Journal of Cardiovascular Translational Research最新文献_第9页

Increased Expression of Inactive Rhomboid Protein 2 in Circulating Monocytes after Acute Myocardial Infarction. 急性心肌梗死后循环单核细胞中的非活性Rhomboid蛋白2表达增加

IF 4.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-10-01 Epub Date: 2024-05-14 DOI: 10.1007/s12265-024-10519-5

Phillip van Dijck, Carmen Hannemann, Henryk Dreger, Verena Stangl, Karl Stangl, Antje Ludwig, Bernd Hewing

{"title":"Increased Expression of Inactive Rhomboid Protein 2 in Circulating Monocytes after Acute Myocardial Infarction.","authors":"Phillip van Dijck, Carmen Hannemann, Henryk Dreger, Verena Stangl, Karl Stangl, Antje Ludwig, Bernd Hewing","doi":"10.1007/s12265-024-10519-5","DOIUrl":"10.1007/s12265-024-10519-5","url":null,"abstract":"Increased TNF-α levels following acute myocardial infarction (AMI) contribute to impaired recovery of myocardial function. Interaction of inactive rhomboid protein 2 (iRhom2) with TNF-α converting enzyme (TACE) is required for TNF-α shedding from immune cells. We hypothesized that iRhom2 expression increases in circulating monocytes following AMI. Transcript levels of iRhom2, TACE and TNF-α were evaluated by quantitative real-time PCR in isolated monocytes of 50 AMI patients at admission (d1) and 3 days (d3) after. We observed a significant increase in levels of iRhom2 mRNA expression in monocytes between d1-3, while TNF-α and TACE mRNA expression remained unchanged. At d3, iRhom2 mRNA expression positively correlated with levels of intermediate monocytes or serum TNF-α, and negatively with LV systolic function. iRhom2 may contribute to regulation of post-infarction inflammation and is associated with LV dysfunction following AMI. iRhom2 modulation should be evaluated as a potential therapeutic strategy to attenuate cardiac remodeling following AMI.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"1059-1066"},"PeriodicalIF":4.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11519168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140922360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vaccarin Ameliorates Doxorubicin-Induced Cardiotoxicity via Inhibition of p38 MAPK Mediated Mitochondrial Dysfunction. Vaccarin 通过抑制 p38 MAPK 介导的线粒体功能障碍改善多柔比星诱发的心脏毒性

IF 4.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-10-01 Epub Date: 2024-06-17 DOI: 10.1007/s12265-024-10525-7

Xin Shi, Yang Cao, Hongyu Wang, Qi Zhao, Cong Yan, Shengzhu Li, Ling Jing

{"title":"Vaccarin Ameliorates Doxorubicin-Induced Cardiotoxicity via Inhibition of p38 MAPK Mediated Mitochondrial Dysfunction.","authors":"Xin Shi, Yang Cao, Hongyu Wang, Qi Zhao, Cong Yan, Shengzhu Li, Ling Jing","doi":"10.1007/s12265-024-10525-7","DOIUrl":"10.1007/s12265-024-10525-7","url":null,"abstract":"Doxorubicin is a frequently used chemotherapeutic agent for treating various malignancies. However, it leads to severe cardiotoxic side effects, such as heart failure, and elevates the risk of sudden cardiac death among cancer patients. While oxidative stress has been identified as the primary cause of doxorubicin-induced cardiotoxicity, therapeutic antioxidant approaches have yielded unsatisfactory outcomes. The aim of this study is to explore the therapeutic potential of vaccarin, an active flavonoid glycoside extracted from traditional Chinese herbal agent Semen Vaccariae, in doxorubicin-induced cardiotoxicity. We observed that vaccarin significantly ameliorates doxorubicin-induced heart dysfunction in mouse model and suppresses oxidative stress mediated cell apoptosis via specifically inhibiting the activation of p38 MAPK pathway. In vitro, we observed that vaccarin alleviates doxorubicin-induced mitochondrial membrane depolarization and ROS generation in H9c2 cell, but the p38 MAPK agonist anisomycin reverses these effects. Our findings provide a promising natural antioxidant to protect against DOX-induced cardiotoxicity.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"1155-1171"},"PeriodicalIF":4.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11519163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141419254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathogenic Autoimmunity in Atherosclerosis Evolves from HSP60-Reactive CD4 + T Cells. 动脉粥样硬化中的致病性自身免疫由 HSP60 反应性 CD4 + T 细胞演变而来

