Journal of Cardiovascular Translational Research最新文献_第2页

Apelin13 Loaded Nano-Niosomes Confer Cardioprotection in a Rat Model of Myocardial Ischemia Reperfusion by Targeting the Nrf2/HO-1 Pathway.

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-02-19 DOI: 10.1007/s12265-025-10597-z

Neda Tekiyeh Maroof, Saeed Mehrzadi, Maryam Naseroleslami, Nahid Aboutaleb

{"title":"Apelin13 Loaded Nano-Niosomes Confer Cardioprotection in a Rat Model of Myocardial Ischemia Reperfusion by Targeting the Nrf2/HO-1 Pathway.","authors":"Neda Tekiyeh Maroof, Saeed Mehrzadi, Maryam Naseroleslami, Nahid Aboutaleb","doi":"10.1007/s12265-025-10597-z","DOIUrl":"https://doi.org/10.1007/s12265-025-10597-z","url":null,"abstract":"Although apelin-13 has cardioprotective impact, its short half-life in the bloodstream has challenged its clinical application. Using nanocarriers can increase the bioavailability, functionality, and stability of drugs. Current investigation aims to find whether apelin13-loaded nano-niosomes confer cardioprotection in an animal model of myocardial ischemia/reperfusion injury (MI/R) via suppressing ferroptosis, targeting Nrf2 pathway, and AMPK/GSK-3β axis. Ligation of the left anterior coronary artery descending was done to establish the MI/R model and 15 μg/kg of apelin13-loaded nano-niosomes were intramyocardially administrated. Echocardiography, RT-PCR, immunohistochemistry, western blot, ELISA kits, and H&E staining were applied to measure the related indicators. Treatment with both apelin13 and apelin13 loaded nano-niosomes could improve cardiac function and attenuate oxidative stress, myocardial inflammatory factors, and hence ferroptosis by activating the Nrf2 and its downstream proteins HO1, NQO1, AMPK/GSK-3β signaling pathway. In conclusion, apelin13-loaded nano-niosomes are effective MI therapeutic agents against MI/R-induced ferroptosis by activation of Nrf2 via AMPK/GSK-3β axis.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensitivity of Left Atrial Flow Dynamics to Echocardiographic and Computed Tomography Data.

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-02-19 DOI: 10.1007/s12265-025-10598-y

Ahmad Bshennaty, Brennan J Vogl, Ghasaq Saleh, Agata Sularz, Mohamad Alkhouli, Hoda Hatoum

引用次数: 0

Resonance Raman Spectroscopy Detects Ischemia in Experimental Coarctation of the Aorta in a Rodent Model.

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-02-19 DOI: 10.1007/s12265-025-10599-x

Alyssa R Thomas, Kristen Lazelle, Julia Garcia Mancebo, Padraic Romfh, John N Kheir

{"title":"Resonance Raman Spectroscopy Detects Ischemia in Experimental Coarctation of the Aorta in a Rodent Model.","authors":"Alyssa R Thomas, Kristen Lazelle, Julia Garcia Mancebo, Padraic Romfh, John N Kheir","doi":"10.1007/s12265-025-10599-x","DOIUrl":"10.1007/s12265-025-10599-x","url":null,"abstract":"Coarctation of the aorta (CoA) can cause aortic obstruction, ischemia, and death. Resonance Raman Spectroscopy (RRS) measures tissue oxyhemoglobin (ShbO2) and mitochondrial redox state (3RMR) non-invasively. Metal wire was placed around the aorta of Sprague Dawley rats to generate a systolic blood pressure (SBP) gradient. RRS-ShbO2 and 3RMR were measured pre- (hand) and post-obstruction (foot). In model 1 (n = 8), the gradient rapidly reached 120 mmHg. In model 2 (n = 30), gradients of 20 mmHg (n = 9) and 40 mmHg (n = 12) were maintained for 2 h. In model 1, foot-ShbO2 and 3RMR changed significantly (P = 0.004 and P = 0.007) at SBP gradients of 80-mmHg or above. In model 2, the 40-mmHg gradient group showed significant declines in foot-ShbO2 (P = 0.014) and increases in 3RMR (P = 0.008) by 1 h. Foot-ShbO2 and 3RMR correlated strongly with serum mixed venous saturation (ShbO2: r = 0.73, P < 0.0001; 3RMR: r = -0.55, P < 0.0001). RRS effectively detects ischemia caused by aortic obstruction in a CoA model.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting Lactic Acid Modification in Ischemic Heart Diseases: Novel Therapeutics and Mechanism.

