Journal of Cardiovascular Translational Research最新文献_第8页

Novel Genetic Variants Associated with Primary Myocardial Fibrosis in Sudden Cardiac Death Victims. 与心脏性猝死患者原发性心肌纤维化有关的新型基因变异。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-12-01 Epub Date: 2024-06-07 DOI: 10.1007/s12265-024-10527-5

Sini Skarp, Anne Doedens, Lauri Holmström, Valerio Izzi, Samu Saarimäki, Eeva Sliz, Johannes Kettunen, Lasse Pakanen, Risto Kerkelä, Katri Pylkäs, Heikki V Huikuri, Robert J Myerburg, Juhani Junttila

{"title":"Novel Genetic Variants Associated with Primary Myocardial Fibrosis in Sudden Cardiac Death Victims.","authors":"Sini Skarp, Anne Doedens, Lauri Holmström, Valerio Izzi, Samu Saarimäki, Eeva Sliz, Johannes Kettunen, Lasse Pakanen, Risto Kerkelä, Katri Pylkäs, Heikki V Huikuri, Robert J Myerburg, Juhani Junttila","doi":"10.1007/s12265-024-10527-5","DOIUrl":"10.1007/s12265-024-10527-5","url":null,"abstract":"Myocardial fibrosis is a common finding in victims of sudden cardiac death (SCD). Whole exome sequencing was performed in 127 victims of SCD with primary myocardial fibrosis as the only pathological finding. These cases are derived from the Fingesture study which has collected data from autopsy-verified SCD victims in Northern Finland. A computational approach was used to identify protein interactions in cardiomyocytes. Associations of the identified variants with cardiac disease endpoints were investigated in the Finnish national genetic study (FinnGen) dataset. We identified 21 missense and one nonsense variant. Four variants were estimated to affect protein function, significantly associated with SCD/primary myocardial fibrosis (Fingesture) and associated with cardiac diseases in Finnish population (FinnGen). These variants locate in cartilage acidic protein 1 (CRATC1), calpain 1 (CAPN1), unc-45 myosin chaperone A (UNC45A) and unc-45 myosin chaperone B (UNC45B). The variants identified contribute to function of extracellular matrix and cardiomyocytes.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"1229-1239"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141283833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphological Features of the Vertebrobasilar System Predict Ischemic Stroke Risk in Spontaneous Vertebral Artery Dissection. 椎基底动脉系统的形态特征可预测自发性椎动脉夹层的缺血性中风风险

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-12-01 Epub Date: 2024-07-09 DOI: 10.1007/s12265-024-10534-6

Jiajia Bao, Mateng Bai, Muke Zhou, Jinghuan Fang, Yanbo Li, Jian Guo, Li He

{"title":"Morphological Features of the Vertebrobasilar System Predict Ischemic Stroke Risk in Spontaneous Vertebral Artery Dissection.","authors":"Jiajia Bao, Mateng Bai, Muke Zhou, Jinghuan Fang, Yanbo Li, Jian Guo, Li He","doi":"10.1007/s12265-024-10534-6","DOIUrl":"10.1007/s12265-024-10534-6","url":null,"abstract":"The vertebral artery's morphological characteristics are crucial in spontaneous vertebral artery dissection (sVAD). We aimed to investigate morphologic features related to ischemic stroke (IS) and develop a novel prediction model. Out of 126 patients, 93 were finally analyzed. We constructed 3D models and morphological analyses. Patients were randomly classified into training and validation cohorts (3:1 ratio). Variables selected by LASSO - including five morphological features and five clinical characteristics - were used to develop prediction model in the training cohort. The model exhibited a high area under the curve (AUC) of 0.944 (95%CI, 0.862-0.984), with internal validation confirming its consistency (AUC = 0.818, 95%CI, 0.597-0.948). Decision curve analysis (DCA) indicated clinical usefulness. Morphological features significantly contribute to risk stratification in sVAD patients. Our novel developed model, combining interdisciplinary parameters, is clinically useful for predicting IS risk. Further validation and in-depth research into the hemodynamics related to sVAD are necessary.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"1365-1376"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141558845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-intensity Focused Ultrasound-A New Choice to Conduct Pulmonary Artery Denervation. 高强度聚焦超声--进行肺动脉去神经支配的新选择

