Journal of Cardiovascular Translational Research最新文献_第8页

Correction: AIM2 Deficiency Alleviates Cardiac Inflammation and Hypertrophy in HFD/STZ-Induced Diabetic Mice by Inhibiting the NLRC4/IRF1 Signaling Pathway. 更正：AIM2缺乏通过抑制NLRC4/IRF1信号通路减轻HFD/ stz诱导的糖尿病小鼠心脏炎症和肥厚。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-04-01 DOI: 10.1007/s12265-024-10582-y

Jian-Ping Wu, Cheng Wu, Yuan-Ji Ma, Jian-Bing Zhu, Lei-Lei Ma, Fei-Juan Kong

引用次数: 0

Endothelial Cell-Derived Extracellular Vesicles Allow to Differentiate Between Various Endotypes of INOCA: A Multicentre, Prospective, Cohort Study. 内皮细胞来源的细胞外囊泡允许区分不同的内皮类型：一项多中心、前瞻性、队列研究。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-04-01 Epub Date: 2024-12-05 DOI: 10.1007/s12265-024-10575-x

Aleksandra Gąsecka, Piotr Szolc, Edwin van der Pol, Łukasz Niewiara, Bartłomiej Guzik, Paweł Kleczyński, Mariusz Tomaniak, Emilia Figura, Mateusz Zaremba, Marcin Grabowski, Janusz Kochman, Jacek Legutko, Łukasz Kołtowski

{"title":"Endothelial Cell-Derived Extracellular Vesicles Allow to Differentiate Between Various Endotypes of INOCA: A Multicentre, Prospective, Cohort Study.","authors":"Aleksandra Gąsecka, Piotr Szolc, Edwin van der Pol, Łukasz Niewiara, Bartłomiej Guzik, Paweł Kleczyński, Mariusz Tomaniak, Emilia Figura, Mateusz Zaremba, Marcin Grabowski, Janusz Kochman, Jacek Legutko, Łukasz Kołtowski","doi":"10.1007/s12265-024-10575-x","DOIUrl":"10.1007/s12265-024-10575-x","url":null,"abstract":"Ischemia and non-obstructive coronary artery disease (INOCA) might be due to coronary microvascular dysfunction (CMD), vasospastic angina (VSA) or both. We compared plasma concentration of various extracellular vesicles (EVs) in patients with different INOCA endotypes. Patients were divided into those with INOCA (CMD, VSA, mixed CMD + VSA) and non-anginal chest pain. Plasma concentrations of EVs were measured using flow cytometry. Out of 96 patients included, 34 had CMD (35%), 15 VSA (16%), 24 mixed endotype (25%) and 23 non-anginal chest pain (24%). Patients with INOCA had lower ratio of endothelial EVs (CD144 +) to total EVs, compared to patients with non-anginal pain (p = 0.027). Patients with mixed endotype had lower ratio of endothelial EVs (CD144 +) to total EVs, compared to CMD (p = 0.008), VSA (p = 0.014) and non-anginal pain (p < 0.001). Decreased ratio of endothelial EVs (CD144 +) to total EVs might serve as a \"circulating footprint\" of the mixed INOCA endotype.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"305-315"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyperspectral Imaging for Microcirculatory Assessment of Patients undergoing Transcatheter and Surgical Aortic Valve Replacement-a Prospective Observational Pilot Study. 用于经导管主动脉瓣置换术和外科主动脉瓣置换术患者微循环评估的高光谱成像--一项前瞻性观察试点研究。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-04-01 Epub Date: 2024-11-08 DOI: 10.1007/s12265-024-10573-z

Maximilian Dietrich, Aycan Tayan, Tobias Hölle, Christian Nusshag, Anne-Christine Kapp, Christina Mertens, Alexander Studier-Fischer, Felix Nickel, Florian Leuschner, Markus Alexander Weigand, Matthias Karck, Christoph Lichtenstern, Rawa Arif, Dania Fischer

