Journal of Cardiovascular Translational Research最新文献

Platelet microRNA Expression Can Predict Bleeding in HeartMate3 Patients Treated With or Without Aspirin. 血小板microRNA表达可预测服用或不服用阿司匹林的心绞痛患者出血。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-07-11 DOI: 10.1007/s12265-025-10659-2

Chiara Foglieni, Davide Ravanelli, Maria Lombardi, Lucia Spartano, Marina Pieri, Silvia Ajello, Giovanni Landoni, Anna Mara Scandroglio, Filippo Consolo

{"title":"Platelet microRNA Expression Can Predict Bleeding in HeartMate3 Patients Treated With or Without Aspirin.","authors":"Chiara Foglieni, Davide Ravanelli, Maria Lombardi, Lucia Spartano, Marina Pieri, Silvia Ajello, Giovanni Landoni, Anna Mara Scandroglio, Filippo Consolo","doi":"10.1007/s12265-025-10659-2","DOIUrl":"https://doi.org/10.1007/s12265-025-10659-2","url":null,"abstract":"We tested whether platelet microRNAs (miRs) expression can predict bleeding in patients supported with the HeartMate3 (HM3) left ventricular assist device (LVAD). The levels of expression of platelet miR-126, miR-233, miR-151a, and miR-454 were prospectively measured in 12 consecutive patients pre-implant and during long-term follow-up and compared based on aspirin (ASA) or ASA-free therapy at discharge and bleeding events over the course of HM3 support. Median time of follow-up was 760 (574-844) days. Seven (58%) patients were discharged on ASA and 5 (42%) without ASA. Three (25%) patients experienced 10 bleeding episodes: one never received ASA, and two suffered from bleeding recurrency long after permanent ASA discontinuation. ASA had minimal influence on platelet miRs expression. The expression levels of platelet miR-454 were lower in bleeders vs. non-bleeders, both pre-implant and post-implant. This study suggests the existence of a patient-specific pro-hemorrhagic phenotype associated with a distinctive expression profile of platelet miR-454. Clinical Trial Registration: https://clinicaltrials.gov/ct2/show/NCT03255928 . ClinicalTrials.gov Identifier: NCT03255928.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Proteome Profile of Stress Test Assessed Cardiovascular Disease Risk-Prone Diabetic Subjects. 应激测试评估心血管疾病风险易感性糖尿病受试者的蛋白质组谱

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-07-10 DOI: 10.1007/s12265-025-10651-w

Yugendra R Patil, Shalbha Tiwari, A G Unnikrishnan, Mahesh J Kulkarni

引用次数: 0

Circulating miRNAs Signature as a Predictor of Cachexia in Chronic Heart Failure: Diagnostic and Prognostic Implications. 循环mirna信号作为慢性心力衰竭恶病质的预测因子：诊断和预后意义。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-07-10 DOI: 10.1007/s12265-025-10658-3

Tomasz Powrózek, Marcin Mazurek, Aneta Skwarek-Dziekanowska, Grzegorz Sobieszek, Debora Maffeo, Elisa Frullanti, Teresa Małecka-Massalska

{"title":"Circulating miRNAs Signature as a Predictor of Cachexia in Chronic Heart Failure: Diagnostic and Prognostic Implications.","authors":"Tomasz Powrózek, Marcin Mazurek, Aneta Skwarek-Dziekanowska, Grzegorz Sobieszek, Debora Maffeo, Elisa Frullanti, Teresa Małecka-Massalska","doi":"10.1007/s12265-025-10658-3","DOIUrl":"https://doi.org/10.1007/s12265-025-10658-3","url":null,"abstract":"Cachexia, often seen in chronic heart failure (CHF), worsens patient outcomes and survival. Early detection is crucial, and circulating miRNAs offer potential as biomarkers linking heart function, inflammation, and cachexia. This study aimed to identify plasma miRNAs associated with cachexia in CHF and assess their diagnostic and prognostic value. Plasma samples from 150 newly diagnosed CHF patients were analyzed using next-generation sequencing (NGS) and validated by qRT-PCR. A signature of elevated miRNA-628 and reduced miRNA-6803 (↑miRNA-628+↓miRNA-6803) was associated with poor nutritional status, abnormal lab results, and higher cachexia risk. Combining this signature with inflammatory markers perfectly distinguished cachectic from non-cachectic patients (AUC=1.0). This profile increased cachexia risk 19-fold and was linked to significantly shorter survival (median 14 vs. 41 months). Thus, the identified miRNA signature offers strong predictive and diagnostic potential and could complement clinical assessments of CHF patients' nutritional status.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Molecular Perspective on the Intricate Interplay Among Exosomes, Bioenergetic Metabolism, and the Pathogenesis of Diabetic Cardiomyopathy. 外泌体、生物能量代谢和糖尿病性心肌病发病机制之间复杂相互作用的分子视角。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-07-07 DOI: 10.1007/s12265-025-10655-6