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-02-07 DOI: 10.1007/s12265-025-10593-3

Tangjiang Wan, Yucheng Liang, Tianwen Wei, Zijie Chen, Yafei Li

{"title":"Targeting Lactic Acid Modification in Ischemic Heart Diseases: Novel Therapeutics and Mechanism.","authors":"Tangjiang Wan, Yucheng Liang, Tianwen Wei, Zijie Chen, Yafei Li","doi":"10.1007/s12265-025-10593-3","DOIUrl":"https://doi.org/10.1007/s12265-025-10593-3","url":null,"abstract":"Ischemic heart disease (IHD), especially acute myocardial infarction (AMI), has a high mortality rate and poses a great threat to human health. When myocardial infarction occurs, the structure and function of the myocardium are significantly damaged, and its metabolisms switch from oxidative phosphorylation to glycolysis, producing lactate. Lactylation, as a newly discovered post-translational modification (PMT) in recent years, is involved in the regulation of gene expression, and cell proliferation. Emerging studies have revealed that lactate and lactylation modifications participate in inflammation and cardiac repair, and play an important role in cardiovascular diseases, such as myocardial infarction, myocardial fibrosis, and heart failure. Therefore, in this review, we discuss how glucose metabolism, glycolytic end-product lactate, and lactylation potentially interact with pathological processes, including inflammation, cardiac fibrosis, and heart failure. And targeting glycolysis and lactylation modification could provide a promising future for cardiovascular diseases.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting KDM4C Prevents Heart Failure after Acute Myocardial Infarction Via Activation of SOS2.

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-02-03 DOI: 10.1007/s12265-025-10594-2

Caiping Tan, Xiaoqi Chen, Lingqi Xu, Jiaping Chen, Yingbing Tu

引用次数: 0

Lymphatic Drainage in Patients with Heart Failure: A Feasibility Study.

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-02-03 DOI: 10.1007/s12265-025-10592-4

Husam M Salah, Adrian Ebner, Ravi N Srinivasa, Waleska Pabon-Ramos, Jeffrey Forris Beecham Chick, Jan Biegus, Piotr Ponikowski, Abubaker Khalifa, Marat Fudim

引用次数: 0

Past Trends and Future Directions of Cardiac Regenerative Medicine - A Systematic Analysis of Clinical Trial Registries. 心脏再生医学的过去趋势和未来方向--临床试验登记系统分析》。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-02-01 Epub Date: 2024-10-03 DOI: 10.1007/s12265-024-10563-1

Maaike Wulfse, Mats T Vervoorn, Jantijn J G J Amelink, Elisa M Ballan, Saskia C A de Jager, Joost P G Sluijter, Pieter A Doevendans, Peter-Paul M Zwetsloot, Niels P Van der Kaaij

{"title":"Past Trends and Future Directions of Cardiac Regenerative Medicine - A Systematic Analysis of Clinical Trial Registries.","authors":"Maaike Wulfse, Mats T Vervoorn, Jantijn J G J Amelink, Elisa M Ballan, Saskia C A de Jager, Joost P G Sluijter, Pieter A Doevendans, Peter-Paul M Zwetsloot, Niels P Van der Kaaij","doi":"10.1007/s12265-024-10563-1","DOIUrl":"10.1007/s12265-024-10563-1","url":null,"abstract":"Cell therapy, gene therapy, and tissue engineering have been explored as potential strategies to repair or regenerate damaged cardiac tissue. Despite the presence of encouraging preclinical data, clinical trials of regenerative cardiac therapies have yielded mixed results. Our study aimed to investigate the fate of all registered clinical trials within regenerative cardiac medicine, with the purpose of exploring the potential role of publication bias (or trial-completion bias), how published and unpublished research affects the field, and to draw lessons and recommendations for future clinical trials. In this analysis, we show that only a third of all registered trials has yielded results and that a significant number of trials are not completed. Furthermore, we identified significant heterogeneity in study design, study phase, funding, specific therapies used, primary outcome measures and methods of outcome assessment. These observations might hinder the successful translation of cardiac regenerative therapies into clinical practice.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"209-220"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11885401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shorter Leukocyte Telomere Length Is Associated with Increased Major Adverse Cardiovascular Events or Mortality in Patients with Essential Hypertension. 白细胞端粒长度缩短与重度高血压患者主要不良心血管事件或死亡率增加有关。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-02-01 Epub Date: 2024-10-18 DOI: 10.1007/s12265-024-10558-y

