Journal of Ayurveda and Integrative Medicine最新文献

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Simulating vagus nerve stimulation through Basti therapy: A novel approach to anti-inflammatory treatment in Parkinson's disease model 通过basi疗法模拟迷走神经刺激:帕金森病模型抗炎治疗的新方法。
IF 2.1
Journal of Ayurveda and Integrative Medicine Pub Date : 2026-09-01 Epub Date: 2026-10-01 DOI: 10.1016/j.jaim.2026.101417
Pratibha P. Nair, Arathi Radhakrishnan, Mukesh Edavalathu, Joyal L. Joy
{"title":"Simulating vagus nerve stimulation through Basti therapy: A novel approach to anti-inflammatory treatment in Parkinson's disease model","authors":"Pratibha P. Nair,&nbsp;Arathi Radhakrishnan,&nbsp;Mukesh Edavalathu,&nbsp;Joyal L. Joy","doi":"10.1016/j.jaim.2026.101417","DOIUrl":"10.1016/j.jaim.2026.101417","url":null,"abstract":"<div><div>Basti therapy, a key intervention in Ayurveda, is hypothesized to mimic the anti-inflammatory effects of vagus nerve stimulation (VNS) through modulation of the gut–brain axis. VNS is an established neuro-modulatory technique used in the management of inflammatory disorders. Parkinson's disease is considered a model to explore this hypothesis, given the significant role of vagal dysfunction and neuroinflammation in its pathogenesis. A structured literature search of major biomedical databases (2000–2025) was conducted to identify relevant studies on vagus nerve activity, gut–brain communication, and Basti therapy. The synthesized evidence suggests that Basti may influence gut mucosa, microbiota, and enteric–neural pathways, thereby modulating vagal signalling and inflammatory responses. The Ayurvedic concept of Vata Dosha shows functional parallels with vagus nerve activity, indicating that therapies targeting Vata may exert effects analogous to VNS. Based on this, it is proposed that Basti therapy may alter Vata Dosha status and engage neuroimmune mechanisms comparable to those activated by VNS. This hypothesis warrants further validation through experimental and clinical studies that assess vagal activity and inflammatory biomarkers and may provide a basis for integrative approaches to neurodegenerative disorders.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 5","pages":"Article 101417"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the potential benefits of Shirodhara as an add-on therapy for alleviating post-COVID anxiety and depression: A case study 探索Shirodhara作为缓解covid后焦虑和抑郁的附加疗法的潜在益处:一项案例研究
IF 2.1
Journal of Ayurveda and Integrative Medicine Pub Date : 2026-09-01 Epub Date: 2026-10-10 DOI: 10.1016/j.jaim.2026.101407
Manoj Shamkuwar, Anandaraman PV, Dinesh Kataria, Santosh Bhatted, Bhavna Bhatia
{"title":"Exploring the potential benefits of Shirodhara as an add-on therapy for alleviating post-COVID anxiety and depression: A case study","authors":"Manoj Shamkuwar,&nbsp;Anandaraman PV,&nbsp;Dinesh Kataria,&nbsp;Santosh Bhatted,&nbsp;Bhavna Bhatia","doi":"10.1016/j.jaim.2026.101407","DOIUrl":"10.1016/j.jaim.2026.101407","url":null,"abstract":"<div><div>In this case study, we present a 31-year-old female, a homemaker, who developed persistent symptoms of anxiousness, fatigue, weakness, irritation, anger issues, and difficulty concentrating for nearly 12 months following recovery from COVID-19. She was diagnosed by a consulting psychiatrist with post-COVID anxiety with depression, and had been on anxiolytic and antidepressant medications for the past ten months. She underwent <em>Shirodhara</em> (dripping of medicated oil on the forehead) using <em>Balashwagandhadi taila</em> for 14 days as an add-on therapy, while continuing her conventional medications. Assessments at baseline, 8th day, 15th day, and 30th day showed progressive improvements: Hamilton Anxiety Rating Scale (HAM-A) scores reduced from 42 to 10, Hamilton Depression Rating Scale (HDRS) from 23 to 6, Patient Health Questionnaire-9 (PHQ-9) from 24 to 1, and Flanagan Quality of Life Scale (QOLS) improved from 59 to 79 by the 30th day. Serum cortisol was 3.09 μg/dL at baseline, below the normal range, and returned to the normal physiological range (11.76 μg/dL) on the 15th day, reflecting improved