Journal of Cardiovascular Translational Research最新文献_第8页

Impact of Perivascular Adipose Tissue on Neointimal Formation Following Endovascular Placement. 血管周围脂肪组织对血管内置入后新内膜形成的影响

IF 4.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-08-01 Epub Date: 2024-02-26 DOI: 10.1007/s12265-024-10502-0

Belay Tesfamariam

引用次数: 0

Efficient Edge-AI Models for Robust ECG Abnormality Detection on Resource-Constrained Hardware. 在资源有限的硬件上利用高效边缘人工智能模型进行稳健的心电图异常检测

IF 4.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-08-01 Epub Date: 2024-03-12 DOI: 10.1007/s12265-024-10504-y

Zhaojing Huang, Luis Fernando Herbozo Contreras, Wing Hang Leung, Leping Yu, Nhan Duy Truong, Armin Nikpour, Omid Kavehei

{"title":"Efficient Edge-AI Models for Robust ECG Abnormality Detection on Resource-Constrained Hardware.","authors":"Zhaojing Huang, Luis Fernando Herbozo Contreras, Wing Hang Leung, Leping Yu, Nhan Duy Truong, Armin Nikpour, Omid Kavehei","doi":"10.1007/s12265-024-10504-y","DOIUrl":"10.1007/s12265-024-10504-y","url":null,"abstract":"This study introduces two models, ConvLSTM2D-liquid time-constant network (CLTC) and ConvLSTM2D-closed-form continuous-time neural network (CCfC), designed for abnormality identification using electrocardiogram (ECG) data. Trained on the Telehealth Network of Minas Gerais (TNMG) subset dataset, both models were evaluated for their performance, generalizability capacity, and resilience. They demonstrated comparable results in terms of F1 scores and AUROC values. The CCfC model achieved slightly higher accuracy, while the CLTC model showed better handling of empty channels. Remarkably, the models were successfully deployed on a resource-constrained microcontroller, proving their suitability for edge device applications. Generalization capabilities were confirmed through the evaluation on the China Physiological Signal Challenge 2018 (CPSC) dataset. The models' efficient resource utilization, occupying 70.6% of memory and 9.4% of flash memory, makes them promising candidates for real-world healthcare applications. Overall, this research advances abnormality identification in ECG data, contributing to the progress of AI in healthcare.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"879-892"},"PeriodicalIF":4.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11371854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140110356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myocardial Involvement after SARS-CoV-2 Vaccination in Asymptomatic Adolescents: Correspondence. 无症状青少年接种 SARS-CoV-2 疫苗后心肌受累：通信。

IF 4.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-08-01 Epub Date: 2024-02-13 DOI: 10.1007/s12265-024-10494-x

Hinpetch Daungsupawong, Viroj Wiwanitkit

引用次数: 0

CD137 Signaling Mediates Pulmonary Artery Endothelial Cell Proliferation Under Hypoxia By Regulating Mitochondrial Dynamics. CD137 信号通过调节线粒体动力学介导缺氧条件下肺动脉内皮细胞增殖

IF 4.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-08-01 Epub Date: 2024-02-12 DOI: 10.1007/s12265-024-10493-y

Hao Xia, Junying Duan, Mei Li, Nan Chen, Wei Zhong, Ye Zhou, Rui Chen, Wei Yuan

{"title":"CD137 Signaling Mediates Pulmonary Artery Endothelial Cell Proliferation Under Hypoxia By Regulating Mitochondrial Dynamics.","authors":"Hao Xia, Junying Duan, Mei Li, Nan Chen, Wei Zhong, Ye Zhou, Rui Chen, Wei Yuan","doi":"10.1007/s12265-024-10493-y","DOIUrl":"10.1007/s12265-024-10493-y","url":null,"abstract":"Altered mitochondrial dynamics affect pulmonary artery endothelial cells (PAECs) proliferation, contributing to the development of pulmonary hypertension. CD137 signaling promotes mitochondrial fission. We hypothesize CD137 signaling is involved in the excessive proliferation of PAECs. The levels of CD137 protein were increased in the lung tissue of hypoxic mice and hypoxic-stimulated PAECs. Activation of CD137 signal in hypoxic-PAECs upregulated the levels of hypoxia-inducible factor-2α (HIF-2α), glucose transporters type 4, the lactate transporter monocarboxylate transporter 4, key glycolysis rate-limiting enzymes and promoted mitochondrial division; moreover, increased glucose uptake, lactic acid and ATP production and proliferative cells were observed in these PAECs. Whereas, knockdown HIF-2α reversed CD137 signal-mediated effects in PAECs mentioned above. Compared with wild-type mice, the proliferation of PAECs and the percentage of vascular lateral wall thickness decreased in CD137 knockout mice. Together, CD137 signal participated in pulmonary vascular remodeling through the regulation of mitochondrial dynamics dependent on HIF-2α in PAECs.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"859-869"},"PeriodicalIF":4.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139722800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Allograft Model of Aortic Arch Segment Grafting to Abdominal Aorta Through End-to-Side Anastomosis in Mice. 通过端侧吻合将主动脉弓段移植到腹主动脉的小鼠同种异体移植模型。

