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Journal of Cardiovascular Translational Research最新文献

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A Systematic Review of Modeling Platforms for Atrioventricular Valves in Atrioventricular Septal Defects. 房室间隔缺损房室瓣膜建模平台的系统综述。
IF 2.6 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2026-06-18 DOI: 10.1007/s12265-026-10799-z
Chen Chia Wang, Murray Marx, Eric Barth, Antonio D'Amore, Haoxiang Luo, Garrett Coyan
{"title":"A Systematic Review of Modeling Platforms for Atrioventricular Valves in Atrioventricular Septal Defects.","authors":"Chen Chia Wang, Murray Marx, Eric Barth, Antonio D'Amore, Haoxiang Luo, Garrett Coyan","doi":"10.1007/s12265-026-10799-z","DOIUrl":"10.1007/s12265-026-10799-z","url":null,"abstract":"<p><p>Given the high rate of re-intervention in patients with atrioventricular septal defects (AVSD), there is a continuing need to accurately model the complex valve anatomy and surgical repair strategies. This systematic review examined the current scientific landscape for modeling platforms designed to study abnormal congenital heart valves that are used or could be used for AVSD investigation. Of 1,050 sources screened, 47 were included (14 in silico; 26 in vitro; 7 in vivo). In silico models studying valve pathologies have advanced in recent years, but few targeted AVSD valves. In vitro platforms allow comparisons of repair techniques, but have yet to be applied for AVSD valve repair. In vivo studies could offer physiologically accurate platforms, but face challenges such as replicating AVSD pathologies. Multidisciplinary approaches to creating high-fidelity, reproducible, physiologically accurate AVSD valve models can transform the understanding of AVSD valve properties and repair strategies.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":"19 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13279604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148277549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low-dose Empagliflozin Does Not Modify Myocardial Energetics and Function in a Large-animal Model of Hibernating Myocardium. 在冬眠心肌的大动物模型中，低剂量恩格列净不改变心肌能量和功能。
IF 2.6 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2026-06-18 DOI: 10.1007/s12265-026-10780-w
Danielle Medina-Hernández, Carlos Galán-Arriola, Pedro Luis Cepas, Daniel Pérez-Camargo, Laura Cádiz, Daniel Pereda, Javier Sánchez-González, Ana García-Alvarez, Borja Ibáñez
{"title":"Low-dose Empagliflozin Does Not Modify Myocardial Energetics and Function in a Large-animal Model of Hibernating Myocardium.","authors":"Danielle Medina-Hernández, Carlos Galán-Arriola, Pedro Luis Cepas, Daniel Pérez-Camargo, Laura Cádiz, Daniel Pereda, Javier Sánchez-González, Ana García-Alvarez, Borja Ibáñez","doi":"10.1007/s12265-026-10780-w","DOIUrl":"10.1007/s12265-026-10780-w","url":null,"abstract":"","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":"19 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148277574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting Ferroptosis and Pyroptosis in Cardiovascular Diseases: Mechanisms and Therapeutic Implication. 心血管疾病中的铁下垂和焦下垂：机制和治疗意义。
IF 2.6 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2026-06-13 DOI: 10.1007/s12265-026-10793-5
Wenjuan Zhang, Kexin Zhang, Wei Xu, Chengxia Kan, Xiaodong Sun, Ying Xue
{"title":"Targeting Ferroptosis and Pyroptosis in Cardiovascular Diseases: Mechanisms and Therapeutic Implication.","authors":"Wenjuan Zhang, Kexin Zhang, Wei Xu, Chengxia Kan, Xiaodong Sun, Ying Xue","doi":"10.1007/s12265-026-10793-5","DOIUrl":"10.1007/s12265-026-10793-5","url":null,"abstract":"<p><p>Cardiovascular diseases (CVDs) remain the leading global cause of morbidity and mortality. Lipid-lowering, anti-inflammatory, and antioxidant strategies improve clinical outcomes but only partly prevent cardiomyocyte loss and remodeling. Emerging evidence identifies ferroptosis, an iron-dependent lipid peroxidation pathway, and pyroptosis, an inflammasome-driven inflammatory