{"title":"Distinct Myocardial Remodelling Profiles in Athletes: A Comparative Analysis Across Sporting Disciplines.","authors":"Zayed M Altowerqi","doi":"10.1007/s12265-025-10639-6","DOIUrl":"https://doi.org/10.1007/s12265-025-10639-6","url":null,"abstract":"<p><p>Despite being recognized for over a century, the athlete's heart (AH) a result of intense and regular physical training remains a topic of clinical debate. This physiological cardiac remodelling involves structural, electrical, and functional changes that can resemble pathological conditions. In some cases, sudden cardiac death may be the first sign of underlying disease. Accurate diagnosis is crucial, but a knowledge gap often exists regarding the normal features of an athlete's heart. Clinical evaluation, including physical examination, personal and family history, and 12-lead electrocardiogram (ECG) findings, plays a key role in identifying conditions such as hypertrophic cardiomyopathy. However, distinguishing between physiological and pathological ECG changes is challenging, potentially leading to either missed diagnoses or unnecessary disqualification. This review outlines the cardiovascular adaptations to training across different athlete groups and emphasizes critical factors in assessing young competitive athletes to ensure safe participation without compromising clinical vigilance.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ming Gao, Wei Pan, Tianqi Ma, Qunyong Pen, Rong Cao, Chenxuan Zhao, Jun Yi
{"title":"The Individual and Joint Associations of Systolic Blood Pressure Variability and Arterial Stiffness with Cardiovascular Disease: A Prospective Cohort Study.","authors":"Ming Gao, Wei Pan, Tianqi Ma, Qunyong Pen, Rong Cao, Chenxuan Zhao, Jun Yi","doi":"10.1007/s12265-025-10644-9","DOIUrl":"https://doi.org/10.1007/s12265-025-10644-9","url":null,"abstract":"<p><p>Systolic blood pressure variability (SBPV) and arterial stiffness index (ASI) are risk factors for cardiovascular diseases (CVD), but their independent and combined effects remain unclear. This study investigated their associations using data from 28,792 UK Biobank participants without CVD at baseline. SBPV and ASI were categorized into quartiles, and Cox regression was used to assess their effects on CVD risk. Over an average follow-up of 12.29 years, 3,967 CVD events occurred. Higher SBPV and ASI were independently associated with increased CVD risk (SBPV Q4: HR 1.25 [1.14-1.38]; ASI Q4: HR 1.24 [1.12-1.36]). A multiplicative interaction was observed (p = 0.019), and their combined effect further elevated risk (SBPV Q4 + ASI Q4: HR 1.63 [1.32-2.02]). These findings suggest SBPV and ASI independently and jointly contribute to CVD risk, highlighting the need for targeted interventions.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yanyan Gong, Chen Zhao, Lixin Jia, Bokang Qiao, Jinwei Tian, Haichu Wen, Yuan Wang, Bo Yu, Jie Du
{"title":"Identification of Plasma Lipidomic Signatures Associated with Coronary Plaque Vulnerability.","authors":"Yanyan Gong, Chen Zhao, Lixin Jia, Bokang Qiao, Jinwei Tian, Haichu Wen, Yuan Wang, Bo Yu, Jie Du","doi":"10.1007/s12265-025-10646-7","DOIUrl":"https://doi.org/10.1007/s12265-025-10646-7","url":null,"abstract":"<p><p>The objective of this study was to identify plasma lipid signatures associated with plaque vulnerability. We retrospectively evaluated coronary plaque in 99 patients using optical coherence tomography (OCT) and quantified 489 plasma lipids. We identified intra- and inter-class crosstalk among ceramide (Cer)-phosphatidylinositol (PI)-esterified cholesterol (CE)-sphingomyelin (SM) (Cer-PI-CE-SM) in patients with thin-cap fibroatheroma (TCFA). CE-16:0, SM d18:1/16:1, and GM3 d18:1/22:0, emerged as potential markers of TCFA, correlating with the thinnest fibrous cap thickness and the presence of cholesterol crystallization. Compared to the clinical model (area under the curve [AUC] = 0.810), the AUC of the combined clinical-lipid model improved [AUC = 0.880, p = 0.032]. Calibration and decision curves demonstrated that the combined model exhibited superior diagnostic performance. We identified lipid molecules that are strongly correlated with plaque vulnerability, thus providing an option for the non-invasive identification of vulnerable plaques, which could potentially facilitate the tailored treatment for high-risk patients.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exosomal miRNAs: A New Frontier in Cardiovascular Disease Diagnosis and Treatment.","authors":"Sun Qingpiao, Zhang Yi","doi":"10.1007/s12265-025-10617-y","DOIUrl":"https://doi.org/10.1007/s12265-025-10617-y","url":null,"abstract":"<p><p>Exosomes are small vesicles secreted by a variety of cells surrounded by a lipid bilayer membrane and containing a variety of biomolecules, of which microRNAs (miRNAs) are the most abundant. Exosomal miRNAs are involved in the development of cardiovascular diseases(CVD), and their unique biological properties make them expected to be effective targets for the treatment of CVD. This article reviews the biological characteristics, expression, and mechanism of action of exosomes and exosomal miRNAs in CVD, as well as their potential as biomarkers in the diagnosis, treatment, and prognostic assessment of CVD, to provide new ideas in the field of CVD medicine.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Liwei Yu, Raquel Neves, Martijn M Bos, David J Tester, Mayank Sardana, John R Giudicessi, Michael J Ackerman
