Journal of Chemical Research-s最新文献_第4页

A label- and enzyme-free fluorescence assay based on thioflavin T–induced G-quadruplexes for the detection of telomerase activity 基于巯基黄素t诱导的g -四联体的无标记和无酶荧光检测端粒酶活性

Journal of Chemical Research-s Pub Date : 2023-01-01 DOI: 10.1177/17475198221139085

Zhe Chen, Yunxia Wang

{"title":"A label- and enzyme-free fluorescence assay based on thioflavin T–induced G-quadruplexes for the detection of telomerase activity","authors":"Zhe Chen, Yunxia Wang","doi":"10.1177/17475198221139085","DOIUrl":"https://doi.org/10.1177/17475198221139085","url":null,"abstract":"A label- and enzyme-free fluorescence assay based on thioflavin T–induced G-quadruplexes is developed to sensitively and specifically detect telomerase activity. Thioflavin T has a dual role as an efficient inducer and fluorescent probe, and the incorporation of thioflavin T into the thioflavin T–induced G-quadruplexes results in an intense fluorescence enhancement. In the presence of thioflavin T and K+, G-quadruplexes are formed by elongation of the telomerase substrate primer that is catalyzed by telomerase extracted from cancer cells. Thus, the telomerase activity in cancer cell extracts can be evaluated by measuring the thioflavin T fluorescence. More importantly, thioflavin T can specifically recognize and bind to G-quadruplexes, whereas it cannot recognize single- and double-stranded DNAs, which leads to the thioflavin T–based fluorescence assay exhibiting a reduced background and improved signal-to-noise ratio. As a result, the proposed assay has the linear range from 5 to 200 HeLa cells and the detection limit is 34 HeLa cells, which holds great potential for use in the detection of telomerase activity and the diagnosis of cancer.","PeriodicalId":15318,"journal":{"name":"Journal of Chemical Research-s","volume":"150 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84308878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and enzymatic inhibition effects of thiazolidinedione 3C-like protease inhibitors 噻唑烷二酮类3c样蛋白酶抑制剂的合成及酶促抑制作用

Journal of Chemical Research-s Pub Date : 2023-01-01 DOI: 10.1177/17475198231152556

Xin Ye, Yuhua Li, Lina Guo, Yiling Yao, Rouyu Zhu, Shuang Wei, Hua Diao, Zhiyu Shao

引用次数: 0

Preparation of magnetic Co–Fe layered double hydroxides and its adsorption properties for the removal of methyl orange 磁性钴铁层状双氢氧化物的制备及其对甲基橙的吸附性能

Journal of Chemical Research-s Pub Date : 2023-01-01 DOI: 10.1177/17475198221150382

Yuye Xie, Fa-Ping Ye, Su-qin Zhao

{"title":"Preparation of magnetic Co–Fe layered double hydroxides and its adsorption properties for the removal of methyl orange","authors":"Yuye Xie, Fa-Ping Ye, Su-qin Zhao","doi":"10.1177/17475198221150382","DOIUrl":"https://doi.org/10.1177/17475198221150382","url":null,"abstract":"In this study, Co–Fe layered double hydroxides are prepared by a hydrothermal method. The Co–Fe layered double hydroxides are used as an adsorbent for the investigation of the thermodynamic parameters and adsorption kinetics of methyl orange from aqueous solution. The results show that adsorption is affected by adsorbent dosage, adsorption time, and temperature. The characteristics of samples are investigated using X-ray powder diffraction, scanning electron microscopy, Fourier-transform infrared spectroscopy, and N2 adsorption–desorption isotherms. The adsorption saturation level of Co–Fe layered double hydroxides on methyl orange is studied, with the results showing that the maximum uptake capacity for methyl orange is 10.21 mg g−1 based on Co–Fe layered double hydroxides. The adsorption kinetics of methyl orange is consistent with the Temkin isotherm equation and quasi-secondary kinetic model. Furthermore, separation is easily accomplished under the action of an applied magnetic field. The prepared Co–Fe layered double hydroxides can be applied as an effective adsorbent for decontamination of anionic dyes in industrial effluents.","PeriodicalId":15318,"journal":{"name":"Journal of Chemical Research-s","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84040275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A study on the viscosity, density, and derivative properties of 1-alkyl-3-methylimidazolium bis((trifluoromethyl)sulfonyl)imides with benzo-15-crown-5 binary mixtures 1-烷基-3-甲基咪唑-双((三氟甲基)磺酰)亚胺与苯并-15-冠-5二元混合物的粘度、密度和衍生物性质研究

Journal of Chemical Research-s Pub Date : 2023-01-01 DOI: 10.1177/17475198231156358

