Journal of Cardiovascular Translational Research最新文献

Mitochondrial Dysfunction in HFpEF: Potential Interventions Through Exercise. 高频心衰的线粒体功能障碍：通过运动进行潜在干预

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-01-25 DOI: 10.1007/s12265-025-10591-5

Xinxin Cui, Michail Spanos, Cuimei Zhao, Wensi Wan, Caiyue Cui, Lijun Wang, Junjie Xiao

引用次数: 0

Class III Phosphatidylinositol-3 Kinase/Vacuolar Protein Sorting 34 in Cardiovascular Health and Disease. ⅲ类磷脂酰肌醇-3激酶/液泡蛋白分选34在心血管健康和疾病中的作用。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-01-16 DOI: 10.1007/s12265-024-10581-z

Yuanjun Shen, Jason P Gleghorn

引用次数: 0

Chitinase-3-like Protein 1 Reduces the Stability of Atherosclerotic Plaque via Impairing Macrophagic Efferocytosis. 几丁质酶-3样蛋白1通过损害巨噬细胞Efferocytosis降低动脉粥样硬化斑块的稳定性。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-01-15 DOI: 10.1007/s12265-024-10576-w

Yandong Liu, Weilin Hu, Futang Yang, Sili Zou, Huiqiong Ren, Yong Zuo, Lefeng Qu

{"title":"Chitinase-3-like Protein 1 Reduces the Stability of Atherosclerotic Plaque via Impairing Macrophagic Efferocytosis.","authors":"Yandong Liu, Weilin Hu, Futang Yang, Sili Zou, Huiqiong Ren, Yong Zuo, Lefeng Qu","doi":"10.1007/s12265-024-10576-w","DOIUrl":"https://doi.org/10.1007/s12265-024-10576-w","url":null,"abstract":"CHI3L1 is strongly associated with atherosclerosis, but its role in macrophages remains unknown. In this study, we observed a significant up-regulation of CHI3L1 in both carotid plaques and serum of symptomatic patients, and demonstrated that CHI3L1 impairs the efferocytosis of macrophages by down-regulating crucial efferocytic mediator MFGE8 through inhibiting ATF2, which binds directly to the enhancer of MFGE8. In human plaques, we observed a negative correlation between CHI3L1 expression and both ATF2 and MFGE8 levels, further proved their involvement in plaque destabilization. Using Ldlr-/- mice with tandem carotid stenosis surgery, we demonstrated that administration of CHI3L1 protein resulted in enlarged atherosclerotic necrotic cores and decreased MFGE8 and ATF2 levels. Conversely, treatment with a CHI3L1 blocking antibody exhibited the opposite trend.In conclusion, CHI3L1 destabilizes atherosclerotic plaque by impairing macrophagic efferocytosis through the down-regulation of ATF2-induced MFGE8 expression. Targeting CHI3L1 may offer a promising therapeutic strategy for the treatment of atherosclerosis.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

p16^INK4a Aggravated Sepsis-associated Cardiac Injury by Inhibiting the PI3K/AKT Pathway and Inducing Redox Imbalance. p16INK4a通过抑制PI3K/AKT通路和诱导氧化还原失衡加重败血症相关的心脏损伤。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-01-14 DOI: 10.1007/s12265-024-10588-6

Baihong Li, Kai Wang, Xiaoyan Wang, Zhixuan Zhang, Guangyi Huang, Yiyi Ma, Yingqiang Du, Xin Gu, Jie Hui

引用次数: 0

CRISPR-Cas9 Targeting PCSK9: A Promising Therapeutic Approach for Atherosclerosis. 靶向PCSK9的CRISPR-Cas9：一种有希望的动脉粥样硬化治疗方法

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-01-13 DOI: 10.1007/s12265-024-10587-7

