Anions, Membrane Resistance and Ventricular Fibrillation.

Q3 Pharmacology, Toxicology and Pharmaceutics

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2025-04-10 Print Date: 1994-01-01 DOI:10.1515/jbcpp-1994-050102

Michael J Curtis, Paul D Ridley

引用次数: 0

Abstract

Clinical success in prevention of sudden cardiac death has been poor. New approaches to prevention of ventricular fibrillation (VF), one of the main causes of sudden cardiac death, are clearly needed. In the present article we have reviewed some of our own data which support the notion that VF may be prevented by manipulation of chloride homeostasis /1,2/. Our studies have revealed a novel approach to VF suppression via alteration of sarcolemmal membrane resistance.

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阴离子、膜阻力与心室颤动。

预防心源性猝死的临床成功率一直很低。心室颤动（VF）是心源性猝死的主要原因之一，显然需要新的预防方法。在本文中，我们回顾了一些我们自己的数据，这些数据支持通过控制氯化物稳态来预防VF的观点。我们的研究揭示了一种通过改变肌上皮膜抗性来抑制VF的新方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Basic and Clinical Physiology and Pharmacology Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

3.90

自引率

0.00%

发文量

期刊介绍： The Journal of Basic and Clinical Physiology and Pharmacology (JBCPP) is a peer-reviewed bi-monthly published journal in experimental medicine. JBCPP publishes novel research in the physiological and pharmacological sciences, including brain research; cardiovascular-pulmonary interactions; exercise; thermal control; haematology; immune response; inflammation; metabolism; oxidative stress; and phytotherapy. As the borders between physiology, pharmacology and biochemistry become increasingly blurred, we also welcome papers using cutting-edge techniques in cellular and/or molecular biology to link descriptive or behavioral studies with cellular and molecular mechanisms underlying the integrative processes. Topics: Behavior and Neuroprotection, Reproduction, Genotoxicity and Cytotoxicity, Vascular Conditions, Cardiovascular Function, Cardiovascular-Pulmonary Interactions, Oxidative Stress, Metabolism, Immune Response, Hematological Profile, Inflammation, Infection, Phytotherapy.