Ju Tian, Qi Tang, Yongshen Zhang, Yuzhen Shu, L. Zhang, Weiming Zheng

{"title":"A study on the viscosity, density, and derivative properties of 1-alkyl-3-methylimidazolium bis((trifluoromethyl)sulfonyl)imides with benzo-15-crown-5 binary mixtures","authors":"Ju Tian, Qi Tang, Yongshen Zhang, Yuzhen Shu, L. Zhang, Weiming Zheng","doi":"10.1177/17475198231156358","DOIUrl":"https://doi.org/10.1177/17475198231156358","url":null,"abstract":"The essential factors that affect the interfacial mass transfer rate of crown ether–ionic liquid systems are studied by examining the physicochemical properties of mixtures of ionic liquids with benzo-15-crown-5. In the present work, the 1-alkyl-3-methylimidazolium bis((trifluoromethyl)sulfonyl)imides ionic liquids ([C2MIm][NTf2], [C3MIm][NTf2], [C4MIm][NTf2], and [C5MIm][NTf2]) are adopted as the solvent and benzo-15-crown-5 is used as the solute. A series of binary mixtures of the ionic liquid and benzo-15-crown-5, with different molar fractions of ionic liquids, is formulated by the weight method. The viscosity and density are determined for four binary mixtures of ionic liquid and benzo-15-crown-5 at atmospheric pressure in a temperature range of 298.15 to 343.15 K. The values obtained for viscosity and density are fitted with empirical equations, and the energy barrier, a-constant, and the isobaric thermal expansion coefficient are all calculated. Interactions between the ionic liquid and the solute benzo-15-crown-5 are analyzed, and the above properties are discussed by comparison with systems in which different solutes are present in the same ionic liquid. It is found that interactions between the ionic liquid and benzo-15-crown-5 in the mixtures are more intense than in mixed systems composed of ionic liquids and other solutes.","PeriodicalId":15318,"journal":{"name":"Journal of Chemical Research-s","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80825920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fischer indole synthesis in DMSO/AcOH/H2O under continuous flow conditions 连续流动条件下DMSO/AcOH/H2O合成Fischer吲哚

Journal of Chemical Research-s Pub Date : 2023-01-01 DOI: 10.1177/17475198221150384

Mei Wang, Shenghu Yan, Yue Zhang, Shunlin Gu

引用次数: 0

The solvation of SOH group in hydrated HSO4−(H2O) n clusters 水合HSO4−(H2O) n团簇中SOH基团的溶剂化

Journal of Chemical Research-s Pub Date : 2023-01-01 DOI: 10.1177/17475198231153994

Huiyan Li

引用次数: 0

Hydrothermal synthesis of polyaniline nanospheres coupled with graphene oxide for enhanced specific capacitance performances 水热合成与氧化石墨烯耦合的聚苯胺纳米球以增强比电容性能

Journal of Chemical Research-s Pub Date : 2022-11-01 DOI: 10.1177/17475198221136045

Shanxin Xiong, Yang Xu, Xiaoqin Wang, Ming Gong, Jia Chu, Runlan Zhang, Bohua Wu, Chenxu Wang, Zhen Li

{"title":"Hydrothermal synthesis of polyaniline nanospheres coupled with graphene oxide for enhanced specific capacitance performances","authors":"Shanxin Xiong, Yang Xu, Xiaoqin Wang, Ming Gong, Jia Chu, Runlan Zhang, Bohua Wu, Chenxu Wang, Zhen Li","doi":"10.1177/17475198221136045","DOIUrl":"https://doi.org/10.1177/17475198221136045","url":null,"abstract":"Polyaniline is one of the most common electrode materials for supercapacitors. The morphology of polyaniline directly affects the properties of polyaniline. In this paper, a new method for preparing hollow polyaniline nanospheres is described. Polyaniline-S with solid and hollow structures are successfully synthesized by the hydrothermal method, through varying the amounts of the catalyst and oxidant. The prepared hollow nanospheres have uniform particle size, a smooth surface, and uniform wall thickness. The hollow structure provides rapid permeability to the material, facilitating the transfer and transport of charges and ions in the electrolyte, and it can also act as an ion storage tank to increase the accumulation of ions inside. The specific capacitance of polyaniline-S is high at 235 F g-1 at 0.5 A g-1. To reduce the aggregation of polyaniline-S and improve the electrochemical activity, polyaniline-S, and graphene oxide are composited using the interfacial electrostatic interaction. The content of graphene oxide has a significant influence on the electrochemical performance of the composites. The specific capacitance of the polyaniline-S/ graphene oxide composite with a 10% loading amount of graphene oxide reaches 535 F g-1 at 0.5 A g-1, increase of nearly 128% compared to representing a significant polyaniline-S. The specific capacitance retention rate is 93.6% after 10,000 cycles.","PeriodicalId":15318,"journal":{"name":"Journal of Chemical Research-s","volume":"105 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79251272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A polymerizable difunctional photoinitiator featuring a bio-based group and its photoinitiating properties 一种具有生物基基团的可聚合双官能光引发剂及其光引发性能

