Journal of Cardiovascular Translational Research最新文献_第5页

CRISPR-Cas9 Targeting PCSK9: A Promising Therapeutic Approach for Atherosclerosis. 靶向PCSK9的CRISPR-Cas9：一种有希望的动脉粥样硬化治疗方法

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-01-13 DOI: 10.1007/s12265-024-10587-7

Bin Gu, Min Li, Dan Li, Kaisen Huang

引用次数: 0

Development and Internal Validation of an AI-Enabled Cuff-less, Non-invasive Continuous Blood Pressure Monitor Across All Classes of Hypertension. 开发并在内部验证人工智能无袖带无创连续血压监测仪，适用于所有类型的高血压。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-01-13 DOI: 10.1007/s12265-024-10589-5

Francisco Lopez-Jimenez, Abhishek Deshmukh, John Bisognano, John Boehmer, Mouli Ramasamy, Prashanth Shyam Kumar, Suraj Kapa, Venk Varadan, Vijay Varadan, Marat Fudim

{"title":"Development and Internal Validation of an AI-Enabled Cuff-less, Non-invasive Continuous Blood Pressure Monitor Across All Classes of Hypertension.","authors":"Francisco Lopez-Jimenez, Abhishek Deshmukh, John Bisognano, John Boehmer, Mouli Ramasamy, Prashanth Shyam Kumar, Suraj Kapa, Venk Varadan, Vijay Varadan, Marat Fudim","doi":"10.1007/s12265-024-10589-5","DOIUrl":"https://doi.org/10.1007/s12265-024-10589-5","url":null,"abstract":"Background: Non-invasive, continuous blood pressure monitoring technologies require additional validation beyond standard cuff-based methods. This study evaluates a non-invasive, multiparametric wearable cuffless blood pressure (BP) diagnostic monitor across all hypertension classes with diverse subjects.Methods: A prospective, multicenter study assessed Nanowear's SimpleSense-BP performance, including induced and natural BP changes, significant BP variations (Systolic BP (SBP) ≥ ± 15 mm Hg and Diastolic BP (DBP) ≥ ± 10 mm Hg), and reference input value validity over 4 weeks.Results: 303 subjects (18-83 yrs; 50.16% Female) participated in algorithmic development and validation (Normal - 35%, Prehypertensive - 24%, Stage 1 - 24%, Stage 2 - 17%). 54 subjects were tested for induced change performance, 149 exhibited significant changes, and 91 validated reference value duration.Conclusions: The study clinically validated a continuous, AI-based BP diagnostic monitor using non-invasive wearable data. Further testing on diverse populations and external validation are recommended. The protocol was inspired by ISO 81060-2 and IEEE 1708:2019 standards.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long Non-Coding RNAs in Diabetic Cardiomyopathy: Potential Function as Biomarkers and Therapeutic Targets of Exercise Training. 长链非编码rna在糖尿病性心肌病中的潜在功能：作为生物标志物和运动训练的治疗靶点。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-01-09 DOI: 10.1007/s12265-024-10586-8

Jie Hu, Xinwen Miao, Li-Hua Yu

{"title":"Long Non-Coding RNAs in Diabetic Cardiomyopathy: Potential Function as Biomarkers and Therapeutic Targets of Exercise Training.","authors":"Jie Hu, Xinwen Miao, Li-Hua Yu","doi":"10.1007/s12265-024-10586-8","DOIUrl":"https://doi.org/10.1007/s12265-024-10586-8","url":null,"abstract":"Recent studies emphasize the beneficial effects of exercise on diabetic cardiomyopathy (DCM), adding to the growing body of evidence that underscores the role of exercise in improving health outcomes. Despite this, a notable gap persists in the number of healthcare providers who actively prescribe exercise as a therapeutic intervention for DCM management. In addition, exercise modulates the expression of lncRNAs, which play a pivotal role in DCM progression. Further investigation into this relationship may facilitate the identification of novel biomarkers and therapeutic targets for DCM. This review consolidates recent advances in identifying lncRNAs biomarkers in DCM, summarizing the current knowledge on dysregulated lncRNAs and their molecular mechanisms. Additionally, it offers new insights into the mechanistic roles of lncRNAs, highlighting their potential as biomarkers and therapeutic targets for DCM. Overall, this review aims to inform future research and reinforce the significance of addressing diabetes-related cardiovascular diseases to potentially improve clinical outcomes.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-01-09 DOI: 10.1007/s12265-024-10583-x