Kaviyarasi Renu

{"title":"A Molecular Perspective on the Intricate Interplay Among Exosomes, Bioenergetic Metabolism, and the Pathogenesis of Diabetic Cardiomyopathy.","authors":"Kaviyarasi Renu","doi":"10.1007/s12265-025-10655-6","DOIUrl":"https://doi.org/10.1007/s12265-025-10655-6","url":null,"abstract":"Diabetic cardiomyopathy (DCM), defined as cardiac impairment resulting from the development of diabetes mellitus, has emerged as a global epidemic. DCM primarily denotes myocardial metabolic impairment induced by elevated glucose levels, with hyperglycemia serving as a separate risk factor for heart disease in a lack of hypertension and coronary atherosclerosis. Exosomes, a category of tiny extracellular vesicles essential for communication between cells, have attracted considerable interest for their prospective use in the investigation and management of DCM. Exosomes harbour bioactive chemicals that indicate specific physiological conditions, modulate bioenergetic metabolism, and facilitate tissue healing. This review elucidates the dynamic progression of exosome research in DCM through bioenergetic disruptions, encompassing different processes such as endothelial dysfunction, mitochondrial impairment, calcium signalling in the endoplasmic reticulum, cell death including apoptosis and ferroptosis, inflammation-related fibrosis, autophagy, and hypertrophy. It emphasizes the necessity for continued research to fully exploit the potential of exosomes in enhancing patient outcomes.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Insights Into Targeting Interleukin-27 in Coronary Artery Disease. 靶向白介素-27治疗冠状动脉疾病的新进展

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-07-07 DOI: 10.1007/s12265-025-10656-5

Wei-Lin Liang, Liang Liu, Bo Liang

引用次数: 0

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-07-07 DOI: 10.1007/s12265-025-10653-8

Xiufang Jiang, Yanling Lei, Yajuan Yin, Fangfang Ma, Gang Liu, Mingqi Zheng

引用次数: 0

Identification of Prognostic Factors for Sepsis or Septic Shock Patients with Cardiac Dysfunction. 脓毒症或感染性休克合并心功能障碍患者预后因素的鉴定。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-07-05 DOI: 10.1007/s12265-025-10645-8

Jinsheng Tian, Yan Liu, Yutong Zhao, Zengrong Wang, Lili Wang

引用次数: 0

Acetyl-CoA Short-Chain Synthetase-2 Regulates Myocardial Ischemia/Reperfusion Injury by Targeting Histone Acetylation. 乙酰辅酶a短链合成酶-2通过靶向组蛋白乙酰化调控心肌缺血/再灌注损伤

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-07-01 DOI: 10.1007/s12265-025-10657-4

Xinhui Chen, Qingling Xu, Wei Ding, Yu Wang, Puhan Wang, Chunyige Zhao, Xiang Ao, Jianxun Wang

引用次数: 0

Intracoronary Stenting and Restenosis - Randomized Trial of Drug-Eluting Stent Implantation or Drug-Coated Balloon Angioplasty According to Neointima Morphology in Drug-Eluting Stent REstenosis 5: Rationale and Design of the ISAR-DESIRE 5 Trial. 冠状动脉内支架植入和再狭窄-根据药物洗脱支架再狭窄新生内膜形态选择药物洗脱支架植入或药物包被球囊成形术的随机试验5:ISAR-DESIRE 5试验的基本原理和设计

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-30 DOI: 10.1007/s12265-025-10650-x

