Journal of Cardiovascular Translational Research最新文献_第10页

Clinical Impact of the Endo-aortic Clamp for Redo Mitral Valve Surgery 重做二尖瓣手术中主动脉内夹钳的临床影响

IF 3.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-04-17 DOI: 10.1007/s12265-024-10509-7

Cristina Barbero, Andrea Costamagna, Peter Verbrugghe, Joseph Zacharias, Frank Van Praet, Thierry Bove, Alfonso Agnino, Jörg Kempfert, Mauro Rinaldi

{"title":"Clinical Impact of the Endo-aortic Clamp for Redo Mitral Valve Surgery","authors":"Cristina Barbero, Andrea Costamagna, Peter Verbrugghe, Joseph Zacharias, Frank Van Praet, Thierry Bove, Alfonso Agnino, Jörg Kempfert, Mauro Rinaldi","doi":"10.1007/s12265-024-10509-7","DOIUrl":"https://doi.org/10.1007/s12265-024-10509-7","url":null,"abstract":"<p>Aim of this study was to compare redo MV surgery patients undergoing right mini-thoracotomy and EAC with redo MV patients undergoing surgery through other approaches. Redo MV patients from 7 European centers were analyzed. Primary endpoint was 30-day mortality; secondary endpoints were stroke, re-exploration, low cardiac output syndrome (LCOS), respiratory failure, and intensive care unit (ICU) and in-hospital length-of-stay. Forty-nine patients underwent right mini-thoracotomy and EAC (22.7%), and 167 (77.3%) underwent surgery through other approaches (112 sternotomy, 40 unclamped mini-thoracotomies, and 15 mini-thoracotomies with trans-thoracic clamp). Thirty-day mortality, stroke, re-exploration for bleeding, and weaning failure were comparable. The EAC group showed significant lower rate of LCOS (<i>p</i> = 0.03) and shorter ICU (<i>p</i> = 0.04) and in-hospital length of stay (<i>p</i> = 0.002). The EAC allows the surgeon to reach the aorta, to clamp it, and to deliver the cardioplegia with a “no-touch” technique, with significant improvement in outcomes.</p><h3 data-test=\"abstract-sub-heading\">Graphical Abstract</h3>\u0000","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140611296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ventricular Epicardial Adipose Distribution on Human Hearts: 3-Dimensional Reconstructions and Quantitative Assessments 人心室心外膜脂肪分布：三维重建和定量评估

IF 3.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-04-16 DOI: 10.1007/s12265-024-10505-x

Renee C. Brigham, Alexander R. Mattson, Paul A. Iaizzo

{"title":"Ventricular Epicardial Adipose Distribution on Human Hearts: 3-Dimensional Reconstructions and Quantitative Assessments","authors":"Renee C. Brigham, Alexander R. Mattson, Paul A. Iaizzo","doi":"10.1007/s12265-024-10505-x","DOIUrl":"https://doi.org/10.1007/s12265-024-10505-x","url":null,"abstract":"<p>Epicardial interventions have forged new frontiers in cardiac ablation and device therapies. Healthy human hearts typically present with significant adipose tissue layers superficial to the ventricular myocardium and may hinder success or increase the complexities of epicardial interventions. We quantitatively evaluated the distribution of epicardial adipose tissue on the surface of human hearts and provided high-fidelity 3-dimensional reconstructions of these epicardial adipose tissue layers. The regional thickness of adipose tissues was analyzed at 51 anatomical reference points surrounding both ventricles and compared to specific patient demographics. Adipose deposits on the human hearts displayed characteristic patterns, with the thickest accumulations along the interventricular septa (anterior, 9.01 ± 0.50 mm; posterior, 6.78 ± 0.50 mm) and the right ventricular margin (7.44 ± 0.57 mm). We provide one of the most complete characterizations of human epicardial adipose location and relative layer thickness. These results are considered fundamental for an underlying anatomic understanding when performing procedures within the pericardial space.</p><h3 data-test=\"abstract-sub-heading\">Graphical Abstract</h3><p>The relative thickness of epicardial adipose tissue was analyzed across 80 human hearts, with a subset displayed here as 3D reconstructions with thinner to thicker adipose regions indicated by a relative green-to-red color scale.</p>\u0000","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140567965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: TJ-M2010-5 Attenuates Severe Myocardial Ischemia/Reperfusion Injury in Heart Transplantation by Inhibiting MyD88 Homodimerization In Vivo. 更正：TJ-M2010-5通过抑制体内MyD88同源二聚化减轻心脏移植中严重的心肌缺血/再灌注损伤

