Journal of Chemical Research-s最新文献_第5页

The design and synthesis of benzylpiperazine-based edaravone derivatives and their neuroprotective activities 苯甲哌嗪基依达拉奉衍生物的设计合成及其神经保护活性

Journal of Chemical Research-s Pub Date : 2022-11-01 DOI: 10.1177/17475198221116827

Mengjie Gao, Shuangyan Ma, Tong Xu, Nan Jiang, Yi Xu, Y. Zhong, Bin Wu

{"title":"The design and synthesis of benzylpiperazine-based edaravone derivatives and their neuroprotective activities","authors":"Mengjie Gao, Shuangyan Ma, Tong Xu, Nan Jiang, Yi Xu, Y. Zhong, Bin Wu","doi":"10.1177/17475198221116827","DOIUrl":"https://doi.org/10.1177/17475198221116827","url":null,"abstract":"New edaravone derivatives containing a benzylpiperazine moiety are designed and synthesized. The structures are characterized by 1H NMR, 13C NMR, and high-resolution mass spectrometry. The potential neuroprotective activities of the target compounds are evaluated in differentiated rat pheochromocytoma cells (PC12 cells) and in mice subjected to acute cerebral ischemia. Most of the target compounds showed neuroprotective activities both in vivo and in vitro, especially 1-(4-(4-fluorobenzyl) piperazin-1-yl)-2-(4-(5-hydroxy-3-methyl-1H-pyrazol-1-yl)phenoxy)ethanone and 1-(4-(4-nitrobenzyl)piperazin-1-yl)-2-(4-(5-hydroxy-3-methyl-1H-pyrazol-1-yl)phenoxy)ethanone, which displayed significant protective effects on cell viability against damage caused by H2O2, and remarkably prolonged the survival time of mice subjected to acute cerebral ischemia and decreased the mortality rate at all doses. These compounds represent lead compounds for the further discovery of neuroprotective agents for treating cerebral ischemic stroke. Molecular docking studies and basic structure–activity relationships are also presented.","PeriodicalId":15318,"journal":{"name":"Journal of Chemical Research-s","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74375018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermal and thermo-oxidative stability of a series of palladium and platinum ferrocenylamine sulfides and selenides 一系列钯和铂二茂铁胺硫化物和硒化物的热稳定性和热氧化稳定性

Journal of Chemical Research-s Pub Date : 2022-11-01 DOI: 10.1177/17475198221141979

H. Ali, Isra H. Ali

{"title":"Thermal and thermo-oxidative stability of a series of palladium and platinum ferrocenylamine sulfides and selenides","authors":"H. Ali, Isra H. Ali","doi":"10.1177/17475198221141979","DOIUrl":"https://doi.org/10.1177/17475198221141979","url":null,"abstract":"Ferrocenylamine complexes have found increasing applications in the fields of catalysis in various organic reactions, industry, medical treatments and enzyme–activity determinations. Therefore, information related to the thermal and thermo-oxidative stability of these compounds is important for such applications; however, this information is currently limited. Twenty previously prepared palladium and platinum ferrocenylamine complexes with systematic structural variations are examined for their thermal (under nitrogen) and thermo-oxidation stability (under atmospheric air) using thermogravimetry (TG), differential thermal analysis (DTG), and differential scanning calorimetry (DSC) techniques. Degradation products are identified by comparing thermogravimetric analysis and theoretical calculations. Structure–stability studies are also discussed. The results show that all the compounds have high thermal and thermo-oxidative stabilities of up to 265 and 173 °C, respectively. Electron–donating substituents enhance the thermal and thermo-oxidative stabilities of the palladium complexes (t-Bu, selenide electrophiles and dielectrophiles), while those with destabilizing effects are aromatic substituents (Ph and tolyl). Most platinum ferrocenylamine sulfides and selenides show higher thermal and thermo-oxidative stabilities than their corresponding palladium analogs. All the prepared compounds show high thermal and thermo-oxidative stability which reinforces their catalytic and industrial applications. However, their thermal stability is higher than their thermo-oxidative stability.","PeriodicalId":15318,"journal":{"name":"Journal of Chemical Research-s","volume":"387 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74973649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of CO2-doped spiro-OMeTAD hole transport layer on FA(1−x)Cs x PbI3 perovskite solar cells co2掺杂spiro-OMeTAD空穴传输层对FA(1−x)Cs x PbI3钙钛矿太阳能电池的影响

