Journal of Cardiovascular Translational Research最新文献_第6页

An Updated Comprehensive Review of Existing Transcatheter Aortic Valve Replacement Access. 对现有经导管主动脉瓣置换术通路的最新全面回顾。

IF 4.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-10-01 Epub Date: 2024-08-26 DOI: 10.1007/s12265-024-10484-z

Wenjing Sheng, Hanyi Dai, Rongrong Zheng, Ailifeire Aihemaiti, Xianbao Liu

引用次数: 0

The activation of P38MAPK Signaling Pathway Impedes the Delivery of the Cx43 to the Intercalated Discs During Cardiac Ischemia-Reperfusion Injury. 在心脏缺血再灌注损伤过程中，P38MAPK 信号通路的激活阻碍了 Cx43 向椎间盘的输送。

IF 4.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-10-01 Epub Date: 2024-05-02 DOI: 10.1007/s12265-024-10515-9

Xiang Huang, Xue Bai, Jing Yi, Tingju Hu, Li An, Hong Gao

{"title":"The activation of P38MAPK Signaling Pathway Impedes the Delivery of the Cx43 to the Intercalated Discs During Cardiac Ischemia-Reperfusion Injury.","authors":"Xiang Huang, Xue Bai, Jing Yi, Tingju Hu, Li An, Hong Gao","doi":"10.1007/s12265-024-10515-9","DOIUrl":"10.1007/s12265-024-10515-9","url":null,"abstract":"Ischemic heart disease is caused by coronary artery occlusion. Despite the increasing number and success of interventions for restoring coronary artery perfusion, myocardial ischemia-reperfusion (I/R) injury remains a significant cause of morbidity and mortality worldwide. Inspired by the impact of I/R on the Cx43 trafficking to the intercalated discs (ICDs), we aim to explore the potential mechanisms underlying the downregulation of Cx43 in ICDs after myocardial I/R. Gene set enrichment analysis (GSEA), Western blotting, and immunofluorescence experiments showed that Myocardial I/R activated the P38MAPK signaling pathway and promoted microtubule depolymerization. Inhibition of P38MAPK signaling pathway activation attenuated I/R-induced microtubule depolymerization. The ability of SB203580 to recover the distribution of Cx43 and electrophysiological parameters in I/R myocardium depended on microtubule stability. Our study suggests that microtubule depolymerization caused by the activation of the P38MAPK signaling pathway is an important mechanism underlying the downregulation of Cx43 in ICDs after myocardial I/R.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"1140-1154"},"PeriodicalIF":4.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140855101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Genetic Factors Influencing Cardiomyopathies and Heart Failure across the Allele Frequency Spectrum. 影响心肌病和心力衰竭的各种等位基因频率的遗传因素。

IF 4.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-10-01 Epub Date: 2024-05-21 DOI: 10.1007/s12265-024-10520-y

Srinjay Mukhopadhyay, Prithvi Dixit, Najiyah Khanom, Gianluca Sanghera, Kathryn A McGurk

引用次数: 0

Exosome is a Fancy Mobile Sower of Ferroptosis. 外泌体是铁突变的花式移动播种机。

IF 4.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-10-01 Epub Date: 2024-05-22 DOI: 10.1007/s12265-024-10508-8

Qin Hou, Siyu Ouyang, Zhongcheng Xie, Yinling He, Yunong Deng, Jiamin Guo, Panpan Yu, Xiaoqian Tan, Wentao Ma, Pin Li, Jiang Yu, Qinger Mo, Zhixia Zhang, Dandan Chen, Xiaoyan Lin, Zhiyang Liu, Xi Chen, Tianhong Peng, Liang Li, Wei Xie

