Journal of Ayurveda and Integrative Medicine最新文献

{"title":"Standardization of the traditional Pudam process in the manufacturing of Siddha medicine Anna Pavala Chendooram by using an innovative electrical device","authors":"A.S. Ganesh Kumar ,&nbsp;Senthilvelan Selvaraj ,&nbsp;V.M. Ravichandran ,&nbsp;P Selva Shunmugam ,&nbsp;V. Kamalanathan","doi":"10.1016/j.jaim.2025.101156","DOIUrl":"10.1016/j.jaim.2025.101156","url":null,"abstract":"<div><div><strong>Background:</strong> The Siddha medicine system is one of the oldest traditional medicine systems and requires engineering equipment to reduce skill dependency for medicine manufacturing without compromising the efficacy of the medicine. <strong>Objective:</strong> The objective of the current work was to study the standard manufacturing method for a Siddha medicine <em>anna pavala chendooram</em> as per the conventional method and manufacture it in an electrical device designed for <em>pudam</em> process characterize it. <strong>Material and methods:</strong> <em>Annabedhi</em> (Ferrous sulfate) and <em>kodipavalam</em> (Coral) were taken as raw materials, <em>anna pavala chendooram</em> was prepared in the pit per conventional methods, and the same medicine was prepared in an electrical device for <em>pudam</em>; the prepared medicine from the pit and the device were characterized using modern scientific methods. <strong>Results:</strong> The maximum pressure built inside the sealed <em>agal</em> during the <em>pudam</em> was 35 mbar, and the maximum temperature during the <em>pudam</em> captured was 635 °C at the bottom. The XRD analysis reveals that the raw material consists of Fe₂O₃ (H₂O)₄, 2Fe (OH) SO₄, and CaSO₄ (H₂O)_4, and the finished medicine consists of Fe₂O₃ and CaSO₄. The XRF analysis reveals that the major oxides in finished medicines were Fe₂O₃(T), SO₃, CaO, and MgO. The average particle size of finished medicine from the pit is 6.52 μm, and the finished medicine from the device with <em>seelaimann</em> is 6.45 μm, and from the device without <em>seelaimann</em> is 6.28 μm. <strong>Conclusion:</strong> The <em>pudam</em> process for making <em>anna pavala chendooram</em> can be done using the device for <em>pudam</em> with the temperature profile obtained from the pit.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 4","pages":"Article 101156"},"PeriodicalIF":1.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144489609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Withania somnifera derived natural products as promising inhibitors of Mycobacterium tuberculosis Pantothenate Kinase-PanK: An integrated in silico and in vitro approach","authors":"Ankita Singh ,&nbsp;Usha Mina ,&nbsp;Pardeep Yadav","doi":"10.1016/j.jaim.2025.101158","DOIUrl":"10.1016/j.jaim.2025.101158","url":null,"abstract":"<div><h3>Background</h3><div>Tuberculosis remains a pervasive and enduring global health challenge, with the alarming rise of drug-resistant variants. <em>Mycobacterium tuberculosis</em> (<em>M. tuberculosis</em>), bacterium responsible for tuberculosis, deploys a complex arsenal of virulence factors to evade the host’s immune defences. The quest for novel targets or compounds to combat drug-resistant <em>M. tuberculosis strains</em> is of paramount importance. PanK is an essential enzyme for Co-enzyme A (CoA) biosynthesis pathway, targeting inhibition of its activity by <em>Withania somnifera</em> phytochemicals may provide an effective therapeutic strategy against resistant strains.</div></div><div><h3>Objective</h3><div>The study aims to identify the potential of natural compounds derived from <em>Withania somnifera</em> as inhibitors of the PanK enzyme (novel target) in <em>M. tuberculosis</em>.</div></div><div><h3>Methodology</h3><div><em>In silico</em> computational approach, includes steps-structure based virtual screening of 83 Withania compounds followed by molecular docking and dynamic simulations spanning 100 ns, to assess the binding affinity and stability between screen key compounds and PanK. <em>In vitro</em> anti-tuberculosis bioassays was also performed to validate the <em>In silico</em> experiments finding.