Journal of Chemical Research-s最新文献

Synthesis of a new diarylhydrazone derivative and an evaluation of its in vitro biofilm inhibition and quorum sensing disruption along with a molecular docking study 一种新型二芳基腙衍生物的合成及其体外生物膜抑制和群体感应干扰的评价及分子对接研究

Journal of Chemical Research-s Pub Date : 2023-07-01 DOI: 10.1177/17475198231184603

S. Boudiba, A. N. Tamfu, K. Hanini, I. Selatnia, L. Boudiba, Ibtissam Saouli, P. Mosset, O. Ceylan, D. Egbe, A. Sid, R. Dinică

{"title":"Synthesis of a new diarylhydrazone derivative and an evaluation of its in vitro biofilm inhibition and quorum sensing disruption along with a molecular docking study","authors":"S. Boudiba, A. N. Tamfu, K. Hanini, I. Selatnia, L. Boudiba, Ibtissam Saouli, P. Mosset, O. Ceylan, D. Egbe, A. Sid, R. Dinică","doi":"10.1177/17475198231184603","DOIUrl":"https://doi.org/10.1177/17475198231184603","url":null,"abstract":"Molecules that target quorum sensing and biofilm inhibition are useful antimicrobials. In this regard, a new diarylhydrazone was synthesized and characterized using infrared, high-resolution mass spectrometry and nuclear magnetic resonance experiments as N-[( E)-4-bromo-2,5-diheptyloxybenzylideneamino]-2,4-dinitroaniline (BHBANA). Minimal inhibitory concentrations (MICs) vary from 0.625 to 2.5 mg mL−1. This compound was screened in vitro for its inhibition of quorum sensing–mediated violacein production by Chromobacterium violaceum CV12472 at MIC and sub-MIC and showed percentage inhibition varying from 100% at MIC to 5.7% ± 0.2% at MIC/32. Against Chromobacterium violaceum CV026, BHBANA exhibited anti-quorum-sensing zone diameters of 10.5 ± 0.3 mm and 7.0 ± 0.1 mm at MIC and MIC/2, respectively. BHBANA shows concentration-dependent inhibition of swarming motility on flagellated Pseudomonas aeruginosa PA01 with the highest % inhibition of 28.30% ± 0.50% μg mL−1 at MIC. The product inhibits biofilm formation, with the best biofilm inhibition being observed against Staphylococcus aureus varying from 72.24% ± 0.86% (MIC) to 09.82% ± 0.10% (MIC/8). Molecular docking studies carried out utilizing the Schrodinger software identified interactions between BHBANA and different receptor compartments of Chromobacterium violaceum, which can block pathogenic gene expression. The results suggest the potential of BHBANA in reducing microbial virulence.","PeriodicalId":15318,"journal":{"name":"Journal of Chemical Research-s","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89212038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A study of mono-, di- and tri-tosylated amines: An unexpected sulfonamide 单、二、三甲基化胺的研究:一种意想不到的磺胺

Journal of Chemical Research-s Pub Date : 2023-07-01 DOI: 10.1177/17475198231194866

M. Plater, W. Harrison

引用次数: 0

A thermoregulated phase-transfer ruthenium nanocatalyst for the atmospheric hydrogenation of α,β-unsaturated ketones 用于α，β-不饱和酮常压加氢的热调节相转移钌纳米催化剂

Journal of Chemical Research-s Pub Date : 2023-07-01 DOI: 10.1177/17475198231189838

Bin Gao, Yanhua Wang

引用次数: 0

Ni(II) and Pd(II) complexes bearing novel chiral bis(β-ketoamino) ligand and their catalytic activity toward copolymerization of norbornene and polar norbornene derivatives 新型手性双(β-酮氨基)配体Ni(II)和Pd(II)配合物对降冰片烯及其极性降冰片烯衍生物共聚的催化活性

Journal of Chemical Research-s Pub Date : 2023-07-01 DOI: 10.1177/17475198231187525

Wanyun Liu, Ping Huo, Lin Yuan, Bowen Zhao, Junying Ge

引用次数: 0

One-pot, simple, and facile synthesis of 4-(3-benzylbenzo[d]thiazol-2(3H)-ylidene)-cyclohexa-2,5-dien-1-one derivatives via a novel three-component reaction 一锅简易合成4-(3-苄基苯并[d]噻唑-2(3H)-酰基)-环己-2,5-二烯-1- 1衍生物

Journal of Chemical Research-s Pub Date : 2023-07-01 DOI: 10.1177/17475198231185553

M. Nassiri

引用次数: 0

An effective calix[4]arene-based adsorbent for tetracycline removal from water systems: Kinetic, isotherm, and thermodynamic studies 一种有效的杯[4]芳烃基吸附剂去除水中四环素:动力学、等温线和热力学研究

