Journal of Cerebral Blood Flow and Metabolism最新文献_第4页

Type-1-to-type-2 transition of brain microvascular pericytes induced by cytokines and disease-associated proteins: Role in neuroinflammation and blood-brain barrier disruption. 细胞因子和疾病相关蛋白诱导的脑微血管周细胞 1 型向 2 型转变：在神经炎症和血脑屏障破坏中的作用

IF 5.4 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-10-30 DOI: 10.1177/0271678X241296270

Diana G Bohannon, Laurie L Wellman, Marcus Kaul, Elena V Galkina, Ming-Lei Guo, Prasun K Datta, Woong-Ki Kim

{"title":"Type-1-to-type-2 transition of brain microvascular pericytes induced by cytokines and disease-associated proteins: Role in neuroinflammation and blood-brain barrier disruption.","authors":"Diana G Bohannon, Laurie L Wellman, Marcus Kaul, Elena V Galkina, Ming-Lei Guo, Prasun K Datta, Woong-Ki Kim","doi":"10.1177/0271678X241296270","DOIUrl":"10.1177/0271678X241296270","url":null,"abstract":"While the concept of pericyte heterogeneity in the brain microvasculature is becoming more widely accepted, little is known about how they arise, or their functional contributions to the blood-brain barrier (BBB). We therefore set out to examine the distribution of subtypes of pericytes at the BBB and sought to elucidate some of their functional characteristics by examining their unique mRNA expression patterns. We demonstrate that type-1 pericytes (PC1) that are associated with young healthy brains and BBB homeostasis, can transition into type-2 pericytes (PC2) that are associated with disease and BBB breakdown, both in vitro and in vivo, in the presence of both endogenous and disease associated ligands. We identified PC1 and PC2 in single-cell RNA-sequencing from vascular enriched mouse brain and identified transcriptional differences between PC1 and PC2. PC2 showed increased expression of genes associated with phagocytosis and peripheral immune cell infiltration. On the contrary, PC1 displayed increased expression of genes involved in hedgehog signaling, which is known to promote tight junction formation at the BBB. Our data support the PC1-to-PC2 transition as an origin of PC diversity and suggest a functional role for PC1 in maintaining BBB homeostasis and PC2 in responding to pathological conditions.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"271678X241296270"},"PeriodicalIF":5.4,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anesthetics in pathological cerebrovascular conditions. 病理脑血管情况下的麻醉剂。

IF 5.4 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-10-25 DOI: 10.1177/0271678X241295857

Yuhui Hou, Wei Ye, Ziyuan Tang, Fengxian Li

{"title":"Anesthetics in pathological cerebrovascular conditions.","authors":"Yuhui Hou, Wei Ye, Ziyuan Tang, Fengxian Li","doi":"10.1177/0271678X241295857","DOIUrl":"10.1177/0271678X241295857","url":null,"abstract":"The increasing prevalence of pathological cerebrovascular conditions, including stroke, hypertensive encephalopathy, and chronic disorders, underscores the importance of anesthetic considerations for affected patients. Preserving cerebral oxygenation and blood flow during anesthesia is paramount to prevent neurological deterioration. Furthermore, protecting vulnerable neurons from damage is crucial for optimal outcomes. Recent research suggests that anesthetic agents may provide a potentially therapeutic approach for managing pathological cerebrovascular conditions. Anesthetics target neural mechanisms underlying cerebrovascular dysfunction, thereby modulating neuroinflammation, protecting neurons against ischemic injury, and improving cerebral hemodynamics. However, optimal strategies regarding mechanisms, dosage, and indications remain uncertain. This review aims to clarify the physiological effects, mechanisms of action, and reported neuroprotective benefits of anesthetics in patients with various pathological cerebrovascular conditions. Investigating anesthetic effects in cerebrovascular disease holds promise for developing novel therapeutic strategies.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"271678X241295857"},"PeriodicalIF":5.4,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuronal plasma biomarkers in acute ischemic stroke. 急性缺血性中风的神经元血浆生物标志物。

IF 5.4 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-10-25 DOI: 10.1177/0271678X241293537

Julia K Gundersen, Fernando Gonzalez-Ortiz, Thomas Karikari, Bjørn-Eivind Kirsebom, Katrin Mertes, Henrik Zetterberg, Hlin Kvartsberg, Ole Morten Rønning, Berglind Gísladóttir, Kaj Blennow, Tormod Fladby

