Journal of Cardiovascular Translational Research最新文献_第4页

β-Hydroxybutyrate and Citrate Synthase as Potential Diagnostic Biomarkers in Aging-Related Atrial Fibrillation. β-羟丁酸和柠檬酸合成酶作为衰老相关心房颤动的潜在诊断生物标志物

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-02-01 Epub Date: 2024-11-05 DOI: 10.1007/s12265-024-10569-9

Jia-Kang He, Xiao-Xiao Jiang, Shi-Yu Dai, Xiao-Han, Qian-Qiu Zhu, Jie-Yang, Yun-Long Zhang, Xiao-Hong Yu

{"title":"β-Hydroxybutyrate and Citrate Synthase as Potential Diagnostic Biomarkers in Aging-Related Atrial Fibrillation.","authors":"Jia-Kang He, Xiao-Xiao Jiang, Shi-Yu Dai, Xiao-Han, Qian-Qiu Zhu, Jie-Yang, Yun-Long Zhang, Xiao-Hong Yu","doi":"10.1007/s12265-024-10569-9","DOIUrl":"10.1007/s12265-024-10569-9","url":null,"abstract":"The incidence of atrial fibrillation (AF) increases with age; however, the precise mechanisms by which aging elevates AF risk and the effective biomarkers for managing AF in elderly patients remain unclear. We analyzed plasma samples from 100 elderly AF patients, 100 young and 100 elderly patients without atrial fibrillation (NAF), along with left atrial tissues obtained from both AF and NAF patients following valve replacement. Our findings indicate reduced levels of β-OHB and citrate synthase (CS) activity in elderly AF patients compared to their NAF counterparts. Statistical analysis revealed a protective association between β-OHB and CS activity concerning the occurrence of elderly AF. Furthermore, atrial tissues from elderly AF patients exhibited mitochondrial dysfunction, structural remodeling, and low-voltage areas. These results suggest that dysregulation of β-OHB levels and CS activity may contribute to aging-related AF by affecting mitochondrial function and atrial remodeling, highlighting their potential as diagnostic biomarkers for this condition.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"133-145"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11885335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chitinase-3-like Protein 1 Reduces the Stability of Atherosclerotic Plaque via Impairing Macrophagic Efferocytosis. 几丁质酶-3样蛋白1通过损害巨噬细胞Efferocytosis降低动脉粥样硬化斑块的稳定性。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-02-01 Epub Date: 2025-01-15 DOI: 10.1007/s12265-024-10576-w

Yandong Liu, Weilin Hu, Futang Yang, Sili Zou, Huiqiong Ren, Yong Zuo, Lefeng Qu

{"title":"Chitinase-3-like Protein 1 Reduces the Stability of Atherosclerotic Plaque via Impairing Macrophagic Efferocytosis.","authors":"Yandong Liu, Weilin Hu, Futang Yang, Sili Zou, Huiqiong Ren, Yong Zuo, Lefeng Qu","doi":"10.1007/s12265-024-10576-w","DOIUrl":"10.1007/s12265-024-10576-w","url":null,"abstract":"CHI3L1 is strongly associated with atherosclerosis, but its role in macrophages remains unknown. In this study, we observed a significant up-regulation of CHI3L1 in both carotid plaques and serum of symptomatic patients, and demonstrated that CHI3L1 impairs the efferocytosis of macrophages by down-regulating crucial efferocytic mediator MFGE8 through inhibiting ATF2, which binds directly to the enhancer of MFGE8. In human plaques, we observed a negative correlation between CHI3L1 expression and both ATF2 and MFGE8 levels, further proved their involvement in plaque destabilization. Using Ldlr-/- mice with tandem carotid stenosis surgery, we demonstrated that administration of CHI3L1 protein resulted in enlarged atherosclerotic necrotic cores and decreased MFGE8 and ATF2 levels. Conversely, treatment with a CHI3L1 blocking antibody exhibited the opposite trend.In conclusion, CHI3L1 destabilizes atherosclerotic plaque by impairing macrophagic efferocytosis through the down-regulation of ATF2-induced MFGE8 expression. Targeting CHI3L1 may offer a promising therapeutic strategy for the treatment of atherosclerosis.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"3-16"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Induction of Controllable Vortical Flow in a Dual-Stenosis Aorta Model: A Replication of Disordered Eddies Flow in Aneurysms. 在双狭窄主动脉模型中诱导可控涡流：动脉瘤中无序涡流的再现。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-02-01 Epub Date: 2024-10-07 DOI: 10.1007/s12265-024-10566-y

