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Journal of Cardiovascular Translational Research最新文献

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Diagnostic Value and Short-Term Prognosis Assessment of Copeptin in Non-ST-Elevation Acute Coronary Syndrome. Copeptin在非st段抬高急性冠脉综合征中的诊断价值及短期预后评价。
IF 2.4 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2025-04-01 Epub Date: 2024-12-28 DOI: 10.1007/s12265-024-10584-w
Facai Cui, Xueliang Pei, Mingzhi Ling, Fengxia Guo
{"title":"Diagnostic Value and Short-Term Prognosis Assessment of Copeptin in Non-ST-Elevation Acute Coronary Syndrome.","authors":"Facai Cui, Xueliang Pei, Mingzhi Ling, Fengxia Guo","doi":"10.1007/s12265-024-10584-w","DOIUrl":"10.1007/s12265-024-10584-w","url":null,"abstract":"<p><p>This study explored the early diagnosis and prognostic value of copeptin in non-ST-segment elevation acute coronary syndrome (NSTE-ACS). 171 patients with chest pain or myocardial ischemia symptoms were enrolled. Patients with NSTE-ACS were further divided into the non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA). All NSTE-ACS patients were followed up to record the occurrence of Major Adverse Cardiovascular Events (MACEs). Serum copeptin concentration in the NSTE-ACS group was significantly higher than that in the control group. The Area under the curve (AUC) value of copeptin in the diagnosis of NSTE-ACS was 0.798. The combined AUC value of copeptin and hypersensitive troponin I (hs-TnI) to NSTE-ACS increased to 0.930. In addition, copeptin and hs-TnI have been proven to be independent risk factors for MACEs in patients with NSTE-ACS. The use of copeptin in combination with conventional myocardial markers contributes to the early diagnosis and short-term prognosis assessment of NSTE-ACS.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"366-374"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanical and Geometric Characterization of a Novel 2-Ply Vacuum-Pressed Biological Scaffold Patch Design for Posterior Mitral Valve Reconstruction. 用于二尖瓣后瓣重建的新型双层真空压制生物支架补片设计的机械和几何特性。
IF 2.4 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2025-04-01 Epub Date: 2024-10-28 DOI: 10.1007/s12265-024-10572-0
Johannes H Jedrzejczyk, Frederik T Andersen, Jacob Petersen, Alexander Emil Kaspersen, Urjosee Sahana, Søren N Skov, Jens T Væsel, J Michael Hasenkam, Marcell J Tjørnild
{"title":"Mechanical and Geometric Characterization of a Novel 2-Ply Vacuum-Pressed Biological Scaffold Patch Design for Posterior Mitral Valve Reconstruction.","authors":"Johannes H Jedrzejczyk, Frederik T Andersen, Jacob Petersen, Alexander Emil Kaspersen, Urjosee Sahana, Søren N Skov, Jens T Væsel, J Michael Hasenkam, Marcell J Tjørnild","doi":"10.1007/s12265-024-10572-0","DOIUrl":"10.1007/s12265-024-10572-0","url":null,"abstract":"<p><p>To assess the mechanical properties of small intestinal submucosal extracellular matrix (SIS-ECM) iterations and choose the optimal version for evaluating functional geometrics after posterior mitral valve reconstruction. Four SIS-ECM versions (2- and 4-ply vacuum-pressed and lyophilized) underwent uniaxial tensile testing. A posterior mitral valve reconstruction patch was developed based on MRI scans (n = 5). Posterior mitral valve reconstruction using 2-ply vacuum-pressed SIS-ECM was performed (n = 7), and geometrics were evaluated using a modified left heart simulator. The vacuum-pressed iterations displayed superior maximum stress values compared to lyophilized (2-ply: median [IQR], 15.8 [15.2-19.0] vs 7.9 [7.3-8.3] MPa, p < 0.001; 4-ply: median (IQR), 15.8 -[14.6-22.0] vs 7.9 [7.6-8.4] MPa). All reconstructed valves were competent with preserved total leaflet area, but individual leaflet segment areas were redistributed. Posterior mitral valve reconstruction with our 2-ply vacuum-pressed SIS-ECM patch design was feasible in vitro. Further in vivo evaluation is warranted.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"268-279"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