{"title":"Evaluation of CACNA1C-Positive Patients Evaluated in a Tertiary Genetic Heart Rhythm Clinic.","authors":"Liwei Yu, Raquel Neves, Martijn M Bos, David J Tester, Mayank Sardana, John R Giudicessi, Michael J Ackerman","doi":"10.1007/s12265-025-10638-7","DOIUrl":"https://doi.org/10.1007/s12265-025-10638-7","url":null,"abstract":"<p><p>Genetic variants in CACNA1C are associated with several cardiac and neurologic conditions. We conducted a retrospective review of patients evaluated and treated who presented with a pathogenic (P), likely pathogenic (LP), or variant of uncertain significance (VUS) in CACNA1C. Among 4,774 patients, 49 had P, LP, or VUS variants (55% female; median age 15 years; mean QTc 481 ms). Of these, 22 had long QT syndrome type 8, 8 had Timothy syndrome, 2 had cardiac only Timothy syndrome, and 9 had no cardiac phenotype. Ten patients exhibited extracardiac findings. Thirty-one patients were treated with a beta-blocker, 21 patients had an implantable cardioverter-defibrillator (ICD). Nine patients were on intentional non-therapy. Six patients had at least 1 breakthrough cardiac event on follow-up. Overall, CACNA1C-positive patients present with diverse diagnoses and severity. Treatments vary by phenotype, however management with preventative measures only presents a reasonable option for some phenotype-negative, genotype-positive patients.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yihua Wang, Qiang Yue, Xiurong Song, Wei Du, Rui Liu
{"title":"Hypoxia/reoxygenation-induced Glycolysis Mediates Myocardial Ischemia-reperfusion Injury Through Promoting the Lactylation of GPX4.","authors":"Yihua Wang, Qiang Yue, Xiurong Song, Wei Du, Rui Liu","doi":"10.1007/s12265-025-10628-9","DOIUrl":"https://doi.org/10.1007/s12265-025-10628-9","url":null,"abstract":"<p><p>Myocardial ischemia-reperfusion injury (MIRI) is an injury mechanism of myocardial infarction, related to ferroptosis and glycolysis. Lactate produced by glycolysis promotes protein lactylation. This study aimed to investigate the correlation between glycolysis, ferroptosis, and GPX4 lactylation in MIRI. Hypoxia/reoxygenation (H/R) increased glucose uptake, lactate production, ECAR, OCR, LDH release, lipid ROS, Fe<sup>2+</sup>, GSH, MDA contents, and cell apoptosis, and decreased GSH level in the H9C2 cells, suggesting H/R promoted glycolysis and ferroptosis. 2-DG treatment relieved the H/R-induced injury, while lactate treatment aggravated it. Besides, 2-DG suppressed lactylation of GPX4 at K218 and K228 sites and increased its protein stability. GPX4 overexpression relieved the injury caused by H/R, and alleviated cardiac injury, decreased cardiomyocyte ferroptosis in heart tissues of MIRI rats. In conclusion, GPX4 lactylation facilitated H/R-induced cardiomyocyte injury and aggravated MIRI in rats. Our findings provided new insight into targeting glycolysis and GPX4 lactylation as therapeutic strategies of MIRI.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mia Bonini, Surya Sanjay, Maximilian Balmus, Alexander Makkinejad, Katelyn Monaghan, Marc Hirschvogel, Nicholas Burris, Bo Yang, David Nordsletten
{"title":"Modeling the Hemodynamic Impact of Y-incision Aortic Annular Enlargements on Aortic Valve Replacement and Valve-in-Valve Procedures.","authors":"Mia Bonini, Surya Sanjay, Maximilian Balmus, Alexander Makkinejad, Katelyn Monaghan, Marc Hirschvogel, Nicholas Burris, Bo Yang, David Nordsletten","doi":"10.1007/s12265-025-10634-x","DOIUrl":"https://doi.org/10.1007/s12265-025-10634-x","url":null,"abstract":"<p><p>Y-incision aortic annular enlargement (Y-AAE) with surgical aortic valve replacement (SAVR) may improve outflow tract hemodynamics and valve-in-valve (ViV) outcomes but could increase thrombosis risk. We used computational fluid dynamics to analyze post-operative hemodynamics in 15 patient-specific SAVR models, comparing cases with and without Y-AAE. ViV scenarios were simulated by virtually deploying transcatheter aortic valves. Transvalvular peak velocities, pressure gradients, and blood residence time (a proxy for hemostatic risk) were analyzed to assess performance across cases. Y-AAE reduced peak velocity by 39.3% (55% in ViV), transvalvular pressure gradient by 87.2% (92% in ViV), and mean blood residence time by 10.3% (14% in ViV), with no consistent difference in maximum residence time. SAVR with Y-AAE demonstrated improved hemodynamics, even with ViV procedures, and no evidence of increased thrombosis risk.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Craig M Stolen, Molly E Kupfer, Karen Tomes, Sean Horan, Ananta Pandey, Julie Snodie, Kate Frost, Shawn Merhaut
