Journal of Biomimetics, Biomaterials and Tissue Engineering最新文献_第8页

Microwave Sintering of Al2O3 Fiber-Reinforced Hydroxyapatite Matrix Composites 微波烧结Al2O3纤维增强羟基磷灰石基复合材料

Journal of Biomimetics, Biomaterials and Tissue Engineering Pub Date : 2012-07-01 DOI: 10.4028/www.scientific.net/JBBTE.13.91

N. Ehsani, A. Ruys, C. Sorrell

引用次数: 4

Integrated Motile Orbital Implants Based on Ceramic Foam Scaffolds: Preparation and In Vivo Study 基于陶瓷泡沫支架的集成运动眶植入物:制备及体内研究

Journal of Biomimetics, Biomaterials and Tissue Engineering Pub Date : 2012-07-01 DOI: 10.4028/www.scientific.net/JBBTE.13.41

O. Smorygo, V. Krasilnikova, Yuri Vialiuha, V. Goranov, Yu. I. Kovalenko, L. Tsedik

引用次数: 0

Venation-Like Rib Layout Design in Plate under Bending Loads 弯曲荷载作用下板的类脉络布置设计

Journal of Biomimetics, Biomaterials and Tissue Engineering Pub Date : 2012-07-01 DOI: 10.4028/www.scientific.net/JBBTE.13.31

Kai Xue, Yong Xin Li, Wei Wang

引用次数: 6

Interaction of Yeast Cells with Nanoparticles - an FTIR Study 酵母细胞与纳米颗粒相互作用的FTIR研究

Journal of Biomimetics, Biomaterials and Tissue Engineering Pub Date : 2012-07-01 DOI: 10.4028/www.scientific.net/JBBTE.14.65

M. Mukherjee, A. Gangopadhyay, N. Das, A. Sarkar

{"title":"Interaction of Yeast Cells with Nanoparticles - an FTIR Study","authors":"M. Mukherjee, A. Gangopadhyay, N. Das, A. Sarkar","doi":"10.4028/www.scientific.net/JBBTE.14.65","DOIUrl":"https://doi.org/10.4028/www.scientific.net/JBBTE.14.65","url":null,"abstract":"In the present work, samples were prepared allowing yeast to grow simply on YPDA-agar medium at a particular incubation temperature using streaking procedure. Doped specimens of yeast were prepared using YPDA-agar medium in presence of ZnO and TiO2 nanoparticles in a nutrient medium for yeast. ZnO and TiO2 nanoparticles for delivery over yeast cell were prepared with Gum Arabica and Ethanol (CH3CH2OH) respectively as capping agent. Specimens were also developed by laser irradiation on the ZnO doped nanoclusters and pure yeast. FTIR spectroscopy was employed to investigate the effects of nanoclusters and laser irradiation over yeast cell under different conditions. Application of laser irradiation exhibits some positive effect on pure yeast. Effect of ZnO and TiO2 nanocluster doping on yeast are found to be toxic over Yeast Amide in general. Laser irradiation on nanocluster doped yeast cell enhanced the toxicity of nanoclusters. The later part of this study confirms the destruction of Amides in yeast. This preliminary work is an in-vivo application of drug delivery principle using ZnO nanocluster in Gum Arabica background.","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"7 1","pages":"65 - 73"},"PeriodicalIF":0.0,"publicationDate":"2012-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72819776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cell-Secreted Matrices Enhance Osteogenesis in Adipose-Derived Stem Cells Undergoing Lineage Specification 细胞分泌基质促进脂源性干细胞的成骨

Journal of Biomimetics, Biomaterials and Tissue Engineering Pub Date : 2012-07-01 DOI: 10.4028/www.scientific.net/JBBTE.14.1

