Journal of Cardiovascular Translational Research最新文献_第2页

LACC1 Enhances Polyamine Immunometabolism in Inflammatory Macrophages to Inhibit Atherosclerosis Progression. LACC1增强炎性巨噬细胞多胺免疫代谢抑制动脉粥样硬化进展

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-04-28 DOI: 10.1007/s12265-024-10585-9

Jingyong Zhang, Yuan Xu, Zonglin Han, Bingqi Liu, Maohua Wang, Lili Bao, Yuxiang He

{"title":"LACC1 Enhances Polyamine Immunometabolism in Inflammatory Macrophages to Inhibit Atherosclerosis Progression.","authors":"Jingyong Zhang, Yuan Xu, Zonglin Han, Bingqi Liu, Maohua Wang, Lili Bao, Yuxiang He","doi":"10.1007/s12265-024-10585-9","DOIUrl":"https://doi.org/10.1007/s12265-024-10585-9","url":null,"abstract":"To explore the function and potential mechanism of laccase domain-containing 1 (LACC1) on atherosclerosis (AS). ApoE-/- mice feed with high-fat diet (HFD) were injected with adenovirus shLACC1 (Ad-shLACC1) or Ad-shNC via tail vein. LACC1 was highly expressed in macrophages of atherosclerotic plaque in ApoE-/- mice and ox-LDL-treated Raw264.7 macrophages. LACC1 silencing enhanced AS development and facilitated inflammation in mice. Then, we found that LACC1 silencing facilitated inflammation but repressed polyamine immunometabolism in ox-LDL-treated Raw264.7 macrophages. Through rescue experiments using ornithine or ODC1 inhibitor (DFMO), we further confirmed that LACC1 promoted polyamine immunometabolism to inhibit inflammation in ox-LDL-treated Raw264.7 macrophages. In addition, the observed LACC1 function was dependent on NOS2. In conclusion, we proved that the downregulation of LACC1 promoted AS progression via inhibiting polyamine immunometabolism in inflammatory macrophages, suggesting LACC1 may be a potential therapeutic target for AS.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of The Relationship Between Differential Small Molecule Peptides in Peripheral Blood and Arteriosclerosis in Patients with Essential Hypertension. 高血压患者外周血差异小分子肽与动脉硬化关系的研究。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-04-22 DOI: 10.1007/s12265-025-10616-z

Yunfeng Fang, Jingwen Yue, Min Zhang, Li Jiang

引用次数: 0

Inhibition of VSMC Ferroptosis Mitigates Pathological Vascular Remodeling: A Novel Therapeutic Strategy for Abdominal Aortic Aneurysm. 抑制VSMC上睑下垂减轻病理性血管重塑：一种治疗腹主动脉瘤的新策略。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-04-21 DOI: 10.1007/s12265-025-10621-2

Yating Zhou, Yanyu Chen, Yuting Cui, Ni Gan, Qiong Xiang, Man Li, Wen Zeng, Xi-Long Zheng, Xiaoyan Dai, Juan Peng, Zhihan Tang

{"title":"Inhibition of VSMC Ferroptosis Mitigates Pathological Vascular Remodeling: A Novel Therapeutic Strategy for Abdominal Aortic Aneurysm.","authors":"Yating Zhou, Yanyu Chen, Yuting Cui, Ni Gan, Qiong Xiang, Man Li, Wen Zeng, Xi-Long Zheng, Xiaoyan Dai, Juan Peng, Zhihan Tang","doi":"10.1007/s12265-025-10621-2","DOIUrl":"https://doi.org/10.1007/s12265-025-10621-2","url":null,"abstract":"Ferroptosis plays a key role in abdominal aortic aneurysm (AAA) development. This study explores whether and how ferroptosis regulates AAA progression. Ferroptosis was confirmed in human AAA tissue. In vitro experiments with primary mouse vascular smooth muscle cells (VSMCs) and abdominal aortic rings revealed that angiotensin II (Ang II) triggered ferroptosis in VSMCs. Ferrostatin-1 (Fer-1), a potent ferroptosis inhibitor, effectively suppressed this effect. Additionally, the ferroptosis inducer erastin and Ang II can both promoted pathological remodeling of abdominal aortic rings, but Fer-1 significantly suppressed these effects. In AAA mouse model, Fer-1 treatment reduced AAA formation. Mechanistically, RNA-sequencing analysis revealed that Fer-1 regulates VSMC contractile function, suppresses inflammation, and mitigates extracellular matrix remodeling. These findings highlight the critical role of VSMC ferroptosis in AAA pathogenesis and demonstrate that ferroptosis inhibition effectively reduces pathological vascular remodeling, making it a promising therapeutic strategy for preventing AAA.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fracture and Fragmentation of Vascular Calcifications by Focused Ultrasound. 聚焦超声对血管钙化骨折和碎裂的影响。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-04-21 DOI: 10.1007/s12265-025-10611-4

