Journal of biochemistry最新文献_第4页

Characterization of p16-positive stromal cells in age-related cardiac disorders. p16阳性基质细胞在年龄相关性心脏疾病中的表征

IF 2.4 4区生物学

Journal of biochemistry Pub Date : 2026-06-01 DOI: 10.1093/jb/mvag013

Taiki Morimura, Teh-Wei Wang, Satoshi Kawakami, Makoto Nakanishi

{"title":"Characterization of p16-positive stromal cells in age-related cardiac disorders.","authors":"Taiki Morimura, Teh-Wei Wang, Satoshi Kawakami, Makoto Nakanishi","doi":"10.1093/jb/mvag013","DOIUrl":"10.1093/jb/mvag013","url":null,"abstract":"The heart undergoes structural alterations, including fibrosis and cardiomyocyte hypertrophy with age. These alterations are accompanied by functional decline, resulting in heart failure. Although cardiac stromal cells such as fibroblasts and macrophages are known to play a role in age-related cardiac changes, specific subsets of these cells may have a more pronounced effect on the development of these alterations. In this study, we analyzed p16, a marker of senescence,-positive (p16+) cells in cardiac fibrosis by single-cell RNA sequencing of aged p16-Tom mice, in which p16+ cells can be labelled in the presence of tamoxifen. We found that TGF-β signalling were significantly enriched in the transcriptome of p16+ fibroblasts compared with p16- fibroblasts. Besides, BMP4 was upregulated in p16+ fibroblasts. This activation potentially promoted the expression of collagen genes such as Col4a1 and Col5a3. Selective elimination of p16+ fibroblasts ameliorated cardiac fibrosis in aged p16-Col1a2-LRTD mice, with levels comparable to those observed in young mice. These findings suggest that p16+ fibroblasts play a critical role in age-associated cardiac fibrosis. We further demonstrate the potential use of transcriptomic signatures of p16+ fibroblasts to identify human fibroblast subsets causing age-related cardiac diseases such as dilated cardiomyopathy.","PeriodicalId":15234,"journal":{"name":"Journal of biochemistry","volume":" ","pages":"413-425"},"PeriodicalIF":2.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13201264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146220104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary on 'the ATPase activity of ABCA1 is increased by cholesterol in the presence of anionic lipids'. 评论“阴离子脂质存在时，胆固醇增加ABCA1的atp酶活性”。

IF 2.4 4区生物学

Journal of biochemistry Pub Date : 2026-06-01 DOI: 10.1093/jb/mvag003

Akira Kazaoka, Keiichiro Okuhira

引用次数: 0

Targeting the CCL2-CCR2 axis in cancer: insights into in vitro screening and humanized mice. 在癌症中靶向CCL2-CCR2轴：来自体外筛选和人源化小鼠的见解。

IF 2.4 4区生物学

Journal of biochemistry Pub Date : 2026-06-01 DOI: 10.1093/jb/mvag009

Yanjun Chen, Midori Shimada

{"title":"Targeting the CCL2-CCR2 axis in cancer: insights into in vitro screening and humanized mice.","authors":"Yanjun Chen, Midori Shimada","doi":"10.1093/jb/mvag009","DOIUrl":"10.1093/jb/mvag009","url":null,"abstract":"An immunosuppressive tumor microenvironment that facilitates cancer progression is an important challenge in combating the disease. The CCL2-CCR2 axis is a primary facilitator in this process, facilitating the recruitment of CCR2-positive myeloid cells, including M-MDSCs and TAMs, to tumor and metastatic locations. CCR2 is also expressed on tumor cells and regulatory T cells, further enhancing cancer cell motility and immune suppression. Inhibition of this system through genetic deletion or small-molecule inhibitors significantly reduces primary tumor and metastasis in preclinical models, highlighting CCR2 as a promising therapeutic target. Although several CCR2 inhibitors have entered clinical trials, differences in their potency and the limited predictability of murine models have hampered clinical translation. The current work by Sugiyama et al. carefully evaluated 10 human CCR2 antagonists, identifying MK0812 as the most effective inhibitor. Using human CCR2B knock-in mice, they established a practical platform for evaluating CCR2-targeted drugs with direct relevance to human cancer therapy, highlighting the importance of humanized models for translational immuno-oncology.","PeriodicalId":15234,"journal":{"name":"Journal of biochemistry","volume":" ","pages":"375-378"},"PeriodicalIF":2.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polysulfides at the core of bacterial sulfur metabolism. 多硫化物是细菌硫代谢的核心。

