Journal of Cardiovascular Translational Research最新文献_第4页

IL-22 Attenuates Pressure Overload-Induced Heart Failure and Inflammation. IL-22减轻压力过载引起的心力衰竭和炎症。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-01 Epub Date: 2025-04-07 DOI: 10.1007/s12265-025-10613-2

Lanqing Xiang, Guoqing Yin, Zifan Gong, Xian Lv, Cailin Feng, Lu Liu, Fuad A Abdu, Tingting Shi, Wen Zhang, Jiasuer Alifu, Xiaojiang Xu, Yuxiang Dai, Wenliang Che, Xinyu Weng

引用次数: 0

Study of The Relationship Between Differential Small Molecule Peptides in Peripheral Blood and Arteriosclerosis in Patients with Essential Hypertension. 高血压患者外周血差异小分子肽与动脉硬化关系的研究。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-01 Epub Date: 2025-04-22 DOI: 10.1007/s12265-025-10616-z

Yunfeng Fang, Jingwen Yue, Min Zhang, Li Jiang

引用次数: 0

A Novel Angiography-Derived Computational Coronary Flow Reserve to Evaluate Non-Obstructive Coronary Artery Disease. 一种新的基于血管造影的计算冠状动脉血流储备评估非阻塞性冠状动脉疾病。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-01 Epub Date: 2025-05-19 DOI: 10.1007/s12265-025-10608-z

Jingpu Wang, Yumeng Hu, Xinyi Yang, Rende Xu, Zhangwei Chen, Zhe Wang, Leilei Ma, Feng Zhang, Xiaochang Leng, Junbo Ge, Jianping Xiang, Chenguang Li

{"title":"A Novel Angiography-Derived Computational Coronary Flow Reserve to Evaluate Non-Obstructive Coronary Artery Disease.","authors":"Jingpu Wang, Yumeng Hu, Xinyi Yang, Rende Xu, Zhangwei Chen, Zhe Wang, Leilei Ma, Feng Zhang, Xiaochang Leng, Junbo Ge, Jianping Xiang, Chenguang Li","doi":"10.1007/s12265-025-10608-z","DOIUrl":"10.1007/s12265-025-10608-z","url":null,"abstract":"Coronary flow reserve (CFR) is a key parameter for risk stratification in coronary artery disease but is limited by high cost, prolonged procedure time, and suboptimal reproducibility. We proposed a novel angiography-based method (Angio-CFR) to overcome these challenges and assessed its diagnostic performance. 107 consecutive patients underwent invasive coronary angiography with thermodilution-derived CFR (CFRthermo) were prospectively enrolled. Flow velocity at hyperemia and rest was estimated from angiographic images, and Angio-CFR was calculated as their ratio. Angio-CFR correlated well with CFRthermo (r = 0.72, p < 0.001), and showed good discrimination of CFRthermo < 2.5 (AUC = 0.879, p < 0.001) with an optimal cut-off of 2.5. The accuracy, sensitivity, and specificity of Angio-CFR were 81.71%, 83.33%, and 81.25%, respectively. Angio-CFR provides a pressure-wire-free method for coronary function assessment, demonstrating promising diagnostic accuracy and offering a more accessible approach for CFR measurement in clinical practice.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"681-688"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Dual Latex Balloon Catheter for Temporarily Closing Acute Postinfarction Ventricle Septum Defect (VSD) in a Pig Model. 一种新型双乳胶球囊导管用于暂时关闭猪急性梗死后心室间隔缺损（VSD）模型。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-01 Epub Date: 2025-03-12 DOI: 10.1007/s12265-025-10601-6

Hua-Di Qin, Yang Yang, Fei Xie, Lin Hou, Hui Gao, Jing-Wei Tang, Xiang-Sen Shao, Chun-Chang Qin