p16INK4a Aggravated Sepsis-associated Cardiac Injury by Inhibiting the PI3K/AKT Pathway and Inducing Redox Imbalance. p16INK4a通过抑制PI3K/AKT通路和诱导氧化还原失衡加重败血症相关的心脏损伤。
IF 2.4 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2025-04-01 Epub Date: 2025-01-14 DOI: 10.1007/s12265-024-10588-6
Baihong Li, Kai Wang, Xiaoyan Wang, Zhixuan Zhang, Guangyi Huang, Yiyi Ma, Yingqiang Du, Xin Gu, Jie Hui
{"title":"p16<sup>INK4a</sup> Aggravated Sepsis-associated Cardiac Injury by Inhibiting the PI3K/AKT Pathway and Inducing Redox Imbalance.","authors":"Baihong Li, Kai Wang, Xiaoyan Wang, Zhixuan Zhang, Guangyi Huang, Yiyi Ma, Yingqiang Du, Xin Gu, Jie Hui","doi":"10.1007/s12265-024-10588-6","DOIUrl":"10.1007/s12265-024-10588-6","url":null,"abstract":"<p><p>Severe sepsis can promote myocardial injury and cardiac dysfunction, but role of p16 in sepsis-induced myocardial injury remains undefined. PBMCs were collected from patients. Expression of inflammatory factors and NLRP3 pathway were detected by Western blotting and qPCR in WT and p16KO mice. Then detect cardiomyocyte apoptosis and ROS levels in vitro. Detailed pathways and mechanisms were revealed through quantitative proteomic analysis combined with GSEA and KEGG analysis. p16 was overexpressed in PBMCs of patient. p16 knockout alleviated cardiac dysfunction in LPS-induced mice and inhibited NLRP3 inflammasome pathway in vivo and in vitro. Quantitative proteomic analysis revealed that p16 knockout contributed to the activation of the PI3K/Akt pathway in LPS-induced cardiac injury. p16 knockout promoted activation of the PI3K/Akt pathway and ameliorated NLRP3 pathway inhibition and redox imbalance thus improving cardiac function in LPS-induced cardiomyopathy mice.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"375-391"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Machine Learning Model for Risk Prediction of Prolonged Intensive Care Unit in Patients Receiving Intra-aortic Balloon Pump Therapy during Coronary Artery Bypass Graft Surgery. 机器学习模型在冠状动脉搭桥术中接受主动脉内球囊泵治疗的患者延长重症监护病房的风险预测。
IF 2.4 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2025-04-01 Epub Date: 2024-12-24 DOI: 10.1007/s12265-024-10580-0
Changqing Yang, Peng Zheng, Qian Zhang, Luo Li, Yajun Zhang, Quanye Li, Sheng Zhao, Zhan Shi
{"title":"Machine Learning Model for Risk Prediction of Prolonged Intensive Care Unit in Patients Receiving Intra-aortic Balloon Pump Therapy during Coronary Artery Bypass Graft Surgery.","authors":"Changqing Yang, Peng Zheng, Qian Zhang, Luo Li, Yajun Zhang, Quanye Li, Sheng Zhao, Zhan Shi","doi":"10.1007/s12265-024-10580-0","DOIUrl":"10.1007/s12265-024-10580-0","url":null,"abstract":"<p><p>This study aimed to construct machine learning models and predict prolonged intensive care units (ICU) stay in patients receiving perioperative intra-aortic balloon pump (IABP) therapy during cardiac surgery. 236 patients were divided into the normal (≤ 14 days) and prolonged (> 14 days) ICU groups based on the 75th percentile of ICU duration across the entire cohort. Seven machine learning models were trained and validated. The Shapley Additive explanations (SHAP) method was employed to illustrate the effects of the features. 94 patients (39.83%) experienced prolonged ICU stay. The XGBoost model outperformed other models in predictive performance, as evidenced by its highest area under the receiver operating characteristic curve (training: 0.92; validation: 0.73). The SHAP analysis identified tracheotomy, albumin, Sv1, and cardiac troponin T as the top four risk variables. The XGBoost model predicted risk variables for prolonged ICU stay in patients, possibly contributing to improving perioperative management and reducing ICU duration.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"341-353"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and Internal Validation of an AI-Enabled Cuff-less, Non-invasive Continuous Blood Pressure Monitor Across All Classes of Hypertension. 开发并在内部验证人工智能无袖带无创连续血压监测仪，适用于所有类型的高血压。