IF 2.4 4区生物学

Journal of biochemistry Pub Date : 2026-06-01 DOI: 10.1093/jb/mvag015

Takayuki Shimizu

{"title":"Polysulfides at the core of bacterial sulfur metabolism.","authors":"Takayuki Shimizu","doi":"10.1093/jb/mvag015","DOIUrl":"10.1093/jb/mvag015","url":null,"abstract":"Polysulfides have emerged as key intermediates that organize sulfur metabolism, redox regulation and environmental adaptation in bacteria. Rather than representing minor side products, polysulfides form a dynamic chemical pool that links sulfide utilization, sulfur storage and regulatory signaling. This review provides an integrated overview of polysulfide-centered sulfur metabolism in bacteria, highlighting how polysulfides arise through multiple metabolic routes and are subsequently processed, redistributed or stored depending on physiological context. Particular emphasis is placed on the dual roles of polysulfides as both metabolic intermediates and regulatory signals, enabling cells to coordinate sulfur flux with transcriptional control and redox homeostasis. The accumulation of elemental sulfur is discussed as a context-dependent outcome of polysulfide chemistry, functioning either as a transient intermediate during sulfide oxidation or as a regulated sulfur reserve under nutrient limitation. By reinterpreting classical studies of sulfur metabolism alongside recent biochemical, genetic and genomic advances, this review underscores the ubiquity and functional importance of polysulfides in bacterial physiology. Collectively, these insights support a unifying view in which polysulfides occupy a central position in bacterial sulfur metabolism, bridging ancient sulfur-based bioenergetics with modern regulatory networks that ensure metabolic flexibility and environmental resilience.","PeriodicalId":15234,"journal":{"name":"Journal of biochemistry","volume":" ","pages":"383-391"},"PeriodicalIF":2.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146219083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urinary excretion of nonsulfated HNK-1 glycans is associated with renal dysfunction. 尿中排泄非硫酸化的HNK-1聚糖与肾功能障碍有关。

IF 2.4 4区生物学

Journal of biochemistry Pub Date : 2026-05-11 DOI: 10.1093/jb/mvag007

Hajime Okayama, Nanako Iikura, Daisuke Takakura, Sayaka Abe, Anna Sahara, Shunpei Toyoda, Hitomi Kitano, Katsuaki Higashi, Naoki Nakagawa, Motohiro Nonaka, Nana Kawasaki, Shogo Oka, Jyoji Morise

{"title":"Urinary excretion of nonsulfated HNK-1 glycans is associated with renal dysfunction.","authors":"Hajime Okayama, Nanako Iikura, Daisuke Takakura, Sayaka Abe, Anna Sahara, Shunpei Toyoda, Hitomi Kitano, Katsuaki Higashi, Naoki Nakagawa, Motohiro Nonaka, Nana Kawasaki, Shogo Oka, Jyoji Morise","doi":"10.1093/jb/mvag007","DOIUrl":"10.1093/jb/mvag007","url":null,"abstract":"Nonsulfated human natural killer-1 (nsHNK-1) glycan is a trisaccharide biosynthesized by β-1,3-glucuronyltransferase 2 (GlcAT-S) and expressed in the mouse kidney, especially the apical membrane of proximal tubules. Although such apical membrane proteins are known to shed into urine, the presence and significance of urinary nsHNK-1 glycans have remained unexplored. Here, we demonstrated that nsHNK-1 glycan is detectable in mouse urine and identified its major carrier as meprin A subunit alpha (MEP1A), a metalloprotease enriched at the apical membrane of proximal tubules and known to be excreted into urine. Mass spectrometry revealed nsHNK-1 glycosylation at four sites on MEP1A, with the highest occupancy at Asn221 in the catalytic domain. In GlcAT-S knockout mice, urinary MEP1A lacked the nsHNK-1 glycan and exhibited reduced enzymatic activity, suggesting nsHNK-1 glycosylation has a functional contribution. Induced tubular injury decreased urinary MEP1A-associated nsHNK-1 levels, following a similar pattern to reduced MEP1A-associated nsHNK-1 levels in the kidney. In contrast, glomerular injury resulted in increased MEP1A-associated nsHNK-1 expression in the kidney, accompanied by elevated urinary nsHNK-1 levels. These findings suggest that urinary nsHNK-1 levels differentially reflect renal dysfunction and may serve as a novel biomarker of kidney function.","PeriodicalId":15234,"journal":{"name":"Journal of biochemistry","volume":" ","pages":"329-339"},"PeriodicalIF":2.4,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146105630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chimeric Fab incorporating the IgM Cμ1 domain: insights into physicochemical properties. 结合IgM Cμ1结构域的嵌合Fab：物理化学性质的见解。

