Journal of Cardiovascular Translational Research最新文献_第3页

Evaluation of CACNA1C-Positive Patients Evaluated in a Tertiary Genetic Heart Rhythm Clinic. 三级遗传心律临床对cacna1c阳性患者的评价。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-17 DOI: 10.1007/s12265-025-10638-7

Liwei Yu, Raquel Neves, Martijn M Bos, David J Tester, Mayank Sardana, John R Giudicessi, Michael J Ackerman

{"title":"Evaluation of CACNA1C-Positive Patients Evaluated in a Tertiary Genetic Heart Rhythm Clinic.","authors":"Liwei Yu, Raquel Neves, Martijn M Bos, David J Tester, Mayank Sardana, John R Giudicessi, Michael J Ackerman","doi":"10.1007/s12265-025-10638-7","DOIUrl":"https://doi.org/10.1007/s12265-025-10638-7","url":null,"abstract":"Genetic variants in CACNA1C are associated with several cardiac and neurologic conditions. We conducted a retrospective review of patients evaluated and treated who presented with a pathogenic (P), likely pathogenic (LP), or variant of uncertain significance (VUS) in CACNA1C. Among 4,774 patients, 49 had P, LP, or VUS variants (55% female; median age 15 years; mean QTc 481 ms). Of these, 22 had long QT syndrome type 8, 8 had Timothy syndrome, 2 had cardiac only Timothy syndrome, and 9 had no cardiac phenotype. Ten patients exhibited extracardiac findings. Thirty-one patients were treated with a beta-blocker, 21 patients had an implantable cardioverter-defibrillator (ICD). Nine patients were on intentional non-therapy. Six patients had at least 1 breakthrough cardiac event on follow-up. Overall, CACNA1C-positive patients present with diverse diagnoses and severity. Treatments vary by phenotype, however management with preventative measures only presents a reasonable option for some phenotype-negative, genotype-positive patients.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypoxia/reoxygenation-induced Glycolysis Mediates Myocardial Ischemia-reperfusion Injury Through Promoting the Lactylation of GPX4. 缺氧/再氧诱导糖酵解通过促进GPX4的乳酸化介导心肌缺血再灌注损伤。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-11 DOI: 10.1007/s12265-025-10628-9

Yihua Wang, Qiang Yue, Xiurong Song, Wei Du, Rui Liu

{"title":"Hypoxia/reoxygenation-induced Glycolysis Mediates Myocardial Ischemia-reperfusion Injury Through Promoting the Lactylation of GPX4.","authors":"Yihua Wang, Qiang Yue, Xiurong Song, Wei Du, Rui Liu","doi":"10.1007/s12265-025-10628-9","DOIUrl":"https://doi.org/10.1007/s12265-025-10628-9","url":null,"abstract":"Myocardial ischemia-reperfusion injury (MIRI) is an injury mechanism of myocardial infarction, related to ferroptosis and glycolysis. Lactate produced by glycolysis promotes protein lactylation. This study aimed to investigate the correlation between glycolysis, ferroptosis, and GPX4 lactylation in MIRI. Hypoxia/reoxygenation (H/R) increased glucose uptake, lactate production, ECAR, OCR, LDH release, lipid ROS, Fe2+, GSH, MDA contents, and cell apoptosis, and decreased GSH level in the H9C2 cells, suggesting H/R promoted glycolysis and ferroptosis. 2-DG treatment relieved the H/R-induced injury, while lactate treatment aggravated it. Besides, 2-DG suppressed lactylation of GPX4 at K218 and K228 sites and increased its protein stability. GPX4 overexpression relieved the injury caused by H/R, and alleviated cardiac injury, decreased cardiomyocyte ferroptosis in heart tissues of MIRI rats. In conclusion, GPX4 lactylation facilitated H/R-induced cardiomyocyte injury and aggravated MIRI in rats. Our findings provided new insight into targeting glycolysis and GPX4 lactylation as therapeutic strategies of MIRI.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling the Hemodynamic Impact of Y-incision Aortic Annular Enlargements on Aortic Valve Replacement and Valve-in-Valve Procedures. y型切口主动脉环扩大对主动脉瓣置换术和瓣内手术的血流动力学影响建模。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-11 DOI: 10.1007/s12265-025-10634-x