cell-death program, as central drivers of myocardial injury, vascular dysfunction, and heart failure (HF) progression. These death modes are mechanistically interconnected: lipid peroxidation and mitochondrial ROS promote NLRP3 inflammasome activation, while gasdermin-mediated cytokine release disrupts iron homeostasis and accelerates oxidative injury. We synthesize current knowledge on ferroptosis-pyroptosis crosstalk in ischemia-reperfusion injury, HF, and atherosclerosis, emphasizing metabolic-immune coupling through GPX4, ACSL4, NLRP3, and GSDMD. We highlight natural products like quercetin, paeoniflorin, and curcumin as dual-pathway regulators, activating Nrf2-GPX4 and suppressing inflammasomes. Advancing ferroptosis-pyroptosis strategies needs clear intervention timing, better compound availability, and more translational research. Dual blockade of oxidative and inflammatory cell death offers promise for precise cardiovascular therapy.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":"19 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148251625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on "A MATLAB Algorithm to Automatically Estimate the QT Interval and Other ECG Parameters and Validation Using a Machine Learning Approach in Congenital Long-QT Syndrome". 对“先天性长QT综合征QT间期及其他心电图参数的MATLAB自动估计算法及机器学习方法验证”的评论
IF 2.6 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2026-06-12 DOI: 10.1007/s12265-026-10787-3
Santosh Mohanlal Modani, Abhishek Kumar Upadhyay, S R V Prasad Reddy
{"title":"Comment on \"A MATLAB Algorithm to Automatically Estimate the QT Interval and Other ECG Parameters and Validation Using a Machine Learning Approach in Congenital Long-QT Syndrome\".","authors":"Santosh Mohanlal Modani, Abhishek Kumar Upadhyay, S R V Prasad Reddy","doi":"10.1007/s12265-026-10787-3","DOIUrl":"10.1007/s12265-026-10787-3","url":null,"abstract":"","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":"19 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148239477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex-Specific Prospective Association of Serum Zinc Concentration with Cardiovascular Disease and Mortality: A 10-Year Population-Based Cohort Study. 血清锌浓度与心血管疾病和死亡率的性别特异性前瞻性关联：一项10年基于人群的队列研究
IF 2.6 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2026-06-09 DOI: 10.1007/s12265-026-10789-1
Fateme Ghafouri-Taleghani, Zahra Bahadoran, Fereidoun Azizi
{"title":"Sex-Specific Prospective Association of Serum Zinc Concentration with Cardiovascular Disease and Mortality: A 10-Year Population-Based Cohort Study.","authors":"Fateme Ghafouri-Taleghani, Zahra Bahadoran, Fereidoun Azizi","doi":"10.1007/s12265-026-10789-1","DOIUrl":"10.1007/s12265-026-10789-1","url":null,"abstract":"<p><p>Zinc is an essential trace element that plays a significant role in vascular function. This study aimed to investigate the potential association between serum zinc (SZn) concentration and cardiovascular disease (CVD) events, CVD mortality, and all-cause mortality, while also considering possible sex-specific differences. We analyzed data from 3,353 participants aged 30 years or older without a history of CVD, sourced from the fourth phase of the Tehran Lipid and Glucose Study (TLGS) conducted between 2009 and 2011. Multivariable Cox proportional hazard models were used. In men, low SZn levels were associated to a 94% increased risk of all-cause mortality (HR = 1.94, 95% CI = 1.03-3.65). Conversely, high SZn concentrations were associated with a reduced risk of CVD events (HR = 0.66, 95% CI = 0.46-0.93). No significant associations were observed in women. In men, low SZn was associated with higher all-cause mortality, whereas high SZn was inversely associated with CVD risk.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":"19 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148204894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Mechanisms and Clinical Applications of SGLT2 Inhibitors in Cardiovascular Diseases. SGLT2抑制剂在心血管疾病中的分子机制及临床应用
