Journal of Cardiovascular Translational Research最新文献_第8页

Plasma Biomarker Screening Based on Proteomic Signature of Patients with Resistant Hypertension. 基于难治性高血压患者蛋白质组特征的血浆生物标志物筛查

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-12-01 Epub Date: 2024-07-06 DOI: 10.1007/s12265-024-10541-7

Jianmin Du, Xiaoqian Yu, Wenyu Zhang, Xinghai Zhang, Hengli Zhao, Rui Xu, Qing Wen

引用次数: 0

Adult Cardiomyocyte-Derived Extracellular Vesicles: a Promising Therapy for Cardiac Fibrosis. 成人心肌细胞衍生的细胞外囊泡：一种治疗心脏纤维化的有效疗法

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-12-01 Epub Date: 2024-08-26 DOI: 10.1007/s12265-024-10554-2

Hongyun Wang, Xinpeng Li, Qianwen Wu, Wei Chen, Yihua Bei

引用次数: 0

Hyperspectral Imaging for Microcirculatory Assessment of Patients undergoing Transcatheter and Surgical Aortic Valve Replacement-a Prospective Observational Pilot Study. 用于经导管主动脉瓣置换术和外科主动脉瓣置换术患者微循环评估的高光谱成像--一项前瞻性观察试点研究。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-11-08 DOI: 10.1007/s12265-024-10573-z

Maximilian Dietrich, Aycan Tayan, Tobias Hölle, Christian Nusshag, Anne-Christine Kapp, Christina Mertens, Alexander Studier-Fischer, Felix Nickel, Florian Leuschner, Markus Alexander Weigand, Matthias Karck, Christoph Lichtenstern, Rawa Arif, Dania Fischer

{"title":"Hyperspectral Imaging for Microcirculatory Assessment of Patients undergoing Transcatheter and Surgical Aortic Valve Replacement-a Prospective Observational Pilot Study.","authors":"Maximilian Dietrich, Aycan Tayan, Tobias Hölle, Christian Nusshag, Anne-Christine Kapp, Christina Mertens, Alexander Studier-Fischer, Felix Nickel, Florian Leuschner, Markus Alexander Weigand, Matthias Karck, Christoph Lichtenstern, Rawa Arif, Dania Fischer","doi":"10.1007/s12265-024-10573-z","DOIUrl":"https://doi.org/10.1007/s12265-024-10573-z","url":null,"abstract":"This prospective, observational study evaluated Hyperspectral Imaging (HSI) to assess the effects of cardiac surgery and cardiopulmonary bypass (CPB) on microcirculation. 40 Patients with severe aortic stenosis were enrolled. 20 patients underwent transapical/transaxillary/transaortic aortic valve replacement (TAVR), 20 underwent an open surgical approach with CPB (SAVR). HSI was used to determine tissue oxygenation (StO2 and NIR), hemoglobin (THI) and water content (TWI) at the palm before/after surgery (T1/T2), and on the third postoperative day (T3). TAVR patients showed no significant changes of microcirculatory parameters during surgery. TWI significantly increased until T3. SAVR patients showed an increase of TWI and a decrease of THI, while StO2 and NIR remained unchanged at T2. In SAVR patients, StO2 and NIR correlated negatively with the duration of CPB and StO2 correlated with intraoperative urine output at T2. HSI was able to detect microcirculatory changes during cardiac surgery. CPB duration seemed to affect tissue oxygenation. Clinical trial registration: (German Clinical Trial Register): DRKS00024765.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical and Geometric Characterization of a Novel 2-Ply Vacuum-Pressed Biological Scaffold Patch Design for Posterior Mitral Valve Reconstruction. 用于二尖瓣后瓣重建的新型双层真空压制生物支架补片设计的机械和几何特性。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-10-28 DOI: 10.1007/s12265-024-10572-0

Johannes H Jedrzejczyk, Frederik T Andersen, Jacob Petersen, Alexander Emil Kaspersen, Urjosee Sahana, Søren N Skov, Jens T Væsel, J Michael Hasenkam, Marcell J Tjørnild

