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Gene Therapies in Atrial Fibrillation. 心房颤动的基因治疗。
IF 2.5 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2025-10-14 DOI: 10.1007/s12265-025-10685-0
Cian O'Donnell, Aleksei Mikhailov, Shin Yoo, Asish Ghosh, Rishi Arora
{"title":"Gene Therapies in Atrial Fibrillation.","authors":"Cian O'Donnell, Aleksei Mikhailov, Shin Yoo, Asish Ghosh, Rishi Arora","doi":"10.1007/s12265-025-10685-0","DOIUrl":"https://doi.org/10.1007/s12265-025-10685-0","url":null,"abstract":"<p><p>Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, yet current therapies-including drugs and catheter ablation-remain suboptimal. Gene therapy offers a promising way to modulate AF's molecular drivers. This review summarizes recent preclinical studies using viral and non-viral vectors, atrial-specific delivery strategies, and key targets such as ion channels, fibrosis, and oxidative stress. Despite promising results, no AF gene therapy has FDA approval, due to challenges in atrial targeting, immune control, and durable expression. Closing this translational gap is critical for future AF gene therapy.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extracellular Vesicles in Cardiovascular Diseases: Signaling, Biomarker, and Therapy. 心血管疾病中的细胞外囊泡：信号、生物标志物和治疗。
IF 2.5 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2025-10-11 DOI: 10.1007/s12265-025-10706-y
Wenxi Chen, Xinyi Zhu, Shuo Yu, Hong Ma
{"title":"Extracellular Vesicles in Cardiovascular Diseases: Signaling, Biomarker, and Therapy.","authors":"Wenxi Chen, Xinyi Zhu, Shuo Yu, Hong Ma","doi":"10.1007/s12265-025-10706-y","DOIUrl":"https://doi.org/10.1007/s12265-025-10706-y","url":null,"abstract":"<p><p>Cardiovascular diseases (CVDs) remain the global leading cause of mortality, necessitating novel diagnostics and therapies. Extracellular vesicles (EVs)-including exosomes, microvesicles, and apoptotic bodies-serve as key intercellular communicators in cardiovascular system. As carriers of bioactive miRNAs/proteins, EVs regulate inflammation, fibrogenesis, angiogenesis, and cardiac/systemic communication. Their non-invasive accessibility and disease-specific molecular signatures enable diagnostic applications. Endogenous origin and targeting capacity make EV ideal drug delivery platforms, while engineering of surface/content properties enhances their therapeutic specificity. However, key challenges persist in reproducibility, long-term safety profiles, clearance mechanisms, and therapeutic applications. Therefore, we highlight the potential of EVs as engineered drug carriers and their therapeutic promise for CVDs such as myocardial infarction, atherosclerosis, and heart failure. Future clinical translation of EV-based tools offers transformative potential-from cardiovascular diagnostics to regenerative therapies-where collaborative efforts will accelerate the pipeline development of these emerging solutions for clinical CVDs management.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasma Proteomics for Predicting Cardiovascular Disease: How Many Proteins are Enough? 血浆蛋白质组学预测心血管疾病：多少蛋白质才足够？
IF 2.5 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2025-10-10 DOI: 10.1007/s12265-025-10713-z
Patrick Royer, Elias Björnson, Martin Adiels, Anders Gummesson, Göran Bergström
{"title":"Plasma Proteomics for Predicting Cardiovascular Disease: How Many Proteins are Enough?","authors":"Patrick Royer, Elias Björnson, Martin Adiels, Anders Gummesson, Göran Bergström","doi":"10.1007/s12265-025-10713-z","DOIUrl":"https://doi.org/10.1007/s12265-025-10713-z","url":null,"abstract":"","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Machine Learning Tool to Predict Survival After First Surgery in Peripheral Artery Disease Patients. 预测外周动脉疾病患者首次手术后生存率的机器学习工具。
IF 2.5 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2025-10-08 DOI: 10.1007/s12265-025-10692-1
Martina Doneda, Ettore Lanzarone, Fabio Riccardo Pisa, Bianca Pane, Giovanni Pratesi, Giovanni Spinella