{"title":"Redesign of Implantable Cardiac Device Workflow Improves Remote Monitoring Timeliness and Heart Failure Alert Metrics.","authors":"Craig M Stolen, Molly E Kupfer, Karen Tomes, Sean Horan, Ananta Pandey, Julie Snodie, Kate Frost, Shawn Merhaut","doi":"10.1007/s12265-025-10632-z","DOIUrl":"https://doi.org/10.1007/s12265-025-10632-z","url":null,"abstract":"<p><p>Integration into clinical workflow remains a barrier to realizing the benefits of remote heart failure monitoring technologies. A workflow redesign program was conducted at 27 cardiology sites to improve implementation of heart failure remote monitoring with HeartLogic. Device data was retrospectively retrieved from HeartLogic-capable ICDs and CRT-Ds for the 12-month periods before and after re-design. Workflow redesign led to a decrease in HeartLogic enablement time (28±110 to 10±31 days, p<0.0001) and reduction in delayed data transmissions (10% to 6%). The number of HeartLogic alert onsets per year was unchanged; however, the length of individual alerts decreased from pre- to post-redesign (47.6±38.4 to 44.1±36.5 days, p=0.001) as did the percentage of time patients spent in alert (15.5±19.9% to 14.3±19.0%, p=0.04). The maximum HeartLogic index values per alert were also lower post-redesign (28.9±12.8 vs 27.8±12.1, p=0.001). Workflow redesign improved remote monitoring utilization and heart failure alert metrics.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exercise Empowerment: A Multifaceted Anatomy in Managing Diabetic Myocardial Disorder.","authors":"Congfei Chen, Longfei Xu, Kun Wang, Tianhui Wang","doi":"10.1007/s12265-025-10630-1","DOIUrl":"https://doi.org/10.1007/s12265-025-10630-1","url":null,"abstract":"<p><p>Diabetic myocardial disorder is characterized by myocardial dysfunction in diabetes mellitus patients, independent of other heart disease causes like coronary artery disease or hypertension. This condition threatens the well-being of patients. At the cellular and molecular levels, disruptions in cardiomyocyte metabolism, abnormal calcium signaling, and increased reactive oxygen species production, among others, interconnect to create a complex pathological network that worsens myocardial cell damage and leads to cardiac dysfunction symptoms. The limited effectiveness of current pharmacological treatments has increased the appeal of non-pharmacological therapies, especially exercise therapy. Exercise is anticipated to ameliorate diabetic myocardial disease through pleiotropic beneficial effects. The fundamental mechanisms behind these benefits remain unclear; further investigation of these mechanisms will aid in developing targeted therapies. This paper aims to explore how exercise affects myocardial metabolism, antioxidant capacity, fibrosis, and microangiopathy while providing an overview of key mechanisms and recent breakthroughs to encourage ongoing research in this area.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exosomal miR-320c: A Novel Biomarker for Atrial Cardiomyopathy.","authors":"Yangcheng Xue, Zhuoran Jia, Shichu Liang, Manyu Dai, Fang Liu, Jian Wu, Ren Zhao","doi":"10.1007/s12265-025-10627-w","DOIUrl":"https://doi.org/10.1007/s12265-025-10627-w","url":null,"abstract":"<p><p>Early diagnosis and treatment of atrial cardiomyopathy(ACM) are crucial for patients with atrial fibrillation(AF), and further exploration of its biomarkers remains necessary. High-throughput sequencing of exosomal miRNAs was performed on blood samples from patients with persistent AF (PeAF) exhibiting mild and severe left atrial fibrosis, with supraventricular tachycardia (SVT) patients. Quantitative real-time reverse transcription polymerase chain reaction analysis validated differentially expressed miRNAs (DE miRNAs) from severe left atrial fibrosis PeAF, SVT and health controls. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were conducted on target genes. Four exosomal DE miRNAs were identified, including miR-5106, let-7e-5p, miR-320c, and miR-382-3p. Exosomal miR-320c was down-regulated in severe left atrial fibrosis PeAF patients, while the other three miRNAs showed no significant changes. Exosomal miR-320c emerges as a potential biomarker for severe left atrial fibrosis and ACM, suggesting its suitability as a therapeutic target.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}