Journal of Cardiovascular Translational Research最新文献_第3页

IL-22 Attenuates Pressure Overload-Induced Heart Failure and Inflammation. IL-22减轻压力过载引起的心力衰竭和炎症。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-04-07 DOI: 10.1007/s12265-025-10613-2

Lanqing Xiang, Guoqing Yin, Zifan Gong, Xian Lv, Cailin Feng, Lu Liu, Fuad A Abdu, Tingting Shi, Wen Zhang, Jiasuer Alifu, Xiaojiang Xu, Yuxiang Dai, Wenliang Che, Xinyu Weng

引用次数: 0

Association Between Magnesium Depletion Score and Peripheral Artery Disease in Middle-Aged and Older Population. 中老年人群镁耗尽评分与外周动脉疾病的关系

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-04-07 DOI: 10.1007/s12265-025-10615-0

Zongao Cai, Jiachen She

引用次数: 0

CRISPR-Cas9 Targeting PCSK9: A Promising Therapeutic Approach for Atherosclerosis. 靶向PCSK9的CRISPR-Cas9：一种有希望的动脉粥样硬化治疗方法

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-04-01 Epub Date: 2025-01-13 DOI: 10.1007/s12265-024-10587-7

Bin Gu, Min Li, Dan Li, Kaisen Huang

引用次数: 0

Drp1 Promotes Macrophage M1 Polarization and Inflammatory Response in Autoimmune Myocarditis by Driving Mitochondrial Fission. Drp1 通过驱动线粒体分裂促进自身免疫性心肌炎中巨噬细胞 M1 的极化和炎症反应

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-04-01 Epub Date: 2024-10-10 DOI: 10.1007/s12265-024-10570-2

Lin Lin, Jin Wei, Jiahong Xue, Gang Fan, Wenjing Zhu, Yanhe Zhu, Ruiyun Wu

{"title":"Drp1 Promotes Macrophage M1 Polarization and Inflammatory Response in Autoimmune Myocarditis by Driving Mitochondrial Fission.","authors":"Lin Lin, Jin Wei, Jiahong Xue, Gang Fan, Wenjing Zhu, Yanhe Zhu, Ruiyun Wu","doi":"10.1007/s12265-024-10570-2","DOIUrl":"10.1007/s12265-024-10570-2","url":null,"abstract":"Autoimmune myocarditis (AM) is characterized by an intricate inflammatory response within the myocardium. Dynamin-related protein 1 (Drp1), a pivotal modulator of mitochondrial fission, plays a role in the pathogenesis of various diseases. A myosin-induced experimental autoimmune myocarditis (EAM) mouse model was successfully established. Flow cytometry was employed to detect M1/M2-like macrophages. Mitochondrial fragmentation was assessed using Mito-Tracker Red CMXRos. Drp1 was upregulated and activated in EAM mice. Depletion of Drp1 was observed to mitigate inflammation, macrophage infiltration and M1 polarization within the cardiac tissue of EAM mice. In M1-like macrophages derived from the hearts of EAM mice, Drp1 was found to promote mitochondrial fission and diminish mitochondrial fusion. Furthermore, the depletion of Drp1 reduced the NF-κB-related pro-inflammatory response in EAM-associated M1-like macrophages. Drp1 drives mitochondrial fission in macrophages, driving their M1 polarization and the subsequent inflammatory response. Drp1 may represent an effective target for the prevention and treatment of AM.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"237-246"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic Value and Short-Term Prognosis Assessment of Copeptin in Non-ST-Elevation Acute Coronary Syndrome. Copeptin在非st段抬高急性冠脉综合征中的诊断价值及短期预后评价。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-04-01 Epub Date: 2024-12-28 DOI: 10.1007/s12265-024-10584-w

Facai Cui, Xueliang Pei, Mingzhi Ling, Fengxia Guo

引用次数: 0

Mechanical and Geometric Characterization of a Novel 2-Ply Vacuum-Pressed Biological Scaffold Patch Design for Posterior Mitral Valve Reconstruction. 用于二尖瓣后瓣重建的新型双层真空压制生物支架补片设计的机械和几何特性。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-04-01 Epub Date: 2024-10-28 DOI: 10.1007/s12265-024-10572-0

Johannes H Jedrzejczyk, Frederik T Andersen, Jacob Petersen, Alexander Emil Kaspersen, Urjosee Sahana, Søren N Skov, Jens T Væsel, J Michael Hasenkam, Marcell J Tjørnild