Mia Bonini, Surya Sanjay, Maximilian Balmus, Alexander Makkinejad, Katelyn Monaghan, Marc Hirschvogel, Nicholas Burris, Bo Yang, David Nordsletten

引用次数: 0

Redesign of Implantable Cardiac Device Workflow Improves Remote Monitoring Timeliness and Heart Failure Alert Metrics. 重新设计植入式心脏装置工作流程提高远程监测及时性和心力衰竭警报指标。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-06 DOI: 10.1007/s12265-025-10632-z

Craig M Stolen, Molly E Kupfer, Karen Tomes, Sean Horan, Ananta Pandey, Julie Snodie, Kate Frost, Shawn Merhaut

{"title":"Redesign of Implantable Cardiac Device Workflow Improves Remote Monitoring Timeliness and Heart Failure Alert Metrics.","authors":"Craig M Stolen, Molly E Kupfer, Karen Tomes, Sean Horan, Ananta Pandey, Julie Snodie, Kate Frost, Shawn Merhaut","doi":"10.1007/s12265-025-10632-z","DOIUrl":"https://doi.org/10.1007/s12265-025-10632-z","url":null,"abstract":"Integration into clinical workflow remains a barrier to realizing the benefits of remote heart failure monitoring technologies. A workflow redesign program was conducted at 27 cardiology sites to improve implementation of heart failure remote monitoring with HeartLogic. Device data was retrospectively retrieved from HeartLogic-capable ICDs and CRT-Ds for the 12-month periods before and after re-design. Workflow redesign led to a decrease in HeartLogic enablement time (28±110 to 10±31 days, p<0.0001) and reduction in delayed data transmissions (10% to 6%). The number of HeartLogic alert onsets per year was unchanged; however, the length of individual alerts decreased from pre- to post-redesign (47.6±38.4 to 44.1±36.5 days, p=0.001) as did the percentage of time patients spent in alert (15.5±19.9% to 14.3±19.0%, p=0.04). The maximum HeartLogic index values per alert were also lower post-redesign (28.9±12.8 vs 27.8±12.1, p=0.001). Workflow redesign improved remote monitoring utilization and heart failure alert metrics.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exercise Empowerment: A Multifaceted Anatomy in Managing Diabetic Myocardial Disorder. 运动授权：管理糖尿病心肌疾病的多方面解剖。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-04 DOI: 10.1007/s12265-025-10630-1

Congfei Chen, Longfei Xu, Kun Wang, Tianhui Wang

{"title":"Exercise Empowerment: A Multifaceted Anatomy in Managing Diabetic Myocardial Disorder.","authors":"Congfei Chen, Longfei Xu, Kun Wang, Tianhui Wang","doi":"10.1007/s12265-025-10630-1","DOIUrl":"https://doi.org/10.1007/s12265-025-10630-1","url":null,"abstract":"Diabetic myocardial disorder is characterized by myocardial dysfunction in diabetes mellitus patients, independent of other heart disease causes like coronary artery disease or hypertension. This condition threatens the well-being of patients. At the cellular and molecular levels, disruptions in cardiomyocyte metabolism, abnormal calcium signaling, and increased reactive oxygen species production, among others, interconnect to create a complex pathological network that worsens myocardial cell damage and leads to cardiac dysfunction symptoms. The limited effectiveness of current pharmacological treatments has increased the appeal of non-pharmacological therapies, especially exercise therapy. Exercise is anticipated to ameliorate diabetic myocardial disease through pleiotropic beneficial effects. The fundamental mechanisms behind these benefits remain unclear; further investigation of these mechanisms will aid in developing targeted therapies. This paper aims to explore how exercise affects myocardial metabolism, antioxidant capacity, fibrosis, and microangiopathy while providing an overview of key mechanisms and recent breakthroughs to encourage ongoing research in this area.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosomal miR-320c: A Novel Biomarker for Atrial Cardiomyopathy. 外泌体miR-320c：心房心肌病的新生物标志物

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-04 DOI: 10.1007/s12265-025-10627-w

Yangcheng Xue, Zhuoran Jia, Shichu Liang, Manyu Dai, Fang Liu, Jian Wu, Ren Zhao

引用次数: 0

Cardiac Magnetic Resonance-Derived Left Ventricular Mechanical Dispersion Improves Risk Stratification of Hypertrophic Cardiomyopathy and its Correlations with Scar Heterogeneity. 心脏磁共振衍生的左心室机械离散度改善肥厚性心肌病的风险分层及其与疤痕异质性的相关性。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-02 DOI: 10.1007/s12265-025-10631-0