IF 3.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-04-16 DOI: 10.1007/s12265-024-10507-9

Huifang Yang, Ping Zhou, Qingwen Li, Xi Zhou, Junbo Li, Jin Wang, Jingzeng Wang, Yuanyuan Zhao, Bo Yang, Bo Zhang, Chen Dai, Zhimiao Zou, Yang Yang, Zhishui Chen

引用次数: 0

Eosinophil Recovery Time Is Associated with Clinical Outcomes in Patients with Type A Acute Aortic Dissection: a Retrospective Cohort Study 嗜酸性粒细胞恢复时间与 A 型急性主动脉夹层患者的临床结局有关：一项回顾性队列研究

IF 3.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-04-15 DOI: 10.1007/s12265-023-10468-5

Xue Wang, Yanli Zhu, Xiaojuan Ma, Jun Ren, Yang Yan, Yanqing Liu, Heng Gao, Shaofei Zhang, Ying Chen, Yang Yang, Chao Deng

{"title":"Eosinophil Recovery Time Is Associated with Clinical Outcomes in Patients with Type A Acute Aortic Dissection: a Retrospective Cohort Study","authors":"Xue Wang, Yanli Zhu, Xiaojuan Ma, Jun Ren, Yang Yan, Yanqing Liu, Heng Gao, Shaofei Zhang, Ying Chen, Yang Yang, Chao Deng","doi":"10.1007/s12265-023-10468-5","DOIUrl":"https://doi.org/10.1007/s12265-023-10468-5","url":null,"abstract":"<p>Type A acute aortic dissection (TA-AAD) patients are prone to life-threatening complications and death. This study aimed to analyze the association between eosinophil (EOS) recovery and clinical outcomes in TA-AAD. A total of 274 patients with TA-AAD were eligible for inclusion, and 54 patients died within 1 month. The patients with poor clinical outcomes showed significantly lower EOS count within 8 days after surgery. The time-dependent ROC analysis showed that EOS recovery days predicted 1-month death with an AUC of 0.886 and a cutoff of 6 days. EOS recovery within 6 days was associated with a lower incidence of postoperative infection, a poorer prognosis, and a lower risk of 1-month and 6-month mortality than those requiring more recovery days. Collectively, postoperative early recovery of EOS predicted lower mortality and better prognosis and may be applied as an effective, rapid, and simple tool for the risk stratification and prognostic prediction of patients with TA-AAD.</p><p><b>Clinical trial registration number:</b> NCT05409677.</p><h3 data-test=\"abstract-sub-heading\">Graphical Abstract</h3>\u0000","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140567930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mild Therapeutic Hypothermia Alleviated Myocardial Ischemia/Reperfusion Injury via Targeting SLC25A10 to Suppress Mitochondrial Apoptosis 轻度治疗性低温通过靶向 SLC25A10 抑制线粒体凋亡减轻心肌缺血再灌注损伤

IF 3.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-04-03 DOI: 10.1007/s12265-024-10503-z

Senlin Ma, Yun Song, Yanxin Xu, Chao Wang, Yifan Yang, Yanchao Zheng, Qiuxin Lu, Qingjiang Chen, Jian Wu, Bin Wang, Mingquan Chen