IF 4.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-08-01 Epub Date: 2024-02-26 DOI: 10.1007/s12265-024-10495-w

Chiyu Liu, Qi Chen, Mingyuan He, Yulin Liao

{"title":"Allograft Model of Aortic Arch Segment Grafting to Abdominal Aorta Through End-to-Side Anastomosis in Mice.","authors":"Chiyu Liu, Qi Chen, Mingyuan He, Yulin Liao","doi":"10.1007/s12265-024-10495-w","DOIUrl":"10.1007/s12265-024-10495-w","url":null,"abstract":"The mouse aortic transplantation model is a valuable tool for investigating the mechanisms of atherosclerosis regression, but few laboratories can generate it due to the operation difficulty, especially for the style of end-to-side anastomosis, which facilitates syngeneic heterotopic transplanting a plaque-rich aortic arch into the abdominal aorta. Here we provide a modified protocol for generating this allograft model, which is capable of overcoming several critical surgical challenges such as separating a longer abdominal aorta segment, reducing bleeding and thrombosis, optimizing aortotomy, and improving end-to-side anastomosis to guarantee a potent graft. By transplanting plaque-rich aortic arches into the abdominal aorta of wildtype mice, a high operation success rate (over 90%) was noted with aortic clamping time under 60 min, the graft potency was satisfactory evidenced by examinations of micro-CT, ultrasound, and lower limb blood flow measurement, while a significant atherosclerosis regression was observed in the grafts at 1 week after transplantation.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"901-909"},"PeriodicalIF":4.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11371875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139972026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to Correspondence on "Absence of Myocardial Involvement after SARS-CoV-2 Vaccination in Asymptomatic Adolescents". 对有关 "无症状青少年接种 SARS-CoV-2 疫苗后心肌未受感染 "的来函的答复

IF 4.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-08-01 Epub Date: 2024-02-13 DOI: 10.1007/s12265-024-10492-z

Rocío Párraga, Carlos Real, Rodrigo Fernández-Jiménez

引用次数: 0

Association Between Automated 3D Measurement of Coronary Luminal Narrowing and Risk of Future Myocardial Infarction. 冠状动脉管腔狭窄自动三维测量与未来心肌梗死风险之间的关系

IF 4.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-08-01 Epub Date: 2024-03-01 DOI: 10.1007/s12265-024-10500-2

Alessandro Candreva, Maurizio Lodi Rizzini, Karol Calò, Mattia Pagnoni, Daniel Munhoz, Claudio Chiastra, Jean-Paul Aben, Stephane Fournier, Olivier Muller, Bernard De Bruyne, Carlos Collet, Diego Gallo, Umberto Morbiducci

{"title":"Association Between Automated 3D Measurement of Coronary Luminal Narrowing and Risk of Future Myocardial Infarction.","authors":"Alessandro Candreva, Maurizio Lodi Rizzini, Karol Calò, Mattia Pagnoni, Daniel Munhoz, Claudio Chiastra, Jean-Paul Aben, Stephane Fournier, Olivier Muller, Bernard De Bruyne, Carlos Collet, Diego Gallo, Umberto Morbiducci","doi":"10.1007/s12265-024-10500-2","DOIUrl":"10.1007/s12265-024-10500-2","url":null,"abstract":"This study focuses on identifying anatomical markers with predictive capacity for long-term myocardial infarction (MI) in focal coronary artery disease (CAD). Eighty future culprit lesions (FCL) and 108 non-culprit lesions (NCL) from 80 patients underwent 3D quantitative coronary angiography. The minimum lumen area (MLA), minimum lumen ratio (MLR), and vessel fractional flow reserve (vFFR) were evaluated. MLR was defined as the ratio between MLA and the cross-sectional area at the proximal lesion edge, with lower values indicating more abrupt luminal narrowing. Significant differences were observed between FCL and NCL in MLR (0.41 vs. 0.53, p < 0.001). MLR correlated inversely with translesional vFFR (r = - 0.26, p = 0.0004) and was the strongest predictor of MI at 5 years (AUC = 0.75). Lesions with MLR < 0.40 had a fourfold increased MI incidence at 5 years. MLR is a robust predictor of future adverse coronary events.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"893-900"},"PeriodicalIF":4.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11371893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139996326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipoamide Attenuates Hypertensive Myocardial Hypertrophy Through PI3K/Akt-Mediated Nrf2 Signaling Pathway. 脂酰胺通过PI3K/Akt介导的Nrf2信号通路减轻高血压性心肌肥厚