{"title":"Neuronal plasma biomarkers in acute ischemic stroke.","authors":"Julia K Gundersen, Fernando Gonzalez-Ortiz, Thomas Karikari, Bjørn-Eivind Kirsebom, Katrin Mertes, Henrik Zetterberg, Hlin Kvartsberg, Ole Morten Rønning, Berglind Gísladóttir, Kaj Blennow, Tormod Fladby","doi":"10.1177/0271678X241293537","DOIUrl":"10.1177/0271678X241293537","url":null,"abstract":"Early imaging-based detection of acute ischemic stroke (AIS) has improved in the era of reperfusion therapy. Despite of this, prognosis of outcome after AIS remains a challenge. Therefore, parameters that support clinical decision making are sought. Blood-based biomarkers have the potential to provide valuable information in addition to the established prognostic factors. Neuronal biomarkers of acute or degenerative neuronal injury have shown to be reliably detected in plasma. These biomarkers are well-established in neurodegenerative pathology, such as Alzheimer's disease. In this study, we explored the association between stroke diameter and plasma biomarkers for neuronal injury and tau pathophysiology (brain-derived tau [BD-tau], phosphorylated-tau-217 [p-tau21] and neurofilament light [NfL]) in patients (n = 193) admitted to the acute ward, Akershus University Hospital. All patients received a final diagnosis of AIS, transient ischemic attack or stroke mimics. Blood samples were obtained the day after admission. We find that levels of BD-tau (p = .004) and NfL (p = .011) were higher after AIS than in patients with stroke mimics. The cortical stroke diameter correlated with BD-tau (tau-b = 0.64, p < .001) and p-tau217 (tau-b = 0.36, p = .003). Linear regression confirmed BD-tau to be the strongest variable associated with stroke diameter, pointing to the potential clinical value of plasma BD-tau in outcome prediction after AIS.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"271678X241293537"},"PeriodicalIF":5.4,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intra-cisterna-magna bevacizumab injection (ICM-BI) reproduces pathological alterations of cerebral small vessel diseases. 蝶窦内注射贝伐珠单抗（ICM-BI）可重现脑小血管疾病的病理改变。

IF 5.4 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-10-25 DOI: 10.1177/0271678X241295856

Xinmei Kang, Xiaotao Su, Tiemei Li, Shisi Wang, Huipeng Huang, Yuxin Liu, Chunyi Li, Xiaohui Deng, Mengyan Hu, Tingting Lu, Lei Wei, Wei Cai, Zhengqi Lu

{"title":"Intra-cisterna-magna bevacizumab injection (ICM-BI) reproduces pathological alterations of cerebral small vessel diseases.","authors":"Xinmei Kang, Xiaotao Su, Tiemei Li, Shisi Wang, Huipeng Huang, Yuxin Liu, Chunyi Li, Xiaohui Deng, Mengyan Hu, Tingting Lu, Lei Wei, Wei Cai, Zhengqi Lu","doi":"10.1177/0271678X241295856","DOIUrl":"10.1177/0271678X241295856","url":null,"abstract":"General modeling strategies for sporadic cerebral small blood vessel diseases (CSVDs) include limiting blood stream in large blood vessels and inducing systemic hypertension, in which small blood vessel deficit is either a secondary or concomitant pathology. In the current study, we introduce that intra-cisterna-magna Bevacizumab injection (ICM-BI) directly causes cerebral small blood vessel injury by neutralizing VEGF-A, the indispensable growth factor for angiogenesis. ICM-BI reproduces neuro-functional impairment, tight junction loss, cerebral micro-bleeds (CMBs), amyloid peptide accumulation, neuronal injury, white matter loss, and glial cell activation, which are common manifestations of sporadic CSVDs. Compared with existing CSVD models, small blood vessel injury is more prominent in the ICM-BI brain. Moreover, no significant alteration in large blood vessels or peripheral organs after ICM-BI is recorded. We thus propose that ICM-BI is a neat, economic and applicable methodology to establish murine sporadic CSVD model.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"271678X241295856"},"PeriodicalIF":5.4,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aging affects the mouse brain in a region-specific manner. 衰老以特定区域的方式影响小鼠大脑。

IF 5.4 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-10-18 DOI: 10.1177/0271678X241289780

Ling Cai, Yueman Zhang, Yuxi Zhou, Xin Wang

引用次数: 0

Statistical non-independence of brain metabolite concentrations whether normalized to creatine or water. 无论是以肌酸还是以水为标准，大脑代谢物浓度在统计上都不具有独立性。

IF 5.4 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-10-18 DOI: 10.1177/0271678X241290018

