Journal of Cardiovascular Translational Research最新文献

CNDP2: An Enzyme Linking Metabolism and Cardiovascular Diseases? CNDP2：连接新陈代谢和心血管疾病的酶？

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-09-30 DOI: 10.1007/s12265-024-10560-4

Moizle Grace Castro Ocariza, Louise Nancy Paton, Evelyn Mary Templeton, Christopher Joseph Pemberton, Anna Pauline Pilbrow, Sarah Appleby

{"title":"CNDP2: An Enzyme Linking Metabolism and Cardiovascular Diseases?","authors":"Moizle Grace Castro Ocariza, Louise Nancy Paton, Evelyn Mary Templeton, Christopher Joseph Pemberton, Anna Pauline Pilbrow, Sarah Appleby","doi":"10.1007/s12265-024-10560-4","DOIUrl":"https://doi.org/10.1007/s12265-024-10560-4","url":null,"abstract":"The heart requires a substantial amount of energy to function, utilising various substrates including lipids, glucose and lactate as energy sources. In times of increased stress, lactate becomes the primary energy source of the heart, but persistently elevated lactate levels are linked to poor patient outcomes and increased mortality. Recently, carnosine dipeptidase II (CNDP2) was discovered to catalyse the formation of Lac-Phe, an exercise-induced metabolite derived from lactate, which has been shown to suppress appetite in mice and reduce adipose tissue in humans. This review discusses CNDP2, including its role in lactate clearance, carnosine hydrolysis, oxidative stress regulation, and involvement in metabolite regulation. The association between CNDP2 and cardiometabolic and renal diseases is also explored, and knowledge gaps are highlighted. CNDP2 appears to be a complex participant in human physiological processes and disease, necessitating additional research to unveil its functions and potential therapeutic applications.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142347439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemodynamic Analysis in Aortic Dilatation after Arterial Switch Operation for Patients with Transposition of Great Arteries Using Computational Fluid Dynamics. 利用计算流体力学分析大动脉错位患者动脉转换手术后主动脉扩张的血流动力学。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-09-25 DOI: 10.1007/s12265-024-10562-2

Woo Young Park, Sang Yun Lee, Jongmin Seo

{"title":"Hemodynamic Analysis in Aortic Dilatation after Arterial Switch Operation for Patients with Transposition of Great Arteries Using Computational Fluid Dynamics.","authors":"Woo Young Park, Sang Yun Lee, Jongmin Seo","doi":"10.1007/s12265-024-10562-2","DOIUrl":"https://doi.org/10.1007/s12265-024-10562-2","url":null,"abstract":"After an arterial switch operation for complete transposition of the great arteries, neo-aortic root dilatation occurs, with unclear hemodynamic effects. This study analyzes three groups (severe dilation, mild dilation, and normal) using computational fluid dynamics (CFD) on cardiac CT scans. Aortic arch angles in severe (median 72.3, range: 68.5-77.2) and mild dilation (76.6, 71.1-85.2) groups are significantly smaller than the normal group (97.3, 87.4-99.0). In the normal and mild dilatation groups, Wall Shear Stress (WSS) exhibits a consistent pattern: it is lowest at the aortic root, gradually increases until just before the bend in the aortic arch, peaks, and then subsequently decreases. However, severe dilation shows disrupted WSS patterns, notably lower in the distal ascending aorta, attributed to local recirculation. This unique WSS pattern observed in severely dilated patients, especially in the transverse aorta. CFD plays an essential role in comprehensively studying the pathophysiology underlying aortic dilation in this population.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142347440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leukocyte Extracellular Vesicles Predict Progression of Systolic Dysfunction in Heart Failure with Mildly Reduced Ejection Fraction (LYCHEE) - A Prospective, Multicentre Cohort Study. 白细胞胞外小泡预测射血分数轻度降低的心力衰竭患者收缩功能障碍的进展（LYCHEE）--一项前瞻性多中心队列研究。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-09-24 DOI: 10.1007/s12265-024-10561-3

Aleksandra Gąsecka, Aleksander Siniarski, Piotr Duchnowski, Konrad Stępień, Ewelina Błażejowska, Magdalena Gajewska, Kacper Karaban, Kinga Porębska, Aleksandra Reda, Sylwester Rogula, Bartosz Rolek, Dorota Słupik, Roksana Gozdowska, Marcin Kleibert, Dominika Zajkowska, Michał Grąt, Marcin Grabowski, Krzysztof J Filipiak, Edwin van der Pol, Rienk Nieuwland