</div></div><div><h3>Result</h3><div>Through <em>in silico</em> experiments, four key compounds of <em>Withania somnifera were</em> —Morkotin A, Rutin, Withaoxylactone, and 2,3-Dihydrowithanolide E were identified. They exhibited strong potential to inhibit PanK enzyme activity. The <em>In silico</em> as well as <em>In vitro</em> findings suggest that <em>Withania somnifera</em>-derived natural compounds could serve as effective candidates for targeting vital enzymes in <em>M. tuberculosis</em>.</div></div><div><h3>Conclusion</h3><div><em>Withania somnifera</em> can be explored as valuable resource for developing novel drugs for PanK as a target to combat tuberculosis.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 4","pages":"Article 101158"},"PeriodicalIF":1.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144489608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network pharmacology and in-silico studies for molecular mechanisms of analgesic, anti-inflammatory and anti-arthritic effects of Withania somnifera (L.) Dunal phytoconstituents","authors":"Mukul S. Tambe ,&nbsp;Shreyas R. Shinde ,&nbsp;Akshay M. Baheti ,&nbsp;Shuchi Nagar ,&nbsp;Anil T. Pawar","doi":"10.1016/j.jaim.2024.101088","DOIUrl":"10.1016/j.jaim.2024.101088","url":null,"abstract":"<div><h3>Background</h3><div><em>Withania somnifera</em> (L.) Dunal, commonly known as ashwagandha, is an Ayurvedic herb belonging to the family Solanaceae.</div></div><div><h3>Objectives</h3><div>This study aims to explore the analgesic, anti-inflammatory and anti-arthritic potential of phytoconstituents of <em>Withania somnifera</em> (L.) Dunal (<em>W. somnifera</em>) by network pharmacology and <em>in-silico</em> docking studies.</div></div><div><h3>Methods</h3><div>Five major phytoconstituents, namely ashwagandhanolide, quercetin, withaferin A, withanone and withanolide A, were selected for the network pharmacology study. All five phytoconstituents were further evaluated for their binding properties using molecular docking (MD) and simulation tools. The compounds that exhibited significant binding affinities were further studied for pharmacokinetic and toxicity (ADMET) predictions.</div></div><div><h3>Results</h3><div>The network pharmacology study showed that out of the five selected constituents, withaferin A, withanolide A and quercetin can interact with various inflammation and pain-related genes. In <em>in-silico</em> studies, all five constituents were found to have significant interactions with inflammatory and nociception proteins cyclooxygenases, lipoxygenase, myeloperoxidase and cathepsin B. Further, ADMET studies predicted that all five phytoconstituents could not cross the blood-brain barrier but have high gastrointestinal absorption and bioavailability. Quercetin was predicted to have mutagenic potential and the other three constituents (withaferin A, withanone and withanolide A) were predicted to have immunotoxicity. The MD simulation studies showed that the complexes lipoxygenase_ashwagandhanolide and cathepsin B_ashwagandhanolide exhibit lower RMSD, RMSF, and higher H-bonding, indicating greater stability of ashwagandhanolide with lipoxygenase and cathepsin B.</div></div><div><h3>Conclusion</h3><div>Ashwagandhanolide, quercetin, withaferin A, withanone, and withanolide A from <em>W. somnifera</em> may show the potential for analgesic, anti-inflammatory, and anti-arthritic activities. These findings provide a foundation for future <em>in</em>-<em>vitro</em> and <em>in</em>-<em>vivo</em> studies to confirm the therapeutic efficacy of these phytoconstituents from <em>W. somnifera</em>.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 4","pages":"Article 101088"},"PeriodicalIF":1.7,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144490656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Epidermolysis Bullosa through Ayurveda- a case report of two siblings","authors":"Kuldeep Kavathiya ,&nbsp;Jitesh Verma ,&nbsp;Umakant Tiwari ,&nbsp;Bharat Bhoyar ,&nbsp;Anamika","doi":"10.1016/j.jaim.2025.101149","DOIUrl":"10.1016/j.jaim.2025.101149","url":null,"abstract":"<div><div>Epidermolysis bullosa (EB) is a group of inherited rare skin disorders that causes the skin to become fragile and blister easily due to