Journal of Cardiovascular Translational Research最新文献_第3页

Collagen Prolyl 4-Hydroxylase: An Emerging Key Player in Cardiac Fibrosis. 胶原脯氨酸- 4-羟化酶：在心脏纤维化中的关键作用。

IF 2.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2026-09-08 DOI: 10.1007/s12265-026-10843-y

Wei Hua, Zai-Xin Yu, Li-Huang Zha

引用次数: 0

Alamandine Attenuates Hypoxia-Induced Atrial Fibrillation in Rats: Involvement of Endoplasmic Reticulum Stress and Pyroptosis Pathways. almanmanine减轻大鼠缺氧引起的心房颤动：内质网应激和焦亡通路的参与。

IF 2.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2026-09-05 DOI: 10.1007/s12265-026-10837-w

Lijia Yang, Wenwen Yang, Mengzhu Zhou, Kangyin Chen, Tong Liu, Xuewen Wang, Changle Liu

引用次数: 0

Innovation and Challenges in Materials for Transcatheter Aortic Valves. 经导管主动脉瓣材料的创新与挑战。

IF 2.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2026-09-05 DOI: 10.1007/s12265-026-10840-1

Pramod Dorishetty, Aden Carlton, Leon Neethling, Filippo Valente

{"title":"Innovation and Challenges in Materials for Transcatheter Aortic Valves.","authors":"Pramod Dorishetty, Aden Carlton, Leon Neethling, Filippo Valente","doi":"10.1007/s12265-026-10840-1","DOIUrl":"10.1007/s12265-026-10840-1","url":null,"abstract":"Transcatheter Aortic valve implantation (TAVI) procedure has been revolutionizing the Aortic Stenosis (AS) treatment over the last 20 years, because of its minimally invasive approach and fast postoperative recovery. However, innovation in valve material compatible with TAVI procedure present significant challenges, as they must endure the demanding conditions of catheter-based delivery. This review outlines the fundamental material requirements and challenges in the design and manufacturing of TAVI valves. It compares the existing TAVI devices made from animal tissues and polymers, and identifies the key factors that are limiting their adoption for widespread clinical use. While biological valves remain the predominant choice in current clinical TAVI practice, major future innovation is likely to arise from advances in polymer science aimed at overcoming the key limitations like calcification and limited durability. Fully polymeric valve systems are still at an early stage of development, but they hold considerable long-term potential due to their tunable mechanical properties, resistance to calcification, and potential for scalable manufacturing, that could revolutionize the field.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":"19 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13550074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Trajectory of Epigenetic Chromatin Remodeling in Cardiometabolic Disease and its Therapeutic Implications. 表观遗传染色质重塑在心脏代谢疾病中的轨迹及其治疗意义。

IF 2.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2026-08-28 DOI: 10.1007/s12265-026-10820-5

Mirjana Macvanin, Aleksandra Klisic

引用次数: 0

AMPKγ2-Myosin Interaction: A Glycogen-Independent Trigger for PRKAG2 Cardiomyopathy. ampkγ - 2-肌球蛋白相互作用：PRKAG2心肌病的糖原独立触发。

IF 2.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2026-08-28 DOI: 10.1007/s12265-026-10835-y

Jiaxin Song, Yujiao Zhu, Yanjuan Lin, Yihua Bei

引用次数: 0

Emerging Myostatin and Metabolic Hormone Pathway Modulators in Cardiometabolic Disease: Mechanisms, Evidence, and Therapeutic Potential. 心脏代谢疾病中新出现的肌生长抑制素和代谢激素通路调节剂：机制、证据和治疗潜力。

IF 2.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2026-08-27 DOI: 10.1007/s12265-026-10839-8

