Exosomal miRNAs: A New Frontier in Cardiovascular Disease Diagnosis and Treatment.

IF 2.4 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiovascular Translational Research Pub Date : 2025-06-19 DOI:10.1007/s12265-025-10617-y

Sun Qingpiao, Zhang Yi

引用次数: 0

Abstract

Exosomes are small vesicles secreted by a variety of cells surrounded by a lipid bilayer membrane and containing a variety of biomolecules, of which microRNAs (miRNAs) are the most abundant. Exosomal miRNAs are involved in the development of cardiovascular diseases(CVD), and their unique biological properties make them expected to be effective targets for the treatment of CVD. This article reviews the biological characteristics, expression, and mechanism of action of exosomes and exosomal miRNAs in CVD, as well as their potential as biomarkers in the diagnosis, treatment, and prognostic assessment of CVD, to provide new ideas in the field of CVD medicine.

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外泌体mirna：心血管疾病诊断和治疗的新前沿。

外泌体是由脂质双层膜包围的多种细胞分泌的小囊泡，含有多种生物分子，其中以microrna （mirna）最为丰富。外泌体mirna参与心血管疾病（CVD）的发展，其独特的生物学特性使其有望成为治疗CVD的有效靶点。本文综述了外泌体和外泌体mirna在CVD中的生物学特性、表达、作用机制，以及它们作为CVD诊断、治疗和预后评估生物标志物的潜力，以期为CVD医学领域提供新的思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cardiovascular Translational Research CARDIAC & CARDIOVASCULAR SYSTEMS-MEDICINE, RESEARCH & EXPERIMENTAL

CiteScore

6.10

自引率

2.90%

发文量

148

审稿时长

6-12 weeks

期刊介绍： Journal of Cardiovascular Translational Research (JCTR) is a premier journal in cardiovascular translational research. JCTR is the journal of choice for authors seeking the broadest audience for emerging technologies, therapies and diagnostics, pre-clinical research, and first-in-man clinical trials. JCTR''s intent is to provide a forum for critical evaluation of the novel cardiovascular science, to showcase important and clinically relevant aspects of the new research, as well as to discuss the impediments that may need to be overcome during the translation to patient care.