{"title":"Mechanical and Geometric Characterization of a Novel 2-Ply Vacuum-Pressed Biological Scaffold Patch Design for Posterior Mitral Valve Reconstruction.","authors":"Johannes H Jedrzejczyk, Frederik T Andersen, Jacob Petersen, Alexander Emil Kaspersen, Urjosee Sahana, Søren N Skov, Jens T Væsel, J Michael Hasenkam, Marcell J Tjørnild","doi":"10.1007/s12265-024-10572-0","DOIUrl":"10.1007/s12265-024-10572-0","url":null,"abstract":"To assess the mechanical properties of small intestinal submucosal extracellular matrix (SIS-ECM) iterations and choose the optimal version for evaluating functional geometrics after posterior mitral valve reconstruction. Four SIS-ECM versions (2- and 4-ply vacuum-pressed and lyophilized) underwent uniaxial tensile testing. A posterior mitral valve reconstruction patch was developed based on MRI scans (n = 5). Posterior mitral valve reconstruction using 2-ply vacuum-pressed SIS-ECM was performed (n = 7), and geometrics were evaluated using a modified left heart simulator. The vacuum-pressed iterations displayed superior maximum stress values compared to lyophilized (2-ply: median [IQR], 15.8 [15.2-19.0] vs 7.9 [7.3-8.3] MPa, p < 0.001; 4-ply: median (IQR), 15.8 -[14.6-22.0] vs 7.9 [7.6-8.4] MPa). All reconstructed valves were competent with preserved total leaflet area, but individual leaflet segment areas were redistributed. Posterior mitral valve reconstruction with our 2-ply vacuum-pressed SIS-ECM patch design was feasible in vitro. Further in vivo evaluation is warranted.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"268-279"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

p16^INK4a Aggravated Sepsis-associated Cardiac Injury by Inhibiting the PI3K/AKT Pathway and Inducing Redox Imbalance. p16INK4a通过抑制PI3K/AKT通路和诱导氧化还原失衡加重败血症相关的心脏损伤。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-04-01 Epub Date: 2025-01-14 DOI: 10.1007/s12265-024-10588-6

Baihong Li, Kai Wang, Xiaoyan Wang, Zhixuan Zhang, Guangyi Huang, Yiyi Ma, Yingqiang Du, Xin Gu, Jie Hui

引用次数: 0

Machine Learning Model for Risk Prediction of Prolonged Intensive Care Unit in Patients Receiving Intra-aortic Balloon Pump Therapy during Coronary Artery Bypass Graft Surgery. 机器学习模型在冠状动脉搭桥术中接受主动脉内球囊泵治疗的患者延长重症监护病房的风险预测。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-04-01 Epub Date: 2024-12-24 DOI: 10.1007/s12265-024-10580-0

Changqing Yang, Peng Zheng, Qian Zhang, Luo Li, Yajun Zhang, Quanye Li, Sheng Zhao, Zhan Shi

{"title":"Machine Learning Model for Risk Prediction of Prolonged Intensive Care Unit in Patients Receiving Intra-aortic Balloon Pump Therapy during Coronary Artery Bypass Graft Surgery.","authors":"Changqing Yang, Peng Zheng, Qian Zhang, Luo Li, Yajun Zhang, Quanye Li, Sheng Zhao, Zhan Shi","doi":"10.1007/s12265-024-10580-0","DOIUrl":"10.1007/s12265-024-10580-0","url":null,"abstract":"This study aimed to construct machine learning models and predict prolonged intensive care units (ICU) stay in patients receiving perioperative intra-aortic balloon pump (IABP) therapy during cardiac surgery. 236 patients were divided into the normal (≤ 14 days) and prolonged (> 14 days) ICU groups based on the 75th percentile of ICU duration across the entire cohort. Seven machine learning models were trained and validated. The Shapley Additive explanations (SHAP) method was employed to illustrate the effects of the features. 94 patients (39.83%) experienced prolonged ICU stay. The XGBoost model outperformed other models in predictive performance, as evidenced by its highest area under the receiver operating characteristic curve (training: 0.92; validation: 0.73). The SHAP analysis identified tracheotomy, albumin, Sv1, and cardiac troponin T as the top four risk variables. The XGBoost model predicted risk variables for prolonged ICU stay in patients, possibly contributing to improving perioperative management and reducing ICU duration.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"341-353"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and Internal Validation of an AI-Enabled Cuff-less, Non-invasive Continuous Blood Pressure Monitor Across All Classes of Hypertension. 开发并在内部验证人工智能无袖带无创连续血压监测仪，适用于所有类型的高血压。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-04-01 Epub Date: 2025-01-13 DOI: 10.1007/s12265-024-10589-5

