Induced Human-like Coronary Stenosis in Hypercholesterolemic PCSK9 Minipigs.

IF 2.4 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiovascular Translational Research Pub Date : 2025-03-25 DOI:10.1007/s12265-025-10607-0

Jacob Nicolaisen, Christian Frøsig Bo Poulsen, Martin Mæng Bjørklund, Martin Nors Skov, Maiken Kudahl Larsen, Troels Thim, Jouke Dijkstra, Jacob Fog Bentzon, Evald Høj Christiansen, Niels Ramsing Holm

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Abstract

Translational models for obstructive coronary artery disease are lacking. We aimed to develop a porcine model for obstructive coronary stenosis induced by bioresorbable stent (BRS) implantation in hypercholesterolemic proprotein convertase subtilisin/kexin-9 (PCSK9) minipigs. Fifteen hypercholesterolemic PCSK9 minipigs were randomized to percutaneous coronary intervention with Magmaris, Absorb or Desolve BRS. Optical coherence tomography (OCT) scans were performed at baseline and 6-months followed by histology. Matched OCT analysis showed minimal lumen area decreased from 7.62 ± 1.54 mm² at baseline to 2.12 ± 0.92 mm² at follow-up in the Magmaris group, from 6.99 ± 1.49 mm² to 3.07 ± 1.52 mm² in the Absorb group, and from 6.05 ± 1.11 mm² to 2.65 ± 0.93 mm² in the Desolve group. Histologic examination revealed advanced human-like stenosis. BRS implantation in hypercholesterolemic PCSK9 minipigs induced human-like stenoses and may serve as a feasible preclinical model for obstructive coronary artery disease.

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高胆固醇血症PCSK9迷你猪诱导的类人冠状动脉狭窄。

阻塞性冠状动脉疾病的翻译模型缺乏。我们的目的是建立一个生物可吸收支架（BRS）植入术在高胆固醇蛋白转化酶枯草素/酶切蛋白-9 （PCSK9）迷你猪中引起的阻塞性冠状动脉狭窄的猪模型。15头高胆固醇血症的PCSK9型小型猪随机接受Magmaris、absordve或solve BRS的经皮冠状动脉介入治疗。光学相干断层扫描（OCT）在基线和6个月后进行组织学检查。匹配OCT分析显示，Magmaris组最小管腔面积从基线时的7.62±1.54 mm2降至随访时的2.12±0.92 mm2， absordate组从6.99±1.49 mm2降至3.07±1.52 mm2， soluve组从6.05±1.11 mm2降至2.65±0.93 mm2。组织学检查显示晚期人样狭窄。BRS植入高胆固醇血症的PCSK9小型猪诱导类似人的狭窄，可能作为阻塞性冠状动脉疾病的可行临床前模型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cardiovascular Translational Research CARDIAC & CARDIOVASCULAR SYSTEMS-MEDICINE, RESEARCH & EXPERIMENTAL

CiteScore

6.10

自引率

2.90%

发文量

148

审稿时长

6-12 weeks

期刊介绍： Journal of Cardiovascular Translational Research (JCTR) is a premier journal in cardiovascular translational research. JCTR is the journal of choice for authors seeking the broadest audience for emerging technologies, therapies and diagnostics, pre-clinical research, and first-in-man clinical trials. JCTR''s intent is to provide a forum for critical evaluation of the novel cardiovascular science, to showcase important and clinically relevant aspects of the new research, as well as to discuss the impediments that may need to be overcome during the translation to patient care.