Fiorenzo Simonetti, Felix Voll, Fernando Alfonso, Christian Gräßer, Marion Janisch, Michael Joner, Thorsten Kessler, Constantin Kuna, David Manuel Leistner, Tobias Lenz, Antonia Presch, Tobias Rheude, Hendrik Sager, Heribert Schunkert, Fabian Starnecker, Jens Wiebe, Adnan Kastrati, Salvatore Cassese, Erion Xhepa

{"title":"Intracoronary Stenting and Restenosis - Randomized Trial of Drug-Eluting Stent Implantation or Drug-Coated Balloon Angioplasty According to Neointima Morphology in Drug-Eluting Stent REstenosis 5: Rationale and Design of the ISAR-DESIRE 5 Trial.","authors":"Fiorenzo Simonetti, Felix Voll, Fernando Alfonso, Christian Gräßer, Marion Janisch, Michael Joner, Thorsten Kessler, Constantin Kuna, David Manuel Leistner, Tobias Lenz, Antonia Presch, Tobias Rheude, Hendrik Sager, Heribert Schunkert, Fabian Starnecker, Jens Wiebe, Adnan Kastrati, Salvatore Cassese, Erion Xhepa","doi":"10.1007/s12265-025-10650-x","DOIUrl":"https://doi.org/10.1007/s12265-025-10650-x","url":null,"abstract":"In-stent restenosis (ISR) is the leading cause of revascularization failure, occurring in up to 10% of patients within 10 years after drug-eluting stent (DES) implantation, and is associated with increased mortality and rehospitalization. Guideline-writing authorities recommend DES over drug-coated balloons (DCB) for ISR treatment. However, this indication is mainly based on trials that did not incorporate intravascular imaging. Recent findings suggest that optical coherence tomography (OCT) patterns in ISR may influence treatment outcomes. The ISAR-DESIRE 5 trial is a randomized study to evaluate whether OCT-defined ISR tissue morphology affects treatment with DES versus DCB. 376 patients with ISR will be stratified by OCT pattern (homogeneous vs. non-homogeneous) and randomized 1:1 to DES or DCB. The trial is powered to detect an interaction between OCT pattern and treatment modality on the 24-month incidence of major adverse cardiac events and represents a step toward establishing a more individualized approach to ISR management.Trial registration (ClinicalTrials.gov): NCT05544864.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Small Interfering RNA (siRNA) for Cardiorenal Disease: Mechanistic Insights from Preclinical and Clinical Studies. 小干扰RNA （siRNA）用于心肾疾病：来自临床前和临床研究的机制见解。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-25 DOI: 10.1007/s12265-025-10649-4

Sukriti Wadehra, Shareen Singh, Sandeep Kaur, Amritpal Kaur, Thakur Gurjeet Singh

{"title":"Small Interfering RNA (siRNA) for Cardiorenal Disease: Mechanistic Insights from Preclinical and Clinical Studies.","authors":"Sukriti Wadehra, Shareen Singh, Sandeep Kaur, Amritpal Kaur, Thakur Gurjeet Singh","doi":"10.1007/s12265-025-10649-4","DOIUrl":"https://doi.org/10.1007/s12265-025-10649-4","url":null,"abstract":"Small Interfering RNA (siRNA) is a class of double-stranded, noncoding RNA that silences pathogenic mRNA through the process of RNA interference (RNAi). Its medical application is extensive, particularly in targeting genes associated with cardiorenal diseases, including atherosclerosis, chronic kidney disease, hypertension and cardiac failure. The pathophysiology of cardiorenal syndrome is intricate, involving a network of neurohormonal, metabolic, hemodynamic, and inflammatory interactions. Thereby, this review emphasizes the mechanistic pathways and provides evidence from preclinical and clinical studies underscoring the therapeutic potential of siRNA in the cardiorenal axis. siRNA has been shown to alleviate hemodynamic stress, reduce inflammatory cytokines and disease biomarkers. Additionally, advancements in delivery systems are explored, with a focus on overcoming challenges such as poor stability, off-target effects and limited absorption to enhance clinical applicability. This review highlights the development of siRNA-based therapeutic strategies within the cardiorenal axis, emphasizing a molecular understanding of the underlying mechanisms.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0