minor trauma or friction. Blisters can appear anywhere on the body. There are limitations in treating this disease in the conventional system of medicine. This paper elaborates on the case of two siblings who presented with blisters all over the body with itching, discharge, difficulty in walking, and disfigurement of fingers, toes, and feet. Based on Ayurvedic clinical assessment, the condition was diagnosed as <em>Kapha-pitta</em> dominant <em>Tridoshaja Visphota</em>. They were treated through Ayurveda on the line of <em>Visphota</em> (a type of <em>Kushtha</em>/skin disorder) with the use of <em>Dipana</em> (digestion and metabolism-enhancing), <em>Pachana</em> (enhancing digestion), and <em>Mridu Shodhana</em> (mild bio-cleansing) medicines. Both patients have shown improvement with a reduction in EBDASI (Epidermolysis bullosa disease activity and scaring index) from 174 to 45 and 176 to 39, respectively, in the first and second sibling with 4 months of ayurvedic medication. No relapse was seen in both patients during the next one year. The case study is unique as EB is a genetic disorder with limitations in its management in the conventional system of medicine. Moreover, the authors could not find any published case of EB managed through Ayurveda treatment. Thus, it opens new areas of research in the management of EB through traditional systems of medicine like Ayurveda.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 4","pages":"Article 101149"},"PeriodicalIF":1.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144472100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 14 years overall survival of a patient with stage IV carcinoma of cervix with lung metastasis - A case report of Ayurveda based integrative approach","authors":"Sadanand Prabhakar Sardeshmukh,&nbsp;Vineeta Vasant Deshmukh,&nbsp;Arvind Vishnu Kulkarni,&nbsp;Shweta Rakesh Gujar,&nbsp;Nilambari Sushrut Sardeshmukh,&nbsp;Bhagyashree Sukumar Sardeshmukh,&nbsp;Vinita Sanjog Awalkanthe,&nbsp;Suchita Kishor Shiraskar,&nbsp;Dhananjay Ravindra Deshpande,&nbsp;Sandeep Bhagwan Chavan,&nbsp;Vidya Shrikant Gupta","doi":"10.1016/j.jaim.2024.100990","DOIUrl":"10.1016/j.jaim.2024.100990","url":null,"abstract":"<div><h3>Background</h3><div>Carcinoma of the cervix is a leading cause of cancer-related mortality in women. The commonest metastatic site in cervical cancers is lung. Prognosis of cervical cancer with lung metastasis is very poor.</div></div><div><h3>Case presentation</h3><div>The present patient, an inhabitant of rural India, was diagnosed with squamous cell carcinoma of cervix in stage III, grade II in July 2011. She underwent radical course of pelvic radiotherapy along with concurrent weekly chemotherapy, also received two sittings of brachytherapy after completing external beam radiotherapy. Before initiating radical radiotherapy in 2011, she received a combination of personalised/tailored herbo-mineral Ayurvedic medicines for 1 year and 10 months with an aim to minimise the side effects of radiotherapy. After completing radiotherapy, she was treated with a set of Ayurvedic medicines mainly to boost her immunity and to prevent recurrence. She was asymptomatic with good quality of life; all her radiological and biochemical parameters were within normal range till 2016. During her routine periodic investigations in March 2016, X-ray chest revealed nodular opacity on peripheral aspect of left mid zone. Patient underwent CT guided left lung mass biopsy which confirmed the diagnosis as squamous cell carcinoma of left lung (non-small cell type). At this point, the primary cancer was metastasized to lung and upgraded from stage III to stage IV. For this, she was treated with palliative course of radiotherapy. She has been taking regularly oral Ayurvedic medicines till date.</div></div><div><h3>Conclusion</h3><div>Progression free survival of six years and overall survival of 14 years along with exceptional good quality of life has been observed in Stage IV cervical cancer patient with lung metastasis. This has been achieved by integrative approach of conventional cancer treatment of radiotherapy and personalised adjunct Ayurvedic treatment containing combination of oral herbo-mineral metallic medicines.