Journal of Chemical Research-s Pub Date : 2022-11-01 DOI: 10.1177/17475198221136079

Z. Fan, Chuwu Xing, Y. Tan, Jinxia Xu, Lingyun Liu, Yuanming Zhou, Yan Jiang

{"title":"The effect of CO2-doped spiro-OMeTAD hole transport layer on FA(1−x)Cs x PbI3 perovskite solar cells","authors":"Z. Fan, Chuwu Xing, Y. Tan, Jinxia Xu, Lingyun Liu, Yuanming Zhou, Yan Jiang","doi":"10.1177/17475198221136079","DOIUrl":"https://doi.org/10.1177/17475198221136079","url":null,"abstract":"Black-phase formamidinium lead iodine with 1.48 eV bandgap is considered to be the most promising material for improving the near-theoretical limit efficiency of perovskite solar cells, but at room temperature, black-phase formamidinium lead iodine easily transforms into the yellow non-perovskite phase formamidinium lead iodine. Here, different ratios of Cs+-incorporated formamidinium lead iodine prepared by one-step processing with the stability and power conversion efficiency of formamidinium lead iodine perovskite solar cells are investigated. FA0.85Cs0.15PbI3 shows the highest power conversion efficiency of 10.63% (Voc = 1.04 V, Jsc = 16.81 mA cm−2, and fill factor = 0.60), and the unencapsulated device maintained 60% of the initial power conversion efficiency after storage in air with 40% humidity for 186 h with an active area of 0.1 cm2, when the ratios of Cs+ reached 15% (x = 0.15) in formamidinium lead iodine. However, the efficiency of perovskite solar cell–based formamidinium lead iodine is still low. In this work, a simple but an effective strategy was carried out to rapidly and fully oxidize hole transport layer solution by doping CO2 or O2 under ultraviolet light irradiation to increase the conductivity of hole transport layer, thereby improving the power conversion efficiency of solar cells. The results show that FA0.85Cs0.15PbI3 solar cells by CO2-doped hole transport layer for 90 s exhibited the highest power conversion efficiency of 16.11% (VOC = 1.11 V, JSC = 19.73 mA cm−2, and fill factor = 0.74). The improved photovoltaic performance is attributed to CO2-doped spiro-OMeTAD increasing charge carrier density and accelerating charge separation, thereby inducing higher conductivity. CO2 or O2 doped can rapidly and fully oxidize spiro-OMeTAD, and reduce the solar cell fabrication time; it is beneficial to the commercial use of perovskite solar cells.","PeriodicalId":15318,"journal":{"name":"Journal of Chemical Research-s","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86984924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of 3-(2-oxopropyl)-2-arylisoindolinone derivatives via a three-component reaction of diaryliodonium salts with 2-formylbenzonitriles and phenylacetylenes 二芳基碘盐与2-甲酰苯并腈和苯乙炔三组分反应合成3-(2-氧丙基)-2-芳基异吲哚酮衍生物

Journal of Chemical Research-s Pub Date : 2022-11-01 DOI: 10.1177/17475198211063799

Yang Li, Yuan Li, Haiyang Fei, Rui Kong, Zhen-Wen Yu, Liu He

引用次数: 0

Palladium-catalyzed transfer hydrogenation of terminal alkynes using ethanol as the hydrogen donor 钯催化乙醇为氢供体的末端炔转移加氢反应