{"title":"Mild Therapeutic Hypothermia Alleviated Myocardial Ischemia/Reperfusion Injury via Targeting SLC25A10 to Suppress Mitochondrial Apoptosis","authors":"Senlin Ma, Yun Song, Yanxin Xu, Chao Wang, Yifan Yang, Yanchao Zheng, Qiuxin Lu, Qingjiang Chen, Jian Wu, Bin Wang, Mingquan Chen","doi":"10.1007/s12265-024-10503-z","DOIUrl":"https://doi.org/10.1007/s12265-024-10503-z","url":null,"abstract":"<p>Myocardial ischemia/reperfusion injury (MI/RI) is identified as a severe vascular emergency, and the treatment strategy of MI/RI still needs further improvement. The present study aimed to investigate the potential effects of mild therapeutic hypothermia (MTH) on MI/RI and underlying mechanisms. In ischemia/reperfusion (I/R) rats, MTH treatment significantly improved myocardial injury, attenuated myocardial infarction, and inhibited the mitochondrial apoptosis pathway. The results of proteomics identified SLC25A10 as the main target of MTH treatment. Consistently, SLC25A10 expressions in I/R rat myocardium and hypoxia and reoxygenation (H/R) cardiomyocytes were significantly suppressed, which was effectively reversed by MTH treatment. In H/R cardiomyocytes, MTH treatment significantly improved cell injury, mitochondrial dysfunction, and inhibited the mitochondrial apoptosis pathway, which were partially reversed by SLC25A10 deletion. These findings suggested that MTH treatment could protect against MI/RI by modulating SLC25A10 expression to suppress mitochondrial apoptosis pathway, providing new theoretical basis for clinical application of MTH treatment for MI/RI.</p><h3 data-test=\"abstract-sub-heading\">Graphical Abstract</h3>\u0000","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140567926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Progress on Histone Deacetylases Regulating Programmed Cell Death in Atherosclerosis. 组蛋白脱乙酰酶调控动脉粥样硬化细胞程序性死亡的研究进展。

IF 3.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-04-01 Epub Date: 2023-10-11 DOI: 10.1007/s12265-023-10444-z

Gang Zhou, Yanfang Liu, Hui Wu, Dong Zhang, Qingzhuo Yang, Yi Li

引用次数: 0

Ascending Aorta 4D Time to Peak Distention Sexual Dimorphism and Association with Coronary Plaque Burden Severity in Women. 女性升主动脉 4D 达峰值扩张时间的性别二态性及其与冠状动脉斑块负担严重程度的关系。

IF 3.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-04-01 Epub Date: 2023-08-09 DOI: 10.1007/s12265-023-10422-5

Ahmed H Hamimi, Ahmed M Ghanem, Fady Hannah-Shmouni, Reham M Elgarf, Jatin R Matta, Ahmed M Gharib, Khaled Z Abd-Elmoniem

{"title":"Ascending Aorta 4D Time to Peak Distention Sexual Dimorphism and Association with Coronary Plaque Burden Severity in Women.","authors":"Ahmed H Hamimi, Ahmed M Ghanem, Fady Hannah-Shmouni, Reham M Elgarf, Jatin R Matta, Ahmed M Gharib, Khaled Z Abd-Elmoniem","doi":"10.1007/s12265-023-10422-5","DOIUrl":"10.1007/s12265-023-10422-5","url":null,"abstract":"<p><p>Coronary artery disease (CAD) risk and plaque scores are often subjective and biased, particularly in mid-age asymptomatic women, whose CAD risk assessment has been historically underestimated. In this study, a new automatic ascending aorta time-to-peak-distention (TPD) analysis was developed for fast screening and as an independent surrogate for subclinical atherosclerosis in asymptomatic women. CCTA was obtained in 50 asymptomatic adults. Plaque burden segment involvement score (SIS) and automatic TPD were obtained from all subjects. Logistic regression analyses were performed to investigate the association between CAD risk scores and TPD with severe coronary plaque burden (SIS>5). TPD, individually, was found to be a significant predictor of SIS>5. Additionally, sex was a significant effect modifier of TPD, with a stronger statistically significant association with women. Four-dimensional aortic time-to-peak distention could supplement conventional CCTA analysis and offer a quick objective screening tool for plaque burden severity and CAD risk stratification, especially in women.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9951580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postoperative Dipping Patterns of Mean Arterial Pressure and Mortality After Coronary Artery Bypass Grafting. 冠状动脉旁路移植术后平均动脉压下降模式与死亡率。

IF 3.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-04-01 Epub Date: 2024-01-09 DOI: 10.1007/s12265-023-10475-6

