Journal of Cardiovascular Translational Research最新文献_第2页

Clinical Outcome of Hypertrophic Cardiomyopathy in Probands with the Founder Variant c.913_914del in MYBPC3: A Slovenian Cohort Study. 具有 MYBPC3 基因 c.913_914del 父系变异的肥厚型心肌病患者的临床预后：一项斯洛文尼亚队列研究。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-08-19 DOI: 10.1007/s12265-024-10551-5

Nina Vodnjov, Aleš Maver, Nataša Teran, Borut Peterlin, Janez Toplišek, Karin Writzl

引用次数: 0

H-FABP as a Biomarker in Transient Ischemic Attack. 作为短暂性脑缺血发作生物标志物的 H-FABP

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-08-19 DOI: 10.1007/s12265-024-10552-4

Daisy Guamán-Pilco, Elvira Chocano, Elena Palà, Marcel Lamana-Vallverdú, Anna Penalba, Paula García-Rodríguez, Marta Rubiera, Alejandro Bustamante, Àlex Rovira, Soledad Pérez-Sánchez, Leire Azurmendi, Sandrine Reymond, Jean-Charles Sánchez, Joan Montaner

{"title":"H-FABP as a Biomarker in Transient Ischemic Attack.","authors":"Daisy Guamán-Pilco, Elvira Chocano, Elena Palà, Marcel Lamana-Vallverdú, Anna Penalba, Paula García-Rodríguez, Marta Rubiera, Alejandro Bustamante, Àlex Rovira, Soledad Pérez-Sánchez, Leire Azurmendi, Sandrine Reymond, Jean-Charles Sánchez, Joan Montaner","doi":"10.1007/s12265-024-10552-4","DOIUrl":"https://doi.org/10.1007/s12265-024-10552-4","url":null,"abstract":"The study investigates the utility of heart fatty-acid binding protein (H-FABP) in distinguishing TIA from mimics. Data from 175 patients from the StrokeChip multicenter study was retrospectively analyzed. H-FABP level was measured using a rapid point-of-care test. Findings revealed that H-FABP levels were higher in individuals with TIA compared to mimics [3.10 ng/mL (IQR 2.13-4.78) vs. 1.70 ng/mL (IQR 1.23-2.38)] (p < 0.001). The diagnostic performance of H-FABP, assessed using the area under the curve operating characteristic curve (AUC) was 0. 83 (95% CI = 0.76-0.90) for the final model, indicating good discriminative ability. The PanelomiX determined that a combined cutoff of > 1.85 ng/ml for H-FABP, age > 42.5 years, and baseline NIHSS > 3.5 had a 100% of sensitivity and 23.30% of specificity. The study suggests that H-FABP has potential as a TIA diagnostic biomarker. The rapid application of POCT's for H-FABP measurement supports its potential use in emergency departments and primary care settings.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Kernel Attention-based Transformer Model for Survival Prediction of Heart Disease Patients. 基于核注意力的心脏病患者生存预测变压器模型

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-08-05 DOI: 10.1007/s12265-024-10537-3