Abiya Ahad, Darshan Hullon, Mandana Akhavan, Zahra Oskouyan

{"title":"Emerging Myostatin and Metabolic Hormone Pathway Modulators in Cardiometabolic Disease: Mechanisms, Evidence, and Therapeutic Potential.","authors":"Abiya Ahad, Darshan Hullon, Mandana Akhavan, Zahra Oskouyan","doi":"10.1007/s12265-026-10839-8","DOIUrl":"10.1007/s12265-026-10839-8","url":null,"abstract":"Cardiometabolic disease comprises obesity, type 2 diabetes, heart failure, and sarcopenic obesity, which share interconnected mechanisms including muscle wasting, metabolic dysfunction, fibrosis, mitochondrial impairment, and chronic inflammation. Current therapies primarily target individual risk factors rather than these shared pathways. This review summarizes mechanistic and translational evidence on three emerging pathway modulators-myostatin (MSTN), fibroblast growth factor 21 (FGF21), and growth differentiation factor 15 (GDF15)-and their integration with incretin biology, AMPK/mTOR signaling, fibrosis, and metabolic regulation. Myostatin inhibition increases lean body mass but has shown inconsistent functional benefits. FGF21 analogs improve insulin sensitivity, lipid metabolism, hepatic steatosis, and cardiac energetics. GDF15 functions as both a biomarker and therapeutic target for metabolic stress and cachexia, while GLP-1/GIP therapies favorably influence inflammation, fibrosis, and substrate utilization. Coordinated modulation of these pathways, supported by precision phenotyping and biomarker-guided monitoring, offers a promising strategy for comprehensive cardiometabolic remodeling.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":"19 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic Signatures of Atrial Functional Impairment in Paroxysmal Atrial Fibrillation Patients: A CMR Strain-metabolomics Study. 阵发性心房颤动患者心房功能损害的代谢特征：CMR菌株代谢组学研究

IF 2.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2026-08-24 DOI: 10.1007/s12265-026-10833-0

Tianyi Shi, Bin Liu, Xiaoyu Lian, Chao Peng, Yanjing Wang, Wendi Shi, Heyuan Chen, Sihui He, Huan Sun

引用次数: 0

Right Heart Remodeling and Autonomic Function After Atrial Septal Defect Closure in Children: Surgical Versus Transcatheter Approaches. 儿童房间隔缺损关闭后右心重塑和自主神经功能：手术与经导管入路。

IF 2.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2026-08-13 DOI: 10.1007/s12265-026-10831-2

Nida Gülderen Kalay Şentürk, Ali Karakaş, Samed Cihad Çelik, Hazal Cansu Çulpan, İlker Kemal Yücel, Reyhan Dedeoğlu

{"title":"Right Heart Remodeling and Autonomic Function After Atrial Septal Defect Closure in Children: Surgical Versus Transcatheter Approaches.","authors":"Nida Gülderen Kalay Şentürk, Ali Karakaş, Samed Cihad Çelik, Hazal Cansu Çulpan, İlker Kemal Yücel, Reyhan Dedeoğlu","doi":"10.1007/s12265-026-10831-2","DOIUrl":"10.1007/s12265-026-10831-2","url":null,"abstract":"Atrial septal defect (ASD) closure relieves chronic right ventricular (RV) volume overload; however, the extent to which RV mechanics and autonomic regulation normalize in the mid-term remains uncertain. Patients with isolated secundum ASD who had undergone surgical or transcatheter closure were compared with healthy controls of similar age, sex, and body surface area. Despite successful closure, ASD patients demonstrated subclinical impairment in RV systolic function and persistent enlargement of parasternal RV end-diastolic diameter (p < 0.001). Autonomic assessment revealed a higher LF/HF ratio despite preserved parasympathetic indices, indicating subtle sympathovagal imbalance. Right atrial size correlated positively with parasympathetic markers (RMSSD, pNN50) and inversely with LF/HF. Surgically treated patients exhibited lower TAPSE values and a higher prevalence of abnormal RV S' compared with transcatheter closure. These findings suggest that ASD closure does not uniformly restore RV mechanics or autonomic balance. Larger prospective studies are needed to clarify the clinical significance of these observations.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":"19 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148724912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Gut Microbiota Dysbiosis and Bilirubin Metabolism Dysregulation in Children with Heart Failure. 心衰患儿肠道菌群失调与胆红素代谢失调的关系

