Study of The Relationship Between Differential Small Molecule Peptides in Peripheral Blood and Arteriosclerosis in Patients with Essential Hypertension.
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引用次数: 0
Abstract
This study investigated the association between serum small peptides and arteriosclerosis (AS) in hypertensive patients. Sixty hypertensive patients (with and without AS) and 30 healthy individuals were enrolled. Untargeted metabolomics identified 120 peptides in AS patients, 136 in hypertensive patients, and 59 shared peptides. LASSO regression identified key peptides differentiating hypertensive patients with AS from those without. Peptides like Thr-Ile, Phe-Asp-Lys, and Lys-Ile-Val-Lys were upregulated in AS, while others like Gln-Glu and Lys-Lys were higher in non-AS patients. The diagnostic model showed AUCs of 0.896 for AS and 0.909 for non-AS. Elevated levels of Lys-Ile-Val-Lys and Phe-Asp-Lys were linked to increased carotid intima-media thickness, indicating higher AS risk.
本研究探讨高血压患者血清小肽与动脉硬化（AS）的关系。60例高血压患者（伴有和不伴有AS）和30名健康个体被纳入研究。非靶向代谢组学鉴定出AS患者中有120个多肽，高血压患者中有136个多肽，59个共有多肽。LASSO回归确定了区分高血压AS患者与非高血压AS患者的关键肽。如Thr-Ile、Phe-Asp-Lys和Lys-Ile-Val-Lys等肽在AS患者中表达上调，而其他肽如Gln-Glu和Lys-Lys在非AS患者中表达较高。诊断模型显示，AS的auc为0.896，非AS的auc为0.909。lys - ile - valley - lys和Phe-Asp-Lys水平升高与颈动脉内膜-中膜厚度增加有关，表明AS风险增加。
期刊介绍：
Journal of Cardiovascular Translational Research (JCTR) is a premier journal in cardiovascular translational research.
JCTR is the journal of choice for authors seeking the broadest audience for emerging technologies, therapies and diagnostics, pre-clinical research, and first-in-man clinical trials.
JCTR''s intent is to provide a forum for critical evaluation of the novel cardiovascular science, to showcase important and clinically relevant aspects of the new research, as well as to discuss the impediments that may need to be overcome during the translation to patient care.
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