Journal of Cardiovascular Translational Research最新文献_第3页

Associations of Endothelial-Related lncRNAs with Early-Onset STEMI: A Case-Control Study. 内皮相关lncrna与早发性STEMI的关联：一项病例对照研究

IF 2.5 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2026-02-27 DOI: 10.1007/s12265-026-10745-z

Elham Madandar, Yasaman Zarinfar, Mohammad Hassan Namazi, Nasim Sohrabifar, Mohammad Javad Namazi, Vahid Eslami, Isa Khaheshi

引用次数: 0

Ultrasound-Guided Percutaneous Puncture to Establish a Rat Model of Mitral Regurgitation: A Non-Thoracotomy Approach. 超声引导下经皮穿刺建立大鼠二尖瓣反流模型：非开胸入路。

IF 2.5 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2026-02-25 DOI: 10.1007/s12265-026-10758-8

Kangla Liao, Qian Dong, Chunhua Mo, Guoli Yang, Bi Huang, Suxin Luo

{"title":"Ultrasound-Guided Percutaneous Puncture to Establish a Rat Model of Mitral Regurgitation: A Non-Thoracotomy Approach.","authors":"Kangla Liao, Qian Dong, Chunhua Mo, Guoli Yang, Bi Huang, Suxin Luo","doi":"10.1007/s12265-026-10758-8","DOIUrl":"https://doi.org/10.1007/s12265-026-10758-8","url":null,"abstract":"Mitral regurgitation (MR) is a significant risk factor for heart failure, yet existing rodent models face limitations in invasiveness and reproducibility. This study established a novel percutaneous, ultrasound-guided rat model of MR to overcome these constraints. Thirty male Sprague-Dawley rats underwent echocardiography-guided mitral valve injury, allocated to severe MR (40-70% regurgitation), massive MR (> 70%), or sham groups. Serial echocardiographic assessments were performed at baseline, 30 min, and 2, 4, and 8 weeks post-procedure, with histological validation of myocardial fibrosis. The technique achieved 100% success with no acute mortality and enabled precise titration of regurgitation severity. Both MR groups exhibited progressive, body size-independent cardiac remodeling. Speckle-tracking revealed basal-segment-predominant longitudinal strain reduction, correlating with histologically confirmed peri-annular fibrosis. Survival was significantly lower in massive MR (40% vs. 90%, p = 0.006). This minimally invasive model reliably replicates human MR pathophysiology with high reproducibility and precise severity control, providing a robust platform for mechanistic investigation.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":"19 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147283830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lacylation of Stearoyl-CoA Desaturase-1 Contributes to the Myocardial Ischemia-Reperfusion Injury Through Regulating Wnt/β-Catenin Signaling. 脂酰辅酶a去饱和酶-1的酰化通过调节Wnt/β-Catenin信号通路参与心肌缺血-再灌注损伤

IF 2.5 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2026-02-22 DOI: 10.1007/s12265-026-10751-1

Ying Zhang, Junshi Zhang, Yaling Zhang, Lihua Sun

{"title":"Lacylation of Stearoyl-CoA Desaturase-1 Contributes to the Myocardial Ischemia-Reperfusion Injury Through Regulating Wnt/β-Catenin Signaling.","authors":"Ying Zhang, Junshi Zhang, Yaling Zhang, Lihua Sun","doi":"10.1007/s12265-026-10751-1","DOIUrl":"https://doi.org/10.1007/s12265-026-10751-1","url":null,"abstract":"Myocardial ischemia-reperfusion injury (MIRI) involves tissue damage following restoration of blood flow. Stearoyl-CoA desaturase 1 (SCD1), associated with metabolic disorders, may contribute to MIRI. This study investigated the mechanism of SCD1 in MIRI. A rat ischemia/reperfusion (I/R) model was established by ligating the left anterior descending coronary artery. The hypoxia/reoxygenation (H/R) model was used to simulate in vitro I/R. 2,3,5-triphenyltetrazolium chloride staining and immunohistochemistry were performed for histopathological analysis of rat heart tissues. The ferroptosis indicators were detected using commercial kits and Western blot. Lactylation and ubiquitination of SCD1 were detected by Western blot. I/R increased tissue damage and SCD1 expression. In addition, SCD1 inhibition attenuated ferroptosis in H/R cells and I/R hearts. H/R induced ferroptosis via promoting lactylation modification in H9c2 cells. Mechanistically, lactylation of SCD1 at K208 stabilized its protein stability and activated Wnt/β-Catenin signaling to promote ferroptosis in H9c2 cells. In vivo, SCD1 silencing inhibited the MIRI. SCD1 lactylation drove ferroptosis in MIRI by regulating Wnt/β-Catenin signaling, offering potential therapeutic insights.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":"19 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147270895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucagon-like Peptide-1 Receptor Dependent Signaling in Cardiovascular Health and Disease: A Mini-review. 胰高血糖素样肽-1受体依赖性信号在心血管健康和疾病中的作用：综述