Journal of Chemical Research-s Pub Date : 2022-11-01 DOI: 10.1177/17475198221145838

Jie Hui, Feng Wang

引用次数: 0

Reducible amino acid based cationic lipids with a naphthalimide moiety as non-viral gene vehicles 具有萘酰亚胺部分的可还原氨基酸基阳离子脂质作为非病毒基因载体

Journal of Chemical Research-s Pub Date : 2022-11-01 DOI: 10.1177/17475198221145850

Jian Wang, Deyu Wang, Tingdong Du, Wen-Jing Yi, Qiang Liu

引用次数: 1

Synthesis of stable flowerlike MgAl-LDH@MIL-88A and its adsorption performance for fluoride 稳定花状MgAl-LDH@MIL-88A的合成及其对氟的吸附性能

Journal of Chemical Research-s Pub Date : 2022-11-01 DOI: 10.1177/17475198221106680

Wenqing Ma, Yuantao Chen, Jianxian Qin, G. Hu, Cheng-Qun Xu

{"title":"Synthesis of stable flowerlike MgAl-LDH@MIL-88A and its adsorption performance for fluoride","authors":"Wenqing Ma, Yuantao Chen, Jianxian Qin, G. Hu, Cheng-Qun Xu","doi":"10.1177/17475198221106680","DOIUrl":"https://doi.org/10.1177/17475198221106680","url":null,"abstract":"MgAl-LDH@MIL-88A as an effective adsorbent was successfully prepared by a simple stirring method in water bath through loading MIL-88A onto the surface of flowerlike MgAl-LDH, which was synthesized via solvothermal method. Interestingly, the results of characterizations showed that the MIL-88A could still grow, but extrude the brucite-like layers of MgAl-LDH. The influences of initial solution pH, contact time, temperature, and co-existing ions on the adsorption performance of MgAl-LDH@MIL-88A were studied systematically by batch static adsorption experiments. It was found that MgAl-LDH@MIL-88A represented the highest adsorption loading of fluoride (14.00 mg g−1) at initial pH 7.0 in 420 min. The uptake process was described appropriately by the pseudo-second-order, the Temkin and the Freundlich isotherm models. The thermodynamic parameters confirmed the endothermic and spontaneous nature of adsorption. MgAl-LDH@MIL-88A was the green adsorbent as the residual mental contents ([Mg2+] = 1.095 mg L−1, [Fe3+] = 0.007 mg L−1, [Al3+] = 0.076 mg L−1) after adsorption met the Chinese sanitary standard for drinking water (GB 5749-2006). The mechanism of fluoride removal by MgAl-LDH@MIL-88A involved the electrostatic interactions between Fe3+ of MIL-88A and fluoride, and ligand exchange among hydroxyl groups of MgAl-LDH, carboxylate groups of the C4H4O4 and fluoride.","PeriodicalId":15318,"journal":{"name":"Journal of Chemical Research-s","volume":"35 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72467476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utilization of 4-fluoro-7-nitro-2,1,3-benzoxadiazole (NBD-F) as a fluorogenic reagent for the development of a spectrofluorometric assay method for taurine in energy drinks 利用4-氟-7-硝基-2,1,3-苯并恶二唑(NBD-F)作为荧光试剂，建立了能量饮料中牛磺酸的荧光光谱测定方法

Journal of Chemical Research-s Pub Date : 2022-09-01 DOI: 10.1177/17475198221114760

Ahmed O. Alnajjar, Abdalla Ahmed Elbashir, R. Elgorashe, Ammar M. Ebrahim, A. M. Idris, H. A. Abd El‐Lateef