Bin Gu, Min Li, Dan Li, Kaisen Huang

引用次数: 0

Development and Internal Validation of an AI-Enabled Cuff-less, Non-invasive Continuous Blood Pressure Monitor Across All Classes of Hypertension. 开发并在内部验证人工智能无袖带无创连续血压监测仪，适用于所有类型的高血压。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-01-13 DOI: 10.1007/s12265-024-10589-5

Francisco Lopez-Jimenez, Abhishek Deshmukh, John Bisognano, John Boehmer, Mouli Ramasamy, Prashanth Shyam Kumar, Suraj Kapa, Venk Varadan, Vijay Varadan, Marat Fudim

{"title":"Development and Internal Validation of an AI-Enabled Cuff-less, Non-invasive Continuous Blood Pressure Monitor Across All Classes of Hypertension.","authors":"Francisco Lopez-Jimenez, Abhishek Deshmukh, John Bisognano, John Boehmer, Mouli Ramasamy, Prashanth Shyam Kumar, Suraj Kapa, Venk Varadan, Vijay Varadan, Marat Fudim","doi":"10.1007/s12265-024-10589-5","DOIUrl":"https://doi.org/10.1007/s12265-024-10589-5","url":null,"abstract":"Background: Non-invasive, continuous blood pressure monitoring technologies require additional validation beyond standard cuff-based methods. This study evaluates a non-invasive, multiparametric wearable cuffless blood pressure (BP) diagnostic monitor across all hypertension classes with diverse subjects.Methods: A prospective, multicenter study assessed Nanowear's SimpleSense-BP performance, including induced and natural BP changes, significant BP variations (Systolic BP (SBP) ≥ ± 15 mm Hg and Diastolic BP (DBP) ≥ ± 10 mm Hg), and reference input value validity over 4 weeks.Results: 303 subjects (18-83 yrs; 50.16% Female) participated in algorithmic development and validation (Normal - 35%, Prehypertensive - 24%, Stage 1 - 24%, Stage 2 - 17%). 54 subjects were tested for induced change performance, 149 exhibited significant changes, and 91 validated reference value duration.Conclusions: The study clinically validated a continuous, AI-based BP diagnostic monitor using non-invasive wearable data. Further testing on diverse populations and external validation are recommended. The protocol was inspired by ISO 81060-2 and IEEE 1708:2019 standards.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long Non-Coding RNAs in Diabetic Cardiomyopathy: Potential Function as Biomarkers and Therapeutic Targets of Exercise Training. 长链非编码rna在糖尿病性心肌病中的潜在功能：作为生物标志物和运动训练的治疗靶点。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-01-09 DOI: 10.1007/s12265-024-10586-8

Jie Hu, Xinwen Miao, Li-Hua Yu

{"title":"Long Non-Coding RNAs in Diabetic Cardiomyopathy: Potential Function as Biomarkers and Therapeutic Targets of Exercise Training.","authors":"Jie Hu, Xinwen Miao, Li-Hua Yu","doi":"10.1007/s12265-024-10586-8","DOIUrl":"https://doi.org/10.1007/s12265-024-10586-8","url":null,"abstract":"Recent studies emphasize the beneficial effects of exercise on diabetic cardiomyopathy (DCM), adding to the growing body of evidence that underscores the role of exercise in improving health outcomes. Despite this, a notable gap persists in the number of healthcare providers who actively prescribe exercise as a therapeutic intervention for DCM management. In addition, exercise modulates the expression of lncRNAs, which play a pivotal role in DCM progression. Further investigation into this relationship may facilitate the identification of novel biomarkers and therapeutic targets for DCM. This review consolidates recent advances in identifying lncRNAs biomarkers in DCM, summarizing the current knowledge on dysregulated lncRNAs and their molecular mechanisms. Additionally, it offers new insights into the mechanistic roles of lncRNAs, highlighting their potential as biomarkers and therapeutic targets for DCM. Overall, this review aims to inform future research and reinforce the significance of addressing diabetes-related cardiovascular diseases to potentially improve clinical outcomes.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-01-09 DOI: 10.1007/s12265-024-10583-x