Lucas Su Chen, Gabriel Koh, Yak-Nam Wang, Ga Won Kim, Zorawar Singh, Adrienne Lehnert, Robert Miyaoka, Hitinder S Gurm, Adam D Maxwell

{"title":"Fracture and Fragmentation of Vascular Calcifications by Focused Ultrasound.","authors":"Lucas Su Chen, Gabriel Koh, Yak-Nam Wang, Ga Won Kim, Zorawar Singh, Adrienne Lehnert, Robert Miyaoka, Hitinder S Gurm, Adam D Maxwell","doi":"10.1007/s12265-025-10611-4","DOIUrl":"https://doi.org/10.1007/s12265-025-10611-4","url":null,"abstract":"Peripheral artery disease results in ischemia necessitating interventions such as balloon angioplasty. However, calcified lesions resist balloon and stent expansion, leading to poor outcomes. We hypothesized that focused ultrasound can fracture vascular calcifications and enable balloon angioplasty. In a first experiment, focused ultrasound was applied to ex vivo human calcified plaque specimens to determine its effects based on micro-CT imaging. In a second experiment, ultrasound was applied to an in vitro phantom to evaluate whether the effects enable balloon expansion. Fractures, thinning, and disintegration of calcified sections were observed in 15 of 18 treated human plaque samples. Minor mechanical disruption to soft plaque was found in 33% of samples. In tissue phantoms, n = 10/10 samples were successfully expanded by a water-filled angioplasty balloon with ultrasound applied prior to or during expansion. No controls (n = 0/10) were expanded. These results indicate focused-ultrasound plaque fracture is feasible and may enhance balloon angioplasty.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Metabolic Signature Specific to the Patients with Type 2 Diabetes and its Association with the Pathogenesis of Diabetic-Foot Syndrome. 2型糖尿病患者特有的代谢特征及其与糖尿病足综合征发病机制的关系

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-04-16 DOI: 10.1007/s12265-025-10622-1

Tao Wang, Ziyu Su, Ming Zhong, Xuanqin Wu, Liang Li, Hong Gu, Yunhan Sun, Jun Ji, Xingchun Peng

引用次数: 0

Glycerophospholipid and Sphingosine- 1-phosphate Metabolism in Cardiovascular Disease: Mechanisms and Therapeutic Potential. 甘油磷脂和鞘氨醇- 1-磷酸在心血管疾病中的代谢：机制和治疗潜力。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-04-14 DOI: 10.1007/s12265-025-10620-3

Huiru Tang, Chengxia Kan, Kexin Zhang, Sufang Sheng, Hongyan Qiu, Yujie Ma, Yuqun Wang, Ningning Hou, Jingwen Zhang, Xiaodong Sun

