Journal of Ayurveda and Integrative Medicine最新文献

{"title":"'Ayurvedagranthasamuccaya' (APTA Digital Library) - A searchable digital bouquet of classical Ayurveda books","authors":"V. Rakesh Narayanan , Madan Mohan Sharma , Saketh Ram Thrigulla , Vinod Kumar Lavaniya , Mukesh Bhagwan Chincholikar , V. Ashwathykutty , Adarsh Kumar , Pratap Makhija , Narayanam Srikanth","doi":"10.1016/j.jaim.2024.101093","DOIUrl":"10.1016/j.jaim.2024.101093","url":null,"abstract":"","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 3","pages":"Article 101093"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143929493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal Ayurvedic intervention provided 15 years of progression free survival to a female patient with recurrent squamous cell carcinoma of tongue - A case report","authors":"Sadanand Sardeshmukh,&nbsp;Vineeta Deshmukh,&nbsp;Vasanti Godse,&nbsp;Shrinivas Datar,&nbsp;Swapna Kulkarni,&nbsp;Sneha Dalvi,&nbsp;Sushama Bhuvad,&nbsp;Shweta Gujar,&nbsp;Sandeep Chavan","doi":"10.1016/j.jaim.2024.100984","DOIUrl":"10.1016/j.jaim.2024.100984","url":null,"abstract":"<div><div>Oral Squamous Cell Carcinoma (OSCC) is the most common type of oral cancer, accounting for 90%–95% of all cancers in the mouth. It is typically noted in individuals over the age of 40, especially men between 60 and 80. However, there has been a recent increase in oral cancer cases among women and younger individuals. We present a case of a 49-year-old female diagnosed with Stage III, moderately differentiated Squamous cell carcinoma of the tongue in August 2005. The patient underwent radiation therapy (35 fractions/70 Gy) and received adjunct chemotherapy (6 cycles of Inj. Cisplatin – LD on October 21, 2005). Despite these treatments, residual induration on the tongue persisted, leading to a Knife biopsy in April 2007 that confirmed the presence of squamous carcinoma infiltrating the lingual muscles. Further, she underwent Wide Excision Glossectomy with Left Supra-Omohyoid Neck Dissection in May 2007 and Total Glossectomy with Hemi mandibulectomy with Left Supra-Omohyoid Neck Dissection in August 2011. In addition to conventional cancer treatments, the patient opted for Ayurvedic treatment at our center, which included a combination of oral Herbo-mineral metallic medicines and detoxifying <em>Panchakarma</em> procedures. The 12-year progression-free survival achieved in this case highlights the potential benefits of combining conventional cancer treatment with personalized adjunct Ayurvedic therapy.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 3","pages":"Article 100984"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144098592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of topical analgesia Zanthoxylum rhetsa in the treatment of primary knee osteoarthritis: A randomized, double-blind, positive-controlled clinical trial","authors":"Chureeporn Imphat ,&nbsp;Nanthakarn Woottisin ,&nbsp;Wiwat Chiewsilp","doi":"10.1016/j.jaim.2024.101108","DOIUrl":"10.1016/j.jaim.2024.101108","url":null,"abstract":"<div><h3>Background</h3><div>The essential oil from the pericarp (EOP) of <em>Zanthoxylum rhetsa</em> (Roxb.) DC. inhibits prostaglandin E₂, which is related to knee osteoarthritis (OA). However, there is no clinical report on its efficacy.</div></div><div><h3>Objectives</h3><div>To assess the efficacy of EOP in <em>Z. rhetsa</em> (ZR) spray as a novel spray compared to diclofenac (DF) spray in elderly individuals diagnosed with primary knee OA.</div></div><div><h3>Methods</h3><div>60 patients with unilateral knee pain over three months were randomly assigned to either the ZR spray (experimental) or DF spray (control) group. Each group applied the spray topically 3 times daily (2 mL each time) for 14 consecutive days. Follow-ups occurred after day 7 and after day 14. Primary outcomes included pain score measurements, with secondary outcomes focusing on WOMAC index scores.</div></div><div><h3>Results</h3><div>The ZR and DF spray groups did not significantly differ at baseline. ZR spray is the first to demonstrate non-inferior efficacy compared to DF spray, with no significant difference in the mean change of pain scores at rest after 10 min (effect size &lt;0.2) and following a 20-m walk test (effect size &lt;0.5), including walking time (effect size &lt;0.2), as well as in WOMAC index scores (effect size &lt;0.3) from baseline to the first and second visits. Additionally, patients treated with ZR spray required less oral medication from the first visit.</div></div><div><h3>Conclusions</h3><div>Analgesia and improved knee functionality provided by ZR spray are suitable for combined treatment in elderly patients with co-morbidities or limited oral NSAID medication due to increased risk.