Basic and Clinical Physiology and Pharmacology (JBCPP) is a peer-reviewed bi-monthly published journal in experimental medicine. JBCPP publishes novel research in the physiological and pharmacological sciences, including brain research; cardiovascular-pulmonary interactions; exercise; thermal control; haematology; immune response; inflammation; metabolism; oxidative stress; and phytotherapy. As the borders between physiology, pharmacology and biochemistry become increasingly blurred, we also welcome papers using cutting-edge techniques in cellular and/or molecular biology to link descriptive or behavioral studies with cellular and molecular mechanisms underlying the integrative processes. Topics: Behavior and Neuroprotection, Reproduction, Genotoxicity and Cytotoxicity, Vascular Conditions, Cardiovascular Function, Cardiovascular-Pulmonary Interactions, Oxidative Stress, Metabolism, Immune Response, Hematological Profile, Inflammation, Infection, Phytotherapy.