Palak Kaushal, Shailendra Singh, Rajesh Vijayvergiya

{"title":"A Kernel Attention-based Transformer Model for Survival Prediction of Heart Disease Patients.","authors":"Palak Kaushal, Shailendra Singh, Rajesh Vijayvergiya","doi":"10.1007/s12265-024-10537-3","DOIUrl":"https://doi.org/10.1007/s12265-024-10537-3","url":null,"abstract":"Survival analysis is employed to scrutinize time-to-event data, with emphasis on comprehending the duration until the occurrence of a specific event. In this article, we introduce two novel survival prediction models: CosAttnSurv and CosAttnSurv <math><mo>+</mo></math> DyACT. CosAttnSurv model leverages transformer-based architecture and a softmax-free kernel attention mechanism for survival prediction. Our second model, CosAttnSurv <math><mo>+</mo></math> DyACT, enhances CosAttnSurv with Dynamic Adaptive Computation Time (DyACT) control, optimizing computation efficiency. The proposed models are validated using two public clinical datasets related to heart disease patients. When compared to other state-of-the-art models, our models demonstrated an enhanced discriminative and calibration performance. Furthermore, in comparison to other transformer architecture-based models, our proposed models demonstrate comparable performance while exhibiting significant reduction in both time and memory requirements. Overall, our models offer significant advancements in the field of survival analysis and emphasize the importance of computationally effective time-based predictions, with promising implications for medical decision-making and patient care.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging Paradigms in Atherosclerosis: The Impact of LncRNA PSMB8-AS1 on Vascular Inflammation and Plaque Formation. 动脉粥样硬化的新范例：LncRNA PSMB8-AS1 对血管炎症和斑块形成的影响。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-08-01 Epub Date: 2024-01-19 DOI: 10.1007/s12265-024-10481-2

Xi-Long Zheng

引用次数: 0

The Role and Potential Mechanisms of Rehabilitation Exercise Improving Cardiac Remodeling. 康复锻炼改善心脏重塑的作用和潜在机制

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-08-01 Epub Date: 2024-04-01 DOI: 10.1007/s12265-024-10498-7

Haizhu Gao, Zhongxin Li, Lijun Gan, Xueying Chen

引用次数: 0

Percutaneous Alginate Hydrogel Endomyocardial Injection with a Novel Dedicated Catheter Delivery System: An Animal Feasibility Study. 使用新型专用导管输送系统进行经皮藻酸水凝胶心内膜注射：动物可行性研究

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-08-01 Epub Date: 2024-02-20 DOI: 10.1007/s12265-024-10497-8

Bo Wang, Chao Gao, Scott Lim, Rutao Wang, Cun-Jun Zhu, Yoshinobu Onuma, Yunbing Wang, Runlin Gao, Patrick W J C Serruys, Randall J Lee, Ling Tao

{"title":"Percutaneous Alginate Hydrogel Endomyocardial Injection with a Novel Dedicated Catheter Delivery System: An Animal Feasibility Study.","authors":"Bo Wang, Chao Gao, Scott Lim, Rutao Wang, Cun-Jun Zhu, Yoshinobu Onuma, Yunbing Wang, Runlin Gao, Patrick W J C Serruys, Randall J Lee, Ling Tao","doi":"10.1007/s12265-024-10497-8","DOIUrl":"10.1007/s12265-024-10497-8","url":null,"abstract":"The objective of this preclinical study was to evaluate the feasibility and safety of transcatheter endocardial alginate hydrogel injection (TEAi) in a large animal model, utilizing the high-stiffness XDROP® alginate hydrogel in combination with the dedicated EndoWings® catheter-based system. All swine (n = 9) successfully underwent TEAi without complications. Acute results from a subset of animals (n = 5) demonstrated the ability of the catheter to access a wide range of endomyocardial areas and achieve consecutive circumferential hydrogel distribution patterns within the mid-left ventricular wall. Histological examinations at 6 months (n = 4) demonstrated that the XDROP® remained localized within the cardiac tissue. In addition, serial echocardiographic imaging showed that XDROP® had no adverse impacts on LV systolic and diastolic functions. In conclusion, this innovative combination technology has the potential to overcome the translational barriers related to alginate hydrogel delivery to the myocardium.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11371841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139905719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficient Edge-AI Models for Robust ECG Abnormality Detection on Resource-Constrained Hardware. 在资源有限的硬件上利用高效边缘人工智能模型进行稳健的心电图异常检测

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-08-01 Epub Date: 2024-03-12 DOI: 10.1007/s12265-024-10504-y

Zhaojing Huang, Luis Fernando Herbozo Contreras, Wing Hang Leung, Leping Yu, Nhan Duy Truong, Armin Nikpour, Omid Kavehei