Zhijie Wang, Zonghan Lyu, Jingfeng Jiang

{"title":"Induction of Controllable Vortical Flow in a Dual-Stenosis Aorta Model: A Replication of Disordered Eddies Flow in Aneurysms.","authors":"Zhijie Wang, Zonghan Lyu, Jingfeng Jiang","doi":"10.1007/s12265-024-10566-y","DOIUrl":"10.1007/s12265-024-10566-y","url":null,"abstract":"This paper presents a two-stenosis aorta model mimicking vortical flow in vascular aneurysms. More specifically, we propose to virtually induce two adjacent stenoses in the abdominal aorta to develop various vortical flow zones post stenoses. Computational fluid dynamics (CFD) simulations were conducted for the virtual two-stenosis model based on physiological and anatomical data (i.e., diameters, flow rate waveforms) from adult rabbits. The virtual model includes adult rabbits' infra-renal portion of the aorta and iliac arteries. 3D CFD simulations in five different dual-stenosis configurations were performed using a commercial CFD package (FLUENT). In-house software assessed the evolution of flow vortices. Notably, spatial-temporally averaged wall shear stress (STA-WSS) and oscillatory shear index (OSI), the total volume of vortex flow, the number of vortices, and the phase-to-phase overlap of vortex flow within each region were evaluated. In all models, we found consistent patterns of the vortex flow parameters, indicating that the adjacent stenoses induced three different hemodynamic zones, namely, stable vortical flow (after the first stenosis), transient vortical flow (after the second stenosis), and unstable vortical flow (further distal to the second stenosis). Also, different degrees of flow disturbance can be achieved in these three zones. It is significant to note that, although the 'dual-stenosis' geometry is completely hypothetical, it allows us to create various vortical flows in consecutive vessel segments for the first time. As a result, if implemented as a pre-clinical model, the proposed two-stenosis model offers an attractive, tunable environment to investigate the interplays between subject-specific hemodynamics and vascular remodeling. This aspect remains in our future directions.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"91-93"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11885045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142390829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The link between ferroptosis and autophagy in myocardial ischemia/reperfusion injury: new directions for therapy.

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-01-30 DOI: 10.1007/s12265-025-10590-6

Xiaoting Yang, Hui Wu, Di Liu, Gang Zhou, Dong Zhang, Qingzhuo Yang, Yanfang Liu, Yi Li

引用次数: 0

Mitochondrial Dysfunction in HFpEF: Potential Interventions Through Exercise. 高频心衰的线粒体功能障碍：通过运动进行潜在干预

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-01-25 DOI: 10.1007/s12265-025-10591-5

Xinxin Cui, Michail Spanos, Cuimei Zhao, Wensi Wan, Caiyue Cui, Lijun Wang, Junjie Xiao

引用次数: 0

Class III Phosphatidylinositol-3 Kinase/Vacuolar Protein Sorting 34 in Cardiovascular Health and Disease. ⅲ类磷脂酰肌醇-3激酶/液泡蛋白分选34在心血管健康和疾病中的作用。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-01-16 DOI: 10.1007/s12265-024-10581-z

Yuanjun Shen, Jason P Gleghorn

引用次数: 0

p16^INK4a Aggravated Sepsis-associated Cardiac Injury by Inhibiting the PI3K/AKT Pathway and Inducing Redox Imbalance. p16INK4a通过抑制PI3K/AKT通路和诱导氧化还原失衡加重败血症相关的心脏损伤。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-01-14 DOI: 10.1007/s12265-024-10588-6

Baihong Li, Kai Wang, Xiaoyan Wang, Zhixuan Zhang, Guangyi Huang, Yiyi Ma, Yingqiang Du, Xin Gu, Jie Hui

引用次数: 0

CRISPR-Cas9 Targeting PCSK9: A Promising Therapeutic Approach for Atherosclerosis. 靶向PCSK9的CRISPR-Cas9：一种有希望的动脉粥样硬化治疗方法

