Journal of Cardiovascular Translational Research最新文献

HNMT: A Key Pro-hypertrophic Factor in Pressure Overload. HNMT：压力过载的关键促肥厚因子。

IF 2.5 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2026-05-03 DOI: 10.1007/s12265-026-10775-7

Hang Chen, Yifu Chen, Shihui Zang, Xuerui Chen, Junjie Xiao

引用次数: 0

Scoping Review on True and Relative Bradycardia in Trauma: How to Approach Bradycardia in Traumatic Brain Injury. 创伤中真性和相对性心动过缓的范围综述：如何处理创伤性脑损伤中的心动过缓。

IF 2.5 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2026-04-27 DOI: 10.1007/s12265-026-10772-w

Ayman El-Menyar, Naushad A Khan, Abdul Rehman Abid, Eman Elmenyar, Hassan Al-Thani

{"title":"Scoping Review on True and Relative Bradycardia in Trauma: How to Approach Bradycardia in Traumatic Brain Injury.","authors":"Ayman El-Menyar, Naushad A Khan, Abdul Rehman Abid, Eman Elmenyar, Hassan Al-Thani","doi":"10.1007/s12265-026-10772-w","DOIUrl":"https://doi.org/10.1007/s12265-026-10772-w","url":null,"abstract":"Brain-heart interactions have garnered considerable interest in the landscape of traumatic brain injury (TBI). This scoping review focused on bradycardia caused by high intracranial pressure (ICP), brainstem injury, autonomic imbalance, hypothalamic-pituitary-adrenal axis disruption, or massive bleeding. The latter condition is attributed to a physiological phenomenon called relative bradycardia (RB). True bradycardia results from underlying physiological or pathological cardiac disorders, whereas RB has different definitions and implications in medical and surgical settings. The former reflects pulse-temperature dissociation, while the latter reflects pulse-pressure dissociation. However, it can reflect an abnormal neurological response called the Cushing reflex. Therefore, bradycardia may indicate imminent shock after TBI associated with torso injuries or high ICP following severe isolated TBI. RB is underrecognized and underappreciated in emergency settings. This review investigated whether RB affects patient survival and neurological function. Physicians should approach patients presenting with RB with a high index of suspicion and timely management.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":"19 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13121324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nuclear eNOS-ADAR1 Signaling in Endothelial Immunoregulation. 细胞核eNOS-ADAR1信号在内皮细胞免疫调节中的作用。

IF 2.5 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2026-04-18 DOI: 10.1007/s12265-026-10770-y

Siqi Wang, Yifu Chen, Shihui Zang, Tingting Yang, Junjie Xiao

引用次数: 0

New Advances in the Mechanisms and Therapeutic Strategies of Gut Microbiota in Regulating Glycolipid Metabolism to Combat Atherosclerosis. 肠道菌群调节糖脂代谢对抗动脉粥样硬化机制及治疗策略的新进展。

IF 2.5 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2026-04-15 DOI: 10.1007/s12265-026-10768-6

Hui Zhang, Pihong Liu, Naizhi Geng

{"title":"New Advances in the Mechanisms and Therapeutic Strategies of Gut Microbiota in Regulating Glycolipid Metabolism to Combat Atherosclerosis.","authors":"Hui Zhang, Pihong Liu, Naizhi Geng","doi":"10.1007/s12265-026-10768-6","DOIUrl":"https://doi.org/10.1007/s12265-026-10768-6","url":null,"abstract":"Atherosclerosis is the major pathological basis of cardiovascular diseases, characterized by chronic inflammation and disturbed glucose and lipid metabolism. Despite the widespread use of statins, the global clinical burden continues to rise, and effective therapeutic strategies remain limited. As the \"second genome,\" gut microbiota participates in the progression of atherosclerosis by regulating host glucose and lipid metabolism, inflammatory responses, and metabolite production. Natural plant components exert multiple effects, including regulating glucose and lipid metabolism, modulating gut microbiota, and anti-inflammatory activity, showing unique advantages in the prevention and treatment of atherosclerosis. This review summarizes the mechanisms underlying the anti-atherosclerotic effects of gut microbiota via regulating glucose and lipid metabolism, as well as the role of natural plant components in intervening disease progression by remodeling intestinal microecology and reducing pro-atherogenic metabolites. It provides a theoretical basis for novel therapeutic strategies targeting gut microbiota and the clinical application of plant components.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":"19 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Traditional Chinese Medicine Targeting Ferroptosis in Cardiovascular Diseases: Advances and Perspectives. 中医药治疗心血管疾病铁下垂的研究进展与展望