IF 2.4 4区生物学

Journal of biochemistry Pub Date : 2026-05-11 DOI: 10.1093/jb/mvag008

Rara Sugimoto, Masato Kiyoshi, Hitomi Nakamura, Naoko Oda-Ueda, Akiko Ishii-Watabe, Takatoshi Ohkuri

{"title":"Chimeric Fab incorporating the IgM Cμ1 domain: insights into physicochemical properties.","authors":"Rara Sugimoto, Masato Kiyoshi, Hitomi Nakamura, Naoko Oda-Ueda, Akiko Ishii-Watabe, Takatoshi Ohkuri","doi":"10.1093/jb/mvag008","DOIUrl":"10.1093/jb/mvag008","url":null,"abstract":"Fab has been extensively studied to elucidate the structural and physicochemical principles underlying antigen recognition. While most investigations have focused on IgG-derived Fabs, comparatively little is known about those from other isotypes. To investigate the role of the IgM constant domain Cμ1, we engineered a chimeric Fab (Cμ1Fab) in which the CH1 domain of adalimumab Fab (IgG1) was replaced by the human IgM Cμ1 domain. Cμ1Fab was expressed in CHO cells and its physicochemical properties were evaluated. SDS-PAGE analysis with or without PNGase F treatment demonstrated that the N166-N167-S168 motif was N-glycosylated. SPR analysis demonstrated that Cμ1Fab retained antigen-binding activity comparable to that of the wild-type Fab, and elimination of the glycosylation motif (N166A) did not alter binding affinity. Notably, N-linked glycosylation within the Cμ1 domain suppressed aggregation, whereas the N166A variant showed marked aggregation. DSC further revealed that the glycosylation affected thermal stability. The melting temperature (Tm) of the N166A variant was 60.5°C, substantially lower than that of the Cμ1Fab (Tm = 66.0°C), although Tm of the wild-type Fab was 75.2°C. Collectively, these findings establish the critical role of native Cμ1 N-linked glycosylation in Fab stability, offering new insights for antibody engineering.","PeriodicalId":15234,"journal":{"name":"Journal of biochemistry","volume":" ","pages":"341-349"},"PeriodicalIF":2.4,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The eIF5-mimic protein 5MP1: a regulator of translation stringency and a multifaceted oncogene. eif5模拟蛋白5MP1：翻译严格性的调节因子和一个多方面的癌基因。