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-01-13 DOI: 10.1007/s12265-024-10587-7

Bin Gu, Min Li, Dan Li, Kaisen Huang

引用次数: 0

Development and Internal Validation of an AI-Enabled Cuff-less, Non-invasive Continuous Blood Pressure Monitor Across All Classes of Hypertension. 开发并在内部验证人工智能无袖带无创连续血压监测仪，适用于所有类型的高血压。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-01-13 DOI: 10.1007/s12265-024-10589-5

Francisco Lopez-Jimenez, Abhishek Deshmukh, John Bisognano, John Boehmer, Mouli Ramasamy, Prashanth Shyam Kumar, Suraj Kapa, Venk Varadan, Vijay Varadan, Marat Fudim

{"title":"Development and Internal Validation of an AI-Enabled Cuff-less, Non-invasive Continuous Blood Pressure Monitor Across All Classes of Hypertension.","authors":"Francisco Lopez-Jimenez, Abhishek Deshmukh, John Bisognano, John Boehmer, Mouli Ramasamy, Prashanth Shyam Kumar, Suraj Kapa, Venk Varadan, Vijay Varadan, Marat Fudim","doi":"10.1007/s12265-024-10589-5","DOIUrl":"https://doi.org/10.1007/s12265-024-10589-5","url":null,"abstract":"Background: Non-invasive, continuous blood pressure monitoring technologies require additional validation beyond standard cuff-based methods. This study evaluates a non-invasive, multiparametric wearable cuffless blood pressure (BP) diagnostic monitor across all hypertension classes with diverse subjects.Methods: A prospective, multicenter study assessed Nanowear's SimpleSense-BP performance, including induced and natural BP changes, significant BP variations (Systolic BP (SBP) ≥ ± 15 mm Hg and Diastolic BP (DBP) ≥ ± 10 mm Hg), and reference input value validity over 4 weeks.Results: 303 subjects (18-83 yrs; 50.16% Female) participated in algorithmic development and validation (Normal - 35%, Prehypertensive - 24%, Stage 1 - 24%, Stage 2 - 17%). 54 subjects were tested for induced change performance, 149 exhibited significant changes, and 91 validated reference value duration.Conclusions: The study clinically validated a continuous, AI-based BP diagnostic monitor using non-invasive wearable data. Further testing on diverse populations and external validation are recommended. The protocol was inspired by ISO 81060-2 and IEEE 1708:2019 standards.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long Non-Coding RNAs in Diabetic Cardiomyopathy: Potential Function as Biomarkers and Therapeutic Targets of Exercise Training. 长链非编码rna在糖尿病性心肌病中的潜在功能：作为生物标志物和运动训练的治疗靶点。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-01-09 DOI: 10.1007/s12265-024-10586-8

Jie Hu, Xinwen Miao, Li-Hua Yu

{"title":"Long Non-Coding RNAs in Diabetic Cardiomyopathy: Potential Function as Biomarkers and Therapeutic Targets of Exercise Training.","authors":"Jie Hu, Xinwen Miao, Li-Hua Yu","doi":"10.1007/s12265-024-10586-8","DOIUrl":"https://doi.org/10.1007/s12265-024-10586-8","url":null,"abstract":"Recent studies emphasize the beneficial effects of exercise on diabetic cardiomyopathy (DCM), adding to the growing body of evidence that underscores the role of exercise in improving health outcomes. Despite this, a notable gap persists in the number of healthcare providers who actively prescribe exercise as a therapeutic intervention for DCM management. In addition, exercise modulates the expression of lncRNAs, which play a pivotal role in DCM progression. Further investigation into this relationship may facilitate the identification of novel biomarkers and therapeutic targets for DCM. This review consolidates recent advances in identifying lncRNAs biomarkers in DCM, summarizing the current knowledge on dysregulated lncRNAs and their molecular mechanisms. Additionally, it offers new insights into the mechanistic roles of lncRNAs, highlighting their potential as biomarkers and therapeutic targets for DCM. Overall, this review aims to inform future research and reinforce the significance of addressing diabetes-related cardiovascular diseases to potentially improve clinical outcomes.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0