stress adaptation. C-Reactive Protein remained stable, while Systemic Immune-Inflammation Index showed a transient, non-pathological rise within normal limits. Also, based on the evaluation and recommendation of the psychiatrist, the dosage of conventional medications was reduced: Propranolol was tapered from 20 mg twice daily to once daily, Clonazepam 0.5 mg at bedtime was shifted to as-needed use, and Omeprazole was discontinued. This case highlights the potential role of <em>Shirodhara</em> as an adjunctive therapy in post-COVID anxiety, along with depression. These findings require validation through larger studies with long-term follow-up.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 5","pages":"Article 101407"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149140894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ayurvedic approaches to scorpion stings: Historical insights, modern scientific perspectives and challenges 阿育吠陀方法蝎子蜇伤:历史的见解,现代科学的观点和挑战。
IF 2.1
Journal of Ayurveda and Integrative Medicine Pub Date : 2026-09-01 Epub Date: 2026-10-13 DOI: 10.1016/j.jaim.2026.101397
Susmita Nath, Naba K. Hazarika, Ashis K. Mukherjee
{"title":"Ayurvedic approaches to scorpion stings: Historical insights, modern scientific perspectives and challenges","authors":"Susmita Nath,&nbsp;Naba K. Hazarika,&nbsp;Ashis K. Mukherjee","doi":"10.1016/j.jaim.2026.101397","DOIUrl":"10.1016/j.jaim.2026.101397","url":null,"abstract":"<div><div>Scorpion stings are medical emergencies that require immediate attention and are frequently overlooked. Commercial antivenom available only in India is for a single species of venomous scorpion, with significant limitations. Additionally, access to antivenom therapy is limited in rural areas. Examining the ancient Indian traditional medicine, Ayurveda, reveals insights into the underlying mechanisms of scorpion envenomation and potential treatments. Thus, this study examines the Ayurvedic treatment of scorpion stings from a historical and traditional viewpoint and a modern scientific standpoint, noting its shortcomings and recommending topics for further investigation. This study used a narrative integrative review approach. Relevant literature was searched in Google Scholar, PubMed, and Scopus using the terms ‘Ayurveda,’ ‘Traditional Indian medicine’, ‘scorpion sting treatment’, and ‘<em>Vrishchika Damsha’</em>. Classical Ayurvedic texts, ethnomedicinal reports, preclinical studies, and selected clinical accounts were reviewed and summarized to relate traditional Ayurvedic concepts to current knowledge on scorpion envenomation. However, Ayurvedic knowledge of '<em>Vrishchika Damsha'</em> (scorpion sting) focused only on the history and Ayurvedic perspective on scorpions, as well as on approaches to treating scorpion envenomation in India. The study showed that <em>Agada Tantra</em>, a specialized branch of Ayurvedic Toxicology, focuses on understanding and treating various toxins, including those produced by scorpions (<em>Vrishchika</em>). Ayurvedic texts provide detailed descriptions of scorpion sting symptoms and categorize the venom type as <em>Manda visha</em> (mild), <em>Madhya visha</em> (moderate), <em>and Ugra visha</em> (highly venomous) based on its toxicity. Ayurvedic classics such as <em>Susihruta Samhita, Agnivesha Samhita</em>, and <em>Charak Samhita</em> outline various treatment approaches for <em>Vrishchika Damsha</em>, including ointments, tablets, fumigation techniques, sudation therapy, chants, and herbal solvents. Significant gaps in knowledge regarding the effectiveness, safety, and standardization of Ayurvedic treatments remain, so a more in-depth investigation is needed to examine its potential for treating scorpion stings and assess its limitations through a modern scientific lens. This study will help identify knowledge gaps, ensuring a more evidence-based integration of traditional and contemporary healthcare methods.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 5","pages":"Article 101397"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of infusing ghee with Ayurvedic herb mix (Murchana) on its oxidative stability and its comparative analysis with medicated ghee (Siddha Ghrita) 印度草药混合物(Murchana)对印度酥油氧化稳定性的影响及其与药物酥油(Siddha Ghrita)的对比分析
