Journal of Cardiovascular Translational Research最新文献_第3页

Force Analysis Using Self-Expandable Valve Fluoroscopic Imaging: a way Through Artificial Intelligence. 利用自膨胀瓣膜透视成像进行受力分析：一种通过人工智能的方法。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-12-01 Epub Date: 2024-08-01 DOI: 10.1007/s12265-024-10550-6

Yiming Qi, Xiaochun Zhang, Zhiyun Shen, Yixiu Liang, Shasha Chen, Wenzhi Pan, Daxin Zhou, Junbo Ge

引用次数: 0

Adaptation of Aortic Bioprosthetic Valves for Pulmonary Position: Comparative Analysis of Transcatheter and Surgical Valves. 适应肺部位置的主动脉生物人工瓣膜：经导管瓣膜与手术瓣膜的比较分析。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-12-01 Epub Date: 2024-10-18 DOI: 10.1007/s12265-024-10528-4

Mina Shafiei, Dong Qiu, Ali N Azadani

{"title":"Adaptation of Aortic Bioprosthetic Valves for Pulmonary Position: Comparative Analysis of Transcatheter and Surgical Valves.","authors":"Mina Shafiei, Dong Qiu, Ali N Azadani","doi":"10.1007/s12265-024-10528-4","DOIUrl":"10.1007/s12265-024-10528-4","url":null,"abstract":"Pulmonary valve dysfunction is common in congenital heart disease, often leading to interventions like right ventricular outflow tract reconstruction. Transcatheter pulmonary valve replacement (TPVR) has emerged as a successful alternative to surgery, showcasing promising outcomes for managing postoperative RVOT complications. The study aimed to compare two bioprosthetic valves-Carpentier Edwards Perimount Magna Ease surgical valve and Edwards SAPIEN 3 transcatheter valve-originally designed for aortic use but adapted for pulmonary applications. The hemodynamic characteristics of a 26-mm SAPIEN 3 and a 25-mm Magna Ease were assessed in a pulse duplicator under both pulmonary and aortic conditions. Furthermore, detailed structural analyses of the leaflets were conducted using computational simulations under these conditions. The results highlighted significant differences in the hydrodynamic and structural characteristics of these two bioprosthetic valves when exposed to pulmonary versus aortic conditions. The study enhances our understanding of the biomechanics involved in surgical and transcatheter pulmonary valve replacement.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"1338-1346"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive Quality Analysis of Conventional and Novel Biomarkers in Diagnosing and Predicting Prognosis of Coronary Artery Disease, Acute Coronary Syndrome, and Heart Failure, a Comprehensive Literature Review. 用于诊断和预测冠心病、急性冠脉综合征和心力衰竭预后的传统和新型生物标记物的综合质量分析，全面文献综述。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-12-01 Epub Date: 2024-07-12 DOI: 10.1007/s12265-024-10540-8

Muhammad Abubakar, Umema Irfan, Ahmad Abdelkhalek, Izzah Javed, Muhammad Imran Khokhar, Fraz Shakil, Saud Raza, Siffat Saima Salim, Muhammad Mahran Altaf, Rizwan Habib, Simra Ahmed, Farea Ahmed