{"title":"Exosome is a Fancy Mobile Sower of Ferroptosis.","authors":"Qin Hou, Siyu Ouyang, Zhongcheng Xie, Yinling He, Yunong Deng, Jiamin Guo, Panpan Yu, Xiaoqian Tan, Wentao Ma, Pin Li, Jiang Yu, Qinger Mo, Zhixia Zhang, Dandan Chen, Xiaoyan Lin, Zhiyang Liu, Xi Chen, Tianhong Peng, Liang Li, Wei Xie","doi":"10.1007/s12265-024-10508-8","DOIUrl":"10.1007/s12265-024-10508-8","url":null,"abstract":"Exosomes, nano-sized small extracellular vesicles, have been shown to serve as mediators between intercellular communications by transferring bioactive molecules, such as non-coding RNA, proteins, and lipids from secretory to recipient cells, modulating a variety of physiological and pathophysiological processes. Recent studies have gradually demonstrated that altered exosome charges may represent a key mechanism driving the pathological process of ferroptosis. This review summarizes the potential mechanisms and signal pathways relevant to ferroptosis and then discusses the roles of exosome in ferroptosis. As well as transporting iron, exosomes may also indirectly convey factors related to ferroptosis. Furthermore, ferroptosis may be transmitted to adjacent cells through exosomes, resulting in cascading effects. It is expected that further research on exosomes will be conducted to explore their potential in ferroptosis and will lead to the creation of new therapeutic avenues for clinical diseases.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"1067-1082"},"PeriodicalIF":4.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141076036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondria-Associated Organelle Crosstalk in Myocardial Ischemia/Reperfusion Injury. 心肌缺血/再灌注损伤中线粒体与相关细胞器的相互影响

IF 4.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-10-01 Epub Date: 2024-05-28 DOI: 10.1007/s12265-024-10523-9

Hui Yao, Yuxin Xie, Chaoquan Li, Wanting Liu, Guanghui Yi

{"title":"Mitochondria-Associated Organelle Crosstalk in Myocardial Ischemia/Reperfusion Injury.","authors":"Hui Yao, Yuxin Xie, Chaoquan Li, Wanting Liu, Guanghui Yi","doi":"10.1007/s12265-024-10523-9","DOIUrl":"10.1007/s12265-024-10523-9","url":null,"abstract":"Organelle damage is a significant contributor to myocardial ischemia/reperfusion (I/R) injury. This damage often leads to disruption of endoplasmic reticulum protein regulatory programs and dysfunction of mitochondrial energy metabolism. Mitochondria and endoplasmic reticulum are seamlessly connected through the mitochondrial-associated endoplasmic reticulum membrane (MAM), which serves as a crucial site for the exchange of organelles and metabolites. However, there is a lack of reports regarding the communication of information and metabolites between mitochondria and related organelles, which is a crucial factor in triggering myocardial I/R damage. To address this research gap, this review described the role of crosstalk between mitochondria and the correlative organelles such as endoplasmic reticulum, lysosomal and nuclei involved in reperfusion injury of the heart. In summary, this review aims to provide a comprehensive understanding of the crosstalk between organelles in myocardial I/R injury, with the ultimate goal of facilitating the development of targeted therapies based on this knowledge.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"1106-1118"},"PeriodicalIF":4.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141160175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential Effects of Pharmacologic and Mechanical Support on Right-Left Ventricular Coupling. 药物和机械支持对左右心室耦合的不同影响

IF 4.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-10-01 Epub Date: 2024-05-20 DOI: 10.1007/s12265-024-10522-w

