Journal of Cardiovascular Translational Research最新文献

Cardiac Magnetic Resonance-Derived Left Ventricular Mechanical Dispersion Improves Risk Stratification of Hypertrophic Cardiomyopathy and its Correlations with Scar Heterogeneity. 心脏磁共振衍生的左心室机械离散度改善肥厚性心肌病的风险分层及其与疤痕异质性的相关性。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-02 DOI: 10.1007/s12265-025-10631-0

Xiaoying Zhao, Yujiao Song, Li Zhang, Lujing Wang, Xinxiang Zhao, Jin Wang

{"title":"Cardiac Magnetic Resonance-Derived Left Ventricular Mechanical Dispersion Improves Risk Stratification of Hypertrophic Cardiomyopathy and its Correlations with Scar Heterogeneity.","authors":"Xiaoying Zhao, Yujiao Song, Li Zhang, Lujing Wang, Xinxiang Zhao, Jin Wang","doi":"10.1007/s12265-025-10631-0","DOIUrl":"https://doi.org/10.1007/s12265-025-10631-0","url":null,"abstract":"The accuracy of prevalent risk models recommended by American Heart Association/American College of Cardiology(AHA/ACC) and European Society of Cardiology(ESC) for hypertrophic cardiomyopathy(HCM) patients is suboptimal. We assessed the utility of cardiac magnetic resonance(CMR)-3D left ventricular mechanical dispersion(LVMD) in the prognostic stratification of 159 HCM and explore the correlation with myocardial fibrosis heterogeneity. Entropy demonstrated linear correlations with 3D LVMD. Patients experienced endpoint events exhibited significantly higher radial LVMD(LVMD-R), circumferential LVMD(LVMD-C), and longitudinal LVMD(LVMD-L). Kaplan-Meier analyses demonstrated that HCM patients with elevated LVMD had a higher risk of primary and secondary endpoint events. In multivariable Cox analysis incorporated the guidelines risk classification, both LVMD-C and LVMD-L emerged as significant predictors for endpoint events. We developed a model incorporated the 2022 ESC risk stratification in combination with LVMD-C and LVMD-L and revealed that combined model significantly outperformed the guidelines alone. Additionally, entropy demonstrated linear correlations with LVMD.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endothelial Glycocalyx Damage and Restoration Following Vascular Stent Implantation. 血管支架植入术后内皮糖萼损伤与修复。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-02 DOI: 10.1007/s12265-025-10633-y

Belay Tesfamariam

{"title":"Endothelial Glycocalyx Damage and Restoration Following Vascular Stent Implantation.","authors":"Belay Tesfamariam","doi":"10.1007/s12265-025-10633-y","DOIUrl":"https://doi.org/10.1007/s12265-025-10633-y","url":null,"abstract":"The endothelial glycocalyx layer forms interface between the luminal surface and circulating blood, and consists of cell surface membrane-bound glycosaminoglycan chains and transmembrane embedded glycoproteins and proteoglycans, such as glypicans and syndecans. This dynamic layer contributes to various endothelial functions, including maintenance of vascular permeability, mechanosensation, shear-stress-mediated nitric oxide generation, modulation of interactions with constituents of blood, and regulation of vascular tone. Following vascular device placement, the transmembrane-linked glycosaminoglycan side chains are damaged and released into the circulation as soluble heparan sulfate, hyaluronan, and chondroitin sulfate. Damage to the glycocalyx causes an increase in vascular permeability, adhesion of leukocytes and platelets to the endothelium, extravasation of proinflammatory cells, dysregulation of vascular tone, imbalance of coagulation, and loss of antioxidant defense mechanisms. This review highlights the function of the endothelial glycocalyx as a vasoprotective layer and discusses targeted therapeutic approaches to promoting the restoration of glycocalyx disrupted by vascular stent implantation.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular Vesicles as Diagnostic Metrics for Cardiovascular Disease: Where We are and How to Achieve in Clinics. 细胞外囊泡作为心血管疾病的诊断指标：我们在哪里以及如何在临床中实现。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-02 DOI: 10.1007/s12265-025-10629-8