{"title":"Comprehensive Quality Analysis of Conventional and Novel Biomarkers in Diagnosing and Predicting Prognosis of Coronary Artery Disease, Acute Coronary Syndrome, and Heart Failure, a Comprehensive Literature Review.","authors":"Muhammad Abubakar, Umema Irfan, Ahmad Abdelkhalek, Izzah Javed, Muhammad Imran Khokhar, Fraz Shakil, Saud Raza, Siffat Saima Salim, Muhammad Mahran Altaf, Rizwan Habib, Simra Ahmed, Farea Ahmed","doi":"10.1007/s12265-024-10540-8","DOIUrl":"10.1007/s12265-024-10540-8","url":null,"abstract":"Coronary artery disease (CAD), acute coronary syndrome (ACS), and heart failure (HF) are major global health issues with high morbidity and mortality rates. Biomarkers like cardiac troponins (cTn) and natriuretic peptides (NPs) are crucial tools in cardiology, but numerous new biomarkers have emerged, proving increasingly valuable in CAD/ACS. These biomarkers are classified based on their mechanisms, such as fibrosis, metabolism, inflammation, and congestion. The integration of established and emerging biomarkers into clinical practice is an ongoing process, and recognizing their strengths and limitations is crucial for their accurate interpretation, incorporation into clinical settings, and improved management of CVD patients. We explored established biomarkers like cTn, NPs, and CRP, alongside newer biomarkers such as Apo-A1, IL-17E, IgA, Gal-3, sST2, GDF-15, MPO, H-FABP, Lp-PLA2, and ncRNAs; provided evidence of their utility in CAD/ACS diagnosis and prognosis; and empowered clinicians to confidently integrate these biomarkers into clinical practice based on solid evidence.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"1258-1285"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141590428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Genetic Variants Associated with Primary Myocardial Fibrosis in Sudden Cardiac Death Victims. 与心脏性猝死患者原发性心肌纤维化有关的新型基因变异。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-12-01 Epub Date: 2024-06-07 DOI: 10.1007/s12265-024-10527-5

Sini Skarp, Anne Doedens, Lauri Holmström, Valerio Izzi, Samu Saarimäki, Eeva Sliz, Johannes Kettunen, Lasse Pakanen, Risto Kerkelä, Katri Pylkäs, Heikki V Huikuri, Robert J Myerburg, Juhani Junttila

{"title":"Novel Genetic Variants Associated with Primary Myocardial Fibrosis in Sudden Cardiac Death Victims.","authors":"Sini Skarp, Anne Doedens, Lauri Holmström, Valerio Izzi, Samu Saarimäki, Eeva Sliz, Johannes Kettunen, Lasse Pakanen, Risto Kerkelä, Katri Pylkäs, Heikki V Huikuri, Robert J Myerburg, Juhani Junttila","doi":"10.1007/s12265-024-10527-5","DOIUrl":"10.1007/s12265-024-10527-5","url":null,"abstract":"Myocardial fibrosis is a common finding in victims of sudden cardiac death (SCD). Whole exome sequencing was performed in 127 victims of SCD with primary myocardial fibrosis as the only pathological finding. These cases are derived from the Fingesture study which has collected data from autopsy-verified SCD victims in Northern Finland. A computational approach was used to identify protein interactions in cardiomyocytes. Associations of the identified variants with cardiac disease endpoints were investigated in the Finnish national genetic study (FinnGen) dataset. We identified 21 missense and one nonsense variant. Four variants were estimated to affect protein function, significantly associated with SCD/primary myocardial fibrosis (Fingesture) and associated with cardiac diseases in Finnish population (FinnGen). These variants locate in cartilage acidic protein 1 (CRATC1), calpain 1 (CAPN1), unc-45 myosin chaperone A (UNC45A) and unc-45 myosin chaperone B (UNC45B). The variants identified contribute to function of extracellular matrix and cardiomyocytes.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"1229-1239"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141283833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphological Features of the Vertebrobasilar System Predict Ischemic Stroke Risk in Spontaneous Vertebral Artery Dissection. 椎基底动脉系统的形态特征可预测自发性椎动脉夹层的缺血性中风风险

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-12-01 Epub Date: 2024-07-09 DOI: 10.1007/s12265-024-10534-6