{"title":"Glycerophospholipid and Sphingosine- 1-phosphate Metabolism in Cardiovascular Disease: Mechanisms and Therapeutic Potential.","authors":"Huiru Tang, Chengxia Kan, Kexin Zhang, Sufang Sheng, Hongyan Qiu, Yujie Ma, Yuqun Wang, Ningning Hou, Jingwen Zhang, Xiaodong Sun","doi":"10.1007/s12265-025-10620-3","DOIUrl":"https://doi.org/10.1007/s12265-025-10620-3","url":null,"abstract":"Cardiovascular disease remains a leading cause of mortality worldwide, driven by factors such as dysregulated lipid metabolism, oxidative stress, and inflammation. Recent studies highlight the critical roles of both glycerophospholipid and sphingosine- 1-phosphate metabolism in the pathogenesis of cardiovascular disorders. However, the contributions of glycerophospholipid-derived metabolites remain underappreciated. Glycerophospholipid metabolism generates bioactive molecules that contribute to endothelial dysfunction, lipid accumulation, and cardiac cell injury while also modulating inflammatory and oxidative stress responses. Meanwhile, sphingosine- 1-phosphate is a bioactive lipid mediator that regulates vascular integrity, inflammation, and cardiac remodeling through its G-protein-coupled receptors. The convergence of these pathways presents novel therapeutic opportunities, where dietary interventions such as omega- 3 polyunsaturated fatty acids and pharmacological targeting of sphingosine- 1-phosphate receptors could synergistically mitigate cardiovascular risk. This review underscores the need for further investigation into the interplay between glycerophospholipid metabolism and sphingosine- 1-phosphate signaling to advance targeted therapies for the prevention and management of cardiovascular disease.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Connecting the Dots: Stress Granule and Cardiovascular Diseases. 连接点：压力颗粒和心血管疾病。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-04-14 DOI: 10.1007/s12265-025-10619-w

Gaowei Yang, Yiming Wang, Junfang Guo, Tao Rui

引用次数: 0

Comprehensive Plasma Proteomic Profiling Reveals Differentially Regulated Signaling Pathways Underlying Left Ventricular Hypertrophy Between Hypertrophic Cardiomyopathy and Aortic Stenosis. 综合血浆蛋白质组学分析揭示肥厚性心肌病和主动脉狭窄之间左室肥厚的差异调节信号通路。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-04-14 DOI: 10.1007/s12265-025-10618-x

Heidi S Lumish, Lorenzo R Sewanan, Lusha W Liang, Kohei Hasegawa, Mathew S Maurer, Muredach P Reilly, Yuichi J Shimada

{"title":"Comprehensive Plasma Proteomic Profiling Reveals Differentially Regulated Signaling Pathways Underlying Left Ventricular Hypertrophy Between Hypertrophic Cardiomyopathy and Aortic Stenosis.","authors":"Heidi S Lumish, Lorenzo R Sewanan, Lusha W Liang, Kohei Hasegawa, Mathew S Maurer, Muredach P Reilly, Yuichi J Shimada","doi":"10.1007/s12265-025-10618-x","DOIUrl":"https://doi.org/10.1007/s12265-025-10618-x","url":null,"abstract":"Hypertrophic cardiomyopathy (HCM) is the most common genetic myocardial disease, characterized by asymmetric left ventricular hypertrophy (LVH) due to sarcomeric mutations. Aortic stenosis (AS) results in concentric LVH, due to pressure overload. The aim of this study was to identify signaling pathways differentially regulated in HCM compared to AS, using plasma proteomic profiling. 76 HCM cases and 36 AS controls were matched by age and sex. A machine-learning (ML) model to predict HCM was built in the training set (70% cohort) and examined in the test set (30% cohort). Pathway analysis of proteins differentially expressed between HCM and AS was performed. The ML model accurately distinguished HCM from AS, with area under the receiver operating characteristic curve of 0.90 (95% CI: 0.79-1.00). Pathway analysis revealed differential regulation of Ras-MAPK, inflammatory and metabolic pathways. In conclusion, this study identified distinctive proteomic profiles and signaling pathways underlying LVH in HCM compared to AS.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanotechnology Innovations in Myocardial Infarction: Diagnosis, Treatment and the Way Forward. 纳米技术在心肌梗死中的创新：诊断、治疗和前进的道路。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-04-09 DOI: 10.1007/s12265-025-10614-1

Wenhai Wang, Dexin Xu, Jian Ding, Yinping Pan, Fang Wang, Shu Su, Xia Peng, Shitong Zhang, Wenbin Zhang