Francisco Lopez-Jimenez, Abhishek Deshmukh, John Bisognano, John Boehmer, Mouli Ramasamy, Prashanth Shyam Kumar, Suraj Kapa, Venk Varadan, Vijay Varadan, Marat Fudim

{"title":"Development and Internal Validation of an AI-Enabled Cuff-less, Non-invasive Continuous Blood Pressure Monitor Across All Classes of Hypertension.","authors":"Francisco Lopez-Jimenez, Abhishek Deshmukh, John Bisognano, John Boehmer, Mouli Ramasamy, Prashanth Shyam Kumar, Suraj Kapa, Venk Varadan, Vijay Varadan, Marat Fudim","doi":"10.1007/s12265-024-10589-5","DOIUrl":"10.1007/s12265-024-10589-5","url":null,"abstract":"Background: Non-invasive, continuous blood pressure monitoring technologies require additional validation beyond standard cuff-based methods. This study evaluates a non-invasive, multiparametric wearable cuffless blood pressure (BP) diagnostic monitor across all hypertension classes with diverse subjects.Methods: A prospective, multicenter study assessed Nanowear's SimpleSense-BP performance, including induced and natural BP changes, significant BP variations (Systolic BP (SBP) ≥ ± 15 mm Hg and Diastolic BP (DBP) ≥ ± 10 mm Hg), and reference input value validity over 4 weeks.Results: 303 subjects (18-83 yrs; 50.16% Female) participated in algorithmic development and validation (Normal - 35%, Prehypertensive - 24%, Stage 1 - 24%, Stage 2 - 17%). 54 subjects were tested for induced change performance, 149 exhibited significant changes, and 91 validated reference value duration.Conclusions: The study clinically validated a continuous, AI-based BP diagnostic monitor using non-invasive wearable data. Further testing on diverse populations and external validation are recommended. The protocol was inspired by ISO 81060-2 and IEEE 1708:2019 standards.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"280-290"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mesenchymal Stem Cell-based Apelin Gene Therapy Improves Pulmonary Artery Remodeling in Monocrotaline-induced Pulmonary Hypertension Through PI3K/AKT/eNOS and ERK1/2 Signaling Pathways. 基于间充质干细胞的Apelin基因治疗通过PI3K/AKT/eNOS和ERK1/2信号通路改善单芥碱诱导的肺动脉高压的肺动脉重塑

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-04-01 DOI: 10.1007/s12265-025-10612-3

Li Wang, Weijian Wang, Ting Wu, Liang Chen, Gangjun Zong

{"title":"Mesenchymal Stem Cell-based Apelin Gene Therapy Improves Pulmonary Artery Remodeling in Monocrotaline-induced Pulmonary Hypertension Through PI3K/AKT/eNOS and ERK1/2 Signaling Pathways.","authors":"Li Wang, Weijian Wang, Ting Wu, Liang Chen, Gangjun Zong","doi":"10.1007/s12265-025-10612-3","DOIUrl":"https://doi.org/10.1007/s12265-025-10612-3","url":null,"abstract":"Pulmonary arterial hypertension (PAH) poses a challenge due to limited curative options and ineffective treatments. Mesenchymal stem cell (MSC) therapy has emerged as a potential intervention for PAH. This study delved into the therapeutic potential and molecular mechanisms underlying MSC-based apelin gene therapy in PAH rats induced by monocrotaline (MCT). Wharton's jelly-derived MSCs transfected with pcSLenti-APLN were utilized as therapeutic agents. Transplanted MSCs successfully homed to the lung tissue of rats and sustained survival for at least three weeks. MSC-mediated apelin gene therapy effectively reduced pulmonary artery pressure, mitigated pulmonary vascular remodeling, and modulated apoptosis in MCT-induced PAH rats. Furthermore, the phosphatidylinositol 3-kinase (PI3K)/AKT/endothelial nitric oxide synthase (eNOS) and ERK1/2 signaling pathways were involved in the therapeutic effects. Meanwhile, Apelin-MSCs also regulated MCT-induced changes of Bax and Bcl-2 in the lung lobes and pulmonary arterioles. MSC-based apelin gene therapy could be considered a possible therapeutic strategy for PAH.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0