Xiaoying Zhao, Yujiao Song, Li Zhang, Lujing Wang, Xinxiang Zhao, Jin Wang

{"title":"Cardiac Magnetic Resonance-Derived Left Ventricular Mechanical Dispersion Improves Risk Stratification of Hypertrophic Cardiomyopathy and its Correlations with Scar Heterogeneity.","authors":"Xiaoying Zhao, Yujiao Song, Li Zhang, Lujing Wang, Xinxiang Zhao, Jin Wang","doi":"10.1007/s12265-025-10631-0","DOIUrl":"https://doi.org/10.1007/s12265-025-10631-0","url":null,"abstract":"The accuracy of prevalent risk models recommended by American Heart Association/American College of Cardiology(AHA/ACC) and European Society of Cardiology(ESC) for hypertrophic cardiomyopathy(HCM) patients is suboptimal. We assessed the utility of cardiac magnetic resonance(CMR)-3D left ventricular mechanical dispersion(LVMD) in the prognostic stratification of 159 HCM and explore the correlation with myocardial fibrosis heterogeneity. Entropy demonstrated linear correlations with 3D LVMD. Patients experienced endpoint events exhibited significantly higher radial LVMD(LVMD-R), circumferential LVMD(LVMD-C), and longitudinal LVMD(LVMD-L). Kaplan-Meier analyses demonstrated that HCM patients with elevated LVMD had a higher risk of primary and secondary endpoint events. In multivariable Cox analysis incorporated the guidelines risk classification, both LVMD-C and LVMD-L emerged as significant predictors for endpoint events. We developed a model incorporated the 2022 ESC risk stratification in combination with LVMD-C and LVMD-L and revealed that combined model significantly outperformed the guidelines alone. Additionally, entropy demonstrated linear correlations with LVMD.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endothelial Glycocalyx Damage and Restoration Following Vascular Stent Implantation. 血管支架植入术后内皮糖萼损伤与修复。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-02 DOI: 10.1007/s12265-025-10633-y

Belay Tesfamariam

{"title":"Endothelial Glycocalyx Damage and Restoration Following Vascular Stent Implantation.","authors":"Belay Tesfamariam","doi":"10.1007/s12265-025-10633-y","DOIUrl":"https://doi.org/10.1007/s12265-025-10633-y","url":null,"abstract":"The endothelial glycocalyx layer forms interface between the luminal surface and circulating blood, and consists of cell surface membrane-bound glycosaminoglycan chains and transmembrane embedded glycoproteins and proteoglycans, such as glypicans and syndecans. This dynamic layer contributes to various endothelial functions, including maintenance of vascular permeability, mechanosensation, shear-stress-mediated nitric oxide generation, modulation of interactions with constituents of blood, and regulation of vascular tone. Following vascular device placement, the transmembrane-linked glycosaminoglycan side chains are damaged and released into the circulation as soluble heparan sulfate, hyaluronan, and chondroitin sulfate. Damage to the glycocalyx causes an increase in vascular permeability, adhesion of leukocytes and platelets to the endothelium, extravasation of proinflammatory cells, dysregulation of vascular tone, imbalance of coagulation, and loss of antioxidant defense mechanisms. This review highlights the function of the endothelial glycocalyx as a vasoprotective layer and discusses targeted therapeutic approaches to promoting the restoration of glycocalyx disrupted by vascular stent implantation.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular Vesicles as Diagnostic Metrics for Cardiovascular Disease: Where We are and How to Achieve in Clinics. 细胞外囊泡作为心血管疾病的诊断指标：我们在哪里以及如何在临床中实现。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-02 DOI: 10.1007/s12265-025-10629-8

Yujia Wang, Yingxue Yuan, Junnan Tang

引用次数: 0

Targeting KDM4C Prevents Heart Failure after Acute Myocardial Infarction Via Activation of SOS2. 靶向KDM4C通过激活SOS2预防急性心肌梗死后心力衰竭

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-01 Epub Date: 2025-02-03 DOI: 10.1007/s12265-025-10594-2

Caiping Tan, Xiaoqi Chen, Lingqi Xu, Jiaping Chen, Yingbing Tu

引用次数: 0