IF 2.4 4区生物学

Journal of biochemistry Pub Date : 2026-05-11 DOI: 10.1093/jb/mvag010

Abhineet Banerjee, Grant Brooke, Susumu Ishiguro, Katsura Asano

{"title":"The eIF5-mimic protein 5MP1: a regulator of translation stringency and a multifaceted oncogene.","authors":"Abhineet Banerjee, Grant Brooke, Susumu Ishiguro, Katsura Asano","doi":"10.1093/jb/mvag010","DOIUrl":"10.1093/jb/mvag010","url":null,"abstract":"Accurate initiation of eukaryotic translation is essential for proteome integrity, yet the process is intrinsically challenged by the potential use of non-AUG start codons. The eIF5-mimic protein 5MP1 (also known as BZW2) has emerged as a pivotal regulator that enhances stringency in start codon selection by competing with eIF5 and eIF2B for binding to eIF2 and eIF3. This competition suppresses non-AUG and repeat-associated non-AUG (RAN) translation and remodels the dynamics of the scanning preinitiation complex. Beyond its biochemical role, accumulating evidence since the first report of BZW1/5MP2 as an oncogene in 2009 indicates that 5MP1/2 proteins promote proliferation, metastasis and poor prognosis across diverse cancer types. However, the downstream effectors and mechanistic pathways linking translation control to tumorigenesis remain incompletely defined. This review summarizes current biochemical understanding of 5MP1 in translation initiation and synthesizes evidence supporting its tumor-promoting activities, outlining key questions and future directions.","PeriodicalId":15234,"journal":{"name":"Journal of biochemistry","volume":" ","pages":"309-316"},"PeriodicalIF":2.4,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146105606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of lipoylation in mitochondrial supercomplex formation during C2C12 cell differentiation. 脂酰化在C2C12细胞分化过程中线粒体超复合体形成中的作用。

IF 2.4 4区生物学

Journal of biochemistry Pub Date : 2026-05-11 DOI: 10.1093/jb/mvag014

Hijiri Oshio, Isshin Shiiba, Anju Takeda, Souichirou Matsumoto, Yuto Ishikawa, Shun Nagashima, Ryoko Inatome, Shigeru Yanagi

{"title":"Role of lipoylation in mitochondrial supercomplex formation during C2C12 cell differentiation.","authors":"Hijiri Oshio, Isshin Shiiba, Anju Takeda, Souichirou Matsumoto, Yuto Ishikawa, Shun Nagashima, Ryoko Inatome, Shigeru Yanagi","doi":"10.1093/jb/mvag014","DOIUrl":"10.1093/jb/mvag014","url":null,"abstract":"In mitochondria, the pyruvate dehydrogenase complex (PDHC) serves as a key metabolic regulatorGraphical Abstract by converting glycolysis-derived pyruvate into acetyl-CoA, thereby controlling carbon flux into the tricarboxylic acid cycle. PDHC activity is tightly regulated by two post-translational modifications: phosphorylation of the E1 subunit and lipoylation of the E2 subunit. While phosphorylation of E1 reversibly suppresses pyruvate dehydrogenase (PDH) activity, lipoylation of E2 is essential for intra-complex electron transfer reactions, and together these modifications define PDHC enzymatic activity. Mitochondrial respiratory supercomplexes (SCs) play a critical role in efficient electron transfer during mitochondrial respiration, and PDH has been reported to regulate SC organization. However, it remains unclear whether this regulatory mechanism, including subunit phosphorylation, is linked to protein lipoylation. In this study, we examined the impact of protein lipoylation on the phosphorylation status of the PDHC E1 subunit and on mitochondrial respiratory SC formation during C2C12 differentiation. To this end, suppression of lipoic acid synthase, a key enzyme responsible for mitochondrial protein lipoylation, in C2C12 cells resulted in dephosphorylation of the PDHC E1 subunit and formation of specific mitochondrial respiratory SCs. These findings suggest that PDHC E1 dephosphorylation and specific mitochondrial respiratory SC assembly can occur under conditions of impaired E2 lipoylation.","PeriodicalId":15234,"journal":{"name":"Journal of biochemistry","volume":" ","pages":"351-362"},"PeriodicalIF":2.4,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146258310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Whole-blood transcriptomics in a Japanese population cohort: physiological and methodological insights. 全血转录组学在日本人群队列：生理学和方法学的见解。