IF 2.4 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2025-04-01 Epub Date: 2025-01-13 DOI: 10.1007/s12265-024-10589-5
Francisco Lopez-Jimenez, Abhishek Deshmukh, John Bisognano, John Boehmer, Mouli Ramasamy, Prashanth Shyam Kumar, Suraj Kapa, Venk Varadan, Vijay Varadan, Marat Fudim
{"title":"Development and Internal Validation of an AI-Enabled Cuff-less, Non-invasive Continuous Blood Pressure Monitor Across All Classes of Hypertension.","authors":"Francisco Lopez-Jimenez, Abhishek Deshmukh, John Bisognano, John Boehmer, Mouli Ramasamy, Prashanth Shyam Kumar, Suraj Kapa, Venk Varadan, Vijay Varadan, Marat Fudim","doi":"10.1007/s12265-024-10589-5","DOIUrl":"10.1007/s12265-024-10589-5","url":null,"abstract":"<p><strong>Background: </strong>Non-invasive, continuous blood pressure monitoring technologies require additional validation beyond standard cuff-based methods. This study evaluates a non-invasive, multiparametric wearable cuffless blood pressure (BP) diagnostic monitor across all hypertension classes with diverse subjects.</p><p><strong>Methods: </strong>A prospective, multicenter study assessed Nanowear's SimpleSense-BP performance, including induced and natural BP changes, significant BP variations (Systolic BP (SBP) ≥ ± 15 mm Hg and Diastolic BP (DBP) ≥ ± 10 mm Hg), and reference input value validity over 4 weeks.</p><p><strong>Results: </strong>303 subjects (18-83 yrs; 50.16% Female) participated in algorithmic development and validation (Normal - 35%, Prehypertensive - 24%, Stage 1 - 24%, Stage 2 - 17%). 54 subjects were tested for induced change performance, 149 exhibited significant changes, and 91 validated reference value duration.</p><p><strong>Conclusions: </strong>The study clinically validated a continuous, AI-based BP diagnostic monitor using non-invasive wearable data. Further testing on diverse populations and external validation are recommended. The protocol was inspired by ISO 81060-2 and IEEE 1708:2019 standards.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"280-290"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mesenchymal Stem Cell-based Apelin Gene Therapy Improves Pulmonary Artery Remodeling in Monocrotaline-induced Pulmonary Hypertension Through PI3K/AKT/eNOS and ERK1/2 Signaling Pathways. 基于间充质干细胞的Apelin基因治疗通过PI3K/AKT/eNOS和ERK1/2信号通路改善单芥碱诱导的肺动脉高压的肺动脉重塑
IF 2.4 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2025-04-01 DOI: 10.1007/s12265-025-10612-3
Li Wang, Weijian Wang, Ting Wu, Liang Chen, Gangjun Zong
{"title":"Mesenchymal Stem Cell-based Apelin Gene Therapy Improves Pulmonary Artery Remodeling in Monocrotaline-induced Pulmonary Hypertension Through PI3K/AKT/eNOS and ERK1/2 Signaling Pathways.","authors":"Li Wang, Weijian Wang, Ting Wu, Liang Chen, Gangjun Zong","doi":"10.1007/s12265-025-10612-3","DOIUrl":"https://doi.org/10.1007/s12265-025-10612-3","url":null,"abstract":"<p><p>Pulmonary arterial hypertension (PAH) poses a challenge due to limited curative options and ineffective treatments. Mesenchymal stem cell (MSC) therapy has emerged as a potential intervention for PAH. This study delved into the therapeutic potential and molecular mechanisms underlying MSC-based apelin gene therapy in PAH rats induced by monocrotaline (MCT). Wharton's jelly-derived MSCs transfected with pcSLenti-APLN were utilized as therapeutic agents. Transplanted MSCs successfully homed to the lung tissue of rats and sustained survival for at least three weeks. MSC-mediated apelin gene therapy effectively reduced pulmonary artery pressure, mitigated pulmonary vascular remodeling, and modulated apoptosis in MCT-induced PAH rats. Furthermore, the phosphatidylinositol 3-kinase (PI3K)/AKT/endothelial nitric oxide synthase (eNOS) and ERK1/2 signaling pathways were involved in the therapeutic effects. Meanwhile, Apelin-MSCs also regulated MCT-induced changes of Bax and Bcl-2 in the lung lobes and pulmonary arterioles. MSC-based apelin gene therapy could be considered a possible therapeutic strategy for PAH.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lymphatic Drainage in Patients with Heart Failure: A Feasibility Study. 心力衰竭患者淋巴引流的可行性研究。
