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Journal of Cardiovascular Translational Research最新文献

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Apelin13 Loaded Nano-Niosomes Confer Cardioprotection in a Rat Model of Myocardial Ischemia Reperfusion by Targeting the Nrf2/HO-1 Pathway.
IF 2.4 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2025-02-19 DOI: 10.1007/s12265-025-10597-z
Neda Tekiyeh Maroof, Saeed Mehrzadi, Maryam Naseroleslami, Nahid Aboutaleb
{"title":"Apelin13 Loaded Nano-Niosomes Confer Cardioprotection in a Rat Model of Myocardial Ischemia Reperfusion by Targeting the Nrf2/HO-1 Pathway.","authors":"Neda Tekiyeh Maroof, Saeed Mehrzadi, Maryam Naseroleslami, Nahid Aboutaleb","doi":"10.1007/s12265-025-10597-z","DOIUrl":"https://doi.org/10.1007/s12265-025-10597-z","url":null,"abstract":"<p><p>Although apelin-13 has cardioprotective impact, its short half-life in the bloodstream has challenged its clinical application. Using nanocarriers can increase the bioavailability, functionality, and stability of drugs. Current investigation aims to find whether apelin13-loaded nano-niosomes confer cardioprotection in an animal model of myocardial ischemia/reperfusion injury (MI/R) via suppressing ferroptosis, targeting Nrf2 pathway, and AMPK/GSK-3β axis. Ligation of the left anterior coronary artery descending was done to establish the MI/R model and 15 μg/kg of apelin13-loaded nano-niosomes were intramyocardially administrated. Echocardiography, RT-PCR, immunohistochemistry, western blot, ELISA kits, and H&E staining were applied to measure the related indicators. Treatment with both apelin13 and apelin13 loaded nano-niosomes could improve cardiac function and attenuate oxidative stress, myocardial inflammatory factors, and hence ferroptosis by activating the Nrf2 and its downstream proteins HO1, NQO1, AMPK/GSK-3β signaling pathway. In conclusion, apelin13-loaded nano-niosomes are effective MI therapeutic agents against MI/R-induced ferroptosis by activation of Nrf2 via AMPK/GSK-3β axis.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sensitivity of Left Atrial Flow Dynamics to Echocardiographic and Computed Tomography Data.
IF 2.4 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2025-02-19 DOI: 10.1007/s12265-025-10598-y
Ahmad Bshennaty, Brennan J Vogl, Ghasaq Saleh, Agata Sularz, Mohamad Alkhouli, Hoda Hatoum
{"title":"Sensitivity of Left Atrial Flow Dynamics to Echocardiographic and Computed Tomography Data.","authors":"Ahmad Bshennaty, Brennan J Vogl, Ghasaq Saleh, Agata Sularz, Mohamad Alkhouli, Hoda Hatoum","doi":"10.1007/s12265-025-10598-y","DOIUrl":"https://doi.org/10.1007/s12265-025-10598-y","url":null,"abstract":"<p><p>Computational simulations are a powerful tool in the understanding, diagnosing, and treatment of cardiovascular diseases. Incomplete clinical data often limits computational assessment, which may lead to inaccuracies. This study aims to assess the sensitivity of left atrial flow dynamics to echocardiographic and computed tomography data. Models of the LA were reconstructed at the E-wave(Geometry 1)and end-diastolic(Geometry 2)phases from CT scans. CFD simulations were carried out using 3 different sets of BCs. BC2 and BC3 presented similar results that were significantly different from BC1. The effect from the choice of geometry was significant with BC2 and BC3 but minor with BC1. Differences in parameters across the simulated cases highlight the importance of using consistent BCs and geometries for CFD studies. Acquiring the pressure in the LA does not seem to be necessary for the accuracy of CFD simulations. Validation of all simulations indicates reliable patient-specific results.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resonance Raman Spectroscopy Detects Ischemia in Experimental Coarctation of the Aorta in a Rodent Model.