Xing-Jie Wang, Lei Huang, Min Hou, Jie Guo

{"title":"Senescence-related Genes as Prognostic Markers for STEMI Patients: LASSO Regression-Based Bioinformatics and External Validation.","authors":"Xing-Jie Wang, Lei Huang, Min Hou, Jie Guo","doi":"10.1007/s12265-024-10583-x","DOIUrl":"https://doi.org/10.1007/s12265-024-10583-x","url":null,"abstract":"The prognostic value of differentially expressed senescence-related genes(DESRGs) in ST-segment elevation myocardial infarction(STEMI) patients is unclear. We used GEO2R to identify DESRGs from GSE60993 and performed functional enrichment analysis. We built an optimal prognostic model with LASSO penalized Cox regression via GSE49925. We evaluated the model with survival analysis, ROC curve, decision curve analysis, nomogram, and external validation with plasma samples. We created a prognostic signature with three dysregulated DESRGs (CDC25B, FKBP5, and ECHDC3) and two clinical variables (serum creatinine, Gensini score). The signature stratified patients into low- and high-risk groups and showed strong predictive performance within two years. The external validation confirmed the survival difference between the groups. We identified three DESRGs that were differentially expressed and prognostic in STEMI patients. The model incorporating three DESRGs showed promising prediction and utility for stratifying patients and estimating survival risk in STEMI patients.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic Value and Short-Term Prognosis Assessment of Copeptin in Non-ST-Elevation Acute Coronary Syndrome. Copeptin在非st段抬高急性冠脉综合征中的诊断价值及短期预后评价。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-12-28 DOI: 10.1007/s12265-024-10584-w

Facai Cui, Xueliang Pei, Mingzhi Ling, Fengxia Guo

引用次数: 0

Bufalin Ameliorates Myocardial Ischemia/Reperfusion Injury by Suppressing Macrophage Pyroptosis via P62 Pathway. 蟾毒灵通过P62途径抑制巨噬细胞焦亡改善心肌缺血再灌注损伤

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-12-28 DOI: 10.1007/s12265-024-10577-9

Chang Li, Zhen Ma, Xiang Wei, Ying Wang, Jian Wu, Xuan Li, Xiaolei Sun, Zhiwen Ding, Cheng Yang, Yunzeng Zou

{"title":"Bufalin Ameliorates Myocardial Ischemia/Reperfusion Injury by Suppressing Macrophage Pyroptosis via P62 Pathway.","authors":"Chang Li, Zhen Ma, Xiang Wei, Ying Wang, Jian Wu, Xuan Li, Xiaolei Sun, Zhiwen Ding, Cheng Yang, Yunzeng Zou","doi":"10.1007/s12265-024-10577-9","DOIUrl":"https://doi.org/10.1007/s12265-024-10577-9","url":null,"abstract":"Bufalin, which is isolated from toad venom, exerts positive effects on hearts under pathological circumstance. We aimed to investigate the effects and mechanisms of bufalin on myocardial I/R injury. In vivo, bufalin ameliorated myocardial I/R injury, which characteristics with better ejection function, decreased infarct size and less apoptosis. The levels of pyroptotic proteins were increased in I/R-treated macrophages and inflammatory cytokines expressed more in I/R-induced mouse, which could be attenuated by bufalin. Bufalin also reduced H/R-treated macrophage pyroptosis in vitro. Autophagic flux blockage and ROS accumulation were reduced by bufalin in impaired macrophages. Overexpression of p62 abrogated the anti-proptosis and anti-oxidative effects of bufalin. The levels of apoptosis related proteins were changed and TUNEL-positive ratio was raised in cardiomyocytes that received conditioned medium treatment with H/R-treated macrophages, while bufalin pretreatment could reduce apoptosis. These findings indicate that bufalin may attenuate myocardial I/R injury by suppressing macrophage pyroptosis via P62 pathway.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: AIM2 Deficiency Alleviates Cardiac Inflammation and Hypertrophy in HFD/STZ-Induced Diabetic Mice by Inhibiting the NLRC4/IRF1 Signaling Pathway. 更正：AIM2缺乏通过抑制NLRC4/IRF1信号通路减轻HFD/ stz诱导的糖尿病小鼠心脏炎症和肥厚。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-12-26 DOI: 10.1007/s12265-024-10582-y