IF 2.4 4区生物学

Journal of biochemistry Pub Date : 2026-05-11 DOI: 10.1093/jb/mvaf083

Hiroaki Tachiwana

{"title":"Whole-blood transcriptomics in a Japanese population cohort: physiological and methodological insights.","authors":"Hiroaki Tachiwana","doi":"10.1093/jb/mvaf083","DOIUrl":"10.1093/jb/mvaf083","url":null,"abstract":"Whole blood transcriptomics promises a practical readout of human physiology. However, several key gaps have limited its utility. Systematic analyses in healthy participants within prospective cohorts remain scarce. In addition, there is uncertainty about how age and sex shape whole-blood expression profiles, and no methodological consensus exists on whether globin mRNAs should be removed before analysis. Against this backdrop, Aoki and colleagues conducted a large-scale study using whole-blood RNA sequencing (RNA-seq) from 576 participants in the Tohoku Medical Megabank Project, aiming to generate foundational data for the Japanese population. By retaining globin transcripts and then applying in silico removal, they detected rare hereditary persistence of foetal haemoglobin (HPFH) cases, showed that immune-cell composition-particularly the neutrophil-to-lymphocyte ratio-drives major variance, and uncovered extensive age- and sex-dependent signatures, including pregnancy-associated NRF2 activation. Together, these results move the field toward establishing a Japanese whole-blood gene-expression reference by providing standardized, stratified baseline profiles and practical guidance on globin handling. This commentary explains why these choices matter and how the dataset will inform population-aware blood transcriptomics.","PeriodicalId":15234,"journal":{"name":"Journal of biochemistry","volume":" ","pages":"305-307"},"PeriodicalIF":2.4,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145850176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DAXX promotes SUMOylation of chromatin-trapped DNMT1. DAXX促进染色质捕获的DNMT1的sumo化。

IF 2.4 4区生物学

Journal of biochemistry Pub Date : 2026-05-11 DOI: 10.1093/jb/mvag011

Shota Tanimoto, Teh-Wei Wang, Tomohiro Yabushita, Yoshie Chiba, Chieko Konishi, Akinori Endo, Yasushi Saeki, Susumu Goyama, Makoto Nakanishi, Atsuya Nishiyama

{"title":"DAXX promotes SUMOylation of chromatin-trapped DNMT1.","authors":"Shota Tanimoto, Teh-Wei Wang, Tomohiro Yabushita, Yoshie Chiba, Chieko Konishi, Akinori Endo, Yasushi Saeki, Susumu Goyama, Makoto Nakanishi, Atsuya Nishiyama","doi":"10.1093/jb/mvag011","DOIUrl":"10.1093/jb/mvag011","url":null,"abstract":"The cytosine analogue 5-aza-2'-deoxycytidine (decitabine; DAC) covalently inhibits DNA methyltransferase 1 (DNMT1), the maintenance DNA methyltransferase, and induces SUMOylation of DNA-trapped DNMT1, promoting proteasomal degradation. However, the regulation of DNMT1 SUMOylation and its biological impact remain unclear. Here, using interphase Xenopus egg extracts that reconstitute maintenance DNA methylation in vitro, we identify death domain-associated protein (DAXX) as a regulator of SUMOylation on chromatin-retained, inactive DNMT1. First, adding 5-aza-dCTP, the triphosphate form of decitabine, induced DNMT1 accumulation on chromatin and robust SUMO2/3 conjugation. Chromatin mass spectrometry (CHROMASS) revealed DAXX enrichment on 5-aza-dCTP-treated chromatin in a SUMO-dependent manner, and DAXX depletion suppressed 5-aza-dCTP-induced DNMT1 SUMOylation. Furthermore, GSK-3484862, a non-covalent DNMT1 inhibitor, drove DNMT1 accumulation on chromatin and triggered DAXX-dependent DNMT1 SUMOylation. We also demonstrated that DAXX loss increased decitabine sensitivity in the myeloid leukaemia (AML) cell line THP-1. Together, these findings show that DAXX promotes SUMOylation of DNMT1 trapped on DNA under both covalent and non-covalent trapping conditions.","PeriodicalId":15234,"journal":{"name":"Journal of biochemistry","volume":" ","pages":"363-373"},"PeriodicalIF":2.4,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146180042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0