Journal of Chemical Research-s最新文献

Enhanced photocatalytic degradation efficiency of ciprofloxacin by CuAl layered double hydroxide materials CuAl层状双氧根材料提高环丙沙星光催化降解效率

Journal of Chemical Research-s Pub Date : 2025-05-01 DOI: 10.1177/17475198251344773

Van Nhuong Vu, Linh Thi My Hoang, Thi Ha Thanh Pham, Thi Kim Ngan Tran

{"title":"Enhanced photocatalytic degradation efficiency of ciprofloxacin by CuAl layered double hydroxide materials","authors":"Van Nhuong Vu, Linh Thi My Hoang, Thi Ha Thanh Pham, Thi Kim Ngan Tran","doi":"10.1177/17475198251344773","DOIUrl":"https://doi.org/10.1177/17475198251344773","url":null,"abstract":"Sets of nCuAl-LDH layered double hydroxide samples were successfully synthesized by the co-precipitation method, using precursors such as Al(NO 3 ) 3 , Cu(NO 3 ) 2 , and Na 2 CO 3 salts to provide <mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" display=\"inline\" overflow=\"scroll\"> <mml:mrow> <mml:mi>C</mml:mi> <mml:msubsup> <mml:mi>O</mml:mi> <mml:mn>3</mml:mn> <mml:mrow> <mml:mn>2</mml:mn> <mml:mo>−</mml:mo> </mml:mrow> </mml:msubsup> </mml:mrow> </mml:math> ion in the interlayers. The synthesized material samples were characterized by modern physical analysis methods: XRD patterns, SEM images, EDX spectra, UV-Vis DRS spectra. The results of the characterization analysis showed that the 2CuAl-LDH, 3-CuAl-LDH samples had a lamellar structure similar to hydrotalcite. The synthesized samples with high Cu:Al molar ratio (4-CuAl-LDH, 5-CuAl-LDH, 6-CuAl-LDH) had a strong decrease in the layered double structure. The CuAl-LDH material samples had a strong shift to the visible light region, the band gap energy sharply reduced from 3.52 eV (MgAlH) to 1.44 eV (3CuAl-LDH) and 0.95 eV (2CuAl-LDH). The results of the investigation on the photocatalytic degradation of ciprofloxacin showed that two material samples 2CuAl-LDH and 3CuAl-LDH had the best CIP degradation ability. The CIP degradation efficiency with concentrations of 10, 25, 40, 50 ppm reached 93.3, 92.2, 90.2, 89.2% using a 30 W LED light source. In addition, the optimal environmental for CIP degradation was the initial pH value of the 50 ppm CIP solution (pH value as 5.8).","PeriodicalId":15318,"journal":{"name":"Journal of Chemical Research-s","volume":"49 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147333597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Identification of lead small molecules for the design and development of potent severe acute respiratory syndrome coronavirus 2 main protease inhibitors 鉴定铅小分子用于设计研制强效的严重急性呼吸综合征冠状病毒2主要蛋白酶抑制剂

Journal of Chemical Research-s Pub Date : 2025-03-01 DOI: 10.1177/17475198251326083