{"title":"A Novel Dual Latex Balloon Catheter for Temporarily Closing Acute Postinfarction Ventricle Septum Defect (VSD) in a Pig Model.","authors":"Hua-Di Qin, Yang Yang, Fei Xie, Lin Hou, Hui Gao, Jing-Wei Tang, Xiang-Sen Shao, Chun-Chang Qin","doi":"10.1007/s12265-025-10601-6","DOIUrl":"10.1007/s12265-025-10601-6","url":null,"abstract":"Acute postinfarction ventricular septum defect has a persistently high mortality rate due to unstable scars in the acute phase, which make surgery or occluder use unsuitable. Delayed closure increases the risk of irreversible hemodynamic deterioration. To address this, a dual latex balloon catheter was designed for temporary closure and tested in a pig model. The catheter, with a 10 French profile and 80 cm in length, includes two independent latex balloons and an anticoagulant channel to prevent thrombus formation. It was inserted via the jugular vein and guided over a 0.014-inch wire to straddle and seal the ventricular septum defect. In eight Yorkshire pigs with ventricular septum defects and acute myocardial infarction, the catheter effectively closed defects ranging from 6.1 to 10.5 mm for two weeks without complications. This innovative tool shows promise as a bridge therapy for managing acute postinfarction ventricular septum defect and warrants further evaluation.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"556-565"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12208954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143615560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Types of Post-Translational Modification of Proteins in Cardiovascular Diseases. 心血管疾病中蛋白质翻译后修饰的新类型

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-01 Epub Date: 2025-03-03 DOI: 10.1007/s12265-025-10600-7

Juntao Fang, Shaoyu Wu, Hengli Zhao, Chuanmeng Zhou, Ling Xue, Zhiyong Lei, Hui Li, Zhixin Shan

引用次数: 0

Induced Human-like Coronary Stenosis in Hypercholesterolemic PCSK9 Minipigs. 高胆固醇血症PCSK9迷你猪诱导的类人冠状动脉狭窄。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-01 Epub Date: 2025-03-25 DOI: 10.1007/s12265-025-10607-0

Jacob Nicolaisen, Christian Frøsig Bo Poulsen, Martin Mæng Bjørklund, Martin Nors Skov, Maiken Kudahl Larsen, Troels Thim, Jouke Dijkstra, Jacob Fog Bentzon, Evald Høj Christiansen, Niels Ramsing Holm

{"title":"Induced Human-like Coronary Stenosis in Hypercholesterolemic PCSK9 Minipigs.","authors":"Jacob Nicolaisen, Christian Frøsig Bo Poulsen, Martin Mæng Bjørklund, Martin Nors Skov, Maiken Kudahl Larsen, Troels Thim, Jouke Dijkstra, Jacob Fog Bentzon, Evald Høj Christiansen, Niels Ramsing Holm","doi":"10.1007/s12265-025-10607-0","DOIUrl":"10.1007/s12265-025-10607-0","url":null,"abstract":"Translational models for obstructive coronary artery disease are lacking. We aimed to develop a porcine model for obstructive coronary stenosis induced by bioresorbable stent (BRS) implantation in hypercholesterolemic proprotein convertase subtilisin/kexin-9 (PCSK9) minipigs. Fifteen hypercholesterolemic PCSK9 minipigs were randomized to percutaneous coronary intervention with Magmaris, Absorb or Desolve BRS. Optical coherence tomography (OCT) scans were performed at baseline and 6-months followed by histology. Matched OCT analysis showed minimal lumen area decreased from 7.62 ± 1.54 mm2 at baseline to 2.12 ± 0.92 mm2 at follow-up in the Magmaris group, from 6.99 ± 1.49 mm2 to 3.07 ± 1.52 mm2 in the Absorb group, and from 6.05 ± 1.11 mm2 to 2.65 ± 0.93 mm2 in the Desolve group. Histologic examination revealed advanced human-like stenosis. BRS implantation in hypercholesterolemic PCSK9 minipigs induced human-like stenoses and may serve as a feasible preclinical model for obstructive coronary artery disease.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"544-555"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanotechnology Innovations in Myocardial Infarction: Diagnosis, Treatment and the Way Forward. 纳米技术在心肌梗死中的创新：诊断、治疗和前进的道路。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-01 Epub Date: 2025-04-09 DOI: 10.1007/s12265-025-10614-1