IF 2.4 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2025-02-19 DOI: 10.1007/s12265-025-10599-x
Alyssa R Thomas, Kristen Lazelle, Julia Garcia Mancebo, Padraic Romfh, John N Kheir
{"title":"Resonance Raman Spectroscopy Detects Ischemia in Experimental Coarctation of the Aorta in a Rodent Model.","authors":"Alyssa R Thomas, Kristen Lazelle, Julia Garcia Mancebo, Padraic Romfh, John N Kheir","doi":"10.1007/s12265-025-10599-x","DOIUrl":"https://doi.org/10.1007/s12265-025-10599-x","url":null,"abstract":"<p><p>Coarctation of the aorta (CoA) can cause aortic obstruction, ischemia, and death. Resonance Raman Spectroscopy (RRS) measures tissue oxyhemoglobin (ShbO<sub>2</sub>) and mitochondrial redox state (3RMR) non-invasively. Metal wire was placed around the aorta of Sprague Dawley rats to generate a systolic blood pressure (SBP) gradient. RRS-ShbO<sub>2</sub> and 3RMR were measured pre- (hand) and post-obstruction (foot). In model 1 (n = 8), the gradient rapidly reached 120 mmHg. In model 2 (n = 30), gradients of 20 mmHg (n = 9) and 40 mmHg (n = 12) were maintained for 2 h. In model 1, foot-ShbO<sub>2</sub> and 3RMR changed significantly (P = 0.004 and P = 0.007) at SBP gradients of 80-mmHg or above. In model 2, the 40-mmHg gradient group showed significant declines in foot-ShbO2 (P = 0.014) and increases in 3RMR (P = 0.008) by 1 h. Foot-ShbO<sub>2</sub> and 3RMR correlated strongly with serum mixed venous saturation (ShbO<sub>2</sub>: r = 0.73, P < 0.0001; 3RMR: r = -0.55, P < 0.0001). RRS effectively detects ischemia caused by aortic obstruction in a CoA model.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting Lactic Acid Modification in Ischemic Heart Diseases: Novel Therapeutics and Mechanism.
IF 2.4 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2025-02-07 DOI: 10.1007/s12265-025-10593-3
Tangjiang Wan, Yucheng Liang, Tianwen Wei, Zijie Chen, Yafei Li
{"title":"Targeting Lactic Acid Modification in Ischemic Heart Diseases: Novel Therapeutics and Mechanism.","authors":"Tangjiang Wan, Yucheng Liang, Tianwen Wei, Zijie Chen, Yafei Li","doi":"10.1007/s12265-025-10593-3","DOIUrl":"https://doi.org/10.1007/s12265-025-10593-3","url":null,"abstract":"<p><p>Ischemic heart disease (IHD), especially acute myocardial infarction (AMI), has a high mortality rate and poses a great threat to human health. When myocardial infarction occurs, the structure and function of the myocardium are significantly damaged, and its metabolisms switch from oxidative phosphorylation to glycolysis, producing lactate. Lactylation, as a newly discovered post-translational modification (PMT) in recent years, is involved in the regulation of gene expression, and cell proliferation. Emerging studies have revealed that lactate and lactylation modifications participate in inflammation and cardiac repair, and play an important role in cardiovascular diseases, such as myocardial infarction, myocardial fibrosis, and heart failure. Therefore, in this review, we discuss how glucose metabolism, glycolytic end-product lactate, and lactylation potentially interact with pathological processes, including inflammation, cardiac fibrosis, and heart failure. And targeting glycolysis and lactylation modification could provide a promising future for cardiovascular diseases.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting KDM4C Prevents Heart Failure after Acute Myocardial Infarction Via Activation of SOS2.