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 3","pages":"Article 101108"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144105999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyherbal formulation mitigates age-associated cognitive deficits in rats","authors":"Manoj P. Dandekar ,&nbsp;Sandeep Guin ,&nbsp;Shivkumar Sammeta ,&nbsp;Chandrima Saha ,&nbsp;Harshada Anil Bhalerao ,&nbsp;Rajesh Sonti","doi":"10.1016/j.jaim.2025.101131","DOIUrl":"10.1016/j.jaim.2025.101131","url":null,"abstract":"<div><h3>Background</h3><div>Age-related cognitive decline is a common biological phenomenon that appears to be driven by accelerated oxidative stress pathways. As natural polyherbal phytoconstituents positively modulate such pathological changes, herbal formulations are gaining notable attention in the mitigation of age-associated cognitive impairments.</div></div><div><h3>Objectives</h3><div>To study the effect of polyherbal extracts on cognitive functions in 52–54 weeks old rats compared to young adult rats.</div></div><div><h3>Material and methods</h3><div>The anxiety as well as learning and memory functions were assessed employing elevated plus maze, Morris water maze (MWM), and novel object recognition test (NORT). The levels of antioxidant enzymes, acetylcholinesterase (AChE), neurotransmitters, cytokines, and brain-derived neurotrophic factor (BDNF) were estimated in blood and/or brain samples using biochemical assays, LC−MS/MS, ELISA, and immunofluorescence methods.</div></div><div><h3>Results</h3><div>The peroral administration of polyherbal plant extracts for 12 weeks showed trends toward improvement of learning and memory functions in the MWM and/or NORT in 52–54 weeks old rats. The locomotor activity and anxiety-like behavior remained similar in young vs. aged rats. We noted lowered levels of antioxidant enzymes (superoxide dismutase, catalase, reduced glutathione, glutathione peroxidase, and homocysteine) and AChE in the frontal cortex of brain and/or blood samples of 52–54 weeks old rats. We also observed the negative impact of aging on the levels of neurotransmitters (dopamine, noradrenaline, and 5-HT), cytokines (TNF-α, IL-6, and CRP), BDNF, and NeuN expression in the hippocampus/frontal cortex in 52–54 weeks old rats vs. young rats. The altered levels of these antioxidant enzymes, AChE, neurotransmitters, cytokines, and other biogenic substances were reversed in polyherbal-recipient rats.</div></div><div><h3>Conclusions</h3><div>Our results indicate that the memory-improving activity of polyherbal formulation may be attributed to antioxidant, anti-inflammatory, and neuroprotective properties. Thus, we suggest the utility of this Indian polyherbal formulation in delaying the onset or reducing age-associated cognitive impairments.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 3","pages":"Article 101131"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of integrated protocol in the management of ankle sprain in sports injuries - A randomized controlled clinical trial","authors":"Dinesh Goud ,&nbsp;Ramesh S. Killedar ,&nbsp;Shindhe Pradeep S ,&nbsp;Deepti Bagewadi","doi":"10.1016/j.jaim.2025.101132","DOIUrl":"10.1016/j.jaim.2025.101132","url":null,"abstract":"<div><h3>Background</h3><div>Among athletes, ankle sprains are the most frequent injury, with an prevalence of 12.62% of all injuries. Sports injuries can be prevented and treated more effectively when complementary and alternative medicine is used. In <em>Ayurveda</em> ankle joint injuries are correlated with <em>Gulpha</em> (ankle) <em>marmabhighata</em> (injury to important point of concern for health) and management is done accordingly. Integrated approach using <em>Ayurveda</em> and Physiotherapy protocol is the need of hour to produce evidence-based results.</div></div><div><h3>Objectives</h3><div>To evaluate the efficacy of the integrated management protocol of ankle sprain in sports injuries.</div></div><div><h3>Materials and methods</h3><div>A total of 30 patients with ankle sprains were recruited after satisfying the inclusion and exclusion criteria. The procedures (Integrated and Standard) were performed after obtaining informed consent, and the participants were divided into two groups, i.e., the treatment group (integrated approach) and the control group (standard approach). Parameters like pain, swelling, temperature, tenderness, range of motion and manual muscle testing were all measured at baseline and at various time points (6^th, 11^th, and 18^th day) throughout the study.</div></div><div><h3><em>Statistical analysis</em></h3><div>The data was analysed with the Mann-Whitney <em>U</em> test, Wilcoxon matched pairs test, independent 't’ test, and dependent ‘t'test.</div></div><div><h3>Results</h3><div>The treatment group has shown significantly better results (within and between groups) than the control group in relation to all the parameters like pain, tenderness, temperature, swelling, range of motion, and manual muscle testing.