IF 2.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2026-08-13 DOI: 10.1007/s12265-026-10834-z

Wei Wei, Lisi Zhou, Yuan Huang, Zhongyuan Lu, Rongyuan Zhang, Ming Zeng, Xu Wang

{"title":"Association Between Gut Microbiota Dysbiosis and Bilirubin Metabolism Dysregulation in Children with Heart Failure.","authors":"Wei Wei, Lisi Zhou, Yuan Huang, Zhongyuan Lu, Rongyuan Zhang, Ming Zeng, Xu Wang","doi":"10.1007/s12265-026-10834-z","DOIUrl":"10.1007/s12265-026-10834-z","url":null,"abstract":"Patients with heart failure (HF) demonstrate dysregulation in bilirubin metabolism. The specific characteristics of intestinal bilirubin metabolism in HF remain unclear. This study involved metagenomic sequencing and metabolomic profiling of fecal samples from 45 children with HF and 32 healthy children. Serum total bilirubin levels were 11.3umol/L, 19.4umol/L and 5.0umol/L in HF New York Heart Association (NYHA) I-II, NYHA III-IV and control group (p < 0.001 ), and the median gut microbiome health index (GMHI) were - 0.78, -1.53 and 0.09 in each (p < 0.001). The abundance of 2 bacteria species containing bilirubin reductase, Ruminococcus gnavus (p = 0.028) and Clostridium sp.M62/1 (p = 0.002) significantly decreased in NYHA III-IV group. The gut downstream bilirubin products, urobilinogen and stercobilin were decreased in the HF group; while the upstream bilirubin products, unconjugated and conjugated bilirubin increased. Dysbiosis of the gut microbiome and the decrease of bilirubin reductase containing bacteria in pediatric HF patients related to a reduction in gut bilirubin metabolism.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":"19 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148760323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic Evaluation of Vascular Remodeling and Aneurysm Progression Using Blood-Pool Contrast-Enhanced In Vivo Micro-CT in a Rodent Model. 在啮齿类动物模型中使用血池增强显微ct动态评估血管重构和动脉瘤进展。

IF 2.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2026-08-13 DOI: 10.1007/s12265-026-10825-0

Amber Hendrickx, Margaux Schols, Geert Maleux, Kasia Błażejczyk, Bart Meuris, Nele Famaey, Filip Rega, Greetje Vande Velde

{"title":"Dynamic Evaluation of Vascular Remodeling and Aneurysm Progression Using Blood-Pool Contrast-Enhanced In Vivo Micro-CT in a Rodent Model.","authors":"Amber Hendrickx, Margaux Schols, Geert Maleux, Kasia Błażejczyk, Bart Meuris, Nele Famaey, Filip Rega, Greetje Vande Velde","doi":"10.1007/s12265-026-10825-0","DOIUrl":"10.1007/s12265-026-10825-0","url":null,"abstract":"Vascular graft remodeling and aneurysm progression are commonly studied in small animal models, but non-terminal methods for their assessment remain limited. This study evaluated contrast-enhanced micro-CT as a tool for longitudinal, in vivo monitoring of vascular grafts in rodents. Using a transplant model in which a pulmonary artery segment was implanted into the recipient's abdominal aorta, creating a pulmonary vascular graft, we compared a molecular iodinated contrast agent with a nanoparticle-based agent. The molecular agent was rapidly cleared, resulting in insufficient vascular opacification for graft visualization or quantification. In contrast, the nanoparticle agent provided prolonged vascular enhancement, enabling high-resolution imaging and quantitative assessment of graft morphology and aneurysm development over time. These findings demonstrate that contrast-enhanced micro-CT, particularly using nanoparticulate blood-pool contrast agents, enables a longitudinal, non-terminal evaluation of vascular grafts in rodents, enabling quantitative monitoring of graft remodeling, overcoming the limitations of traditional post-mortem, single timepoint analyses.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":"19 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148761362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0