IF 2.4 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2025-02-03 DOI: 10.1007/s12265-025-10594-2
Caiping Tan, Xiaoqi Chen, Lingqi Xu, Jiaping Chen, Yingbing Tu
{"title":"Targeting KDM4C Prevents Heart Failure after Acute Myocardial Infarction Via Activation of SOS2.","authors":"Caiping Tan, Xiaoqi Chen, Lingqi Xu, Jiaping Chen, Yingbing Tu","doi":"10.1007/s12265-025-10594-2","DOIUrl":"https://doi.org/10.1007/s12265-025-10594-2","url":null,"abstract":"<p><p>Here, we focused on the function of SOS2 in heart failure (HF) after acute myocardial infarction (AMI) and investigated the mechanism. An oxygen-glucose deprivation (OGD) model in HL-1 cardiomyocytes and the ligation of the left anterior descending coronary artery in mice were conducted for MI modeling. SOS2 was downregulated in the heart tissues of mice with AMI. SOS2 activated the PI3K/Akt signaling, thereby alleviating cardiomyocyte apoptosis and inflammatory response, which were compromised by PI3K/Akt signaling inhibitor LY294002. Lysine-specific demethylase 4C (KDM4C) levels were downregulated in the heart tissue of AMI mice and OGD-induced HL-1 cells, accompanied by a reduction in H3K9Me3, while KDM4C overexpression triggered SOS2 expression by removing H3K9Me3 modification from its promoter. Knockdown of SOS2 abated the effects of KDM4C overexpression, thereby accentuating HF in mice. This study revealed that KDM4C protected mice against HF following AMI by restoration of SOS2 and the PI3K/Akt signaling.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lymphatic Drainage in Patients with Heart Failure: A Feasibility Study.
IF 2.4 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2025-02-03 DOI: 10.1007/s12265-025-10592-4
Husam M Salah, Adrian Ebner, Ravi N Srinivasa, Waleska Pabon-Ramos, Jeffrey Forris Beecham Chick, Jan Biegus, Piotr Ponikowski, Abubaker Khalifa, Marat Fudim
{"title":"Lymphatic Drainage in Patients with Heart Failure: A Feasibility Study.","authors":"Husam M Salah, Adrian Ebner, Ravi N Srinivasa, Waleska Pabon-Ramos, Jeffrey Forris Beecham Chick, Jan Biegus, Piotr Ponikowski, Abubaker Khalifa, Marat Fudim","doi":"10.1007/s12265-025-10592-4","DOIUrl":"https://doi.org/10.1007/s12265-025-10592-4","url":null,"abstract":"<p><p>Lymphatic dysfunction contributes to congestion and end-organ damage in heart failure (HF), yet current therapies do not directly target lymphatic congestion. Thoracic duct (TD) drainage offers a novel approach to address this gap. This multicenter feasibility study evaluated the safety and feasibility of minimally invasive TD drainage in patients with HF. Four patients with New York Heart Association class II-IV HF and fluid overload underwent fluoroscopy-guided TD access via cervical, abdominal, or transvenous brachial approaches. Lymph was drained by gravity for up to 3 hours, and hemodynamic changes were measured. TD drainage was successful in all patients, with a mean lymph output of 430 mL. Mean reductions in right atrial and pulmonary capillary wedge pressures were 4 mmHg and 1.5 mmHg, respectively. No major adverse events occurred. TD drainage appears feasible and safe, with potential decongestive benefits. Larger studies are needed to confirm its role in HF management.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The link between ferroptosis and autophagy in myocardial ischemia/reperfusion injury: new directions for therapy.
IF 2.4 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2025-01-30 DOI: 10.1007/s12265-025-10590-6
Xiaoting Yang, Hui Wu, Di Liu, Gang Zhou, Dong Zhang, Qingzhuo Yang, Yanfang Liu, Yi Li
{"title":"The link between ferroptosis and autophagy in myocardial ischemia/reperfusion injury: new directions for therapy.","authors":"Xiaoting Yang, Hui Wu, Di Liu, Gang Zhou, Dong Zhang, Qingzhuo Yang, Yanfang Liu, Yi Li","doi":"10.1007/s12265-025-10590-6","DOIUrl":"https://doi.org/10.1007/s12265-025-10590-6","url":null,"abstract":"<p><p>Myocardial ischemia/reperfusion (I/R)-induced cell death, such as autophagy and ferroptosis, is a major contributor to cardiac injury. Regulating cell death may be key to mitigating myocardial ischemia/reperfusion injury (MI/RI). Autophagy is a crucial physiological process involving cellular self-digestion and compensation, responsible for degrading excess or malfunctioning long-lived proteins and organelles. During MI/RI, autophagy plays both \"survival\" and \"death\" roles. A growing body of research indicates that ferroptosis is a type of autophagy-dependent cell death. This article provides a comprehensive review of the functions of autophagy and ferroptosis in MI/RI, as well as the molecules mediating their interaction. Understanding the link between autophagy and ferroptosis may offer new therapeutic directions for MI/RI, bearing significant clinical implications.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Best Paper of the Year 2024.