Wenhai Wang, Dexin Xu, Jian Ding, Yinping Pan, Fang Wang, Shu Su, Xia Peng, Shitong Zhang, Wenbin Zhang

{"title":"Nanotechnology Innovations in Myocardial Infarction: Diagnosis, Treatment and the Way Forward.","authors":"Wenhai Wang, Dexin Xu, Jian Ding, Yinping Pan, Fang Wang, Shu Su, Xia Peng, Shitong Zhang, Wenbin Zhang","doi":"10.1007/s12265-025-10614-1","DOIUrl":"10.1007/s12265-025-10614-1","url":null,"abstract":"Myocardial infarction (MI) is a global health concern that necessitates continued advancements in diagnostic and therapeutic modalities. Nanotechnology facilitates prompt diagnosis and personalized treatment. This manuscript explicitly reviews the application of innovative methodologies for identifying cardiac biomarkers to facilitate the early diagnosis of MI and its clinical management. Nanoscale agents such as nanoparticles and nanosensors have been employed for this purpose. Technological advancements in medical imaging are revolutionizing therapeutic approaches while reducing morbidity and mortality typically associated with cardiac tissue injury. Besides all, applications of nanotechnology in therapeutics have proven extremely effective. The development of nanoparticle-based customized drug delivery systems will contribute to more effective treatments, fewer side effects, and improved therapeutic outcomes. Biomaterials and nanoscale surgical technologies may benefit patients with MI by promoting tissue regeneration and repair. This manuscript also investigates the ethical and legal limitations that could prevent seamless incorporation of nanotechnology into clinical practice.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"484-497"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Apelin13 Loaded Nano-Niosomes Confer Cardioprotection in a Rat Model of Myocardial Ischemia Reperfusion by Targeting the Nrf2/HO-1 Pathway. Apelin13负载纳米粒体通过靶向Nrf2/HO-1通路在大鼠心肌缺血再灌注模型中赋予心脏保护作用

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-01 Epub Date: 2025-02-19 DOI: 10.1007/s12265-025-10597-z

Neda Tekiyeh Maroof, Saeed Mehrzadi, Maryam Naseroleslami, Nahid Aboutaleb

{"title":"Apelin13 Loaded Nano-Niosomes Confer Cardioprotection in a Rat Model of Myocardial Ischemia Reperfusion by Targeting the Nrf2/HO-1 Pathway.","authors":"Neda Tekiyeh Maroof, Saeed Mehrzadi, Maryam Naseroleslami, Nahid Aboutaleb","doi":"10.1007/s12265-025-10597-z","DOIUrl":"10.1007/s12265-025-10597-z","url":null,"abstract":"Although apelin-13 has cardioprotective impact, its short half-life in the bloodstream has challenged its clinical application. Using nanocarriers can increase the bioavailability, functionality, and stability of drugs. Current investigation aims to find whether apelin13-loaded nano-niosomes confer cardioprotection in an animal model of myocardial ischemia/reperfusion injury (MI/R) via suppressing ferroptosis, targeting Nrf2 pathway, and AMPK/GSK-3β axis. Ligation of the left anterior coronary artery descending was done to establish the MI/R model and 15 μg/kg of apelin13-loaded nano-niosomes were intramyocardially administrated. Echocardiography, RT-PCR, immunohistochemistry, western blot, ELISA kits, and H&E staining were applied to measure the related indicators. Treatment with both apelin13 and apelin13 loaded nano-niosomes could improve cardiac function and attenuate oxidative stress, myocardial inflammatory factors, and hence ferroptosis by activating the Nrf2 and its downstream proteins HO1, NQO1, AMPK/GSK-3β signaling pathway. In conclusion, apelin13-loaded nano-niosomes are effective MI therapeutic agents against MI/R-induced ferroptosis by activation of Nrf2 via AMPK/GSK-3β axis.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"529-543"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibition of Egr2 Protects against TAC-induced Heart Failure in Mice by Suppressing Inflammation and Apoptosis Via Targeting Acot1 in Cardiomyocytes. 抑制Egr2通过靶向心肌细胞Acot1抑制炎症和凋亡来保护tac诱导的小鼠心力衰竭