IF 4.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-10-01 Epub Date: 2024-05-20 DOI: 10.1007/s12265-024-10516-8

Shixiang Wang, Yongquan Chen, Danyan Zhou, Jiawei Zhang, Guofeng Guo, Youquan Chen

{"title":"Pathogenic Autoimmunity in Atherosclerosis Evolves from HSP60-Reactive CD4 + T Cells.","authors":"Shixiang Wang, Yongquan Chen, Danyan Zhou, Jiawei Zhang, Guofeng Guo, Youquan Chen","doi":"10.1007/s12265-024-10516-8","DOIUrl":"10.1007/s12265-024-10516-8","url":null,"abstract":"Clinical evidence suggests anti-Hsp60 antibodies could contribute to atherosclerosis (AS) development, with unclear mechanisms. This study aims to explore the role of anti-HSP60-mediated autoimmunity in AS progression. HSP60-MHC tetramers were used to characterize HSP60-specific CD4 + T cells and assess TCR responses in mice. These cells were transplanted into AS mice to examine immune cell differentiation and infiltration in plaques and blood. Mice were injected with recombinant HSP60 or anti-HSP60 sera to evaluate effects on plaque progression and macrophage activity. Experiments with muMT-/-Apoe-/- mice examined humoral immunity's role in this autoimmunity. HSP60-reactive CD4 + T cells in AS mice differentiated into follicular helper cells, not Th1/Th17. Anti-HSP60 treatments increased macrophage infiltration and M1 polarization, indicating an anti-HSP60-driven inflammatory progression, dependent on humoral immunity. Anti-HSP60 influences macrophage infiltration, polarization, and plaque formation via humoral immunity, shedding light on its potential role in AS progression.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"1172-1180"},"PeriodicalIF":4.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibition of METTL4: Targeting a Methyltransferase that Alleviates Heart Failure by Modulating Excess N6-Methyladenine in Mitochondrial DNA. 抑制 METTL4：靶向甲基转移酶，通过调节线粒体 DNA 中过量的 N6-甲基腺嘌呤缓解心力衰竭。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-10-01 Epub Date: 2024-07-11 DOI: 10.1007/s12265-024-10535-5

Jiaqi Wang, Michail Spanos, Yihua Bei

引用次数: 0

A Novel Swine Model for Inducing Functional Tricuspid Valve Regurgitation. 诱导功能性三尖瓣反流的新型猪模型

IF 4.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-10-01 Epub Date: 2024-05-16 DOI: 10.1007/s12265-024-10510-0

Dawei Lin, Peng Zhang, Yongchao Zhao, Wanjiao Chen, Dandan Chen, Xiaochun Zhang, Daxin Zhou, Junbo Ge

{"title":"A Novel Swine Model for Inducing Functional Tricuspid Valve Regurgitation.","authors":"Dawei Lin, Peng Zhang, Yongchao Zhao, Wanjiao Chen, Dandan Chen, Xiaochun Zhang, Daxin Zhou, Junbo Ge","doi":"10.1007/s12265-024-10510-0","DOIUrl":"10.1007/s12265-024-10510-0","url":null,"abstract":"Functional tricuspid regurgitation (FTR) is the most common TR, although experimental models to effectively study it are scarce; therefore, this study aimed to establish a robust experimental swine model. A swine FTR model was developed using radiofrequency ablation, atrial septostomy, and right atrial volume overload. The baseline and follow-up echocardiography was performed to evaluate the progression FTR and changes in the heart. Autopsy was employed to verify the anatomy of tricuspid valve. One-month post intervention, among the subjects, one (8.3%) exhibited severe FTR, eight (66.7%) exhibited moderate TR, and three (25%) exhibited mild FTR. Each pig developed an atrial septal defect (diameter, 1.5 ± 0.5 cm). The tricuspid annular diameter significantly increased with enlargement of right heart (P < 0.05). No significant difference was found on left heart size and mitral regurgitation. We successfully developed a novel swine FTR model, providing a reliable and effective platform for further research on FTR.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"1004-1010"},"PeriodicalIF":4.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11519177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular Vesicles to Predict Outcomes After Transcatheter Aortic Valve Implantation - a Prospective, Multicenter Cohort Study. 预测经导管主动脉瓣植入术后预后的细胞外小泡--一项前瞻性多中心队列研究。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-10-01 Epub Date: 2024-05-28 DOI: 10.1007/s12265-024-10521-x