Bohao Jian, Haoliang Liu, Yi Zhang, Gang Li, Song Yang, Guangguo Fu, Suiqing Huang, Yang Huang, Zhuoming Zhou, Zhongkai Wu, Mengya Liang

{"title":"Postoperative Dipping Patterns of Mean Arterial Pressure and Mortality After Coronary Artery Bypass Grafting.","authors":"Bohao Jian, Haoliang Liu, Yi Zhang, Gang Li, Song Yang, Guangguo Fu, Suiqing Huang, Yang Huang, Zhuoming Zhou, Zhongkai Wu, Mengya Liang","doi":"10.1007/s12265-023-10475-6","DOIUrl":"10.1007/s12265-023-10475-6","url":null,"abstract":"<p><p>Blood pressure dipping patterns have long been considered to be associated with adverse events. We aimed to investigate whether dipping patterns of postoperative MAP were related to 90-day and hospital mortality in patients undergoing CABG. Four thousand three hundred ninety-one patients were classified into extreme dippers (night-to-day ratio of MAP ≤ 0.8), dippers (0.8 < night-to-day ratio of MAP ≤ 0.9), non-dippers (0.9 < night-to-day ratio of MAP ≤ 1), and reverse dippers (> 1). Compared with non-dippers, reverse dippers were at a higher risk of 90-day mortality (aHR = 1.58; 95% CI, 1.10-2.27) and hospital mortality (aOR = 1.97; 95% CI, 1.12-3.47). A significant interaction was observed between hypertension and dipping patterns (P for interaction = 0.02), with a significant increased risk of 90-day mortality in non-hypertensive reverse dippers (aHR = 1.90; 95% CI, 1.17-3.07) but not in hypertensive reverse dippers (aHR = 1.26; 95% CI, 0.73-2.19).</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139402989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the Molecular Mechanisms of Activated Protein C (APC) in Mitigating Reperfusion Injury and Cardiac Ischemia: a Promising Avenue for Novel Therapeutic Interventions. 揭示活化蛋白C（APC）在减轻再灌注损伤和心脏缺血中的分子机制：新的治疗干预措施的前景。

IF 3.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-04-01 Epub Date: 2023-10-18 DOI: 10.1007/s12265-023-10445-y

Nishant Johri, Prithpal S Matreja, Shalabh Agarwal, Priya Nagar, Deepanshu Kumar, Aditya Maurya

{"title":"Unraveling the Molecular Mechanisms of Activated Protein C (APC) in Mitigating Reperfusion Injury and Cardiac Ischemia: a Promising Avenue for Novel Therapeutic Interventions.","authors":"Nishant Johri, Prithpal S Matreja, Shalabh Agarwal, Priya Nagar, Deepanshu Kumar, Aditya Maurya","doi":"10.1007/s12265-023-10445-y","DOIUrl":"10.1007/s12265-023-10445-y","url":null,"abstract":"<p><p>Ischemic heart disease, which results from plaque formation in the coronary arteries, hinders the flow of oxygenated blood to the heart, leading to ischemia. Reperfusion injury remains a significant challenge for researchers, and the mechanisms underlying myocardial ischemia-reperfusion injury (MIRI) are not entirely understood. The review directs future research into potential targets in clinical treatment based on our present understanding of the pathophysiological mechanisms of MIRI. The study provides insights into the mechanisms underlying MIRI and offers direction for future research in this area. The use of targeted therapies may hold promise in improving cardiac function in the elderly and minimizing the adverse effects of revascularization therapies. The purpose of this review is to analyze the role of activated protein C (APC) in the pathogenesis of ischemic heart disease, heart failure, and myocardial ischemia-reperfusion injury, and discuss the potential of APC-based therapeutics.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41235642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epicardial Adipose Tissue: a Potential Therapeutic Target for Cardiovascular Diseases. 心外膜脂肪组织：心血管疾病的潜在治疗靶点。

IF 3.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-04-01 Epub Date: 2023-10-17 DOI: 10.1007/s12265-023-10442-1

Wenxi Fang, Saiyang Xie, Wei Deng

引用次数: 0