Journal of Cardiovascular Translational Research最新文献_第2页

Mydgf Enhances Cardiac Angiogenesis by Upregulating FGF1. Mydgf通过上调FGF1促进心脏血管生成。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-24 DOI: 10.1007/s12265-025-10641-y

Yuyao Wang, Weijing Liu, Yanyan Hao, Songrui Jia, Miaoqing Hu, Jie Feng, Yu Nie, Lina Bai

{"title":"Mydgf Enhances Cardiac Angiogenesis by Upregulating FGF1.","authors":"Yuyao Wang, Weijing Liu, Yanyan Hao, Songrui Jia, Miaoqing Hu, Jie Feng, Yu Nie, Lina Bai","doi":"10.1007/s12265-025-10641-y","DOIUrl":"https://doi.org/10.1007/s12265-025-10641-y","url":null,"abstract":"Following myocardial infarction (MI), endothelial cell proliferation drives neovascularization to support cardiac regeneration. While myeloid-derived growth factor (Mydgf) is known to promote cardiac repair post-injury, yet its mechanism in angiogenesis remained unclear. In this study, we found that myeloid-derived growth factor knockout (Mydgf-KO) reduced endothelial cell proliferation during early postnatal cardiac angiogenesis and impaired neovascularization post-MI, leading to exacerbated cardiac dysfunction. Recombinant MYDGF therapy reversed these deficits. Liquid chromatography mass spectrometry analysis (LC-MS) analysis of cardiac ECM in Mydgf-KO mice revealed FGF1 as a critical downstream effector of Mydgf in angiogenesis. Administration of recombinant FGF1 protein significantly promoted endothelial cell proliferation and tube formation in human coronary artery endothelial cells. These findings establish the Mydgf-FGF1 axis as a critical regulator of cardiac angiogenesis and unveil its promise as a therapeutic target to promote vascular repair in ischemic heart disease.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Immediate Cardiovascular and Mitochondrial Response in Ischemic Cardiogenic Shock. 缺血性心源性休克的即时心血管和线粒体反应。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-24 DOI: 10.1007/s12265-025-10647-6

Oskar Kjærgaard Hørsdal, Peter Hartmund Frederiksen, Ole Kristian Lerche Helgestad, Hanne Berg Ravn, Jacob Eifer Møller, Henrik Wiggers, Roni Ranghøj Nielsen, Nigopan Gopalasingam, Kristoffer Berg-Hansen

{"title":"The Immediate Cardiovascular and Mitochondrial Response in Ischemic Cardiogenic Shock.","authors":"Oskar Kjærgaard Hørsdal, Peter Hartmund Frederiksen, Ole Kristian Lerche Helgestad, Hanne Berg Ravn, Jacob Eifer Møller, Henrik Wiggers, Roni Ranghøj Nielsen, Nigopan Gopalasingam, Kristoffer Berg-Hansen","doi":"10.1007/s12265-025-10647-6","DOIUrl":"https://doi.org/10.1007/s12265-025-10647-6","url":null,"abstract":"The acute pathophysiological changes after myocardial ischemia complicated by cardiogenic shock (CS) remain poorly defined, especially regarding compensatory mechanisms and myocardial mitochondrial function. We investigated immediate cardiovascular and mitochondrial effects in a porcine model of ischemic CS. CS was induced in 32 Danish Landrace pigs (60 kg) via repeated microembolization of the left coronary artery until a 30% reduction in cardiac output (CO) or mixed venous saturation. Monitoring included pulmonary artery and left ventricular pressure-volume catheters, with analysis of endomyocardial biopsies and arterial, mixed venous, and coronary sinus blood samples. CO deteriorated promptly due to decreased stroke volume. Contractility declined, and afterload increased, causing rapid ventriculo-arterial decoupling. Forward flow parameters were compromised prior to pressure-parameters. Diastolic function was impaired and mitochondrial damage was observed. CS rapidly impairs LV hemodynamic and mitochondrial function, highlighting the importance of monitoring forward flow and targeting mitochondrial function in treatment.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation Between NLR to Albumin Ratio and 90-day Prognosis After Treatment for Acute Ischemic Stroke. 急性缺血性脑卒中患者NLR与白蛋白比值与90天预后的关系

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-24 DOI: 10.1007/s12265-025-10643-w

Peian Liu, Lianhong Ji, Jiale Gan, Xinyi Yang, Yongxing Deng, Junqi Liao, Peiyi Mo, Qing Zhu, Hui Jiang, Yunfei Han, Zhaoyao Chen, Wenlei Li, Minghua Wu, Yuan Zhu

