Journal of Ayurveda and Integrative Medicine最新文献

{"title":"Long-term disease-free survival of a patient diagnosed with peri-ampullary carcinoma treated with adjunct Ayurvedic treatment – A case report","authors":"Sadanand Sardeshmukh,&nbsp;Vineeta Deshmukh,&nbsp;Swapna Kulkarni,&nbsp;Vasanti Godse,&nbsp;Vinita Awalkanthe,&nbsp;Shreenivas Datar,&nbsp;Shweta Gujar,&nbsp;Sandeep Chavan","doi":"10.1016/j.jaim.2024.101111","DOIUrl":"10.1016/j.jaim.2024.101111","url":null,"abstract":"<div><div>This is a case of a female Indian patient diagnosed as Peri-Ampullary Carcinoma, with metastasis to regional lymph nodes, and reported 5-year disease free survival rate of 20–50%, treated with integration of personalized Ayurvedic treatment along with conventional treatments viz., surgery and adjuvant chemotherapy.</div><div>The patient was diagnosed with adenocarcinoma through biopsy from the ampulla of Vater during registration at our Centre in May 2010. She had yet to start her conventional treatment which was advised viz., surgery and adjuvant chemotherapy. In June 2010, she underwent Whipple's resection. Histopathology report showed moderately differentiated adenocarcinoma of the periampullary region with metastasis to regional lymph nodes — Completely resected (R0). According to TNM (Tumor Node Metastasis) Staging System as per Union for International Cancer Control (UICC- 6th edition) patient was staged as pT3N1- Stage IIB. After completion of conventional treatment (surgery and chemotherapy) in October 2010, she continued with Ayurvedic treatment and follow-ups till date. Her tumour marker CA19.9 and sonography – abdomen, pelvis after 12 years revealed no evidence of malignancy. In May 2017, she was hospitalized for hematemesis and melena, diagnosed as mild gastritis with clean base ulcers at the surgical anastomosed (Gastrojejunostomy) site. She was treated accordingly with Ayurvedic medicines and her follow-up report showed the resolution of ulcers by September 2017. In May 2014, her mildly raised blood sugar (Fasting 138 mg/dL; Post-Prandial 146 mg/dL) was managed by a healthy lifestyle but in 2019, her blood glucose levels were moderately raised (Fasting 153 mg/dL, Post-Prandial 187 mg/dL) hence she was started on oral hypoglycemics which are continued till date.</div><div>Though the pancreaticobiliary subtype is associated with poor prognosis, it was possible to achieve 12 years and 6 months of disease-free survival with adjunct Oral Ayurvedic Medicines (OAM) possessing antioxidant, immune-modulatory, anti-cancer, and hepato-protective action. She could tolerate chemotherapy with minimal side effects. Her quality of life improved. Her blood sugar levels have been maintained by lifestyle changes and oral hypoglycemics.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101111"},"PeriodicalIF":1.9,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144888801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unravelling AYUSH providers’ perspectives on healthcare choices of people residing in urban areas of Puducherry, India- A concurrent mixed method study","authors":"Anusha Seelamantula ,&nbsp;Premarajan K C ,&nbsp;Mahalakshmy Thulasingam","doi":"10.1016/j.jaim.2025.101180","DOIUrl":"10.1016/j.jaim.2025.101180","url":null,"abstract":"<div><h3>Background</h3><div>The rising popularity of alternative medicine positions AYUSH (Ayurveda, Yoga &amp; Naturopathy, Unani, Siddha, and Homoeopathy) systems as valuable tools for providing affordable, culturally appropriate healthcare to low-middle-income countries. However, overcoming the challenges of scaling up these traditional systems is key to gaining broader acceptance of this promising healthcare approach.</div></div><div><h3>Objectives</h3><div>To determine the prevalence and associated factors of AYUSH utilization. And, to explore the perceptions of AYUSH providers on factors supporting or hindering AYUSH adoption, and its integration with conventional medicine.</div></div><div><h3>Material and methods</h3><div>A concurrent mixed-method study was employed between September and December 2023. Prevalence of AYUSH utilization was assessed via door-to-door survey using pre-tested questionnaire. Ten key informant interviews were conducted among AYUSH practitioners and analyzed using thematic analysis.</div></div><div><h3>Results</h3><div>Prevalence of AYUSH utilization was 19.2% (95% CI:16.9% – 21.6%). A significant association among people with comorbidities (aPR: 1.5; 95% CI: 1.0–2.1; <em>P</em>-value&lt;0.05) is observed. Qualitative analysis revealed that growing public interest and government support were key enablers, while limited scientific validation and workforce shortage were major barriers. From the health systems perspective, AYUSH providers spoke about the need for policy and governance reforms to create a more unified healthcare system.