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 4","pages":"Article 100990"},"PeriodicalIF":1.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceptions, knowledge, attitude, practices and barriers towards research among Ayurveda interns: A cross - sectional pilot study","authors":"Arati Darvajkar ,&nbsp;Urmila Shirke ,&nbsp;Amruta Kakade ,&nbsp;Asmita Wele ,&nbsp;Jijaba Shirke","doi":"10.1016/j.jaim.2025.101150","DOIUrl":"10.1016/j.jaim.2025.101150","url":null,"abstract":"<div><h3>Background</h3><div>Research in Ayurveda takes the form of discovery of many scientific principles that guide innovations and evidence based clinical practice. It has been essential part of basic Ayurvedic education for over a decade, which provides ground for evaluation.</div></div><div><h3>Objective</h3><div>This study aims to evaluate the perceptions, knowledge, attitude, practices and barriers towards research among Ayurveda interns, and to identify factors that may influence them.</div></div><div><h3>Methods</h3><div>A cross sectional study was carried out between the period of September 30, 2023 and October 30, 2023 amongst Ayurveda interns from all over India. Data was collected using a validated questionnaire and disseminated via google forms. The questionnaire was based on Perception, Knowledge, Attitude, Practice and Barriers towards research domains. A total of 28 questions were included in the questionnaire. 21 questions were assessed using Likert scale, 3 questions with 1–10 Rating Scale and 4 questions were yes and no type.</div></div><div><h3>Results</h3><div>A total of 199 participants from 31 different colleges and from 9 states responded to the survey<strong>.</strong> The mean age of study participants was 23.73 (SD = 1.854). Most of the students had a positive approach and willingness to participate in medical research, but the most challenging factor in maintaining their interest was mentoring and guidance. This survey highlights a few barriers like time constraints, insufficient motivation, mentorship gaps and limited awareness of sources of funding for research among Ayurveda graduates. Appropriate measures to overcome these barrier might be very useful in changing the perception, willingness and attitude of the students.</div></div><div><h3>Conclusion</h3><div>Fresh graduates in Ayurveda are open to meaningful research if they can find competent mentors and guidance.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 4","pages":"Article 101150"},"PeriodicalIF":1.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacoinformatics in identifying therapeutically important chemical species from Ayurvedic formulations employed in treating COVID-19 patients","authors":"Akash G. Kendre ,&nbsp;Akash Dey ,&nbsp;Ramadas Maganti ,&nbsp;Sumit Srivastava ,&nbsp;Sanjay M. Jachak ,&nbsp;Prasad V. Bharatam","doi":"10.1016/j.jaim.2025.101161","DOIUrl":"10.1016/j.jaim.2025.101161","url":null,"abstract":"<div><h3>Background</h3><div>Ayurveda provided many innovative solutions during the COVID-19 pandemic. It is important to explore the phytochemical constituents in effective Ayurvedic formulations.</div></div><div><h3>Objective</h3><div>The main aim of the work is to identify active phytoconstituents from five Ayurvedic formulations employed in treating COVID-19 patients in an Ayurvedic hospital.</div></div><div><h3>Material and methods</h3><div>Pharmacoinformatics technologies were employed in this study. The chemoinformatics, 3D molecular structure building, and molecular docking of 967 compounds on eight different macromolecular viral targets associated with SARS-CoV-2 were carried out using GLIDE software. Molecular dynamics simulations were also performed. SwissADME web server was employed to determine the physicochemical, lipophilicity and absorption, distribution, metabolism, and excretion (ADME) parameters.</div></div><div><h3>Results</h3><div>The molecular docking results indicate that quercetin-3-O-arabinoglucoside, quercetin-3,7-O-diglucoside, glycyrrhizin, calceolarioside B, mucic acid-2-gallate, protodioscin and indioside D are the phytochemicals which effectively bind to eight of the proteins of SARS-CoV-2 virus and these may be treated as new lead compounds for multi-target drug discovery for SARS-CoV-2 inhibition. MD simulations helped in identifying five leads out of seven chosen from docking analysis.