Journal of Chemical Research-s Pub Date : 2023-07-01 DOI: 10.1177/17475198231187600

Waad M Al-Tawarh, R. Altarawneh, Salah A Al-Trawneh, S. Alshahateet, Samir A. Al-taweel

{"title":"An effective calix[4]arene-based adsorbent for tetracycline removal from water systems: Kinetic, isotherm, and thermodynamic studies","authors":"Waad M Al-Tawarh, R. Altarawneh, Salah A Al-Trawneh, S. Alshahateet, Samir A. Al-taweel","doi":"10.1177/17475198231187600","DOIUrl":"https://doi.org/10.1177/17475198231187600","url":null,"abstract":"This study aims to investigate the adsorption characteristics of tetracycline from polluted waters using C-4-hydroxyphenylcalix[4]resorcinarene as an adsorbent. The adsorptive efficiency of C-4-hydroxyphenylcalix[4]resorcinarene is optimized by adjusting various operational parameters such as the adsorbent dosage, the pH, the contact time, the temperature, and the initial adsorbate concentration. The most efficient remediation is 96% at 10.0 mg/L tetracycline as the initial concentration, 0.05 mg/L C-4-hydroxyphenylcalix[4]resorcinarene, a contact time of 30 min, pH 5.6, and ambient temperature. The adsorption ability of C-4-hydroxyphenylcalix[4]resorcinarene toward tetracycline is also investigated in water with different characteristics, including solutions with and without the addition of background salts. The results show that C-4-hydroxyphenylcalix[4]resorcinarene can effectively remove tetracycline from aqueous solutions with an adsorption capacity of ca. 36.9 mg/g. The study also finds that the removal process followed pseudo-second order kinetics and Freundlich isotherm models. Moreover, the adsorption is spontaneous and exothermic, suggesting a thermodynamically favorable chemisorption process. In addition, the optimized method is successfully applied to remove tetracycline from various real natural water systems.","PeriodicalId":15318,"journal":{"name":"Journal of Chemical Research-s","volume":"124 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76174297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lignans and some other non-alkaloid compounds from the stem bark of Zanthoxylum rhetsa and their biological activities 花椒茎皮中木脂素等非生物碱类化合物及其生物活性研究

Journal of Chemical Research-s Pub Date : 2023-07-01 DOI: 10.1177/17475198231185704

T. T. Tuyen, Pham Cao Bach, Do Huu Nghi, Pham Minh Quan, P. H. Hong Minh, N. H. Hong Van

{"title":"Lignans and some other non-alkaloid compounds from the stem bark of Zanthoxylum rhetsa and their biological activities","authors":"T. T. Tuyen, Pham Cao Bach, Do Huu Nghi, Pham Minh Quan, P. H. Hong Minh, N. H. Hong Van","doi":"10.1177/17475198231185704","DOIUrl":"https://doi.org/10.1177/17475198231185704","url":null,"abstract":"Four lignans, asarinin (1), horsfieldin (2), 5-(4-(3,4,5-trimethoxyphenyl)hexahydrofuro[3,4-c]furan-1-yl)benzo[d][1,3]dioxole (3), 5-(4-(3,5-dimethoxyphenyl)hexahydrofuro[3,4-c]furan-1-yl)benzo[d][1,3]dioxole (4), and four non-alkaloid compounds, piperonylic acid (5), hesperidin (6), syringin (7), and β-sitosterol (8) were isolated from the stem bark of Zanthoxylum rhetsa grown in Vietnam. Their chemical structures were elucidated by spectroscopic analysis and compared with the references. Except for compound 6, all the remaining compounds (1–5, 7, and 8) were isolated for the first time from Z. rhetsa. The isolated compounds were tested for their cytotoxic activity against three human cancer cell lines, LU-1, Hep-G2, and KB. Compound 5 showed moderate cytotoxic activity against all three cell lines with IC50 values ranging from 48.13 to 49.06 µg mL−1. Notably, compound 6 demonstrated selective cytotoxicity against LU-1, Hep-G2, and KB cancer cell lines (IC50 66.48–67.41 µg mL−1) while non-toxic toward normal Vero cell. Compound 6 also exhibited its ability to inhibit main protease (Mpro) enzyme in vitro with an IC50 value of 55.49 µg mL−1 and in silico with the binding affinity toward targeted protein of −14.36 kcal mol−1.","PeriodicalId":15318,"journal":{"name":"Journal of Chemical Research-s","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84148447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation of ZrO2/Na-β and ZrO2/H-β catalysts and their catalytic performance for the Meerwein–Ponndorf–Verley reaction of cyclohexanone and isopropanol ZrO2/Na-β和ZrO2/H-β催化剂的制备及其对环己酮与异丙醇Meerwein-Ponndorf-Verley反应的催化性能

