Synthesis of 3-(2-oxopropyl)-2-arylisoindolinone derivatives via a three-component reaction of diaryliodonium salts with 2-formylbenzonitriles and phenylacetylenes

Journal of Chemical Research-s Pub Date : 2022-11-01 DOI:10.1177/17475198211063799

Yang Li, Yuan Li, Haiyang Fei, Rui Kong, Zhen-Wen Yu, Liu He

引用次数: 0

Abstract

A copper-catalyzed multicomponent cascade cyclization using readily available substrates, including 2-formylbenzonitriles, phenylacetylenes, and diaryliodonium salts, is achieved. A broad reaction scope is presented with good functional group compatibility, giving rise to a range of 3-(2-oxopropyl)-2-arylisoindolinones in moderate to good yields.

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二芳基碘盐与2-甲酰苯并腈和苯乙炔三组分反应合成3-(2-氧丙基)-2-芳基异吲哚酮衍生物

铜催化的多组分级联环化使用容易获得的底物，包括2-甲酰苯并腈，苯乙炔和二芳基碘鎓盐，被实现。反应范围广，官能团相容性好，产率中高的3-(2-氧丙基)-2-芳基异吲哚酮。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Chemical Research-s 化学科学, 有机化学, 有机合成

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Chemical Research is a peer reviewed journal that publishes full-length review and research papers in all branches of experimental chemistry. The journal fills a niche by also publishing short papers, a format which favours particular types of work, e.g. the scope of new reagents or methodology, and the elucidation of the structure of novel compounds. Though welcome, short papers should not result in fragmentation of publication, they should describe a completed piece of work. The Journal is not intended as a vehicle for preliminary publications. The work must meet all the normal criteria for acceptance as regards scientific standards. Papers that contain extensive biological results or material relating to other areas of science may be diverted to more appropriate specialist journals. Areas of coverage include: Organic Chemistry; Inorganic Chemistry; Materials Chemistry; Crystallography; Computational Chemistry.