Radosław Wilimski, Jan Budzianowski, Michał Łomiak, Anna Olasińska-Wiśniewska, Katarzyna Pieniak, Szymon Jędrzejczyk, Olaf Domaszk, Magdalena Chudzik, Krzysztof J Filipiak, Jarosław Hiczkiewicz, Wojciech Faron, Tomasz Urbanowicz, Marek Jemielity, Marek Grygier, Marcin Grabowski, Mariusz Kuśmierczyk, Bartosz Rymuza, Zenon Huczek, Janusz Kochman, Edwin van der Pol, Rienk Nieuwland, Aleksandra Gąsecka

{"title":"Extracellular Vesicles to Predict Outcomes After Transcatheter Aortic Valve Implantation - a Prospective, Multicenter Cohort Study.","authors":"Radosław Wilimski, Jan Budzianowski, Michał Łomiak, Anna Olasińska-Wiśniewska, Katarzyna Pieniak, Szymon Jędrzejczyk, Olaf Domaszk, Magdalena Chudzik, Krzysztof J Filipiak, Jarosław Hiczkiewicz, Wojciech Faron, Tomasz Urbanowicz, Marek Jemielity, Marek Grygier, Marcin Grabowski, Mariusz Kuśmierczyk, Bartosz Rymuza, Zenon Huczek, Janusz Kochman, Edwin van der Pol, Rienk Nieuwland, Aleksandra Gąsecka","doi":"10.1007/s12265-024-10521-x","DOIUrl":"10.1007/s12265-024-10521-x","url":null,"abstract":"Introduction: Transcatheter aortic valve implantation (TAVI) is an established treatment for aortic stenosis (AS) in patients at intermediate and high surgical risk. Circulating extracellular vesicles (EVs) are nanoparticles involved in cardiovascular diseases. We aimed to (i) determine the effect of TAVI on plasma concentrations of five EV subtypes and (ii) evaluate the predictive value of EVs for post-TAVI outcomes.Methods: Blood samples were collected 1 day before TAVI and at hospital discharge. Concentrations of EVs were evaluated using flow cytometry.Results: Concentration of leukocytes EVs decreased after TAVI, compared to the measurement before (p = 0.008). Among 123 patients discharged from the hospital, 19.5% experienced MACCE during the median of 10.3 months. Increased pre-TAVI concentration of phosphatidylserine-exposing EVs was an independent predictor of MACCE in multivariable analysis (OR 5.313, 95% CI 1.164-24.258, p = 0.031).Conclusions: Patients with increased pre-TAVI concentration of procoagulant, PS-exposing EVs have over fivefold higher odds of adverse outcomes.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"992-1003"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11519094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141160041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Updated Comprehensive Review of Existing Transcatheter Aortic Valve Replacement Access. 对现有经导管主动脉瓣置换术通路的最新全面回顾。

IF 4.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-10-01 Epub Date: 2024-08-26 DOI: 10.1007/s12265-024-10484-z

Wenjing Sheng, Hanyi Dai, Rongrong Zheng, Ailifeire Aihemaiti, Xianbao Liu

引用次数: 0

The activation of P38MAPK Signaling Pathway Impedes the Delivery of the Cx43 to the Intercalated Discs During Cardiac Ischemia-Reperfusion Injury. 在心脏缺血再灌注损伤过程中，P38MAPK 信号通路的激活阻碍了 Cx43 向椎间盘的输送。

IF 4.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-10-01 Epub Date: 2024-05-02 DOI: 10.1007/s12265-024-10515-9