</div></div><div><h3>Conclusion</h3><div>Despite some challenges, the findings suggest that AYUSH is increasingly favoured for its natural approach. A growing acceptance of integrative medicine highlights the need for cohesive care models and improved accessibility. The study emphasizes the importance of addressing state-specific needs and standardizing AYUSH practices to facilitate integration.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101180"},"PeriodicalIF":1.9,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144885778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prakriti elucidates the inter-individual variability in coronary artery disease risk-predicting biomarkers: A tertiary care hospital-based case control study","authors":"Pamila Dua ,&nbsp;Bhavana Prasher ,&nbsp;Sandeep Seth ,&nbsp;Shivam Pandey ,&nbsp;Subir Kumar Maulik ,&nbsp;K.H. Reeta","doi":"10.1016/j.jaim.2025.101178","DOIUrl":"10.1016/j.jaim.2025.101178","url":null,"abstract":"<div><h3>Background</h3><div>Several biochemical tests and biomarkers are well-known for the assessment of risk towards coronary artery disease (CAD). However, conflicting results pose a significant challenge probably due to phenotypic heterogeneity. In Ayurveda, individuals are classified into phenotypes- <em>Prakriti,</em> which helps in predicting an individual's susceptibility to disease, its prognosis and selection of therapy. In the present study, an attempt was made to overcome this challenge with an aim to identify the association between different constitution types as mentioned in Ayurveda with biochemical markers for precisely predicting the risks for CAD.</div></div><div><h3>Methods</h3><div>200 clinically stable CAD patients and 100 healthy controls were recruited from the Cardiology OPD, AIIMS, New Delhi, India. A comprehensive set of tests to incorporate various aspects of CAD pathophysiology was performed. Assessment of <em>Prakriti</em> was done clinically and with AI/ML algorithm based validated questionnaire.</div></div><div><h3>Results</h3><div>The monocyte-lymphocyte ratio (MLR), fasting blood sugar, urea, creatinine, uric acid, and NT-pro BNP were significantly higher in CAD patients as compared to healthy controls. <em>Prakriti</em> stratification revealed maximum number of patients with <em>Kapha Prakriti</em>. MLR and IL-6 (associated with inflammatory and peripheral endothelial dysfunction) were high in <em>Vata</em> patients; diabetic control (associated with plaque instability and malfunctioned RAAS) was poor in <em>Kapha</em> patients and NT-pro BNP (associated with myocardial hypoxia) was higher in <em>Pitta</em> patients.</div></div><div><h3>Conclusion</h3><div>Though, several biochemical parameters were associated with risks for CAD, <em>Prakriti</em> classification provided more insights into the precise risks. This dual approach may help in guiding personalized treatment options in CAD management.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101178"},"PeriodicalIF":1.9,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144865078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of an instrument for screening mental health based on Ayurvedic concept of Triguna","authors":"K.N. Ananda Lakshmy ,&nbsp;M.A. Shajahan","doi":"10.1016/j.jaim.2025.101175","DOIUrl":"10.1016/j.jaim.2025.101175","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;As the bio-regulatory principles (&lt;em&gt;Dosha&lt;/em&gt;) are the essential components of the body, the three attributes (&lt;em&gt;Triguna&lt;/em&gt;)-&lt;em&gt;Satva, Raja&lt;/em&gt;, and &lt;em&gt;Tamas&lt;/em&gt; are the crucial components of the mind that determine an individual's mental status. Though &lt;em&gt;Triguna&lt;/em&gt;-based psychological assessment tools are available, there are no standardized tools to evaluate mental health using this unique Ayurvedic approach.So this research was undertaken to create a simple, self-administering instrument for screening mental health based on Ayurvedic concept-&lt;em&gt;Triguna&lt;/em&gt;.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To develop a simple, reliable, and valid self-administering instrument based on &lt;em&gt;Triguna&lt;/em&gt; concept of Ayurvedic classics for screening mental health.