Richard J Maddock

引用次数: 0

More severe cerebral small vessel disease associated with poor leptomeningeal collaterals in symptomatic intracranial atherosclerotic stenosis. 有症状的颅内动脉粥样硬化性狭窄患者脑小血管病变较严重，且脑外膜侧支较差。

IF 5.4 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-10-18 DOI: 10.1177/0271678X241292537

Yuying Liu, Shuang Li, Xuan Tian, Jill Abrigo, Bonnie Yk Lam, Jize Wei, Lina Zheng, Yu Liu, Ziqi Li, Tingjun Liang, Bonaventure Ym Ip, Thomas W Leung, Xinyi Leng

{"title":"More severe cerebral small vessel disease associated with poor leptomeningeal collaterals in symptomatic intracranial atherosclerotic stenosis.","authors":"Yuying Liu, Shuang Li, Xuan Tian, Jill Abrigo, Bonnie Yk Lam, Jize Wei, Lina Zheng, Yu Liu, Ziqi Li, Tingjun Liang, Bonaventure Ym Ip, Thomas W Leung, Xinyi Leng","doi":"10.1177/0271678X241292537","DOIUrl":"10.1177/0271678X241292537","url":null,"abstract":"We investigated the association between cerebral small vessel disease (CSVD) and ipsilateral leptomeningeal collateral (LMC) status in patients with symptomatic intracranial atherosclerotic stenosis (sICAS). In 108 patients with 50-99% symptomatic intracranial internal carotid artery or M1 middle cerebral artery stenosis, 4 CSVD imaging markers (lacunes, cerebral microbleeds, enlarged perivascular spaces [EPVSs], and white matter hyperintensities [WMHs]) were assessed in MRI. Score of 0 or 1 was assigned to each marker and added up as a summary CSVD score (ranging 0-4) to reflect an overall CSVD burden. Ipsilateral LMC status was assessed by determining the laterality of distal vessels in anterior and posterior cerebral artery territories on CT angiography. Moderate-to-severe EPVSs (adjusted odds ratio [aOR] = 4.15; p = 0.031) and WMHs (aOR = 5.90; p = 0.010), and higher summary CSVD score (aOR = 1.66; p = 0.030) were independently associated with poor LMCs. There was significant interaction between stenosis percentage in sICAS and summary CSVD score on poor LMCs (p = 0.022 for interaction), when higher CSVD score was significantly associated with poor LMCs in patients with severe sICAS (aOR = 2.84; p = 0.011) but not in those with moderate sICAS. The findings indicated possibly adverse effect of CSVD on the recruitment or development of LMCs in sICAS patients, especially in patients with severe sICAS.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"271678X241292537"},"PeriodicalIF":5.4,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Somatosensory migraine auras evoked by bihemispheric cortical spreading depression events in human parietal cortex. 人类顶叶皮层双半球皮质扩张性抑郁事件诱发的躯体感觉性偏头痛光环。

IF 5.4 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-10-13 DOI: 10.1177/0271678X241290606

Cedric Gollion, Rune H Christensen, Håkan Ashina, Haidar M Al-Khazali, Patrick M Fisher, Faisal Mohammad Amin, Martin Lauritzen, Messoud Ashina

{"title":"Somatosensory migraine auras evoked by bihemispheric cortical spreading depression events in human parietal cortex.","authors":"Cedric Gollion, Rune H Christensen, Håkan Ashina, Haidar M Al-Khazali, Patrick M Fisher, Faisal Mohammad Amin, Martin Lauritzen, Messoud Ashina","doi":"10.1177/0271678X241290606","DOIUrl":"10.1177/0271678X241290606","url":null,"abstract":"Cortical spreading depression (CSD) is associated with pronounced alterations in cerebral blood flow. These alterations can be captured using high-field functional magnetic resonance imaging (fMRI). While compelling clinical and experimental data suggest that CSD is involved in the pathogenesis of migraine aura, the mechanistic intricacies remain poorly understood. Here, we use visual stimulus-induced blood oxygen level-dependent (BOLD) fMRI responses to characterize spatiotemporal alterations in cerebral blood flow during spontaneous attacks with migraine aura. Six adult participants diagnosed with migraine with aura underwent BOLD fMRI scans with a visual stimulation paradigm, consisting of flickering checkerboard stimulation. Our results revealed that auras with somatosensory symptoms corresponded with bilateral alterations of stimulus-induced BOLD responses in the somatosensory cortex, exhibiting anterior-to-posterior propagation and absence of antecedent occipital abnormalities. These altered stimulus-induced BOLD responses were bilateral, despite a unilateral manifestation of aura symptoms, and had no relationship with positive or negative aura symptoms. The bilateral abnormalities in stimulus-induced BOLD responses completes our current knowledge on migraine aura.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"271678X241290606"},"PeriodicalIF":5.4,"publicationDate":"2024-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intravenous administration of muse cells improves cerebral ischemia outcome via immunomodulation in the spleen. 静脉注射缪斯细胞可通过脾脏的免疫调节改善脑缺血的预后。