</div></div><div><h3>Conclusion</h3><div>Five Ayurvedic formulations were used to treat respiratory illnesses associated with COVID-19. Five phytoconstituents present in these formulations were identified as leads by employing pharmacoinformatics techniques.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 4","pages":"Article 101161"},"PeriodicalIF":1.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of pharmacological potentialities of Bauhinia acuminata L. fruits by in vitro and in vivo assays supported by computational analysis","authors":"Protyasha Sikdar ,&nbsp;Pritam Kundu ,&nbsp;Fatema-Tuz- Zohora ,&nbsp;Mst. Rehena Aktar ,&nbsp;Bani Brota Biswas ,&nbsp;Md. Sadman Hossain ,&nbsp;Muaz Faruque ,&nbsp;Khondoker Shahin Ahmed ,&nbsp;Hemayet Hossain ,&nbsp;Kishor Mazumder ,&nbsp;Nripendra Nath Biswas ,&nbsp;Samir Kumar Sadhu","doi":"10.1016/j.jaim.2025.101127","DOIUrl":"10.1016/j.jaim.2025.101127","url":null,"abstract":"<div><h3>Background</h3><div>In Ayurveda, <em>Bauhinia acuminata</em> L. had been used to treat diabetes, skin diseases, and swelling.</div></div><div><h3>Objective</h3><div>The study was designed to assess the antidiabetic, anti-inflammatory, and antibacterial potentialities of <em>B. acuminata</em> fruits ethanolic extract. Phytochemical characterization by HPLC analysis, pure compound isolation by column chromatography and <em>in silico</em> analysis were performed.</div></div><div><h3>Methods</h3><div>Column chromatography was conducted to isolate pure compounds. HPLC analysis was performed using sixteen standard polyphenol s. Three different methods evaluated the antidiabetic effect of the extract. Analgesic property was evaluated. Protein denaturation and formalin-induction tests were done to measure the anti-inflammatory effect. Brewer's yeast-induced pyrexia was followed to assess the antipyretic effect. Antibacterial tests were performed using disc diffusion and anti-biofilm activity assay. Binding interaction was investigated by molecular docking (MD) analysis. Moreover, oral bioavailability and toxicity profiles were analyzed using ADMET assay.</div></div><div><h3>Results</h3><div>We have isolated <em>β</em>-sitosterol and <em>β</em>-sitosterol-3-<em>O</em>-<em>β</em>-D-glucoside from the extract. Presence of four polyphenols was evident by HPLC analysis. The extract and two isolated compounds showed prominent <em>α</em>-glucosidase inhibition. No mortality and abnormality were found in the acute toxicity test. The extract exhibited good peripheral analgesic and anti-inflammatory properties in a dose-dependent fashion and antipyretic effect. The extract inhibited biofilm formation on the test bacterial colony. MD analysis revealed better binding characteristics of two identified phytosterols, rutin hydrate, and kaempferol with selected protein molecules. ADMET analysis exerted compliance with the compounds except rutin with Lipinski’s rule of five.</div></div><div><h3>Conclusion</h3><div>The assessment revealed that <em>B. acuminata</em> fruits extract can elicit good antidiabetic, anti-inflammatory, and antibacterial responses.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 4","pages":"Article 101127"},"PeriodicalIF":1.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144329943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eighteen months of non-union of an upper third tibial fracture treated with Ayurvedic herbal medicines and Panchakarma: A case report","authors":"Sadanand P. Sardeshmukh ,&nbsp;Sharad Hardikar ,&nbsp;S. Prakash ,&nbsp;Ranjit G. Nimbalkar ,&nbsp;Anil T. Pawar ,&nbsp;Akshay M. Baheti ,&nbsp;Manasi R. Nimbalkar","doi":"10.1016/j.jaim.2024.101105","DOIUrl":"10.1016/j.jaim.2024.101105","url":null,"abstract":"<div><div>In the present case, a 29-year-old male met with a road traffic accident and sustained a closed comminuted fracture of the upper third (U/3) of the tibia of his left leg. The patient was operated (Open Reduction Internal Fixation, ORIF) with internal