{"title":"Correlation Between NLR to Albumin Ratio and 90-day Prognosis After Treatment for Acute Ischemic Stroke.","authors":"Peian Liu, Lianhong Ji, Jiale Gan, Xinyi Yang, Yongxing Deng, Junqi Liao, Peiyi Mo, Qing Zhu, Hui Jiang, Yunfei Han, Zhaoyao Chen, Wenlei Li, Minghua Wu, Yuan Zhu","doi":"10.1007/s12265-025-10643-w","DOIUrl":"https://doi.org/10.1007/s12265-025-10643-w","url":null,"abstract":"The prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) in relation to albumin levels for acute ischemic stroke (AIS) remains unclear. This study examined the correlation between inflammatory markers and nutritional status to predict 90-day outcomes in patients with AIS. A total of 5855 patients with acute cerebral infarction admitted to the Stroke Center at Jiangsu Province Hospital of Chinese Medicine between June 2017 and September 2023 were retrospectively analyzed. The NLR, SIRI, SII, and NLR-ALb were calculated using peripheral venous blood indicators obtained 24 h post-admission. All patients were followed up 90 days after discharge, and their prognosis was evaluated using the modified Rankin Scale (mRS). Logistic regression analysis, receiver operating characteristics, and Kaplan-Meier survival curves were used to explore the association between inflammatory markers and 90-day outcomes in patients with AIS. In conclusion, higher levels of NLR, SIRI, SII, and the NLR-ALB ratio are associated with poor outcomes following AIS.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a Nomogram Model to Predict the Risk of Postoperative Delirium in Cardiac Surgery Patients. 预测心脏手术患者术后谵妄风险的Nomogram模型的建立。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-24 DOI: 10.1007/s12265-025-10640-z

Zikomo Gaudence Kipanga, Zexiang Bao, Marvel Gyeyock Tella, Emmanuel Delali Kofi Fiagbey, Salama Habibu Saad, Bongani Mbambara, Chernor Sulaiman Bah, Asha Khatib Iddi, Rui Ding, Yanna Si, Yuan Zhang, Jianjun Zou

{"title":"Development of a Nomogram Model to Predict the Risk of Postoperative Delirium in Cardiac Surgery Patients.","authors":"Zikomo Gaudence Kipanga, Zexiang Bao, Marvel Gyeyock Tella, Emmanuel Delali Kofi Fiagbey, Salama Habibu Saad, Bongani Mbambara, Chernor Sulaiman Bah, Asha Khatib Iddi, Rui Ding, Yanna Si, Yuan Zhang, Jianjun Zou","doi":"10.1007/s12265-025-10640-z","DOIUrl":"https://doi.org/10.1007/s12265-025-10640-z","url":null,"abstract":"Postoperative delirium (POD) is a common and severe complication following cardiac surgery, with an incidence of about 65% in older patients. This study aimed to develop a predictive model for POD in patients aged ≥ 18 years, to enhance early detection and intervention. A retrospective analysis was performed on the data collected from 825 patients who underwent cardiac surgery at Nanjing First Hospital (May 2021-July 2022). POD was diagnosed using the Confusion Assessment Method for the ICU (CAM-ICU). We used LASSO regression and multivariate logistic regression to identify key predictors for the nomogram. The incidence of POD was 23.6%, with significant predictors including head CT findings, hyperlactatemia before extubation, APACHE II score, ASA score, and length of hospital stay. The model demonstrated strong predictive ability (AUC: 0.922 training, 0.896 validation). A web-based calculator ( https://baozexiang.shinyapps.io/dynnomapp/ ) was developed to enhance clinical risk assessment and patient outcomes.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the Therapeutic Potential of miRNA-137-3p/383-5p/PGC-1α Signalling Nexus Against Cardiac Hypertrophy. 研究miRNA-137-3p/383-5p/PGC-1α信号通路对心肌肥厚的治疗潜力。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-23 DOI: 10.1007/s12265-025-10636-9

Khadam Hussain, Somia Khurram, Muhammad Yousaf, Ayesha Ishtiaq, Iram Mushtaq, Tahir Ali, Iram Murtaza