{"title":"Hyperspectral Imaging for Microcirculatory Assessment of Patients undergoing Transcatheter and Surgical Aortic Valve Replacement-a Prospective Observational Pilot Study.","authors":"Maximilian Dietrich, Aycan Tayan, Tobias Hölle, Christian Nusshag, Anne-Christine Kapp, Christina Mertens, Alexander Studier-Fischer, Felix Nickel, Florian Leuschner, Markus Alexander Weigand, Matthias Karck, Christoph Lichtenstern, Rawa Arif, Dania Fischer","doi":"10.1007/s12265-024-10573-z","DOIUrl":"10.1007/s12265-024-10573-z","url":null,"abstract":"This prospective, observational study evaluated Hyperspectral Imaging (HSI) to assess the effects of cardiac surgery and cardiopulmonary bypass (CPB) on microcirculation. 40 Patients with severe aortic stenosis were enrolled. 20 patients underwent transapical/transaxillary/transaortic aortic valve replacement (TAVR), 20 underwent an open surgical approach with CPB (SAVR). HSI was used to determine tissue oxygenation (StO2 and NIR), hemoglobin (THI) and water content (TWI) at the palm before/after surgery (T1/T2), and on the third postoperative day (T3). TAVR patients showed no significant changes of microcirculatory parameters during surgery. TWI significantly increased until T3. SAVR patients showed an increase of TWI and a decrease of THI, while StO2 and NIR remained unchanged at T2. In SAVR patients, StO2 and NIR correlated negatively with the duration of CPB and StO2 correlated with intraoperative urine output at T2. HSI was able to detect microcirculatory changes during cardiac surgery. CPB duration seemed to affect tissue oxygenation. Clinical trial registration: (German Clinical Trial Register): DRKS00024765.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"295-304"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations of Blood Lipid-Related Polygenic Scores, Lifestyle Factors and Their Combined Effects with Risk of Coronary Artery Disease in the UK Biobank Cohort. 英国生物库队列中血脂相关多基因评分、生活方式因素及其综合效应与冠状动脉疾病风险的关系。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-04-01 Epub Date: 2024-12-16 DOI: 10.1007/s12265-024-10578-8

Jungyoon Choi, Wanqing Wen, Guochong Jia, Ran Tao, Jirong Long, Xiao-Ou Shu, Wei Zheng

引用次数: 0

Bufalin Ameliorates Myocardial Ischemia/Reperfusion Injury by Suppressing Macrophage Pyroptosis via P62 Pathway. 蟾毒灵通过P62途径抑制巨噬细胞焦亡改善心肌缺血再灌注损伤

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-04-01 Epub Date: 2024-12-28 DOI: 10.1007/s12265-024-10577-9

Chang Li, Zhen Ma, Xiang Wei, Ying Wang, Jian Wu, Xuan Li, Xiaolei Sun, Zhiwen Ding, Cheng Yang, Yunzeng Zou

{"title":"Bufalin Ameliorates Myocardial Ischemia/Reperfusion Injury by Suppressing Macrophage Pyroptosis via P62 Pathway.","authors":"Chang Li, Zhen Ma, Xiang Wei, Ying Wang, Jian Wu, Xuan Li, Xiaolei Sun, Zhiwen Ding, Cheng Yang, Yunzeng Zou","doi":"10.1007/s12265-024-10577-9","DOIUrl":"10.1007/s12265-024-10577-9","url":null,"abstract":"Bufalin, which is isolated from toad venom, exerts positive effects on hearts under pathological circumstance. We aimed to investigate the effects and mechanisms of bufalin on myocardial I/R injury. In vivo, bufalin ameliorated myocardial I/R injury, which characteristics with better ejection function, decreased infarct size and less apoptosis. The levels of pyroptotic proteins were increased in I/R-treated macrophages and inflammatory cytokines expressed more in I/R-induced mouse, which could be attenuated by bufalin. Bufalin also reduced H/R-treated macrophage pyroptosis in vitro. Autophagic flux blockage and ROS accumulation were reduced by bufalin in impaired macrophages. Overexpression of p62 abrogated the anti-proptosis and anti-oxidative effects of bufalin. The levels of apoptosis related proteins were changed and TUNEL-positive ratio was raised in cardiomyocytes that received conditioned medium treatment with H/R-treated macrophages, while bufalin pretreatment could reduce apoptosis. These findings indicate that bufalin may attenuate myocardial I/R injury by suppressing macrophage pyroptosis via P62 pathway.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"221-236"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-04-01 Epub Date: 2025-01-09 DOI: 10.1007/s12265-024-10583-x

Xing-Jie Wang, Lei Huang, Min Hou, Jie Guo

引用次数: 0

Prediction of Major Adverse Limb Events in Females with Peripheral Artery Disease using Blood-Based Biomarkers and Clinical Features. 利用基于血液的生物标志物和临床特征预测女性外周动脉疾病的主要肢体不良事件

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-04-01 Epub Date: 2024-12-06 DOI: 10.1007/s12265-024-10574-y