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-12-01 Epub Date: 2024-07-06 DOI: 10.1007/s12265-024-10531-9

Yonghui Xie, Taoyue Yao, Xiaogang Zhu, Fan Yang, Haoqin Fan, Shirui Cao, Huaiyang Chen, Manzhen Liao, Yuanxi Xia, Jinqiao Liu, Zhenghui Xiao, Zhou Yang, Yunbin Xiao

{"title":"High-intensity Focused Ultrasound-A New Choice to Conduct Pulmonary Artery Denervation.","authors":"Yonghui Xie, Taoyue Yao, Xiaogang Zhu, Fan Yang, Haoqin Fan, Shirui Cao, Huaiyang Chen, Manzhen Liao, Yuanxi Xia, Jinqiao Liu, Zhenghui Xiao, Zhou Yang, Yunbin Xiao","doi":"10.1007/s12265-024-10531-9","DOIUrl":"10.1007/s12265-024-10531-9","url":null,"abstract":"This research aimed to explore whether high-intensity focused ultrasound (HIFU) could conduct pulmonary artery denervation (PADN). HIFU was performed in pulmonary arteries of 6 normotensive rabbits at dose of 250W, 6 times for each rabbit, and an additional 6 rabbits served as controls. Then ATEPH was induced in both groups by intravenous infusion of autogeneic thrombus. Hemodynamics and ultrasonography parameters were measured by right heart catheter and echocardiography pre- and post-establishment of ATEPH models in both groups. Histological analysis and immunohistochemistry of tyrosine hydroxylase (TH) were also performed. After PADN procedures, 5 rabbits were successfully conducted PADN, of which ablation zone was also observed in right auricle or right lung in 4 rabbits. Ablation zone was detected only in right lung in 1 rabbit. Compared with control group, milder right heart hemodynamic changes were found in PADN group, accompanied by improved ultrasound parameters in PADN group. HIFU can acutly damage SNs around pulmonary artery successfully, which may be a new choice to conduct PADN. However, the accuracy of HIFU with PADN needs to be improved.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"1353-1364"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11635049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141544876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasma Biomarker Screening Based on Proteomic Signature of Patients with Resistant Hypertension. 基于难治性高血压患者蛋白质组特征的血浆生物标志物筛查

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-12-01 Epub Date: 2024-07-06 DOI: 10.1007/s12265-024-10541-7

Jianmin Du, Xiaoqian Yu, Wenyu Zhang, Xinghai Zhang, Hengli Zhao, Rui Xu, Qing Wen

引用次数: 0

Adult Cardiomyocyte-Derived Extracellular Vesicles: a Promising Therapy for Cardiac Fibrosis. 成人心肌细胞衍生的细胞外囊泡：一种治疗心脏纤维化的有效疗法

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-12-01 Epub Date: 2024-08-26 DOI: 10.1007/s12265-024-10554-2

Hongyun Wang, Xinpeng Li, Qianwen Wu, Wei Chen, Yihua Bei

引用次数: 0

Hyperspectral Imaging for Microcirculatory Assessment of Patients undergoing Transcatheter and Surgical Aortic Valve Replacement-a Prospective Observational Pilot Study. 用于经导管主动脉瓣置换术和外科主动脉瓣置换术患者微循环评估的高光谱成像--一项前瞻性观察试点研究。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-11-08 DOI: 10.1007/s12265-024-10573-z

Maximilian Dietrich, Aycan Tayan, Tobias Hölle, Christian Nusshag, Anne-Christine Kapp, Christina Mertens, Alexander Studier-Fischer, Felix Nickel, Florian Leuschner, Markus Alexander Weigand, Matthias Karck, Christoph Lichtenstern, Rawa Arif, Dania Fischer