Jian-Ping Wu, Cheng Wu, Yuan-Ji Ma, Jian-Bing Zhu, Lei-Lei Ma, Fei-Juan Kong

引用次数: 0

Machine Learning Model for Risk Prediction of Prolonged Intensive Care Unit in Patients Receiving Intra-aortic Balloon Pump Therapy during Coronary Artery Bypass Graft Surgery. 机器学习模型在冠状动脉搭桥术中接受主动脉内球囊泵治疗的患者延长重症监护病房的风险预测。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-12-24 DOI: 10.1007/s12265-024-10580-0

Changqing Yang, Peng Zheng, Qian Zhang, Luo Li, Yajun Zhang, Quanye Li, Sheng Zhao, Zhan Shi

{"title":"Machine Learning Model for Risk Prediction of Prolonged Intensive Care Unit in Patients Receiving Intra-aortic Balloon Pump Therapy during Coronary Artery Bypass Graft Surgery.","authors":"Changqing Yang, Peng Zheng, Qian Zhang, Luo Li, Yajun Zhang, Quanye Li, Sheng Zhao, Zhan Shi","doi":"10.1007/s12265-024-10580-0","DOIUrl":"https://doi.org/10.1007/s12265-024-10580-0","url":null,"abstract":"This study aimed to construct machine learning models and predict prolonged intensive care units (ICU) stay in patients receiving perioperative intra-aortic balloon pump (IABP) therapy during cardiac surgery. 236 patients were divided into the normal (≤ 14 days) and prolonged (> 14 days) ICU groups based on the 75th percentile of ICU duration across the entire cohort. Seven machine learning models were trained and validated. The Shapley Additive explanations (SHAP) method was employed to illustrate the effects of the features. 94 patients (39.83%) experienced prolonged ICU stay. The XGBoost model outperformed other models in predictive performance, as evidenced by its highest area under the receiver operating characteristic curve (training: 0.92; validation: 0.73). The SHAP analysis identified tracheotomy, albumin, Sv1, and cardiac troponin T as the top four risk variables. The XGBoost model predicted risk variables for prolonged ICU stay in patients, possibly contributing to improving perioperative management and reducing ICU duration.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NAT10 Modulates Atherosclerosis Progression Mediated by Macrophage Polarization Through Regulating ac4C Modification of TLR9. NAT10通过调节TLR9的ac4C修饰调节巨噬细胞极化介导的动脉粥样硬化进程。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-12-19 DOI: 10.1007/s12265-024-10579-7

Wei Yin, Jie Wang, Lingling Li, Hongyun Zheng, Shengkai Xu

{"title":"NAT10 Modulates Atherosclerosis Progression Mediated by Macrophage Polarization Through Regulating ac4C Modification of TLR9.","authors":"Wei Yin, Jie Wang, Lingling Li, Hongyun Zheng, Shengkai Xu","doi":"10.1007/s12265-024-10579-7","DOIUrl":"https://doi.org/10.1007/s12265-024-10579-7","url":null,"abstract":"Atherosclerosis (AS) is an inflammatory disease affected by macrophage polarization. N4-acetylcytosine (ac4C) modification mediated by N-acetyltransferase 10 (NAT10). In this study, we aimed to elucidate the role of ac4C modification mediated macrophage polarization in AS through in vivo and in vitro experiments. The ac4C level was measured using dot blot. Macrophage polarization was assessed by quantitative real-time PCR and flow cytometry. Underlying mechanism was analyzed by methylated RNA Immunoprecipitation (MeRIP), RIP and dual luciferase report. Results showed that the NAT10 expression and ac4C level were increased in patients with AS. Additionally, NAT10 knockdown promoted M1 to M2 polarization and suppressed TLR9 ac4C level. TLR9 overexpression reversed macrophage polarization regulated by NAT10 knockdown. Furthermore, M1 polarization and atherosclerosis in vivo was inhibited by NAT10 knockdown. In conclusion, we demonstrated that NAT10 regualted AS progression mediated by macrophage polarization through regulating ac4C modification of TLR9 and provided a new theoretical basis.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations of Blood Lipid-Related Polygenic Scores, Lifestyle Factors and Their Combined Effects with Risk of Coronary Artery Disease in the UK Biobank Cohort. 英国生物库队列中血脂相关多基因评分、生活方式因素及其综合效应与冠状动脉疾病风险的关系。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-12-16 DOI: 10.1007/s12265-024-10578-8

Jungyoon Choi, Wanqing Wen, Guochong Jia, Ran Tao, Jirong Long, Xiao-Ou Shu, Wei Zheng

引用次数: 0