Ben Li, Hamzah Khan, Farah Shaikh, Abdelrahman Zamzam, Rawand Abdin, Mohammad Qadura

{"title":"Prediction of Major Adverse Limb Events in Females with Peripheral Artery Disease using Blood-Based Biomarkers and Clinical Features.","authors":"Ben Li, Hamzah Khan, Farah Shaikh, Abdelrahman Zamzam, Rawand Abdin, Mohammad Qadura","doi":"10.1007/s12265-024-10574-y","DOIUrl":"10.1007/s12265-024-10574-y","url":null,"abstract":"The objective of this study was to identify a female-specific prognostic biomarker for peripheral artery disease (PAD) and develop a prediction model for 2-year major adverse limb events (MALE). Patients with/without PAD were recruited (n=461). Plasma concentrations of 68 circulating proteins were measured and patients were followed for 2 years. The primary outcome was MALE (composite of vascular intervention, major amputation, or acute/chronic limb threatening ischemia). We trained a random forest model using: 1) clinical characteristics, 2) female-specific PAD biomarker, and 3) clinical characteristics and female-specific PAD biomarker. Galectin-9 was the only protein to be significantly elevated in females compared to males in the discovery/validation analyses. The random forest model achieved the following AUROC's: 0.72 (clinical features), 0.83 (Galectin-9), and 0.86 (clinical features + Galectin-9). We identified Galectin-9 as a female-specific PAD biomarker and developed an accurate prognostic model for 2-year MALE using a combination of clinical features and plasma Galectin-9 levels.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"316-330"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting Lactic Acid Modification in Ischemic Heart Diseases: Novel Therapeutics and Mechanism. 靶向乳酸修饰治疗缺血性心脏病：新疗法及机制

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-04-01 Epub Date: 2025-02-07 DOI: 10.1007/s12265-025-10593-3

Tangjiang Wan, Yucheng Liang, Tianwen Wei, Zijie Chen, Yafei Li

引用次数: 0

The link between ferroptosis and autophagy in myocardial ischemia/reperfusion injury: new directions for therapy. 心肌缺血/再灌注损伤中铁下垂与自噬的关系：新的治疗方向。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-04-01 Epub Date: 2025-01-30 DOI: 10.1007/s12265-025-10590-6

Xiaoting Yang, Hui Wu, Di Liu, Gang Zhou, Dong Zhang, Qingzhuo Yang, Yanfang Liu, Yi Li

引用次数: 0

RNA Therapies in Cardio-Kidney-Metabolic Syndrome: Advancing Disease Management. 心肾代谢综合征的RNA治疗：推进疾病管理。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2025-03-13 DOI: 10.1007/s12265-025-10603-4

Abbas Mohammadi, Azin Karimian, Kasra Shokri, Ashkan Mohammadi, Nazanin Hazhir-Karzar, Rayeheh Bahar, Azar Radfar, Mohammadreza Pakyari, Behnam Tehrani

{"title":"RNA Therapies in Cardio-Kidney-Metabolic Syndrome: Advancing Disease Management.","authors":"Abbas Mohammadi, Azin Karimian, Kasra Shokri, Ashkan Mohammadi, Nazanin Hazhir-Karzar, Rayeheh Bahar, Azar Radfar, Mohammadreza Pakyari, Behnam Tehrani","doi":"10.1007/s12265-025-10603-4","DOIUrl":"https://doi.org/10.1007/s12265-025-10603-4","url":null,"abstract":"Cardio-Kidney-Metabolic (CKM) Syndrome involves metabolic, kidney, and cardiovascular dysfunction, disproportionately affecting disadvantaged groups. Its staging (0-4) highlights the importance of early intervention. While current management targets hypertension, heart failure, dyslipidemia, and diabetes, RNA-based therapies offer innovative solutions by addressing molecular mechanisms of CKM Syndrome. Emerging RNA treatments, including antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs), show promise in slowing disease progression across CKM stages. For example, ASOs and siRNAs targeting ApoC-III and ANGPTL3 reduce triglycerides and LDL cholesterol, while siRNAs improve blood pressure control by targeting the renin-angiotensin-aldosterone system. Obesity treatments leveraging miRNAs and circRNAs tackle a key CKM risk factor. In heart failure and diabetes, RNA-based therapies improve cardiac function and glucose control, while early kidney disease trials show potential for RNAi in acute injury. Further research is essential to refine these therapies and ensure equitable access.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0