{"title":"A Machine Learning Tool to Predict Survival After First Surgery in Peripheral Artery Disease Patients.","authors":"Martina Doneda, Ettore Lanzarone, Fabio Riccardo Pisa, Bianca Pane, Giovanni Pratesi, Giovanni Spinella","doi":"10.1007/s12265-025-10692-1","DOIUrl":"https://doi.org/10.1007/s12265-025-10692-1","url":null,"abstract":"<p><p>The aim of this study was to develop and validate a machine learning tool for predicting survival in PAD patients who received surgical treatment. We used the data from 1,615 patients who underwent PAD surgery from 2005 to 2020. Gradient boosted decision trees (GBDTs) were used to predict mortality at one, three and five years after the first surgery, while predictor importance was assessed using the SHAP values method. The area under the curve (AUC) of the receiver operating characteristic curve of the one-, three and five-year prediction models were 0.86, 0.84 and 0.80, respectively. Disease stage was the most important predictor, along with age, chronic kidney disease status, hospital length-of-stay and total number of comorbidities. Presence of dyslipidemia was slightly predictive of one- and three-year mortality. Simple clinical and demographic parameters can be used to train a GBDT model capable of predicting PAD follow-up mortality.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Copper with Atherosclerosis and Treatment Strategies. 铜与动脉粥样硬化的关系及治疗策略。
IF 2.5 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2025-10-06 DOI: 10.1007/s12265-025-10697-w
Jiawei Li, Lin Yi, Lingna Zhang, Lufan Shen, Yuyuan Lu, Hong Wang, Xiaojie Chen, Yushun Kou, Yiyuan Wang, Ruiling Ma, Zhenjie Teng
{"title":"Association of Copper with Atherosclerosis and Treatment Strategies.","authors":"Jiawei Li, Lin Yi, Lingna Zhang, Lufan Shen, Yuyuan Lu, Hong Wang, Xiaojie Chen, Yushun Kou, Yiyuan Wang, Ruiling Ma, Zhenjie Teng","doi":"10.1007/s12265-025-10697-w","DOIUrl":"https://doi.org/10.1007/s12265-025-10697-w","url":null,"abstract":"<p><p>Atherosclerosis (AS) is a chronic inflammatory disease characterized by the formation of fibrous fatty lesions or plaques within the arterial wall, which causes a large amount of morbidity and mortality worldwide. Copper is a mineral nutrient essential for the human body and is essential for maintaining the normal function of multiple human systems, including the cardiovascular system. Imbalance of copper homeostasis has been increasingly considered as a key factor affecting the pathogenesis and disease progression of AS. This article summarizes the complex association between copper ions and AS, focusing in particular on the key roles of copper metabolism, copper homeostasis and copper death. It aims to reveal the mechanism of action of copper ions in AS and explore treatment strategies targeting copper metabolism, copper death and copper homeostasis imbalance in relation to atherosclerosis, with a view to providing new perspectives and strategies for the treatment and prevention of AS.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MYC-CXCL1-CXCR2 Axis in Heart Failure-Specific Cardiac Fibroblasts: a Potential Novel Therapeutic Target Beyond Cardiomyocytes. 心衰特异性心脏成纤维细胞MYC-CXCL1-CXCR2轴：心肌细胞之外的潜在新治疗靶点
IF 2.5 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2025-10-02 DOI: 10.1007/s12265-025-10708-w
Yuwei Yan, Shuyi Qiu, Juan Gao, Junjie Xiao
{"title":"MYC-CXCL1-CXCR2 Axis in Heart Failure-Specific Cardiac Fibroblasts: a Potential Novel Therapeutic Target Beyond Cardiomyocytes.","authors":"Yuwei Yan, Shuyi Qiu, Juan Gao, Junjie Xiao","doi":"10.1007/s12265-025-10708-w","DOIUrl":"https://doi.org/10.1007/s12265-025-10708-w","url":null,"abstract":"","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FGF21 Blunts Cardiac Ischemia/Reperfusion Injury by Promoting Autophagic Flux Via Stat1/Irgm1 Pathway. FGF21通过Stat1/Irgm1通路促进自噬通量减轻心脏缺血/再灌注损伤
IF 2.5 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2025-10-02 DOI: 10.1007/s12265-025-10707-x
Tao Tu, Zuodong Ning, Yuhu He, Yingxu Ma, Yichao Xiao, Zhaowei Zhu, Liang Tang, Xuping Li, Hui Yang, Mingxian Chen, Shi Tai, Qiming Liu, Shenghua Zhou
{"title":"FGF21 Blunts Cardiac Ischemia/Reperfusion Injury by Promoting Autophagic Flux Via Stat1/Irgm1 Pathway.","authors":"Tao Tu, Zuodong Ning, Yuhu He, Yingxu Ma, Yichao Xiao, Zhaowei Zhu, Liang Tang, Xuping Li, Hui Yang, Mingxian Chen, Shi Tai, Qiming Liu, Shenghua Zhou","doi":"10.1007/s12265-025-10707-x","DOIUrl":"https://doi.org/10.1007/s12265-025-10707-x","url":null,"abstract":"<p><p>This study aimed to investigate the underlying mechanisms of Fibroblast Growth Factor 21 (FGF21) in myocardial ischemia/reperfusion (I/R) injury. First, FGF21 was upregulated in the serum of patients with myocardial I/R injury as well as in I/R hearts of mice and hypoxia/reoxygenation (H/R) neonatal rat cardiomyocytes (NRCMs). While FGF21 knockout exacerbated such injury, which was mitigated by rhFGF21. Bioinformatics analysis identified immunity-related GTPase M1 (Irgm1) as a key autophagy-related gene downregulated in ventricular tissue of FGF21<sup>-/-</sup> I/R mice. Impaired autophagic flux in FGF21<sup>-/-</sup> mice during I/R could be rescued by rhFGF21 through the signal transducers and activators of transcription 1 (STAT1) pathway. The beneficial effects of rhFGF21 in reducing H/R injury were limited in Irgm1 knockdown NRCMs. This study suggested that FGF21 deficiency intensifies myocardial I/R injury by exacerbating the impairment of autophagic flux. Activation of FGF21 or Irgm1 may serve as a promising therapeutic strategy for myocardial I/R injury.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing Ulk1-Ser913 Phosphorylation as a Novel Therapy for Cardiac Aging. 增强Ulk1-Ser913磷酸化作为心脏衰老的新疗法。