IF 2.5 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2026-04-15 DOI: 10.1007/s12265-026-10769-5

Jianing Wang, Yuetong Li, Yuan Liu, Zihui Zhang, Heng Ma

引用次数: 0

Mechanistic Insights into Therapeutic Strategies for Post- Menopausal Atherosclerosis: Evidence from an Ovariectomized Mouse Model. 绝经后动脉粥样硬化治疗策略的机制见解：来自卵巢切除小鼠模型的证据。

IF 2.5 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2026-03-30 DOI: 10.1007/s12265-026-10766-8

Siti Bazilah Zulkefli, Fathimah Mohamad, Nurul Alimah Abdul Nasir, Ahmad Nazrun Shuid, Nasibah Azme

{"title":"Mechanistic Insights into Therapeutic Strategies for Post- Menopausal Atherosclerosis: Evidence from an Ovariectomized Mouse Model.","authors":"Siti Bazilah Zulkefli, Fathimah Mohamad, Nurul Alimah Abdul Nasir, Ahmad Nazrun Shuid, Nasibah Azme","doi":"10.1007/s12265-026-10766-8","DOIUrl":"https://doi.org/10.1007/s12265-026-10766-8","url":null,"abstract":"Atherosclerosis in postmenopausal women is a significant cardiovascular complication that is caused by estrogen deficiency, leading to increased inflammation and oxidative stress, and dysregulated lipid metabolism. The review summarizes the evidence gathered in ovariectomized mice models in order to determine mechanistic associations between different pharmacological therapeutic strategies and their impact on the progression of atherosclerosis in postmenopausal conditions. This review builds on an upstream hormonal signaling framework model of estrogen receptor-mediated pathways and the three main downstream mechanistic pillars: lipid handling, inflammatory and oxidative stress pathways, and endothelial homeostasis. In this framework context, downstream consequence mechanisms, including PCSK9 regulation and ferroptosis, are analyzed along with emerging evidence linking estrogen deficiency to modulation of the gut microbiota. The evidence shows the complex interconnections among hormonal, metabolic, and vascular processes underlying postmenopausal atherosclerosis, providing a translational framework for applying therapeutic interventions.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":"19 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Baicalin Attenuates Oxidative Stress and Apoptosis in Myocardial Ischemia/reperfusion Injury via Suppression of STING/NLRP3 Pathway. 黄芩苷通过抑制STING/NLRP3通路减轻心肌缺血/再灌注损伤的氧化应激和细胞凋亡

IF 2.5 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2026-03-27 DOI: 10.1007/s12265-026-10765-9

Qi Li, Jiaxin Wang, Yilong Jiang, Fei Wang, Ming Liu, Donghong Yang, Xu Yan, Yue Wang, Haozhen Du, Qingsheng You, Kun Liu