H. Coan, T. Teli, C. Booth, M. Lively, M. V. Van Dyke

{"title":"Cell-Secreted Matrices Enhance Osteogenesis in Adipose-Derived Stem Cells Undergoing Lineage Specification","authors":"H. Coan, T. Teli, C. Booth, M. Lively, M. V. Van Dyke","doi":"10.4028/www.scientific.net/JBBTE.14.1","DOIUrl":"https://doi.org/10.4028/www.scientific.net/JBBTE.14.1","url":null,"abstract":"Osteogenic differentiation of mesenchymal stem cells (MSC) is important in the field of bone tissue engineering. The identification of biological factors that influence osteogenesis is vital for developing a broader understanding of how complex microenvironments play a role in differentiation. The aim of this study was to demonstrate that adipose-derived stem cell (ADSC) osteogenesis is enhanced through interaction with extracellular matrices (ECM) secreted by ADSC undergoing osteogenesis. ADSC were obtained from human patients following elective abdominoplasty. Cells were selected for plastic adherence, characterized, and induced to differentiate using osteogenic supplements (OS; dexamethasone, ascorbic acid, and beta-glycerol phosphate). Cells were removed at several time points during osteogenesis and the secreted ECM was isolated. Undifferentiated cells were re-seeded onto the cell secreted ECMs and induced to differentiate with OS. At several time points, cells cultured on ECMs or tissue culture plastic controls (i.e. uncoated surface) were collected and RNA isolated. QPCR and gene array analysis revealed enrichment of osteogenic markers and more rapid progression through osteogenic maturational phases in cells seeded onto ECM secreted at the midpoint in differentiation (ca. 15 days). Our results demonstrate that the cumulative deposition of ECM reaches a critical point at approximately 15 days, before which there appear to be no definitive osteogenic cues from the matrix, and after which, strong drivers of osteogenesis are present. The creation of microenvironments that contain essential morphogenic matrix signals is an important step towards methods of growing and differentiating MSC in a rapid effective manner, particularly for bone-related clinical applications.","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"1537 1","pages":"1 - 30"},"PeriodicalIF":0.0,"publicationDate":"2012-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87835713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Molecular Biocompatibility Evaluation of Poly-L-Ornithine-Coated Alginate Microcapsules by Investigating mRNA Expression of Pro-Inflammatory Cytokines 通过研究促炎细胞因子mRNA表达评价聚l -鸟氨酸包被海藻酸盐微胶囊的分子生物相容性

Journal of Biomimetics, Biomaterials and Tissue Engineering Pub Date : 2012-07-01 DOI: 10.4028/www.scientific.net/JBBTE.14.53

A. Chen, Yan Bai, Shi-Bin Wang, Yuangang Liu, Z. Chen

{"title":"Molecular Biocompatibility Evaluation of Poly-L-Ornithine-Coated Alginate Microcapsules by Investigating mRNA Expression of Pro-Inflammatory Cytokines","authors":"A. Chen, Yan Bai, Shi-Bin Wang, Yuangang Liu, Z. Chen","doi":"10.4028/www.scientific.net/JBBTE.14.53","DOIUrl":"https://doi.org/10.4028/www.scientific.net/JBBTE.14.53","url":null,"abstract":"Following a polyelectrolytical complex reaction, the poly-L-ornithine (PLO)-alginate microcapsules were prepared by coating PLO on calcium alginate beads which were produced by a high-voltage electrostatic droplet generator. The biocompatibility of the microcapsules at the molecular level was evaluated through investigating the mRNA expression of pro-inflammatory cytokines; that is, the effect of the PLO coating of alginate beads on the mRNA expression of TNF-α, IL-1β, and IL-6 were measured using the RT-PCR method. The resulting PLO-coated alginate microcapsules have a smooth surface with a mean diameter of 309µm. The molecular biocompatibility studies show that coating microcapsules with PLO has no significant effect on the biocompatibility of alginate microcapsules (p>0.05), and both alginate microcapsules and PLO-coated microcapsules are significantly different from the positive control (p<0.05); however, both are also capable of causing an inflammatory response at a molecular level since both are significantly different from the blank control (p<0.05). Furthermore, with the increase in concentration of microcapsules or co-cultured time, part of the mRNA expression of cytokines is significantly increased. The results also demonstrate that the method used in this study, co-incubating the microcapsules with macrophages and measuring the mRNA expression of cytokines by RT-PCR, may be a useful method for evaluating the biocompatibility of coating materials of microcapsules.","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"5 1","pages":"53 - 64"},"PeriodicalIF":0.0,"publicationDate":"2012-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78691055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Biomechanical Evaluation of Different Techniques in Double Bundle Anterior Cruciate Ligament Reconstruction Using Finite Element Analysis 有限元分析对双束前交叉韧带重建不同技术的生物力学评价

Journal of Biomimetics, Biomaterials and Tissue Engineering Pub Date : 2012-07-01 DOI: 10.4028/www.scientific.net/JBBTE.13.55

