Sensitivity of Left Atrial Flow Dynamics to Echocardiographic and Computed Tomography Data.

IF 2.4 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiovascular Translational Research Pub Date : 2025-02-19 DOI:10.1007/s12265-025-10598-y

Ahmad Bshennaty, Brennan J Vogl, Ghasaq Saleh, Agata Sularz, Mohamad Alkhouli, Hoda Hatoum

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引用次数: 0

Abstract

Computational simulations are a powerful tool in the understanding, diagnosing, and treatment of cardiovascular diseases. Incomplete clinical data often limits computational assessment, which may lead to inaccuracies. This study aims to assess the sensitivity of left atrial flow dynamics to echocardiographic and computed tomography data. Models of the LA were reconstructed at the E-wave(Geometry 1)and end-diastolic(Geometry 2)phases from CT scans. CFD simulations were carried out using 3 different sets of BCs. BC2 and BC3 presented similar results that were significantly different from BC1. The effect from the choice of geometry was significant with BC2 and BC3 but minor with BC1. Differences in parameters across the simulated cases highlight the importance of using consistent BCs and geometries for CFD studies. Acquiring the pressure in the LA does not seem to be necessary for the accuracy of CFD simulations. Validation of all simulations indicates reliable patient-specific results.

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来源期刊

Journal of Cardiovascular Translational Research CARDIAC & CARDIOVASCULAR SYSTEMS-MEDICINE, RESEARCH & EXPERIMENTAL

CiteScore

6.10

自引率

2.90%

发文量

148

审稿时长

6-12 weeks

期刊介绍： Journal of Cardiovascular Translational Research (JCTR) is a premier journal in cardiovascular translational research. JCTR is the journal of choice for authors seeking the broadest audience for emerging technologies, therapies and diagnostics, pre-clinical research, and first-in-man clinical trials. JCTR''s intent is to provide a forum for critical evaluation of the novel cardiovascular science, to showcase important and clinically relevant aspects of the new research, as well as to discuss the impediments that may need to be overcome during the translation to patient care.