IF 2.6 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2026-06-08 DOI: 10.1007/s12265-026-10794-4
Cong Ma, Pangbo Yang, Rumeng Du, Simin Yang, Zhiwei Xu
{"title":"Molecular Mechanisms and Clinical Applications of SGLT2 Inhibitors in Cardiovascular Diseases.","authors":"Cong Ma, Pangbo Yang, Rumeng Du, Simin Yang, Zhiwei Xu","doi":"10.1007/s12265-026-10794-4","DOIUrl":"10.1007/s12265-026-10794-4","url":null,"abstract":"<p><p>Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have emerged as a vital therapy that bridges glycemic control and cardiovascular protection, fundamentally changing the way the Cardiovascular-Kidney-Metabolic (CKM) syndrome is managed. This review summarises the current evidence on the molecular mechanisms of SGLT2 inhibitors, ranging from haemodynamic regulation to metabolic reprogramming, and their clinical applications in various cardiovascular diseases. We critically discuss the pharmacological characteristics of different agents, as well as the debate surrounding glucose-dependent versus glucose-independent mechanisms. Furthermore, we summarise current guideline recommendations to provide clinicians with a reference for incorporating SGLT2 inhibitors into the treatment of heart failure and other cardiovascular conditions.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":"19 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148204891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Hidden Indicator of Cardiovascular Health: Serum Gamma-Glutamyl Transferase in Focus. 心血管健康的一个隐藏指标：血清γ -谷氨酰转移酶的焦点。
IF 2.6 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2026-06-08 DOI: 10.1007/s12265-026-10788-2
Akanksha Saini, Manik, Zaid Bashir, Dinesh Kumar Mehta, Savita Kumari, Rina Das
{"title":"A Hidden Indicator of Cardiovascular Health: Serum Gamma-Glutamyl Transferase in Focus.","authors":"Akanksha Saini, Manik, Zaid Bashir, Dinesh Kumar Mehta, Savita Kumari, Rina Das","doi":"10.1007/s12265-026-10788-2","DOIUrl":"10.1007/s12265-026-10788-2","url":null,"abstract":"<p><p>Glutathione, a critical component of cellular antioxidant defences, is metabolized by gamma-glutamyl transferase (GGT), an enzyme increasingly recognized for its role in cardiovascular diseases (CVD). Elevated GGT levels have been associated with a heightened risk of conditions such as heart failure, coronary artery disease, acute coronary events, and adverse cardiovascular outcomes. This study aims to evaluate the role of serum GGT as a cardiac marker for detecting various cardiac diseases and its potential utility in clinical practice. Elevated GGT correlates with several CVD risk factors, including diabetes, hypertension, and metabolic syndrome, and is associated with acute coronary syndromes and myocardial infarction. The study results suggest that serum GGT is a promising biomarker for cardiovascular risk prediction, aiding in the assessment of disease severity and prognosis. GGT has the potential to play a pivotal role in preventive cardiology and personalized medicine, contributing to improved outcomes for patients with CVD.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":"19 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148199071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Large Animal Models of Tricuspid Regurgitation: Relevance, Limitations, and Future Directions. 大型三尖瓣反流动物模型：相关性、局限性和未来方向。
IF 2.6 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2026-06-08 DOI: 10.1007/s12265-026-10798-0
Talia Sukienik, Kosuke Nakamae, Chihiro Miyagi, Grisha Yelisetty, Syed Faizullah Hussaini, Tatsuya Watanabe, Junya Matsuda, Satoshi Yuhara, Daisuke Onohara