{"title":"Investigating the Therapeutic Potential of miRNA-137-3p/383-5p/PGC-1α Signalling Nexus Against Cardiac Hypertrophy.","authors":"Khadam Hussain, Somia Khurram, Muhammad Yousaf, Ayesha Ishtiaq, Iram Mushtaq, Tahir Ali, Iram Murtaza","doi":"10.1007/s12265-025-10636-9","DOIUrl":"https://doi.org/10.1007/s12265-025-10636-9","url":null,"abstract":"Pathological growth of cardiomyocytes known as cardiac hypertrophy (CH). Differential expressions of miRNAs have an immense therapeutic potential against cardiac hypertrophy. The current study aim is to evaluate the therapeutic potential of miRNA-137-3p/383-5p in cardiac hypertrophy by regulation of PGC-1α signaling nexus. Silencing of pro-hypertrophic miRNAs e.g. miR-137-3p and miR-383-5p leads to the restoration of their common target gene PGC-1α in hypertrophic cells. Interestingly, the results of this invivo study showed the cardioprotective effects of these antagomirs. Moreover, PGC-1α associated signaling events e.g. fatty acid oxidation (Cpt1a, Cpt1b), mitochondria membrane potential (MMP), mitochondrial reactive oxygen species (mtROS), oxidative phosphorylation (Ndufa6, Atp5me), apoptosis (Bcl-2, BAX), antioxidants (SOD, GSH, CAT), mitochondrial dynamic (Mfn-2, Drp-1) were significantly restored in the treated groups of miRNA antagomirs. Conclusively, this study uncovers that the pharmacological inhibition of miR-137-3p and miR-383-5p have a potential to rescue from the cardiac hypertrophy by regulation of PGC-1α signaling nexus.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating Extracellular Vesicles Predict Complications after Cardiac Surgery. 循环细胞外囊泡预测心脏手术后并发症。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-23 DOI: 10.1007/s12265-025-10642-x

Yu-Peng Jian, Yue-Ming Peng, Xiao-Jun Liu, Jing-Song Ou

引用次数: 0

Distinct Myocardial Remodelling Profiles in Athletes: A Comparative Analysis Across Sporting Disciplines. 不同的心肌重构概况在运动员：跨运动学科的比较分析。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-20 DOI: 10.1007/s12265-025-10639-6

Zayed M Altowerqi

引用次数: 0

The Individual and Joint Associations of Systolic Blood Pressure Variability and Arterial Stiffness with Cardiovascular Disease: A Prospective Cohort Study. 收缩压变异性和动脉僵硬度与心血管疾病的个体和联合关联：一项前瞻性队列研究

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-20 DOI: 10.1007/s12265-025-10644-9

Ming Gao, Wei Pan, Tianqi Ma, Qunyong Pen, Rong Cao, Chenxuan Zhao, Jun Yi

引用次数: 0

Identification of Plasma Lipidomic Signatures Associated with Coronary Plaque Vulnerability. 鉴定与冠状动脉斑块易损性相关的血浆脂质组学特征。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-20 DOI: 10.1007/s12265-025-10646-7

Yanyan Gong, Chen Zhao, Lixin Jia, Bokang Qiao, Jinwei Tian, Haichu Wen, Yuan Wang, Bo Yu, Jie Du

{"title":"Identification of Plasma Lipidomic Signatures Associated with Coronary Plaque Vulnerability.","authors":"Yanyan Gong, Chen Zhao, Lixin Jia, Bokang Qiao, Jinwei Tian, Haichu Wen, Yuan Wang, Bo Yu, Jie Du","doi":"10.1007/s12265-025-10646-7","DOIUrl":"10.1007/s12265-025-10646-7","url":null,"abstract":"The objective of this study was to identify plasma lipid signatures associated with plaque vulnerability. We retrospectively evaluated coronary plaque in 99 patients using optical coherence tomography (OCT) and quantified 489 plasma lipids. We identified intra- and inter-class crosstalk among ceramide (Cer)-phosphatidylinositol (PI)-esterified cholesterol (CE)-sphingomyelin (SM) (Cer-PI-CE-SM) in patients with thin-cap fibroatheroma (TCFA). CE-16:0, SM d18:1/16:1, and GM3 d18:1/22:0, emerged as potential markers of TCFA, correlating with the thinnest fibrous cap thickness and the presence of cholesterol crystallization. Compared to the clinical model (area under the curve [AUC] = 0.810), the AUC of the combined clinical-lipid model improved [AUC = 0.880, p = 0.032]. Calibration and decision curves demonstrated that the combined model exhibited superior diagnostic performance. We identified lipid molecules that are strongly correlated with plaque vulnerability, thus providing an option for the non-invasive identification of vulnerable plaques, which could potentially facilitate the tailored treatment for high-risk patients.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosomal miRNAs: A New Frontier in Cardiovascular Disease Diagnosis and Treatment. 外泌体mirna：心血管疾病诊断和治疗的新前沿。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-19 DOI: 10.1007/s12265-025-10617-y

Sun Qingpiao, Zhang Yi

引用次数: 0