IF 5.4 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-10-13 DOI: 10.1177/0271678X241290363

Yuya Kato, Daiki Aburakawa, Ryosuke Tashiro, Yuan Zhou, Sherif Rashad, Hidenori Endo, Teiji Tominaga, Kuniyasu Niizuma

{"title":"Intravenous administration of muse cells improves cerebral ischemia outcome via immunomodulation in the spleen.","authors":"Yuya Kato, Daiki Aburakawa, Ryosuke Tashiro, Yuan Zhou, Sherif Rashad, Hidenori Endo, Teiji Tominaga, Kuniyasu Niizuma","doi":"10.1177/0271678X241290363","DOIUrl":"10.1177/0271678X241290363","url":null,"abstract":"Ischemic stroke is a leading cause of disability and death globally. Stem cell therapies are emerging as a frontier for enhancing post-stroke recovery, with Muse cells-a subclass of pluripotent stem cells-demonstrating considerable promise. Muse cells are notable not only for their potential in cell replacement but also for their role in modulating immune responses following cerebral infarction. In the present study, we administered Muse cells intravenously to mice after inducing a stroke via distal middle cerebral artery occlusion. We evaluated motor outcomes, splenocyte populations, cytokine profiles, and gene expression 2 weeks after inducing stroke. Additionally, comparisons were drawn between outcomes in splenectomized mice and those receiving adoptive splenocyte transfer to discern the specific influence of the spleen on treatment efficacy. Our findings revealed that Muse cell therapy facilitates motor recovery, an effect that is compromised in the absence of the spleen. Spleens in treated mice exhibited a shift in neutrophil counts, increased cytokine activity, and a notable uptick in the expression of genes related to protein folding. These insights affirm the potential therapeutic effect of Muse cells in post-stroke treatment strategies, with their efficacy attributed, at least in part, to immunomodulatory pathways involving the spleen.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"271678X241290363"},"PeriodicalIF":5.4,"publicationDate":"2024-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A support vector machine-based approach to guide the selection of a pseudo-reference region for brain PET quantification. 基于支持向量机的方法，用于指导脑 PET 定量伪参考区域的选择。

IF 5.4 2区医学

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-10-13 DOI: 10.1177/0271678X241290912

Chunmeng Tang, Greet Vanderlinden, Gwen Schroyen, Sabine Deprez, Koen Van Laere, Michel Koole

{"title":"A support vector machine-based approach to guide the selection of a pseudo-reference region for brain PET quantification.","authors":"Chunmeng Tang, Greet Vanderlinden, Gwen Schroyen, Sabine Deprez, Koen Van Laere, Michel Koole","doi":"10.1177/0271678X241290912","DOIUrl":"10.1177/0271678X241290912","url":null,"abstract":"A Support Vector Machine (SVM) based approach was developed to identify a pseudo-reference region for brain PET scans with the aim of reducing interscan and intersubject variability. By training a binary linear SVM classifier with PET datasets from two different groups, potential pseudo-reference regions were identified by considering their regional average or total contribution to the classification score. This approach was evaluated in three cohorts with different brain PET tracers: (1) 11C-PiB PET scans of Alzheimer's disease (AD) patients and age-matched controls (OC); (2) baseline and blocking scans of an 11C-UCB-J PET occupancy study; and (3) 18F-DPA-714 PET scans for healthy controls (HC) and chemo-treated women with breast cancer (BC). In the first cohort, cerebellum, brainstem, and subcortical white matter were confirmed as pseudo-reference regions. The same regions were identified for the second cohort using either the VT maps or the SUV images. In the third cohort, cerebellum and brainstem were identified as pseudo-reference regions, alongside subcortical white matter and temporal cortex. In addition, the SVM-based approach demonstrated robust performance even with a reduced number of subjects, therefore confirming its applicability in identifying pseudo-reference regions without a priori assumptions and with only limited data across different PET tracers.","PeriodicalId":15325,"journal":{"name":"Journal of Cerebral Blood Flow and Metabolism","volume":" ","pages":"271678X241290912"},"PeriodicalIF":5.4,"publicationDate":"2024-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0