{"title":"Efficient Edge-AI Models for Robust ECG Abnormality Detection on Resource-Constrained Hardware.","authors":"Zhaojing Huang, Luis Fernando Herbozo Contreras, Wing Hang Leung, Leping Yu, Nhan Duy Truong, Armin Nikpour, Omid Kavehei","doi":"10.1007/s12265-024-10504-y","DOIUrl":"10.1007/s12265-024-10504-y","url":null,"abstract":"This study introduces two models, ConvLSTM2D-liquid time-constant network (CLTC) and ConvLSTM2D-closed-form continuous-time neural network (CCfC), designed for abnormality identification using electrocardiogram (ECG) data. Trained on the Telehealth Network of Minas Gerais (TNMG) subset dataset, both models were evaluated for their performance, generalizability capacity, and resilience. They demonstrated comparable results in terms of F1 scores and AUROC values. The CCfC model achieved slightly higher accuracy, while the CLTC model showed better handling of empty channels. Remarkably, the models were successfully deployed on a resource-constrained microcontroller, proving their suitability for edge device applications. Generalization capabilities were confirmed through the evaluation on the China Physiological Signal Challenge 2018 (CPSC) dataset. The models' efficient resource utilization, occupying 70.6% of memory and 9.4% of flash memory, makes them promising candidates for real-world healthcare applications. Overall, this research advances abnormality identification in ECG data, contributing to the progress of AI in healthcare.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11371854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140110356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Perivascular Adipose Tissue on Neointimal Formation Following Endovascular Placement. 血管周围脂肪组织对血管内置入后新内膜形成的影响

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-08-01 Epub Date: 2024-02-26 DOI: 10.1007/s12265-024-10502-0

Belay Tesfamariam

引用次数: 0

Myocardial Involvement after SARS-CoV-2 Vaccination in Asymptomatic Adolescents: Correspondence. 无症状青少年接种 SARS-CoV-2 疫苗后心肌受累：通信。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-08-01 Epub Date: 2024-02-13 DOI: 10.1007/s12265-024-10494-x

Hinpetch Daungsupawong, Viroj Wiwanitkit

引用次数: 0

Allograft Model of Aortic Arch Segment Grafting to Abdominal Aorta Through End-to-Side Anastomosis in Mice. 通过端侧吻合将主动脉弓段移植到腹主动脉的小鼠同种异体移植模型。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-08-01 Epub Date: 2024-02-26 DOI: 10.1007/s12265-024-10495-w

Chiyu Liu, Qi Chen, Mingyuan He, Yulin Liao

{"title":"Allograft Model of Aortic Arch Segment Grafting to Abdominal Aorta Through End-to-Side Anastomosis in Mice.","authors":"Chiyu Liu, Qi Chen, Mingyuan He, Yulin Liao","doi":"10.1007/s12265-024-10495-w","DOIUrl":"10.1007/s12265-024-10495-w","url":null,"abstract":"The mouse aortic transplantation model is a valuable tool for investigating the mechanisms of atherosclerosis regression, but few laboratories can generate it due to the operation difficulty, especially for the style of end-to-side anastomosis, which facilitates syngeneic heterotopic transplanting a plaque-rich aortic arch into the abdominal aorta. Here we provide a modified protocol for generating this allograft model, which is capable of overcoming several critical surgical challenges such as separating a longer abdominal aorta segment, reducing bleeding and thrombosis, optimizing aortotomy, and improving end-to-side anastomosis to guarantee a potent graft. By transplanting plaque-rich aortic arches into the abdominal aorta of wildtype mice, a high operation success rate (over 90%) was noted with aortic clamping time under 60 min, the graft potency was satisfactory evidenced by examinations of micro-CT, ultrasound, and lower limb blood flow measurement, while a significant atherosclerosis regression was observed in the grafts at 1 week after transplantation.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11371875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139972026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0