IF 2.5 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2026-02-22 DOI: 10.1007/s12265-026-10759-7

Meng-Piao Lin, Bing-Jie Xue, Xiao-Jie Bai

引用次数: 0

Best Paper of the Year 2025. 2025年度最佳论文。

IF 2.5 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2026-02-21 DOI: 10.1007/s12265-026-10754-y

Enrique Lara-Pezzi

引用次数: 0

Endothelial SRSF1: A Key Regulator of Post-Ischemic Angiogenesis. 内皮细胞SRSF1：缺血后血管生成的关键调节因子。

IF 2.5 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2026-02-19 DOI: 10.1007/s12265-026-10750-2

Meiyu Hu, Shihui Zang, Yifu Chen, Tingting Yang, Junjie Xiao

引用次数: 0

Computational Fluid Dynamics Simulation of Endothelium-Modulated Thrombosis. 内皮调节性血栓形成的计算流体动力学模拟。

IF 2.5 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2026-02-18 DOI: 10.1007/s12265-026-10749-9

Wenxuan He, Abhishek Karmakar, James F Antaki

{"title":"Computational Fluid Dynamics Simulation of Endothelium-Modulated Thrombosis.","authors":"Wenxuan He, Abhishek Karmakar, James F Antaki","doi":"10.1007/s12265-026-10749-9","DOIUrl":"https://doi.org/10.1007/s12265-026-10749-9","url":null,"abstract":"The development of blood-wetted artificial organs is limited by thrombosis on synthetic biomaterial surfaces. In contrast, the endothelium of the vasculature creates a natural barrier to both thrombosis and pannus growth. Consequently, efforts have been made to endothelialize synthetic biomaterials used in blood-wetted devices. Therefore, this study was undertaken to provide a numerical model to simulate the inhibitory effects of EC-derived nitric oxide (NO) on platelet deposition. An existing multi-constituent continuum model of thrombosis was amended to incorporate shear-dependent generation of NO as an anticoagulant. A simulation was performed of blood flow through a bipartite parallel plate channel having an endothelialized upstream layer followed by a pro-coagulant collagen surface downstream. The simulation showed that endothelial-derived NO inhibited downstream platelet deposition, reducing thrombus growth and creating a thrombus-free zone immediately downstream. This enhanced simulation model of thrombosis provides insights into factors that may guide future endothelialization of artificial organs and other blood-wetted devices.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":"19 1","pages":"25"},"PeriodicalIF":2.5,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146220090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to the letter to the Editor: Comment on "A Potential Ratio for Detecting Subclinical Atherosclerosis: Insight into Advanced NMR Lipid Profiles in Severe Obesity". 回复给编辑的信：对“检测亚临床动脉粥样硬化的潜在比率：深入了解严重肥胖的高级核磁共振脂质谱”的评论。

IF 2.5 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2026-02-18 DOI: 10.1007/s12265-026-10746-y

Júlia Carmona-Maurici, Iratxe Eskubi-Turró, Eva Pardina

引用次数: 0

CD4⁺ Treg: A Novel Player in Cardiac Regenerative Therapy. CD4+ Treg：心脏再生治疗的新参与者

IF 2.5 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2026-02-18 DOI: 10.1007/s12265-026-10748-w

Meiyu Hu, Tingting Yang, Xinxiu Meng, Shuqin Liu, Junjie Xiao

引用次数: 0

Comment on "A Potential Ratio for Detecting Subclinical Atherosclerosis: Insight into Advanced NMR Lipid Profiles in Severe Obesity". 对“检测亚临床动脉粥样硬化的潜在比率：深入了解严重肥胖的高级核磁共振脂质谱”的评论。