IF 2.4 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2025-04-01 Epub Date: 2025-02-03 DOI: 10.1007/s12265-025-10592-4
Husam M Salah, Adrian Ebner, Ravi N Srinivasa, Waleska Pabon-Ramos, Jeffrey Forris Beecham Chick, Jan Biegus, Piotr Ponikowski, Abubaker Khalifa, Marat Fudim
{"title":"Lymphatic Drainage in Patients with Heart Failure: A Feasibility Study.","authors":"Husam M Salah, Adrian Ebner, Ravi N Srinivasa, Waleska Pabon-Ramos, Jeffrey Forris Beecham Chick, Jan Biegus, Piotr Ponikowski, Abubaker Khalifa, Marat Fudim","doi":"10.1007/s12265-025-10592-4","DOIUrl":"10.1007/s12265-025-10592-4","url":null,"abstract":"<p><p>Lymphatic dysfunction contributes to congestion and end-organ damage in heart failure (HF), yet current therapies do not directly target lymphatic congestion. Thoracic duct (TD) drainage offers a novel approach to address this gap. This multicenter feasibility study evaluated the safety and feasibility of minimally invasive TD drainage in patients with HF. Four patients with New York Heart Association class II-IV HF and fluid overload underwent fluoroscopy-guided TD access via cervical, abdominal, or transvenous brachial approaches. Lymph was drained by gravity for up to 3 hours, and hemodynamic changes were measured. TD drainage was successful in all patients, with a mean lymph output of 430 mL. Mean reductions in right atrial and pulmonary capillary wedge pressures were 4 mmHg and 1.5 mmHg, respectively. No major adverse events occurred. TD drainage appears feasible and safe, with potential decongestive benefits. Larger studies are needed to confirm its role in HF management.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"291-294"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NAT10 Modulates Atherosclerosis Progression Mediated by Macrophage Polarization Through Regulating ac4C Modification of TLR9. NAT10通过调节TLR9的ac4C修饰调节巨噬细胞极化介导的动脉粥样硬化进程。
IF 2.4 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2025-04-01 Epub Date: 2024-12-19 DOI: 10.1007/s12265-024-10579-7
Wei Yin, Jie Wang, Lingling Li, Hongyun Zheng, Shengkai Xu
{"title":"NAT10 Modulates Atherosclerosis Progression Mediated by Macrophage Polarization Through Regulating ac4C Modification of TLR9.","authors":"Wei Yin, Jie Wang, Lingling Li, Hongyun Zheng, Shengkai Xu","doi":"10.1007/s12265-024-10579-7","DOIUrl":"10.1007/s12265-024-10579-7","url":null,"abstract":"<p><p>Atherosclerosis (AS) is an inflammatory disease affected by macrophage polarization. N<sup>4</sup>-acetylcytosine (ac4C) modification mediated by N-acetyltransferase 10 (NAT10). In this study, we aimed to elucidate the role of ac4C modification mediated macrophage polarization in AS through in vivo and in vitro experiments. The ac4C level was measured using dot blot. Macrophage polarization was assessed by quantitative real-time PCR and flow cytometry. Underlying mechanism was analyzed by methylated RNA Immunoprecipitation (MeRIP), RIP and dual luciferase report. Results showed that the NAT10 expression and ac4C level were increased in patients with AS. Additionally, NAT10 knockdown promoted M1 to M2 polarization and suppressed TLR9 ac4C level. TLR9 overexpression reversed macrophage polarization regulated by NAT10 knockdown. Furthermore, M1 polarization and atherosclerosis in vivo was inhibited by NAT10 knockdown. In conclusion, we demonstrated that NAT10 regualted AS progression mediated by macrophage polarization through regulating ac4C modification of TLR9 and provided a new theoretical basis.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"247-256"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Class III Phosphatidylinositol-3 Kinase/Vacuolar Protein Sorting 34 in Cardiovascular Health and Disease. ⅲ类磷脂酰肌醇-3激酶/液泡蛋白分选34在心血管健康和疾病中的作用。