{"title":"Nanotechnology Innovations in Myocardial Infarction: Diagnosis, Treatment and the Way Forward.","authors":"Wenhai Wang, Dexin Xu, Jian Ding, Yinping Pan, Fang Wang, Shu Su, Xia Peng, Shitong Zhang, Wenbin Zhang","doi":"10.1007/s12265-025-10614-1","DOIUrl":"https://doi.org/10.1007/s12265-025-10614-1","url":null,"abstract":"Myocardial infarction (MI) is a global health concern that necessitates continued advancements in diagnostic and therapeutic modalities. Nanotechnology facilitates prompt diagnosis and personalized treatment. This manuscript explicitly reviews the application of innovative methodologies for identifying cardiac biomarkers to facilitate the early diagnosis of MI and its clinical management. Nanoscale agents such as nanoparticles and nanosensors have been employed for this purpose. Technological advancements in medical imaging are revolutionizing therapeutic approaches while reducing morbidity and mortality typically associated with cardiac tissue injury. Besides all, applications of nanotechnology in therapeutics have proven extremely effective. The development of nanoparticle-based customized drug delivery systems will contribute to more effective treatments, fewer side effects, and improved therapeutic outcomes. Biomaterials and nanoscale surgical technologies may benefit patients with MI by promoting tissue regeneration and repair. This manuscript also investigates the ethical and legal limitations that could prevent seamless incorporation of nanotechnology into clinical practice.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Opioids on Epigenetic Modulation in Myocardial Ischemia and Reperfusion Injury: Focus on Non-coding RNAs. 阿片类药物对心肌缺血再灌注损伤表观遗传调控的影响：以非编码rna为重点。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-04-08 DOI: 10.1007/s12265-025-10609-y

Mohsen Davari, Mahmoud Khansari, Sahar Hosseini, Reza Morovatshoar, Alireza Azani, Seyedeh Tarlan Mirzohreh, Mohammadjavad Ashrafi Mahabadi, Moein Ghasemi, Mohammad Saeed Soleimani Meigoli, Sima Foroughi Nematollahi, Sina Pourranjbar, Qumars Behfar, Mandana Baghdadi, Ahmad Mir Hosseini

{"title":"The Impact of Opioids on Epigenetic Modulation in Myocardial Ischemia and Reperfusion Injury: Focus on Non-coding RNAs.","authors":"Mohsen Davari, Mahmoud Khansari, Sahar Hosseini, Reza Morovatshoar, Alireza Azani, Seyedeh Tarlan Mirzohreh, Mohammadjavad Ashrafi Mahabadi, Moein Ghasemi, Mohammad Saeed Soleimani Meigoli, Sima Foroughi Nematollahi, Sina Pourranjbar, Qumars Behfar, Mandana Baghdadi, Ahmad Mir Hosseini","doi":"10.1007/s12265-025-10609-y","DOIUrl":"https://doi.org/10.1007/s12265-025-10609-y","url":null,"abstract":"Myocardial ischemia-reperfusion injury (IRI) is a major issue in cardiovascular medicine, marked by tissue damage from the restoration of blood flow after ischemia. Opioids, known for their pain-relieving properties, have emerged as potential cardioprotective agents in IRI. Recent research suggests opioids influence epigenetic mechanisms-such as histone modifications and non-coding RNAs (ncRNAs)-which are essential for regulating gene expression and cellular responses during myocardial IRI. This review delves into how opioids like remifentanil affect histone modifications, DNA methylation, and ncRNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). Remifentanil postconditioning (RPC) reduces apoptosis in cardiomyocytes through histone deacetylation, specifically downregulating histone deacetylase 3 (HDAC3). Similarly, opioids impact miRNAs such as miR- 206 - 3p and miR- 320 - 3p, and lncRNAs like TINCR and UCA1, which influence apoptosis, inflammation, and oxidative stress. Understanding these interactions highlights the potential for opioid-based therapies in mitigating IRI-induced myocardial damage.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0