Journal of Chemical Research-s Pub Date : 2022-11-01 DOI: 10.1177/17475198221136063

Yanfang Zhou, R. Zhong, Zhengjie Wang

{"title":"A polymerizable difunctional photoinitiator featuring a bio-based group and its photoinitiating properties","authors":"Yanfang Zhou, R. Zhong, Zhengjie Wang","doi":"10.1177/17475198221136063","DOIUrl":"https://doi.org/10.1177/17475198221136063","url":null,"abstract":"A polymerizable difunctional photoinitiator 2-methylene-succinic acid bis-{2-[4-(2-hydroxy-2-methylpropionyl)phenoxy]ethyl} ester (IAHHMP) based on the commercial photoinitiator 2-hydroxy-1-[4-(2-hydroxyethoxy)phenyl]-2-methylpropanone (HHMP) and a biorenewable itaconic acid is synthesized by esterification. The structure is confirmed by ultraviolet spectroscopy, Fourier transform infrared spectroscopy, nuclear magnetic resonance spectroscopy (1H NMR, 13C NMR) and thermogravimetric analysis. The photopolymerization behaviour of the photoinitiator is investigated using photo-differential scanning calorimetry and compared with that of two commercial photoinitiators, HHMP (or photoinitiator 2959) and 1-hydroxycyclohexyl phenyl ketone (or photoinitiator 184). The results show that IAHHMP has a strong UV absorption capacity at 245~300 nm and can initiate polymerization of monomers containing a double bond. The relative migration of IAHHMP is less than that of the systems containing an HHMP or 1-hydroxycyclohexyl phenyl ketone photoinitiator. Therefore, IAHHMP is expected to have potential applications in more environmentally friendly materials, such as in food and medical packaging.","PeriodicalId":15318,"journal":{"name":"Journal of Chemical Research-s","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87192603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Catalytic degradation of CWAs with MOF-808 and PCN-222: Toward practical application MOF-808和PCN-222催化降解CWAs的研究进展

Journal of Chemical Research-s Pub Date : 2022-11-01 DOI: 10.1177/17475198221138061

Shaoxiong Wu, L. Wang, H. Zhu, Jing Liang, Liangqi Ge, Cong Li, Ting Miao, J. Li, Zhenxing Cheng

{"title":"Catalytic degradation of CWAs with MOF-808 and PCN-222: Toward practical application","authors":"Shaoxiong Wu, L. Wang, H. Zhu, Jing Liang, Liangqi Ge, Cong Li, Ting Miao, J. Li, Zhenxing Cheng","doi":"10.1177/17475198221138061","DOIUrl":"https://doi.org/10.1177/17475198221138061","url":null,"abstract":"Chemical warfare agents, such as nerve agents (GD and VX) and blister agents (HD), have strong toxicities to mankind. In recent years, zirconium-based metal-organic frameworks have been found to be attractive materials for chemical warfare agent degradation. Among them, metal-organic framework-808 (MOF-808) and porous coordination network-222 (PCN-222) were the best. However, few papers pay attention to their practical application. In this work, we prepared MOF-808 and PCN-222 using water phase and organic solvothermal methods, respectively. Their performance for the catalytic degradation of chemical warfare agents under practical decontamination conditions was studied. The results showed that MOF-808 displayed a high potency for catalytic hydrolysis of VX (10,000 mg L−1) in unbuffered solution. PCN-222 exhibited weaker reactivity with a half-life (t1/2) of 28.8 min. Their different performances might stem from the different connectivity of the Zr6 nodes and framework structures. The results illustrated that the hydrolysis of high-concentration GD required a strong alkaline buffer to neutralize the hydrolysis product of hydrofluoric acid (HF) to avoid catalyst poisoning. When H2O2 was used as the oxidant instead of O2, both zirconium-based metal-organic frameworks performed with effective catalytic potency for HD degradation without any special lighting and so was suitable for practical application, whereas the products obtained from HD, such as HDO2 and V-HDO2, still possessed vesicant toxicity. Overall, MOF-808 prepared via a water-phase synthesis performed with effective catalysis for the degradation of high-concentration VX, GD, and HD with t1/2 of < 0.5, 3.1 and 2.2 min, respectively, exhibiting its potential for practical applications.","PeriodicalId":15318,"journal":{"name":"Journal of Chemical Research-s","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88346100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Photophysical properties of furan-bridged dimeric boron-dipyrromethene derivatives (BODIPYs) 呋喃桥接二聚体硼-二芘衍生物(BODIPYs)的光物理性质

Journal of Chemical Research-s Pub Date : 2022-11-01 DOI: 10.1177/17475198221143738

Galam Jung, Namdoo Kim, S. Bae

引用次数: 0