Journal of Chemical Research-s Pub Date : 2023-07-01 DOI: 10.1177/17475198231185064

Lin-hui Dong, Fan-fei Meng, Li-ye Liu, Jun Qiu

{"title":"Preparation of ZrO2/Na-β and ZrO2/H-β catalysts and their catalytic performance for the Meerwein–Ponndorf–Verley reaction of cyclohexanone and isopropanol","authors":"Lin-hui Dong, Fan-fei Meng, Li-ye Liu, Jun Qiu","doi":"10.1177/17475198231185064","DOIUrl":"https://doi.org/10.1177/17475198231185064","url":null,"abstract":"ZrO2/Na-β and ZrO2/H-β catalysts are prepared by the reflux impregnation method and are applied to the Meerwein–Ponndorf–Verley reduction of cyclohexanone and isopropanol. The catalysts are characterized by X-ray diffraction, scanning electron microscopy-energy dispersive spectrum, temperature-programmed desorption of ammonia, N2 isothermal adsorption and desorption, and inductively coupled plasma mass spectrometry. The products are identified by gas chromatography‒mass spectrometry and analyzed by gas chromatography. The experimental results showed that ZrO2/H-β exhibits higher catalytic activity for the above Meerwein–Ponndorf–Verley reduction because ZrO2/H-β has both Zr4+ and Al3+ ion acid centers, which provide the moderately strong acid needed for the reaction. Under optimized conditions, ZrO2/H-β(6) is used as the catalyst, and the conversion rate of cyclohexanone was 92.0% as determined by the area-normalized calculation based on cyclohexanone. The catalyst can be regenerated by programmed heating calcination. The conversion rate of cyclohexanone decreased to 79.4% after five recycling cycles, and its service life needs further study to be improved.","PeriodicalId":15318,"journal":{"name":"Journal of Chemical Research-s","volume":"230 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72432034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A study on the modification of nano-barium sulfate using a grafting method 接枝法改性纳米硫酸钡的研究

Journal of Chemical Research-s Pub Date : 2023-07-01 DOI: 10.1177/17475198231195819

Yue Liu, Yan Li, Guo-en Li

引用次数: 0

Spectroscopic and DFT study of tris(β-diketonato)cobalt(III) complexes 三(β-双酮ato)钴(III)配合物的光谱和DFT研究

Journal of Chemical Research-s Pub Date : 2023-07-01 DOI: 10.1177/17475198231184788

L. Twigge, J. Conradie, E. Erasmus

{"title":"Spectroscopic and DFT study of tris(β-diketonato)cobalt(III) complexes","authors":"L. Twigge, J. Conradie, E. Erasmus","doi":"10.1177/17475198231184788","DOIUrl":"https://doi.org/10.1177/17475198231184788","url":null,"abstract":"Nuclear magnetic resonance measurements confirm that, as expected, the mer isomer of tris(β-diketonato) cobalt(III) complexes is more stable ( mer isomers are more stable because they are less affected by steric hindrance and they have lower dipoles). An excess of the mer isomer or only the mer isomer is experimentally observed. The existence of both fac and mer isomers is predicted by density functional theory calculations. At room temperature, the nuclear magnetic resonance peaks of phenyl-containing mer complexes are broad due to the intermediate rotation of bulky phenyl groups resulting in only the average orientation of the non-equivalent protons in the mer complexes. However, upon heating to 55 °C (thus speeding up the rotation) or cooling to −50 °C (slowing down the rotation), this broad peak is resolved into three sets of carbon peaks appearing in the 13C NMR spectrum, as well as splitting of the 1H NMR peaks for the non-equivalent protons in the mer isomer. In solid-state 13C NMR the aromatic rings do not rotate, resulting in the splitting of all the 13C NMR peaks. Two sets of well-defined peaks are observed for the fluorine-containing compound [Co(CF3COCHCOCPh)3] in both the 13C and 19F NMR spectra, indicating that both the fac and mer isomers are present with a ratio of fac:mer = 0.1:1. The X-ray photoelectron spectroscopy measured binding energy of the Co 2p3/2 photoelectron lines are influenced by the subtle electronic (electron-donating or electron-withdrawing) properties of the R groups on the β-diketonato ligands. Various relationships are established between the binding energy of Co 2p3/2 and several physical and density functional theory–calculated properties, confirming good electronic communication (the measurable electronic effect that a molecular fragment has on the physical properties of another molecular fragment in the molecule) of the substituent groups through the pseudo aromatic system of the β-diketonato backbones to the metal.","PeriodicalId":15318,"journal":{"name":"Journal of Chemical Research-s","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73769047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0