{"title":"Mechanical and Geometric Characterization of a Novel 2-Ply Vacuum-Pressed Biological Scaffold Patch Design for Posterior Mitral Valve Reconstruction.","authors":"Johannes H Jedrzejczyk, Frederik T Andersen, Jacob Petersen, Alexander Emil Kaspersen, Urjosee Sahana, Søren N Skov, Jens T Væsel, J Michael Hasenkam, Marcell J Tjørnild","doi":"10.1007/s12265-024-10572-0","DOIUrl":"https://doi.org/10.1007/s12265-024-10572-0","url":null,"abstract":"To assess the mechanical properties of small intestinal submucosal extracellular matrix (SIS-ECM) iterations and choose the optimal version for evaluating functional geometrics after posterior mitral valve reconstruction. Four SIS-ECM versions (2- and 4-ply vacuum-pressed and lyophilized) underwent uniaxial tensile testing. A posterior mitral valve reconstruction patch was developed based on MRI scans (n = 5). Posterior mitral valve reconstruction using 2-ply vacuum-pressed SIS-ECM was performed (n = 7), and geometrics were evaluated using a modified left heart simulator. The vacuum-pressed iterations displayed superior maximum stress values compared to lyophilized (2-ply: median [IQR], 15.8 [15.2-19.0] vs 7.9 [7.3-8.3] MPa, p < 0.001; 4-ply: median (IQR), 15.8 -[14.6-22.0] vs 7.9 [7.6-8.4] MPa). All reconstructed valves were competent with preserved total leaflet area, but individual leaflet segment areas were redistributed. Posterior mitral valve reconstruction with our 2-ply vacuum-pressed SIS-ECM patch design was feasible in vitro. Further in vivo evaluation is warranted.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drp1 Promotes Macrophage M1 Polarization and Inflammatory Response in Autoimmune Myocarditis by Driving Mitochondrial Fission. Drp1 通过驱动线粒体分裂促进自身免疫性心肌炎中巨噬细胞 M1 的极化和炎症反应

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-10-10 DOI: 10.1007/s12265-024-10570-2

Lin Lin, Jin Wei, Jiahong Xue, Gang Fan, Wenjing Zhu, Yanhe Zhu, Ruiyun Wu

{"title":"Drp1 Promotes Macrophage M1 Polarization and Inflammatory Response in Autoimmune Myocarditis by Driving Mitochondrial Fission.","authors":"Lin Lin, Jin Wei, Jiahong Xue, Gang Fan, Wenjing Zhu, Yanhe Zhu, Ruiyun Wu","doi":"10.1007/s12265-024-10570-2","DOIUrl":"https://doi.org/10.1007/s12265-024-10570-2","url":null,"abstract":"Autoimmune myocarditis (AM) is characterized by an intricate inflammatory response within the myocardium. Dynamin-related protein 1 (Drp1), a pivotal modulator of mitochondrial fission, plays a role in the pathogenesis of various diseases. A myosin-induced experimental autoimmune myocarditis (EAM) mouse model was successfully established. Flow cytometry was employed to detect M1/M2-like macrophages. Mitochondrial fragmentation was assessed using Mito-Tracker Red CMXRos. Drp1 was upregulated and activated in EAM mice. Depletion of Drp1 was observed to mitigate inflammation, macrophage infiltration and M1 polarization within the cardiac tissue of EAM mice. In M1-like macrophages derived from the hearts of EAM mice, Drp1 was found to promote mitochondrial fission and diminish mitochondrial fusion. Furthermore, the depletion of Drp1 reduced the NF-κB-related pro-inflammatory response in EAM-associated M1-like macrophages. Drp1 drives mitochondrial fission in macrophages, driving their M1 polarization and the subsequent inflammatory response. Drp1 may represent an effective target for the prevention and treatment of AM.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating Extracellular Vesicles from Heart Failure Patients Inhibit Human Cardiomyocyte Activities. 心衰患者的循环细胞外囊泡抑制人类心肌细胞的活动

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-10-09 DOI: 10.1007/s12265-024-10571-1

Ke Zhen, Xiaojuan Wei, Zelun Zhi, Shiyu Shang, Shuyan Zhang, Yilu Xu, Xiaochuan Fu, Linjia Cheng, Jing Yao, Yue Li, Xia Chen, Pingsheng Liu, Hongchao Zhang