IF 2.1
Journal of Ayurveda and Integrative Medicine Pub Date : 2026-09-01 Epub Date: 2026-09-18 DOI: 10.1016/j.jaim.2026.101401
Deepshikha Kataria, Madhuri N. Hegde, Gurmeet Singh
{"title":"Effect of infusing ghee with Ayurvedic herb mix (Murchana) on its oxidative stability and its comparative analysis with medicated ghee (Siddha Ghrita)","authors":"Deepshikha Kataria,&nbsp;Madhuri N. Hegde,&nbsp;Gurmeet Singh","doi":"10.1016/j.jaim.2026.101401","DOIUrl":"10.1016/j.jaim.2026.101401","url":null,"abstract":"<div><h3>Background</h3><div>The preparation of medicated <em>ghee</em>, known as <em>siddha ghrita</em> in Ayurveda, faces significant challenges due to lipid susceptibility to oxidation, which reduces shelf life and potentially leads to the loss of bioactive compounds. A popular lipid-stabilization process, <em>murchana</em>, has been recommended in Ayurveda as a pre-treatment for <em>ghee</em> with an Ayurvedic herb mix, which may improve its stability.</div></div><div><h3>Objective</h3><div>This study investigates the effect of <em>murchana</em> process on the oxidative stability of <em>Centella asiatica</em> (CA) <em>ghee</em>.</div></div><div><h3>Materials and Methods</h3><div>Plain <em>ghee</em> (PG), <em>murchit ghee</em> (MG), CA with PG (PGCA), and CA with MG (MGCA) were assessed for their oxidative stability via peroxide value (PV) and Rancimat induction time. Physicochemical properties (granulation, saponification value, color, free fatty acids), antioxidant capacity (DPPH-RSA), and Total Polyphenolic Content (TPC) were evaluated over 160 days at 45 °C, 85% RH.</div></div><div><h3>Results</h3><div>MGCA showed higher oxidative stability (PV: 6.49 vs. safe limit of 10 m.eq. O<sub>2</sub>/kg), longer induction time (MGCA: 38.8 h vs. PGCA: 24.32 h as measured by Rancimat), higher TPC (273.27 μg GAE/g), and antioxidant activity (DPPH-RSA: 5.37%) compared to PGCA. No detectable cholesterol oxidation products (COPs) were observed under the TLC conditions employed.</div></div><div><h3>Conclusion</h3><div>The results indicated that the <em>murchana</em> process delayed rancidity and enhanced the oxidative stability of the medicated ghee. However, the underlying phytochemical changes were not directly investigated in this study. Further studies are warranted to elucidate the contribution of these changes to the oxidative stability and therapeutic potential of Ayurvedic medicated ghee preparations.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 5","pages":"Article 101401"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148995749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ayurvedacharya K. Kunjuraman Vaidyar: A Kerala-based Physician-Academician and Gandhian Apostle, synthesizing Ayurveda with modern clinical insights 阿育吠陀arya K. Kunjuraman Vaidyar:喀拉拉邦的医师院士和甘地使徒,将阿育吠陀与现代临床见解相结合。
IF 2.1
Journal of Ayurveda and Integrative Medicine Pub Date : 2026-09-01 Epub Date: 2026-10-14 DOI: 10.1016/j.jaim.2026.101403
C.K. Saniya, G.N. Sree Deepthi, T.P. Sinimol, A. Abhayadev
{"title":"Ayurvedacharya K. Kunjuraman Vaidyar: A Kerala-based Physician-Academician and Gandhian Apostle, synthesizing Ayurveda with modern clinical insights","authors":"C.K. Saniya,&nbsp;G.N. Sree Deepthi,&nbsp;T.P. Sinimol,&nbsp;A. Abhayadev","doi":"10.1016/j.jaim.2026.101403","DOIUrl":"10.1016/j.jaim.2026.101403","url":null,"abstract":"","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 5","pages":"Article 101403"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medical editors and TCIM literature: Responsibilities and judgements. 医学编辑和TCIM文献:责任和判断。
IF 2.1
Journal of Ayurveda and Integrative Medicine Pub Date : 2026-07-24 DOI: 10.1016/j.jaim.2026.101408
Sarika Chaturvedi, Bhushan Patwardhan