Xing-Jie Wang, Lei Huang, Min Hou, Jie Guo

{"title":"Senescence-related Genes as Prognostic Markers for STEMI Patients: LASSO Regression-Based Bioinformatics and External Validation.","authors":"Xing-Jie Wang, Lei Huang, Min Hou, Jie Guo","doi":"10.1007/s12265-024-10583-x","DOIUrl":"https://doi.org/10.1007/s12265-024-10583-x","url":null,"abstract":"The prognostic value of differentially expressed senescence-related genes(DESRGs) in ST-segment elevation myocardial infarction(STEMI) patients is unclear. We used GEO2R to identify DESRGs from GSE60993 and performed functional enrichment analysis. We built an optimal prognostic model with LASSO penalized Cox regression via GSE49925. We evaluated the model with survival analysis, ROC curve, decision curve analysis, nomogram, and external validation with plasma samples. We created a prognostic signature with three dysregulated DESRGs (CDC25B, FKBP5, and ECHDC3) and two clinical variables (serum creatinine, Gensini score). The signature stratified patients into low- and high-risk groups and showed strong predictive performance within two years. The external validation confirmed the survival difference between the groups. We identified three DESRGs that were differentially expressed and prognostic in STEMI patients. The model incorporating three DESRGs showed promising prediction and utility for stratifying patients and estimating survival risk in STEMI patients.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic Value and Short-Term Prognosis Assessment of Copeptin in Non-ST-Elevation Acute Coronary Syndrome. Copeptin在非st段抬高急性冠脉综合征中的诊断价值及短期预后评价。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-12-28 DOI: 10.1007/s12265-024-10584-w

Facai Cui, Xueliang Pei, Mingzhi Ling, Fengxia Guo

引用次数: 0

Bufalin Ameliorates Myocardial Ischemia/Reperfusion Injury by Suppressing Macrophage Pyroptosis via P62 Pathway. 蟾毒灵通过P62途径抑制巨噬细胞焦亡改善心肌缺血再灌注损伤

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-12-28 DOI: 10.1007/s12265-024-10577-9

Chang Li, Zhen Ma, Xiang Wei, Ying Wang, Jian Wu, Xuan Li, Xiaolei Sun, Zhiwen Ding, Cheng Yang, Yunzeng Zou

{"title":"Bufalin Ameliorates Myocardial Ischemia/Reperfusion Injury by Suppressing Macrophage Pyroptosis via P62 Pathway.","authors":"Chang Li, Zhen Ma, Xiang Wei, Ying Wang, Jian Wu, Xuan Li, Xiaolei Sun, Zhiwen Ding, Cheng Yang, Yunzeng Zou","doi":"10.1007/s12265-024-10577-9","DOIUrl":"https://doi.org/10.1007/s12265-024-10577-9","url":null,"abstract":"Bufalin, which is isolated from toad venom, exerts positive effects on hearts under pathological circumstance. We aimed to investigate the effects and mechanisms of bufalin on myocardial I/R injury. In vivo, bufalin ameliorated myocardial I/R injury, which characteristics with better ejection function, decreased infarct size and less apoptosis. The levels of pyroptotic proteins were increased in I/R-treated macrophages and inflammatory cytokines expressed more in I/R-induced mouse, which could be attenuated by bufalin. Bufalin also reduced H/R-treated macrophage pyroptosis in vitro. Autophagic flux blockage and ROS accumulation were reduced by bufalin in impaired macrophages. Overexpression of p62 abrogated the anti-proptosis and anti-oxidative effects of bufalin. The levels of apoptosis related proteins were changed and TUNEL-positive ratio was raised in cardiomyocytes that received conditioned medium treatment with H/R-treated macrophages, while bufalin pretreatment could reduce apoptosis. These findings indicate that bufalin may attenuate myocardial I/R injury by suppressing macrophage pyroptosis via P62 pathway.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0