Yujia Wang, Yingxue Yuan, Junnan Tang

引用次数: 0

The Clinical Significance of miR-139-5p in Acute Coronary Syndrome and its Potential Effect on the Progression of Acute Coronary Syndrome. miR-139-5p在急性冠脉综合征中的临床意义及其对急性冠脉综合征进展的潜在影响

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-05-29 DOI: 10.1007/s12265-025-10625-y

Zhe Wang, Qiaoli Ma, Fei Lin

{"title":"The Clinical Significance of miR-139-5p in Acute Coronary Syndrome and its Potential Effect on the Progression of Acute Coronary Syndrome.","authors":"Zhe Wang, Qiaoli Ma, Fei Lin","doi":"10.1007/s12265-025-10625-y","DOIUrl":"https://doi.org/10.1007/s12265-025-10625-y","url":null,"abstract":"To investigate the role of miR-139-5p in acute coronary syndrome (ACS), serum miR-139-5p levels were measured via quantitative real-time polymerase chain reaction (qRT-PCR) in 117 ACS patients, 91 stable angina (SAP) patients, 89 healthy controls. Its associations with ACS severity, major adverse cardiovascular events (MACE) were evaluated using statistical tests, Kaplan-Meier survival, COX regression analysis. Effect of miR-139-5p on cell function and inflammation in oxidized low-density lipoprotein (ox-LDL) -induced human coronary artery smooth muscle cells (HCASMCs) was evaluated in vitro. Upregulated miR-134-5p in ACS distinguished ACS from SAP/health individuals, correlating with increased cardiac troponin I (cTnI), Gensini score, MACE risk. COX regression identified miR-139-5p as independent ACS prognostic factors. In vitro, miR-139-5p downregulation suppressed ox-LDL-induced HCASMC proliferation, migration, and inflammation. Upregulated miR-139-5p expression showed a diagnostic and prognostic value on ACS and was correlated with ACS severity. Downregulated miR-139-5p expression exhibited a suppressive effect on ACS progression.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Randomised Comparison of Culotte- versus Double Kissing Crush Stenting in de novo non-left Main Coronary Bifurcation Lesions: Rationale and Design of the Bifurcation Bad Krozingen trial-3 (BBK-3). 冠状动脉非左主干分叉病变的随机比较：分叉Bad Krozingen试验-3 （BBK-3）的原理和设计。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-05-27 DOI: 10.1007/s12265-025-10626-x

Faridun Rahimi, Nikolaus Löffelhardt, Jan Minners, Philipp Breitbart, Kilian Franke, Tau Sarra Hartikainen, Christian Valina, Constantin V Zur Mühlen, Thomas Nührenberg, Adnan Kastrati, Felix Woitek, Albrecht Elsaesser, Mohamed Abdel-Wahab, Samuel Sossalla, Willibald Hochholzer, Dirk Westermann, Franz-Josef Neumann, Christoph Olivier, Miroslaw Ferenc

{"title":"Randomised Comparison of Culotte- versus Double Kissing Crush Stenting in de novo non-left Main Coronary Bifurcation Lesions: Rationale and Design of the Bifurcation Bad Krozingen trial-3 (BBK-3).","authors":"Faridun Rahimi, Nikolaus Löffelhardt, Jan Minners, Philipp Breitbart, Kilian Franke, Tau Sarra Hartikainen, Christian Valina, Constantin V Zur Mühlen, Thomas Nührenberg, Adnan Kastrati, Felix Woitek, Albrecht Elsaesser, Mohamed Abdel-Wahab, Samuel Sossalla, Willibald Hochholzer, Dirk Westermann, Franz-Josef Neumann, Christoph Olivier, Miroslaw Ferenc","doi":"10.1007/s12265-025-10626-x","DOIUrl":"https://doi.org/10.1007/s12265-025-10626-x","url":null,"abstract":"Whether culotte or double kissing (DK)-crush stenting is the superior systematic 2-stent technique in non-left main bifurcation lesions is unclear. The BBK-3 (unique identifier NCT04192760) is a multicenter, prospective, randomized controlled trial to test the hypothesis that culotte stenting reduces maximal percent diameter restenosis at 9-month follow-up compared to DK-crush stenting in de-novo non-left main coronary bifurcation lesions using approved, third-generation drug-eluting stents (DES). A total of 400 patients will be randomized in a 1:1 ratio to receive a two-stent strategy. The primary study endpoint is the maximal percent diameter in-stent restenosis within the bifurcation at 9 months, assessed by quantitative coronary angiography. Secondary endpoints include target lesion revascularization (TLR), the composite of death and myocardial infarction, emergent cardiac bypass surgery and TLR (MACE) at 12 months. BBK-3 will assist in the identification of the preferable, contemporary 2-stent strategy in the treatment of de-novo non-left main coronary bifurcation lesions.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Angiography-Derived Computational Coronary Flow Reserve to Evaluate Non-Obstructive Coronary Artery Disease. 一种新的基于血管造影的计算冠状动脉血流储备评估非阻塞性冠状动脉疾病。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-05-19 DOI: 10.1007/s12265-025-10608-z