{"title":"Leukocyte Extracellular Vesicles Predict Progression of Systolic Dysfunction in Heart Failure with Mildly Reduced Ejection Fraction (LYCHEE) - A Prospective, Multicentre Cohort Study.","authors":"Aleksandra Gąsecka, Aleksander Siniarski, Piotr Duchnowski, Konrad Stępień, Ewelina Błażejowska, Magdalena Gajewska, Kacper Karaban, Kinga Porębska, Aleksandra Reda, Sylwester Rogula, Bartosz Rolek, Dorota Słupik, Roksana Gozdowska, Marcin Kleibert, Dominika Zajkowska, Michał Grąt, Marcin Grabowski, Krzysztof J Filipiak, Edwin van der Pol, Rienk Nieuwland","doi":"10.1007/s12265-024-10561-3","DOIUrl":"https://doi.org/10.1007/s12265-024-10561-3","url":null,"abstract":"Risk stratification in heart failure with mildly-reduced ejection fraction (HFmrEF) remains challenging. We evaluated the predictive value of advanced glycation end products (AGEs) and plasma concentrations of extracellular vesicles (EVs) for the systolic and diastolic dysfunction progression in HFmrEF patients. Skin AGE accumulation was measured using AGE Reader. Plasma EV concentrations were measured using flow cytometry. Among 74 patients enrolled, 13 (18%) had systolic dysfunction progression and 5 (7%) had diastolic dysfunction progression during 6.5 months follow-up. Leukocyte EVs concentrations were higher in patients with systolic dysfunction progression (p = 0.002) and predicted the progression with 75.0% sensitivity and 58.3% specificity, independent of other clinical variables (OR 4.72, 95% CI 0.99-22.31). Skin AGE levels and concentrations of other EV subtypes were not associated with systolic or diastolic dysfunction progression. Increased leukocyte EVs concentrations are associated with 4.7-fold higher odds of systolic dysfunction progression in HFmrEF patients.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dysfunctional HDL Diagnostic Metrics for Cardiovascular Disease Risk Stratification: Are we Ready to Implement in Clinics? 用于心血管疾病风险分层的高密度脂蛋白功能障碍诊断指标：我们准备好在临床中实施了吗？

IF 3.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-09-19 DOI: 10.1007/s12265-024-10559-x

Swetha N. Kempegowda, Kavya Sugur, Rajesh K. Thimmulappa

{"title":"Dysfunctional HDL Diagnostic Metrics for Cardiovascular Disease Risk Stratification: Are we Ready to Implement in Clinics?","authors":"Swetha N. Kempegowda, Kavya Sugur, Rajesh K. Thimmulappa","doi":"10.1007/s12265-024-10559-x","DOIUrl":"https://doi.org/10.1007/s12265-024-10559-x","url":null,"abstract":"Epidemiological studies have revealed that patients with higher levels of high-density lipoprotein cholesterol (HDL-C) were more resistant to cardiovascular diseases (CVD), and yet targeting HDL for CVD prevention, risk assessment, and pharmacological management has not proven to be very effective. The mechanistic investigations have demonstrated that HDL exerts anti-atherogenic functions via mediating reverse cholesterol transport, antioxidant action, anti-inflammatory activity, and anti-thrombotic activity. Contrary to expectations, however, adverse cardiovascular events were reported in clinical trials of drugs that raised HDL levels. This has sparked a debate between HDL quantity and quality. Patients with atherosclerotic CVD are associated with dysfunctional HDL, and the degree of HDL dysfunction is correlated with the severity of the disease, independent of HDL-C levels. This growing body of evidence has underscored the need for integrating HDL functional assays in clinical practice for CVD risk management. Because HDL exerts diverse athero-protective functions, there is no single method for capturing HDL functionality. This review critically evaluates the various techniques currently being used for monitoring HDL functionality and discusses key structural changes in HDL indicative of dysfunctional HDL and the technical challenges that need to be addressed to enable the integration of HDL function-based metrics in clinical practice for CVD risk estimation and the development of newer therapies targeting HDL function.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142254167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of CMR Feature-Tracking Age- and Sex-Dependent Right Ventricular Strain in a Healthy Caucasian Cohort 评估健康白种人队列中与年龄和性别相关的右心室应变的 CMR 特征追踪

IF 3.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-09-18 DOI: 10.1007/s12265-024-10557-z