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Standard steps to develop the instrument -Conceptualization, item generation, item selection, item wording, Translation-back translation, pre-test, pilot study, Test-retest were done before the final administration of the draft instrument. Reliability and validity testing were carried out. Reliability assessment included Test-retest and internal consistency. Face, content, construct, criterion and convergent validity were done as part of the validity assessment. Exploratory factor analysis using Principal Component Analysis with Varimax rotation was employed for construct validation and item reduction. A cross-sectional study employing a stratified, multi-stage cluster sampling technique was conducted among 400 participants aged 20–40 years, representing rural, urban and coastal areas of Thiruvananthapuram, Kerala, India. The criterion validity of the newly developed tool was assessed against the WHO Subjective Well-being Inventory(SUBI).The reference standard, evaluated for its diagnostic properties including sensitivity, specificity, predictive values, and likelihood ratios, was administered alongside the draft instrument. After appropriate analyses, a 38-item self-administering instrument was developed and named as Mental Health Assessment Scale with &lt;em&gt;Triguna&lt;/em&gt; (MHAS-TG). Hypothesis validation and construct validity were assessed using diverse community samples, comprising 100 individuals from various geographical areas of Kannur District, 100 students from NIT Calicut (Kozhikode) and 50 ex-convicts from Kannur District.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;The newly developed 38-item Mental Health self-Assessment Scale with &lt;em&gt;Triguna&lt;/em&gt; (MHAS-TG) is presented as a discriminating tool that showed high Test-retest (Intra Class Correlation coefficient - 0.8) and Internal consistency reliability (Cronbach's alpha = 0.9). The tool had adequate face validity and content validity (Content validity index- 0.84). Construct validity by Exploratory factor analysis yielded 38 items of 9-factor solution with a cumulative variance of 58.06 %. The self-administering tool with a score range of 0–114 derived a cut-off sc","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101175"},"PeriodicalIF":1.9,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144779299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translating Ayurvedic concepts to modern drug structures: A novel paradigm","authors":"Antonio Morandi ,&nbsp;Maria Cristina Minniti ,&nbsp;AN Narayanan Nambi","doi":"10.1016/j.jaim.2025.101203","DOIUrl":"10.1016/j.jaim.2025.101203","url":null,"abstract":"<div><div>Modern pharmacology faces challenges in fully explaining inter-individual variability in drug efficacy and side effects. This article introduces a groundbreaking approach that applies Ayurvedic principles to interpret modern drug structures and actions, offering a more comprehensive framework for understanding drug behavior. Through the Collaborative Medicine and Science (Co.M.S.) framework, we demonstrate how Ayurvedic epistemology provides a holistic reading of modern pharmaceuticals using fundamental principles of <em>Panchamahabhuta</em>, <em>Tridosha</em>, and <em>Guna</em>. This Ayurvedic interpretation reveals how drug effects (<em>Karma</em>) emerge from the interaction between a substance's inherent qualities (<em>Guna</em> profile) and an individual's constitutional context (<em>Prakriti</em>/<em>Vikriti)</em>, explaining inter-individual variability in drug responses. Illustrative examples using antibiotics and antihypertensives demonstrate how this approach can optimize prescription practices, reduce side effects, and lower healthcare costs. While empirical validation will strengthen this approach, it already offers valuable practical insights that complement—not replace—conventional pharmacology, potentially enhancing personalized medicine and patient outcomes.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101203"},"PeriodicalIF":1.9,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation on antineoplastic potential of Barleria lupulina Lindl: From phytochemical profiling to molecular dynamics simulation assessment","authors":"Sabyasachi Banerjee ,&nbsp;Avik Das ,&nbsp;Sankhadip Bose ,&nbsp;Subhasis Banerjee ,&nbsp;Anusha Bishayee ,&nbsp;Anupam Bishayee","doi":"10.1016/j.jaim.2025.101220","DOIUrl":"10.1016/j.jaim.2025.101220","url":null,"abstract":"<div><h3>Background</h3><div><em>Barleria lupulina</em>, a medicinal plant of India, South China and Southeast Asia, is known for its antioxidant and cytotoxic abilities. Although this plant has shown significant promise as an anticancer agent, the underlying mechanisms of action are yet to be explored. <em><strong>Objective</strong></em><strong>:</strong> This study aimed to assess antiproliferative and proapoptotic potential of <em>B. lupulina</em> leaf extract with understanding of cellular and molecular mechanisms.</div></div><div><h3>Materials and methods</h3><div>The ethanolic extract was characterized using liquid chromatography-mass spectrometry and its anticancer activity was then assessed against Caco-2 colon cancer and A549 lung cancer cell lines.