Elvis Awuni

{"title":"Identification of lead small molecules for the design and development of potent severe acute respiratory syndrome coronavirus 2 main protease inhibitors","authors":"Elvis Awuni","doi":"10.1177/17475198251326083","DOIUrl":"https://doi.org/10.1177/17475198251326083","url":null,"abstract":"The repercussions of the COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are catastrophic, and the world has yet to achieve full recovery. Several inhibitors targeting SARS-CoV-2 main protease are experiencing diminished efficacy owing to resistance-inducing mutations. The current situation implies that the quest to find potent and resilient SARS-CoV-2 main protease drugs to overcome resistance must be a continuous effort. Here, multiple receptor virtual screening and molecular dynamics (MD) simulation techniques were employed to identify novel binders from an integrated small-molecule database as leads for the discovery, design, and development of antivirals immune to resistance by SARS-CoV-2 main protease. The small-molecule database was initially screened separately against five SARS-CoV-2 main protease structures with different substrate-binding site conformations using the GOLD program, after which the fitness score of a control compound was used as the cutoff to create a shortlist of potential hits in each case. Then, 21 compounds at the intersection of all five shortlists were selected as virtual screening hits. The hits were subjected to MD simulations, identifying four novel compounds capable of remaining bound to SARS-CoV-2 main protease for up to 100 ns. Analysis of the mode of binding and interactions between each of the four compounds and SARS-CoV-2 main protease revealed that the compounds fit better into the conserved subpockets of the substrate-binding site than the control and interact with important amino acid residues. Conjointly, MD simulations, binding energy, and toxicity analysis results further demonstrated that the compounds are promising leads for the discovery, design, and development of potent drugs to augment the fight against SARS-CoV-2 main protease resistance.","PeriodicalId":15318,"journal":{"name":"Journal of Chemical Research-s","volume":"49 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147330486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel thermoregulated phase-separable Pt nanocatalyst for selective hydrogenation of quinoline and its derivatives 一种用于喹啉及其衍生物选择性加氢的新型热调节相分离铂纳米催化剂

Journal of Chemical Research-s Pub Date : 2025-01-01 DOI: 10.1177/17475198241311697

Mingyang Liu, Yanhua Wang

引用次数: 0

Design and synthesis of ferulic acid-based aldose reductase inhibitors as hypoglycemic agents 阿魏酸醛糖还原酶抑制剂的设计与合成

Journal of Chemical Research-s Pub Date : 2025-01-01 DOI: 10.1177/17475198241311788

Yulan Zhu, Yuhang Ding

引用次数: 0

Synthesis research on the herbicide safe agent Furilazole 除草剂安全剂呋喃唑的合成研究

Journal of Chemical Research-s Pub Date : 2024-11-01 DOI: 10.1177/17475198241299586

Yinuo Wang, Yan Liang, Yutong Li, Yue Zhang, Haiwen Song, Aibing Ke

引用次数: 0

Design and synthesis of novel curcumin derivatives as potent PDE4 inhibitors for the treatment of depression 设计与合成新型姜黄素衍生物作为有效的PDE4抑制剂治疗抑郁症

Journal of Chemical Research-s Pub Date : 2024-11-01 DOI: 10.1177/17475198241304588

Haodong Zhou, Yulan Zhu, Xianfeng Huang

引用次数: 2

One-step preparation and characterization of an imidazolium-contained fluorocarbon surfactant and its potential application in aqueous film-forming foam 含咪唑氟碳表面活性剂的一步法制备、表征及其在水成膜泡沫中的应用前景

Journal of Chemical Research-s Pub Date : 2024-09-01 DOI: 10.1177/17475198241275875

Hao Wang, Yicheng Zhang, Fangyu Gao, Xinhua Zhu, Quanyi Liu, Xuhong Jia

{"title":"One-step preparation and characterization of an imidazolium-contained fluorocarbon surfactant and its potential application in aqueous film-forming foam","authors":"Hao Wang, Yicheng Zhang, Fangyu Gao, Xinhua Zhu, Quanyi Liu, Xuhong Jia","doi":"10.1177/17475198241275875","DOIUrl":"https://doi.org/10.1177/17475198241275875","url":null,"abstract":"Preparing fluorocarbon surfactant for aqueous film-forming foam is a complex process. Overcoming steric hindrance when introducing imidazolium to the fluorocarbon chain is a key challenge. In this significant work, we proposed a simple one-step route to prepare imidazolium-contained fluorocarbon surfactant under mild conditions. The FT-IR, 1 H NMR, 13 C NMR, MS, and TG technologies characterized the imidazolium-contained fluorocarbon surfactant by analyzing functional groups, molecular weight, and thermal stability. An equimolar mixture of imidazolium-contained fluorocarbon surfactant and C 6 H 13 NaO 3 S demonstrated high surface activity, enabling the foam to spread effectively on commercial fuels. The spreading coefficient of foam on n-cyclohexane met the US Military Specification. Coordinatively, the foam drained in time to maintain the stability and completeness of the aqueous layer, with a moderate 25% drainage time of 317 s and a proper foam expansion ratio of 10.5. In extinguishing experiments, the imidazolium-contained fluorocarbon surfactant/C 6 H 13 NaO 3 mixture extinguished test fires in 65 s, suggesting an essential potential in the aqueous film-forming foam formula.","PeriodicalId":15318,"journal":{"name":"Journal of Chemical Research-s","volume":"48 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147921461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Preparation and performance of magnetic microspheres encapsulating Fe ₃ O ₄ @SiO ₂ nanoparticles 包封二氧化铁纳米颗粒的磁性微球制备及性能研究