{"title":"Hyperspectral Imaging for Microcirculatory Assessment of Patients undergoing Transcatheter and Surgical Aortic Valve Replacement-a Prospective Observational Pilot Study.","authors":"Maximilian Dietrich, Aycan Tayan, Tobias Hölle, Christian Nusshag, Anne-Christine Kapp, Christina Mertens, Alexander Studier-Fischer, Felix Nickel, Florian Leuschner, Markus Alexander Weigand, Matthias Karck, Christoph Lichtenstern, Rawa Arif, Dania Fischer","doi":"10.1007/s12265-024-10573-z","DOIUrl":"https://doi.org/10.1007/s12265-024-10573-z","url":null,"abstract":"This prospective, observational study evaluated Hyperspectral Imaging (HSI) to assess the effects of cardiac surgery and cardiopulmonary bypass (CPB) on microcirculation. 40 Patients with severe aortic stenosis were enrolled. 20 patients underwent transapical/transaxillary/transaortic aortic valve replacement (TAVR), 20 underwent an open surgical approach with CPB (SAVR). HSI was used to determine tissue oxygenation (StO2 and NIR), hemoglobin (THI) and water content (TWI) at the palm before/after surgery (T1/T2), and on the third postoperative day (T3). TAVR patients showed no significant changes of microcirculatory parameters during surgery. TWI significantly increased until T3. SAVR patients showed an increase of TWI and a decrease of THI, while StO2 and NIR remained unchanged at T2. In SAVR patients, StO2 and NIR correlated negatively with the duration of CPB and StO2 correlated with intraoperative urine output at T2. HSI was able to detect microcirculatory changes during cardiac surgery. CPB duration seemed to affect tissue oxygenation. Clinical trial registration: (German Clinical Trial Register): DRKS00024765.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical and Geometric Characterization of a Novel 2-Ply Vacuum-Pressed Biological Scaffold Patch Design for Posterior Mitral Valve Reconstruction. 用于二尖瓣后瓣重建的新型双层真空压制生物支架补片设计的机械和几何特性。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-10-28 DOI: 10.1007/s12265-024-10572-0

Johannes H Jedrzejczyk, Frederik T Andersen, Jacob Petersen, Alexander Emil Kaspersen, Urjosee Sahana, Søren N Skov, Jens T Væsel, J Michael Hasenkam, Marcell J Tjørnild

{"title":"Mechanical and Geometric Characterization of a Novel 2-Ply Vacuum-Pressed Biological Scaffold Patch Design for Posterior Mitral Valve Reconstruction.","authors":"Johannes H Jedrzejczyk, Frederik T Andersen, Jacob Petersen, Alexander Emil Kaspersen, Urjosee Sahana, Søren N Skov, Jens T Væsel, J Michael Hasenkam, Marcell J Tjørnild","doi":"10.1007/s12265-024-10572-0","DOIUrl":"https://doi.org/10.1007/s12265-024-10572-0","url":null,"abstract":"To assess the mechanical properties of small intestinal submucosal extracellular matrix (SIS-ECM) iterations and choose the optimal version for evaluating functional geometrics after posterior mitral valve reconstruction. Four SIS-ECM versions (2- and 4-ply vacuum-pressed and lyophilized) underwent uniaxial tensile testing. A posterior mitral valve reconstruction patch was developed based on MRI scans (n = 5). Posterior mitral valve reconstruction using 2-ply vacuum-pressed SIS-ECM was performed (n = 7), and geometrics were evaluated using a modified left heart simulator. The vacuum-pressed iterations displayed superior maximum stress values compared to lyophilized (2-ply: median [IQR], 15.8 [15.2-19.0] vs 7.9 [7.3-8.3] MPa, p < 0.001; 4-ply: median (IQR), 15.8 -[14.6-22.0] vs 7.9 [7.6-8.4] MPa). All reconstructed valves were competent with preserved total leaflet area, but individual leaflet segment areas were redistributed. Posterior mitral valve reconstruction with our 2-ply vacuum-pressed SIS-ECM patch design was feasible in vitro. Further in vivo evaluation is warranted.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drp1 Promotes Macrophage M1 Polarization and Inflammatory Response in Autoimmune Myocarditis by Driving Mitochondrial Fission. Drp1 通过驱动线粒体分裂促进自身免疫性心肌炎中巨噬细胞 M1 的极化和炎症反应

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-10-10 DOI: 10.1007/s12265-024-10570-2