{"title":"Circulating Extracellular Vesicles from Heart Failure Patients Inhibit Human Cardiomyocyte Activities.","authors":"Ke Zhen, Xiaojuan Wei, Zelun Zhi, Shiyu Shang, Shuyan Zhang, Yilu Xu, Xiaochuan Fu, Linjia Cheng, Jing Yao, Yue Li, Xia Chen, Pingsheng Liu, Hongchao Zhang","doi":"10.1007/s12265-024-10571-1","DOIUrl":"https://doi.org/10.1007/s12265-024-10571-1","url":null,"abstract":"Extracellular vesicles (EVs) have been implicated in cardiac remodeling during heart failure (HF). However, the role of circulating EVs (CEVs) in the process of HF is poorly understood. To elucidate the molecular mechanism associated with CEVs in the context of HF, the proteome of 4D label-free EVs from plasma samples was identified. Among the identified proteins, 6 exhibited upregulation while 9 demonstrated downregulation in CEVs derived from HF patients (HCEVs) compared to healthy controls (NCEVs). Our results showed that up-regulated proteins mainly participate in the primary metabolic, glycerolipid metabolic processes, oxidation-reduction process, and inflammatory amplification. In contrast, the down-regulated proteins influenced cell development, differentiation, and proliferation. Compared to NCEVs, HCEVs significantly induced inflammation and triacylglycerol (TAG) accumulation in human cardiomyocytes (HCMs) in vitro. They also compromised their regenerative capacities, triggered endoplasmic reticulum (ER) stress and increased autophagy in HCMs. Further, HCEVs induced differentiation of human cardiac fibroblasts (HCFs), amplifying pro-inflammatory, and pro-fibrotic factors, and enhancing extracellular matrix deposition. Notably, HCEVs are also associated with an increase in the HF biomarker MMP9 within HCFs and demonstrate a negative correlation with autophagic flux. In conclusion, HCEVs appear pivotal in advancing HF via pathological cardiac remodeling.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142390828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolated Perfused Hearts for Cardiovascular Research: An Old Dog with New Tricks. 用于心血管研究的离体灌注心：老狗出新招

IF 4.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-10-01 Epub Date: 2024-05-08 DOI: 10.1007/s12265-024-10517-7

Tianshuo Yang, Zirui Liu, Songren Shu, Zhice Chen, Xiumeng Hua, Jiangping Song

引用次数: 0

Differential Expression of mRNA in Peripheral Blood Mononuclear Cells May Predict Postoperative Atrial Fibrillation in Coronary Artery Bypass Surgery Patients. 外周血单核细胞中 mRNA 的差异表达可预测冠状动脉搭桥手术患者术后心房颤动的发生。

IF 4.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-10-01 Epub Date: 2024-07-15 DOI: 10.1007/s12265-024-10524-8

Mingqi Tan, Xiankun Liu, Lianqun Wang, Nan Jiang, Yunpeng Bai, Zhigang Guo

引用次数: 0

A Novel Prediction Model for Post-TAVI MACCE Based on Extracellular Vesicles Concentration Analysis. 基于细胞外囊泡浓度分析的新型 TAVI 术后 MACCE 预测模型

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-10-01 Epub Date: 2024-07-19 DOI: 10.1007/s12265-024-10538-2

Shuqin Liu, Michail Spanos, Jing Wang, Junjie Xiao

引用次数: 0

Pentraxin 3 in Myocarditis: Proof-of-Principle Assessment as a Diagnostic and Prognostic Biomarker. 心肌炎中的五毒素 3：作为诊断和预后生物标志物的原理性评估

IF 4.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-10-01 Epub Date: 2024-03-28 DOI: 10.1007/s12265-024-10506-w

Andrea Villatore, Antonella Monno, Clara Sciorati, Patrizia Rovere-Querini, Simone Sala, Davide Carino, Michele De Bonis, Domenico Cianflone, Angelo A Manfredi, Giovanni Peretto

{"title":"Pentraxin 3 in Myocarditis: Proof-of-Principle Assessment as a Diagnostic and Prognostic Biomarker.","authors":"Andrea Villatore, Antonella Monno, Clara Sciorati, Patrizia Rovere-Querini, Simone Sala, Davide Carino, Michele De Bonis, Domenico Cianflone, Angelo A Manfredi, Giovanni Peretto","doi":"10.1007/s12265-024-10506-w","DOIUrl":"10.1007/s12265-024-10506-w","url":null,"abstract":"Pentraxin 3 (PTX3) is an acute phase protein produced in various tissues in response to microbial and sterile stimuli, which regulates the inflammation outcomes. PTX3 has not been investigated in myocarditis. Our aim was to assess circulating and cardiac tissue expression of PTX3 in 55 patients with myocarditis proven by magnetic resonance and/or endomyocardial biopsy. A major proportion of patients with myocarditis displayed significantly increased plasma PTX3 levels as compared with controls (26/30 vs. 0/10), with higher diagnostic yield than conventional biomarkers in the study group. Cardiac tissue analysis revealed PTX3 expression in all patients (40/40), with viral myocarditis exhibiting higher signal intensity than autoimmune myocarditis, and with a predominant localization in cardiomyocytes. Abnormal plasma PTX3 was associated with systolic dysfunction and heart failure at presentation. Interestingly, patients who recovered by 12 months had higher baseline PTX3 levels. Our preliminary data support the potential use of PTX3 as a biomarker in myocarditis.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"1048-1058"},"PeriodicalIF":4.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140318365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0