Kimberly K Lamberti, Efrat M Goffer, Elazer R Edelman, Steven P Keller

{"title":"Differential Effects of Pharmacologic and Mechanical Support on Right-Left Ventricular Coupling.","authors":"Kimberly K Lamberti, Efrat M Goffer, Elazer R Edelman, Steven P Keller","doi":"10.1007/s12265-024-10522-w","DOIUrl":"10.1007/s12265-024-10522-w","url":null,"abstract":"Background: Percutaneous ventricular assist devices are increasingly relied on to maintain perfusion for cardiogenic shock patients. Optimal medical management strategies however remain uncertain from limited understanding of interventricular effects. This study analyzed the effects of pharmacologic and left-sided mechanical support on right ventricular function.Methods: A porcine model was developed to assess biventricular function during bolus pharmacologic administration before and after left-sided percutaneous ventricular assist and in cardiogenic shock.Results: The presence of mechanical support increased right ventricular load and stress with respect to the left ventricle. This shifted and exaggerated the relative effects of commonly used vasoactive agents. Furthermore, induction of cardiogenic shock led to differential pulmonary vascular and right ventricular responses.Conclusions: Left ventricular ischemia and mechanical support altered interventricular coupling. Resulting impacts of pharmacologic agents indicate differential right heart responses and sensitivity to treatments and the need for further study to optimize biventricular function in shock patients.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":"1181-1192"},"PeriodicalIF":4.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11518637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective Mechanisms of SGLTi in Ischemic Heart Disease. SGLTi 对缺血性心脏病的保护机制

IF 4.6 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-10-01 Epub Date: 2024-05-20 DOI: 10.1007/s12265-024-10513-x

Lei Liao, Tong Wang, Lu Zhang, Yan Wei, Xinrong Fan

引用次数: 0

CNDP2: An Enzyme Linking Metabolism and Cardiovascular Diseases? CNDP2：连接新陈代谢和心血管疾病的酶？

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-09-30 DOI: 10.1007/s12265-024-10560-4

Moizle Grace Castro Ocariza, Louise Nancy Paton, Evelyn Mary Templeton, Christopher Joseph Pemberton, Anna Pauline Pilbrow, Sarah Appleby

{"title":"CNDP2: An Enzyme Linking Metabolism and Cardiovascular Diseases?","authors":"Moizle Grace Castro Ocariza, Louise Nancy Paton, Evelyn Mary Templeton, Christopher Joseph Pemberton, Anna Pauline Pilbrow, Sarah Appleby","doi":"10.1007/s12265-024-10560-4","DOIUrl":"https://doi.org/10.1007/s12265-024-10560-4","url":null,"abstract":"The heart requires a substantial amount of energy to function, utilising various substrates including lipids, glucose and lactate as energy sources. In times of increased stress, lactate becomes the primary energy source of the heart, but persistently elevated lactate levels are linked to poor patient outcomes and increased mortality. Recently, carnosine dipeptidase II (CNDP2) was discovered to catalyse the formation of Lac-Phe, an exercise-induced metabolite derived from lactate, which has been shown to suppress appetite in mice and reduce adipose tissue in humans. This review discusses CNDP2, including its role in lactate clearance, carnosine hydrolysis, oxidative stress regulation, and involvement in metabolite regulation. The association between CNDP2 and cardiometabolic and renal diseases is also explored, and knowledge gaps are highlighted. CNDP2 appears to be a complex participant in human physiological processes and disease, necessitating additional research to unveil its functions and potential therapeutic applications.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142347439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemodynamic Analysis in Aortic Dilatation after Arterial Switch Operation for Patients with Transposition of Great Arteries Using Computational Fluid Dynamics. 利用计算流体力学分析大动脉错位患者动脉转换手术后主动脉扩张的血流动力学。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-09-25 DOI: 10.1007/s12265-024-10562-2