Jan Eckstein, Hermann Körperich, Oliver M. Weber, Wolfgang Burchert, Volodymyr Pugachov, Oleksandra Demydiuk, Misagh Piran

{"title":"Assessment of CMR Feature-Tracking Age- and Sex-Dependent Right Ventricular Strain in a Healthy Caucasian Cohort","authors":"Jan Eckstein, Hermann Körperich, Oliver M. Weber, Wolfgang Burchert, Volodymyr Pugachov, Oleksandra Demydiuk, Misagh Piran","doi":"10.1007/s12265-024-10557-z","DOIUrl":"https://doi.org/10.1007/s12265-024-10557-z","url":null,"abstract":"Right ventricular (RV) strain offers crucial diagnostic insights in cardiovascular and pulmonary disorders. Nonetheless, the absence of established reference values impedes its clinical implementation. Utilizing CMR-feature tracking, age- and gender-dependent RV strains were systematically assessed in 175 heart-healthy Caucasians, 97 females, median 32.5 years. RV global longitudinal strain (GLS) was greater in females than males (median -26.8% (-28.3;-24.1) vs. -24.4 ± 3.0%; p < 0.001), whereby radial and circumferential strain remained comparable. Age subgroups exhibited increased RV-GLS for group B (30–50 years) (-26.0 ± 3.1% vs. -24.4 ± 3.2%; p = 0.011) and group C (> 50 years) (-26.7 ± 2.3% vs. -24.4 ± 3.2%; p < 0.001) compared to group A (< 30 years). High intra-class correlation coefficients (ICC) were exhibited by intrarater variability (ICC = 0.86–0.95) and moderate levels for interrater variability (ICC = 0.50–0.73). CMR-feature tracking provides a fair quantification method of age- and gender-specific normal RV strain values, demonstrating that higher RV-GLS is linked to female gender and advancing age within a healthy Caucasian cohort.<h3 data-test=\"abstract-sub-heading\">Graphical Abstract</h3>Right-ventricular global longitudinal strain, assessed by cardiac MRI feature-tracking, increases with the female sex and advancing age within a Caucasian cohort of healthy subjects (N = 175)","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142254168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pearls and Pitfalls of Epicardial Echocardiography for Implantation of Impella CP Devices in Ovine Models 在雌鼠模型中植入 Impella CP 设备时进行心外膜超声心动图检查的要点和误区

IF 3.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-09-10 DOI: 10.1007/s12265-024-10555-1

Konstantin Yastrebov, Laurencie M. Brunel, Fiona C. Schnitzler, Lisa M. Partel, Hugh S. Paterson, Paul G. Bannon

{"title":"Pearls and Pitfalls of Epicardial Echocardiography for Implantation of Impella CP Devices in Ovine Models","authors":"Konstantin Yastrebov, Laurencie M. Brunel, Fiona C. Schnitzler, Lisa M. Partel, Hugh S. Paterson, Paul G. Bannon","doi":"10.1007/s12265-024-10555-1","DOIUrl":"https://doi.org/10.1007/s12265-024-10555-1","url":null,"abstract":"The Impella CP is a percutaneously inserted temporary left ventricular assist device used in clinical practice and in translational research into cardiogenic shock, perioperative cardiac surgery, acute cardiac failure and mechanical circulatory support. Fluoroscopic guidance is usually used for insertion of an Impella, thus limiting insertion to within catheterization laboratories. Transthoracic, transoesophageal and intracardiac echocardiography have been reported to guide Impella CP implantation with identified specific limitations stemming from the surgical, anatomical and equipment factors. We conducted translational prospective descriptive feasibility investigation as a part of two other hemodynamic Impella studies. It showed the successful application of epicardial echocardiographic scanning for implantation of Impella CP devices in ovine models, from which details of the technique and identified pitfalls are described with practical solutions for future investigators and clinicians. Many described findings are relevant to any other echocardiographic techniques when adequate imaging of the Impella and relevant anatomical structures is achievable.<h3 data-test=\"abstract-sub-heading\">Graphical Abstract</h3>\u0000","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142226157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AIM2 Deficiency Alleviates Cardiac Inflammation and Hypertrophy in HFD/STZ-Induced Diabetic Mice by Inhibiting the NLRC4/IRF1 Signaling Pathway. 通过抑制 NLRC4/IRF1 信号通路，缺失 AIM2 可减轻高纤维脂肪饮食/STZ 诱导的糖尿病小鼠的心脏炎症和肥大。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-09-04 DOI: 10.1007/s12265-024-10556-0