{"title":"Utilization of 4-fluoro-7-nitro-2,1,3-benzoxadiazole (NBD-F) as a fluorogenic reagent for the development of a spectrofluorometric assay method for taurine in energy drinks","authors":"Ahmed O. Alnajjar, Abdalla Ahmed Elbashir, R. Elgorashe, Ammar M. Ebrahim, A. M. Idris, H. A. Abd El‐Lateef","doi":"10.1177/17475198221114760","DOIUrl":"https://doi.org/10.1177/17475198221114760","url":null,"abstract":"The development of a simple, inexpensive, sensitive, and selective spectrofluorometric assay method for taurine in energy drinks utilizing 4-fluoro-7-nitro-2,1,3-benzoxadiazole as a fluorogenic agent is described. Conditions affecting the derivatization reaction are investigated and optimized. The optimal conditions are found to be as follows: buffer, pH 10; 4-fluoro-7-nitro-2,1,3-benzoxadiazoleconcentration, 0.05%; reaction time, 30 min; temperature, 50 °C. Fluorescence measurements are carried out at a wavelength of 542 nm, with excitation at a wavelength of 485 nm. The method is validated under the optimum conditions. The method is found to be linear in the range of 2.0–12.5 µg/mL, with a correlation coefficient of 0.9993. The limits of detection and quantification (µg/mL) are 0.6 and 2.02, respectively, which are appropriate for taurine assays in commercial energy drinks. In addition, the proposed method recorded excellent accuracy since the recovery values caused by presence of excipients are found to be in the range of 99.3%–102.87%. The values of relative standard deviation for intra- and inter-day precision were found to be in the ranges of 0.236%–0.659% and 2.12%–2.63%, respectively.","PeriodicalId":15318,"journal":{"name":"Journal of Chemical Research-s","volume":"240 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72801987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A glassy carbon electrode modified with polyaniline nanowires: An electrochemically effective surface area and an electrocatalytic activity for the oxidation of methanol under alkaline conditions 聚苯胺纳米线修饰的玻碳电极:在碱性条件下甲醇氧化的电化学有效表面积和电催化活性

Journal of Chemical Research-s Pub Date : 2022-09-01 DOI: 10.1177/17475198221123414

L. T. Tran, H. V. Tran, H. Cao, Anh Van Nguyen, C. D. Huynh

{"title":"A glassy carbon electrode modified with polyaniline nanowires: An electrochemically effective surface area and an electrocatalytic activity for the oxidation of methanol under alkaline conditions","authors":"L. T. Tran, H. V. Tran, H. Cao, Anh Van Nguyen, C. D. Huynh","doi":"10.1177/17475198221123414","DOIUrl":"https://doi.org/10.1177/17475198221123414","url":null,"abstract":"Polyaniline nanowires are directly synthesized on a glassy carbon electrode (3 mm diameter) by an electrochemical process. The polyaniline nanowires, of uniform size, a diameter of 85–95 nm, and high conductivity, distribute evenly throughout the surface of the working electrode. Electrochemical measurements are conducted in order to determine the electrochemically effective surface area of the obtained glassy carbon electrode modified with polyaniline nanowires, and an investigation of the electrocatalytic activity of polyaniline nanowires for the oxidation of methanol under alkaline conditions is carried out. The electrochemically effective surface area of the glassy carbon electrode modified with polyaniline nanowires is nearly 27 times larger than that of a glassy carbon electrode. In a cyclic voltammetry curve of the glassy carbon electrode modified with polyaniline nanowires measured in a 3.0 M CH3OH and 0.5 M KOH solution, an anodic peak corresponding to the oxidation of methanol under alkaline conditions appears at 0.17 V with a peak current of 34.4 μA.","PeriodicalId":15318,"journal":{"name":"Journal of Chemical Research-s","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86809475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Homolytic aromatic substitution of acyl radicals: Oxidative coupling of 2-methylquinolines with quinoxalines 酰基自由基的均解芳取代:2-甲基喹啉与喹啉的氧化偶联

Journal of Chemical Research-s Pub Date : 2022-09-01 DOI: 10.1177/17475198221126026

Xue Li, X. Wu, Jia Feng Yu, Yuanqing Zhang, Zhong Ke Hou, Yuanyuan Xie

引用次数: 0