</div></div><div><h3>Conclusion</h3><div>An integrated approach using <em>Ayurveda</em> and physiotherapy was found to be more effective than the standard approach in the management of ankle sprains.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 3","pages":"Article 101132"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144190089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aqueous leaf extract of Vitex negundo modulates M1-M2 phenotypic switch and functional changes in human macrophages in an in vitro model of hypertension","authors":"Boniface Makori Nyamweya ,&nbsp;Dilani Rukshala ,&nbsp;Rajiva De Silva ,&nbsp;Sunil Premawansa ,&nbsp;Narmada Fernando ,&nbsp;Shiroma Handunnetti","doi":"10.1016/j.jaim.2025.101148","DOIUrl":"10.1016/j.jaim.2025.101148","url":null,"abstract":"<div><h3>Background</h3><div>Inflammation and oxidative stress are key drivers of hypertension. <em>Vitex negundo</em> L. is a medicinal plant used in Ayurveda and has potential anti-inflammatory effects.</div></div><div><h3>Objectives</h3><div>This study aims to assess the immunomodulatory effects of aqueous mature leaf extract (ALE) of <em>V. negundo</em> in an <em>in vitro</em> model of hypertension.</div></div><div><h3>Materials and methods</h3><div>Non-toxic concentrations of ALE were selected using SRB and MTT assays. Quantitative NBT and Griess assays were done to assess the effect of the ALE on Ang-II-induced production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) respectively. The effect of ALE of <em>V. negundo</em> on the expression of tumor necrosis factor-alpha, interleukin 6, interleukin 1 beta and nuclear factor kappa B were assessed using RT-qPCR. Expression of M0, M1 and M2 surface markers were assessed using flow cytometry.</div></div><div><h3>Results</h3><div>ALE of <em>V. negundo</em> inhibited the production ROS and RNS in a dose-dependent manner comparable with Telmisartan drug control (p &lt; 0.0001)<em>.</em> Ang-II activated, THP-1 derived macrophages expressed high levels of M1 markers. Interestingly, the pre-treatment of Ang-II-activated, THP-1 derived macrophages with ALE of <em>V. negundo</em> increased the expression of M2 marker as CD206^high (89.63%) but no increase in CD163-moderate (27.1%). Both ALE of <em>V. negundo</em> and Telmisartan down-regulated the expression of the pro-inflammatory cytokines in the hypertension model (p &lt; 0.0001).</div></div><div><h3>Conclusions</h3><div>The results suggest the potential of ALE of <em>V. negundo</em> in exerting immunomodulatory effects in an <em>in vitro</em> model of angiotensin II-mediated hypertension mainly by modulating M1-M2 macrophage switch and limiting inflammation and production of pro-oxidants.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 3","pages":"Article 101148"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual stimulatory effects of Mucuna pruriens in rodents: An experiment following Ayurvedic perspective","authors":"Muralikrishnan Dhanasekaran ,&nbsp;Binu Tharakan ,&nbsp;Jeyaram Bharathi Jeyabalan ,&nbsp;Suhrud Pathak ,&nbsp;Keyi Liu ,&nbsp;Rishi Nadar ,&nbsp;Timothy Moore","doi":"10.1016/j.jaim.2025.101130","DOIUrl":"10.1016/j.jaim.2025.101130","url":null,"abstract":"<div><h3>Background</h3><div>Dopaminergic neurotransmission is critical to managing a variety of physiological activities, including sexual behavior. Erectile dysfunction is frequently related to low dopamine levels and hyperglycemia, both of which can be alleviated by <em>Mucuna pruriens</em>, a natural source of levodopa and other bioactive compounds. The existing hypothesis depicts that decreased dopaminergic neurotransmission and hyperglycemia lead to erectile dysfunction. . .</div></div><div><h3>Objectives</h3><div>The primary objective of this study was to establish the hypoglycemic action and sexual stimulatory effects of <em>Mucuna pruriens</em> in rodents. The secondary objective was to evaluate the effect on general rodent behavior, which can validate the safety profile of <em>Mucuna pruriens</em> for clinical use.</div></div><div><h3>Methods</h3><div>Standardized <em>Mucuna pruriens</em> extract was given orally to male rodents for a predetermined amount of time. Blood samples were withdrawn from the male rats to measure the glucose levels at predetermined intervals. During mating trials, sexual activity metrics such as mount frequency and delay, intromission frequency, and ejaculation frequency were recorded. Standard open-field and exploratory behavior tests were used to track general behavior and evaluate any unfavorable or unusual changes.</div></div><div><h3>Results</h3><div><em>Mucuna pruriens</em> significantly decreased blood glucose levels and increased male sexual activity and behaviors in rodents (mount frequency and latency, intromission frequency, and ejaculation frequency).</div></div><div><h3>Conclusion</h3><div>Thus, <em>Mucuna pruriens</em> can be the alternative natural bioactive to prevent and treat sexual dysfunction.