IF 2.4 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2025-01-29 DOI: 10.1007/s12265-025-10595-1
Rupak Mukherjee, Enrique Lara-Pezzi
{"title":"Best Paper of the Year 2024.","authors":"Rupak Mukherjee, Enrique Lara-Pezzi","doi":"10.1007/s12265-025-10595-1","DOIUrl":"https://doi.org/10.1007/s12265-025-10595-1","url":null,"abstract":"","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial Dysfunction in HFpEF: Potential Interventions Through Exercise. 高频心衰的线粒体功能障碍：通过运动进行潜在干预
IF 2.4 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2025-01-25 DOI: 10.1007/s12265-025-10591-5
Xinxin Cui, Michail Spanos, Cuimei Zhao, Wensi Wan, Caiyue Cui, Lijun Wang, Junjie Xiao
{"title":"Mitochondrial Dysfunction in HFpEF: Potential Interventions Through Exercise.","authors":"Xinxin Cui, Michail Spanos, Cuimei Zhao, Wensi Wan, Caiyue Cui, Lijun Wang, Junjie Xiao","doi":"10.1007/s12265-025-10591-5","DOIUrl":"https://doi.org/10.1007/s12265-025-10591-5","url":null,"abstract":"<p><p>HFpEF is a prevalent and complex type of heart failure. The concurrent presence of conditions such as obesity, hypertension, hyperglycemia, and hyperlipidemia significantly increase the risk of developing HFpEF. Mitochondria, often referred to as the powerhouses of the cell, are crucial in maintaining cellular functions, including ATP production, intracellular Ca<sup>2+</sup> regulation, reactive oxygen species generation and clearance, and the regulation of apoptosis. Exercise plays a vital role in preserving mitochondrial homeostasis, thereby protecting the cardiovascular system from acute stress, and is a fundamental component in maintaining cardiovascular health. In this study, we review the mitochondrial dysfunction underlying the development and progression of HFpEF. Given the pivotal role of exercise in modulating cardiovascular diseases, we particularly focus on exercise as a potential therapeutic strategy for improving mitochondrial function. Graphical abstract Note: This picture was created with BioRender.com.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Class III Phosphatidylinositol-3 Kinase/Vacuolar Protein Sorting 34 in Cardiovascular Health and Disease. ⅲ类磷脂酰肌醇-3激酶/液泡蛋白分选34在心血管健康和疾病中的作用。
IF 2.4 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2025-01-16 DOI: 10.1007/s12265-024-10581-z
Yuanjun Shen, Jason P Gleghorn
{"title":"Class III Phosphatidylinositol-3 Kinase/Vacuolar Protein Sorting 34 in Cardiovascular Health and Disease.","authors":"Yuanjun Shen, Jason P Gleghorn","doi":"10.1007/s12265-024-10581-z","DOIUrl":"https://doi.org/10.1007/s12265-024-10581-z","url":null,"abstract":"<p><p>Phosphatidylinositol-3 kinases (PI3Ks) play a critical role in maintaining cardiovascular health and the development of cardiovascular diseases (CVDs). Specifically, vacuolar Protein Sorting 34 (VPS34) or PIK3C3, the only member of Class III PI3K, plays an important role in CVD progression. The main function of VPS34 is inducing the production of phosphatidylinositol 3-phosphate, which, together with other essential structural and regulatory proteins in forming VPS34 complexes, further regulates the mammalian target of rapamycin activation, autophagy, and endocytosis. VPS34 is found to have crucial functions in the cardiovascular system, including dictating the proliferation and survival of vascular smooth muscle cells and cardiomyocytes and the formation of thrombosis. This review aims to summarize our current knowledge and recent advances in understanding the function and regulation of VPS34 in cardiovascular health and disease. We also discuss the current development of VPS34 inhibitors and their potential to treat CVDs.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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