Jiajia Bao, Mateng Bai, Muke Zhou, Jinghuan Fang, Yanbo Li, Jian Guo, Li He

{"title":"Morphological Features of the Vertebrobasilar System Predict Ischemic Stroke Risk in Spontaneous Vertebral Artery Dissection.","authors":"Jiajia Bao, Mateng Bai, Muke Zhou, Jinghuan Fang, Yanbo Li, Jian Guo, Li He","doi":"10.1007/s12265-024-10534-6","DOIUrl":"10.1007/s12265-024-10534-6","url":null,"abstract":"The vertebral artery's morphological characteristics are crucial in spontaneous vertebral artery dissection (sVAD). We aimed to investigate morphologic features related to ischemic stroke (IS) and develop a novel prediction model. Out of 126 patients, 93 were finally analyzed. We constructed 3D models and morphological analyses. Patients were randomly classified into training and validation cohorts (3:1 ratio). Variables selected by LASSO - including five morphological features and five clinical characteristics - were used to develop prediction model in the training cohort. The model exhibited a high area under the curve (AUC) of 0.944 (95%CI, 0.862-0.984), with internal validation confirming its consistency (AUC = 0.818, 95%CI, 0.597-0.948). Decision curve analysis (DCA) indicated clinical usefulness. Morphological features significantly contribute to risk stratification in sVAD patients. Our novel developed model, combining interdisciplinary parameters, is clinically useful for predicting IS risk. Further validation and in-depth research into the hemodynamics related to sVAD are necessary.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"1365-1376"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141558845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-intensity Focused Ultrasound-A New Choice to Conduct Pulmonary Artery Denervation. 高强度聚焦超声--进行肺动脉去神经支配的新选择

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-12-01 Epub Date: 2024-07-06 DOI: 10.1007/s12265-024-10531-9

Yonghui Xie, Taoyue Yao, Xiaogang Zhu, Fan Yang, Haoqin Fan, Shirui Cao, Huaiyang Chen, Manzhen Liao, Yuanxi Xia, Jinqiao Liu, Zhenghui Xiao, Zhou Yang, Yunbin Xiao

{"title":"High-intensity Focused Ultrasound-A New Choice to Conduct Pulmonary Artery Denervation.","authors":"Yonghui Xie, Taoyue Yao, Xiaogang Zhu, Fan Yang, Haoqin Fan, Shirui Cao, Huaiyang Chen, Manzhen Liao, Yuanxi Xia, Jinqiao Liu, Zhenghui Xiao, Zhou Yang, Yunbin Xiao","doi":"10.1007/s12265-024-10531-9","DOIUrl":"10.1007/s12265-024-10531-9","url":null,"abstract":"This research aimed to explore whether high-intensity focused ultrasound (HIFU) could conduct pulmonary artery denervation (PADN). HIFU was performed in pulmonary arteries of 6 normotensive rabbits at dose of 250W, 6 times for each rabbit, and an additional 6 rabbits served as controls. Then ATEPH was induced in both groups by intravenous infusion of autogeneic thrombus. Hemodynamics and ultrasonography parameters were measured by right heart catheter and echocardiography pre- and post-establishment of ATEPH models in both groups. Histological analysis and immunohistochemistry of tyrosine hydroxylase (TH) were also performed. After PADN procedures, 5 rabbits were successfully conducted PADN, of which ablation zone was also observed in right auricle or right lung in 4 rabbits. Ablation zone was detected only in right lung in 1 rabbit. Compared with control group, milder right heart hemodynamic changes were found in PADN group, accompanied by improved ultrasound parameters in PADN group. HIFU can acutly damage SNs around pulmonary artery successfully, which may be a new choice to conduct PADN. However, the accuracy of HIFU with PADN needs to be improved.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"1353-1364"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11635049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141544876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasma Biomarker Screening Based on Proteomic Signature of Patients with Resistant Hypertension. 基于难治性高血压患者蛋白质组特征的血浆生物标志物筛查

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-12-01 Epub Date: 2024-07-06 DOI: 10.1007/s12265-024-10541-7

Jianmin Du, Xiaoqian Yu, Wenyu Zhang, Xinghai Zhang, Hengli Zhao, Rui Xu, Qing Wen

引用次数: 0

Adult Cardiomyocyte-Derived Extracellular Vesicles: a Promising Therapy for Cardiac Fibrosis. 成人心肌细胞衍生的细胞外囊泡：一种治疗心脏纤维化的有效疗法

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-12-01 Epub Date: 2024-08-26 DOI: 10.1007/s12265-024-10554-2

Hongyun Wang, Xinpeng Li, Qianwen Wu, Wei Chen, Yihua Bei

引用次数: 0

Hyperspectral Imaging for Microcirculatory Assessment of Patients undergoing Transcatheter and Surgical Aortic Valve Replacement-a Prospective Observational Pilot Study. 用于经导管主动脉瓣置换术和外科主动脉瓣置换术患者微循环评估的高光谱成像--一项前瞻性观察试点研究。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-11-08 DOI: 10.1007/s12265-024-10573-z