</div></div><div><h3>Results</h3><div>Phytochemical analysis of the extract revealed the presence of acetylbarlerin, decaffeoylacteoside, gallic acid, ipolamiide, leonuriside A, shanzhiside, and vanillic acid. The extract showed concentration-dependent cytotoxicity against both cancer cells. It induced early apoptosis at lower concentrations and late apoptosis at higher concentrations. Moreover, the extract noticeably reduced reactive oxygen species and mitochondrial membrane potential in a concentration-dependent way. The Western blot and quantitative reverse transcription polymerase chain reaction showed upregulation of Bax, caspase-8, caspase-9, and cluster of differentiation 95, and downregulation of Bcl-2. Molecular docking studies revealed that decaffeoylacteoside, gallic acid, and vanillic acid exhibited dual affinities for both caspase-8 and caspase-9, while acetylbarlerin, ipolamiide, leonuriside A, and shanzhiside showed selective affinities only for caspase-9.</div></div><div><h3>Conclusion</h3><div>The ethanolic leaf extract shows significant cytotoxic and proapoptotic activities, confirming its potential as a useful resource of bioactive compounds against cancer. Nevertheless, more in-depth investigations are necessary to realize the full potential of this medicinal plant for cancer therapy.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101220"},"PeriodicalIF":1.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144723893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IFTAK technique for management of anterior fistulae in ano in female patients - A case series","authors":"K.T. Aadithyaraj,&nbsp;Rahul Sherkhane,&nbsp;Awadhesh Kumar Pandey,&nbsp;Sarika Solanki,&nbsp;Shivani Katkar","doi":"10.1016/j.jaim.2025.101170","DOIUrl":"10.1016/j.jaim.2025.101170","url":null,"abstract":"<div><div>Anterior fistula in ano is an uncommon and challenging condition in females, with sparse literature describing effective management strategies. Surgical interventions are often complicated by the anatomical intricacies of the pelvic region. This case series explores the use of the Interception of Fistulous Tract with the Application of Ksharasutra (IFTAK) technique, a modification of traditional Ksharasutra therapy, in managing anterior fistulae in ano among female patients. Three female patients with anterior anal fistulae, two with failed prior surgical interventions, were included. Comprehensive preoperative evaluations, including clinical and radiological assessments, were performed. The IFTAK technique was employed, emphasizing tract interception and eradication of sepsis without compromising the anal sphincter. All patients achieved complete healing within 8 weeks post-procedure. No recurrence, incontinence, or significant complications were observed during a 12-month follow-up. The IFTAK technique is a promising approach for anterior fistulae in ano in females, offering high success rates with minimal complications. While the results are encouraging, validation through well-designed randomized controlled trials is essential for its broader adoption as a standard treatment for complex anal fistulas.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101170"},"PeriodicalIF":1.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144703292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Swarna Bhasma reduces the blood concentration of tumor-specific signatures and protects from hepatocellular damages in Ehrlich ascites mice model","authors":"Namrata Joshi ,&nbsp;Pankaj Kumar ,&nbsp;Shiwakshi Sharma ,&nbsp;Remya Jayakumar ,&nbsp;Anand Mishra ,&nbsp;V. Harsha ,&nbsp;Manoj Kumar Dash","doi":"10.1016/j.jaim.2025.101152","DOIUrl":"10.1016/j.jaim.2025.101152","url":null,"abstract":"<div><h3><strong>Background</strong></h3><div>The paradigm shift with alarmingly high rate of global cancer incidences encourages the application of incinerated gold Nano powder, Swarna Bhasma (SB) due to its exceptional potency, affordability, and minimal toxic effects. Previous experimental investigations were unable to provide a biochemical understanding of the anti-carcinogenic properties of SB.</div></div><div><h3><strong>Objective</strong></h3><div>To evaluate the tumour related markers in blood and possible alteration in hepatic parameters due to SB.</div></div><div><h3><strong>Methods</strong></h3><div>EAC (Ehrlich’s Ascites Carcinoma) induced tumour was generated in the female Swiss albino mice divided into 6 groups, namely, Vehicle Control (VC), Disease Control (DC), Standard Control (SC), and Treatment Groups with escalating doses (1.95, 3.9, and 7.8 mg/kg body weight) of SB. Blood serum quantified was measured for the levels of CEA (Carcinoembryonic antigen), TNF-α (Tumour Necrosis Factoralpha), IL-6 (Interleukin-6), ALT (Alanine transaminase), and AST (Aspartate aminotransferase). Changes in daily food consumption, body weight, and tumour volume (with Vernier caliper) were coherently studied and analysed. The data was analysed using One-Way ANOVA and Tukey's Honest Significance Test.