Jingpu Wang, Yumeng Hu, Xinyi Yang, Rende Xu, Zhangwei Chen, Zhe Wang, Leilei Ma, Feng Zhang, Xiaochang Leng, Junbo Ge, Jianping Xiang, Chenguang Li

{"title":"A Novel Angiography-Derived Computational Coronary Flow Reserve to Evaluate Non-Obstructive Coronary Artery Disease.","authors":"Jingpu Wang, Yumeng Hu, Xinyi Yang, Rende Xu, Zhangwei Chen, Zhe Wang, Leilei Ma, Feng Zhang, Xiaochang Leng, Junbo Ge, Jianping Xiang, Chenguang Li","doi":"10.1007/s12265-025-10608-z","DOIUrl":"https://doi.org/10.1007/s12265-025-10608-z","url":null,"abstract":"Coronary flow reserve (CFR) is a key parameter for risk stratification in coronary artery disease but is limited by high cost, prolonged procedure time, and suboptimal reproducibility. We proposed a novel angiography-based method (Angio-CFR) to overcome these challenges and assessed its diagnostic performance. 107 consecutive patients underwent invasive coronary angiography with thermodilution-derived CFR (CFRthermo) were prospectively enrolled. Flow velocity at hyperemia and rest was estimated from angiographic images, and Angio-CFR was calculated as their ratio. Angio-CFR correlated well with CFRthermo (r = 0.72, p < 0.001), and showed good discrimination of CFRthermo < 2.5 (AUC = 0.879, p < 0.001) with an optimal cut-off of 2.5. The accuracy, sensitivity, and specificity of Angio-CFR were 81.71%, 83.33%, and 81.25%, respectively. Angio-CFR provides a pressure-wire-free method for coronary function assessment, demonstrating promising diagnostic accuracy and offering a more accessible approach for CFR measurement in clinical practice.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validity and Reproducibility of the Six-Minute Stepper Test in Cardiac Patients. 心脏病患者6分钟步进试验的有效性和可重复性。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-05-08 DOI: 10.1007/s12265-025-10624-z

Michaël Racodon, Claudine Fabre, Pierre Vanhove, Jordan Do Vale, Romain Bolpaire, Elodie Moutailler, Félicité Malanda, Amandine Secq

引用次数: 0

Plasma Small Extracellular Vesicles of Ischemic Cardiomyopathy Aggravate Ventricular Remodeling Post-Myocardial Infarction and Promote miR-223-3p-mediated Dysfunction in Regulatory T Cells. 缺血性心肌病的血浆小细胞外泡加重心肌梗死后心室重构，促进mir -223-3p介导的调节性T细胞功能障碍

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-05-08 DOI: 10.1007/s12265-025-10623-0

Bifang Mai, Wenlong Jiang, Jing Yang, Yuyang Chen, Zhen Qin, Yuan Li, Wenqing Tu, Yuhan Lin, Wai Seng Chan, Jianhua Wu, Fangzhou Cheng, Tao Xu, Shuanglun Xie

