收缩压变异性和动脉僵硬度与心血管疾病的个体和联合关联：一项前瞻性队列研究

IF 2.4 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiovascular Translational Research Pub Date : 2025-06-20 DOI:10.1007/s12265-025-10644-9

Ming Gao, Wei Pan, Tianqi Ma, Qunyong Pen, Rong Cao, Chenxuan Zhao, Jun Yi

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引用次数: 0

摘要

收缩压变异性（SBPV）和动脉僵硬指数（ASI）是心血管疾病（CVD）的危险因素，但它们的独立和联合作用尚不清楚。本研究使用来自28,792名英国生物银行参与者的数据调查了它们之间的关联，这些参与者在基线时没有心血管疾病。将SBPV和ASI分为四分位数，并使用Cox回归评估其对CVD风险的影响。在平均12.29年的随访中，发生了3,967例心血管疾病事件。较高的SBPV和ASI与CVD风险增加独立相关(SBPV Q4: HR 1.25 [1.14-1.38]；Asi q4: hr 1.24[1.12-1.36])。观察到乘法相互作用（p = 0.019），它们的联合作用进一步增加了风险（SBPV Q4 + ASI Q4: HR 1.63[1.32-2.02]）。这些发现表明SBPV和ASI单独或共同导致CVD风险，强调需要有针对性的干预措施。

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The Individual and Joint Associations of Systolic Blood Pressure Variability and Arterial Stiffness with Cardiovascular Disease: A Prospective Cohort Study.

Systolic blood pressure variability (SBPV) and arterial stiffness index (ASI) are risk factors for cardiovascular diseases (CVD), but their independent and combined effects remain unclear. This study investigated their associations using data from 28,792 UK Biobank participants without CVD at baseline. SBPV and ASI were categorized into quartiles, and Cox regression was used to assess their effects on CVD risk. Over an average follow-up of 12.29 years, 3,967 CVD events occurred. Higher SBPV and ASI were independently associated with increased CVD risk (SBPV Q4: HR 1.25 [1.14-1.38]; ASI Q4: HR 1.24 [1.12-1.36]). A multiplicative interaction was observed (p = 0.019), and their combined effect further elevated risk (SBPV Q4 + ASI Q4: HR 1.63 [1.32-2.02]). These findings suggest SBPV and ASI independently and jointly contribute to CVD risk, highlighting the need for targeted interventions.

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来源期刊

Journal of Cardiovascular Translational Research CARDIAC & CARDIOVASCULAR SYSTEMS-MEDICINE, RESEARCH & EXPERIMENTAL

CiteScore

6.10

自引率

2.90%

发文量

148

审稿时长

6-12 weeks

期刊介绍： Journal of Cardiovascular Translational Research (JCTR) is a premier journal in cardiovascular translational research. JCTR is the journal of choice for authors seeking the broadest audience for emerging technologies, therapies and diagnostics, pre-clinical research, and first-in-man clinical trials. JCTR''s intent is to provide a forum for critical evaluation of the novel cardiovascular science, to showcase important and clinically relevant aspects of the new research, as well as to discuss the impediments that may need to be overcome during the translation to patient care.