{"title":"Large Animal Models of Tricuspid Regurgitation: Relevance, Limitations, and Future Directions.","authors":"Talia Sukienik, Kosuke Nakamae, Chihiro Miyagi, Grisha Yelisetty, Syed Faizullah Hussaini, Tatsuya Watanabe, Junya Matsuda, Satoshi Yuhara, Daisuke Onohara","doi":"10.1007/s12265-026-10798-0","DOIUrl":"10.1007/s12265-026-10798-0","url":null,"abstract":"<p><p>Despite growing interest in tricuspid regurgitation (TR), evidence remains insufficient to define the optimal timing of intervention and therapeutic strategies, highlighting the need for robust experimental models. Existing large animal models of TR use diverse approaches and can be grouped into two categories: direct valvular interventions targeting the tricuspid leaflets, annulus, or chordae, and indirect induction through mechanisms such as increased right ventricular loading, pulmonary hypertension, or pacing-induced tachycardia. Although direct valvular interventions can reproducibly induce TR and are well suited for modeling primary TR, clinically prevalent secondary TR is driven by annular dilation, leaflet tethering, and right-sided chamber remodeling rather than intrinsic valvular injury. This gap represents a major limitation in the field. In this review, we compare large animal models of TR and outline key considerations to guide model selection, with a focus on approaches that more faithfully reproduce the pathophysiology of TR for mechanistic and translational research.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":"19 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13246952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148204904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CardiOmicScore: a Multitask AI Model for Cardiovascular Disease Prediction. CardiOmicScore：用于心血管疾病预测的多任务AI模型。
IF 2.6 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2026-06-03 DOI: 10.1007/s12265-026-10796-2
Luzhang Ji, Xinxiu Meng, Shuqin Liu, Junjie Xiao
{"title":"CardiOmicScore: a Multitask AI Model for Cardiovascular Disease Prediction.","authors":"Luzhang Ji, Xinxiu Meng, Shuqin Liu, Junjie Xiao","doi":"10.1007/s12265-026-10796-2","DOIUrl":"10.1007/s12265-026-10796-2","url":null,"abstract":"","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":"19 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148149948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PSAP Protects Against Acute Myocardial Ischemia-Reperfusion Injury by Promoting ASAH1-Mediated Ceramide Metabolism. PSAP通过促进asah1介导的神经酰胺代谢来预防急性心肌缺血再灌注损伤。
IF 2.6 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2026-06-03 DOI: 10.1007/s12265-026-10779-3
Yiqing Chen, Xuan Ye, Chenyang Zha, Chi Jin, Huihua Chen, Hongyun Wang, Junjie Xiao
{"title":"PSAP Protects Against Acute Myocardial Ischemia-Reperfusion Injury by Promoting ASAH1-Mediated Ceramide Metabolism.","authors":"Yiqing Chen, Xuan Ye, Chenyang Zha, Chi Jin, Huihua Chen, Hongyun Wang, Junjie Xiao","doi":"10.1007/s12265-026-10779-3","DOIUrl":"10.1007/s12265-026-10779-3","url":null,"abstract":"<p><p>Myocardial ischemia-reperfusion (I/R) injury remains a leading cause of cardiovascular morbidity. However, due to the unclear underlying molecular mechanisms, effective therapeutic approaches are still lacking. This study aims to investigate the function and downstream mechanism of the lysosomal protein prosaposin (PSAP) in regulating ceramide homeostasis and cardiomyocyte apoptosis during acute I/R injury. In our study, we found that PSAP expression was significantly downregulated in the heart subjected to acute I/R surgery. Restoration of PSAP protein via AAV9-PSAP-OE in vivo significantly reduced infarct size and attenuated cardiomyocyte apoptosis. Similarly, PSAP overexpression in OGD/R-treated primary cardiomyocytes (NRCMs) decreased apoptosis, while PSAP knockdown exacerbated apoptosis. Mechanistically, PSAP accelerates the ceramide degradation pathway by rescuing the expression of the lysosomal N-acylsphingosine amidohydrolase 1 (ASAH1), thereby attenuating I/R-induced ceramide accumulation and cardiomyocyte apoptosis. Our results reveal a novel mechanism of PSAP function and highlight its potential as a therapeutic target for acute myocardial I/R injury.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":"19 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148149879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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