Jian-Ping Wu, Cheng Wu, Yuan-Ji Ma, Jian-Bing Zhu, Lei-Lei Ma, Fei-Juan Kong

{"title":"AIM2 Deficiency Alleviates Cardiac Inflammation and Hypertrophy in HFD/STZ-Induced Diabetic Mice by Inhibiting the NLRC4/IRF1 Signaling Pathway.","authors":"Jian-Ping Wu, Cheng Wu, Yuan-Ji Ma, Jian-Bing Zhu, Lei-Lei Ma, Fei-Juan Kong","doi":"10.1007/s12265-024-10556-0","DOIUrl":"https://doi.org/10.1007/s12265-024-10556-0","url":null,"abstract":"Absent in melanoma 2(AIM2) exacerbates atherosclerosis by inflammasome assembly. However, AIM2-mediated inflammation in diabetic cardiomyopathy remains incompletely understood. Here we investigate the role of AIM2 in high glucose (HG)- and diabetes-induced inflammatory cardiomyopathy. By RNA-seq, we found that AIM2 were significantly upregulated in HG-induced macrophages, upregulation of AIM2 in cardiac infiltrating macrophages was confirmed in a high-fat diet (HFD)/streptozotocin (STZ)-induceddiabetic mouse model . Therefore, AIM2 knockout mice were constructed. Compared to WT mice, HFD/STZ-induced cardiac hypertrophy and dysfunction were significantly improved in AIM2-/- mice, despite no changes in blood glucose and body weight. Further, AIM2 deficiency inhibited cardiac recruitment of M1-macrophages and cytokine production. Mechanistically, AIM2-deficient macrophgaes reduced IL-1β and TNF-α secretion, which impaired the NLRC4/IRF1 signaling in cardiomyocytes, and reduced further recruitment of macrophages, attenuated cardiac inflammation and hypertrophy, these effects were confirmed by silencing IRF1 in WT mice, and significantly reversed by overexpression of IRF1 in AIM2-/- mice. Taken together, our findings suggest that AIM2 serves as a novel target for the treatment of diabetic cardiomyopathy.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Updated Comprehensive Review of Existing Transcatheter Aortic Valve Replacement Access. 对现有经导管主动脉瓣置换术通路的最新全面回顾。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-08-26 DOI: 10.1007/s12265-024-10484-z

Wenjing Sheng, Hanyi Dai, Rongrong Zheng, Ailifeire Aihemaiti, Xianbao Liu

引用次数: 0

Adult Cardiomyocyte-Derived Extracellular Vesicles: a Promising Therapy for Cardiac Fibrosis. 成人心肌细胞衍生的细胞外囊泡：一种治疗心脏纤维化的有效疗法

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-08-26 DOI: 10.1007/s12265-024-10554-2

Hongyun Wang, Xinpeng Li, Qianwen Wu, Wei Chen, Yihua Bei

引用次数: 0

Intrapericardial Administration to Achieve Localized and Targeted Treatment for Cardiac Disease. 心包内给药，实现心脏疾病的局部靶向治疗。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-08-20 DOI: 10.1007/s12265-024-10553-3

Yaping Xu, Yan Chen, Jun Jie Tan, Jer Ping Ooi, Zhikun Guo

{"title":"Intrapericardial Administration to Achieve Localized and Targeted Treatment for Cardiac Disease.","authors":"Yaping Xu, Yan Chen, Jun Jie Tan, Jer Ping Ooi, Zhikun Guo","doi":"10.1007/s12265-024-10553-3","DOIUrl":"https://doi.org/10.1007/s12265-024-10553-3","url":null,"abstract":"Intrapericardial administration has been proposed as an alternative delivery route of pharmacological agents via the bilaminar sac of pericardium surrounding the heart. To date, intrapericardial administration has entailed the localized administration of a broad spectrum of therapeutic agents. These agents include stem cells, extracellular matrix, growth factor, drugs, bioactive materials, and genetic materials, to the heart and coronary arteries. The route not only overcomes the limitations associated with traditional systemic administration methods, but also presents multiple intrinsic advantages over the other approaches, allowing greater therapeutic actions. Intrapericardial administration exhibits versatility in addressing certain cardiac conditions and ongoing research in this field certainly holds promise for further innovations and advancements to improve cardiac treatment. Thus, this review discusses the anatomy and physiology of the pericardium, the intrapericardial administration access routes, the recent application of intrapericardial delivery in the context of cardiac repair as well as the challenges associated with the approach.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0