{"title":"Plasma Small Extracellular Vesicles of Ischemic Cardiomyopathy Aggravate Ventricular Remodeling Post-Myocardial Infarction and Promote miR-223-3p-mediated Dysfunction in Regulatory T Cells.","authors":"Bifang Mai, Wenlong Jiang, Jing Yang, Yuyang Chen, Zhen Qin, Yuan Li, Wenqing Tu, Yuhan Lin, Wai Seng Chan, Jianhua Wu, Fangzhou Cheng, Tao Xu, Shuanglun Xie","doi":"10.1007/s12265-025-10623-0","DOIUrl":"https://doi.org/10.1007/s12265-025-10623-0","url":null,"abstract":"Treg dysfunction in ischemic cardiomyopathy (ICM) remains mechanistically unclear. We investigated ICM plasma small extracellular vesicles (ICM-sEVs) in Treg regulation and post-MI remodeling. Flow cytometry assessed Treg frequency. ICM-sEV miRNA sequencing revealed miR-223-3p enrichment, validated using miR-223-/- and Foxp3GFP/+ mice. ICM patients and mice exhibited elevated Treg numbers but suppressed Foxp3. miR-223-3p was upregulated in ICM-sEVs and inversely correlated with functional Tregs. ICM-sEVs administration aggravated ventricular remodeling post myocardial infarction (MI) in mice while reducing Treg frequency and elevating miR-223-3p in vitro. miR-223 knockdown increased Treg cell number and Foxp3 expression, whereas miR-223 overexpression reversed the phenotype. ICM-sEVs aggravate ventricular remodeling post-MI and promote miR-223-3p-mediated Treg cell dysfunction.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LACC1 Enhances Polyamine Immunometabolism in Inflammatory Macrophages to Inhibit Atherosclerosis Progression. LACC1增强炎性巨噬细胞多胺免疫代谢抑制动脉粥样硬化进展

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-04-28 DOI: 10.1007/s12265-024-10585-9

Jingyong Zhang, Yuan Xu, Zonglin Han, Bingqi Liu, Maohua Wang, Lili Bao, Yuxiang He

{"title":"LACC1 Enhances Polyamine Immunometabolism in Inflammatory Macrophages to Inhibit Atherosclerosis Progression.","authors":"Jingyong Zhang, Yuan Xu, Zonglin Han, Bingqi Liu, Maohua Wang, Lili Bao, Yuxiang He","doi":"10.1007/s12265-024-10585-9","DOIUrl":"https://doi.org/10.1007/s12265-024-10585-9","url":null,"abstract":"To explore the function and potential mechanism of laccase domain-containing 1 (LACC1) on atherosclerosis (AS). ApoE-/- mice feed with high-fat diet (HFD) were injected with adenovirus shLACC1 (Ad-shLACC1) or Ad-shNC via tail vein. LACC1 was highly expressed in macrophages of atherosclerotic plaque in ApoE-/- mice and ox-LDL-treated Raw264.7 macrophages. LACC1 silencing enhanced AS development and facilitated inflammation in mice. Then, we found that LACC1 silencing facilitated inflammation but repressed polyamine immunometabolism in ox-LDL-treated Raw264.7 macrophages. Through rescue experiments using ornithine or ODC1 inhibitor (DFMO), we further confirmed that LACC1 promoted polyamine immunometabolism to inhibit inflammation in ox-LDL-treated Raw264.7 macrophages. In addition, the observed LACC1 function was dependent on NOS2. In conclusion, we proved that the downregulation of LACC1 promoted AS progression via inhibiting polyamine immunometabolism in inflammatory macrophages, suggesting LACC1 may be a potential therapeutic target for AS.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of The Relationship Between Differential Small Molecule Peptides in Peripheral Blood and Arteriosclerosis in Patients with Essential Hypertension. 高血压患者外周血差异小分子肽与动脉硬化关系的研究。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-04-22 DOI: 10.1007/s12265-025-10616-z

Yunfeng Fang, Jingwen Yue, Min Zhang, Li Jiang

引用次数: 0