IF 2.5 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2025-10-02 DOI: 10.1007/s12265-025-10709-9
Yuwei Yan, Xinyi Ren, Tingting Yang, Junjie Xiao
{"title":"Enhancing Ulk1-Ser913 Phosphorylation as a Novel Therapy for Cardiac Aging.","authors":"Yuwei Yan, Xinyi Ren, Tingting Yang, Junjie Xiao","doi":"10.1007/s12265-025-10709-9","DOIUrl":"https://doi.org/10.1007/s12265-025-10709-9","url":null,"abstract":"","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LncRNA SMILR Serves a Diagnostic Biomarker in Patients with Chronic Heart Failure and Regulates Functions of Vascular Endothelial Cells. LncRNA SMILR可作为慢性心力衰竭患者的诊断生物标志物并调节血管内皮细胞的功能
IF 2.5 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2025-10-01 DOI: 10.1007/s12265-025-10702-2
Jie Yan, Zheng Tian, Bingyan Guo
{"title":"LncRNA SMILR Serves a Diagnostic Biomarker in Patients with Chronic Heart Failure and Regulates Functions of Vascular Endothelial Cells.","authors":"Jie Yan, Zheng Tian, Bingyan Guo","doi":"10.1007/s12265-025-10702-2","DOIUrl":"https://doi.org/10.1007/s12265-025-10702-2","url":null,"abstract":"<p><p>Investigated the role and possible mechanisms of SMILR in angiogenesis among chronic heart failure (CHF) patients to establish novel biomarkers for the clinical assessment of CHF. qPCR was employed to assess the levels of serum SMILR and miR-10b-3p. ROC analysis and logistic regression were utilized to evaluate the diagnostic and predictive value of SMILR. Pearson correlation analysis was conducted to explore the relationship between serum SMILR and myocardial injury markers, as well as cardiac function indicators. In CHF patients, serum SMILR was up-regulated, while miR-10b-3p was down-regulated. In a hypoxic injury model, SMILR silencing restored both the function and oxidative stress levels of hCMECs, and promoted the secretion of pro-angiogenic factors. Inhibition of miR-10b-3p prevented the angiogenic enhancement associated with the knockdown of SMILR. SMILR influences angiogenesis and CHF progression via miR-10b-3p. SMILR is a promising candidate for early detection and subsequent therapy in CHF.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A MATLAB Algorithm to Automatically Estimate the QT Interval and Other ECG Parameters and Validation Using a Machine Learning Approach in Congenital Long-QT Syndrome. 先天性长QT综合征QT间期及其他心电图参数自动估计的MATLAB算法及机器学习方法验证。
IF 2.5 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2025-09-30 DOI: 10.1007/s12265-025-10693-0
Elinor Tzvi-Minker, Sven Dittmann, Corinna Rickert, Andreas Keck, Eric Schulze-Bahr
{"title":"A MATLAB Algorithm to Automatically Estimate the QT Interval and Other ECG Parameters and Validation Using a Machine Learning Approach in Congenital Long-QT Syndrome.","authors":"Elinor Tzvi-Minker, Sven Dittmann, Corinna Rickert, Andreas Keck, Eric Schulze-Bahr","doi":"10.1007/s12265-025-10693-0","DOIUrl":"https://doi.org/10.1007/s12265-025-10693-0","url":null,"abstract":"<p><p>Myocardial repolarization and QT duration are crucial markers for diagnosis and monitoring of congenital long QT syndrome (LQTS). Here we present a novel algorithm to automatically estimate the QT interval based on Lepeschkin's tangent method, as well as parameters underlying T-wave morphology in digital electrocardiograms (ECGs) of 466 patients with LQTS. The algorithm's performance was validated using ECG data from 40 healthy controls. The results were compared against expert measurement of the QT interval, as well as against the results of the ECG device MUSE™ system. Applying an optimizable Support Vector Machine classifier on the algorithm's outcomes achieved an accuracy of 78.1% and area under the curve of 0.85 in classifying LQTS patients with a prolonged QTc interval (upon QT_GS) from those with a normal QTc interval. The presented MATLAB®-based algorithm offers a transparent and reproducible approach to automatic QT interval estimation and QTc calculation in LQTS patients, potentially improving automatized screening, diagnostic precision and patient management.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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