脂氧合酶在心血管疾病中的作用

IF 2.4 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiovascular Translational Research Pub Date : 2025-03-25 DOI:10.1007/s12265-025-10605-2

Ting Liu, Ding Ai

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引用次数: 0

摘要

脂氧合酶（Lipoxygenases, LOXs）是一类双加氧酶，可催化亚油酸和花生四烯酸等多不饱和脂肪酸的过氧化，启动生物活性脂质介质的合成。在各种细胞类型中，lox介导的这些生物活性分子的产生在心血管疾病的病理生理中起着至关重要的作用，包括动脉粥样硬化、高血压和心肌缺血再灌注损伤。本文就LOXs及其产物在不同心血管细胞和疾病中的作用进行综述，以期为开发新的心血管疾病治疗策略提供有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Roles of Lipoxygenases in Cardiovascular Diseases.

Lipoxygenases (LOXs) are a family of dioxygenases that catalyze the peroxidation of polyunsaturated fatty acids, such as linoleic acid and arachidonic acid, initiating the synthesis of bioactive lipid mediators. The LOX-mediated production of these bioactive molecules in various cell types plays a critical role in the pathophysiology of cardiovascular diseases, including atherosclerosis, hypertension, and myocardial ischemia-reperfusion injury. In this review, we summarize the roles of LOXs and their products in different cardiovascular cells and conditions, offering valuable insights may contribute to the development of novel therapeutic strategies for cardiovascular diseases.

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来源期刊

Journal of Cardiovascular Translational Research CARDIAC & CARDIOVASCULAR SYSTEMS-MEDICINE, RESEARCH & EXPERIMENTAL

CiteScore

6.10

自引率

2.90%

发文量

148

审稿时长

6-12 weeks

期刊介绍： Journal of Cardiovascular Translational Research (JCTR) is a premier journal in cardiovascular translational research. JCTR is the journal of choice for authors seeking the broadest audience for emerging technologies, therapies and diagnostics, pre-clinical research, and first-in-man clinical trials. JCTR''s intent is to provide a forum for critical evaluation of the novel cardiovascular science, to showcase important and clinically relevant aspects of the new research, as well as to discuss the impediments that may need to be overcome during the translation to patient care.