Lin Lin, Jin Wei, Jiahong Xue, Gang Fan, Wenjing Zhu, Yanhe Zhu, Ruiyun Wu

{"title":"Drp1 Promotes Macrophage M1 Polarization and Inflammatory Response in Autoimmune Myocarditis by Driving Mitochondrial Fission.","authors":"Lin Lin, Jin Wei, Jiahong Xue, Gang Fan, Wenjing Zhu, Yanhe Zhu, Ruiyun Wu","doi":"10.1007/s12265-024-10570-2","DOIUrl":"https://doi.org/10.1007/s12265-024-10570-2","url":null,"abstract":"Autoimmune myocarditis (AM) is characterized by an intricate inflammatory response within the myocardium. Dynamin-related protein 1 (Drp1), a pivotal modulator of mitochondrial fission, plays a role in the pathogenesis of various diseases. A myosin-induced experimental autoimmune myocarditis (EAM) mouse model was successfully established. Flow cytometry was employed to detect M1/M2-like macrophages. Mitochondrial fragmentation was assessed using Mito-Tracker Red CMXRos. Drp1 was upregulated and activated in EAM mice. Depletion of Drp1 was observed to mitigate inflammation, macrophage infiltration and M1 polarization within the cardiac tissue of EAM mice. In M1-like macrophages derived from the hearts of EAM mice, Drp1 was found to promote mitochondrial fission and diminish mitochondrial fusion. Furthermore, the depletion of Drp1 reduced the NF-κB-related pro-inflammatory response in EAM-associated M1-like macrophages. Drp1 drives mitochondrial fission in macrophages, driving their M1 polarization and the subsequent inflammatory response. Drp1 may represent an effective target for the prevention and treatment of AM.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating Extracellular Vesicles from Heart Failure Patients Inhibit Human Cardiomyocyte Activities. 心衰患者的循环细胞外囊泡抑制人类心肌细胞的活动

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-10-09 DOI: 10.1007/s12265-024-10571-1

Ke Zhen, Xiaojuan Wei, Zelun Zhi, Shiyu Shang, Shuyan Zhang, Yilu Xu, Xiaochuan Fu, Linjia Cheng, Jing Yao, Yue Li, Xia Chen, Pingsheng Liu, Hongchao Zhang

{"title":"Circulating Extracellular Vesicles from Heart Failure Patients Inhibit Human Cardiomyocyte Activities.","authors":"Ke Zhen, Xiaojuan Wei, Zelun Zhi, Shiyu Shang, Shuyan Zhang, Yilu Xu, Xiaochuan Fu, Linjia Cheng, Jing Yao, Yue Li, Xia Chen, Pingsheng Liu, Hongchao Zhang","doi":"10.1007/s12265-024-10571-1","DOIUrl":"https://doi.org/10.1007/s12265-024-10571-1","url":null,"abstract":"Extracellular vesicles (EVs) have been implicated in cardiac remodeling during heart failure (HF). However, the role of circulating EVs (CEVs) in the process of HF is poorly understood. To elucidate the molecular mechanism associated with CEVs in the context of HF, the proteome of 4D label-free EVs from plasma samples was identified. Among the identified proteins, 6 exhibited upregulation while 9 demonstrated downregulation in CEVs derived from HF patients (HCEVs) compared to healthy controls (NCEVs). Our results showed that up-regulated proteins mainly participate in the primary metabolic, glycerolipid metabolic processes, oxidation-reduction process, and inflammatory amplification. In contrast, the down-regulated proteins influenced cell development, differentiation, and proliferation. Compared to NCEVs, HCEVs significantly induced inflammation and triacylglycerol (TAG) accumulation in human cardiomyocytes (HCMs) in vitro. They also compromised their regenerative capacities, triggered endoplasmic reticulum (ER) stress and increased autophagy in HCMs. Further, HCEVs induced differentiation of human cardiac fibroblasts (HCFs), amplifying pro-inflammatory, and pro-fibrotic factors, and enhancing extracellular matrix deposition. Notably, HCEVs are also associated with an increase in the HF biomarker MMP9 within HCFs and demonstrate a negative correlation with autophagic flux. In conclusion, HCEVs appear pivotal in advancing HF via pathological cardiac remodeling.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142390828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolated Perfused Hearts for Cardiovascular Research: An Old Dog with New Tricks. 用于心血管研究的离体灌注心：老狗出新招

IF 4.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-10-01 Epub Date: 2024-05-08 DOI: 10.1007/s12265-024-10517-7

Tianshuo Yang, Zirui Liu, Songren Shu, Zhice Chen, Xiumeng Hua, Jiangping Song

引用次数: 0