{"title":"Baicalin Attenuates Oxidative Stress and Apoptosis in Myocardial Ischemia/reperfusion Injury via Suppression of STING/NLRP3 Pathway.","authors":"Qi Li, Jiaxin Wang, Yilong Jiang, Fei Wang, Ming Liu, Donghong Yang, Xu Yan, Yue Wang, Haozhen Du, Qingsheng You, Kun Liu","doi":"10.1007/s12265-026-10765-9","DOIUrl":"https://doi.org/10.1007/s12265-026-10765-9","url":null,"abstract":"Ischemic heart disease, as one of the major causes of morbidity worldwide, there is no effective therapy for preventing myocardial ischemia-reperfusion injury (MIRI). Baicalin, a flavonoid glycoside extracted from the Scutellaria baicalensis Georgi, yet its effects in MIRI remain unclear. In the study, pretreatment with Baicalin (100 mg/kg, i.p.) markedly alleviated I/R-induced cardiac dysfunction, as shown by reduced serum lactate dehydrogenase (LDH), creatine kinase (CK), and myocardial infarction. Baicalin also improved cardiomyocyte survival by increasing Bcl-2 and decreasing Bax and caspase-3/9 levels. In addition, Baicalin suppressed oxidative stress by reducing malondialdehyde (MDA) while elevating glutathione (GSH) and superoxide dismutase (SOD) levels. Moreover, Baicalin inhibited the STING, NLRP3, cleaved caspase-1, IL-18, and IL-1β expression in vivo and in vitro. Crucially, amidobenzimidazole (ABZI), a STING agonist, reversed the cardioprotective effects of Baicalin. Collectively, these findings demonstrated that Baicalin exerted cardioprotective effects by attenuating apoptosis and oxidative stress through suppression of STING/NLRP3 activation.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":"19 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147529318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ALDH2/eIF3E as Novel Regulators of Cardiac Ferroptosis. ALDH2/eIF3E：心脏铁下垂的新调控因子

IF 2.5 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2026-03-25 DOI: 10.1007/s12265-026-10767-7

Siqi Wang, Shuqin Liu, Sihui Zang, Tingting Yang, Junjie Xiao

引用次数: 0

The Gut Metabolite Phenylacetylglutamine Inhibits the Angiogenic Potential of Human Umbilical Vein Endothelial Cells Via the β-Adrenergic Receptor-LDHA Axis. 肠道代谢物苯乙酰谷氨酰胺通过β-肾上腺素能受体- ldha轴抑制人脐静脉内皮细胞的血管生成潜能。

IF 2.5 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2026-03-24 DOI: 10.1007/s12265-026-10764-w

Yin Zhang, Wenlong Yang, Jinyan Zhang, Jixiang A, Jinye Shen, Zhiyong Qi, Juying Qian, Aijun Sun, Junbo Ge, Shuning Zhang

{"title":"The Gut Metabolite Phenylacetylglutamine Inhibits the Angiogenic Potential of Human Umbilical Vein Endothelial Cells Via the β-Adrenergic Receptor-LDHA Axis.","authors":"Yin Zhang, Wenlong Yang, Jinyan Zhang, Jixiang A, Jinye Shen, Zhiyong Qi, Juying Qian, Aijun Sun, Junbo Ge, Shuning Zhang","doi":"10.1007/s12265-026-10764-w","DOIUrl":"10.1007/s12265-026-10764-w","url":null,"abstract":"Phenylacetylglutamine (PAGln), a gut microbiota-derived metabolite, is associated with enhanced thrombosis. However, its impact on endothelial function and angiogenesis remains unclear. A murine hindlimb ischemia model was used to assess perfusion recovery. Human umbilical vein endothelial cell (HUVEC) proliferation, migration, and tube formation were evaluated in vitro. Gene set enrichment analysis (GSEA) was performed for pathway enrichment analyses. Furthermore, glycolytic flux and enzyme expression were measured. Lentiviral lactate dehydrogenase A (LDHA) overexpression was performed both in vitro and in vivo. Elevated PAGln impaired blood flow recovery and inhibited HUVEC proliferation, migration and tube formation. β-receptor blocker zenidolol was able to reverse the adverse effects. PAGln downregulated glycolytic pathways, reduced proton efflux, and suppressed LDHA expression and lactate production. LDHA overexpression rescued PAGln-induced angiogenic impairment. The gut metabolite PAGln may suppress angiogenesis of HUVEC by targeting the β-receptors, subseqeuently inhibiting LDHA expression.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":"19 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13013128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147512354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Microbial Mechanisms of Cardiovascular Disease: Oral Dysbiosis as a Systemic Instigator. 心血管疾病的微生物机制：口腔生态失调是一个系统性诱因。

IF 2.5 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2026-03-12 DOI: 10.1007/s12265-026-10761-z

Laresh N Mistry, Sumeet Agarwal, Sankalp Dattaram Bhandarkar, Vivek Sharma, Himmat Jaiswal, Saudamini More

引用次数: 0