IF 4.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-08-01 Epub Date: 2024-02-09 DOI: 10.1007/s12265-024-10488-9

Hongjuan Cao, Lina Zhao, Yao Yuan, Chunyan Liao, Weidan Zeng, Aiyue Li, Quanfeng Huang, Yueyao Zhao, Yubing Fan, Liu Jiang, Dandan Song, Sha Li, Bei Zhang

{"title":"Lipoamide Attenuates Hypertensive Myocardial Hypertrophy Through PI3K/Akt-Mediated Nrf2 Signaling Pathway.","authors":"Hongjuan Cao, Lina Zhao, Yao Yuan, Chunyan Liao, Weidan Zeng, Aiyue Li, Quanfeng Huang, Yueyao Zhao, Yubing Fan, Liu Jiang, Dandan Song, Sha Li, Bei Zhang","doi":"10.1007/s12265-024-10488-9","DOIUrl":"10.1007/s12265-024-10488-9","url":null,"abstract":"The process of myocardial hypertrophy in hypertension can lead to excessive activation of oxidative stress. Lipoamide (ALM) has significant antioxidant and anti-inflammatory effects. This study aimed to investigate the effects of ALM on hypertension-induced cardiac hypertrophy, as well as explore its underlying mechanisms. We evaluated the effects of ALM on spontaneously hypertensive rats and rat cardiomyocytes treated with Ang II. We found that ALM was not effective in lowering blood pressure in SHR, but it attenuated hypertension-mediated cardiac fibrosis, oxidative stress, inflammation, and hypertrophy in rats. After that, in cultured H9C2 cells stimulated with Ang II, ALM increased the expression of antioxidant proteins that were decreased in the Ang II group. ALM also alleviated cell hypertrophy and the accumulation of ROS, while LY294002 partially abrogated these effects. Collectively, these results demonstrate that ALM could alleviate oxidative stress in cardiac hypertrophy, potentially through the activation of the PI3K/Akt-mediated Nrf2 signaling pathway.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"910-922"},"PeriodicalIF":4.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11371882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139706852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mzb1 Attenuates Atherosclerotic Plaque Vulnerability in ApoE-/- Mice by Alleviating Apoptosis and Modulating Mitochondrial Function. Mzb1通过缓解细胞凋亡和调节线粒体功能减轻载脂蛋白E-/-小鼠动脉粥样硬化斑块的脆弱性

IF 4.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-08-01 Epub Date: 2024-01-31 DOI: 10.1007/s12265-024-10483-0

Guanglang Zhu, Yang Li, Hongxia Gao, Xu Li, Heyu Fan, Longhua Fan

{"title":"Mzb1 Attenuates Atherosclerotic Plaque Vulnerability in ApoE-/- Mice by Alleviating Apoptosis and Modulating Mitochondrial Function.","authors":"Guanglang Zhu, Yang Li, Hongxia Gao, Xu Li, Heyu Fan, Longhua Fan","doi":"10.1007/s12265-024-10483-0","DOIUrl":"10.1007/s12265-024-10483-0","url":null,"abstract":"In this study, we investigated the protective role of Mzb1 in atherosclerotic plaque vulnerability. To explore the impact of Mzb1, we analyzed Mzb1 expression, assessed apoptosis, and evaluated mitochondrial function in atherosclerosis (AS) mouse models and human vascular smooth muscle cells (HVSMCs). We observed a significant decrease in Mzb1 expression in AS mouse models and ox-LDL-treated HVSMCs. Downregulation of Mzb1 increased ox-LDL-induced apoptosis and cholesterol levels of HVSMCs, while Mzb1 overexpression alleviated these effect. Mzb1 was found to enhance mitochondrial function, as evidenced by restored ATP synthesis, mitochondrial membrane potential, and reduced mtROS production. Moreover, Mzb1 overexpression attenuated atherosclerotic plaque vulnerability in ApoE-/- mice. Our findings suggest that Mzb1 overexpression regulates the AMPK/SIRT1 signaling pathway, leading to the attenuation of atherosclerotic plaque vulnerability. This study provides compelling evidence for the protective effect of Mzb1 on atherosclerotic plaques by alleviating apoptosis and modulating mitochondrial function in ApoE-/- mice.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"782-794"},"PeriodicalIF":4.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139642210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Strategies for Angiogenesis Based on Endothelial Cell Epigenetics. 基于内皮细胞表观遗传学的血管生成治疗策略。

IF 4.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-08-01 Epub Date: 2024-01-31 DOI: 10.1007/s12265-024-10485-y

Yue Cai, Lihua Li, Chen Shao, Yiliu Chen, Zhongqun Wang

引用次数: 0