</div></div><div><h3><strong>Result</strong></h3><div>SB demonstrated effective reduction of CEA levels at higher doses, and TNF-α levels at medium doses. Both moderate and high doses exhibited a noteworthy, dosedependent decrease in IL-6 levels. Furthermore, SB led to a dose-dependent reduction in the AST/ALT ratio. A significant reduction in tumour volume were reported in both the moderate and high doses of SB along with marked improvement in anorexia. The higher doses of SB exhibited the serum validated results in the hepatic, renal and the splenic tissues.</div></div><div><h3><strong>Conclusion</strong></h3><div>The anti-carcinogenic activity of SB appeared to be dose-dependent. The finding also underscored the hepato-protective capability of SB in lower dose by alleviating cancer-related liver damage</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101152"},"PeriodicalIF":1.7,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144695020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Ayurvedic intervention for pseudomyxoma peritonei - A case report","authors":"Divya Sukumar,&nbsp;T. Sreekumar,&nbsp;P.V. Smitha Mohan,&nbsp;K. Shaji,&nbsp;A. Athulya","doi":"10.1016/j.jaim.2025.101166","DOIUrl":"10.1016/j.jaim.2025.101166","url":null,"abstract":"<div><div>Cancer is the deadliest disease in the world and cancer treatment remains as a challenge among all systems of medicine. Pseudomyxoma peritonei is one of the rarest malignancies, devoid of any promising management strategies. Ayurvedic perspective of diagnosis and reports on treatment strategies for such malignant conditions are highly limited. In this study, a male patient with pseudomyxoma peritonei, presented with breathlessness, abdominal distension, inguinal hernia and swelling of both legs with oozing. CT and biopsy reports diagnosed the disease as Pseudomyxoma Peritonei. He was provided with ayurvedic treatment for improving Quality of Life. <em>Paniya kshara</em> and <em>Bhallathaka vati</em> were the principal contents of the medication given. Other medications are <em>Punarnavadi kashaya, chirivilwadi kashaya</em>, Tab Neem, Tab <em>Haridra,</em> Cap <em>Rasasindoor</em> and Cap <em>Poornachandrodaya ras</em><em>a</em><em>.</em> After 90 days of treatment, patient got relief from breathlessness, leg swelling and oozing. The abdominal circumference also reduced remarkably from 108cm to 78cm, and the Quality of Life also improved. The treatment principle adopted was based on the concepts of <em>udara, arbuda</em> and <em>sopha</em>. Cautious combination of concepts from Ayurveda can provide effective treatment strategies to treat rare diseases.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101166"},"PeriodicalIF":1.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Panchakarma treatment for painful Post-Traumatic Trigeminal Neuropathy – A case report","authors":"Manoj Shamkuwar ,&nbsp;Kiran Nimbalkar ,&nbsp;Diwakar Mani Tripathi ,&nbsp;Bhavna Bhatia ,&nbsp;Manisha ,&nbsp;Rohit Pal","doi":"10.1016/j.jaim.2025.101168","DOIUrl":"10.1016/j.jaim.2025.101168","url":null,"abstract":"<div><div>Trigeminal Neuralgia (TN) is characterized by sudden, electric shock-like pain triggered by innocuous stimuli. Post-Traumatic Trigeminal Neuropathy (PTTN), a traumatic subset of TN, shares these features but also involves sensory abnormalities and psychological distress. Conventional treatments, including medications and surgical interventions, often provide limited relief and have their limitations. <em>Ayurveda</em> offers a more holistic, non-invasive alternative for long-term management. This case study details a 45-year-old male patient with right-sided facial pain persisting for eight months, unresponsive to conventional medications. Baseline pain intensity was six out of ten on the Numerical Rating Scale (NRS). The interventions comprised <em>Virechana</em> (therapeutic purgation)<em>, Ksheera-bashpa Swedana</em> (therapeutic steam of medicated milk), <em>Nasya</em> (medication through nasal route)<em>, Shirodhara</em> (therapeutic streaming over head)<em>,</em> and <em>Matra Basti</em> (a form of unctuous enema), followed by a seven-month course of medications. During the course of treatment, pain intensity gradually reduced from six to one on the NRS, accompanied by significant improvements in emotional well-being, sleep, and overall quality of life. Follow-up assessments confirmed sustained benefits, including a decreased dependence on conventional medication. This case highlights the potential of <em>Ayurveda</em> in PTTN management. More case reports and series of this kind are desirable for a better insight into this management approach.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 4","pages":"Article 101168"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144548589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}