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 3","pages":"Article 101130"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Anjana Kriyakalpa in refractive errors: Evaluation through refraction and corneal topography indices - A case series","authors":"Deenadayal Devarajan,&nbsp;Manjusha Rajagopala","doi":"10.1016/j.jaim.2025.101128","DOIUrl":"10.1016/j.jaim.2025.101128","url":null,"abstract":"<div><div>Refractive errors, a significant cause of visual impairment, is becoming increasingly prevalent in India, particularly among school children. This case series describes the effects of <em>Pathyadi Varti Anjana</em>, an Ayurvedic herbo-mineral formulation, in refractive errors associated with distant vision. Three patients with varying degrees of myopia and myopic astigmatism were treated with <em>Pathyadi Varti</em> applied as <em>Anjana,</em> twice daily for a period of three to six weeks. Parameters including Visual Acuity (VA), Objective Refraction (OR), Clinical Refraction (CR), and corneal topography metrics such as Simulated Keratometry (Sim K's), Shape Factor (SF), Corneal Irregularity Measurement (CIM), Toric Keratometric Mean (TKM), Root Mean Square (RMS), and PathFinder II Normalcy (PathFII) were assessed before and after treatment. The results demonstrated improvements in unaided VA, reductions in spherical and cylindrical refractive errors, and enhancements in corneal surface regularity and wavefront aberrations across all cases. These findings suggest that <em>Pathyadi Varti Anjana</em> may offer a promising Ayurvedic approach to the management of refractive errors, supporting its potential role in contemporary ophthalmic practices.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 3","pages":"Article 101128"},"PeriodicalIF":1.7,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143740065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of meditation on sustained attention in nonclinical population: An extensive review","authors":"Abinash Roy,&nbsp;Pailoor Subramanya","doi":"10.1016/j.jaim.2024.101057","DOIUrl":"10.1016/j.jaim.2024.101057","url":null,"abstract":"<div><h3>Background</h3><div>Meditation, encompassing focussed attention (FA) and open monitoring (OM) approaches, is recognised for its potential to enhance cognitive functions. Sustained attention, a critical component of attentional processes, influences cognitive capacity and is linked to meditation benefits. However, a robust and extensive review analysis needs to address the specific relationship between meditation and sustained attention in nonclinical populations.</div></div><div><h3>Methods</h3><div>Following PRISMA guidelines, the authors reviewed English articles published from 2013 to 2023 in Q1 SCOPUS-indexed journals. Inclusion criteria comprised original research studies exploring the impact of meditation on sustained attention in healthy individuals. The modified Jadad Scale assessed methodological quality.</div></div><div><h3>Results</h3><div>12 studies (four RCTs, eight non-RCTs) with 1447 participants were included. Concentrative or FA meditation demonstrated consistent positive effects on sustained attention, including reduced perceived stress and increased focussed attention. OM meditation significantly improved sustained attention, as evidenced by reduced mind wandering and enhanced N2 responses. Meditators consistently outperformed non-meditators in sustained attention tasks, demonstrating faster reactions and lower error rates.</div></div><div><h3>Discussion</h3><div>This review explored the impact of meditation on sustained attention across diverse non-clinical populations through 12 investigations involving 1447 subjects with meditation interventions spanning from 21 days to 3 months. The study revealed that both FA and OM meditation approaches positively impact sustained attention, highlighting their potential role in enhancing cognitive function. Meditators consistently exhibited superior sustained attention abilities, suggesting the cognitive benefits of regular meditation practice. The findings of this study are consistent with prior research, contributing to the growing body of knowledge on the advantageous impacts of meditation on sustained attention. However, caution is needed in generalizing findings due to study limitations. Future research should use standardized methodologies and conduct longer-term follow-ups to better elucidate the effects of meditation interventions on sustained attention across diverse populations.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 2","pages":"Article 101057"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143534889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Bhushan Patwardhan","doi":"10.1016/j.jaim.2025.101134","DOIUrl":"10.1016/j.jaim.2025.101134","url":null,"abstract":"","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 2","pages":"Article 101134"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}