{"title":"Medical editors and TCIM literature: Responsibilities and judgements.","authors":"Sarika Chaturvedi, Bhushan Patwardhan","doi":"10.1016/j.jaim.2026.101408","DOIUrl":"https://doi.org/10.1016/j.jaim.2026.101408","url":null,"abstract":"","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":" ","pages":"101408"},"PeriodicalIF":2.1,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148584396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ayurvedic management of grade III medial meniscal injury: A case report 阿育吠陀治疗III级内侧半月板损伤1例报告。
IF 2.1
Journal of Ayurveda and Integrative Medicine Pub Date : 2026-07-01 Epub Date: 2026-07-22 DOI: 10.1016/j.jaim.2026.101374
Manorma Singh, Poonam Garg, Ritu Thakur
{"title":"Ayurvedic management of grade III medial meniscal injury: A case report","authors":"Manorma Singh,&nbsp;Poonam Garg,&nbsp;Ritu Thakur","doi":"10.1016/j.jaim.2026.101374","DOIUrl":"10.1016/j.jaim.2026.101374","url":null,"abstract":"<div><div>Tear of grade III in the posterior horn of medial meniscus is a serious knee injury. Arthroscopic surgery is usually advised to manage these cases with variable outcomes. A female housewife aged 32 years, presented with the complaints of pain, stiffness, swelling and occasional giving way of the left knee joint for 2 months; at outdoor patient department of <em>Shalya Tantra</em> (surgery) of our hospital, India on 02/05/2022. There was history of fall from stairs 2 months back. MRI findings were suggestive of grade III tear of posterior horn of medial meniscus extending up to inferior surface. She was advised arthroscopic surgery. Due to financial constraints, surgery was not opted. She was managed with oral <em>Ayurvedic</em> medicines: <em>Abha Guggulu, Punarnavashtak Kwatha, Mukta Pishti, Brahma Rasayana</em>; along with <em>Matra Basti</em> of <em>Bala-Ashwagandha Taila</em> and physiotherapy. After 9 months of systemic treatment and physiotherapy, complete healing was achieved as assessed by Magnetic Resonance Imaging (MRI) and Western Ontario Meniscal Evaluation Tool (WOMET). Standalone Ayurvedic management resulted in positive outcomes. The objective is to unveil the inherent healing potential of <em>Ayurveda</em> that may serve as a lead for further research and a hope for those who defer from surgery due to various constraints.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 4","pages":"Article 101374"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148562139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of coronary artery disease related single nucleotide-polymorphisms with extreme Prakriti types: Insights from a case control study 冠状动脉疾病相关单核苷酸多态性与极端Prakriti类型的关联:来自病例对照研究的见解
IF 2.1
Journal of Ayurveda and Integrative Medicine Pub Date : 2026-07-01 Epub Date: 2026-07-08 DOI: 10.1016/j.jaim.2026.101371
Pamila Dua, Deep Shikha Punera, Dhwani Dholakia, Archana Vats, Shivam Pandey, Sandeep Seth, Mitali Mukerji, Subir Kumar Maulik, Bhavana Prasher, K.H. Reeta
{"title":"Association of coronary artery disease related single nucleotide-polymorphisms with extreme Prakriti types: Insights from a case control study","authors":"Pamila Dua,&nbsp;Deep Shikha Punera,&nbsp;Dhwani Dholakia,&nbsp;Archana Vats,&nbsp;Shivam Pandey,&nbsp;Sandeep Seth,&nbsp;Mitali Mukerji,&nbsp;Subir Kumar Maulik,&nbsp;Bhavana Prasher,&nbsp;K.H. Reeta","doi":"10.1016/j.jaim.2026.101371","DOIUrl":"10.1016/j.jaim.2026.101371","url":null,"abstract":"<div><h3>Background</h3><div>Coronary artery disease has well-established genetic variants but identification of susceptible ones is needed. Ayurveda stratifies people phenotypically termed as “<em>Prakriti”</em> to assess the risk.</div></div><div><h3>Objectives</h3><div>The present research was aimed to identify <em>Prakriti</em> stratified genetic risks for CAD.</div></div><div><h3>Material and methods</h3><div>Initially, literature search was done using bioinformatics and manual-curation, to identify susceptible SNPs. Further, global-screening-array was performed to evaluate association of these polymorphisms in <em>Prakriti</em> stratified 200 CAD patients and 100 healthy controls. Thereafter, association of these polymorphisms with already done biochemical parameters and biomarkers was explored.