Hongna Fu, Yuanting Zhu, Luyang Lin, Peng Jiang, Guoyi Cai, Lijin Zeng, Xinyu Li, Yuchun Zhang, Chunhao Li, Hong Zhan, Bo Zhang, Zhen Yang

{"title":"Shorter Leukocyte Telomere Length Is Associated with Increased Major Adverse Cardiovascular Events or Mortality in Patients with Essential Hypertension.","authors":"Hongna Fu, Yuanting Zhu, Luyang Lin, Peng Jiang, Guoyi Cai, Lijin Zeng, Xinyu Li, Yuchun Zhang, Chunhao Li, Hong Zhan, Bo Zhang, Zhen Yang","doi":"10.1007/s12265-024-10558-y","DOIUrl":"10.1007/s12265-024-10558-y","url":null,"abstract":"The association between leukocyte telomere length (LTL) alteration and major adverse cardiovascular events (MACE) or mortality in patients with hypertension is still unclear. 20,034 patients with essential hypertension were enrolled from UK biobank. Multivariable COX regression models were performed to assess the association. LTL was shorter in hypertensive patients with MACE compared to those without MACE. Hypertensive patients in the lowest LTL quartile were at higher risk to develop MACE (adjusted HR 1.15 [95% CI 1.02-1.29], vs top LTL quartile, p-trend = 0.03). Similarly, shorter LTL was related with increased mortality (adjusted HR 1.18[95% CI 1.06-1.3], lowest vs top LTL quartile, p-trend < 0.001). This investigation demonstrated that shorter LTL is associated with increased risk of MACE or mortality in patients with essential hypertension, which indicates that LTL may be a potential predictor of prognosis or underlying therapeutic target for hypertension.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"198-208"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Outcome of Hypertrophic Cardiomyopathy in Probands with the Founder Variant c.913_914del in MYBPC3: A Slovenian Cohort Study. 具有 MYBPC3 基因 c.913_914del 父系变异的肥厚型心肌病患者的临床预后：一项斯洛文尼亚队列研究。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-02-01 Epub Date: 2024-08-19 DOI: 10.1007/s12265-024-10551-5

Nina Vodnjov, Aleš Maver, Nataša Teran, Borut Peterlin, Janez Toplišek, Karin Writzl

引用次数: 0

H-FABP as a Biomarker in Transient Ischemic Attack. 作为短暂性脑缺血发作生物标志物的 H-FABP

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-02-01 Epub Date: 2024-08-19 DOI: 10.1007/s12265-024-10552-4

Daisy Guamán-Pilco, Elvira Chocano, Elena Palà, Marcel Lamana-Vallverdú, Anna Penalba, Paula García-Rodríguez, Marta Rubiera, Alejandro Bustamante, Àlex Rovira, Soledad Pérez-Sánchez, Leire Azurmendi, Sandrine Reymond, Jean-Charles Sánchez, Joan Montaner

{"title":"H-FABP as a Biomarker in Transient Ischemic Attack.","authors":"Daisy Guamán-Pilco, Elvira Chocano, Elena Palà, Marcel Lamana-Vallverdú, Anna Penalba, Paula García-Rodríguez, Marta Rubiera, Alejandro Bustamante, Àlex Rovira, Soledad Pérez-Sánchez, Leire Azurmendi, Sandrine Reymond, Jean-Charles Sánchez, Joan Montaner","doi":"10.1007/s12265-024-10552-4","DOIUrl":"10.1007/s12265-024-10552-4","url":null,"abstract":"The study investigates the utility of heart fatty-acid binding protein (H-FABP) in distinguishing TIA from mimics. Data from 175 patients from the StrokeChip multicenter study was retrospectively analyzed. H-FABP level was measured using a rapid point-of-care test. Findings revealed that H-FABP levels were higher in individuals with TIA compared to mimics [3.10 ng/mL (IQR 2.13-4.78) vs. 1.70 ng/mL (IQR 1.23-2.38)] (p < 0.001). The diagnostic performance of H-FABP, assessed using the area under the curve operating characteristic curve (AUC) was 0. 83 (95% CI = 0.76-0.90) for the final model, indicating good discriminative ability. The PanelomiX determined that a combined cutoff of > 1.85 ng/ml for H-FABP, age > 42.5 years, and baseline NIHSS > 3.5 had a 100% of sensitivity and 23.30% of specificity. The study suggests that H-FABP has potential as a TIA diagnostic biomarker. The rapid application of POCT's for H-FABP measurement supports its potential use in emergency departments and primary care settings.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"40-47"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0