nailing. Even after 18 months, the fracture line was visible in the X-ray, so he was re-operated (ORIF) and the nail was replaced by plate fixation. However, after the second operation, the patient developed foot drop and hyperesthesia due to peroneal nerve injury. In view of this complicated history, the patient was suggested to take supportive Ayurvedic medicines and <em>Panchakarma</em> to hasten the healing process. The Ayurvedic medicines <em>Lakshadi guggul</em> 500 mg, <em>Mashadi Yoga</em> 500 mg and <em>Asthi majja yoga</em> 500 mg three times a day were started. The follow-up X-ray examination after eight months of treatment didn't show considerable callus at the fracture site, so <em>P</em><em>anchakarma</em> therapy was given for 21 days. Callus formation was seen within 3 weeks after completing <em>P</em><em>anchakarma</em> treatment. The oral medications were continued and a follow-up X-ray examination on two more months of treatment showed near complete healing (Fracture line was obliterated because of considerable callus). The medicine was continued for two more months. Afterwards, the patient came back after one year and the follow-up X-ray examination showed complete healing. The internal plate was removed and complete fracture recovery was reported. Thus, a patient with a non-union fracture of the tibia was treated successfully with add-on Ayurvedic medicines and <em>P</em><em>anchakarma</em> therapy.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 3","pages":"Article 101105"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144114828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Lekhan Basti and Navak Guggul on lipid markers and transcriptional effects of selected genes in obese patients: A single-centre, open-labelled, randomized, comparative, pilot study","authors":"Renuka Munshi,&nbsp;Falguni Panchal,&nbsp;Dipti Kumbhar","doi":"10.1016/j.jaim.2025.101129","DOIUrl":"10.1016/j.jaim.2025.101129","url":null,"abstract":"<div><h3>Background</h3><div>Ayurveda recommends an integrative approach of <em>shodhana</em> &amp; <em>shamana</em> therapy for Obesity management.</div></div><div><h3>Objective</h3><div>This study evaluated the safety and efficacy of <em>Navak Guggul</em> and <em>Lekhan Basti,</em> individually and in combination, with respect to anthropometric, biochemical levels and transcriptional profiling of selected candidate genes in obese participants.</div></div><div><h3>Material and methods</h3><div>Single-centre, open-labelled, randomized, comparative, pilot study was conducted following Institutional Ethics Committee approval. 64 obese participants of either gender, aged between 25 and 60 years with BMI 28–32.9 kg/m² and WHR (Men&gt;0.90 and Women&gt;0.85) were randomly allocated to four groups, each with 16 participants, to receive either <em>Navak Guggul</em> or <em>Lekhan Basti,</em> individually or in combination or no treatment in addition to diet and lifestyle modification. Anthropometric measurements, ayurvedic symptoms severity score, impact of weight on quality of life (IWQOL), biochemical tests and genetic expressions of select genes (UCP2, AD1POR1, FTO, GHRL, Leptin and PPARγ) were assessed at baseline (V1), immediately after therapy (V4) and 2 months post-therapy (V6).</div></div><div><h3>Results</h3><div>50 participants completed the study. Participants from all groups showed significant reduction in BMI (except Group IV) with significant improvement in the ayurvedic symptoms score. Improvement in the IWQOL score was seen at V4 in all groups with maximal reduction in serum lipids in Groups I and III. Transcriptional profiling revealed increased expression of UCP2, ADIPOR1 and PPARγ genes at V4 and decreased expression of FTO, Ghrelin and Leptin genes compared to V1.</div></div><div><h3>Conclusion</h3><div><em>Lekhan Basti</em> and combination therapy were beneficial in reducing anthropometric and lipid parameters. Several genes were differentially expressed immediately post-treatment suggesting their role as candidate genes in obesity management.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 3","pages":"Article 101129"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}