Maximilian Dietrich, Aycan Tayan, Tobias Hölle, Christian Nusshag, Anne-Christine Kapp, Christina Mertens, Alexander Studier-Fischer, Felix Nickel, Florian Leuschner, Markus Alexander Weigand, Matthias Karck, Christoph Lichtenstern, Rawa Arif, Dania Fischer

{"title":"Hyperspectral Imaging for Microcirculatory Assessment of Patients undergoing Transcatheter and Surgical Aortic Valve Replacement-a Prospective Observational Pilot Study.","authors":"Maximilian Dietrich, Aycan Tayan, Tobias Hölle, Christian Nusshag, Anne-Christine Kapp, Christina Mertens, Alexander Studier-Fischer, Felix Nickel, Florian Leuschner, Markus Alexander Weigand, Matthias Karck, Christoph Lichtenstern, Rawa Arif, Dania Fischer","doi":"10.1007/s12265-024-10573-z","DOIUrl":"https://doi.org/10.1007/s12265-024-10573-z","url":null,"abstract":"This prospective, observational study evaluated Hyperspectral Imaging (HSI) to assess the effects of cardiac surgery and cardiopulmonary bypass (CPB) on microcirculation. 40 Patients with severe aortic stenosis were enrolled. 20 patients underwent transapical/transaxillary/transaortic aortic valve replacement (TAVR), 20 underwent an open surgical approach with CPB (SAVR). HSI was used to determine tissue oxygenation (StO2 and NIR), hemoglobin (THI) and water content (TWI) at the palm before/after surgery (T1/T2), and on the third postoperative day (T3). TAVR patients showed no significant changes of microcirculatory parameters during surgery. TWI significantly increased until T3. SAVR patients showed an increase of TWI and a decrease of THI, while StO2 and NIR remained unchanged at T2. In SAVR patients, StO2 and NIR correlated negatively with the duration of CPB and StO2 correlated with intraoperative urine output at T2. HSI was able to detect microcirculatory changes during cardiac surgery. CPB duration seemed to affect tissue oxygenation. Clinical trial registration: (German Clinical Trial Register): DRKS00024765.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

β-Hydroxybutyrate and Citrate Synthase as Potential Diagnostic Biomarkers in Aging-Related Atrial Fibrillation. β-羟丁酸和柠檬酸合成酶作为衰老相关心房颤动的潜在诊断生物标志物

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-11-05 DOI: 10.1007/s12265-024-10569-9

Jia-Kang He, Xiao-Xiao Jiang, Shi-Yu Dai, Xiao-Han, Qian-Qiu Zhu, Jie-Yang, Yun-Long Zhang, Xiao-Hong Yu

{"title":"β-Hydroxybutyrate and Citrate Synthase as Potential Diagnostic Biomarkers in Aging-Related Atrial Fibrillation.","authors":"Jia-Kang He, Xiao-Xiao Jiang, Shi-Yu Dai, Xiao-Han, Qian-Qiu Zhu, Jie-Yang, Yun-Long Zhang, Xiao-Hong Yu","doi":"10.1007/s12265-024-10569-9","DOIUrl":"https://doi.org/10.1007/s12265-024-10569-9","url":null,"abstract":"The incidence of atrial fibrillation (AF) increases with age; however, the precise mechanisms by which aging elevates AF risk and the effective biomarkers for managing AF in elderly patients remain unclear. We analyzed plasma samples from 100 elderly AF patients, 100 young and 100 elderly patients without atrial fibrillation (NAF), along with left atrial tissues obtained from both AF and NAF patients following valve replacement. Our findings indicate reduced levels of β-OHB and citrate synthase (CS) activity in elderly AF patients compared to their NAF counterparts. Statistical analysis revealed a protective association between β-OHB and CS activity concerning the occurrence of elderly AF. Furthermore, atrial tissues from elderly AF patients exhibited mitochondrial dysfunction, structural remodeling, and low-voltage areas. These results suggest that dysregulation of β-OHB levels and CS activity may contribute to aging-related AF by affecting mitochondrial function and atrial remodeling, highlighting their potential as diagnostic biomarkers for this condition.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0