IF 2.4 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2025-04-01 Epub Date: 2025-01-16 DOI: 10.1007/s12265-024-10581-z
Yuanjun Shen, Jason P Gleghorn
{"title":"Class III Phosphatidylinositol-3 Kinase/Vacuolar Protein Sorting 34 in Cardiovascular Health and Disease.","authors":"Yuanjun Shen, Jason P Gleghorn","doi":"10.1007/s12265-024-10581-z","DOIUrl":"10.1007/s12265-024-10581-z","url":null,"abstract":"<p><p>Phosphatidylinositol-3 kinases (PI3Ks) play a critical role in maintaining cardiovascular health and the development of cardiovascular diseases (CVDs). Specifically, vacuolar Protein Sorting 34 (VPS34) or PIK3C3, the only member of Class III PI3K, plays an important role in CVD progression. The main function of VPS34 is inducing the production of phosphatidylinositol 3-phosphate, which, together with other essential structural and regulatory proteins in forming VPS34 complexes, further regulates the mammalian target of rapamycin activation, autophagy, and endocytosis. VPS34 is found to have crucial functions in the cardiovascular system, including dictating the proliferation and survival of vascular smooth muscle cells and cardiomyocytes and the formation of thrombosis. This review aims to summarize our current knowledge and recent advances in understanding the function and regulation of VPS34 in cardiovascular health and disease. We also discuss the current development of VPS34 inhibitors and their potential to treat CVDs.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"392-407"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial Dysfunction in HFpEF: Potential Interventions Through Exercise. 高频心衰的线粒体功能障碍：通过运动进行潜在干预
IF 2.4 3区 医学
Journal of Cardiovascular Translational Research Pub Date : 2025-04-01 Epub Date: 2025-01-25 DOI: 10.1007/s12265-025-10591-5
Xinxin Cui, Michail Spanos, Cuimei Zhao, Wensi Wan, Caiyue Cui, Lijun Wang, Junjie Xiao
{"title":"Mitochondrial Dysfunction in HFpEF: Potential Interventions Through Exercise.","authors":"Xinxin Cui, Michail Spanos, Cuimei Zhao, Wensi Wan, Caiyue Cui, Lijun Wang, Junjie Xiao","doi":"10.1007/s12265-025-10591-5","DOIUrl":"10.1007/s12265-025-10591-5","url":null,"abstract":"<p><p>HFpEF is a prevalent and complex type of heart failure. The concurrent presence of conditions such as obesity, hypertension, hyperglycemia, and hyperlipidemia significantly increase the risk of developing HFpEF. Mitochondria, often referred to as the powerhouses of the cell, are crucial in maintaining cellular functions, including ATP production, intracellular Ca<sup>2+</sup> regulation, reactive oxygen species generation and clearance, and the regulation of apoptosis. Exercise plays a vital role in preserving mitochondrial homeostasis, thereby protecting the cardiovascular system from acute stress, and is a fundamental component in maintaining cardiovascular health. In this study, we review the mitochondrial dysfunction underlying the development and progression of HFpEF. Given the pivotal role of exercise in modulating cardiovascular diseases, we particularly focus on exercise as a potential therapeutic strategy for improving mitochondrial function. Graphical abstract Note: This picture was created with BioRender.com.</p>","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"442-456"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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