Journal of Chemical Research-s Pub Date : 2024-09-01 DOI: 10.1177/17475198241285635

Liyuan Zhang, Xuewen Bai, Kai Zou, Linlin Zhu

引用次数: 2

Investigation on improving mechanical property of silicone rubber by employing functionalized nanosilica 功能化纳米二氧化硅改善硅橡胶力学性能的研究

Journal of Chemical Research-s Pub Date : 2024-05-01 DOI: 10.1177/17475198241260559

Liyuan Zhang, Hongfa Zhao, Linlin Zhu

引用次数: 2

Synthesis of a new diarylhydrazone derivative and an evaluation of its in vitro biofilm inhibition and quorum sensing disruption along with a molecular docking study 一种新型二芳基腙衍生物的合成及其体外生物膜抑制和群体感应干扰的评价及分子对接研究

Journal of Chemical Research-s Pub Date : 2023-07-01 DOI: 10.1177/17475198231184603

S. Boudiba, A. N. Tamfu, K. Hanini, I. Selatnia, L. Boudiba, Ibtissam Saouli, P. Mosset, O. Ceylan, D. Egbe, A. Sid, R. Dinică

{"title":"Synthesis of a new diarylhydrazone derivative and an evaluation of its in vitro biofilm inhibition and quorum sensing disruption along with a molecular docking study","authors":"S. Boudiba, A. N. Tamfu, K. Hanini, I. Selatnia, L. Boudiba, Ibtissam Saouli, P. Mosset, O. Ceylan, D. Egbe, A. Sid, R. Dinică","doi":"10.1177/17475198231184603","DOIUrl":"https://doi.org/10.1177/17475198231184603","url":null,"abstract":"Molecules that target quorum sensing and biofilm inhibition are useful antimicrobials. In this regard, a new diarylhydrazone was synthesized and characterized using infrared, high-resolution mass spectrometry and nuclear magnetic resonance experiments as N-[( E)-4-bromo-2,5-diheptyloxybenzylideneamino]-2,4-dinitroaniline (BHBANA). Minimal inhibitory concentrations (MICs) vary from 0.625 to 2.5 mg mL−1. This compound was screened in vitro for its inhibition of quorum sensing–mediated violacein production by Chromobacterium violaceum CV12472 at MIC and sub-MIC and showed percentage inhibition varying from 100% at MIC to 5.7% ± 0.2% at MIC/32. Against Chromobacterium violaceum CV026, BHBANA exhibited anti-quorum-sensing zone diameters of 10.5 ± 0.3 mm and 7.0 ± 0.1 mm at MIC and MIC/2, respectively. BHBANA shows concentration-dependent inhibition of swarming motility on flagellated Pseudomonas aeruginosa PA01 with the highest % inhibition of 28.30% ± 0.50% μg mL−1 at MIC. The product inhibits biofilm formation, with the best biofilm inhibition being observed against Staphylococcus aureus varying from 72.24% ± 0.86% (MIC) to 09.82% ± 0.10% (MIC/8). Molecular docking studies carried out utilizing the Schrodinger software identified interactions between BHBANA and different receptor compartments of Chromobacterium violaceum, which can block pathogenic gene expression. The results suggest the potential of BHBANA in reducing microbial virulence.","PeriodicalId":15318,"journal":{"name":"Journal of Chemical Research-s","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89212038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2