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-01 Epub Date: 2025-03-17 DOI: 10.1007/s12265-025-10602-5

Xiaolu Hou, Guoling Hu, Heling Wang, Ying Yang, Qi Sun, Xiuping Bai

{"title":"Inhibition of Egr2 Protects against TAC-induced Heart Failure in Mice by Suppressing Inflammation and Apoptosis Via Targeting Acot1 in Cardiomyocytes.","authors":"Xiaolu Hou, Guoling Hu, Heling Wang, Ying Yang, Qi Sun, Xiuping Bai","doi":"10.1007/s12265-025-10602-5","DOIUrl":"10.1007/s12265-025-10602-5","url":null,"abstract":"Heart failure (HF) is a clinical syndrome caused by structural or functional abnormalities in heart. Egr2 has been reported to be protective for multiple diseases, but its effect on HF remains unknown. The present study intended to investigate the potential role of Egr2 in HF and its possible downstream effectors. High Egr2 expression in heart was observed in HF mice. Egr2 knockdown alleviated cardiac damage and function in HF mice. Egr2 knockdown inhibited myocardial inflammation and apoptosis both in vivo and in vitro. Egr2 inhibited Acot1 transcription expression via directly binding to its promoter. Acot1 overexpression reduced Lipopolysaccharide (LPS)-induced cardiomyocyte inflammation and apoptosis. Functional rescue experiments revealed that Acot1 reversed the effects of Egr2 on LPS-induced cell apoptosis and inflammation. Overall, Egr2 knockdown might ameliorate HF by inhibiting inflammation and apoptosis in cardiomyocytes by targeting Acot1. This study might provide evidence to better understand the molecular mechanisms of HF pathogenesis.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"574-585"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LACC1 Enhances Polyamine Immunometabolism in Inflammatory Macrophages to Inhibit Atherosclerosis Progression. LACC1增强炎性巨噬细胞多胺免疫代谢抑制动脉粥样硬化进展

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-06-01 Epub Date: 2025-04-28 DOI: 10.1007/s12265-024-10585-9

Jingyong Zhang, Yuan Xu, Zonglin Han, Bingqi Liu, Maohua Wang, Lili Bao, Yuxiang He

{"title":"LACC1 Enhances Polyamine Immunometabolism in Inflammatory Macrophages to Inhibit Atherosclerosis Progression.","authors":"Jingyong Zhang, Yuan Xu, Zonglin Han, Bingqi Liu, Maohua Wang, Lili Bao, Yuxiang He","doi":"10.1007/s12265-024-10585-9","DOIUrl":"10.1007/s12265-024-10585-9","url":null,"abstract":"To explore the function and potential mechanism of laccase domain-containing 1 (LACC1) on atherosclerosis (AS). ApoE-/- mice feed with high-fat diet (HFD) were injected with adenovirus shLACC1 (Ad-shLACC1) or Ad-shNC via tail vein. LACC1 was highly expressed in macrophages of atherosclerotic plaque in ApoE-/- mice and ox-LDL-treated Raw264.7 macrophages. LACC1 silencing enhanced AS development and facilitated inflammation in mice. Then, we found that LACC1 silencing facilitated inflammation but repressed polyamine immunometabolism in ox-LDL-treated Raw264.7 macrophages. Through rescue experiments using ornithine or ODC1 inhibitor (DFMO), we further confirmed that LACC1 promoted polyamine immunometabolism to inhibit inflammation in ox-LDL-treated Raw264.7 macrophages. In addition, the observed LACC1 function was dependent on NOS2. In conclusion, we proved that the downregulation of LACC1 promoted AS progression via inhibiting polyamine immunometabolism in inflammatory macrophages, suggesting LACC1 may be a potential therapeutic target for AS.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"459-470"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0