Woo Young Park, Sang Yun Lee, Jongmin Seo

{"title":"Hemodynamic Analysis in Aortic Dilatation after Arterial Switch Operation for Patients with Transposition of Great Arteries Using Computational Fluid Dynamics.","authors":"Woo Young Park, Sang Yun Lee, Jongmin Seo","doi":"10.1007/s12265-024-10562-2","DOIUrl":"https://doi.org/10.1007/s12265-024-10562-2","url":null,"abstract":"After an arterial switch operation for complete transposition of the great arteries, neo-aortic root dilatation occurs, with unclear hemodynamic effects. This study analyzes three groups (severe dilation, mild dilation, and normal) using computational fluid dynamics (CFD) on cardiac CT scans. Aortic arch angles in severe (median 72.3, range: 68.5-77.2) and mild dilation (76.6, 71.1-85.2) groups are significantly smaller than the normal group (97.3, 87.4-99.0). In the normal and mild dilatation groups, Wall Shear Stress (WSS) exhibits a consistent pattern: it is lowest at the aortic root, gradually increases until just before the bend in the aortic arch, peaks, and then subsequently decreases. However, severe dilation shows disrupted WSS patterns, notably lower in the distal ascending aorta, attributed to local recirculation. This unique WSS pattern observed in severely dilated patients, especially in the transverse aorta. CFD plays an essential role in comprehensively studying the pathophysiology underlying aortic dilation in this population.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142347440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leukocyte Extracellular Vesicles Predict Progression of Systolic Dysfunction in Heart Failure with Mildly Reduced Ejection Fraction (LYCHEE) - A Prospective, Multicentre Cohort Study. 白细胞胞外小泡预测射血分数轻度降低的心力衰竭患者收缩功能障碍的进展（LYCHEE）--一项前瞻性多中心队列研究。

IF 2.4 3区医学

Journal of Cardiovascular Translational Research Pub Date : 2024-09-24 DOI: 10.1007/s12265-024-10561-3

Aleksandra Gąsecka, Aleksander Siniarski, Piotr Duchnowski, Konrad Stępień, Ewelina Błażejowska, Magdalena Gajewska, Kacper Karaban, Kinga Porębska, Aleksandra Reda, Sylwester Rogula, Bartosz Rolek, Dorota Słupik, Roksana Gozdowska, Marcin Kleibert, Dominika Zajkowska, Michał Grąt, Marcin Grabowski, Krzysztof J Filipiak, Edwin van der Pol, Rienk Nieuwland

{"title":"Leukocyte Extracellular Vesicles Predict Progression of Systolic Dysfunction in Heart Failure with Mildly Reduced Ejection Fraction (LYCHEE) - A Prospective, Multicentre Cohort Study.","authors":"Aleksandra Gąsecka, Aleksander Siniarski, Piotr Duchnowski, Konrad Stępień, Ewelina Błażejowska, Magdalena Gajewska, Kacper Karaban, Kinga Porębska, Aleksandra Reda, Sylwester Rogula, Bartosz Rolek, Dorota Słupik, Roksana Gozdowska, Marcin Kleibert, Dominika Zajkowska, Michał Grąt, Marcin Grabowski, Krzysztof J Filipiak, Edwin van der Pol, Rienk Nieuwland","doi":"10.1007/s12265-024-10561-3","DOIUrl":"https://doi.org/10.1007/s12265-024-10561-3","url":null,"abstract":"Risk stratification in heart failure with mildly-reduced ejection fraction (HFmrEF) remains challenging. We evaluated the predictive value of advanced glycation end products (AGEs) and plasma concentrations of extracellular vesicles (EVs) for the systolic and diastolic dysfunction progression in HFmrEF patients. Skin AGE accumulation was measured using AGE Reader. Plasma EV concentrations were measured using flow cytometry. Among 74 patients enrolled, 13 (18%) had systolic dysfunction progression and 5 (7%) had diastolic dysfunction progression during 6.5 months follow-up. Leukocyte EVs concentrations were higher in patients with systolic dysfunction progression (p = 0.002) and predicted the progression with 75.0% sensitivity and 58.3% specificity, independent of other clinical variables (OR 4.72, 95% CI 0.99-22.31). Skin AGE levels and concentrations of other EV subtypes were not associated with systolic or diastolic dysfunction progression. Increased leukocyte EVs concentrations are associated with 4.7-fold higher odds of systolic dysfunction progression in HFmrEF patients.","PeriodicalId":15224,"journal":{"name":"Journal of Cardiovascular Translational Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0