Rongying Huang, Hongguang Zheng, Qiang Xu

{"title":"Biomechanical Evaluation of Different Techniques in Double Bundle Anterior Cruciate Ligament Reconstruction Using Finite Element Analysis","authors":"Rongying Huang, Hongguang Zheng, Qiang Xu","doi":"10.4028/www.scientific.net/JBBTE.13.55","DOIUrl":"https://doi.org/10.4028/www.scientific.net/JBBTE.13.55","url":null,"abstract":"Anterior cruciate ligament injuries commonly in traffic accident, sports activities and extreme sports. Anterior cruciate ligament reconstruction is a common practice to help the patients restore the knee stability. However, there is no previous comparison study of single bundle reconstruction, double-femoral double-tibial tunnel reconstruction, single-femoral double-tibial tunnel reconstruction, and double-femoral single-tibial tunnel reconstruction with respect to biomechanical characteristics such as rotational stability, force and stress inside the ligament and grafts, stresses inside the soft tissues. In this study, we developed a pair of three-dimensional finite element models of a lower extremity including femur, tibia, fibula, cartilage, meniscus, and four major ligaments at 0°，25°，60° and 80°of knee flexion. Based on the intact models, single bundle reconstruction, double-femoral double-tibial tunnel reconstruction, single-femoral double-tibial tunnel reconstruction, and double-femoral single-tibial tunnel reconstruction models were also developed. Then, the anterior tibial translations, the forces and stresses inside the ACL and ACL replacements, as well as the stresses inside the menisci, femoral and tibial cartilage were predicted under a combined rotatory load of 10Nm valgus moment and 5 Nm internal torque, respectively using finite element analysis. The rotational stability, ligament forces and stresses in the menisci, femoral and tibial cartilage following double bundle augmentation were superior to the other reconstruction techniques, while there is little advantage in ligament stress compared to that of the single bundle reconstruction. We conclude that double-femoral double-tibial tunnel reconstruction may have advantages with regard to biomechanical characteristics such as rotational stability, force inside the ligament and grafts, stresses inside the soft tissues.","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"24 1","pages":"55 - 68"},"PeriodicalIF":0.0,"publicationDate":"2012-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80914133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Densification and Hardness Behaviour of Nanocrystalline Hydroxyapatite/β-Tricalcium Phosphate Composite Powders 纳米羟基磷灰石/β-磷酸三钙复合粉体的致密化和硬度行为

Journal of Biomimetics, Biomaterials and Tissue Engineering Pub Date : 2012-07-01 DOI: 10.4028/www.scientific.net/JBBTE.14.81

B. Mehdikhani, B. Mirhadi

引用次数: 2

Formation of Calcium Phosphate-Ellagic Acid Composites by Layer by Layer Assembly for Cellular Attachment to Osteoblasts 磷酸钙-鞣花酸复合材料在成骨细胞上的逐层组装

Journal of Biomimetics, Biomaterials and Tissue Engineering Pub Date : 2012-07-01 DOI: 10.4028/www.scientific.net/JBBTE.13.1

I. Banerjee, K. Fath, Nako Nakatsuka, Nazmul H. Sarker, I. Banerjee

{"title":"Formation of Calcium Phosphate-Ellagic Acid Composites by Layer by Layer Assembly for Cellular Attachment to Osteoblasts","authors":"I. Banerjee, K. Fath, Nako Nakatsuka, Nazmul H. Sarker, I. Banerjee","doi":"10.4028/www.scientific.net/JBBTE.13.1","DOIUrl":"https://doi.org/10.4028/www.scientific.net/JBBTE.13.1","url":null,"abstract":"The quest for new biomaterials to serve as cell scaffolds for applications in tissue engineering is of prime importance. In this work, we investigated microfiber assemblies of Ellagic Acid (EA), a plant polyphenol to serve as scaffolds for attachment and proliferation of osteoblasts. The advantage of Ellagic Acid self-assembling system is its intrinsic ability to order into multiple layers due to its capability to form liquid crystalline assemblies. We prepared ellagic acid-microfiber composites by the layer-by-layer (LBL) assembly method, where collagen (COL), poly-Arginine (poly-R), and calcium phosphate nanocrystals were coated on the surface of ellagic acid microfibers. The attachment of the various layers was confirmed by various spectroscopic and microscopic methods. The samples were found to be porous with an average pore size of 600 nm. The formed microconjugates were biodegradable and supported the growth of human fetal osteoblast (hFOB) cells in vitro. Our findings suggest that this system not only promotes initial cell adhesion but also can be utilized to deliver the vital biological molecule ellagic acid to cells at the scaffold interface and displays a new strategy for the design of biomaterials.","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"11 1","pages":"1 - 17"},"PeriodicalIF":0.0,"publicationDate":"2012-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87320248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biodegradable Magnesium Alloys: A Review of Material Development and Applications. 可生物降解镁合金：材料开发与应用综述。

Journal of Biomimetics, Biomaterials and Tissue Engineering Pub Date : 2012-02-03 DOI: 10.4028/www.scientific.net/JBBTE.12.25

Dharam Persaud-Sharma, Anthony McGoron

引用次数: 0