</div></div><div><h3>Results</h3><div>Bioinformatic approach resulted in 466 PMIDs reporting 694 SNPs associated with CAD. Further, manual search for only susceptible resulted in 255 susceptible SNPs across 134 candidate genes with 2.09 cumulative odds ratio in diverse populations. Among 255 SNPs, GSA analysis of isolated DNA samples of present cohort identified 5 SNPs (rs1544410, rs731236, rs1801133, rs7975232, and rs3825807) in VDR, MTHFR, ADAMTS7 genes in overall comparisons. While <em>Prakriti</em> stratification showed association of 4 SNPs in <em>Vata</em>, 8 SNPs in <em>Pitta</em> and 1 SNP in <em>Kapha Prakriti</em> group which were comparable with already documented biochemical parameters and biomarkers. Overall, stratification helped in assessing disease predisposition in specific <em>Prakriti</em> like <em>Vata</em> may be predisposed due to inflammatory pathways<em>, Pitta</em> due to Vitamin D deficiency and <em>Kapha</em> due to disturbed glycemic index.</div></div><div><h3>Conclusion</h3><div>Overall, we could identify 255 SNPs as risk factors for CAD in diverse populations and 5 SNPs in Indian cohort. Further, integrating <em>Prakriti</em> stratification could help in identifying more précised risks for personalized CAD management.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 4","pages":"Article 101371"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148411550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute ocular toxicity study of Chandrodaya Varti Anjana in albino rabbits: A safety assessment 白化病家兔急性眼毒性研究:安全性评价。
IF 2.1
Journal of Ayurveda and Integrative Medicine Pub Date : 2026-07-01 Epub Date: 2026-07-08 DOI: 10.1016/j.jaim.2026.101363
Sangita Shekhaliya, Narayan Bavalatti, Manjusha Rajagopala
{"title":"Acute ocular toxicity study of Chandrodaya Varti Anjana in albino rabbits: A safety assessment","authors":"Sangita Shekhaliya,&nbsp;Narayan Bavalatti,&nbsp;Manjusha Rajagopala","doi":"10.1016/j.jaim.2026.101363","DOIUrl":"10.1016/j.jaim.2026.101363","url":null,"abstract":"<div><div>Cataract is a clouding of the lens, that normally affects vision. It is the leading cause of reversible blindness and visual impairment globally. <em>Chandrodaya Varti Anjana</em>, a classical Ayurvedic herbo mineral formulation, is widely used in ophthalmic practice for conditions such as <em>Timira</em> (∼blurred vision), <em>Arma</em> (∼pterygium) and <em>Kacha</em> (∼opacity of lens). Despite its clinical acceptance, toxicological evaluation of its ocular safety is limited. Aim of the study is to evaluate the acute ocular toxicity of <em>Chandrodaya Varti Anjana</em> in albino rabbits. Albino rabbits were included for the study after approval of IAEC. As per the OECD guidelines 0.1 g of testing drug was placed in the conjunctival sac of one eye each animal. The lids were then gently held together for 2 s. Throughout the 21-days study period, none of the test animals exhibited conjunctival corneal, or iridial reactions and no signs of chemosis were observed. Acute ocular toxicity study indicates that topical application of <em>Chandrodaya Varti Anjana</em> was well-tolerated in albino rabbits without any signs of ocular toxicity. These findings provide a preliminary safety profile that supports the potential for future clinical evaluation in humans. However, further studies with larger animal samples and controlled human clinical trials are necessary to establish definitive safety and efficacy.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 4","pages":"Article 101363"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148411605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antidiabetic potential of a novel hydroxyphenyl-bi-benzopyran-hexol compound from Cassia fistula as an α-amylase inhibitor: Integrated in silico screening and in vitro validation using a nonlinear regression model 从决明子中提取的新型羟基苯基-双苯并吡喃-己醇化合物作为α-淀粉酶抑制剂的降糖潜力:集成硅筛选和使用非线性回归模型的体外验证。
IF 2.1
Journal of Ayurveda and Integrative Medicine Pub Date : 2026-07-01 Epub Date: 2026-07-24 DOI: 10.1016/j.jaim.2026.101366
Rajamanickam Baskar, Manoharan Harini, Sikkal Selvaraaju Selvapriya, Thangarasu Hemadevi, Arumugam Rajalakshmi, Kuppuswamy Kavitha, Rengarajulu Puvanakrishnan, Balasubramanian Ramesh
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