Xiang Huang, Xue Bai, Jing Yi, Tingju Hu, Li An, Hong Gao

{"title":"The activation of P38MAPK Signaling Pathway Impedes the Delivery of the Cx43 to the Intercalated Discs During Cardiac Ischemia-Reperfusion Injury.","authors":"Xiang Huang, Xue Bai, Jing Yi, Tingju Hu, Li An, Hong Gao","doi":"10.1007/s12265-024-10515-9","DOIUrl":"10.1007/s12265-024-10515-9","url":null,"abstract":"Ischemic heart disease is caused by coronary artery occlusion. Despite the increasing number and success of interventions for restoring coronary artery perfusion, myocardial ischemia-reperfusion (I/R) injury remains a significant cause of morbidity and mortality worldwide. Inspired by the impact of I/R on the Cx43 trafficking to the intercalated discs (ICDs), we aim to explore the potential mechanisms underlying the downregulation of Cx43 in ICDs after myocardial I/R. Gene set enrichment analysis (GSEA), Western blotting, and immunofluorescence experiments showed that Myocardial I/R activated the P38MAPK signaling pathway and promoted microtubule depolymerization. Inhibition of P38MAPK signaling pathway activation attenuated I/R-induced microtubule depolymerization. The ability of SB203580 to recover the distribution of Cx43 and electrophysiological parameters in I/R myocardium depended on microtubule stability. Our study suggests that microtubule depolymerization caused by the activation of the P38MAPK signaling pathway is an important mechanism underlying the downregulation of Cx43 in ICDs after myocardial I/R.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"1140-1154"},"PeriodicalIF":4.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140855101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Genetic Factors Influencing Cardiomyopathies and Heart Failure across the Allele Frequency Spectrum. 影响心肌病和心力衰竭的各种等位基因频率的遗传因素。

IF 4.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-10-01 Epub Date: 2024-05-21 DOI: 10.1007/s12265-024-10520-y

Srinjay Mukhopadhyay, Prithvi Dixit, Najiyah Khanom, Gianluca Sanghera, Kathryn A McGurk

引用次数: 0

Exosome is a Fancy Mobile Sower of Ferroptosis. 外泌体是铁突变的花式移动播种机。

IF 4.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-10-01 Epub Date: 2024-05-22 DOI: 10.1007/s12265-024-10508-8

Qin Hou, Siyu Ouyang, Zhongcheng Xie, Yinling He, Yunong Deng, Jiamin Guo, Panpan Yu, Xiaoqian Tan, Wentao Ma, Pin Li, Jiang Yu, Qinger Mo, Zhixia Zhang, Dandan Chen, Xiaoyan Lin, Zhiyang Liu, Xi Chen, Tianhong Peng, Liang Li, Wei Xie

{"title":"Exosome is a Fancy Mobile Sower of Ferroptosis.","authors":"Qin Hou, Siyu Ouyang, Zhongcheng Xie, Yinling He, Yunong Deng, Jiamin Guo, Panpan Yu, Xiaoqian Tan, Wentao Ma, Pin Li, Jiang Yu, Qinger Mo, Zhixia Zhang, Dandan Chen, Xiaoyan Lin, Zhiyang Liu, Xi Chen, Tianhong Peng, Liang Li, Wei Xie","doi":"10.1007/s12265-024-10508-8","DOIUrl":"10.1007/s12265-024-10508-8","url":null,"abstract":"Exosomes, nano-sized small extracellular vesicles, have been shown to serve as mediators between intercellular communications by transferring bioactive molecules, such as non-coding RNA, proteins, and lipids from secretory to recipient cells, modulating a variety of physiological and pathophysiological processes. Recent studies have gradually demonstrated that altered exosome charges may represent a key mechanism driving the pathological process of ferroptosis. This review summarizes the potential mechanisms and signal pathways relevant to ferroptosis and then discusses the roles of exosome in ferroptosis. As well as transporting iron, exosomes may also indirectly convey factors related to ferroptosis. Furthermore, ferroptosis may be transmitted to adjacent cells through exosomes, resulting in cascading effects. It is expected that further research on exosomes will be conducted to explore their potential in ferroptosis and will lead to the creation of new therapeutic avenues for clinical diseases.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"1067-1082"},"PeriodicalIF":4.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141076036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0